CARD10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CARD10
Entrez Gene ID	29775
Full Name	caspase recruitment domain family member 10
Synonyms	BIMP1,CARMA3
General protein information	Preferred Names caspase recruitment domain family member 10 Names caspase recruitment domain-containing protein 10 Bcl10 binding protein and activator of NFKB CARD-containing MAGUK 3 protein CARD-containing MAGUK protein 3 carma 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.1
Summary	The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008].
Disorder MIM:	607209

mRNA and Protein(s)

mRNA	Protein	Name
NM_014550.4	NP_055365.2	caspase recruitment domain-containing protein 10
NM_014550.3	NP_055365.2	caspase recruitment domain-containing protein 10

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Card10	NP_570929.2
Homo sapiens (human)	CARD10	NP_055365.2
Rattus norvegicus (Norway rat)	Card10	NP_001124026.1
Pan troglodytes (chimpanzee)	CARD10	XP_001160660.2
	CARD10	XP_002798432.1
Canis lupus familiaris (dog)	CARD10	XP_005625959.1
Bos taurus (cattle)	CARD10	XP_002687740.1
Gallus gallus (chicken)	CARD10	XP_416277.4

Gene Ontology
Bibliography

Related articles in PubMed

The CARMA3-Bcl10-MALT1 Signalosome Drives NF-?B Activation and Promotes Aggressiveness in Angiotensin II Receptor-positive Breast Cancer.
Ekambaram P, Lee JL, Hubel NE, Hu D, Yerneni S, Campbell PG, Pollock N, Klei LR, Concel VJ, Delekta PC, Chinnaiyan AM, Tomlins SA, Rhodes DR, Priedigkeit N, Lee AV, Oesterreich S, McAllister-Lucas L, Lucas PC
Cancer research(2017 Dec)

The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-?B activation and cell survival.
Zhang S, Pan D, Jia XM, Lin X, Zhao X
Protein & cell8(11)856-860(2017 11)

Lack of association between CARD10/CARMA3 tag SNPs and psoriasis vulgaris in the southern Chinese population.
Shi G, Zhang MF, Liao PY, Wang TT, Li SJ, Fan YM, Zhu KJ
Genetics and molecular research : GMR16(1)(2017 Mar)

Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population.
Migita K, Jiuchi Y, Furukawa H, Nakamura M, Komori A, Yasunami M, Kozuru H, Abiru S, Yamasaki K, Nagaoka S, Hashimoto S, Bekki S, Yoshizawa K, Shimada M, Kouno H, Kamitsukasa H, Komatsu T, Hijioka T, Nakamuta M, Naganuma A, Yamashita H, Nishimura H, Ohta H, Nakamura Y, Ario K, Oohara Y, Sugi K, Tomizawa M, Sato T, Takahashi H, Muro T, Makita F, Mita E, Sakai H, Yatsuhashi H
BMC research notes8777(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Card10 polymorphisms may not be linked with psoriasis vulgaris in the southern Han Chinese population.
Title: Lack of association between CARD10/CARMA3 tag SNPs and psoriasis vulgaris in the southern Chinese population.

Findings indicate that CARMA3 may suppress the activation of the P38 MAPK signaling pathway to regulate invasion, migration and apoptosis of lung cancer cells by activating NF-small ka, CyrillicB (P65) in the nucleus.
Title: CARMA3 regulates the invasion, migration, and apoptosis of non-small cell lung cancer cells by activating NF-?B and suppressing the P38 MAPK signaling pathway.

Data indicate no association between caspase recruitment domain family, member 10 protein (CARD10) polymorphism rs6000782 and type 1 autoimmune hepatitis (AIH) in a Japanese population.
Title: Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population.

miR-24 inhibited cell proliferation, invasion and epithelial to mesenchymal transition in bladder cancer cells by downregulation of CARMA3
Title: MicroRNA-24 upregulation inhibits proliferation, metastasis and induces apoptosis in bladder cancer cells by targeting CARMA3.

A novel mechanism of CARMA3 in lung cancer stemness and metastasis through the negative regulation of NME2 was identified.
Title: CARMA3 Represses Metastasis Suppressor NME2 to Promote Lung Cancer Stemness and Metastasis.

The following CARD10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CARD10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19929	NM_014550.4 Latest version!	Homo sapiens caspase recruitment domain family member 10 (CARD10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$399.50-$559.30 $799.00
View Old Accession Versions >>
OHu19929	NM_014550.3	Homo sapiens caspase recruitment domain family member 10 (CARD10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$399.50-$559.30 $799.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CARD10 ( NM_014550.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055365.2 Homo sapiens caspase recruitment domain family member 10 (CARD10), mRNA.

Price & Availability↑

CloneID	OHu19929
Clone ID Related Accession (Same CDS sequence)	NM_014550.4 , NM_014550.3
Accession Version	NM_014550.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3099bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	caspase recruitment domain-containing protein 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL022315.1, AY032928.1, BC032058.1, AK057334.1 and AY028896.1. On Nov 22, 2018 this sequence version replaced NM_014550.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY028896.1, AY032928.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000251973.10/ ENSP00000251973.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGGGCC GGGCGGAGGC GGGGGAGGCC GAGGAGGAGG CCGGGGCCGG CTCGGGGTCT 
GAGGCGGAGG AGGACGCGCT GTGGGAGCGA ATCGAGGGCG TCCGGCATCG GCTGGCTCGC 
GCCCTGAACC CGGCCAAGCT CACGCCGTAT CTGCGCCAGT GCCGGGTCAT CGACGAGCAG 
GACGAGGAGG AGGTGCTGAG CACCTACCGC TTCCCGTGCC GCGTCAACCG CACCGGGCGC 
CTGATGGACA TCTTGCGCTG CCGTGGCAAG AGGGGCTATG AGGCCTTCCT GGAAGCCCTG 
GAGTTCTACT ACCCCGAACA CTTCACGCTG CTCACGGGCC AGGAACCCGC CCAGCGCTGC 
TCCATGATCC TCGATGAGGA GGGGCCTGAG GGCCTGACCC AATTCTTGAT GACAGAGGTG 
CGACGGCTGC GGGAAGCTCG CAAGAGCCAG CTGCAGCGGG AGCAGCAACT GCAGGCCCGG 
GGCCGGGTGC TCGAGGAGGA GCGGGCAGGG CTGGAGCAGC GGCTGCGGGA CCAGCAGCAG 
GCTCAGGAGC GCTGTCAACG GCTGCGGGAG GACTGGGAGG CGGGCAGCCT GGAGCTGCTG 
CGGCTCAAGG ATGAGAACTA CATGATCGCC ATGCGCCTGG CACAGCTCAG TGAGGAGAAG 
AACTCGGCTG TACTTCGCAG CCGTGACCTG CAGCTGGCGG TGGATCAGCT CAAGCTCAAA 
GTGAGTCGGC TGGAGGAAGA GTGTGCACTG CTTCGAAGGG CCAGGGGCCC GCCCCCTGGG 
GCAGAGGAGA AGGAGAAGGA GAAGGAGAAG GAGAAGGAGC CAGACAATGT GGACCTTGTC 
TCTGAGCTGC GTGCTGAGAA CCAGCGGCTG ACGGCGTCAC TGCGGGAGTT GCAGGAGGGC 
CTGCAGCAGG AGGCGAGCCG GCCGGGGGCC CCGGGCTCCG AGCGCATCCT GCTGGACATC 
CTAGAGCATG ACTGGCGGGA GGCGCAGGAC AGCAGGCAGG AGCTGTGCCA GAAGCTGCAT 
GCCGTGCAGG GGGAGCTGCA GTGGGCCGAG GAGCTGCGCG ACCAGTACCT GCAGGAGATG 
GAAGACCTGC GGCTCAAGCA CCGCACGCTG CAGAAGGACT GTGACCTGTA CAAGCACCGC 
ATGGCCACTG TCCTGGCCCA ACTGGAGGAG ATTGAGAAGG AGCGAGACCA GGCCATCCAG 
AGCCGTGACC GGATCCAGTT GCAGTACTCA CAGAGCCTCA TCGAGAAGGA CCAGTACCGC 
AAGCAGGTGC GGGGCCTGGA GGCGGAGCGG GATGAGCTGC TGACAACGCT CACCAGCCTG 
GAGGGCACCA AGGCTCTGCT GGAGGTTCAG CTGCAGCGGG CCCAGGGTGG CACCTGCCTC 
AAGGCCTGTG CCTCCTCCCA TTCCCTGTGC TCCAACCTCA GCAGCACTTG GAGCCTGAGC 
GAGTTCCCCT CCCCTCTGGG AGGCCCAGAA GCAACTGGGG AGGCAGCTGT CATGGGGGGA 
CCTGAGCCTC ACAACTCGGA GGAAGCCACA GACAGTGAAA AGGAGATCAA TCGGCTCTCC 
ATCCTGCCCT TCCCCCCCAG TGCCGGCTCC ATCCTCCGCC GGCAGCGTGA GGAAGACCCC 
GCACCCCCTA AGAGATCCTT CAGCAGCATG TCAGACATCA CAGGGAGTGT GACACTTAAG 
CCCTGGTCCC CTGGCCTCTC TTCGTCCTCA TCCTCTGACA GCGTGTGGCC TTTGGGAAAG 
CCGGAAGGCC TCCTGGCTCG GGGCTGTGGC CTGGACTTCC TCAACAGGTC TCTGGCTATT 
CGGGTGTCTG GCCGGAGCCC CCCAGGGGGC CCAGAGCCGC AGGACAAGGG ACCAGATGGA 
CTGTCGTTTT ATGGGGACAG ATGGTCTGGG GCTGTGGTGC GCAGGGTGCT GTCTGGGCCT 
GGGTCCGCCA GGATGGAACC AAGAGAGCAA AGGGTGGAAG CTGCTGGTCT GGAGGGGGCG 
TGCCTGGAAG CCGAGGCCCA GCAGAGAACC TTGCTCTGGA ATCAGGGGTC CACACTCCCC 
TCCCTGATGG ACTCGAAGGC CTGCCAGTCC TTCCACGAGG CCCTAGAAGC CTGGGCAAAG 
GGACCAGGTG CCGAGCCCTT CTACATTCGT GCCAACCTCA CCTTGCCTGA GAGGGCAGAT 
CCCCATGCCC TTTGCGTGAA AGCCCAAGAG ATCCTTCGAC TGGTGGACTC GGCATACAAG 
CGGAGGCAGG AATGGTTCTG CACCCGGGTT GACCCCCTCA CTCTGCGGGA CCTGGACCGG 
GGCACCGTGC CCAATTATCA GAGAGCCCAG CAGCTCCTAG AAGTTCAGGA GAAATGCCTG 
CCCTCCAGCC GGCACCGAGG CCCCCGCAGT AATCTGAAGA AGAGAGCCCT GGACCAGCTG 
CGGCTGGTGA GGCCCAAGCC CGTGGGGGCG CCTGCAGGGG ACTCCCCGGA TCAGCTGCTG 
CTGGAGCCCT GTGCAGAGCC GGAGCGGAGC CTCAGACCCT ACAGTTTGGT GCGGCCGCTA 
CTGGTGTCTG CCCTGCGGCC CGTGGTGCTG TTGCCTGAGT GCCTGGCGCC CCGGCTCATC 
CGTAACCTGC TAGACCTGCC CAGCTCCCGG CTGGACTTCC AAGTGTGCCC AGCGGAAAGC 
CTCTCTGGGG AGGAACTGTG CCCATCCTCA GCGCCTGGAG CCCCCAAGGC TCAGCCTGCC 
ACCCCTGGGC TAGGCAGCAG GATCCGGGCC ATCCAGGAGT CTGTTGGGAA GAAGCACTGC 
CTGCTGGAGC TGGGTGCTCG GGGTGTGCGG GAGCTGGTGC AGAACGAGAT CTACCCCATC 
GTCATCCACG TGGAGGTGAC TGAGAAGAAT GTCCGGGAAG TCAGGGGTCT GCTGGGCCGG 
CCGGGCTGGC GGGACTCAGA GCTGCTGCGG CAGTGCCGTG GCTCAGAGCA GGTGCTCTGG 
GGGCTGCCCT GCTCCTGGGT GCAGGTGCCC GCCCATGAGT GGGGACACGC AGAGGAGCTG 
GCCAAGGTGG TGCGCGGCCG CATCCTGCAG GAGCAGGCCC GCCTCGTGTG GGTGGAGTGC 
GGCAGCAGCA GAGGCTGCCC CAGCAGCAGT GAGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055365.2
CDS	216..3314
Translation	MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVECGSSRGCPSSSEA

Target ORF information:

RefSeq Version	NM_014550.4
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase recruitment domain family member 10 (CARD10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014550.4

ORF Insert Sequence:

ATGCCGGGCC GGGCGGAGGC GGGGGAGGCC GAGGAGGAGG CCGGGGCCGG CTCGGGGTCT 
GAGGCGGAGG AGGACGCGCT GTGGGAGCGA ATCGAGGGCG TCCGGCATCG GCTGGCTCGC 
GCCCTGAACC CGGCCAAGCT CACGCCGTAT CTGCGCCAGT GCCGGGTCAT CGACGAGCAG 
GACGAGGAGG AGGTGCTGAG CACCTACCGC TTCCCGTGCC GCGTCAACCG CACCGGGCGC 
CTGATGGACA TCTTGCGCTG CCGTGGCAAG AGGGGCTATG AGGCCTTCCT GGAAGCCCTG 
GAGTTCTACT ACCCCGAACA CTTCACGCTG CTCACGGGCC AGGAACCCGC CCAGCGCTGC 
TCCATGATCC TCGATGAGGA GGGGCCTGAG GGCCTGACCC AATTCTTGAT GACAGAGGTG 
CGACGGCTGC GGGAAGCTCG CAAGAGCCAG CTGCAGCGGG AGCAGCAACT GCAGGCCCGG 
GGCCGGGTGC TCGAGGAGGA GCGGGCAGGG CTGGAGCAGC GGCTGCGGGA CCAGCAGCAG 
GCTCAGGAGC GCTGTCAACG GCTGCGGGAG GACTGGGAGG CGGGCAGCCT GGAGCTGCTG 
CGGCTCAAGG ATGAGAACTA CATGATCGCC ATGCGCCTGG CACAGCTCAG TGAGGAGAAG 
AACTCGGCTG TACTTCGCAG CCGTGACCTG CAGCTGGCGG TGGATCAGCT CAAGCTCAAA 
GTGAGTCGGC TGGAGGAAGA GTGTGCACTG CTTCGAAGGG CCAGGGGCCC GCCCCCTGGG 
GCAGAGGAGA AGGAGAAGGA GAAGGAGAAG GAGAAGGAGC CAGACAATGT GGACCTTGTC 
TCTGAGCTGC GTGCTGAGAA CCAGCGGCTG ACGGCGTCAC TGCGGGAGTT GCAGGAGGGC 
CTGCAGCAGG AGGCGAGCCG GCCGGGGGCC CCGGGCTCCG AGCGCATCCT GCTGGACATC 
CTAGAGCATG ACTGGCGGGA GGCGCAGGAC AGCAGGCAGG AGCTGTGCCA GAAGCTGCAT 
GCCGTGCAGG GGGAGCTGCA GTGGGCCGAG GAGCTGCGCG ACCAGTACCT GCAGGAGATG 
GAAGACCTGC GGCTCAAGCA CCGCACGCTG CAGAAGGACT GTGACCTGTA CAAGCACCGC 
ATGGCCACTG TCCTGGCCCA ACTGGAGGAG ATTGAGAAGG AGCGAGACCA GGCCATCCAG 
AGCCGTGACC GGATCCAGTT GCAGTACTCA CAGAGCCTCA TCGAGAAGGA CCAGTACCGC 
AAGCAGGTGC GGGGCCTGGA GGCGGAGCGG GATGAGCTGC TGACAACGCT CACCAGCCTG 
GAGGGCACCA AGGCTCTGCT GGAGGTTCAG CTGCAGCGGG CCCAGGGTGG CACCTGCCTC 
AAGGCCTGTG CCTCCTCCCA TTCCCTGTGC TCCAACCTCA GCAGCACTTG GAGCCTGAGC 
GAGTTCCCCT CCCCTCTGGG AGGCCCAGAA GCAACTGGGG AGGCAGCTGT CATGGGGGGA 
CCTGAGCCTC ACAACTCGGA GGAAGCCACA GACAGTGAAA AGGAGATCAA TCGGCTCTCC 
ATCCTGCCCT TCCCCCCCAG TGCCGGCTCC ATCCTCCGCC GGCAGCGTGA GGAAGACCCC 
GCACCCCCTA AGAGATCCTT CAGCAGCATG TCAGACATCA CAGGGAGTGT GACACTTAAG 
CCCTGGTCCC CTGGCCTCTC TTCGTCCTCA TCCTCTGACA GCGTGTGGCC TTTGGGAAAG 
CCGGAAGGCC TCCTGGCTCG GGGCTGTGGC CTGGACTTCC TCAACAGGTC TCTGGCTATT 
CGGGTGTCTG GCCGGAGCCC CCCAGGGGGC CCAGAGCCGC AGGACAAGGG ACCAGATGGA 
CTGTCGTTTT ATGGGGACAG ATGGTCTGGG GCTGTGGTGC GCAGGGTGCT GTCTGGGCCT 
GGGTCCGCCA GGATGGAACC AAGAGAGCAA AGGGTGGAAG CTGCTGGTCT GGAGGGGGCG 
TGCCTGGAAG CCGAGGCCCA GCAGAGAACC TTGCTCTGGA ATCAGGGGTC CACACTCCCC 
TCCCTGATGG ACTCGAAGGC CTGCCAGTCC TTCCACGAGG CCCTAGAAGC CTGGGCAAAG 
GGACCAGGTG CCGAGCCCTT CTACATTCGT GCCAACCTCA CCTTGCCTGA GAGGGCAGAT 
CCCCATGCCC TTTGCGTGAA AGCCCAAGAG ATCCTTCGAC TGGTGGACTC GGCATACAAG 
CGGAGGCAGG AATGGTTCTG CACCCGGGTT GACCCCCTCA CTCTGCGGGA CCTGGACCGG 
GGCACCGTGC CCAATTATCA GAGAGCCCAG CAGCTCCTAG AAGTTCAGGA GAAATGCCTG 
CCCTCCAGCC GGCACCGAGG CCCCCGCAGT AATCTGAAGA AGAGAGCCCT GGACCAGCTG 
CGGCTGGTGA GGCCCAAGCC CGTGGGGGCG CCTGCAGGGG ACTCCCCGGA TCAGCTGCTG 
CTGGAGCCCT GTGCAGAGCC GGAGCGGAGC CTCAGACCCT ACAGTTTGGT GCGGCCGCTA 
CTGGTGTCTG CCCTGCGGCC CGTGGTGCTG TTGCCTGAGT GCCTGGCGCC CCGGCTCATC 
CGTAACCTGC TAGACCTGCC CAGCTCCCGG CTGGACTTCC AAGTGTGCCC AGCGGAAAGC 
CTCTCTGGGG AGGAACTGTG CCCATCCTCA GCGCCTGGAG CCCCCAAGGC TCAGCCTGCC 
ACCCCTGGGC TAGGCAGCAG GATCCGGGCC ATCCAGGAGT CTGTTGGGAA GAAGCACTGC 
CTGCTGGAGC TGGGTGCTCG GGGTGTGCGG GAGCTGGTGC AGAACGAGAT CTACCCCATC 
GTCATCCACG TGGAGGTGAC TGAGAAGAAT GTCCGGGAAG TCAGGGGTCT GCTGGGCCGG 
CCGGGCTGGC GGGACTCAGA GCTGCTGCGG CAGTGCCGTG GCTCAGAGCA GGTGCTCTGG 
GGGCTGCCCT GCTCCTGGGT GCAGGTGCCC GCCCATGAGT GGGGACACGC AGAGGAGCTG 
GCCAAGGTGG TGCGCGGCCG CATCCTGCAG GAGCAGGCCC GCCTCGTGTG GGTGGAGTGC 
GGCAGCAGCA GAGGCTGCCC CAGCAGCAGT GAGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CARD10 ( NM_014550.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055365.2 Homo sapiens caspase recruitment domain family member 10 (CARD10), mRNA.

Price & Availability↑

CloneID	OHu19929
Clone ID Related Accession (Same CDS sequence)	NM_014550.4 , NM_014550.3
Accession Version	NM_014550.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3099bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	caspase recruitment domain-containing protein 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY032928.1, BC032058.1, AK057334.1 and AY028896.1. On Aug 10, 2004 this sequence version replaced NM_014550.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY032928.1, AY028896.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGGCC GGGCGGAGGC GGGGGAGGCC GAGGAGGAGG CCGGGGCCGG CTCGGGGTCT 
GAGGCGGAGG AGGACGCGCT GTGGGAGCGA ATCGAGGGCG TCCGGCATCG GCTGGCTCGC 
GCCCTGAACC CGGCCAAGCT CACGCCGTAT CTGCGCCAGT GCCGGGTCAT CGACGAGCAG 
GACGAGGAGG AGGTGCTGAG CACCTACCGC TTCCCGTGCC GCGTCAACCG CACCGGGCGC 
CTGATGGACA TCTTGCGCTG CCGTGGCAAG AGGGGCTATG AGGCCTTCCT GGAAGCCCTG 
GAGTTCTACT ACCCCGAACA CTTCACGCTG CTCACGGGCC AGGAACCCGC CCAGCGCTGC 
TCCATGATCC TCGATGAGGA GGGGCCTGAG GGCCTGACCC AATTCTTGAT GACAGAGGTG 
CGACGGCTGC GGGAAGCTCG CAAGAGCCAG CTGCAGCGGG AGCAGCAACT GCAGGCCCGG 
GGCCGGGTGC TCGAGGAGGA GCGGGCAGGG CTGGAGCAGC GGCTGCGGGA CCAGCAGCAG 
GCTCAGGAGC GCTGTCAACG GCTGCGGGAG GACTGGGAGG CGGGCAGCCT GGAGCTGCTG 
CGGCTCAAGG ATGAGAACTA CATGATCGCC ATGCGCCTGG CACAGCTCAG TGAGGAGAAG 
AACTCGGCTG TACTTCGCAG CCGTGACCTG CAGCTGGCGG TGGATCAGCT CAAGCTCAAA 
GTGAGTCGGC TGGAGGAAGA GTGTGCACTG CTTCGAAGGG CCAGGGGCCC GCCCCCTGGG 
GCAGAGGAGA AGGAGAAGGA GAAGGAGAAG GAGAAGGAGC CAGACAATGT GGACCTTGTC 
TCTGAGCTGC GTGCTGAGAA CCAGCGGCTG ACGGCGTCAC TGCGGGAGTT GCAGGAGGGC 
CTGCAGCAGG AGGCGAGCCG GCCGGGGGCC CCGGGCTCCG AGCGCATCCT GCTGGACATC 
CTAGAGCATG ACTGGCGGGA GGCGCAGGAC AGCAGGCAGG AGCTGTGCCA GAAGCTGCAT 
GCCGTGCAGG GGGAGCTGCA GTGGGCCGAG GAGCTGCGCG ACCAGTACCT GCAGGAGATG 
GAAGACCTGC GGCTCAAGCA CCGCACGCTG CAGAAGGACT GTGACCTGTA CAAGCACCGC 
ATGGCCACTG TCCTGGCCCA ACTGGAGGAG ATTGAGAAGG AGCGAGACCA GGCCATCCAG 
AGCCGTGACC GGATCCAGTT GCAGTACTCA CAGAGCCTCA TCGAGAAGGA CCAGTACCGC 
AAGCAGGTGC GGGGCCTGGA GGCGGAGCGG GATGAGCTGC TGACAACGCT CACCAGCCTG 
GAGGGCACCA AGGCTCTGCT GGAGGTTCAG CTGCAGCGGG CCCAGGGTGG CACCTGCCTC 
AAGGCCTGTG CCTCCTCCCA TTCCCTGTGC TCCAACCTCA GCAGCACTTG GAGCCTGAGC 
GAGTTCCCCT CCCCTCTGGG AGGCCCAGAA GCAACTGGGG AGGCAGCTGT CATGGGGGGA 
CCTGAGCCTC ACAACTCGGA GGAAGCCACA GACAGTGAAA AGGAGATCAA TCGGCTCTCC 
ATCCTGCCCT TCCCCCCCAG TGCCGGCTCC ATCCTCCGCC GGCAGCGTGA GGAAGACCCC 
GCACCCCCTA AGAGATCCTT CAGCAGCATG TCAGACATCA CAGGGAGTGT GACACTTAAG 
CCCTGGTCCC CTGGCCTCTC TTCGTCCTCA TCCTCTGACA GCGTGTGGCC TTTGGGAAAG 
CCGGAAGGCC TCCTGGCTCG GGGCTGTGGC CTGGACTTCC TCAACAGGTC TCTGGCTATT 
CGGGTGTCTG GCCGGAGCCC CCCAGGGGGC CCAGAGCCGC AGGACAAGGG ACCAGATGGA 
CTGTCGTTTT ATGGGGACAG ATGGTCTGGG GCTGTGGTGC GCAGGGTGCT GTCTGGGCCT 
GGGTCCGCCA GGATGGAACC AAGAGAGCAA AGGGTGGAAG CTGCTGGTCT GGAGGGGGCG 
TGCCTGGAAG CCGAGGCCCA GCAGAGAACC TTGCTCTGGA ATCAGGGGTC CACACTCCCC 
TCCCTGATGG ACTCGAAGGC CTGCCAGTCC TTCCACGAGG CCCTAGAAGC CTGGGCAAAG 
GGACCAGGTG CCGAGCCCTT CTACATTCGT GCCAACCTCA CCTTGCCTGA GAGGGCAGAT 
CCCCATGCCC TTTGCGTGAA AGCCCAAGAG ATCCTTCGAC TGGTGGACTC GGCATACAAG 
CGGAGGCAGG AATGGTTCTG CACCCGGGTT GACCCCCTCA CTCTGCGGGA CCTGGACCGG 
GGCACCGTGC CCAATTATCA GAGAGCCCAG CAGCTCCTAG AAGTTCAGGA GAAATGCCTG 
CCCTCCAGCC GGCACCGAGG CCCCCGCAGT AATCTGAAGA AGAGAGCCCT GGACCAGCTG 
CGGCTGGTGA GGCCCAAGCC CGTGGGGGCG CCTGCAGGGG ACTCCCCGGA TCAGCTGCTG 
CTGGAGCCCT GTGCAGAGCC GGAGCGGAGC CTCAGACCCT ACAGTTTGGT GCGGCCGCTA 
CTGGTGTCTG CCCTGCGGCC CGTGGTGCTG TTGCCTGAGT GCCTGGCGCC CCGGCTCATC 
CGTAACCTGC TAGACCTGCC CAGCTCCCGG CTGGACTTCC AAGTGTGCCC AGCGGAAAGC 
CTCTCTGGGG AGGAACTGTG CCCATCCTCA GCGCCTGGAG CCCCCAAGGC TCAGCCTGCC 
ACCCCTGGGC TAGGCAGCAG GATCCGGGCC ATCCAGGAGT CTGTTGGGAA GAAGCACTGC 
CTGCTGGAGC TGGGTGCTCG GGGTGTGCGG GAGCTGGTGC AGAACGAGAT CTACCCCATC 
GTCATCCACG TGGAGGTGAC TGAGAAGAAT GTCCGGGAAG TCAGGGGTCT GCTGGGCCGG 
CCGGGCTGGC GGGACTCAGA GCTGCTGCGG CAGTGCCGTG GCTCAGAGCA GGTGCTCTGG 
GGGCTGCCCT GCTCCTGGGT GCAGGTGCCC GCCCATGAGT GGGGACACGC AGAGGAGCTG 
GCCAAGGTGG TGCGCGGCCG CATCCTGCAG GAGCAGGCCC GCCTCGTGTG GGTGGAGTGC 
GGCAGCAGCA GAGGCTGCCC CAGCAGCAGT GAGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055365.2
CDS	4..3102
Translation	MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVECGSSRGCPSSSEA

Target ORF information:

RefSeq Version	NM_014550.3
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase recruitment domain family member 10 (CARD10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014550.3

ORF Insert Sequence:

ATGCCGGGCC GGGCGGAGGC GGGGGAGGCC GAGGAGGAGG CCGGGGCCGG CTCGGGGTCT 
GAGGCGGAGG AGGACGCGCT GTGGGAGCGA ATCGAGGGCG TCCGGCATCG GCTGGCTCGC 
GCCCTGAACC CGGCCAAGCT CACGCCGTAT CTGCGCCAGT GCCGGGTCAT CGACGAGCAG 
GACGAGGAGG AGGTGCTGAG CACCTACCGC TTCCCGTGCC GCGTCAACCG CACCGGGCGC 
CTGATGGACA TCTTGCGCTG CCGTGGCAAG AGGGGCTATG AGGCCTTCCT GGAAGCCCTG 
GAGTTCTACT ACCCCGAACA CTTCACGCTG CTCACGGGCC AGGAACCCGC CCAGCGCTGC 
TCCATGATCC TCGATGAGGA GGGGCCTGAG GGCCTGACCC AATTCTTGAT GACAGAGGTG 
CGACGGCTGC GGGAAGCTCG CAAGAGCCAG CTGCAGCGGG AGCAGCAACT GCAGGCCCGG 
GGCCGGGTGC TCGAGGAGGA GCGGGCAGGG CTGGAGCAGC GGCTGCGGGA CCAGCAGCAG 
GCTCAGGAGC GCTGTCAACG GCTGCGGGAG GACTGGGAGG CGGGCAGCCT GGAGCTGCTG 
CGGCTCAAGG ATGAGAACTA CATGATCGCC ATGCGCCTGG CACAGCTCAG TGAGGAGAAG 
AACTCGGCTG TACTTCGCAG CCGTGACCTG CAGCTGGCGG TGGATCAGCT CAAGCTCAAA 
GTGAGTCGGC TGGAGGAAGA GTGTGCACTG CTTCGAAGGG CCAGGGGCCC GCCCCCTGGG 
GCAGAGGAGA AGGAGAAGGA GAAGGAGAAG GAGAAGGAGC CAGACAATGT GGACCTTGTC 
TCTGAGCTGC GTGCTGAGAA CCAGCGGCTG ACGGCGTCAC TGCGGGAGTT GCAGGAGGGC 
CTGCAGCAGG AGGCGAGCCG GCCGGGGGCC CCGGGCTCCG AGCGCATCCT GCTGGACATC 
CTAGAGCATG ACTGGCGGGA GGCGCAGGAC AGCAGGCAGG AGCTGTGCCA GAAGCTGCAT 
GCCGTGCAGG GGGAGCTGCA GTGGGCCGAG GAGCTGCGCG ACCAGTACCT GCAGGAGATG 
GAAGACCTGC GGCTCAAGCA CCGCACGCTG CAGAAGGACT GTGACCTGTA CAAGCACCGC 
ATGGCCACTG TCCTGGCCCA ACTGGAGGAG ATTGAGAAGG AGCGAGACCA GGCCATCCAG 
AGCCGTGACC GGATCCAGTT GCAGTACTCA CAGAGCCTCA TCGAGAAGGA CCAGTACCGC 
AAGCAGGTGC GGGGCCTGGA GGCGGAGCGG GATGAGCTGC TGACAACGCT CACCAGCCTG 
GAGGGCACCA AGGCTCTGCT GGAGGTTCAG CTGCAGCGGG CCCAGGGTGG CACCTGCCTC 
AAGGCCTGTG CCTCCTCCCA TTCCCTGTGC TCCAACCTCA GCAGCACTTG GAGCCTGAGC 
GAGTTCCCCT CCCCTCTGGG AGGCCCAGAA GCAACTGGGG AGGCAGCTGT CATGGGGGGA 
CCTGAGCCTC ACAACTCGGA GGAAGCCACA GACAGTGAAA AGGAGATCAA TCGGCTCTCC 
ATCCTGCCCT TCCCCCCCAG TGCCGGCTCC ATCCTCCGCC GGCAGCGTGA GGAAGACCCC 
GCACCCCCTA AGAGATCCTT CAGCAGCATG TCAGACATCA CAGGGAGTGT GACACTTAAG 
CCCTGGTCCC CTGGCCTCTC TTCGTCCTCA TCCTCTGACA GCGTGTGGCC TTTGGGAAAG 
CCGGAAGGCC TCCTGGCTCG GGGCTGTGGC CTGGACTTCC TCAACAGGTC TCTGGCTATT 
CGGGTGTCTG GCCGGAGCCC CCCAGGGGGC CCAGAGCCGC AGGACAAGGG ACCAGATGGA 
CTGTCGTTTT ATGGGGACAG ATGGTCTGGG GCTGTGGTGC GCAGGGTGCT GTCTGGGCCT 
GGGTCCGCCA GGATGGAACC AAGAGAGCAA AGGGTGGAAG CTGCTGGTCT GGAGGGGGCG 
TGCCTGGAAG CCGAGGCCCA GCAGAGAACC TTGCTCTGGA ATCAGGGGTC CACACTCCCC 
TCCCTGATGG ACTCGAAGGC CTGCCAGTCC TTCCACGAGG CCCTAGAAGC CTGGGCAAAG 
GGACCAGGTG CCGAGCCCTT CTACATTCGT GCCAACCTCA CCTTGCCTGA GAGGGCAGAT 
CCCCATGCCC TTTGCGTGAA AGCCCAAGAG ATCCTTCGAC TGGTGGACTC GGCATACAAG 
CGGAGGCAGG AATGGTTCTG CACCCGGGTT GACCCCCTCA CTCTGCGGGA CCTGGACCGG 
GGCACCGTGC CCAATTATCA GAGAGCCCAG CAGCTCCTAG AAGTTCAGGA GAAATGCCTG 
CCCTCCAGCC GGCACCGAGG CCCCCGCAGT AATCTGAAGA AGAGAGCCCT GGACCAGCTG 
CGGCTGGTGA GGCCCAAGCC CGTGGGGGCG CCTGCAGGGG ACTCCCCGGA TCAGCTGCTG 
CTGGAGCCCT GTGCAGAGCC GGAGCGGAGC CTCAGACCCT ACAGTTTGGT GCGGCCGCTA 
CTGGTGTCTG CCCTGCGGCC CGTGGTGCTG TTGCCTGAGT GCCTGGCGCC CCGGCTCATC 
CGTAACCTGC TAGACCTGCC CAGCTCCCGG CTGGACTTCC AAGTGTGCCC AGCGGAAAGC 
CTCTCTGGGG AGGAACTGTG CCCATCCTCA GCGCCTGGAG CCCCCAAGGC TCAGCCTGCC 
ACCCCTGGGC TAGGCAGCAG GATCCGGGCC ATCCAGGAGT CTGTTGGGAA GAAGCACTGC 
CTGCTGGAGC TGGGTGCTCG GGGTGTGCGG GAGCTGGTGC AGAACGAGAT CTACCCCATC 
GTCATCCACG TGGAGGTGAC TGAGAAGAAT GTCCGGGAAG TCAGGGGTCT GCTGGGCCGG 
CCGGGCTGGC GGGACTCAGA GCTGCTGCGG CAGTGCCGTG GCTCAGAGCA GGTGCTCTGG 
GGGCTGCCCT GCTCCTGGGT GCAGGTGCCC GCCCATGAGT GGGGACACGC AGAGGAGCTG 
GCCAAGGTGG TGCGCGGCCG CATCCTGCAG GAGCAGGCCC GCCTCGTGTG GGTGGAGTGC 
GGCAGCAGCA GAGGCTGCCC CAGCAGCAGT GAGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The CARMA3-Bcl10-MALT1 Signalosome Drives NF-?B Activation and Promotes Aggressiveness in Angiotensin II Receptor-positive Breast Cancer.
Cancer research(2017 Dec)
Ekambaram P,Lee JL,Hubel NE,Hu D,Yerneni S,Campbell PG,Pollock N,Klei LR,Concel VJ,Delekta PC,Chinnaiyan AM,Tomlins SA,Rhodes DR,Priedigkeit N,Lee AV,Oesterreich S,McAllister-Lucas L,Lucas PC

The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-?B activation and cell survival.
Protein & cell8(11)856-860(2017 11)
Zhang S,Pan D,Jia XM,Lin X,Zhao X

Lack of association between CARD10/CARMA3 tag SNPs and psoriasis vulgaris in the southern Chinese population.
Genetics and molecular research : GMR16(1)(2017 Mar)
Shi G,Zhang MF,Liao PY,Wang TT,Li SJ,Fan YM,Zhu KJ

Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population.
BMC research notes8777(2015 Dec)
Migita K,Jiuchi Y,Furukawa H,Nakamura M,Komori A,Yasunami M,Kozuru H,Abiru S,Yamasaki K,Nagaoka S,Hashimoto S,Bekki S,Yoshizawa K,Shimada M,Kouno H,Kamitsukasa H,Komatsu T,Hijioka T,Nakamuta M,Naganuma A,Yamashita H,Nishimura H,Ohta H,Nakamura Y,Ario K,Oohara Y,Sugi K,Tomizawa M,Sato T,Takahashi H,Muro T,Makita F,Mita E,Sakai H,Yatsuhashi H

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CARD10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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