SNX15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SNX15
Entrez Gene ID	29907
Full Name	sorting nexin 15
Synonyms	HSAF001435
General protein information	Preferred Names sorting nexin 15 Names sorting nexin-15 clone iota unknown protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.1
Summary	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010].
Disorder MIM:	605964

mRNA and Protein(s)

mRNA	Protein	Name
NM_147777.3	NP_680086.2	sorting nexin-15 isoform B
NM_147777.4	NP_680086.2	sorting nexin-15 isoform B
NM_013306.4	NP_037438.2	sorting nexin-15 isoform A
NM_013306.5	NP_037438.2	sorting nexin-15 isoform A

Pathways from BioSystems

Homologies

	SNX15	XP_001114653.2
Rattus norvegicus (Norway rat)	Snx15	NP_001019923.1
Pan troglodytes (chimpanzee)	SNX15	XP_003339254.1
Canis lupus familiaris (dog)	SNX15	XP_854899.1
Mus musculus (house mouse)	Snx15	NP_081188.1
Xenopus tropicalis (tropical clawed frog)	snx15	NP_001093667.1
Homo sapiens (human)	SNX15	NP_037438.2
Bos taurus (cattle)	SNX15	NP_001068798.1
Danio rerio (zebrafish)	snx15	NP_001104707.1

Gene Ontology
Bibliography

Related articles in PubMed

SNX15 Regulates Cell Surface Recycling of APP and A? Generation.
Feng T, Niu M, Ji C, Gao Y, Wen J, Bu G, Xu H, Zhang YW
Molecular neurobiology53(6)3690-3701(2016 Aug)

SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome.
Danson C, Brown E, Hemmings OJ, McGough IJ, Yarwood S, Heesom KJ, Carlton JG, Martin-Serrano J, May MT, Verkade P, Cullen PJ
Journal of cell science126(Pt 21)4885-99(2013 Nov)

Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)

Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.
Wang W, Shen P, Thiyagarajan S, Lin S, Palm C, Horvath R, Klopstock T, Cutler D, Pique L, Schrijver I, Davis RW, Mindrinos M, Speed TP, Scharfe C
Nucleic acids research39(1)44-58(2011 Jan)

A clinical, genetic and candidate gene study of Silver syndrome, a complicated form of hereditary spastic paraplegia.
Warner TT, Patel H, Proukakis C, Reed JA, McKie L, Wills A, Patton MA, Crosby AH
Journal of neurology251(9)1068-74(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SNX15 regulates the recycling of APP to cell surface and, thus, its processing for Abeta generation.
Title: SNX15 Regulates Cell Surface Recycling of APP and A? Generation.

The activated EGF receptor enters distinct sub-populations of SNX15- and APPL1-labelled peripheral endocytic vesicles.
Title: SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome.

The following SNX15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNX15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18233	NM_013306.5 Latest version!	Homo sapiens sorting nexin 15 (SNX15), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu06659	NM_147777.4 Latest version!	Homo sapiens sorting nexin 15 (SNX15), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu06659	NM_147777.3	Homo sapiens sorting nexin 15 (SNX15), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu18233	NM_013306.4	Homo sapiens sorting nexin 15 (SNX15), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SNX15 ( NM_013306.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037438.2 Homo sapiens sorting nexin 15 (SNX15), transcript variant A, mRNA.

Price & Availability↑

CloneID	OHu18233
Clone ID Related Accession (Same CDS sequence)	NM_013306.4 , NM_013306.5
Accession Version	NM_013306.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1029bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	sorting nexin-15 isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA079695.1 and BC014520.2. This sequence is a reference standard in the RefSeqGene project. On Dec 15, 2010 this sequence version replaced NM_013306.3. Transcript Variant: This variant (A, also known as SNX15) represents the longer transcript and encodes the longer isoform (A). ##Evidence-Data-START## Transcript exon combination :: BC012767.2, SRR1163658.455825.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCGCC AGGCGAAGGA TGACTTCCTG CGGCACTACA CAGTGTCGGA CCCCAGGACT 
CACCCCAAGG GCTACACCGA GTACAAAGTA ACCGCGCAGT TCATCTCAAA GAAGGACCCA 
GAGGATGTCA AAGAGGTGGT GGTCTGGAAG CGGTACAGCG ACTTCCGCAA GCTGCATGGA 
GACCTGGCCT ACACCCACCG CAACCTCTTC CGCCGCCTCG AGGAGTTCCC TGCTTTCCCC 
CGGGCCCAGG TGTTTGGCCG GTTTGAAGCC TCAGTGATCG AGGAGCGGCG AAAGGGGGCA 
GAGGACCTGC TTCGCTTCAC TGTGCACATA CCTGCGCTCA ACAACAGCCC CCAGCTCAAG 
GAGTTCTTCC GGGGTGGGGA GGTGACCCGA CCCTTGGAGG TGTCCAGGGA CCTACACATC 
CTGCCACCCC CTCTGATCCC CACCCCGCCC CCTGATGACC CCCGGCTATC CCAACTGCTC 
CCTGCAGAAA GGAGGGGCCT CGAGGAATTG GAGGTGCCAG TGGACCCCCC ACCATCCAGC 
CCTGCCCAGG AGGCCCTGGA TCTCCTCTTT AACTGTGAGA GCACCGAGGA GGCATCTGGT 
TCCCCTGCCC GAGGCCCCCT CACCGAGGCT GAGCTTGCCC TCTTCGACCC CTTCTCCAAG 
GAAGAAGGCG CAGCCCCCAG CCCCACCCAT GTGGCTGAGC TGGCAACGAT GGAGGTGGAG 
TCTGCAAGGC TGGACCAGGA ACCCTGGGAG CCAGGAGGGC AGGAGGAGGA AGAGGATGGG 
GAAGGAGGGC CCACCCCTGC CTACCTAAGC CAGGCCACAG AGCTCATCAC CCAGGCCCTG 
CGGGATGAGA AGGCAGGCGC TTACGCTGCT GCACTCCAGG GCTATCGAGA CGGCGTGCAC 
GTCTTGCTTC AGGGAGTCCC CAGTGACCCG TTGCCTGCCC GCCAGGAAGG TGTGAAGAAG 
AAGGCAGCTG AGTACCTGAA GCGGGCAGAG GAGATCCTGC GCCTGCACCT GTCTCAACTC 
CCACCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037438.2
CDS	131..1159
Translation	MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDPPPSSPAQEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEEGAAPSPTHVAELATMEVESARLDQEPWEPGGQEEEEDGEGGPTPAYLSQATELITQALRDEKAGAYAAALQGYRDGVHVLLQGVPSDPLPARQEGVKKKAAEYLKRAEEILRLHLSQLPP

Target ORF information:

RefSeq Version	NM_013306.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sorting nexin 15 (SNX15), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013306.4

ORF Insert Sequence:

ATGTCCCGCC AGGCGAAGGA TGACTTCCTG CGGCACTACA CAGTGTCGGA CCCCAGGACT 
CACCCCAAGG GCTACACCGA GTACAAAGTA ACCGCGCAGT TCATCTCAAA GAAGGACCCA 
GAGGATGTCA AAGAGGTGGT GGTCTGGAAG CGGTACAGCG ACTTCCGCAA GCTGCATGGA 
GACCTGGCCT ACACCCACCG CAACCTCTTC CGCCGCCTCG AGGAGTTCCC TGCTTTCCCC 
CGGGCCCAGG TGTTTGGCCG GTTTGAAGCC TCAGTGATCG AGGAGCGGCG AAAGGGGGCA 
GAGGACCTGC TTCGCTTCAC TGTGCACATA CCTGCGCTCA ACAACAGCCC CCAGCTCAAG 
GAGTTCTTCC GGGGTGGGGA GGTGACCCGA CCCTTGGAGG TGTCCAGGGA CCTACACATC 
CTGCCACCCC CTCTGATCCC CACCCCGCCC CCTGATGACC CCCGGCTATC CCAACTGCTC 
CCTGCAGAAA GGAGGGGCCT CGAGGAATTG GAGGTGCCAG TGGACCCCCC ACCATCCAGC 
CCTGCCCAGG AGGCCCTGGA TCTCCTCTTT AACTGTGAGA GCACCGAGGA GGCATCTGGT 
TCCCCTGCCC GAGGCCCCCT CACCGAGGCT GAGCTTGCCC TCTTCGACCC CTTCTCCAAG 
GAAGAAGGCG CAGCCCCCAG CCCCACCCAT GTGGCTGAGC TGGCAACGAT GGAGGTGGAG 
TCTGCAAGGC TGGACCAGGA ACCCTGGGAG CCAGGAGGGC AGGAGGAGGA AGAGGATGGG 
GAAGGAGGGC CCACCCCTGC CTACCTAAGC CAGGCCACAG AGCTCATCAC CCAGGCCCTG 
CGGGATGAGA AGGCAGGCGC TTACGCTGCT GCACTCCAGG GCTATCGAGA CGGCGTGCAC 
GTCTTGCTTC AGGGAGTCCC CAGTGACCCG TTGCCTGCCC GCCAGGAAGG TGTGAAGAAG 
AAGGCAGCTG AGTACCTGAA GCGGGCAGAG GAGATCCTGC GCCTGCACCT GTCTCAACTC 
CCACCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNX15 ( NM_013306.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_037438.2 Homo sapiens sorting nexin 15 (SNX15), transcript variant A, mRNA.

Price & Availability↑

CloneID	OHu18233
Clone ID Related Accession (Same CDS sequence)	NM_013306.4 , NM_013306.5
Accession Version	NM_013306.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1029bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	sorting nexin-15 isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000436.5 and AP003068.3. On Nov 23, 2018 this sequence version replaced NM_013306.4. Transcript Variant: This variant (A, also known as SNX15) represents the longer transcript and encodes the longer isoform (A). ##Evidence-Data-START## Transcript exon combination :: BC012767.2, SRR3476690.828136.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000377244.8/ ENSP00000366452.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCCGCC AGGCGAAGGA TGACTTCCTG CGGCACTACA CAGTGTCGGA CCCCAGGACT 
CACCCCAAGG GCTACACCGA GTACAAAGTA ACCGCGCAGT TCATCTCAAA GAAGGACCCA 
GAGGATGTCA AAGAGGTGGT GGTCTGGAAG CGGTACAGCG ACTTCCGCAA GCTGCATGGA 
GACCTGGCCT ACACCCACCG CAACCTCTTC CGCCGCCTCG AGGAGTTCCC TGCTTTCCCC 
CGGGCCCAGG TGTTTGGCCG GTTTGAAGCC TCAGTGATCG AGGAGCGGCG AAAGGGGGCA 
GAGGACCTGC TTCGCTTCAC TGTGCACATA CCTGCGCTCA ACAACAGCCC CCAGCTCAAG 
GAGTTCTTCC GGGGTGGGGA GGTGACCCGA CCCTTGGAGG TGTCCAGGGA CCTACACATC 
CTGCCACCCC CTCTGATCCC CACCCCGCCC CCTGATGACC CCCGGCTATC CCAACTGCTC 
CCTGCAGAAA GGAGGGGCCT CGAGGAATTG GAGGTGCCAG TGGACCCCCC ACCATCCAGC 
CCTGCCCAGG AGGCCCTGGA TCTCCTCTTT AACTGTGAGA GCACCGAGGA GGCATCTGGT 
TCCCCTGCCC GAGGCCCCCT CACCGAGGCT GAGCTTGCCC TCTTCGACCC CTTCTCCAAG 
GAAGAAGGCG CAGCCCCCAG CCCCACCCAT GTGGCTGAGC TGGCAACGAT GGAGGTGGAG 
TCTGCAAGGC TGGACCAGGA ACCCTGGGAG CCAGGAGGGC AGGAGGAGGA AGAGGATGGG 
GAAGGAGGGC CCACCCCTGC CTACCTAAGC CAGGCCACAG AGCTCATCAC CCAGGCCCTG 
CGGGATGAGA AGGCAGGCGC TTACGCTGCT GCACTCCAGG GCTATCGAGA CGGCGTGCAC 
GTCTTGCTTC AGGGAGTCCC CAGTGACCCG TTGCCTGCCC GCCAGGAAGG TGTGAAGAAG 
AAGGCAGCTG AGTACCTGAA GCGGGCAGAG GAGATCCTGC GCCTGCACCT GTCTCAACTC 
CCACCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037438.2
CDS	100..1128
Translation	MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDPPPSSPAQEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEEGAAPSPTHVAELATMEVESARLDQEPWEPGGQEEEEDGEGGPTPAYLSQATELITQALRDEKAGAYAAALQGYRDGVHVLLQGVPSDPLPARQEGVKKKAAEYLKRAEEILRLHLSQLPP

Target ORF information:

RefSeq Version	NM_013306.5
Organism	Homo sapiens(human)
Definition	Homo sapiens sorting nexin 15 (SNX15), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013306.5

ORF Insert Sequence:

ATGTCCCGCC AGGCGAAGGA TGACTTCCTG CGGCACTACA CAGTGTCGGA CCCCAGGACT 
CACCCCAAGG GCTACACCGA GTACAAAGTA ACCGCGCAGT TCATCTCAAA GAAGGACCCA 
GAGGATGTCA AAGAGGTGGT GGTCTGGAAG CGGTACAGCG ACTTCCGCAA GCTGCATGGA 
GACCTGGCCT ACACCCACCG CAACCTCTTC CGCCGCCTCG AGGAGTTCCC TGCTTTCCCC 
CGGGCCCAGG TGTTTGGCCG GTTTGAAGCC TCAGTGATCG AGGAGCGGCG AAAGGGGGCA 
GAGGACCTGC TTCGCTTCAC TGTGCACATA CCTGCGCTCA ACAACAGCCC CCAGCTCAAG 
GAGTTCTTCC GGGGTGGGGA GGTGACCCGA CCCTTGGAGG TGTCCAGGGA CCTACACATC 
CTGCCACCCC CTCTGATCCC CACCCCGCCC CCTGATGACC CCCGGCTATC CCAACTGCTC 
CCTGCAGAAA GGAGGGGCCT CGAGGAATTG GAGGTGCCAG TGGACCCCCC ACCATCCAGC 
CCTGCCCAGG AGGCCCTGGA TCTCCTCTTT AACTGTGAGA GCACCGAGGA GGCATCTGGT 
TCCCCTGCCC GAGGCCCCCT CACCGAGGCT GAGCTTGCCC TCTTCGACCC CTTCTCCAAG 
GAAGAAGGCG CAGCCCCCAG CCCCACCCAT GTGGCTGAGC TGGCAACGAT GGAGGTGGAG 
TCTGCAAGGC TGGACCAGGA ACCCTGGGAG CCAGGAGGGC AGGAGGAGGA AGAGGATGGG 
GAAGGAGGGC CCACCCCTGC CTACCTAAGC CAGGCCACAG AGCTCATCAC CCAGGCCCTG 
CGGGATGAGA AGGCAGGCGC TTACGCTGCT GCACTCCAGG GCTATCGAGA CGGCGTGCAC 
GTCTTGCTTC AGGGAGTCCC CAGTGACCCG TTGCCTGCCC GCCAGGAAGG TGTGAAGAAG 
AAGGCAGCTG AGTACCTGAA GCGGGCAGAG GAGATCCTGC GCCTGCACCT GTCTCAACTC 
CCACCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNX15 ( NM_147777.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_680086.2 Homo sapiens sorting nexin 15 (SNX15), transcript variant B, mRNA.

Price & Availability↑

CloneID	OHu06659
Clone ID Related Accession (Same CDS sequence)	NM_147777.3 , NM_147777.4
Accession Version	NM_147777.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	sorting nexin-15 isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA079695.1, AF175268.1, BC014520.2 and BE884806.1. On Dec 15, 2010 this sequence version replaced NM_147777.2. Transcript Variant: This variant (B, also known as SNX15A) lacks an alternate in-frame exon in the 3' coding region, compared to variant A, resulting in an isoform (B) that is shorter than isoform A. ##Evidence-Data-START## Transcript exon combination :: ERR279852.477.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCGCC AGGCGAAGGA TGACTTCCTG CGGCACTACA CAGTGTCGGA CCCCAGGACT 
CACCCCAAGG GCTACACCGA GTACAAAGTA ACCGCGCAGT TCATCTCAAA GAAGGACCCA 
GAGGATGTCA AAGAGGTGGT GGTCTGGAAG CGGTACAGCG ACTTCCGCAA GCTGCATGGA 
GACCTGGCCT ACACCCACCG CAACCTCTTC CGCCGCCTCG AGGAGTTCCC TGCTTTCCCC 
CGGGCCCAGG TGTTTGGCCG GTTTGAAGCC TCAGTGATCG AGGAGCGGCG AAAGGGGGCA 
GAGGACCTGC TTCGCTTCAC TGTGCACATA CCTGCGCTCA ACAACAGCCC CCAGCTCAAG 
GAGTTCTTCC GGGGTGGGGA GGTGACCCGA CCCTTGGAGG TGTCCAGGGA CCTACACATC 
CTGCCACCCC CTCTGATCCC CACCCCGCCC CCTGATGACC CCCGGCTATC CCAACTGCTC 
CCTGCAGAAA GGAGGGGCCT CGAGGAATTG GAGGTGCCAG TGGACCCCCC ACCATCCAGC 
CCTGCCCAGG AGGCCCTGGA TCTCCTCTTT AACTGTGAGA GCACCGAGGA GGCATCTGGT 
TCCCCTGCCC GAGGCCCCCT CACCGAGGCT GAGCTTGCCC TCTTCGACCC CTTCTCCAAG 
GAAGGTGACC CGTTGCCTGC CCGCCAGGAA GGTGTGAAGA AGAAGGCAGC TGAGTACCTG 
AAGCGGGCAG AGGAGATCCT GCGCCTGCAC CTGTCTCAAC TCCCACCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_680086.2
CDS	131..901
Translation	MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDPPPSSPAQEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEGDPLPARQEGVKKKAAEYLKRAEEILRLHLSQLPP

Target ORF information:

RefSeq Version	NM_147777.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sorting nexin 15 (SNX15), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_147777.3

ORF Insert Sequence:

ATGTCCCGCC AGGCGAAGGA TGACTTCCTG CGGCACTACA CAGTGTCGGA CCCCAGGACT 
CACCCCAAGG GCTACACCGA GTACAAAGTA ACCGCGCAGT TCATCTCAAA GAAGGACCCA 
GAGGATGTCA AAGAGGTGGT GGTCTGGAAG CGGTACAGCG ACTTCCGCAA GCTGCATGGA 
GACCTGGCCT ACACCCACCG CAACCTCTTC CGCCGCCTCG AGGAGTTCCC TGCTTTCCCC 
CGGGCCCAGG TGTTTGGCCG GTTTGAAGCC TCAGTGATCG AGGAGCGGCG AAAGGGGGCA 
GAGGACCTGC TTCGCTTCAC TGTGCACATA CCTGCGCTCA ACAACAGCCC CCAGCTCAAG 
GAGTTCTTCC GGGGTGGGGA GGTGACCCGA CCCTTGGAGG TGTCCAGGGA CCTACACATC 
CTGCCACCCC CTCTGATCCC CACCCCGCCC CCTGATGACC CCCGGCTATC CCAACTGCTC 
CCTGCAGAAA GGAGGGGCCT CGAGGAATTG GAGGTGCCAG TGGACCCCCC ACCATCCAGC 
CCTGCCCAGG AGGCCCTGGA TCTCCTCTTT AACTGTGAGA GCACCGAGGA GGCATCTGGT 
TCCCCTGCCC GAGGCCCCCT CACCGAGGCT GAGCTTGCCC TCTTCGACCC CTTCTCCAAG 
GAAGGTGACC CGTTGCCTGC CCGCCAGGAA GGTGTGAAGA AGAAGGCAGC TGAGTACCTG 
AAGCGGGCAG AGGAGATCCT GCGCCTGCAC CTGTCTCAAC TCCCACCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNX15 ( NM_147777.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_680086.2 Homo sapiens sorting nexin 15 (SNX15), transcript variant B, mRNA.

Price & Availability↑

CloneID	OHu06659
Clone ID Related Accession (Same CDS sequence)	NM_147777.3 , NM_147777.4
Accession Version	NM_147777.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	sorting nexin-15 isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000436.5 and AP003068.3. On May 31, 2019 this sequence version replaced NM_147777.3. Transcript Variant: This variant (B, also known as SNX15A) lacks an alternate in-frame exon in the 3' coding region, compared to variant A, resulting in an isoform (B) that is shorter than isoform A. ##Evidence-Data-START## Transcript exon combination :: ERR279852.477.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCGCC AGGCGAAGGA TGACTTCCTG CGGCACTACA CAGTGTCGGA CCCCAGGACT 
CACCCCAAGG GCTACACCGA GTACAAAGTA ACCGCGCAGT TCATCTCAAA GAAGGACCCA 
GAGGATGTCA AAGAGGTGGT GGTCTGGAAG CGGTACAGCG ACTTCCGCAA GCTGCATGGA 
GACCTGGCCT ACACCCACCG CAACCTCTTC CGCCGCCTCG AGGAGTTCCC TGCTTTCCCC 
CGGGCCCAGG TGTTTGGCCG GTTTGAAGCC TCAGTGATCG AGGAGCGGCG AAAGGGGGCA 
GAGGACCTGC TTCGCTTCAC TGTGCACATA CCTGCGCTCA ACAACAGCCC CCAGCTCAAG 
GAGTTCTTCC GGGGTGGGGA GGTGACCCGA CCCTTGGAGG TGTCCAGGGA CCTACACATC 
CTGCCACCCC CTCTGATCCC CACCCCGCCC CCTGATGACC CCCGGCTATC CCAACTGCTC 
CCTGCAGAAA GGAGGGGCCT CGAGGAATTG GAGGTGCCAG TGGACCCCCC ACCATCCAGC 
CCTGCCCAGG AGGCCCTGGA TCTCCTCTTT AACTGTGAGA GCACCGAGGA GGCATCTGGT 
TCCCCTGCCC GAGGCCCCCT CACCGAGGCT GAGCTTGCCC TCTTCGACCC CTTCTCCAAG 
GAAGGTGACC CGTTGCCTGC CCGCCAGGAA GGTGTGAAGA AGAAGGCAGC TGAGTACCTG 
AAGCGGGCAG AGGAGATCCT GCGCCTGCAC CTGTCTCAAC TCCCACCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_680086.2
CDS	100..870
Translation	MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLKEFFRGGEVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDPPPSSPAQEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEGDPLPARQEGVKKKAAEYLKRAEEILRLHLSQLPP

Target ORF information:

RefSeq Version	NM_147777.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sorting nexin 15 (SNX15), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_147777.4

ORF Insert Sequence:

ATGTCCCGCC AGGCGAAGGA TGACTTCCTG CGGCACTACA CAGTGTCGGA CCCCAGGACT 
CACCCCAAGG GCTACACCGA GTACAAAGTA ACCGCGCAGT TCATCTCAAA GAAGGACCCA 
GAGGATGTCA AAGAGGTGGT GGTCTGGAAG CGGTACAGCG ACTTCCGCAA GCTGCATGGA 
GACCTGGCCT ACACCCACCG CAACCTCTTC CGCCGCCTCG AGGAGTTCCC TGCTTTCCCC 
CGGGCCCAGG TGTTTGGCCG GTTTGAAGCC TCAGTGATCG AGGAGCGGCG AAAGGGGGCA 
GAGGACCTGC TTCGCTTCAC TGTGCACATA CCTGCGCTCA ACAACAGCCC CCAGCTCAAG 
GAGTTCTTCC GGGGTGGGGA GGTGACCCGA CCCTTGGAGG TGTCCAGGGA CCTACACATC 
CTGCCACCCC CTCTGATCCC CACCCCGCCC CCTGATGACC CCCGGCTATC CCAACTGCTC 
CCTGCAGAAA GGAGGGGCCT CGAGGAATTG GAGGTGCCAG TGGACCCCCC ACCATCCAGC 
CCTGCCCAGG AGGCCCTGGA TCTCCTCTTT AACTGTGAGA GCACCGAGGA GGCATCTGGT 
TCCCCTGCCC GAGGCCCCCT CACCGAGGCT GAGCTTGCCC TCTTCGACCC CTTCTCCAAG 
GAAGGTGACC CGTTGCCTGC CCGCCAGGAA GGTGTGAAGA AGAAGGCAGC TGAGTACCTG 
AAGCGGGCAG AGGAGATCCT GCGCCTGCAC CTGTCTCAAC TCCCACCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SNX15 Regulates Cell Surface Recycling of APP and A? Generation.
Molecular neurobiology53(6)3690-3701(2016 Aug)
Feng T,Niu M,Ji C,Gao Y,Wen J,Bu G,Xu H,Zhang YW

SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome.
Journal of cell science126(Pt 21)4885-99(2013 Nov)
Danson C,Brown E,Hemmings OJ,McGough IJ,Yarwood S,Heesom KJ,Carlton JG,Martin-Serrano J,May MT,Verkade P,Cullen PJ

Next-generation sequencing to generate interactome datasets.
Nature methods8(6)478-80(2011 Jun)
Yu H,Tardivo L,Tam S,Weiner E,Gebreab F,Fan C,Svrzikapa N,Hirozane-Kishikawa T,Rietman E,Yang X,Sahalie J,Salehi-Ashtiani K,Hao T,Cusick ME,Hill DE,Roth FP,Braun P,Vidal M

Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.
Nucleic acids research39(1)44-58(2011 Jan)
Wang W,Shen P,Thiyagarajan S,Lin S,Palm C,Horvath R,Klopstock T,Cutler D,Pique L,Schrijver I,Davis RW,Mindrinos M,Speed TP,Scharfe C

A clinical, genetic and candidate gene study of Silver syndrome, a complicated form of hereditary spastic paraplegia.
Journal of neurology251(9)1068-74(2004 Sep)
Warner TT,Patel H,Proukakis C,Reed JA,McKie L,Wills A,Patton MA,Crosby AH

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SNX15 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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