DNMT3L cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNMT3L
Entrez Gene ID	29947
Full Name	DNA methyltransferase 3 like
General protein information	Preferred Names DNA methyltransferase 3 like Names DNA (cytosine-5)-methyltransferase 3-like DNA (cytosine-5-)-methyltransferase 3-like cytosine-5-methyltransferase 3-like protein human cytosine-5-methyltransferase 3-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.3
Summary	CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].
Disorder MIM:	606588

mRNA and Protein(s)

mRNA	Protein	Name
NM_175867.3	NP_787063.1	DNA (cytosine-5)-methyltransferase 3-like isoform 2
NM_013369.4	NP_037501.2	DNA (cytosine-5)-methyltransferase 3-like isoform 1
NM_175867.2	NP_787063.1	DNA (cytosine-5)-methyltransferase 3-like isoform 2
NM_013369.3	NP_037501.2	DNA (cytosine-5)-methyltransferase 3-like isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DNMT3L	XP_525483.2
Bos taurus (cattle)	DNMT3L	XP_002685181.1
Mus musculus (house mouse)	Dnmt3l	NP_001075164.1
Homo sapiens (human)	DNMT3L	NP_037501.2
	DNMT3L	XP_001118368.2
Canis lupus familiaris (dog)	DNMT3L	XP_849972.1
Rattus norvegicus (Norway rat)	Dnmt3l	NP_001003964.1

Gene Ontology
Bibliography

Related articles in PubMed

Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression.
Lu J, Mccarter M, Lian G, Esposito G, Capoccia E, Delli-Bovi LC, Hecht J, Sheen V
Human molecular genetics25(9)1714-27(2016 05)

Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility.
Mostowska A, Szczepa?ska M, Wirstlein P, Skrzypczak J, Jagodzi?ski PP
Molecular medicine reports13(1)1040-6(2016 Jan)

Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.
Guo X, Wang L, Li J, Ding Z, Xiao J, Yin X, He S, Shi P, Dong L, Li G, Tian C, Wang J, Cong Y, Xu Y
Nature517(7536)640-4(2015 Jan)

DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NF?B complex in the (de-)methylation of TRAF1.
Pacaud R, Sery Q, Oliver L, Vallette FM, Tost J, Cartron PF
Biochimie10436-49(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DNMT3L overexpression is associated with Down syndrome.
Title: Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression.

the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility.
Title: Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility.

crystal structures of DNMT3A-DNMT3L (autoinhibitory form) and DNMT3A-DNMT3L-H3 (active form) complexes at 3.82 and 2.90 A resolution, respectively
Title: Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.

DNMT3L can address DNMT3A/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A/B
Title: DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NF?B complex in the (de-)methylation of TRAF1.

DNMT3L rs2070565 (genotype P = 0.007, allele P = 0.0026) confers an increased risk of developing schizophrenia at an early age in individuals with family history.
Title: DNA methyl transferase (DNMT) gene polymorphisms could be a primary event in epigenetic susceptibility to schizophrenia.

The following DNMT3L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNMT3L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06515	NM_013369.4 Latest version!	Homo sapiens DNA methyltransferase 3 like (DNMT3L), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu07418	NM_175867.3 Latest version!	Homo sapiens DNA methyltransferase 3 like (DNMT3L), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu07418	NM_175867.2	Homo sapiens DNA methyltransferase 3 like (DNMT3L), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu06515	NM_013369.3	Homo sapiens DNA methyltransferase 3 like (DNMT3L), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNMT3L ( NM_013369.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037501.2 Homo sapiens DNA methyltransferase 3 like (DNMT3L), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06515
Clone ID Related Accession (Same CDS sequence)	NM_013369.4 , NM_013369.3
Accession Version	NM_013369.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1164bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	DNA (cytosine-5)-methyltransferase 3-like isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF194032.1, BC002560.2 and BQ028660.1. On May 31, 2019 this sequence version replaced NM_013369.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF194032.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA1970526 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCA TCCCAGCCCT GGACCCAGAG GCCGAGCCCA GCATGGACGT GATTTTGGTG 
GGATCCAGTG AGCTCTCAAG CTCCGTTTCA CCCGGGACAG GCAGAGATCT TATTGCATAT 
GAAGTCAAGG CTAACCAGCG AAATATAGAA GACATCTGCA TCTGCTGCGG AAGTCTCCAG 
GTTCACACAC AGCACCCTCT GTTTGAGGGA GGGATCTGCG CCCCATGTAA GGACAAGTTC 
CTGGATGCCC TCTTCCTGTA CGACGATGAC GGGTACCAAT CCTACTGCTC CATCTGCTGC 
TCCGGAGAGA CGCTGCTCAT CTGCGGAAAC CCTGATTGCA CCCGATGCTA CTGCTTCGAG 
TGTGTGGATA GCCTGGTCGG CCCCGGGACC TCGGGGAAGG TGCACGCCAT GAGCAACTGG 
GTGTGCTACC TGTGCCTGCC GTCCTCCCGA AGCGGGCTGC TGCAGCGTCG GAGGAAGTGG 
CGCAGCCAGC TCAAGGCCTT CTACGACCGA GAGTCGGAGA ATCCCCTTGA GATGTTCGAA 
ACCGTGCCTG TGTGGAGGAG ACAGCCAGTC CGGGTGCTGT CCCTTTTTGA AGACATCAAG 
AAAGAGCTGA CGAGTTTGGG CTTTTTGGAA AGTGGTTCTG ACCCGGGACA ACTGAAGCAT 
GTGGTTGATG TCACAGACAC AGTGAGGAAG GATGTGGAGG AGTGGGGACC CTTCGATCTT 
GTGTACGGCG CCACACCTCC CCTGGGCCAC ACCTGTGACC GTCCTCCCAG CTGGTACCTG 
TTCCAGTTCC ACCGGCTCCT GCAGTACGCA CGGCCCAAGC CAGGCAGCCC CAGGCCCTTC 
TTCTGGATGT TCGTGGACAA TCTGGTGCTG AACAAGGAAG ACCTGGACGT CGCATCTCGC 
TTCCTGGAGA TGGAGCCAGT CACCATCCCA GATGTCCACG GCGGATCCTT GCAGAATGCT 
GTCCGCGTGT GGAGCAACAT CCCAGCCATA AGGAGCAGCA GGCACTGGGC TCTGGTTTCG 
GAAGAAGAAT TGTCCCTGCT GGCCCAGAAC AAGCAGAGCT CGAAGCTCGC GGCCAAGTGG 
CCCACCAAGC TGGTGAAGAA CTGCTTTCTC CCCCTAAGAG AATATTTCAA GTATTTTTCA 
ACAGAACTCA CTTCCTCTTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037501.2
CDS	166..1329
Translation	MAAIPALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQVHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFECVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDRESENPLEMFETVPVWRRQPVRVLSLFEDIKKELTSLGFLESGSDPGQLKHVVDVTDTVRKDVEEWGPFDLVYGATPPLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSSRHWALVSEEELSLLAQNKQSSKLAAKWPTKLVKNCFLPLREYFKYFSTELTSSL

Target ORF information:

RefSeq Version	NM_013369.4
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA methyltransferase 3 like (DNMT3L), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013369.4

ORF Insert Sequence:

ATGGCGGCCA TCCCAGCCCT GGACCCAGAG GCCGAGCCCA GCATGGACGT GATTTTGGTG 
GGATCCAGTG AGCTCTCAAG CTCCGTTTCA CCCGGGACAG GCAGAGATCT TATTGCATAT 
GAAGTCAAGG CTAACCAGCG AAATATAGAA GACATCTGCA TCTGCTGCGG AAGTCTCCAG 
GTTCACACAC AGCACCCTCT GTTTGAGGGA GGGATCTGCG CCCCATGTAA GGACAAGTTC 
CTGGATGCCC TCTTCCTGTA CGACGATGAC GGGTACCAAT CCTACTGCTC CATCTGCTGC 
TCCGGAGAGA CGCTGCTCAT CTGCGGAAAC CCTGATTGCA CCCGATGCTA CTGCTTCGAG 
TGTGTGGATA GCCTGGTCGG CCCCGGGACC TCGGGGAAGG TGCACGCCAT GAGCAACTGG 
GTGTGCTACC TGTGCCTGCC GTCCTCCCGA AGCGGGCTGC TGCAGCGTCG GAGGAAGTGG 
CGCAGCCAGC TCAAGGCCTT CTACGACCGA GAGTCGGAGA ATCCCCTTGA GATGTTCGAA 
ACCGTGCCTG TGTGGAGGAG ACAGCCAGTC CGGGTGCTGT CCCTTTTTGA AGACATCAAG 
AAAGAGCTGA CGAGTTTGGG CTTTTTGGAA AGTGGTTCTG ACCCGGGACA ACTGAAGCAT 
GTGGTTGATG TCACAGACAC AGTGAGGAAG GATGTGGAGG AGTGGGGACC CTTCGATCTT 
GTGTACGGCG CCACACCTCC CCTGGGCCAC ACCTGTGACC GTCCTCCCAG CTGGTACCTG 
TTCCAGTTCC ACCGGCTCCT GCAGTACGCA CGGCCCAAGC CAGGCAGCCC CAGGCCCTTC 
TTCTGGATGT TCGTGGACAA TCTGGTGCTG AACAAGGAAG ACCTGGACGT CGCATCTCGC 
TTCCTGGAGA TGGAGCCAGT CACCATCCCA GATGTCCACG GCGGATCCTT GCAGAATGCT 
GTCCGCGTGT GGAGCAACAT CCCAGCCATA AGGAGCAGCA GGCACTGGGC TCTGGTTTCG 
GAAGAAGAAT TGTCCCTGCT GGCCCAGAAC AAGCAGAGCT CGAAGCTCGC GGCCAAGTGG 
CCCACCAAGC TGGTGAAGAA CTGCTTTCTC CCCCTAAGAG AATATTTCAA GTATTTTTCA 
ACAGAACTCA CTTCCTCTTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNMT3L ( NM_175867.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_787063.1 Homo sapiens DNA methyltransferase 3 like (DNMT3L), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07418
Clone ID Related Accession (Same CDS sequence)	NM_175867.3 , NM_175867.2
Accession Version	NM_175867.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1161bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	DNA (cytosine-5)-methyltransferase 3-like isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF194032.1, BC002560.2 and BQ028660.1. On Aug 31, 2019 this sequence version replaced NM_175867.2. Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site at the 3' terminal exon compared to variant 1, which results in an isoform (2) that is 1 aa shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002560.2 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCA TCCCAGCCCT GGACCCAGAG GCCGAGCCCA GCATGGACGT GATTTTGGTG 
GGATCCAGTG AGCTCTCAAG CTCCGTTTCA CCCGGGACAG GCAGAGATCT TATTGCATAT 
GAAGTCAAGG CTAACCAGCG AAATATAGAA GACATCTGCA TCTGCTGCGG AAGTCTCCAG 
GTTCACACAC AGCACCCTCT GTTTGAGGGA GGGATCTGCG CCCCATGTAA GGACAAGTTC 
CTGGATGCCC TCTTCCTGTA CGACGATGAC GGGTACCAAT CCTACTGCTC CATCTGCTGC 
TCCGGAGAGA CGCTGCTCAT CTGCGGAAAC CCTGATTGCA CCCGATGCTA CTGCTTCGAG 
TGTGTGGATA GCCTGGTCGG CCCCGGGACC TCGGGGAAGG TGCACGCCAT GAGCAACTGG 
GTGTGCTACC TGTGCCTGCC GTCCTCCCGA AGCGGGCTGC TGCAGCGTCG GAGGAAGTGG 
CGCAGCCAGC TCAAGGCCTT CTACGACCGA GAGTCGGAGA ATCCCCTTGA GATGTTCGAA 
ACCGTGCCTG TGTGGAGGAG ACAGCCAGTC CGGGTGCTGT CCCTTTTTGA AGACATCAAG 
AAAGAGCTGA CGAGTTTGGG CTTTTTGGAA AGTGGTTCTG ACCCGGGACA ACTGAAGCAT 
GTGGTTGATG TCACAGACAC AGTGAGGAAG GATGTGGAGG AGTGGGGACC CTTCGATCTT 
GTGTACGGCG CCACACCTCC CCTGGGCCAC ACCTGTGACC GTCCTCCCAG CTGGTACCTG 
TTCCAGTTCC ACCGGCTCCT GCAGTACGCA CGGCCCAAGC CAGGCAGCCC CAGGCCCTTC 
TTCTGGATGT TCGTGGACAA TCTGGTGCTG AACAAGGAAG ACCTGGACGT CGCATCTCGC 
TTCCTGGAGA TGGAGCCAGT CACCATCCCA GATGTCCACG GCGGATCCTT GCAGAATGCT 
GTCCGCGTGT GGAGCAACAT CCCAGCCATA AGGAGCAGGC ACTGGGCTCT GGTTTCGGAA 
GAAGAATTGT CCCTGCTGGC CCAGAACAAG CAGAGCTCGA AGCTCGCGGC CAAGTGGCCC 
ACCAAGCTGG TGAAGAACTG CTTTCTCCCC CTAAGAGAAT ATTTCAAGTA TTTTTCAACA 
GAACTCACTT CCTCTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_787063.1
CDS	166..1326
Translation	MAAIPALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQVHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFECVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDRESENPLEMFETVPVWRRQPVRVLSLFEDIKKELTSLGFLESGSDPGQLKHVVDVTDTVRKDVEEWGPFDLVYGATPPLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSRHWALVSEEELSLLAQNKQSSKLAAKWPTKLVKNCFLPLREYFKYFSTELTSSL

Target ORF information:

RefSeq Version	NM_175867.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA methyltransferase 3 like (DNMT3L), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175867.3

ORF Insert Sequence:

ATGGCGGCCA TCCCAGCCCT GGACCCAGAG GCCGAGCCCA GCATGGACGT GATTTTGGTG 
GGATCCAGTG AGCTCTCAAG CTCCGTTTCA CCCGGGACAG GCAGAGATCT TATTGCATAT 
GAAGTCAAGG CTAACCAGCG AAATATAGAA GACATCTGCA TCTGCTGCGG AAGTCTCCAG 
GTTCACACAC AGCACCCTCT GTTTGAGGGA GGGATCTGCG CCCCATGTAA GGACAAGTTC 
CTGGATGCCC TCTTCCTGTA CGACGATGAC GGGTACCAAT CCTACTGCTC CATCTGCTGC 
TCCGGAGAGA CGCTGCTCAT CTGCGGAAAC CCTGATTGCA CCCGATGCTA CTGCTTCGAG 
TGTGTGGATA GCCTGGTCGG CCCCGGGACC TCGGGGAAGG TGCACGCCAT GAGCAACTGG 
GTGTGCTACC TGTGCCTGCC GTCCTCCCGA AGCGGGCTGC TGCAGCGTCG GAGGAAGTGG 
CGCAGCCAGC TCAAGGCCTT CTACGACCGA GAGTCGGAGA ATCCCCTTGA GATGTTCGAA 
ACCGTGCCTG TGTGGAGGAG ACAGCCAGTC CGGGTGCTGT CCCTTTTTGA AGACATCAAG 
AAAGAGCTGA CGAGTTTGGG CTTTTTGGAA AGTGGTTCTG ACCCGGGACA ACTGAAGCAT 
GTGGTTGATG TCACAGACAC AGTGAGGAAG GATGTGGAGG AGTGGGGACC CTTCGATCTT 
GTGTACGGCG CCACACCTCC CCTGGGCCAC ACCTGTGACC GTCCTCCCAG CTGGTACCTG 
TTCCAGTTCC ACCGGCTCCT GCAGTACGCA CGGCCCAAGC CAGGCAGCCC CAGGCCCTTC 
TTCTGGATGT TCGTGGACAA TCTGGTGCTG AACAAGGAAG ACCTGGACGT CGCATCTCGC 
TTCCTGGAGA TGGAGCCAGT CACCATCCCA GATGTCCACG GCGGATCCTT GCAGAATGCT 
GTCCGCGTGT GGAGCAACAT CCCAGCCATA AGGAGCAGGC ACTGGGCTCT GGTTTCGGAA 
GAAGAATTGT CCCTGCTGGC CCAGAACAAG CAGAGCTCGA AGCTCGCGGC CAAGTGGCCC 
ACCAAGCTGG TGAAGAACTG CTTTCTCCCC CTAAGAGAAT ATTTCAAGTA TTTTTCAACA 
GAACTCACTT CCTCTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNMT3L ( NM_175867.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_787063.1 Homo sapiens DNA methyltransferase 3 like (DNMT3L), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07418
Clone ID Related Accession (Same CDS sequence)	NM_175867.3 , NM_175867.2
Accession Version	NM_175867.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1161bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Homo sapiens(human)
Product	DNA (cytosine-5)-methyltransferase 3-like isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF194032.1, BC002560.2 and BQ028660.1. On Jul 3, 2012 this sequence version replaced NM_175867.1. Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site at the 3' terminal exon compared to variant 1, which results in an isoform (2) that is 1 aa shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002560.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2144333 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCA TCCCAGCCCT GGACCCAGAG GCCGAGCCCA GCATGGACGT GATTTTGGTG 
GGATCCAGTG AGCTCTCAAG CTCCGTTTCA CCCGGGACAG GCAGAGATCT TATTGCATAT 
GAAGTCAAGG CTAACCAGCG AAATATAGAA GACATCTGCA TCTGCTGCGG AAGTCTCCAG 
GTTCACACAC AGCACCCTCT GTTTGAGGGA GGGATCTGCG CCCCATGTAA GGACAAGTTC 
CTGGATGCCC TCTTCCTGTA CGACGATGAC GGGTACCAAT CCTACTGCTC CATCTGCTGC 
TCCGGAGAGA CGCTGCTCAT CTGCGGAAAC CCTGATTGCA CCCGATGCTA CTGCTTCGAG 
TGTGTGGATA GCCTGGTCGG CCCCGGGACC TCGGGGAAGG TGCACGCCAT GAGCAACTGG 
GTGTGCTACC TGTGCCTGCC GTCCTCCCGA AGCGGGCTGC TGCAGCGTCG GAGGAAGTGG 
CGCAGCCAGC TCAAGGCCTT CTACGACCGA GAGTCGGAGA ATCCCCTTGA GATGTTCGAA 
ACCGTGCCTG TGTGGAGGAG ACAGCCAGTC CGGGTGCTGT CCCTTTTTGA AGACATCAAG 
AAAGAGCTGA CGAGTTTGGG CTTTTTGGAA AGTGGTTCTG ACCCGGGACA ACTGAAGCAT 
GTGGTTGATG TCACAGACAC AGTGAGGAAG GATGTGGAGG AGTGGGGACC CTTCGATCTT 
GTGTACGGCG CCACACCTCC CCTGGGCCAC ACCTGTGACC GTCCTCCCAG CTGGTACCTG 
TTCCAGTTCC ACCGGCTCCT GCAGTACGCA CGGCCCAAGC CAGGCAGCCC CAGGCCCTTC 
TTCTGGATGT TCGTGGACAA TCTGGTGCTG AACAAGGAAG ACCTGGACGT CGCATCTCGC 
TTCCTGGAGA TGGAGCCAGT CACCATCCCA GATGTCCACG GCGGATCCTT GCAGAATGCT 
GTCCGCGTGT GGAGCAACAT CCCAGCCATA AGGAGCAGGC ACTGGGCTCT GGTTTCGGAA 
GAAGAATTGT CCCTGCTGGC CCAGAACAAG CAGAGCTCGA AGCTCGCGGC CAAGTGGCCC 
ACCAAGCTGG TGAAGAACTG CTTTCTCCCC CTAAGAGAAT ATTTCAAGTA TTTTTCAACA 
GAACTCACTT CCTCTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_787063.1
CDS	485..1645
Translation	MAAIPALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQVHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFECVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDRESENPLEMFETVPVWRRQPVRVLSLFEDIKKELTSLGFLESGSDPGQLKHVVDVTDTVRKDVEEWGPFDLVYGATPPLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSRHWALVSEEELSLLAQNKQSSKLAAKWPTKLVKNCFLPLREYFKYFSTELTSSL

Target ORF information:

RefSeq Version	NM_175867.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA methyltransferase 3 like (DNMT3L), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175867.2

ORF Insert Sequence:

ATGGCGGCCA TCCCAGCCCT GGACCCAGAG GCCGAGCCCA GCATGGACGT GATTTTGGTG 
GGATCCAGTG AGCTCTCAAG CTCCGTTTCA CCCGGGACAG GCAGAGATCT TATTGCATAT 
GAAGTCAAGG CTAACCAGCG AAATATAGAA GACATCTGCA TCTGCTGCGG AAGTCTCCAG 
GTTCACACAC AGCACCCTCT GTTTGAGGGA GGGATCTGCG CCCCATGTAA GGACAAGTTC 
CTGGATGCCC TCTTCCTGTA CGACGATGAC GGGTACCAAT CCTACTGCTC CATCTGCTGC 
TCCGGAGAGA CGCTGCTCAT CTGCGGAAAC CCTGATTGCA CCCGATGCTA CTGCTTCGAG 
TGTGTGGATA GCCTGGTCGG CCCCGGGACC TCGGGGAAGG TGCACGCCAT GAGCAACTGG 
GTGTGCTACC TGTGCCTGCC GTCCTCCCGA AGCGGGCTGC TGCAGCGTCG GAGGAAGTGG 
CGCAGCCAGC TCAAGGCCTT CTACGACCGA GAGTCGGAGA ATCCCCTTGA GATGTTCGAA 
ACCGTGCCTG TGTGGAGGAG ACAGCCAGTC CGGGTGCTGT CCCTTTTTGA AGACATCAAG 
AAAGAGCTGA CGAGTTTGGG CTTTTTGGAA AGTGGTTCTG ACCCGGGACA ACTGAAGCAT 
GTGGTTGATG TCACAGACAC AGTGAGGAAG GATGTGGAGG AGTGGGGACC CTTCGATCTT 
GTGTACGGCG CCACACCTCC CCTGGGCCAC ACCTGTGACC GTCCTCCCAG CTGGTACCTG 
TTCCAGTTCC ACCGGCTCCT GCAGTACGCA CGGCCCAAGC CAGGCAGCCC CAGGCCCTTC 
TTCTGGATGT TCGTGGACAA TCTGGTGCTG AACAAGGAAG ACCTGGACGT CGCATCTCGC 
TTCCTGGAGA TGGAGCCAGT CACCATCCCA GATGTCCACG GCGGATCCTT GCAGAATGCT 
GTCCGCGTGT GGAGCAACAT CCCAGCCATA AGGAGCAGGC ACTGGGCTCT GGTTTCGGAA 
GAAGAATTGT CCCTGCTGGC CCAGAACAAG CAGAGCTCGA AGCTCGCGGC CAAGTGGCCC 
ACCAAGCTGG TGAAGAACTG CTTTCTCCCC CTAAGAGAAT ATTTCAAGTA TTTTTCAACA 
GAACTCACTT CCTCTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNMT3L ( NM_013369.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037501.2 Homo sapiens DNA methyltransferase 3 like (DNMT3L), transcript variant 1, mRNA.

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CloneID	OHu06515
Clone ID Related Accession (Same CDS sequence)	NM_013369.4 , NM_013369.3
Accession Version	NM_013369.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1164bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	DNA (cytosine-5)-methyltransferase 3-like isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF194032.1, BC002560.2 and BQ028660.1. On Jul 3, 2012 this sequence version replaced NM_013369.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF194032.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA1970526 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCA TCCCAGCCCT GGACCCAGAG GCCGAGCCCA GCATGGACGT GATTTTGGTG 
GGATCCAGTG AGCTCTCAAG CTCCGTTTCA CCCGGGACAG GCAGAGATCT TATTGCATAT 
GAAGTCAAGG CTAACCAGCG AAATATAGAA GACATCTGCA TCTGCTGCGG AAGTCTCCAG 
GTTCACACAC AGCACCCTCT GTTTGAGGGA GGGATCTGCG CCCCATGTAA GGACAAGTTC 
CTGGATGCCC TCTTCCTGTA CGACGATGAC GGGTACCAAT CCTACTGCTC CATCTGCTGC 
TCCGGAGAGA CGCTGCTCAT CTGCGGAAAC CCTGATTGCA CCCGATGCTA CTGCTTCGAG 
TGTGTGGATA GCCTGGTCGG CCCCGGGACC TCGGGGAAGG TGCACGCCAT GAGCAACTGG 
GTGTGCTACC TGTGCCTGCC GTCCTCCCGA AGCGGGCTGC TGCAGCGTCG GAGGAAGTGG 
CGCAGCCAGC TCAAGGCCTT CTACGACCGA GAGTCGGAGA ATCCCCTTGA GATGTTCGAA 
ACCGTGCCTG TGTGGAGGAG ACAGCCAGTC CGGGTGCTGT CCCTTTTTGA AGACATCAAG 
AAAGAGCTGA CGAGTTTGGG CTTTTTGGAA AGTGGTTCTG ACCCGGGACA ACTGAAGCAT 
GTGGTTGATG TCACAGACAC AGTGAGGAAG GATGTGGAGG AGTGGGGACC CTTCGATCTT 
GTGTACGGCG CCACACCTCC CCTGGGCCAC ACCTGTGACC GTCCTCCCAG CTGGTACCTG 
TTCCAGTTCC ACCGGCTCCT GCAGTACGCA CGGCCCAAGC CAGGCAGCCC CAGGCCCTTC 
TTCTGGATGT TCGTGGACAA TCTGGTGCTG AACAAGGAAG ACCTGGACGT CGCATCTCGC 
TTCCTGGAGA TGGAGCCAGT CACCATCCCA GATGTCCACG GCGGATCCTT GCAGAATGCT 
GTCCGCGTGT GGAGCAACAT CCCAGCCATA AGGAGCAGCA GGCACTGGGC TCTGGTTTCG 
GAAGAAGAAT TGTCCCTGCT GGCCCAGAAC AAGCAGAGCT CGAAGCTCGC GGCCAAGTGG 
CCCACCAAGC TGGTGAAGAA CTGCTTTCTC CCCCTAAGAG AATATTTCAA GTATTTTTCA 
ACAGAACTCA CTTCCTCTTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037501.2
CDS	485..1648
Translation	MAAIPALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQVHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFECVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDRESENPLEMFETVPVWRRQPVRVLSLFEDIKKELTSLGFLESGSDPGQLKHVVDVTDTVRKDVEEWGPFDLVYGATPPLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSSRHWALVSEEELSLLAQNKQSSKLAAKWPTKLVKNCFLPLREYFKYFSTELTSSL

Target ORF information:

RefSeq Version	NM_013369.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA methyltransferase 3 like (DNMT3L), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013369.3

ORF Insert Sequence:

ATGGCGGCCA TCCCAGCCCT GGACCCAGAG GCCGAGCCCA GCATGGACGT GATTTTGGTG 
GGATCCAGTG AGCTCTCAAG CTCCGTTTCA CCCGGGACAG GCAGAGATCT TATTGCATAT 
GAAGTCAAGG CTAACCAGCG AAATATAGAA GACATCTGCA TCTGCTGCGG AAGTCTCCAG 
GTTCACACAC AGCACCCTCT GTTTGAGGGA GGGATCTGCG CCCCATGTAA GGACAAGTTC 
CTGGATGCCC TCTTCCTGTA CGACGATGAC GGGTACCAAT CCTACTGCTC CATCTGCTGC 
TCCGGAGAGA CGCTGCTCAT CTGCGGAAAC CCTGATTGCA CCCGATGCTA CTGCTTCGAG 
TGTGTGGATA GCCTGGTCGG CCCCGGGACC TCGGGGAAGG TGCACGCCAT GAGCAACTGG 
GTGTGCTACC TGTGCCTGCC GTCCTCCCGA AGCGGGCTGC TGCAGCGTCG GAGGAAGTGG 
CGCAGCCAGC TCAAGGCCTT CTACGACCGA GAGTCGGAGA ATCCCCTTGA GATGTTCGAA 
ACCGTGCCTG TGTGGAGGAG ACAGCCAGTC CGGGTGCTGT CCCTTTTTGA AGACATCAAG 
AAAGAGCTGA CGAGTTTGGG CTTTTTGGAA AGTGGTTCTG ACCCGGGACA ACTGAAGCAT 
GTGGTTGATG TCACAGACAC AGTGAGGAAG GATGTGGAGG AGTGGGGACC CTTCGATCTT 
GTGTACGGCG CCACACCTCC CCTGGGCCAC ACCTGTGACC GTCCTCCCAG CTGGTACCTG 
TTCCAGTTCC ACCGGCTCCT GCAGTACGCA CGGCCCAAGC CAGGCAGCCC CAGGCCCTTC 
TTCTGGATGT TCGTGGACAA TCTGGTGCTG AACAAGGAAG ACCTGGACGT CGCATCTCGC 
TTCCTGGAGA TGGAGCCAGT CACCATCCCA GATGTCCACG GCGGATCCTT GCAGAATGCT 
GTCCGCGTGT GGAGCAACAT CCCAGCCATA AGGAGCAGCA GGCACTGGGC TCTGGTTTCG 
GAAGAAGAAT TGTCCCTGCT GGCCCAGAAC AAGCAGAGCT CGAAGCTCGC GGCCAAGTGG 
CCCACCAAGC TGGTGAAGAA CTGCTTTCTC CCCCTAAGAG AATATTTCAA GTATTTTTCA 
ACAGAACTCA CTTCCTCTTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression.
Human molecular genetics25(9)1714-27(2016 05)
Lu J,Mccarter M,Lian G,Esposito G,Capoccia E,Delli-Bovi LC,Hecht J,Sheen V

Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility.
Molecular medicine reports13(1)1040-6(2016 Jan)
Mostowska A,Szczepa?ska M,Wirstlein P,Skrzypczak J,Jagodzi?ski PP

Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.
Nature517(7536)640-4(2015 Jan)
Guo X,Wang L,Li J,Ding Z,Xiao J,Yin X,He S,Shi P,Dong L,Li G,Tian C,Wang J,Cong Y,Xu Y

DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NF?B complex in the (de-)methylation of TRAF1.
Biochimie10436-49(2014 Sep)
Pacaud R,Sery Q,Oliver L,Vallette FM,Tost J,Cartron PF

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DNMT3L cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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