ALG6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ALG6
Entrez Gene ID	29929
Full Name	ALG6, alpha-1,3-glucosyltransferase
Synonyms	CDG1C
General protein information	Preferred Names ALG6, alpha-1,3-glucosyltransferase Names dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase) asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3-glucosyltransferase) asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog asparagine-linked glycosylation protein 6 homolog dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha- 1->3-glucosyltransferase dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase dolichyl-P-Glc:Man9GlcNAc2-PP-dolichylglucosyltransferase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p31.3
Summary	This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. [provided by RefSeq, Jul 2008].
Disorder MIM:	604566
Disorder Html:	Congenital disorder of glycosylation, type Ic, 603147 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_013339.4	NP_037471.2	dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor
NM_013339.3	NP_037471.2	dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor

Pathways from BioSystems

Homologies

	ALG6	XP_001087054.2
Rattus norvegicus (Norway rat)	Alg6	NP_001028881.1
Gallus gallus (chicken)	ALG6	NP_989766.1
Drosophila melanogaster (fruit fly)	gny	NP_609393.1
Eremothecium gossypii	AGOS_ACR004W	NP_983407.1
Bos taurus (cattle)	ALG6	NP_001068900.2
Danio rerio (zebrafish)	alg6	NP_001003784.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008946	XP_552840.3
Caenorhabditis elegans (roundworm)	C08B11.8	NP_495685.1
Kluyveromyces lactis	KLLA0D01221g	XP_453123.1
Magnaporthe oryzae (rice blast fungus)	MGG_09310	XP_003709962.1
Pan troglodytes (chimpanzee)	ALG6	XP_001160289.1
Canis lupus familiaris (dog)	ALG6	XP_852431.1
Saccharomyces cerevisiae (baker's yeast)	ALG6	NP_014644.1
Homo sapiens (human)	ALG6	NP_037471.2
Mus musculus (house mouse)	Alg6	NP_001074733.1
Schizosaccharomyces pombe (fission yeast)	alg6	NP_596744.1
Neurospora crassa	NCU03317	XP_964494.1
Arabidopsis thaliana (thale cress)	AT5G38460	NP_198662.1
Xenopus tropicalis (tropical clawed frog)	alg6	NP_001011458.1

Gene Ontology
Bibliography

Related articles in PubMed

ALG6-CDG: a recognizable phenotype with epilepsy, proximal muscle weakness, ataxia and behavioral and limb anomalies.
Morava E, Tiemes V, Thiel C, Seta N, de Lonlay P, de Klerk H, Mulder M, Rubio-Gozalbo E, Visser G, van Hasselt P, Horovitz DDG, de Souza CFM, Schwartz IVD, Green A, Al-Owain M, Uziel G, Sigaudy S, Chabrol B, van Spronsen FJ, Steinert M, Komini E, Wurm D, Bevot A, Ayadi A, Huijben K, Dercksen M, Witters P, Jaeken J, Matthijs G, Lefeber DJ, Wevers RA
Journal of inherited metabolic disease39(5)713-723(2016 Sep)

Frequency Determination of ?-1,3 Glucosyltransferase p.Y131H and p.F304S Polymorphisms in the Croatian Population Revealed Five Novel Single Nucleotide Polymorphisms in the hALG6 Gene.
Goreta SS, Dabelic S, Pavlinic D, Lauc G, Dumic J
Genetic testing and molecular biomarkers16(1)50-3(2012 Jan)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Congenital disorder of glycosylation Ic due to a de novo deletion and an hALG-6 mutation.
Eklund EA, Sun L, Yang SP, Pasion RM, Thorland EC, Freeze HH
Biochemical and biophysical research communications339(3)755-60(2006 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ALG6-CDG has been now described in 89 patients.
Title: ALG6-CDG: a recognizable phenotype with epilepsy, proximal muscle weakness, ataxia and behavioral and limb anomalies.

Five novel base substitutions in the hALG6 gene were also found: three in exon 5 (c.383T>C, c.390G>A, and c.429G>C) and two in a downstream intervening sequence (IVS5+17C/T and IVS5+34G/A).
Title: Frequency Determination of ?-1,3 Glucosyltransferase p.Y131H and p.F304S Polymorphisms in the Croatian Population Revealed Five Novel Single Nucleotide Polymorphisms in the hALG6 Gene.

Our findings extend the causes of CDG to larger DNA deletions and identify the first Japanese CDG-Ic mutation.
Title: Congenital disorder of glycosylation Ic due to a de novo deletion and an hALG-6 mutation.

A frequent mild mutation in ALG6 may exacerbate the clinical severity of patients with congenital disorder of glycosylation Ia (CDG-Ia) caused by phosphomannomutase deficiency.
Title: A frequent mild mutation in ALG6 may exacerbate the clinical severity of patients with congenital disorder of glycosylation Ia (CDG-Ia) caused by phosphomannomutase deficiency.

The following ALG6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALG6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19091	NM_013339.4 Latest version!	Homo sapiens ALG6 alpha-1,3-glucosyltransferase (ALG6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu19091	NM_013339.3	Homo sapiens ALG6, alpha-1,3-glucosyltransferase (ALG6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ALG6 ( NM_013339.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037471.2 Homo sapiens ALG6 alpha-1,3-glucosyltransferase (ALG6), mRNA.

Price & Availability↑

CloneID	OHu19091
Clone ID Related Accession (Same CDS sequence)	NM_013339.4 , NM_013339.3
Accession Version	NM_013339.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI819904.1, BC001253.1 and AL592218.8. This sequence is a reference standard in the RefSeqGene project. On Jul 30, 2018 this sequence version replaced NM_013339.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.116787.1, SRR1803612.162459.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000263440.6/ ENSP00000263440.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAAT GGTACTTGAT GACAGTAGTG GTTTTAATAG GACTAACAGT ACGATGGACA 
GTGTCTCTTA ATTCTTATTC AGGTGCTGGT AAACCGCCTA TGTTTGGTGA TTATGAAGCT 
CAGAGACACT GGCAAGAAAT AACTTTTAAT TTACCGGTCA AACAATGGTA TTTTAACAGC 
AGTGATAACA ATTTACAGTA TTGGGGATTG GATTACCCAC CTCTTACAGC TTATCATAGT 
CTCCTATGTG CATATGTGGC AAAGTTTATA AATCCAGACT GGATTGCTCT CCATACATCA 
CGTGGATATG AGAGTCAGGC ACATAAGCTC TTCATGCGTA CAACAGTTTT AATTGCTGAT 
CTGCTGATTT ACATACCTGC AGTGGTTTTG TACTGTTGTT GCTTAAAAGA AATCTCAACT 
AAGAAAAAGA TTGCTAATGC ATTATGCATC TTGCTGTATC CAGGCCTTAT TCTTATAGAC 
TATGGACATT TTCAATATAA TTCTGTGAGT CTTGGCTTTG CTTTGTGGGG TGTTCTTGGA 
ATATCTTGTG ACTGCGACCT CCTAGGGTCA CTGGCATTTT GCTTAGCTAT AAATTATAAA 
CAGATGGAAC TTTACCACGC CTTGCCATTT TTTTGCTTTT TACTTGGCAA GTGTTTTAAA 
AAAGGCCTCA AAGGAAAGGG GTTTGTGTTG CTAGTTAAGC TAGCTTGTAT TGTTGTGGCT 
TCCTTCGTTC TCTGCTGGCT GCCATTCTTT ACAGAAAGGG AACAAACCCT GCAGGTTCTA 
AGAAGACTCT TCCCGGTTGA TCGTGGATTA TTTGAGGATA AAGTAGCCAA TATTTGGTGC 
AGCTTCAATG TCTTTCTGAA GATTAAGGAT ATTTTGCCAC GTCACATCCA ATTAATAATG 
AGCTTTTGTT CTACGTTTTT GAGCCTGCTT CCTGCATGCA TAAAATTAAT ACTTCAGCCC 
TCTTCCAAAG GATTCAAATT TACACTGGTT AGCTGTGCGC TATCATTCTT TTTATTTTCT 
TTCCAAGTAC ATGAAAAATC CATTCTCTTG GTGTCACTAC CAGTCTGCTT AGTTTTAAGT 
GAAATTCCTT TTATGTCTAC TTGGTTTTTA CTTGTGTCAA CATTTAGTAT GCTACCTCTT 
CTATTGAAGG ATGAACTCCT AATGCCCTCT GTTGTGACAA CAATGGCATT TTTTATAGCT 
TGTGTAACTT CCTTTTCAAT ATTTGAAAAG ACTTCTGAAG AAGAACTGCA GTTGAAATCC 
TTTTCCATTT CTGTGAGGAA ATATCTTCCA TGTTTTACAT TTCTTTCCAG AATTATACAA 
TATTTGTTTC TTATCTCAGT CATCACTATG GTGCTTCTGA CGTTGATGAC TGTCACACTG 
GATCCTCCTC AGAAACTACC GGACTTGTTT TCTGTATTGG TGTGTTTTGT ATCTTGCTTG 
AACTTCCTGT TCTTCTTGGT ATACTTTAAC ATTATTATTA TGTGGGATTC CAAAAGTGGA 
AGAAATCAGA AGAAAATCAG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037471.2
CDS	269..1792
Translation	MEKWYLMTVVVLIGLTVRWTVSLNSYSGAGKPPMFGDYEAQRHWQEITFNLPVKQWYFNSSDNNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWIALHTSRGYESQAHKLFMRTTVLIADLLIYIPAVVLYCCCLKEISTKKKIANALCILLYPGLILIDYGHFQYNSVSLGFALWGVLGISCDCDLLGSLAFCLAINYKQMELYHALPFFCFLLGKCFKKGLKGKGFVLLVKLACIVVASFVLCWLPFFTEREQTLQVLRRLFPVDRGLFEDKVANIWCSFNVFLKIKDILPRHIQLIMSFCSTFLSLLPACIKLILQPSSKGFKFTLVSCALSFFLFSFQVHEKSILLVSLPVCLVLSEIPFMSTWFLLVSTFSMLPLLLKDELLMPSVVTTMAFFIACVTSFSIFEKTSEEELQLKSFSISVRKYLPCFTFLSRIIQYLFLISVITMVLLTLMTVTLDPPQKLPDLFSVLVCFVSCLNFLFFLVYFNIIIMWDSKSGRNQKKIS

Target ORF information:

RefSeq Version	NM_013339.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ALG6 alpha-1,3-glucosyltransferase (ALG6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013339.4

ORF Insert Sequence:

ATGGAGAAAT GGTACTTGAT GACAGTAGTG GTTTTAATAG GACTAACAGT ACGATGGACA 
GTGTCTCTTA ATTCTTATTC AGGTGCTGGT AAACCGCCTA TGTTTGGTGA TTATGAAGCT 
CAGAGACACT GGCAAGAAAT AACTTTTAAT TTACCGGTCA AACAATGGTA TTTTAACAGC 
AGTGATAACA ATTTACAGTA TTGGGGATTG GATTACCCAC CTCTTACAGC TTATCATAGT 
CTCCTATGTG CATATGTGGC AAAGTTTATA AATCCAGACT GGATTGCTCT CCATACATCA 
CGTGGATATG AGAGTCAGGC ACATAAGCTC TTCATGCGTA CAACAGTTTT AATTGCTGAT 
CTGCTGATTT ACATACCTGC AGTGGTTTTG TACTGTTGTT GCTTAAAAGA AATCTCAACT 
AAGAAAAAGA TTGCTAATGC ATTATGCATC TTGCTGTATC CAGGCCTTAT TCTTATAGAC 
TATGGACATT TTCAATATAA TTCTGTGAGT CTTGGCTTTG CTTTGTGGGG TGTTCTTGGA 
ATATCTTGTG ACTGCGACCT CCTAGGGTCA CTGGCATTTT GCTTAGCTAT AAATTATAAA 
CAGATGGAAC TTTACCACGC CTTGCCATTT TTTTGCTTTT TACTTGGCAA GTGTTTTAAA 
AAAGGCCTCA AAGGAAAGGG GTTTGTGTTG CTAGTTAAGC TAGCTTGTAT TGTTGTGGCT 
TCCTTCGTTC TCTGCTGGCT GCCATTCTTT ACAGAAAGGG AACAAACCCT GCAGGTTCTA 
AGAAGACTCT TCCCGGTTGA TCGTGGATTA TTTGAGGATA AAGTAGCCAA TATTTGGTGC 
AGCTTCAATG TCTTTCTGAA GATTAAGGAT ATTTTGCCAC GTCACATCCA ATTAATAATG 
AGCTTTTGTT CTACGTTTTT GAGCCTGCTT CCTGCATGCA TAAAATTAAT ACTTCAGCCC 
TCTTCCAAAG GATTCAAATT TACACTGGTT AGCTGTGCGC TATCATTCTT TTTATTTTCT 
TTCCAAGTAC ATGAAAAATC CATTCTCTTG GTGTCACTAC CAGTCTGCTT AGTTTTAAGT 
GAAATTCCTT TTATGTCTAC TTGGTTTTTA CTTGTGTCAA CATTTAGTAT GCTACCTCTT 
CTATTGAAGG ATGAACTCCT AATGCCCTCT GTTGTGACAA CAATGGCATT TTTTATAGCT 
TGTGTAACTT CCTTTTCAAT ATTTGAAAAG ACTTCTGAAG AAGAACTGCA GTTGAAATCC 
TTTTCCATTT CTGTGAGGAA ATATCTTCCA TGTTTTACAT TTCTTTCCAG AATTATACAA 
TATTTGTTTC TTATCTCAGT CATCACTATG GTGCTTCTGA CGTTGATGAC TGTCACACTG 
GATCCTCCTC AGAAACTACC GGACTTGTTT TCTGTATTGG TGTGTTTTGT ATCTTGCTTG 
AACTTCCTGT TCTTCTTGGT ATACTTTAAC ATTATTATTA TGTGGGATTC CAAAAGTGGA 
AGAAATCAGA AGAAAATCAG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALG6 ( NM_013339.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037471.2 Homo sapiens ALG6, alpha-1,3-glucosyltransferase (ALG6), mRNA.

Price & Availability↑

CloneID	OHu19091
Clone ID Related Accession (Same CDS sequence)	NM_013339.4 , NM_013339.3
Accession Version	NM_013339.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI819904.1, BC001253.1 and AL592218.8. This sequence is a reference standard in the RefSeqGene project. On Nov 29, 2008 this sequence version replaced NM_013339.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.116787.1, SRR1660803.249890.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAAT GGTACTTGAT GACAGTAGTG GTTTTAATAG GACTAACAGT ACGATGGACA 
GTGTCTCTTA ATTCTTATTC AGGTGCTGGT AAACCGCCTA TGTTTGGTGA TTATGAAGCT 
CAGAGACACT GGCAAGAAAT AACTTTTAAT TTACCGGTCA AACAATGGTA TTTTAACAGC 
AGTGATAACA ATTTACAGTA TTGGGGATTG GATTACCCAC CTCTTACAGC TTATCATAGT 
CTCCTATGTG CATATGTGGC AAAGTTTATA AATCCAGACT GGATTGCTCT CCATACATCA 
CGTGGATATG AGAGTCAGGC ACATAAGCTC TTCATGCGTA CAACAGTTTT AATTGCTGAT 
CTGCTGATTT ACATACCTGC AGTGGTTTTG TACTGTTGTT GCTTAAAAGA AATCTCAACT 
AAGAAAAAGA TTGCTAATGC ATTATGCATC TTGCTGTATC CAGGCCTTAT TCTTATAGAC 
TATGGACATT TTCAATATAA TTCTGTGAGT CTTGGCTTTG CTTTGTGGGG TGTTCTTGGA 
ATATCTTGTG ACTGCGACCT CCTAGGGTCA CTGGCATTTT GCTTAGCTAT AAATTATAAA 
CAGATGGAAC TTTACCACGC CTTGCCATTT TTTTGCTTTT TACTTGGCAA GTGTTTTAAA 
AAAGGCCTCA AAGGAAAGGG GTTTGTGTTG CTAGTTAAGC TAGCTTGTAT TGTTGTGGCT 
TCCTTCGTTC TCTGCTGGCT GCCATTCTTT ACAGAAAGGG AACAAACCCT GCAGGTTCTA 
AGAAGACTCT TCCCGGTTGA TCGTGGATTA TTTGAGGATA AAGTAGCCAA TATTTGGTGC 
AGCTTCAATG TCTTTCTGAA GATTAAGGAT ATTTTGCCAC GTCACATCCA ATTAATAATG 
AGCTTTTGTT CTACGTTTTT GAGCCTGCTT CCTGCATGCA TAAAATTAAT ACTTCAGCCC 
TCTTCCAAAG GATTCAAATT TACACTGGTT AGCTGTGCGC TATCATTCTT TTTATTTTCT 
TTCCAAGTAC ATGAAAAATC CATTCTCTTG GTGTCACTAC CAGTCTGCTT AGTTTTAAGT 
GAAATTCCTT TTATGTCTAC TTGGTTTTTA CTTGTGTCAA CATTTAGTAT GCTACCTCTT 
CTATTGAAGG ATGAACTCCT AATGCCCTCT GTTGTGACAA CAATGGCATT TTTTATAGCT 
TGTGTAACTT CCTTTTCAAT ATTTGAAAAG ACTTCTGAAG AAGAACTGCA GTTGAAATCC 
TTTTCCATTT CTGTGAGGAA ATATCTTCCA TGTTTTACAT TTCTTTCCAG AATTATACAA 
TATTTGTTTC TTATCTCAGT CATCACTATG GTGCTTCTGA CGTTGATGAC TGTCACACTG 
GATCCTCCTC AGAAACTACC GGACTTGTTT TCTGTATTGG TGTGTTTTGT ATCTTGCTTG 
AACTTCCTGT TCTTCTTGGT ATACTTTAAC ATTATTATTA TGTGGGATTC CAAAAGTGGA 
AGAAATCAGA AGAAAATCAG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037471.2
CDS	306..1829
Translation	MEKWYLMTVVVLIGLTVRWTVSLNSYSGAGKPPMFGDYEAQRHWQEITFNLPVKQWYFNSSDNNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWIALHTSRGYESQAHKLFMRTTVLIADLLIYIPAVVLYCCCLKEISTKKKIANALCILLYPGLILIDYGHFQYNSVSLGFALWGVLGISCDCDLLGSLAFCLAINYKQMELYHALPFFCFLLGKCFKKGLKGKGFVLLVKLACIVVASFVLCWLPFFTEREQTLQVLRRLFPVDRGLFEDKVANIWCSFNVFLKIKDILPRHIQLIMSFCSTFLSLLPACIKLILQPSSKGFKFTLVSCALSFFLFSFQVHEKSILLVSLPVCLVLSEIPFMSTWFLLVSTFSMLPLLLKDELLMPSVVTTMAFFIACVTSFSIFEKTSEEELQLKSFSISVRKYLPCFTFLSRIIQYLFLISVITMVLLTLMTVTLDPPQKLPDLFSVLVCFVSCLNFLFFLVYFNIIIMWDSKSGRNQKKIS

Target ORF information:

RefSeq Version	NM_013339.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ALG6, alpha-1,3-glucosyltransferase (ALG6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013339.3

ORF Insert Sequence:

ATGGAGAAAT GGTACTTGAT GACAGTAGTG GTTTTAATAG GACTAACAGT ACGATGGACA 
GTGTCTCTTA ATTCTTATTC AGGTGCTGGT AAACCGCCTA TGTTTGGTGA TTATGAAGCT 
CAGAGACACT GGCAAGAAAT AACTTTTAAT TTACCGGTCA AACAATGGTA TTTTAACAGC 
AGTGATAACA ATTTACAGTA TTGGGGATTG GATTACCCAC CTCTTACAGC TTATCATAGT 
CTCCTATGTG CATATGTGGC AAAGTTTATA AATCCAGACT GGATTGCTCT CCATACATCA 
CGTGGATATG AGAGTCAGGC ACATAAGCTC TTCATGCGTA CAACAGTTTT AATTGCTGAT 
CTGCTGATTT ACATACCTGC AGTGGTTTTG TACTGTTGTT GCTTAAAAGA AATCTCAACT 
AAGAAAAAGA TTGCTAATGC ATTATGCATC TTGCTGTATC CAGGCCTTAT TCTTATAGAC 
TATGGACATT TTCAATATAA TTCTGTGAGT CTTGGCTTTG CTTTGTGGGG TGTTCTTGGA 
ATATCTTGTG ACTGCGACCT CCTAGGGTCA CTGGCATTTT GCTTAGCTAT AAATTATAAA 
CAGATGGAAC TTTACCACGC CTTGCCATTT TTTTGCTTTT TACTTGGCAA GTGTTTTAAA 
AAAGGCCTCA AAGGAAAGGG GTTTGTGTTG CTAGTTAAGC TAGCTTGTAT TGTTGTGGCT 
TCCTTCGTTC TCTGCTGGCT GCCATTCTTT ACAGAAAGGG AACAAACCCT GCAGGTTCTA 
AGAAGACTCT TCCCGGTTGA TCGTGGATTA TTTGAGGATA AAGTAGCCAA TATTTGGTGC 
AGCTTCAATG TCTTTCTGAA GATTAAGGAT ATTTTGCCAC GTCACATCCA ATTAATAATG 
AGCTTTTGTT CTACGTTTTT GAGCCTGCTT CCTGCATGCA TAAAATTAAT ACTTCAGCCC 
TCTTCCAAAG GATTCAAATT TACACTGGTT AGCTGTGCGC TATCATTCTT TTTATTTTCT 
TTCCAAGTAC ATGAAAAATC CATTCTCTTG GTGTCACTAC CAGTCTGCTT AGTTTTAAGT 
GAAATTCCTT TTATGTCTAC TTGGTTTTTA CTTGTGTCAA CATTTAGTAT GCTACCTCTT 
CTATTGAAGG ATGAACTCCT AATGCCCTCT GTTGTGACAA CAATGGCATT TTTTATAGCT 
TGTGTAACTT CCTTTTCAAT ATTTGAAAAG ACTTCTGAAG AAGAACTGCA GTTGAAATCC 
TTTTCCATTT CTGTGAGGAA ATATCTTCCA TGTTTTACAT TTCTTTCCAG AATTATACAA 
TATTTGTTTC TTATCTCAGT CATCACTATG GTGCTTCTGA CGTTGATGAC TGTCACACTG 
GATCCTCCTC AGAAACTACC GGACTTGTTT TCTGTATTGG TGTGTTTTGT ATCTTGCTTG 
AACTTCCTGT TCTTCTTGGT ATACTTTAAC ATTATTATTA TGTGGGATTC CAAAAGTGGA 
AGAAATCAGA AGAAAATCAG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ALG6-CDG: a recognizable phenotype with epilepsy, proximal muscle weakness, ataxia and behavioral and limb anomalies.
Journal of inherited metabolic disease39(5)713-723(2016 Sep)
Morava E,Tiemes V,Thiel C,Seta N,de Lonlay P,de Klerk H,Mulder M,Rubio-Gozalbo E,Visser G,van Hasselt P,Horovitz DDG,de Souza CFM,Schwartz IVD,Green A,Al-Owain M,Uziel G,Sigaudy S,Chabrol B,van Spronsen FJ,Steinert M,Komini E,Wurm D,Bevot A,Ayadi A,Huijben K,Dercksen M,Witters P,Jaeken J,Matthijs G,Lefeber DJ,Wevers RA

Frequency Determination of ?-1,3 Glucosyltransferase p.Y131H and p.F304S Polymorphisms in the Croatian Population Revealed Five Novel Single Nucleotide Polymorphisms in the hALG6 Gene.
Genetic testing and molecular biomarkers16(1)50-3(2012 Jan)
Goreta SS,Dabelic S,Pavlinic D,Lauc G,Dumic J

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Congenital disorder of glycosylation Ic due to a de novo deletion and an hALG-6 mutation.
Biochemical and biophysical research communications339(3)755-60(2006 Jan)
Eklund EA,Sun L,Yang SP,Pasion RM,Thorland EC,Freeze HH

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ALG6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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