GTF2A2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GTF2A2
Entrez Gene ID	2958
Full Name	general transcription factor IIA subunit 2
Synonyms	HsT18745,T18745,TF2A2,TFIIA,TFIIA-12,TFIIA-gamma,TFIIAS
General protein information	Preferred Names general transcription factor IIA subunit 2 Names transcription initiation factor IIA subunit 2 TFIIA gamma subunit TFIIA p12 subunit general transcription factor IIA 2 general transcription factor IIA, 2, 12kDa transcription initiation factor IIA gamma chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q22.2
Summary	Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008].
Disorder MIM:	600519

mRNA and Protein(s)

mRNA	Protein	Name
NM_004492.2	NP_004483.1	transcription initiation factor IIA subunit 2
NM_001320930.1	NP_001307859.1	transcription initiation factor IIA subunit 2
NM_001320929.2	NP_001307858.1	transcription initiation factor IIA subunit 2
NM_001320929.1	NP_001307858.1	transcription initiation factor IIA subunit 2
NM_004492.3	NP_004483.1	transcription initiation factor IIA subunit 2
XM_005254324.2	XP_005254381.1	transcription initiation factor IIA subunit 2 isoform X1
XM_005254325.2	XP_005254382.1	transcription initiation factor IIA subunit 2 isoform X1
NM_001320930.2	NP_001307859.1	transcription initiation factor IIA subunit 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GTF2A2	NP_001032708.1
Mus musculus (house mouse)	Gtf2a2	NP_001034608.1
Drosophila melanogaster (fruit fly)	TfIIA-S	NP_524467.1
Eremothecium gossypii	AGOS_ABR071W	NP_983017.2
Oryza sativa (rice)	Os05g0107700	NP_001054426.1
	GTF2A2	XP_001100320.1
Canis lupus familiaris (dog)	GTF2A2	XP_005638528.1
Gallus gallus (chicken)	GTF2A2	NP_001075177.1
Saccharomyces cerevisiae (baker's yeast)	TOA2	NP_012865.1
Oryza sativa (rice)	Os01g0970500	NP_001045526.1
Kluyveromyces lactis	KLLA0C12815g	XP_452771.1
Magnaporthe oryzae (rice blast fungus)	MGG_06107	XP_003711973.1
Neurospora crassa	NCU09748	XP_964450.1
Xenopus tropicalis (tropical clawed frog)	gtf2a2	NP_001005107.1
Homo sapiens (human)	GTF2A2	NP_004483.1
Pan troglodytes (chimpanzee)	GTF2A2	XP_001173111.1
Rattus norvegicus (Norway rat)	Gtf2a2	NP_445797.1
Danio rerio (zebrafish)	gtf2a2	NP_001018441.1
Caenorhabditis elegans (roundworm)	CELE_Y111B2A.13	NP_499644.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004370	XP_313653.4
Schizosaccharomyces pombe (fission yeast)	SPCC553.11c	NP_587763.2
Arabidopsis thaliana (thale cress)	AT4G24440	NP_194175.1

Gene Ontology
Bibliography

Related articles in PubMed

A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.
Wang J, Zhao S, He W, Wei Y, Zhang Y, Pegg H, Shore P, Roberts SGE, Deng W
The Journal of biological chemistry292(28)11873-11885(2017 07)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Near-atomic resolution visualization of human transcription promoter opening.
He Y, Yan C, Fang J, Inouye C, Tjian R, Ivanov I, Nogales E
Nature533(7603)359-65(2016 05)

Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, Byun SS, Yang JO, Kim JH, Kim DG, Yeom YI, Yoo HS, Kim YS, Kim NS
Biochemical and biophysical research communications345(3)1022-32(2006 Jul)

Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF).
Nakadai T, Shimada M, Shima D, Handa H, Tamura TA
The Journal of biological chemistry279(9)7447-55(2004 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that many TATA-box-containing promoters contain a TFIIA recognition element (IIARE) that activates transcription by increasing the recruitment of RNA polymerase II, TFIIA (TF2A1/TF2A2 subunits), TAF4, and P300. (TAF4 = TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1; P300 = E1A binding protein p300)
Title: A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.

transcription factor IIA may regulate the intracellular molecular state and the function of TATA-binding protein-like protein (TLP) through its property of binding to TLP
Title: Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF).

The following GTF2A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GTF2A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04402	NM_001320930.2 Latest version!	Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04402	NM_004492.3 Latest version!	Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04402	NM_001320929.2 Latest version!	Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04402	XM_005254325.2 Latest version!	Homo sapiens general transcription factor IIA, 2, 12kDa (GTF2A2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04402	XM_005254324.2 Latest version!	Homo sapiens general transcription factor IIA, 2, 12kDa (GTF2A2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu04402	NM_001320929.1	Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04402	NM_004492.2	Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04402	NM_001320930.1	Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GTF2A2 ( NM_004492.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004483.1 Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04402
Clone ID Related Accession (Same CDS sequence)	NM_004492.2 , NM_001320930.1 , NM_001320929.2 , NM_001320929.1 , NM_004492.3 , XM_005254324.2 , XM_005254325.2 , NM_001320930.2
Accession Version	NM_004492.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	transcription initiation factor IIA subunit 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK312015.1, BC000287.2, CV572751.1 and DB531003.1. On Jan 8, 2009 this sequence version replaced NM_004492.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA923205.1, SRR1660803.290032.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267760, SAMN03267776 [ECO:0000348] ##Evidence-Data-END##

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004483.1
CDS	183..512
Translation	MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE

Target ORF information:

RefSeq Version	NM_004492.2
Organism	Homo sapiens(human)
Definition	Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004492.2

ORF Insert Sequence:

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GTF2A2 ( NM_001320930.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307859.1 Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu04402
Clone ID Related Accession (Same CDS sequence)	NM_004492.2 , NM_001320930.1 , NM_001320929.2 , NM_001320929.1 , NM_004492.3 , XM_005254324.2 , XM_005254325.2 , NM_001320930.2
Accession Version	NM_001320930.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-22
Organism	Homo sapiens(human)
Product	transcription initiation factor IIA subunit 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092755.4, CB156109.1 and BX099306.1. On Mar 12, 2016 this sequence version replaced XM_005254324.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.288616.1, SRR1163657.160216.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307859.1
CDS	405..734
Translation	MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE

Target ORF information:

RefSeq Version	NM_001320930.1
Organism	Homo sapiens(human)
Definition	Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320930.1

ORF Insert Sequence:

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GTF2A2 ( NM_001320929.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307858.1 Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04402
Clone ID Related Accession (Same CDS sequence)	NM_004492.2 , NM_001320930.1 , NM_001320929.2 , NM_001320929.1 , NM_004492.3 , XM_005254324.2 , XM_005254325.2 , NM_001320930.2
Accession Version	NM_001320929.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	transcription initiation factor IIA subunit 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092755.4, HY036972.1, HY002503.1 and BX099306.1. On May 31, 2019 this sequence version replaced NM_001320929.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.55776.1, SRR1163657.324612.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307858.1
CDS	232..561
Translation	MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE

Target ORF information:

RefSeq Version	NM_001320929.2
Organism	Homo sapiens(human)
Definition	Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320929.2

ORF Insert Sequence:

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GTF2A2 ( NM_001320929.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307858.1 Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04402
Clone ID Related Accession (Same CDS sequence)	NM_004492.2 , NM_001320930.1 , NM_001320929.2 , NM_001320929.1 , NM_004492.3 , XM_005254324.2 , XM_005254325.2 , NM_001320930.2
Accession Version	NM_001320929.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-22
Organism	Homo sapiens(human)
Product	transcription initiation factor IIA subunit 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY036972.1, AC092755.4, HY002503.1 and BX099306.1. On Mar 10, 2016 this sequence version replaced XM_005254325.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HY036972.1, SRR1163655.55776.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307858.1
CDS	181..510
Translation	MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE

Target ORF information:

RefSeq Version	NM_001320929.1
Organism	Homo sapiens(human)
Definition	Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320929.1

ORF Insert Sequence:

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GTF2A2 ( NM_004492.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004483.1 Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04402
Clone ID Related Accession (Same CDS sequence)	NM_004492.2 , NM_001320930.1 , NM_001320929.2 , NM_001320929.1 , NM_004492.3 , XM_005254324.2 , XM_005254325.2 , NM_001320930.2
Accession Version	NM_004492.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	transcription initiation factor IIA subunit 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK312015.1, BC000287.2, CV572751.1 and DB531003.1. On Nov 22, 2018 this sequence version replaced NM_004492.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.73923.1, SRR5189658.92639.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267760, SAMN03267776 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000396060.7/ ENSP00000379372.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004483.1
CDS	160..489
Translation	MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE

Target ORF information:

RefSeq Version	NM_004492.3
Organism	Homo sapiens(human)
Definition	Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004492.3

ORF Insert Sequence:

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GTF2A2 ( NM_001320930.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307859.1 Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu04402
Clone ID Related Accession (Same CDS sequence)	NM_004492.2 , NM_001320930.1 , NM_001320929.2 , NM_001320929.1 , NM_004492.3 , XM_005254324.2 , XM_005254325.2 , NM_001320930.2
Accession Version	NM_001320930.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	transcription initiation factor IIA subunit 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092755.4, CB156109.1 and BX099306.1. On May 31, 2019 this sequence version replaced NM_001320930.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.288616.1, SRR5189667.319416.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307859.1
CDS	379..708
Translation	MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE

Target ORF information:

RefSeq Version	NM_001320930.2
Organism	Homo sapiens(human)
Definition	Homo sapiens general transcription factor IIA subunit 2 (GTF2A2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320930.2

ORF Insert Sequence:

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GTF2A2 ( XM_005254324.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005254381.1 Homo sapiens general transcription factor IIA, 2, 12kDa (GTF2A2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu04402
Clone ID Related Accession (Same CDS sequence)	NM_004492.2 , NM_001320930.1 , NM_001320929.2 , NM_001320929.1 , NM_004492.3 , XM_005254324.2 , XM_005254325.2 , NM_001320930.2
Accession Version	XM_005254324.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	transcription initiation factor IIA subunit 2 isoform X1
Comment

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005254381.1
Translation	MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE

Target ORF information:

RefSeq Version	XM_005254324.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens general transcription factor IIA, 2, 12kDa (GTF2A2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005254324.2

ORF Insert Sequence:

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GTF2A2 ( XM_005254325.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005254382.1 Homo sapiens general transcription factor IIA, 2, 12kDa (GTF2A2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu04402
Clone ID Related Accession (Same CDS sequence)	NM_004492.2 , NM_001320930.1 , NM_001320929.2 , NM_001320929.1 , NM_004492.3 , XM_005254324.2 , XM_005254325.2 , NM_001320930.2
Accession Version	XM_005254325.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	transcription initiation factor IIA subunit 2 isoform X1
Comment

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005254382.1
Translation	MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE

Target ORF information:

RefSeq Version	XM_005254325.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens general transcription factor IIA, 2, 12kDa (GTF2A2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005254325.2

ORF Insert Sequence:

ATGGCATATC AGTTATACAG AAATACTACT TTGGGAAACA GTCTTCAGGA GAGCCTAGAT 
GAGCTCATAC AGTCTCAACA GATCACCCCC CAACTTGCCC TTCAAGTTCT ACTTCAGTTT 
GATAAGGCTA TAAATGCAGC ACTGGCTCAG AGGGTCAGGA ACAGAGTCAA TTTCAGGGGC 
TCTCTAAATA CGTACAGATT CTGCGATAAT GTGTGGACTT TTGTACTGAA TGATGTTGAA 
TTCAGAGAGG TGACAGAACT TATTAAAGTG GATAAAGTGA AAATTGTAGC CTGTGATGGT 
AAAAATACTG GCTCCAATAC TACAGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.
The Journal of biological chemistry292(28)11873-11885(2017 07)
Wang J,Zhao S,He W,Wei Y,Zhang Y,Pegg H,Shore P,Roberts SGE,Deng W

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Near-atomic resolution visualization of human transcription promoter opening.
Nature533(7603)359-65(2016 05)
He Y,Yan C,Fang J,Inouye C,Tjian R,Ivanov I,Nogales E

Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Biochemical and biophysical research communications345(3)1022-32(2006 Jul)
Wang AG,Yoon SY,Oh JH,Jeon YJ,Kim M,Kim JM,Byun SS,Yang JO,Kim JH,Kim DG,Yeom YI,Yoo HS,Kim YS,Kim NS

Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF).
The Journal of biological chemistry279(9)7447-55(2004 Feb)
Nakadai T,Shimada M,Shima D,Handa H,Tamura TA

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GTF2A2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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