CXCL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXCL2
Entrez Gene ID	2920
Full Name	C-X-C motif chemokine ligand 2
Synonyms	CINC-2a,GRO2,GROb,MGSA-b,MIP-2a,MIP2,MIP2A,SCYB2
General protein information	Preferred Names C-X-C motif chemokine ligand 2 Names C-X-C motif chemokine 2 GRO2 oncogene MGSA beta MIP2-alpha chemokine (C-X-C motif) ligand 2 gro-beta growth-regulated protein beta macrophage inflammatory protein 2-alpha melanoma growth stimulatory activity beta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.3
Summary	This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014].
Disorder MIM:	139110

mRNA and Protein(s)

mRNA	Protein	Name
NM_002089.4	NP_002080.1	C-X-C motif chemokine 2 precursor
NM_002089.3	NP_002080.1	C-X-C motif chemokine 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CXCL2	XP_001155614.1
Bos taurus (cattle)	CXCL2	NP_776724.1
Bos taurus (cattle)	CXCL3	NP_001039978.1
Bos taurus (cattle)	GRO1	NP_783631.1
Homo sapiens (human)	CXCL2	NP_002080.1
	CXCL2	XP_001092240.1
Mus musculus (house mouse)	Cxcl1	NP_032202.1
Rattus norvegicus (Norway rat)	Cxcl1	NP_110472.1

Gene Ontology
Bibliography

Related articles in PubMed

CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer.
Zhang H, Ye YL, Li MX, Ye SB, Huang WR, Cai TT, He J, Peng JY, Duan TH, Cui J, Zhang XS, Zhou FJ, Wang RF, Li J
Oncogene36(15)2095-2104(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results identify the CXCL2/MIF-CXCR2 axis as an important mediator in MDSC recruitment and as predictors in bladder cancer.
Title: CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer.

Chronic inflammation contributes to the change of CXCL12 DNA methylation in buccal cells and that DNA methylation profile of CXCL12 promoter plays important role in development and progression of periodontal disease.
Title: Association of CXCL12 gene promoter methylation with periodontitis in patients with diabetes mellitus type 2.

Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci
Title: Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci.

Functional effects data suggested that recombinant human CXCL2 significantly enhanced the migration, invasion ability of SMMC7721 hepatocellular carcinoma cells, and weakened adhesion ability.
Title: Type conversion of secretomes in a 3D TAM2 and HCC cell co-culture system and functional importance of CXCL2 in HCC.

Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population
Title: Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population.

The following CXCL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03826	NM_002089.4 Latest version!	Homo sapiens C-X-C motif chemokine ligand 2 (CXCL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu03826	NM_002089.3	Homo sapiens C-X-C motif chemokine ligand 2 (CXCL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXCL2 ( NM_002089.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002080.1 Homo sapiens C-X-C motif chemokine ligand 2 (CXCL2), mRNA.

Price & Availability↑

CloneID	OHu03826
Clone ID Related Accession (Same CDS sequence)	NM_002089.4 , NM_002089.3
Accession Version	NM_002089.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	C-X-C motif chemokine 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX334969.2, X53799.1 and BC053653.1. On Nov 23, 2018 this sequence version replaced NM_002089.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015753.1, SRR5189664.118449.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000508487.3/ ENSP00000427279.1 Protein has antimicrobial activity :: PMID: 10725737, 12949249 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCGCG CCACGCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG GGTGGCGCTG 
CTGCTCCTGC TCCTGGTGGC CGCCAGCCGG CGCGCAGCAG GAGCGCCCCT GGCCACTGAA 
CTGCGCTGCC AGTGCTTGCA GACCCTGCAG GGAATTCACC TCAAGAACAT CCAAAGTGTG 
AAGGTGAAGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT 
GGGCAGAAAG CTTGTCTCAA CCCCGCATCG CCCATGGTTA AGAAAATCAT CGAAAAGATG 
CTGAAAAATG GCAAATCCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002080.1
CDS	76..399
Translation	MARATLSAAPSNPRLLRVALLLLLLVAASRRAAGAPLATELRCQCLQTLQGIHLKNIQSVKVKSPGPHCAQTEVIATLKNGQKACLNPASPMVKKIIEKMLKNGKSN

Target ORF information:

RefSeq Version	NM_002089.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C-X-C motif chemokine ligand 2 (CXCL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002089.4

ORF Insert Sequence:

ATGGCCCGCG CCACGCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG GGTGGCGCTG 
CTGCTCCTGC TCCTGGTGGC CGCCAGCCGG CGCGCAGCAG GAGCGCCCCT GGCCACTGAA 
CTGCGCTGCC AGTGCTTGCA GACCCTGCAG GGAATTCACC TCAAGAACAT CCAAAGTGTG 
AAGGTGAAGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT 
GGGCAGAAAG CTTGTCTCAA CCCCGCATCG CCCATGGTTA AGAAAATCAT CGAAAAGATG 
CTGAAAAATG GCAAATCCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CXCL2 ( NM_002089.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002080.1 Homo sapiens C-X-C motif chemokine ligand 2 (CXCL2), mRNA.

Price & Availability↑

CloneID	OHu03826
Clone ID Related Accession (Same CDS sequence)	NM_002089.4 , NM_002089.3
Accession Version	NM_002089.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-05-06
Organism	Homo sapiens(human)
Product	C-X-C motif chemokine 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX334969.2, X53799.1 and BC053653.1. On May 25, 2007 this sequence version replaced NM_002089.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX395968.2, BX334969.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 10725737, 12949249 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCGCG CCACGCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG GGTGGCGCTG 
CTGCTCCTGC TCCTGGTGGC CGCCAGCCGG CGCGCAGCAG GAGCGCCCCT GGCCACTGAA 
CTGCGCTGCC AGTGCTTGCA GACCCTGCAG GGAATTCACC TCAAGAACAT CCAAAGTGTG 
AAGGTGAAGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT 
GGGCAGAAAG CTTGTCTCAA CCCCGCATCG CCCATGGTTA AGAAAATCAT CGAAAAGATG 
CTGAAAAATG GCAAATCCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002080.1
CDS	161..484
Translation	MARATLSAAPSNPRLLRVALLLLLLVAASRRAAGAPLATELRCQCLQTLQGIHLKNIQSVKVKSPGPHCAQTEVIATLKNGQKACLNPASPMVKKIIEKMLKNGKSN

Target ORF information:

RefSeq Version	NM_002089.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-X-C motif chemokine ligand 2 (CXCL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002089.3

ORF Insert Sequence:

ATGGCCCGCG CCACGCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG GGTGGCGCTG 
CTGCTCCTGC TCCTGGTGGC CGCCAGCCGG CGCGCAGCAG GAGCGCCCCT GGCCACTGAA 
CTGCGCTGCC AGTGCTTGCA GACCCTGCAG GGAATTCACC TCAAGAACAT CCAAAGTGTG 
AAGGTGAAGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT 
GGGCAGAAAG CTTGTCTCAA CCCCGCATCG CCCATGGTTA AGAAAATCAT CGAAAAGATG 
CTGAAAAATG GCAAATCCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer.
Oncogene36(15)2095-2104(2017 Apr)
Zhang H,Ye YL,Li MX,Ye SB,Huang WR,Cai TT,He J,Peng JY,Duan TH,Cui J,Zhang XS,Zhou FJ,Wang RF,Li J

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CXCL2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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