ANAPC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ANAPC2
Entrez Gene ID	29882
Full Name	anaphase promoting complex subunit 2
Synonyms	APC2
General protein information	Preferred Names anaphase promoting complex subunit 2 Names anaphase-promoting complex subunit 2 cyclosome subunit 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q34.3
Summary	A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008].
Disorder MIM:	606946

mRNA and Protein(s)

mRNA	Protein	Name
NM_013366.4	NP_037498.1	anaphase-promoting complex subunit 2
NM_013366.3	NP_037498.1	anaphase-promoting complex subunit 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Anapc2	NP_001094002.1
Gallus gallus (chicken)	ANAPC2	XP_415533.2
Arabidopsis thaliana (thale cress)	APC2	NP_178543.2
Pan troglodytes (chimpanzee)	ANAPC2	XP_520643.3
	ANAPC2	XP_001090195.1
Canis lupus familiaris (dog)	ANAPC2	XP_548357.2
Danio rerio (zebrafish)	anapc2	NP_001243675.1
Homo sapiens (human)	ANAPC2	NP_037498.1
Mus musculus (house mouse)	Anapc2	NP_780509.2
Drosophila melanogaster (fruit fly)	mr	NP_611862.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005048	XP_313920.4
Oryza sativa (rice)	Os04g0484800	NP_001053127.2
Xenopus tropicalis (tropical clawed frog)	anapc2	XP_004917614.1

Gene Ontology
Bibliography

Related articles in PubMed

The expression pattern of APC2 and APC7 in various cancer cell lines and AML patients.
Rahimi H, Ahmadzadeh A, Yousef-amoli S, Kokabee L, Shokrgozar MA, Mahdian R, Karimipoor M
Advances in medical sciences60(2)259-63(2015 Sep)

Atomic structure of the APC/C and its mechanism of protein ubiquitination.
Chang L, Zhang Z, Yang J, McLaughlin SH, Barford D
Nature522(7557)450-454(2015 Jun)

SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.
van der Lelij P, Stocsits RR, Ladurner R, Petzold G, Kreidl E, Koch B, Schmitz J, Neumann B, Ellenberg J, Peters JM
The EMBO journal33(22)2643-58(2014 Nov)

The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2.
He Y, Tollini L, Kim TH, Itahana Y, Zhang Y
Cell cycle (Georgetown, Tex.)13(13)2101-9(2014)

Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex.
Wang W, Kirschner MW
Nature cell biology15(7)797-806(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results showed that APC2 and APC7 subunits were both over expressed in cancer cell lines
Title: The expression pattern of APC2 and APC7 in various cancer cell lines and AML patients.

A transcriptome-wide analysis revealed that SNW1 or PRPF8 depletion affects the splicing of specific introns in a subset of pre-mRNAs, including pre-mRNAs encoding the cohesion protein sororin and the APC/C subunit APC2.
Title: SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.

The regulation of Mdm2 by the E3 ubiquitin ligase APC/C is shown. It has important therapeutic implications for tumors with Mdm2 overexpression.
Title: The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2.

anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonists are novel regulators of cell growth and apoptosis
Title: Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.

It proposes a role for APC/C(Cdh1) in modulating the status of PCNA monoubiquitination and UV DNA repair before S phase entry.
Title: APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.

The following ANAPC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ANAPC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13061	NM_013366.4 Latest version!	Homo sapiens anaphase promoting complex subunit 2 (ANAPC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu13061	NM_013366.3	Homo sapiens anaphase promoting complex subunit 2 (ANAPC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ANAPC2 ( NM_013366.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037498.1 Homo sapiens anaphase promoting complex subunit 2 (ANAPC2), mRNA.

Price & Availability↑

CloneID	OHu13061
Clone ID Related Accession (Same CDS sequence)	NM_013366.4 , NM_013366.3
Accession Version	NM_013366.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2469bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	anaphase-promoting complex subunit 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM925063.1 and BC032503.1. On Nov 22, 2018 this sequence version replaced NM_013366.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.140686.1, SRR1163658.239610.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000323927.3/ ENSP00000314004.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGG CAGTTGTGGT GGCGGAGGGG GACAGCGACT CCCGGCCCGG ACAGGAGTTG 
TTAGTGGCCT GGAACACCGT GAGCACCGGC CTGGTGCCGC CGGCTGCGCT GGGGCTGGTG 
TCTTCCCGGA CCAGCGGTGC AGTCCCGCCA AAGGAAGAGG AGCTCCGGGC GGCGGTGGAG 
GTTCTGAGGG GCCACGGGCT ACACTCGGTC CTGGAGGAGT GGTTCGTGGA GGTGCTGCAG 
AACGATCTGC AGGCCAACAT CTCCCCTGAG TTCTGGAATG CCATCTCCCA ATGCGAGAAC 
TCTGCGGATG AGCCCCAGTG CCTTTTGCTA CTCCTTGACG CTTTTGGCCT GCTGGAGAGC 
CGCCTGGATC CCTACCTGCG TAGCCTAGAG CTGCTGGAGA AATGGACTCG CCTGGGCTTG 
CTGATGGGCA CTGGTGCTCA GGGGCTGCGA GAAGAAGTCC ACACTATGTT GCGCGGAGTC 
TTGTTCTTTA GCACCCCCAG AACCTTCCAA GAGATGATCC AGCGTCTGTA TGGGTGCTTC 
TTGAGAGTCT ATATGCAGAG TAAGAGGAAG GGGGAAGGGG GCACAGACCC GGAACTGGAA 
GGGGAGCTGG ACAGCCGGTA TGCCCGTCGC CGGTACTACC GGCTCCTGCA GAGCCCGCTG 
TGTGCAGGGT GCAGCAGTGA CAAGCAACAG TGCTGGTGTC GCCAGGCTCT GGAGCAGTTC 
CATCAGCTCA GCCAGGTCTT ACACAGGCTC AGTCTGCTGG AGCGGGTCAG TGCCGAGGCT 
GTGACCACCA CCCTGCACCA GGTGACCCGG GAGAGGATGG AGGACCGTTG CCGGGGCGAG 
TACGAGCGCT CCTTCCTGCG TGAGTTCCAC AAGTGGATCG AGCGGGTGGT CGGCTGGCTC 
GGCAAGGTGT TCCTGCAGGA CGGCCCCGCC AGGCCCGCAT CTCCCGAGGC CGGCAACACC 
CTGCGCCGCT GGCGCTGCCA CGTGCAAAGG TTCTTCTACC GCATCTACGC CAGCCTGCGC 
ATCGAGGAGC TCTTCAGCAT CGTCCGAGAC TTCCCAGACT CCCGGCCAGC CATCGAGGAC 
CTCAAGTACT GCCTGGAGAG GACGGACCAG AGGCAGCAGC TGCTCGTGTC CCTCAAGGCT 
GCCCTGGAGA CTCGGCTCCT GCATCCAGGC GTCAACACGT GTGACATCAT CACCCTCTAT 
ATCTCTGCCA TCAAGGCGCT GCGCGTGCTG GACCCTTCCA TGGTCATCCT GGAGGTGGCC 
TGTGAGCCTA TCCGCCGCTA CCTGAGGACG CGGGAGGACA CAGTGCGGCA GATTGTGGCT 
GGGCTGACGG GGGACTCGGA CGGGACAGGG GACCTGGCTG TTGAGCTGTC CAAGACCGAC 
CCGGCGAGCC TGGAGACAGG CCAGGACAGT GAGGATGACT CAGGCGAGCC AGAGGACTGG 
GTCCCGGACC CTGTGGATGC CGATCCAGGG AAGTCGAGCT CCAAGCGGCG TTCATCGGAC 
ATCATCAGCC TGCTGGTCAG CATCTACGGC AGCAAGGACC TCTTCATCAA TGAGTACCGC 
TCGCTGCTGG CCGACCGCCT GCTGCACCAG TTCAGCTTCA GCCCCGAGCG GGAGATCCGC 
AACGTGGAGC TGCTGAAGCT GCGCTTTGGC GAGGCCCCAA TGCACTTCTG TGAAGTCATG 
CTGAAGGACA TGGCGGACTC CCGCCGCATC AATGCCAACA TCCGGGAGGA GGATGAGAAG 
CGGCCAGCAG AGGAGCAGCC ACCGTTCGGG GTCTACGCTG TCATCCTGTC CAGTGAGTTC 
TGGCCGCCCT TCAAGGACGA GAAGCTGGAG GTCCCCGAGG ATATCAGGGC AGCCCTGGAG 
GCTTACTGCA AGAAGTATGA GCAGCTCAAG GCCATGCGGA CCCTCAGTTG GAAGCACACC 
CTGGGCCTGG TGACCATGGA CGTGGAGCTG GCCGACCGCA CGCTGTCTGT GGCGGTCACC 
CCAGTACAGG CGGTGATCTT GCTGTATTTT CAGGACCAAG CCAGCTGGAC CCTGGAGGAA 
CTGAGCAAGG CGGTGAAGAT GCCCGTGGCG CTGCTGCGGC GGCGGATGTC CGTGTGGCTG 
CAGCAGGGTG TGCTGCGTGA GGAGCCCCCC GGCACCTTCT CTGTCATTGA GGAGGAGCGG 
CCTCAGGACC GGGACAACAT GGTGCTCATT GACAGTGACG ACGAGAGCGA CTCCGGCATG 
GCCTCCCAGG CCGACCAGAA GGAGGAGGAG CTGCTGCTCT TCTGGACGTA CATCCAGGCC 
ATGCTGACCA ACCTGGAGAG CCTCTCACTG GATCGTATCT ACAACATGCT CCGCATGTTT 
GTGGTGACTG GGCCTGCACT GGCCGAGATT GACCTGCAGG AGCTGCAGGG CTACCTGCAG 
AAGAAGGTGC GGGACCAGCA GCTCGTCTAC TCGGCCGGCG TCTACCGCCT GCCCAAGAAC 
TGCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037498.1
CDS	29..2497
Translation	MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVEVLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLESRLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCFLRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDKQQCWCRQALEQFHQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWLGKVFLQDGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIEDLKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMFVVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNCS

Target ORF information:

RefSeq Version	NM_013366.4
Organism	Homo sapiens(human)
Definition	Homo sapiens anaphase promoting complex subunit 2 (ANAPC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013366.4

ORF Insert Sequence:

ATGGCGGCGG CAGTTGTGGT GGCGGAGGGG GACAGCGACT CCCGGCCCGG ACAGGAGTTG 
TTAGTGGCCT GGAACACCGT GAGCACCGGC CTGGTGCCGC CGGCTGCGCT GGGGCTGGTG 
TCTTCCCGGA CCAGCGGTGC AGTCCCGCCA AAGGAAGAGG AGCTCCGGGC GGCGGTGGAG 
GTTCTGAGGG GCCACGGGCT ACACTCGGTC CTGGAGGAGT GGTTCGTGGA GGTGCTGCAG 
AACGATCTGC AGGCCAACAT CTCCCCTGAG TTCTGGAATG CCATCTCCCA ATGCGAGAAC 
TCTGCGGATG AGCCCCAGTG CCTTTTGCTA CTCCTTGACG CTTTTGGCCT GCTGGAGAGC 
CGCCTGGATC CCTACCTGCG TAGCCTAGAG CTGCTGGAGA AATGGACTCG CCTGGGCTTG 
CTGATGGGCA CTGGTGCTCA GGGGCTGCGA GAAGAAGTCC ACACTATGTT GCGCGGAGTC 
TTGTTCTTTA GCACCCCCAG AACCTTCCAA GAGATGATCC AGCGTCTGTA TGGGTGCTTC 
TTGAGAGTCT ATATGCAGAG TAAGAGGAAG GGGGAAGGGG GCACAGACCC GGAACTGGAA 
GGGGAGCTGG ACAGCCGGTA TGCCCGTCGC CGGTACTACC GGCTCCTGCA GAGCCCGCTG 
TGTGCAGGGT GCAGCAGTGA CAAGCAACAG TGCTGGTGTC GCCAGGCTCT GGAGCAGTTC 
CATCAGCTCA GCCAGGTCTT ACACAGGCTC AGTCTGCTGG AGCGGGTCAG TGCCGAGGCT 
GTGACCACCA CCCTGCACCA GGTGACCCGG GAGAGGATGG AGGACCGTTG CCGGGGCGAG 
TACGAGCGCT CCTTCCTGCG TGAGTTCCAC AAGTGGATCG AGCGGGTGGT CGGCTGGCTC 
GGCAAGGTGT TCCTGCAGGA CGGCCCCGCC AGGCCCGCAT CTCCCGAGGC CGGCAACACC 
CTGCGCCGCT GGCGCTGCCA CGTGCAAAGG TTCTTCTACC GCATCTACGC CAGCCTGCGC 
ATCGAGGAGC TCTTCAGCAT CGTCCGAGAC TTCCCAGACT CCCGGCCAGC CATCGAGGAC 
CTCAAGTACT GCCTGGAGAG GACGGACCAG AGGCAGCAGC TGCTCGTGTC CCTCAAGGCT 
GCCCTGGAGA CTCGGCTCCT GCATCCAGGC GTCAACACGT GTGACATCAT CACCCTCTAT 
ATCTCTGCCA TCAAGGCGCT GCGCGTGCTG GACCCTTCCA TGGTCATCCT GGAGGTGGCC 
TGTGAGCCTA TCCGCCGCTA CCTGAGGACG CGGGAGGACA CAGTGCGGCA GATTGTGGCT 
GGGCTGACGG GGGACTCGGA CGGGACAGGG GACCTGGCTG TTGAGCTGTC CAAGACCGAC 
CCGGCGAGCC TGGAGACAGG CCAGGACAGT GAGGATGACT CAGGCGAGCC AGAGGACTGG 
GTCCCGGACC CTGTGGATGC CGATCCAGGG AAGTCGAGCT CCAAGCGGCG TTCATCGGAC 
ATCATCAGCC TGCTGGTCAG CATCTACGGC AGCAAGGACC TCTTCATCAA TGAGTACCGC 
TCGCTGCTGG CCGACCGCCT GCTGCACCAG TTCAGCTTCA GCCCCGAGCG GGAGATCCGC 
AACGTGGAGC TGCTGAAGCT GCGCTTTGGC GAGGCCCCAA TGCACTTCTG TGAAGTCATG 
CTGAAGGACA TGGCGGACTC CCGCCGCATC AATGCCAACA TCCGGGAGGA GGATGAGAAG 
CGGCCAGCAG AGGAGCAGCC ACCGTTCGGG GTCTACGCTG TCATCCTGTC CAGTGAGTTC 
TGGCCGCCCT TCAAGGACGA GAAGCTGGAG GTCCCCGAGG ATATCAGGGC AGCCCTGGAG 
GCTTACTGCA AGAAGTATGA GCAGCTCAAG GCCATGCGGA CCCTCAGTTG GAAGCACACC 
CTGGGCCTGG TGACCATGGA CGTGGAGCTG GCCGACCGCA CGCTGTCTGT GGCGGTCACC 
CCAGTACAGG CGGTGATCTT GCTGTATTTT CAGGACCAAG CCAGCTGGAC CCTGGAGGAA 
CTGAGCAAGG CGGTGAAGAT GCCCGTGGCG CTGCTGCGGC GGCGGATGTC CGTGTGGCTG 
CAGCAGGGTG TGCTGCGTGA GGAGCCCCCC GGCACCTTCT CTGTCATTGA GGAGGAGCGG 
CCTCAGGACC GGGACAACAT GGTGCTCATT GACAGTGACG ACGAGAGCGA CTCCGGCATG 
GCCTCCCAGG CCGACCAGAA GGAGGAGGAG CTGCTGCTCT TCTGGACGTA CATCCAGGCC 
ATGCTGACCA ACCTGGAGAG CCTCTCACTG GATCGTATCT ACAACATGCT CCGCATGTTT 
GTGGTGACTG GGCCTGCACT GGCCGAGATT GACCTGCAGG AGCTGCAGGG CTACCTGCAG 
AAGAAGGTGC GGGACCAGCA GCTCGTCTAC TCGGCCGGCG TCTACCGCCT GCCCAAGAAC 
TGCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ANAPC2 ( NM_013366.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037498.1 Homo sapiens anaphase promoting complex subunit 2 (ANAPC2), mRNA.

Price & Availability↑

CloneID	OHu13061
Clone ID Related Accession (Same CDS sequence)	NM_013366.4 , NM_013366.3
Accession Version	NM_013366.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2469bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	anaphase-promoting complex subunit 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU526961.1, BM925063.1 and BC032503.1. On or before Mar 4, 2006 this sequence version replaced XM_942539.1, XM_946085.1, XM_946087.1, XM_946089.1, NM_013366.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032503.1, SRR1163658.239610.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CAGTTGTGGT GGCGGAGGGG GACAGCGACT CCCGGCCCGG ACAGGAGTTG 
TTAGTGGCCT GGAACACCGT GAGCACCGGC CTGGTGCCGC CGGCTGCGCT GGGGCTGGTG 
TCTTCCCGGA CCAGCGGTGC AGTCCCGCCA AAGGAAGAGG AGCTCCGGGC GGCGGTGGAG 
GTTCTGAGGG GCCACGGGCT ACACTCGGTC CTGGAGGAGT GGTTCGTGGA GGTGCTGCAG 
AACGATCTGC AGGCCAACAT CTCCCCTGAG TTCTGGAATG CCATCTCCCA ATGCGAGAAC 
TCTGCGGATG AGCCCCAGTG CCTTTTGCTA CTCCTTGACG CTTTTGGCCT GCTGGAGAGC 
CGCCTGGATC CCTACCTGCG TAGCCTAGAG CTGCTGGAGA AATGGACTCG CCTGGGCTTG 
CTGATGGGCA CTGGTGCTCA GGGGCTGCGA GAAGAAGTCC ACACTATGTT GCGCGGAGTC 
TTGTTCTTTA GCACCCCCAG AACCTTCCAA GAGATGATCC AGCGTCTGTA TGGGTGCTTC 
TTGAGAGTCT ATATGCAGAG TAAGAGGAAG GGGGAAGGGG GCACAGACCC GGAACTGGAA 
GGGGAGCTGG ACAGCCGGTA TGCCCGTCGC CGGTACTACC GGCTCCTGCA GAGCCCGCTG 
TGTGCAGGGT GCAGCAGTGA CAAGCAACAG TGCTGGTGTC GCCAGGCTCT GGAGCAGTTC 
CATCAGCTCA GCCAGGTCTT ACACAGGCTC AGTCTGCTGG AGCGGGTCAG TGCCGAGGCT 
GTGACCACCA CCCTGCACCA GGTGACCCGG GAGAGGATGG AGGACCGTTG CCGGGGCGAG 
TACGAGCGCT CCTTCCTGCG TGAGTTCCAC AAGTGGATCG AGCGGGTGGT CGGCTGGCTC 
GGCAAGGTGT TCCTGCAGGA CGGCCCCGCC AGGCCCGCAT CTCCCGAGGC CGGCAACACC 
CTGCGCCGCT GGCGCTGCCA CGTGCAAAGG TTCTTCTACC GCATCTACGC CAGCCTGCGC 
ATCGAGGAGC TCTTCAGCAT CGTCCGAGAC TTCCCAGACT CCCGGCCAGC CATCGAGGAC 
CTCAAGTACT GCCTGGAGAG GACGGACCAG AGGCAGCAGC TGCTCGTGTC CCTCAAGGCT 
GCCCTGGAGA CTCGGCTCCT GCATCCAGGC GTCAACACGT GTGACATCAT CACCCTCTAT 
ATCTCTGCCA TCAAGGCGCT GCGCGTGCTG GACCCTTCCA TGGTCATCCT GGAGGTGGCC 
TGTGAGCCTA TCCGCCGCTA CCTGAGGACG CGGGAGGACA CAGTGCGGCA GATTGTGGCT 
GGGCTGACGG GGGACTCGGA CGGGACAGGG GACCTGGCTG TTGAGCTGTC CAAGACCGAC 
CCGGCGAGCC TGGAGACAGG CCAGGACAGT GAGGATGACT CAGGCGAGCC AGAGGACTGG 
GTCCCGGACC CTGTGGATGC CGATCCAGGG AAGTCGAGCT CCAAGCGGCG TTCATCGGAC 
ATCATCAGCC TGCTGGTCAG CATCTACGGC AGCAAGGACC TCTTCATCAA TGAGTACCGC 
TCGCTGCTGG CCGACCGCCT GCTGCACCAG TTCAGCTTCA GCCCCGAGCG GGAGATCCGC 
AACGTGGAGC TGCTGAAGCT GCGCTTTGGC GAGGCCCCAA TGCACTTCTG TGAAGTCATG 
CTGAAGGACA TGGCGGACTC CCGCCGCATC AATGCCAACA TCCGGGAGGA GGATGAGAAG 
CGGCCAGCAG AGGAGCAGCC ACCGTTCGGG GTCTACGCTG TCATCCTGTC CAGTGAGTTC 
TGGCCGCCCT TCAAGGACGA GAAGCTGGAG GTCCCCGAGG ATATCAGGGC AGCCCTGGAG 
GCTTACTGCA AGAAGTATGA GCAGCTCAAG GCCATGCGGA CCCTCAGTTG GAAGCACACC 
CTGGGCCTGG TGACCATGGA CGTGGAGCTG GCCGACCGCA CGCTGTCTGT GGCGGTCACC 
CCAGTACAGG CGGTGATCTT GCTGTATTTT CAGGACCAAG CCAGCTGGAC CCTGGAGGAA 
CTGAGCAAGG CGGTGAAGAT GCCCGTGGCG CTGCTGCGGC GGCGGATGTC CGTGTGGCTG 
CAGCAGGGTG TGCTGCGTGA GGAGCCCCCC GGCACCTTCT CTGTCATTGA GGAGGAGCGG 
CCTCAGGACC GGGACAACAT GGTGCTCATT GACAGTGACG ACGAGAGCGA CTCCGGCATG 
GCCTCCCAGG CCGACCAGAA GGAGGAGGAG CTGCTGCTCT TCTGGACGTA CATCCAGGCC 
ATGCTGACCA ACCTGGAGAG CCTCTCACTG GATCGTATCT ACAACATGCT CCGCATGTTT 
GTGGTGACTG GGCCTGCACT GGCCGAGATT GACCTGCAGG AGCTGCAGGG CTACCTGCAG 
AAGAAGGTGC GGGACCAGCA GCTCGTCTAC TCGGCCGGCG TCTACCGCCT GCCCAAGAAC 
TGCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037498.1
CDS	74..2542
Translation	MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVEVLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLESRLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCFLRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDKQQCWCRQALEQFHQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWLGKVFLQDGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIEDLKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMFVVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNCS

Target ORF information:

RefSeq Version	NM_013366.3
Organism	Homo sapiens(human)
Definition	Homo sapiens anaphase promoting complex subunit 2 (ANAPC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013366.3

ORF Insert Sequence:

ATGGCGGCGG CAGTTGTGGT GGCGGAGGGG GACAGCGACT CCCGGCCCGG ACAGGAGTTG 
TTAGTGGCCT GGAACACCGT GAGCACCGGC CTGGTGCCGC CGGCTGCGCT GGGGCTGGTG 
TCTTCCCGGA CCAGCGGTGC AGTCCCGCCA AAGGAAGAGG AGCTCCGGGC GGCGGTGGAG 
GTTCTGAGGG GCCACGGGCT ACACTCGGTC CTGGAGGAGT GGTTCGTGGA GGTGCTGCAG 
AACGATCTGC AGGCCAACAT CTCCCCTGAG TTCTGGAATG CCATCTCCCA ATGCGAGAAC 
TCTGCGGATG AGCCCCAGTG CCTTTTGCTA CTCCTTGACG CTTTTGGCCT GCTGGAGAGC 
CGCCTGGATC CCTACCTGCG TAGCCTAGAG CTGCTGGAGA AATGGACTCG CCTGGGCTTG 
CTGATGGGCA CTGGTGCTCA GGGGCTGCGA GAAGAAGTCC ACACTATGTT GCGCGGAGTC 
TTGTTCTTTA GCACCCCCAG AACCTTCCAA GAGATGATCC AGCGTCTGTA TGGGTGCTTC 
TTGAGAGTCT ATATGCAGAG TAAGAGGAAG GGGGAAGGGG GCACAGACCC GGAACTGGAA 
GGGGAGCTGG ACAGCCGGTA TGCCCGTCGC CGGTACTACC GGCTCCTGCA GAGCCCGCTG 
TGTGCAGGGT GCAGCAGTGA CAAGCAACAG TGCTGGTGTC GCCAGGCTCT GGAGCAGTTC 
CATCAGCTCA GCCAGGTCTT ACACAGGCTC AGTCTGCTGG AGCGGGTCAG TGCCGAGGCT 
GTGACCACCA CCCTGCACCA GGTGACCCGG GAGAGGATGG AGGACCGTTG CCGGGGCGAG 
TACGAGCGCT CCTTCCTGCG TGAGTTCCAC AAGTGGATCG AGCGGGTGGT CGGCTGGCTC 
GGCAAGGTGT TCCTGCAGGA CGGCCCCGCC AGGCCCGCAT CTCCCGAGGC CGGCAACACC 
CTGCGCCGCT GGCGCTGCCA CGTGCAAAGG TTCTTCTACC GCATCTACGC CAGCCTGCGC 
ATCGAGGAGC TCTTCAGCAT CGTCCGAGAC TTCCCAGACT CCCGGCCAGC CATCGAGGAC 
CTCAAGTACT GCCTGGAGAG GACGGACCAG AGGCAGCAGC TGCTCGTGTC CCTCAAGGCT 
GCCCTGGAGA CTCGGCTCCT GCATCCAGGC GTCAACACGT GTGACATCAT CACCCTCTAT 
ATCTCTGCCA TCAAGGCGCT GCGCGTGCTG GACCCTTCCA TGGTCATCCT GGAGGTGGCC 
TGTGAGCCTA TCCGCCGCTA CCTGAGGACG CGGGAGGACA CAGTGCGGCA GATTGTGGCT 
GGGCTGACGG GGGACTCGGA CGGGACAGGG GACCTGGCTG TTGAGCTGTC CAAGACCGAC 
CCGGCGAGCC TGGAGACAGG CCAGGACAGT GAGGATGACT CAGGCGAGCC AGAGGACTGG 
GTCCCGGACC CTGTGGATGC CGATCCAGGG AAGTCGAGCT CCAAGCGGCG TTCATCGGAC 
ATCATCAGCC TGCTGGTCAG CATCTACGGC AGCAAGGACC TCTTCATCAA TGAGTACCGC 
TCGCTGCTGG CCGACCGCCT GCTGCACCAG TTCAGCTTCA GCCCCGAGCG GGAGATCCGC 
AACGTGGAGC TGCTGAAGCT GCGCTTTGGC GAGGCCCCAA TGCACTTCTG TGAAGTCATG 
CTGAAGGACA TGGCGGACTC CCGCCGCATC AATGCCAACA TCCGGGAGGA GGATGAGAAG 
CGGCCAGCAG AGGAGCAGCC ACCGTTCGGG GTCTACGCTG TCATCCTGTC CAGTGAGTTC 
TGGCCGCCCT TCAAGGACGA GAAGCTGGAG GTCCCCGAGG ATATCAGGGC AGCCCTGGAG 
GCTTACTGCA AGAAGTATGA GCAGCTCAAG GCCATGCGGA CCCTCAGTTG GAAGCACACC 
CTGGGCCTGG TGACCATGGA CGTGGAGCTG GCCGACCGCA CGCTGTCTGT GGCGGTCACC 
CCAGTACAGG CGGTGATCTT GCTGTATTTT CAGGACCAAG CCAGCTGGAC CCTGGAGGAA 
CTGAGCAAGG CGGTGAAGAT GCCCGTGGCG CTGCTGCGGC GGCGGATGTC CGTGTGGCTG 
CAGCAGGGTG TGCTGCGTGA GGAGCCCCCC GGCACCTTCT CTGTCATTGA GGAGGAGCGG 
CCTCAGGACC GGGACAACAT GGTGCTCATT GACAGTGACG ACGAGAGCGA CTCCGGCATG 
GCCTCCCAGG CCGACCAGAA GGAGGAGGAG CTGCTGCTCT TCTGGACGTA CATCCAGGCC 
ATGCTGACCA ACCTGGAGAG CCTCTCACTG GATCGTATCT ACAACATGCT CCGCATGTTT 
GTGGTGACTG GGCCTGCACT GGCCGAGATT GACCTGCAGG AGCTGCAGGG CTACCTGCAG 
AAGAAGGTGC GGGACCAGCA GCTCGTCTAC TCGGCCGGCG TCTACCGCCT GCCCAAGAAC 
TGCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The expression pattern of APC2 and APC7 in various cancer cell lines and AML patients.
Advances in medical sciences60(2)259-63(2015 Sep)
Rahimi H,Ahmadzadeh A,Yousef-amoli S,Kokabee L,Shokrgozar MA,Mahdian R,Karimipoor M

Atomic structure of the APC/C and its mechanism of protein ubiquitination.
Nature522(7557)450-454(2015 Jun)
Chang L,Zhang Z,Yang J,McLaughlin SH,Barford D

SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.
The EMBO journal33(22)2643-58(2014 Nov)
van der Lelij P,Stocsits RR,Ladurner R,Petzold G,Kreidl E,Koch B,Schmitz J,Neumann B,Ellenberg J,Peters JM

The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2.
Cell cycle (Georgetown, Tex.)13(13)2101-9(2014)
He Y,Tollini L,Kim TH,Itahana Y,Zhang Y

Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex.
Nature cell biology15(7)797-806(2013 Jul)
Wang W,Kirschner MW

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ANAPC2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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