PSMC3IP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSMC3IP
Entrez Gene ID	29893
Full Name	PSMC3 interacting protein
Synonyms	GT198,HOP2,HUMGT198A,ODG3,TBPIP
General protein information	Preferred Names PSMC3 interacting protein Names homologous-pairing protein 2 homolog DBD-interacting TBP-1-interacting protein nuclear receptor coactivator GT198 proteasome 26S ATPase subunit 3-interacting protein tat-binding protein 1-interacting protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.2
Summary	This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011].
Disorder MIM:	608665
Disorder Html:	Ovarian dysgenesis 3, 614324 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256016.1	NP_001242945.1	homologous-pairing protein 2 homolog isoform 4
NM_013290.6	NP_037422.2	homologous-pairing protein 2 homolog isoform 1
NM_016556.4	NP_057640.1	homologous-pairing protein 2 homolog isoform 2
NM_001256015.1	NP_001242944.1	homologous-pairing protein 2 homolog isoform 4
NM_001256014.1	NP_001242943.1	homologous-pairing protein 2 homolog isoform 3
NM_016556.3	NP_057640.1	homologous-pairing protein 2 homolog isoform 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC789362	XP_005220859.1
Mus musculus (house mouse)	Psmc3ip	NP_032975.1
Homo sapiens (human)	PSMC3IP	NP_057640.1
	LOC710658	XP_002808173.1
Rattus norvegicus (Norway rat)	Psmc3ip	NP_604453.2
Xenopus tropicalis (tropical clawed frog)	psmc3ip	NP_001124002.1
Pan troglodytes (chimpanzee)	PSMC3IP	XP_001164255.1
Arabidopsis thaliana (thale cress)	AHP2	NP_172791.1
Canis lupus familiaris (dog)	PSMC3IP	XP_005624503.1
Danio rerio (zebrafish)	psmc3ip	NP_001002124.1

Gene Ontology
Bibliography

Related articles in PubMed

Primary Ovarian Insufficiency and Azospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation.
Al-Agha AE, Ahmed IA, Nuebel E, Moriwaki M, Moore B, Peacock KA, Mosbruger T, Neklason DW, Jorde LB, Yandell M, Welt CK
The Journal of clinical endocrinology and metabolism(2017 Dec)

No mutations in the PSMC3IP gene identified in a Swedish cohort of women with primary ovarian insufficiency.
Norling A, Hirschberg AL, Karlsson L, Rodriguez-Wallberg KA, Iwarsson E, Wedell A, Barbaro M
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation8(4)146-50(2014)

Human ovarian cancer stroma contains luteinized theca cells harboring tumor suppressor gene GT198 mutations.
Peng M, Zhang H, Jaafar L, Risinger JI, Huang S, Mivechi NF, Ko L
The Journal of biological chemistry288(46)33387-97(2013 Nov)

XX ovarian dysgenesis is caused by a PSMC3IP/HOP2 mutation that abolishes coactivation of estrogen-driven transcription.
Zangen D, Kaufman Y, Zeligson S, Perlberg S, Fridman H, Kanaan M, Abdulhadi-Atwan M, Abu Libdeh A, Gussow A, Kisslov I, Carmel L, Renbaum P, Levy-Lahad E
American journal of human genetics89(4)572-9(2011 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PSMC3IP gene mutations are not common causes of primary ovarian insufficiency in this Swedish cohort.
Title: No mutations in the PSMC3IP gene identified in a Swedish cohort of women with primary ovarian insufficiency.

GT198 mutant luteinized theca cells overexpressing CYP17 are common in ovarian cancer stroma.
Title: Human ovarian cancer stroma contains luteinized theca cells harboring tumor suppressor gene GT198 mutations.

a PSMC3IP/HOP2 mutation may cause XX ovarian dysgenesis through abolishing coactivation of estrogen-driven transcription
Title: XX ovarian dysgenesis is caused by a PSMC3IP/HOP2 mutation that abolishes coactivation of estrogen-driven transcription.

findings suggest that a component of 19S regulatory particles directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with TBPIP.
Title: Tat-binding protein-1 (TBP-1), an ATPase of 19S regulatory particles of the 26S proteasome, enhances androgen receptor function in cooperation with TBP-1-interacting protein/Hop2.

Observational study of gene-disease association. (HuGE Navigator)
Title: Two single nucleotide polymorphisms in PRDM9 (MEISETZ) gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.

The following PSMC3IP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSMC3IP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02316	NM_016556.4 Latest version!	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu02629	NM_001256014.1 Latest version!	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu02631	NM_001256015.1 Latest version!	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu02631	NM_001256016.1 Latest version!	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu06492	NM_013290.6 Latest version!	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu02316	NM_016556.3	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSMC3IP ( NM_016556.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057640.1 Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02316
Clone ID Related Accession (Same CDS sequence)	NM_016556.4 , NM_016556.3
Accession Version	NM_016556.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	homologous-pairing protein 2 homolog isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC067852.23. On Aug 2, 2019 this sequence version replaced NM_016556.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.513201.1, AB030304.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTAAAG GCCGGGCAGA AGCTGCGGCG GGAGCCGCCG GGATCCTCCT GAGGTACCTG 
CAGGAGCAGA ACCGGCCCTA CAGCTCCCAG GATGTGTTCG GGAACCTACA GCGGGAACAC 
GGACTGGGCA AGGCGGTGGT GGTGAAGACG CTGGAGCAGC TGGCGCAACA AGGCAAGATC 
AAAGAGAAGA TGTACGGCAA GCAGAAGATC TATTTTGCGG ATCAGGACCA GTTTGACATG 
GTGAGTGATG CTGACCTTCA AGTCCTAGAT GGCAAAATCG TGGCCCTCAC TGCTAAGGTG 
CAGAGCTTGC AGCAGAGCTG CCGCTACATG GAGGCTGAGC TCAAGGAATT ATCTAGTGCC 
CTGACCACAC CAGAGATGCA GAAAGAAATC CAGGAGTTAA AGAAGGAATG CGCTGGCTAC 
AGAGAGAGAT TGAAGAACAT TAAAGCAGCT ACCAATCATG TGACTCCAGA AGAGAAAGAG 
CAGGTGTACA GAGAGAGGCA GAAGTACTGT AAGGAGTGGA GGAAGAGGAA GAGGATGGCT 
ACAGAGCTGT CTGATGCAAT ACTTGAAGGA TACCCCAAGA GCAAGAAGCA GTTCTTTGAG 
GAAGTTGGGA TAGAGACGGA TGAAGATTAC AACGTCACAC TCCCAGACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057640.1
CDS	44..697
Translation	MSKGRAEAAAGAAGILLRYLQEQNRPYSSQDVFGNLQREHGLGKAVVVKTLEQLAQQGKIKEKMYGKQKIYFADQDQFDMVSDADLQVLDGKIVALTAKVQSLQQSCRYMEAELKELSSALTTPEMQKEIQELKKECAGYRERLKNIKAATNHVTPEEKEQVYRERQKYCKEWRKRKRMATELSDAILEGYPKSKKQFFEEVGIETDEDYNVTLPDP

Target ORF information:

RefSeq Version	NM_016556.4
Organism	Homo sapiens(human)
Definition	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016556.4

ORF Insert Sequence:

ATGAGTAAAG GCCGGGCAGA AGCTGCGGCG GGAGCCGCCG GGATCCTCCT GAGGTACCTG 
CAGGAGCAGA ACCGGCCCTA CAGCTCCCAG GATGTGTTCG GGAACCTACA GCGGGAACAC 
GGACTGGGCA AGGCGGTGGT GGTGAAGACG CTGGAGCAGC TGGCGCAACA AGGCAAGATC 
AAAGAGAAGA TGTACGGCAA GCAGAAGATC TATTTTGCGG ATCAGGACCA GTTTGACATG 
GTGAGTGATG CTGACCTTCA AGTCCTAGAT GGCAAAATCG TGGCCCTCAC TGCTAAGGTG 
CAGAGCTTGC AGCAGAGCTG CCGCTACATG GAGGCTGAGC TCAAGGAATT ATCTAGTGCC 
CTGACCACAC CAGAGATGCA GAAAGAAATC CAGGAGTTAA AGAAGGAATG CGCTGGCTAC 
AGAGAGAGAT TGAAGAACAT TAAAGCAGCT ACCAATCATG TGACTCCAGA AGAGAAAGAG 
CAGGTGTACA GAGAGAGGCA GAAGTACTGT AAGGAGTGGA GGAAGAGGAA GAGGATGGCT 
ACAGAGCTGT CTGATGCAAT ACTTGAAGGA TACCCCAAGA GCAAGAAGCA GTTCTTTGAG 
GAAGTTGGGA TAGAGACGGA TGAAGATTAC AACGTCACAC TCCCAGACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMC3IP ( NM_016556.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057640.1 Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02316
Clone ID Related Accession (Same CDS sequence)	NM_016556.4 , NM_016556.3
Accession Version	NM_016556.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	homologous-pairing protein 2 homolog isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008792.1, FJ952179.1 and BQ186038.1. On Dec 21, 2011 this sequence version replaced NM_016556.2. Transcript Variant: This variant (2) encodes the longest isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.513201.1, SRR1660803.226238.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2161674 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTAAAG GCCGGGCAGA AGCTGCGGCG GGAGCCGCCG GGATCCTCCT GAGGTACCTG 
CAGGAGCAGA ACCGGCCCTA CAGCTCCCAG GATGTGTTCG GGAACCTACA GCGGGAACAC 
GGACTGGGCA AGGCGGTGGT GGTGAAGACG CTGGAGCAGC TGGCGCAACA AGGCAAGATC 
AAAGAGAAGA TGTACGGCAA GCAGAAGATC TATTTTGCGG ATCAGGACCA GTTTGACATG 
GTGAGTGATG CTGACCTTCA AGTCCTAGAT GGCAAAATCG TGGCCCTCAC TGCTAAGGTG 
CAGAGCTTGC AGCAGAGCTG CCGCTACATG GAGGCTGAGC TCAAGGAATT ATCTAGTGCC 
CTGACCACAC CAGAGATGCA GAAAGAAATC CAGGAGTTAA AGAAGGAATG CGCTGGCTAC 
AGAGAGAGAT TGAAGAACAT TAAAGCAGCT ACCAATCATG TGACTCCAGA AGAGAAAGAG 
CAGGTGTACA GAGAGAGGCA GAAGTACTGT AAGGAGTGGA GGAAGAGGAA GAGGATGGCT 
ACAGAGCTGT CTGATGCAAT ACTTGAAGGA TACCCCAAGA GCAAGAAGCA GTTCTTTGAG 
GAAGTTGGGA TAGAGACGGA TGAAGATTAC AACGTCACAC TCCCAGACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057640.1
CDS	146..799
Translation	MSKGRAEAAAGAAGILLRYLQEQNRPYSSQDVFGNLQREHGLGKAVVVKTLEQLAQQGKIKEKMYGKQKIYFADQDQFDMVSDADLQVLDGKIVALTAKVQSLQQSCRYMEAELKELSSALTTPEMQKEIQELKKECAGYRERLKNIKAATNHVTPEEKEQVYRERQKYCKEWRKRKRMATELSDAILEGYPKSKKQFFEEVGIETDEDYNVTLPDP

Target ORF information:

RefSeq Version	NM_016556.3
Organism	Homo sapiens(human)
Definition	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016556.3

ORF Insert Sequence:

ATGAGTAAAG GCCGGGCAGA AGCTGCGGCG GGAGCCGCCG GGATCCTCCT GAGGTACCTG 
CAGGAGCAGA ACCGGCCCTA CAGCTCCCAG GATGTGTTCG GGAACCTACA GCGGGAACAC 
GGACTGGGCA AGGCGGTGGT GGTGAAGACG CTGGAGCAGC TGGCGCAACA AGGCAAGATC 
AAAGAGAAGA TGTACGGCAA GCAGAAGATC TATTTTGCGG ATCAGGACCA GTTTGACATG 
GTGAGTGATG CTGACCTTCA AGTCCTAGAT GGCAAAATCG TGGCCCTCAC TGCTAAGGTG 
CAGAGCTTGC AGCAGAGCTG CCGCTACATG GAGGCTGAGC TCAAGGAATT ATCTAGTGCC 
CTGACCACAC CAGAGATGCA GAAAGAAATC CAGGAGTTAA AGAAGGAATG CGCTGGCTAC 
AGAGAGAGAT TGAAGAACAT TAAAGCAGCT ACCAATCATG TGACTCCAGA AGAGAAAGAG 
CAGGTGTACA GAGAGAGGCA GAAGTACTGT AAGGAGTGGA GGAAGAGGAA GAGGATGGCT 
ACAGAGCTGT CTGATGCAAT ACTTGAAGGA TACCCCAAGA GCAAGAAGCA GTTCTTTGAG 
GAAGTTGGGA TAGAGACGGA TGAAGATTAC AACGTCACAC TCCCAGACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMC3IP ( NM_001256014.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001242943.1 Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu02629
Clone ID Related Accession (Same CDS sequence)	NM_001256014.1
Accession Version	NM_001256014.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	homologous-pairing protein 2 homolog isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB494067.1, GQ851964.1, BC008792.1 and BQ186038.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.520388.1, SRR1803611.366430.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119, SAMEA2161674 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTACGGCA AGCAGAAGAT CTATTTTGCG GATCAGGACC AGTTTGACAT GGTGAGTGAT 
GCTGACCTTC AAGTCCTAGA TGGCAAAATC GTGGCCCTCA CTGCTAAGGT GCAGAGCTTG 
CAGCAGAGCT GCCGCTACAT GGAGGCTGAG CTCAAGGAAT TATCTAGTGC CCTGACCACA 
CCAGAGATGC AGAAAGAAAT CCAGGAGTTA AAGAAGGAAT GCGCTGGCTA CAGAGAGAGA 
TTGAAGAACA TTAAAGCAGC TACCAATCAT GTGACTCCAG AAGAGAAAGA GCAGGTGTAC 
AGAGAGAGGC AGAAGTACTG TAAGGAGTGG AGGAAGAGGA AGAGGATGGC TACAGAGCTG 
TCTGATGCAA TACTTGAAGG ATACCCCAAG AGCAAGAAGC AGTTCTTTGA GGAAGTTGGG 
ATAGAGACGG ATGAAGATTA CAACGTCACA CTCCCAGACC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001242943.1
CDS	311..775
Translation	MYGKQKIYFADQDQFDMVSDADLQVLDGKIVALTAKVQSLQQSCRYMEAELKELSSALTTPEMQKEIQELKKECAGYRERLKNIKAATNHVTPEEKEQVYRERQKYCKEWRKRKRMATELSDAILEGYPKSKKQFFEEVGIETDEDYNVTLPDP

Target ORF information:

RefSeq Version	NM_001256014.1
Organism	Homo sapiens(human)
Definition	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256014.1

ORF Insert Sequence:

ATGTACGGCA AGCAGAAGAT CTATTTTGCG GATCAGGACC AGTTTGACAT GGTGAGTGAT 
GCTGACCTTC AAGTCCTAGA TGGCAAAATC GTGGCCCTCA CTGCTAAGGT GCAGAGCTTG 
CAGCAGAGCT GCCGCTACAT GGAGGCTGAG CTCAAGGAAT TATCTAGTGC CCTGACCACA 
CCAGAGATGC AGAAAGAAAT CCAGGAGTTA AAGAAGGAAT GCGCTGGCTA CAGAGAGAGA 
TTGAAGAACA TTAAAGCAGC TACCAATCAT GTGACTCCAG AAGAGAAAGA GCAGGTGTAC 
AGAGAGAGGC AGAAGTACTG TAAGGAGTGG AGGAAGAGGA AGAGGATGGC TACAGAGCTG 
TCTGATGCAA TACTTGAAGG ATACCCCAAG AGCAAGAAGC AGTTCTTTGA GGAAGTTGGG 
ATAGAGACGG ATGAAGATTA CAACGTCACA CTCCCAGACC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMC3IP ( NM_001256016.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001242945.1 Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu02631
Clone ID Related Accession (Same CDS sequence)	NM_001256016.1 , NM_001256015.1
Accession Version	NM_001256016.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	homologous-pairing protein 2 homolog isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008792.1, BI115923.1 and BQ186038.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI115923.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2151119, SAMEA2161674 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGAGTG ATGCTGACCT TCAAGTCCTA GATGGCAAAA TCGTGGCCCT CACTGCTAAG 
GTGCAGAGCT TGCAGCAGAG CTGCCGCTAC ATGGAGGCTG AGCTCAAGGA ATTATCTAGT 
GCCCTGACCA CACCAGAGAT GCAGAAAGAA ATCCAGGAGT TAAAGAAGGA ATGCGCTGGC 
TACAGAGAGA GATTGAAGAA CATTAAAGCA GCTACCAATC ATGTGACTCC AGAAGAGAAA 
GAGCAGGTGT ACAGAGAGAG GCAGAAGTAC TGTAAGGAGT GGAGGAAGAG GAAGAGGATG 
GCTACAGAGC TGTCTGATGC AATACTTGAA GGATACCCCA AGAGCAAGAA GCAGTTCTTT 
GAGGAAGTTG GGATAGAGAC GGATGAAGAT TACAACGTCA CACTCCCAGA CCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001242945.1
CDS	402..818
Translation	MVSDADLQVLDGKIVALTAKVQSLQQSCRYMEAELKELSSALTTPEMQKEIQELKKECAGYRERLKNIKAATNHVTPEEKEQVYRERQKYCKEWRKRKRMATELSDAILEGYPKSKKQFFEEVGIETDEDYNVTLPDP

Target ORF information:

RefSeq Version	NM_001256016.1
Organism	Homo sapiens(human)
Definition	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256016.1

ORF Insert Sequence:

ATGGTGAGTG ATGCTGACCT TCAAGTCCTA GATGGCAAAA TCGTGGCCCT CACTGCTAAG 
GTGCAGAGCT TGCAGCAGAG CTGCCGCTAC ATGGAGGCTG AGCTCAAGGA ATTATCTAGT 
GCCCTGACCA CACCAGAGAT GCAGAAAGAA ATCCAGGAGT TAAAGAAGGA ATGCGCTGGC 
TACAGAGAGA GATTGAAGAA CATTAAAGCA GCTACCAATC ATGTGACTCC AGAAGAGAAA 
GAGCAGGTGT ACAGAGAGAG GCAGAAGTAC TGTAAGGAGT GGAGGAAGAG GAAGAGGATG 
GCTACAGAGC TGTCTGATGC AATACTTGAA GGATACCCCA AGAGCAAGAA GCAGTTCTTT 
GAGGAAGTTG GGATAGAGAC GGATGAAGAT TACAACGTCA CACTCCCAGA CCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMC3IP ( NM_001256015.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001242944.1 Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu02631
Clone ID Related Accession (Same CDS sequence)	NM_001256016.1 , NM_001256015.1
Accession Version	NM_001256015.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	homologous-pairing protein 2 homolog isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008792.1, FJ952182.1 and BQ186038.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FJ952182.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGAGTG ATGCTGACCT TCAAGTCCTA GATGGCAAAA TCGTGGCCCT CACTGCTAAG 
GTGCAGAGCT TGCAGCAGAG CTGCCGCTAC ATGGAGGCTG AGCTCAAGGA ATTATCTAGT 
GCCCTGACCA CACCAGAGAT GCAGAAAGAA ATCCAGGAGT TAAAGAAGGA ATGCGCTGGC 
TACAGAGAGA GATTGAAGAA CATTAAAGCA GCTACCAATC ATGTGACTCC AGAAGAGAAA 
GAGCAGGTGT ACAGAGAGAG GCAGAAGTAC TGTAAGGAGT GGAGGAAGAG GAAGAGGATG 
GCTACAGAGC TGTCTGATGC AATACTTGAA GGATACCCCA AGAGCAAGAA GCAGTTCTTT 
GAGGAAGTTG GGATAGAGAC GGATGAAGAT TACAACGTCA CACTCCCAGA CCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001242944.1
CDS	516..932
Translation	MVSDADLQVLDGKIVALTAKVQSLQQSCRYMEAELKELSSALTTPEMQKEIQELKKECAGYRERLKNIKAATNHVTPEEKEQVYRERQKYCKEWRKRKRMATELSDAILEGYPKSKKQFFEEVGIETDEDYNVTLPDP

Target ORF information:

RefSeq Version	NM_001256015.1
Organism	Homo sapiens(human)
Definition	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256015.1

ORF Insert Sequence:

ATGGTGAGTG ATGCTGACCT TCAAGTCCTA GATGGCAAAA TCGTGGCCCT CACTGCTAAG 
GTGCAGAGCT TGCAGCAGAG CTGCCGCTAC ATGGAGGCTG AGCTCAAGGA ATTATCTAGT 
GCCCTGACCA CACCAGAGAT GCAGAAAGAA ATCCAGGAGT TAAAGAAGGA ATGCGCTGGC 
TACAGAGAGA GATTGAAGAA CATTAAAGCA GCTACCAATC ATGTGACTCC AGAAGAGAAA 
GAGCAGGTGT ACAGAGAGAG GCAGAAGTAC TGTAAGGAGT GGAGGAAGAG GAAGAGGATG 
GCTACAGAGC TGTCTGATGC AATACTTGAA GGATACCCCA AGAGCAAGAA GCAGTTCTTT 
GAGGAAGTTG GGATAGAGAC GGATGAAGAT TACAACGTCA CACTCCCAGA CCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMC3IP ( NM_013290.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_037422.2 Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 1, mRNA.

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CloneID	OHu06492
Clone ID Related Accession (Same CDS sequence)	NM_013290.6
Accession Version	NM_013290.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	homologous-pairing protein 2 homolog isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008792.1 and BQ186038.1. On Dec 22, 2011 this sequence version replaced NM_013290.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008792.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2161674 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTAAAG GCCGGGCAGA AGCTGCGGCG GGAGCCGCCG GGATCCTCCT GAGGTACCTG 
CAGGAGCAGA ACCGGCCCTA CAGCTCCCAG GATGTGTTCG GGAACCTACA GCGGGAACAC 
GGACTGGGCA AGGCGGTGGT GGTGAAGACG CTGGAGCAGC TGGCGCAACA AGGCAAGATC 
AAAGAGAAGA TGTACGGCAA GCAGAAGATC TATTTTGCGG ATCAGGACCA GTTTGACATG 
GTGAGTGATG CTGACCTTCA AGTCCTAGAT GGCAAAATCG TGGCCCTCAC TGCTAAGGTG 
CAGAGCTTGC AGCAGAGCTG CCGCTACATG GAGGCTGAGA TGCAGAAAGA AATCCAGGAG 
TTAAAGAAGG AATGCGCTGG CTACAGAGAG AGATTGAAGA ACATTAAAGC AGCTACCAAT 
CATGTGACTC CAGAAGAGAA AGAGCAGGTG TACAGAGAGA GGCAGAAGTA CTGTAAGGAG 
TGGAGGAAGA GGAAGAGGAT GGCTACAGAG CTGTCTGATG CAATACTTGA AGGATACCCC 
AAGAGCAAGA AGCAGTTCTT TGAGGAAGTT GGGATAGAGA CGGATGAAGA TTACAACGTC 
ACACTCCCAG ACCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037422.2
CDS	146..763
Translation	MSKGRAEAAAGAAGILLRYLQEQNRPYSSQDVFGNLQREHGLGKAVVVKTLEQLAQQGKIKEKMYGKQKIYFADQDQFDMVSDADLQVLDGKIVALTAKVQSLQQSCRYMEAEMQKEIQELKKECAGYRERLKNIKAATNHVTPEEKEQVYRERQKYCKEWRKRKRMATELSDAILEGYPKSKKQFFEEVGIETDEDYNVTLPDP

Target ORF information:

RefSeq Version	NM_013290.6
Organism	Homo sapiens(human)
Definition	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013290.6

ORF Insert Sequence:

ATGAGTAAAG GCCGGGCAGA AGCTGCGGCG GGAGCCGCCG GGATCCTCCT GAGGTACCTG 
CAGGAGCAGA ACCGGCCCTA CAGCTCCCAG GATGTGTTCG GGAACCTACA GCGGGAACAC 
GGACTGGGCA AGGCGGTGGT GGTGAAGACG CTGGAGCAGC TGGCGCAACA AGGCAAGATC 
AAAGAGAAGA TGTACGGCAA GCAGAAGATC TATTTTGCGG ATCAGGACCA GTTTGACATG 
GTGAGTGATG CTGACCTTCA AGTCCTAGAT GGCAAAATCG TGGCCCTCAC TGCTAAGGTG 
CAGAGCTTGC AGCAGAGCTG CCGCTACATG GAGGCTGAGA TGCAGAAAGA AATCCAGGAG 
TTAAAGAAGG AATGCGCTGG CTACAGAGAG AGATTGAAGA ACATTAAAGC AGCTACCAAT 
CATGTGACTC CAGAAGAGAA AGAGCAGGTG TACAGAGAGA GGCAGAAGTA CTGTAAGGAG 
TGGAGGAAGA GGAAGAGGAT GGCTACAGAG CTGTCTGATG CAATACTTGA AGGATACCCC 
AAGAGCAAGA AGCAGTTCTT TGAGGAAGTT GGGATAGAGA CGGATGAAGA TTACAACGTC 
ACACTCCCAG ACCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Primary Ovarian Insufficiency and Azospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation.
The Journal of clinical endocrinology and metabolism(2017 Dec)
Al-Agha AE,Ahmed IA,Nuebel E,Moriwaki M,Moore B,Peacock KA,Mosbruger T,Neklason DW,Jorde LB,Yandell M,Welt CK

No mutations in the PSMC3IP gene identified in a Swedish cohort of women with primary ovarian insufficiency.
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation8(4)146-50(2014)
Norling A,Hirschberg AL,Karlsson L,Rodriguez-Wallberg KA,Iwarsson E,Wedell A,Barbaro M

Human ovarian cancer stroma contains luteinized theca cells harboring tumor suppressor gene GT198 mutations.
The Journal of biological chemistry288(46)33387-97(2013 Nov)
Peng M,Zhang H,Jaafar L,Risinger JI,Huang S,Mivechi NF,Ko L

XX ovarian dysgenesis is caused by a PSMC3IP/HOP2 mutation that abolishes coactivation of estrogen-driven transcription.
American journal of human genetics89(4)572-9(2011 Oct)
Zangen D,Kaufman Y,Zeligson S,Perlberg S,Fridman H,Kanaan M,Abdulhadi-Atwan M,Abu Libdeh A,Gussow A,Kisslov I,Carmel L,Renbaum P,Levy-Lahad E

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PSMC3IP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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