VPREB3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VPREB3
Entrez Gene ID	29802
Full Name	V-set pre-B cell surrogate light chain 3
Synonyms	8HS20,N27C7-2
General protein information	Preferred Names V-set pre-B cell surrogate light chain 3 Names pre-B lymphocyte protein 3 pre-B lymphocyte 3 pre-B lymphocyte gene 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.23\|22q11
Summary	The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015].
Disorder MIM:	605017

mRNA and Protein(s)

mRNA	Protein	Name
NM_013378.3	NP_037510.1	pre-B lymphocyte protein 3 precursor
NM_013378.2	NP_037510.1	pre-B lymphocyte protein 3 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VPREB3	XP_001169411.1
Canis lupus familiaris (dog)	VPREB3	XP_003433506.2
Rattus norvegicus (Norway rat)	Vpreb3	NP_001102400.1
Gallus gallus (chicken)	VPREB3	XP_415223.1
Bos taurus (cattle)	VPREB3	XP_002694736.2
Homo sapiens (human)	VPREB3	NP_037510.1
	VPREB3	XP_001083104.2
Mus musculus (house mouse)	Vpreb3	NP_033540.1

Gene Ontology
Bibliography

Related articles in PubMed

Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic Human Tissues.
Felizola SJ, Katsu K, Ise K, Nakamura Y, Arai Y, Satoh F, Sasano H
Endocrine pathology26(2)119-28(2015 May)

The combined expression of VPREB3 and ID3 represents a new helpful tool for the routine diagnosis of mature aggressive B-cell lymphomas.
Soldini D, Georgis A, Montagna C, Sch?ffler PJ, Martin V, Curioni-Fontecedro A, Martinez A, Tinguely M
Hematological oncology32(3)120-5(2014 Sep)

The pre-B-cell receptor associated protein VpreB3 is a useful diagnostic marker for identifying c-MYC translocated lymphomas.
Rodig SJ, Kutok JL, Paterson JC, Nitta H, Zhang W, Chapuy B, Tumwine LK, Montes-Moreno S, Agostinelli C, Johnson NA, Ben-Neriah S, Farinha P, Shipp MA, Piris MA, Grogan TM, Pileri SA, Gascoyne RD, Marafioti T
Haematologica95(12)2056-62(2010 Dec)

Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript.
Rangel R, McKeller MR, Sims-Mourtada JC, Kashi C, Cain K, Wieder ED, Molldrem JJ, Pham LV, Ford RJ, Yotnda P, Guret C, Franc?s V, Martinez-Valdez H
The Journal of biological chemistry280(18)17807-14(2005 May)

Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells.
Rosnet O, Blanco-Betancourt C, Grivel K, Richter K, Schiff C
The Journal of biological chemistry279(11)10228-36(2004 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A possible role for VPREB3 in aldosterone biosynthesis.
Title: Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic Human Tissues.

the combined immunohistochemical detection of VPREB3 and ID3 is applicable to the routine diagnostic in case of mature aggressive B-cell lymphomas.
Title: The combined expression of VPREB3 and ID3 represents a new helpful tool for the routine diagnosis of mature aggressive B-cell lymphomas.

Data show that the absence of VpreB3 is virtually always associated with wild-type c-MYC alleles.
Title: The pre-B-cell receptor associated protein VpreB3 is a useful diagnostic marker for identifying c-MYC translocated lymphomas.

the present study confirms the co-existence of surrogate lambda and kappa receptors that are proposed to work in concert to promote B lymphocyte maturation.
Title: Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript.

VpreB3 may play a role in the regulation of the maturation and secretion of free IgLC in chicken B cells
Title: Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells.

The following VPREB3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VPREB3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23400	NM_013378.3 Latest version!	Homo sapiens V-set pre-B cell surrogate light chain 3 (VPREB3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu23400	NM_013378.2	Homo sapiens V-set pre-B cell surrogate light chain 3 (VPREB3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VPREB3 ( NM_013378.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037510.1 Homo sapiens V-set pre-B cell surrogate light chain 3 (VPREB3), mRNA.

Price & Availability↑

CloneID	OHu23400
Clone ID Related Accession (Same CDS sequence)	NM_013378.3 , NM_013378.2
Accession Version	NM_013378.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	pre-B lymphocyte protein 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY359000.1, AF163825.1 and BQ899182.1. On Nov 22, 2018 this sequence version replaced NM_013378.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020666.1, AY359000.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149876, SAMEA2150385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000248948.4/ ENSP00000248948.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCTGCC GGTGCCTCAG CTTCCTTCTG ATGGGGACCT TCCTGTCAGT TTCCCAGACA 
GTCCTGGCCC AGCTGGATGC ACTGCTGGTC TTCCCAGGCC AAGTGGCTCA ACTCTCCTGC 
ACGCTCAGCC CCCAGCACGT CACCATCAGG GACTACGGTG TGTCCTGGTA CCAGCAGCGG 
GCAGGCAGTG CCCCTCGATA TCTCCTCTAC TACCGCTCGG AGGAGGATCA CCACCGGCCT 
GCTGACATCC CCGATCGATT CTCGGCAGCC AAGGATGAGG CCCACAATGC CTGTGTCCTC 
ACCATTAGTC CCGTGCAGCC TGAAGACGAC GCGGATTACT ACTGCTCTGT TGGCTACGGC 
TTTAGTCCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037510.1
CDS	63..434
Translation	MACRCLSFLLMGTFLSVSQTVLAQLDALLVFPGQVAQLSCTLSPQHVTIRDYGVSWYQQRAGSAPRYLLYYRSEEDHHRPADIPDRFSAAKDEAHNACVLTISPVQPEDDADYYCSVGYGFSP

Target ORF information:

RefSeq Version	NM_013378.3
Organism	Homo sapiens(human)
Definition	Homo sapiens V-set pre-B cell surrogate light chain 3 (VPREB3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013378.3

ORF Insert Sequence:

ATGGCCTGCC GGTGCCTCAG CTTCCTTCTG ATGGGGACCT TCCTGTCAGT TTCCCAGACA 
GTCCTGGCCC AGCTGGATGC ACTGCTGGTC TTCCCAGGCC AAGTGGCTCA ACTCTCCTGC 
ACGCTCAGCC CCCAGCACGT CACCATCAGG GACTACGGTG TGTCCTGGTA CCAGCAGCGG 
GCAGGCAGTG CCCCTCGATA TCTCCTCTAC TACCGCTCGG AGGAGGATCA CCACCGGCCT 
GCTGACATCC CCGATCGATT CTCGGCAGCC AAGGATGAGG CCCACAATGC CTGTGTCCTC 
ACCATTAGTC CCGTGCAGCC TGAAGACGAC GCGGATTACT ACTGCTCTGT TGGCTACGGC 
TTTAGTCCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VPREB3 ( NM_013378.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_037510.1 Homo sapiens V-set pre-B cell surrogate light chain 3 (VPREB3), mRNA.

Price & Availability↑

CloneID	OHu23400
Clone ID Related Accession (Same CDS sequence)	NM_013378.3 , NM_013378.2
Accession Version	NM_013378.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	pre-B lymphocyte protein 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY359000.1, AF163825.1 and BQ899182.1. On Sep 25, 2008 this sequence version replaced NM_013378.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020666.1, SRR1163657.29029.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149876, SAMEA2150385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTGCC GGTGCCTCAG CTTCCTTCTG ATGGGGACCT TCCTGTCAGT TTCCCAGACA 
GTCCTGGCCC AGCTGGATGC ACTGCTGGTC TTCCCAGGCC AAGTGGCTCA ACTCTCCTGC 
ACGCTCAGCC CCCAGCACGT CACCATCAGG GACTACGGTG TGTCCTGGTA CCAGCAGCGG 
GCAGGCAGTG CCCCTCGATA TCTCCTCTAC TACCGCTCGG AGGAGGATCA CCACCGGCCT 
GCTGACATCC CCGATCGATT CTCGGCAGCC AAGGATGAGG CCCACAATGC CTGTGTCCTC 
ACCATTAGTC CCGTGCAGCC TGAAGACGAC GCGGATTACT ACTGCTCTGT TGGCTACGGC 
TTTAGTCCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037510.1
CDS	81..452
Translation	MACRCLSFLLMGTFLSVSQTVLAQLDALLVFPGQVAQLSCTLSPQHVTIRDYGVSWYQQRAGSAPRYLLYYRSEEDHHRPADIPDRFSAAKDEAHNACVLTISPVQPEDDADYYCSVGYGFSP

Target ORF information:

RefSeq Version	NM_013378.2
Organism	Homo sapiens(human)
Definition	Homo sapiens V-set pre-B cell surrogate light chain 3 (VPREB3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013378.2

ORF Insert Sequence:

ATGGCCTGCC GGTGCCTCAG CTTCCTTCTG ATGGGGACCT TCCTGTCAGT TTCCCAGACA 
GTCCTGGCCC AGCTGGATGC ACTGCTGGTC TTCCCAGGCC AAGTGGCTCA ACTCTCCTGC 
ACGCTCAGCC CCCAGCACGT CACCATCAGG GACTACGGTG TGTCCTGGTA CCAGCAGCGG 
GCAGGCAGTG CCCCTCGATA TCTCCTCTAC TACCGCTCGG AGGAGGATCA CCACCGGCCT 
GCTGACATCC CCGATCGATT CTCGGCAGCC AAGGATGAGG CCCACAATGC CTGTGTCCTC 
ACCATTAGTC CCGTGCAGCC TGAAGACGAC GCGGATTACT ACTGCTCTGT TGGCTACGGC 
TTTAGTCCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic Human Tissues.
Endocrine pathology26(2)119-28(2015 May)
Felizola SJ,Katsu K,Ise K,Nakamura Y,Arai Y,Satoh F,Sasano H

The combined expression of VPREB3 and ID3 represents a new helpful tool for the routine diagnosis of mature aggressive B-cell lymphomas.
Hematological oncology32(3)120-5(2014 Sep)
Soldini D,Georgis A,Montagna C,Sch?ffler PJ,Martin V,Curioni-Fontecedro A,Martinez A,Tinguely M

The pre-B-cell receptor associated protein VpreB3 is a useful diagnostic marker for identifying c-MYC translocated lymphomas.
Haematologica95(12)2056-62(2010 Dec)
Rodig SJ,Kutok JL,Paterson JC,Nitta H,Zhang W,Chapuy B,Tumwine LK,Montes-Moreno S,Agostinelli C,Johnson NA,Ben-Neriah S,Farinha P,Shipp MA,Piris MA,Grogan TM,Pileri SA,Gascoyne RD,Marafioti T

Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript.
The Journal of biological chemistry280(18)17807-14(2005 May)
Rangel R,McKeller MR,Sims-Mourtada JC,Kashi C,Cain K,Wieder ED,Molldrem JJ,Pham LV,Ford RJ,Yotnda P,Guret C,Franc?s V,Martinez-Valdez H

Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells.
The Journal of biological chemistry279(11)10228-36(2004 Mar)
Rosnet O,Blanco-Betancourt C,Grivel K,Richter K,Schiff C

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VPREB3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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