MYLIP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MYLIP
Entrez Gene ID	29116
Full Name	myosin regulatory light chain interacting protein
Synonyms	IDOL,MIR
General protein information	Preferred Names myosin regulatory light chain interacting protein Names E3 ubiquitin-protein ligase MYLIP E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor RING-type E3 ubiquitin transferase MYLIP band 4.1 superfamily member BZF1 cellular modulator of immune recognition (c-MIR) inducible degrader of the LDL-receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.3
Summary	The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008].
Disorder MIM:	610082

mRNA and Protein(s)

mRNA	Protein	Name
XM_017010789.1	XP_016866278.1	E3 ubiquitin-protein ligase MYLIP isoform X1
XM_005249032.2	XP_005249089.1	E3 ubiquitin-protein ligase MYLIP isoform X2
NM_013262.3	NP_037394.2	E3 ubiquitin-protein ligase MYLIP
XM_005249033.3	XP_005249090.1	E3 ubiquitin-protein ligase MYLIP isoform X3
NM_013262.4	NP_037394.2	E3 ubiquitin-protein ligase MYLIP
XM_005249033.2	XP_005249090.1	E3 ubiquitin-protein ligase MYLIP isoform X3

Pathways from BioSystems

Homologies

Homo sapiens (human)	MYLIP	NP_037394.2
Bos taurus (cattle)	MYLIP	NP_001095723.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001609	XP_551203.4
Danio rerio (zebrafish)	mylipa	NP_956277.1
Xenopus tropicalis (tropical clawed frog)	mylip	NP_001017059.2
Mus musculus (house mouse)	Mylip	NP_722484.2
Gallus gallus (chicken)	MYLIP	NP_001012579.1
Drosophila melanogaster (fruit fly)	dnr1	NP_611680.2
Canis lupus familiaris (dog)	MYLIP	XP_545352.3
Pan troglodytes (chimpanzee)	MYLIP	XP_518252.2
	MYLIP	XP_001094408.1
Rattus norvegicus (Norway rat)	Mylip	NP_001100814.2

Gene Ontology
Bibliography

Related articles in PubMed

RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol.
Mitchel K, Theusch E, Cubitt C, Dos? AC, Stevens K, Naidoo D, Medina MW
Circulation. Cardiovascular genetics9(3)223-30(2016 Jun)

Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol.
Ibrahim S, Somanathan S, Billheimer J, Wilson JM, Rader DJ
Cardiovascular research110(1)23-9(2016 May)

The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.
Nelson JK, Sorrentino V, Avagliano Trezza R, Heride C, Urbe S, Distel B, Zelcer N
Circulation research118(3)410-9(2016 Feb)

Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.
Nelson JK, Cook EC, Loregger A, Hoeksema MA, Scheij S, Kovacevic I, Hordijk PL, Ovaa H, Zelcer N
The Journal of biological chemistry291(9)4813-25(2016 Feb)

IDOL, inducible degrader of low-density lipoprotein receptor, serves as a potential therapeutic target for dyslipidemia.
Zhang CP, Tian Y, Zhang M, Tuo QH, Chen JX, Liao DF
Medical hypotheses86138-42(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The long noncoding RNA RP1-13D10.2 may contribute to LDL cholesterol levels in response to statins.
Title: RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol.

the effects caused by human inducible degrader of the low-density lipoprotein expression are LDLR- dependent given the unchanged plasma lipids in LAhB mice lacking low-density lipoprotein receptor
Title: Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol.

Identify USP2 as a novel regulator of lipoprotein clearance owing to its ability to control ubiquitylation-dependent degradation of the LDLR by IDOL.
Title: The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.

Data suggest inducible expression of IDOL is subject to robust, rapid regulation by process that is sensitive to deubiquitinase inhibition in human/mouse cell lines and primary human cells; transcriptional induction of IDOL leads to degradation of LDLR.
Title: Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.

Specifically, loss of IDOL increases LDLR distribution in the hepatic cell, and subsequently reduces serum LDL-C levels in dyslipidemic patients
Title: IDOL, inducible degrader of low-density lipoprotein receptor, serves as a potential therapeutic target for dyslipidemia.

The following MYLIP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYLIP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24766	NM_013262.4 Latest version!	Homo sapiens myosin regulatory light chain interacting protein (MYLIP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu40275	XM_005249033.3 Latest version!	Homo sapiens myosin regulatory light chain interacting protein (MYLIP), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu40274	XM_005249032.2 Latest version!	Homo sapiens myosin regulatory light chain interacting protein (MYLIP), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu96563	XM_017010789.1 Latest version!	Homo sapiens myosin regulatory light chain interacting protein (MYLIP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu24766	NM_013262.3	Homo sapiens myosin regulatory light chain interacting protein (MYLIP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu40275	XM_005249033.2	Homo sapiens myosin regulatory light chain interacting protein (MYLIP), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYLIP ( NM_013262.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037394.2 Homo sapiens myosin regulatory light chain interacting protein (MYLIP), mRNA.

Price & Availability↑

CloneID	OHu24766
Clone ID Related Accession (Same CDS sequence)	NM_013262.3 , NM_013262.4
Accession Version	NM_013262.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase MYLIP
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK074391.1, AK026739.1 and AF212221.1. On Dec 5, 2003 this sequence version replaced NM_013262.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK074391.1, SRR1803616.246318.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGTGTT ATGTGACGAG GCCGGACGCG GTGCTGATGG AGGTGGAGGT GGAGGCGAAA 
GCCAACGGCG AGGACTGCCT CAACCAGGTG TGCAGGCGAC TGGGAATCAT AGAAGTTGAC 
TATTTTGGAC TGCAGTTTAC GGGTAGCAAA GGTGAAAGTT TATGGCTAAA CCTGAGAAAC 
CGGATCTCCC AGCAGATGGA TGGGCTAGCC CCTTACAGGC TTAAACTTAG AGTCAAGTTC 
TTCGTGGAGC CTCATCTCAT CTTACAGGAG CAGACTAGGC ATATCTTTTT CTTGCACATC 
AAGGAGGCCC TCTTGGCAGG CCACCTCTTG TGTTCCCCAG AGCAGGCAGT GGAACTCAGT 
GCCCTCCTGG CCCAGACCAA GTTTGGAGAC TACAACCAGA ACACTGCCAA GTATAACTAT 
GAGGAGCTCT GTGCCAAGGA GCTCTCCTCT GCCACCTTGA ACAGCATTGT TGCAAAACAT 
AAGGAGTTGG AGGGGACCAG CCAGGCTTCA GCTGAATACC AAGTTTTGCA GATTGTGTCG 
GCAATGGAAA ACTATGGCAT AGAATGGCAT TCTGTGCGGG ATAGCGAAGG GCAGAAACTG 
CTCATTGGGG TTGGACCTGA AGGAATCTCA ATTTGTAAAG ATGACTTTAG CCCAATTAAT 
AGGATAGCTT ATCCTGTGGT GCAGATGGCC ACCCAGTCAG GAAAGAATGT ATATTTGACG 
GTCACCAAGG AATCTGGGAA CAGCATCGTG CTCTTGTTTA AAATGATCAG CACCAGGGCG 
GCCAGCGGGC TCTACCGAGC GATAACAGAG ACGCACGCAT TCTACAGGTG TGACACAGTG 
ACCAGCGCCG TGATGATGCA GTATAGCCGT GACTTGAAGG GCCACTTGGC ATCTCTGTTT 
CTGAATGAAA ACATTAACCT TGGCAAGAAA TATGTCTTTG ATATTAAAAG AACATCAAAG 
GAGGTGTATG ACCATGCCAG GAGGGCTCTG TACAATGCTG GCGTTGTGGA CCTCGTTTCA 
AGAAACAACC AGAGCCCTTC ACACTCGCCT CTGAAGTCCT CAGAAAGCAG CATGAACTGC 
AGCAGCTGCG AGGGCCTCAG CTGCCAGCAG ACCCGGGTGC TGCAGGAGAA GCTACGCAAG 
CTGAAGGAAG CCATGCTGTG CATGGTGTGC TGCGAGGAGG AGATCAACTC CACCTTCTGT 
CCCTGTGGCC ACACTGTGTG CTGTGAGAGC TGCGCCGCCC AGCTACAGTC ATGTCCCGTC 
TGCAGGTCGC GTGTGGAGCA TGTCCAGCAC GTCTATCTGC CAACGCACAC CAGTCTTCTC 
AATCTGACTG TAATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037394.2
CDS	238..1575
Translation	MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI

Target ORF information:

RefSeq Version	NM_013262.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin regulatory light chain interacting protein (MYLIP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013262.3

ORF Insert Sequence:

ATGCTGTGTT ATGTGACGAG GCCGGACGCG GTGCTGATGG AGGTGGAGGT GGAGGCGAAA 
GCCAACGGCG AGGACTGCCT CAACCAGGTG TGCAGGCGAC TGGGAATCAT AGAAGTTGAC 
TATTTTGGAC TGCAGTTTAC GGGTAGCAAA GGTGAAAGTT TATGGCTAAA CCTGAGAAAC 
CGGATCTCCC AGCAGATGGA TGGGCTAGCC CCTTACAGGC TTAAACTTAG AGTCAAGTTC 
TTCGTGGAGC CTCATCTCAT CTTACAGGAG CAGACTAGGC ATATCTTTTT CTTGCACATC 
AAGGAGGCCC TCTTGGCAGG CCACCTCTTG TGTTCCCCAG AGCAGGCAGT GGAACTCAGT 
GCCCTCCTGG CCCAGACCAA GTTTGGAGAC TACAACCAGA ACACTGCCAA GTATAACTAT 
GAGGAGCTCT GTGCCAAGGA GCTCTCCTCT GCCACCTTGA ACAGCATTGT TGCAAAACAT 
AAGGAGTTGG AGGGGACCAG CCAGGCTTCA GCTGAATACC AAGTTTTGCA GATTGTGTCG 
GCAATGGAAA ACTATGGCAT AGAATGGCAT TCTGTGCGGG ATAGCGAAGG GCAGAAACTG 
CTCATTGGGG TTGGACCTGA AGGAATCTCA ATTTGTAAAG ATGACTTTAG CCCAATTAAT 
AGGATAGCTT ATCCTGTGGT GCAGATGGCC ACCCAGTCAG GAAAGAATGT ATATTTGACG 
GTCACCAAGG AATCTGGGAA CAGCATCGTG CTCTTGTTTA AAATGATCAG CACCAGGGCG 
GCCAGCGGGC TCTACCGAGC GATAACAGAG ACGCACGCAT TCTACAGGTG TGACACAGTG 
ACCAGCGCCG TGATGATGCA GTATAGCCGT GACTTGAAGG GCCACTTGGC ATCTCTGTTT 
CTGAATGAAA ACATTAACCT TGGCAAGAAA TATGTCTTTG ATATTAAAAG AACATCAAAG 
GAGGTGTATG ACCATGCCAG GAGGGCTCTG TACAATGCTG GCGTTGTGGA CCTCGTTTCA 
AGAAACAACC AGAGCCCTTC ACACTCGCCT CTGAAGTCCT CAGAAAGCAG CATGAACTGC 
AGCAGCTGCG AGGGCCTCAG CTGCCAGCAG ACCCGGGTGC TGCAGGAGAA GCTACGCAAG 
CTGAAGGAAG CCATGCTGTG CATGGTGTGC TGCGAGGAGG AGATCAACTC CACCTTCTGT 
CCCTGTGGCC ACACTGTGTG CTGTGAGAGC TGCGCCGCCC AGCTACAGTC ATGTCCCGTC 
TGCAGGTCGC GTGTGGAGCA TGTCCAGCAC GTCTATCTGC CAACGCACAC CAGTCTTCTC 
AATCTGACTG TAATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYLIP ( NM_013262.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037394.2 Homo sapiens myosin regulatory light chain interacting protein (MYLIP), mRNA.

Price & Availability↑

CloneID	OHu24766
Clone ID Related Accession (Same CDS sequence)	NM_013262.3 , NM_013262.4
Accession Version	NM_013262.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase MYLIP
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK074391.1, AK026739.1 and AF212221.1. On Nov 23, 2018 this sequence version replaced NM_013262.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK074391.1, SRR1803616.246318.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000356840.8/ ENSP00000349298.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGTGTT ATGTGACGAG GCCGGACGCG GTGCTGATGG AGGTGGAGGT GGAGGCGAAA 
GCCAACGGCG AGGACTGCCT CAACCAGGTG TGCAGGCGAC TGGGAATCAT AGAAGTTGAC 
TATTTTGGAC TGCAGTTTAC GGGTAGCAAA GGTGAAAGTT TATGGCTAAA CCTGAGAAAC 
CGGATCTCCC AGCAGATGGA TGGGCTAGCC CCTTACAGGC TTAAACTTAG AGTCAAGTTC 
TTCGTGGAGC CTCATCTCAT CTTACAGGAG CAGACTAGGC ATATCTTTTT CTTGCACATC 
AAGGAGGCCC TCTTGGCAGG CCACCTCTTG TGTTCCCCAG AGCAGGCAGT GGAACTCAGT 
GCCCTCCTGG CCCAGACCAA GTTTGGAGAC TACAACCAGA ACACTGCCAA GTATAACTAT 
GAGGAGCTCT GTGCCAAGGA GCTCTCCTCT GCCACCTTGA ACAGCATTGT TGCAAAACAT 
AAGGAGTTGG AGGGGACCAG CCAGGCTTCA GCTGAATACC AAGTTTTGCA GATTGTGTCG 
GCAATGGAAA ACTATGGCAT AGAATGGCAT TCTGTGCGGG ATAGCGAAGG GCAGAAACTG 
CTCATTGGGG TTGGACCTGA AGGAATCTCA ATTTGTAAAG ATGACTTTAG CCCAATTAAT 
AGGATAGCTT ATCCTGTGGT GCAGATGGCC ACCCAGTCAG GAAAGAATGT ATATTTGACG 
GTCACCAAGG AATCTGGGAA CAGCATCGTG CTCTTGTTTA AAATGATCAG CACCAGGGCG 
GCCAGCGGGC TCTACCGAGC GATAACAGAG ACGCACGCAT TCTACAGGTG TGACACAGTG 
ACCAGCGCCG TGATGATGCA GTATAGCCGT GACTTGAAGG GCCACTTGGC ATCTCTGTTT 
CTGAATGAAA ACATTAACCT TGGCAAGAAA TATGTCTTTG ATATTAAAAG AACATCAAAG 
GAGGTGTATG ACCATGCCAG GAGGGCTCTG TACAATGCTG GCGTTGTGGA CCTCGTTTCA 
AGAAACAACC AGAGCCCTTC ACACTCGCCT CTGAAGTCCT CAGAAAGCAG CATGAACTGC 
AGCAGCTGCG AGGGCCTCAG CTGCCAGCAG ACCCGGGTGC TGCAGGAGAA GCTACGCAAG 
CTGAAGGAAG CCATGCTGTG CATGGTGTGC TGCGAGGAGG AGATCAACTC CACCTTCTGT 
CCCTGTGGCC ACACTGTGTG CTGTGAGAGC TGCGCCGCCC AGCTACAGTC ATGTCCCGTC 
TGCAGGTCGC GTGTGGAGCA TGTCCAGCAC GTCTATCTGC CAACGCACAC CAGTCTTCTC 
AATCTGACTG TAATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037394.2
CDS	238..1575
Translation	MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI

Target ORF information:

RefSeq Version	NM_013262.4
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin regulatory light chain interacting protein (MYLIP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013262.4

ORF Insert Sequence:

ATGCTGTGTT ATGTGACGAG GCCGGACGCG GTGCTGATGG AGGTGGAGGT GGAGGCGAAA 
GCCAACGGCG AGGACTGCCT CAACCAGGTG TGCAGGCGAC TGGGAATCAT AGAAGTTGAC 
TATTTTGGAC TGCAGTTTAC GGGTAGCAAA GGTGAAAGTT TATGGCTAAA CCTGAGAAAC 
CGGATCTCCC AGCAGATGGA TGGGCTAGCC CCTTACAGGC TTAAACTTAG AGTCAAGTTC 
TTCGTGGAGC CTCATCTCAT CTTACAGGAG CAGACTAGGC ATATCTTTTT CTTGCACATC 
AAGGAGGCCC TCTTGGCAGG CCACCTCTTG TGTTCCCCAG AGCAGGCAGT GGAACTCAGT 
GCCCTCCTGG CCCAGACCAA GTTTGGAGAC TACAACCAGA ACACTGCCAA GTATAACTAT 
GAGGAGCTCT GTGCCAAGGA GCTCTCCTCT GCCACCTTGA ACAGCATTGT TGCAAAACAT 
AAGGAGTTGG AGGGGACCAG CCAGGCTTCA GCTGAATACC AAGTTTTGCA GATTGTGTCG 
GCAATGGAAA ACTATGGCAT AGAATGGCAT TCTGTGCGGG ATAGCGAAGG GCAGAAACTG 
CTCATTGGGG TTGGACCTGA AGGAATCTCA ATTTGTAAAG ATGACTTTAG CCCAATTAAT 
AGGATAGCTT ATCCTGTGGT GCAGATGGCC ACCCAGTCAG GAAAGAATGT ATATTTGACG 
GTCACCAAGG AATCTGGGAA CAGCATCGTG CTCTTGTTTA AAATGATCAG CACCAGGGCG 
GCCAGCGGGC TCTACCGAGC GATAACAGAG ACGCACGCAT TCTACAGGTG TGACACAGTG 
ACCAGCGCCG TGATGATGCA GTATAGCCGT GACTTGAAGG GCCACTTGGC ATCTCTGTTT 
CTGAATGAAA ACATTAACCT TGGCAAGAAA TATGTCTTTG ATATTAAAAG AACATCAAAG 
GAGGTGTATG ACCATGCCAG GAGGGCTCTG TACAATGCTG GCGTTGTGGA CCTCGTTTCA 
AGAAACAACC AGAGCCCTTC ACACTCGCCT CTGAAGTCCT CAGAAAGCAG CATGAACTGC 
AGCAGCTGCG AGGGCCTCAG CTGCCAGCAG ACCCGGGTGC TGCAGGAGAA GCTACGCAAG 
CTGAAGGAAG CCATGCTGTG CATGGTGTGC TGCGAGGAGG AGATCAACTC CACCTTCTGT 
CCCTGTGGCC ACACTGTGTG CTGTGAGAGC TGCGCCGCCC AGCTACAGTC ATGTCCCGTC 
TGCAGGTCGC GTGTGGAGCA TGTCCAGCAC GTCTATCTGC CAACGCACAC CAGTCTTCTC 
AATCTGACTG TAATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYLIP ( XM_005249033.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005249090.1 Homo sapiens myosin regulatory light chain interacting protein (MYLIP), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu40275
Clone ID Related Accession (Same CDS sequence)	XM_005249033.3 , XM_005249033.2
Accession Version	XM_005249033.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase MYLIP isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005249033.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAAACT ATGGCATAGA ATGGCATTCT GTGCGGGATA GCGAAGGGCA GAAACTGCTC 
ATTGGGGTTG GACCTGAAGG AATCTCAATT TGTAAAGATG ACTTTAGCCC AATTAATAGG 
ATAGCTTATC CTGTGGTGCA GATGGCCACC CAGTCAGGAA AGAATGTATA TTTGACGGTC 
ACCAAGGAAT CTGGGAACAG CATCGTGCTC TTGTTTAAAA TGATCAGCAC CAGGGCGGCC 
AGCGGGCTCT ACCGAGCGAT AACAGAGACG CACGCATTCT ACAGGTGTGA CACAGTGACC 
AGCGCCGTGA TGATGCAGTA TAGCCGTGAC TTGAAGGGCC ACTTGGCATC TCTGTTTCTG 
AATGAAAACA TTAACCTTGG CAAGAAATAT GTCTTTGATA TTAAAAGAAC ATCAAAGGAG 
GTGTATGACC ATGCCAGGAG GGCTCTGTAC AATGCTGGCG TTGTGGACCT CGTTTCAAGA 
AACAACCAGA GCCCTTCACA CTCGCCTCTG AAGTCCTCAG AAAGCAGCAT GAACTGCAGC 
AGCTGCGAGG GCCTCAGCTG CCAGCAGACC CGGGTGCTGC AGGAGAAGCT ACGCAAGCTG 
AAGGAAGCCA TGCTGTGCAT GGTGTGCTGC GAGGAGGAGA TCAACTCCAC CTTCTGTCCC 
TGTGGCCACA CTGTGTGCTG TGAGAGCTGC GCCGCCCAGC TACAGTCATG TCCCGTCTGC 
AGGTCGCGTG TGGAGCATGT CCAGCACGTC TATCTGCCAA CGCACACCAG TCTTCTCAAT 
CTGACTGTAA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005249090.1
CDS	581..1375
Translation	MENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI

Target ORF information:

RefSeq Version	XM_005249033.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin regulatory light chain interacting protein (MYLIP), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005249033.3

ORF Insert Sequence:

ATGGAAAACT ATGGCATAGA ATGGCATTCT GTGCGGGATA GCGAAGGGCA GAAACTGCTC 
ATTGGGGTTG GACCTGAAGG AATCTCAATT TGTAAAGATG ACTTTAGCCC AATTAATAGG 
ATAGCTTATC CTGTGGTGCA GATGGCCACC CAGTCAGGAA AGAATGTATA TTTGACGGTC 
ACCAAGGAAT CTGGGAACAG CATCGTGCTC TTGTTTAAAA TGATCAGCAC CAGGGCGGCC 
AGCGGGCTCT ACCGAGCGAT AACAGAGACG CACGCATTCT ACAGGTGTGA CACAGTGACC 
AGCGCCGTGA TGATGCAGTA TAGCCGTGAC TTGAAGGGCC ACTTGGCATC TCTGTTTCTG 
AATGAAAACA TTAACCTTGG CAAGAAATAT GTCTTTGATA TTAAAAGAAC ATCAAAGGAG 
GTGTATGACC ATGCCAGGAG GGCTCTGTAC AATGCTGGCG TTGTGGACCT CGTTTCAAGA 
AACAACCAGA GCCCTTCACA CTCGCCTCTG AAGTCCTCAG AAAGCAGCAT GAACTGCAGC 
AGCTGCGAGG GCCTCAGCTG CCAGCAGACC CGGGTGCTGC AGGAGAAGCT ACGCAAGCTG 
AAGGAAGCCA TGCTGTGCAT GGTGTGCTGC GAGGAGGAGA TCAACTCCAC CTTCTGTCCC 
TGTGGCCACA CTGTGTGCTG TGAGAGCTGC GCCGCCCAGC TACAGTCATG TCCCGTCTGC 
AGGTCGCGTG TGGAGCATGT CCAGCACGTC TATCTGCCAA CGCACACCAG TCTTCTCAAT 
CTGACTGTAA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYLIP ( XM_005249033.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005249090.1 Homo sapiens myosin regulatory light chain interacting protein (MYLIP), transcript variant X3, mRNA.

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CloneID	OHu40275
Clone ID Related Accession (Same CDS sequence)	XM_005249033.3 , XM_005249033.2
Accession Version	XM_005249033.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase MYLIP isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005249033.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAAACT ATGGCATAGA ATGGCATTCT GTGCGGGATA GCGAAGGGCA GAAACTGCTC 
ATTGGGGTTG GACCTGAAGG AATCTCAATT TGTAAAGATG ACTTTAGCCC AATTAATAGG 
ATAGCTTATC CTGTGGTGCA GATGGCCACC CAGTCAGGAA AGAATGTATA TTTGACGGTC 
ACCAAGGAAT CTGGGAACAG CATCGTGCTC TTGTTTAAAA TGATCAGCAC CAGGGCGGCC 
AGCGGGCTCT ACCGAGCGAT AACAGAGACG CACGCATTCT ACAGGTGTGA CACAGTGACC 
AGCGCCGTGA TGATGCAGTA TAGCCGTGAC TTGAAGGGCC ACTTGGCATC TCTGTTTCTG 
AATGAAAACA TTAACCTTGG CAAGAAATAT GTCTTTGATA TTAAAAGAAC ATCAAAGGAG 
GTGTATGACC ATGCCAGGAG GGCTCTGTAC AATGCTGGCG TTGTGGACCT CGTTTCAAGA 
AACAACCAGA GCCCTTCACA CTCGCCTCTG AAGTCCTCAG AAAGCAGCAT GAACTGCAGC 
AGCTGCGAGG GCCTCAGCTG CCAGCAGACC CGGGTGCTGC AGGAGAAGCT ACGCAAGCTG 
AAGGAAGCCA TGCTGTGCAT GGTGTGCTGC GAGGAGGAGA TCAACTCCAC CTTCTGTCCC 
TGTGGCCACA CTGTGTGCTG TGAGAGCTGC GCCGCCCAGC TACAGTCATG TCCCGTCTGC 
AGGTCGCGTG TGGAGCATGT CCAGCACGTC TATCTGCCAA CGCACACCAG TCTTCTCAAT 
CTGACTGTAA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005249090.1
CDS	505..1299
Translation	MENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI

Target ORF information:

RefSeq Version	XM_005249033.2
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin regulatory light chain interacting protein (MYLIP), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005249033.2

ORF Insert Sequence:

ATGGAAAACT ATGGCATAGA ATGGCATTCT GTGCGGGATA GCGAAGGGCA GAAACTGCTC 
ATTGGGGTTG GACCTGAAGG AATCTCAATT TGTAAAGATG ACTTTAGCCC AATTAATAGG 
ATAGCTTATC CTGTGGTGCA GATGGCCACC CAGTCAGGAA AGAATGTATA TTTGACGGTC 
ACCAAGGAAT CTGGGAACAG CATCGTGCTC TTGTTTAAAA TGATCAGCAC CAGGGCGGCC 
AGCGGGCTCT ACCGAGCGAT AACAGAGACG CACGCATTCT ACAGGTGTGA CACAGTGACC 
AGCGCCGTGA TGATGCAGTA TAGCCGTGAC TTGAAGGGCC ACTTGGCATC TCTGTTTCTG 
AATGAAAACA TTAACCTTGG CAAGAAATAT GTCTTTGATA TTAAAAGAAC ATCAAAGGAG 
GTGTATGACC ATGCCAGGAG GGCTCTGTAC AATGCTGGCG TTGTGGACCT CGTTTCAAGA 
AACAACCAGA GCCCTTCACA CTCGCCTCTG AAGTCCTCAG AAAGCAGCAT GAACTGCAGC 
AGCTGCGAGG GCCTCAGCTG CCAGCAGACC CGGGTGCTGC AGGAGAAGCT ACGCAAGCTG 
AAGGAAGCCA TGCTGTGCAT GGTGTGCTGC GAGGAGGAGA TCAACTCCAC CTTCTGTCCC 
TGTGGCCACA CTGTGTGCTG TGAGAGCTGC GCCGCCCAGC TACAGTCATG TCCCGTCTGC 
AGGTCGCGTG TGGAGCATGT CCAGCACGTC TATCTGCCAA CGCACACCAG TCTTCTCAAT 
CTGACTGTAA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYLIP ( XM_005249032.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005249089.1 Homo sapiens myosin regulatory light chain interacting protein (MYLIP), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu40274
Clone ID Related Accession (Same CDS sequence)	XM_005249032.2
Accession Version	XM_005249032.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase MYLIP isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005249032.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGTGTT ATGTGACGAG GCCGGACGCG GTGCTGATGG AGGTGGAGGT GGAGGCGAAA 
GCCAACGGCG AGGACTGCCT CAACCAGGTG TGCAGGCGAC TGGGAATCAT AGAAGTTGAC 
TATTTTGGAC TGCAGTTTAC GGGTAGCAAA GGTGAAAGTT TATGGCTAAA CCTGAGAAAC 
CGGATCTCCC AGCAGATGGA TGGGCTAGCC CCTTACAGGC TTAAACTTAG AGTCAAGTTC 
TTCGTGGAGC CTCATCTCAT CTTACAGGAG CAGACTAGGC ATATCTTTTT CTTGCACATC 
AAGGAGGCCC TCTTGGCAGG CCACCTCTTG TGTTCCCCAG AGCAGGCAGT GGAACTCAGT 
GCCCTCCTGG CCCAGACCAA GTTTGGAGAC TACAACCAGA ACACTGCCAA GTATAACTAT 
GAGGAGCTCT GTGCCAAGGA GCTCTCCTCT GCCACCTTGA ACAGCATTGT TGCAAAACAT 
AAGGAGTTGG AGGGGACCAG CCAGGCTTCA GCTGAATACC AAGTTTTGCA GATTGTGTCG 
GCAATGGAAA ACTATGGCAT AGAATGGCAT TCTGTGCGGG ATAGCGAAGG GCAGAAACTG 
CTCATTGGGG TTGGACCTGA AGGAATCTCA ATTTGTAAAG ATGACTTTAG CCCAATTAAT 
AGGTGTGACA CAGTGACCAG CGCCGTGATG ATGCAGTATA GCCGTGACTT GAAGGGCCAC 
TTGGCATCTC TGTTTCTGAA TGAAAACATT AACCTTGGCA AGAAATATGT CTTTGATATT 
AAAAGAACAT CAAAGGAGGT GTATGACCAT GCCAGGAGGG CTCTGTACAA TGCTGGCGTT 
GTGGACCTCG TTTCAAGAAA CAACCAGAGC CCTTCACACT CGCCTCTGAA GTCCTCAGAA 
AGCAGCATGA ACTGCAGCAG CTGCGAGGGC CTCAGCTGCC AGCAGACCCG GGTGCTGCAG 
GAGAAGCTAC GCAAGCTGAA GGAAGCCATG CTGTGCATGG TGTGCTGCGA GGAGGAGATC 
AACTCCACCT TCTGTCCCTG TGGCCACACT GTGTGCTGTG AGAGCTGCGC CGCCCAGCTA 
CAGTCATGTC CCGTCTGCAG GTCGCGTGTG GAGCATGTCC AGCACGTCTA TCTGCCAACG 
CACACCAGTC TTCTCAATCT GACTGTAATC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005249089.1
CDS	238..1410
Translation	MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI

Target ORF information:

RefSeq Version	XM_005249032.2
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin regulatory light chain interacting protein (MYLIP), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005249032.2

ORF Insert Sequence:

ATGCTGTGTT ATGTGACGAG GCCGGACGCG GTGCTGATGG AGGTGGAGGT GGAGGCGAAA 
GCCAACGGCG AGGACTGCCT CAACCAGGTG TGCAGGCGAC TGGGAATCAT AGAAGTTGAC 
TATTTTGGAC TGCAGTTTAC GGGTAGCAAA GGTGAAAGTT TATGGCTAAA CCTGAGAAAC 
CGGATCTCCC AGCAGATGGA TGGGCTAGCC CCTTACAGGC TTAAACTTAG AGTCAAGTTC 
TTCGTGGAGC CTCATCTCAT CTTACAGGAG CAGACTAGGC ATATCTTTTT CTTGCACATC 
AAGGAGGCCC TCTTGGCAGG CCACCTCTTG TGTTCCCCAG AGCAGGCAGT GGAACTCAGT 
GCCCTCCTGG CCCAGACCAA GTTTGGAGAC TACAACCAGA ACACTGCCAA GTATAACTAT 
GAGGAGCTCT GTGCCAAGGA GCTCTCCTCT GCCACCTTGA ACAGCATTGT TGCAAAACAT 
AAGGAGTTGG AGGGGACCAG CCAGGCTTCA GCTGAATACC AAGTTTTGCA GATTGTGTCG 
GCAATGGAAA ACTATGGCAT AGAATGGCAT TCTGTGCGGG ATAGCGAAGG GCAGAAACTG 
CTCATTGGGG TTGGACCTGA AGGAATCTCA ATTTGTAAAG ATGACTTTAG CCCAATTAAT 
AGGTGTGACA CAGTGACCAG CGCCGTGATG ATGCAGTATA GCCGTGACTT GAAGGGCCAC 
TTGGCATCTC TGTTTCTGAA TGAAAACATT AACCTTGGCA AGAAATATGT CTTTGATATT 
AAAAGAACAT CAAAGGAGGT GTATGACCAT GCCAGGAGGG CTCTGTACAA TGCTGGCGTT 
GTGGACCTCG TTTCAAGAAA CAACCAGAGC CCTTCACACT CGCCTCTGAA GTCCTCAGAA 
AGCAGCATGA ACTGCAGCAG CTGCGAGGGC CTCAGCTGCC AGCAGACCCG GGTGCTGCAG 
GAGAAGCTAC GCAAGCTGAA GGAAGCCATG CTGTGCATGG TGTGCTGCGA GGAGGAGATC 
AACTCCACCT TCTGTCCCTG TGGCCACACT GTGTGCTGTG AGAGCTGCGC CGCCCAGCTA 
CAGTCATGTC CCGTCTGCAG GTCGCGTGTG GAGCATGTCC AGCACGTCTA TCTGCCAACG 
CACACCAGTC TTCTCAATCT GACTGTAATC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYLIP ( XM_017010789.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016866278.1 Homo sapiens myosin regulatory light chain interacting protein (MYLIP), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu96563
Clone ID Related Accession (Same CDS sequence)	XM_017010789.1
Accession Version	XM_017010789.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase MYLIP isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGTGTT ATGTGACGAG GCCGGACGCG GTGCTGATGG AGGTGGAGGT GGAGGCGAAA 
GCCAACGGCG AGGACTGCCT CAACCAGGTG TGCAGGCGAC TGGGAATCAT AGAAGTTGAC 
TATTTTGGAC TGCAGTTTAC GGGTAGCAAA GGTGAAAGTT TATGGCTAAA CCTGAGAAAC 
CGGATCTCCC AGCAGATGGA TGGGCTAGCC CCTTACAGGC TTAAACTTAG AGTCAAGTTC 
TTCGTGGAGC CTCATCTCAT CTTACAGGAG CAGACTAGGC ATATCTTTTT CTTGCACATC 
AAGGAGGCCC TCTTGGCAGG CCACCTCTTG TGTTCCCCAG AGCAGGCAGT GGAACTCAGT 
GCCCTCCTGG CCCAGACCAA GTTTGGAGAC TACAACCAGA ACACTGCCAA GTATAACTAT 
GAGGAGCTCT GTGCCAAGGA GCTCTCCTCT GCCACCTTGA ACAGCATTGT TGCAAAACAT 
AAGGAGTTGG AGGGGACCAG CCAGGCTTCA GCTGAATACC AAGTTTTGCA GATTGTGTCG 
GCAATGGAAA ACTATGGCAT AGAATGGCAT TCTGTGCGGG ATAGCGAAGG GCAGAAACTG 
CTCATTGGGG TTGGACCTGA AGGAATCTCA ATTTGTAAAG ATGACTTTAG CCCAATTAAT 
AGGATAGCTT ATCCTGTGGT GCAGATGGCC ACCCAGTCAG GAAAGAATGT ATATTTGACG 
GTCACCAAGG AATCTGGGAA CAGCATCGTG CTCTTGTTTA AAATGATCAG CACCAGGGCG 
GCCAGCGGGC TCTACCGAGC GATAACAGAG ACGCACGCAT TCTACAGGTG TGACACAGTG 
ACCAGCGCCG TGATGATGCA GTATAGCCGT GACTTGAAGG GCCACTTGGC ATCTCTGTTT 
CTGAATGAAA ACATTAACCT TGGCAAGAAA TATGTCTTTG ATATTAAAAG AACATCAAAG 
GAGGTGTATG ACCATGCCAG GAGGGCTCTG TACAATGCTG GCGTTGTGGA CCTCGTTTCA 
AGAAACAACC AGAGCCCTTC ACACTCGCCT CTGAAGTCCT CAGAAAGCAG CATGAACTGC 
AGCAGCTGCG AGGGCCTCAG CTGCCAGCAG ACCCGGGTGC TGCAGGAGAA GCTACGCAAG 
CTGAAGGAAG CCATGCTGTG CATGGTGTGC TGCGAGGAGG AGATCAACTC CACCTTCTGT 
CCCTGTGGCC ACACTGTGTG CTGTGAGAGC TGCGCCGCCC AGCTACAGGA TGAGCTCGAA 
TGCAACGCTG GGAAGTTCTG GGGGGAAGTG TCCCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016866278.1
CDS	238..1536
Translation	MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQDELECNAGKFWGEVSP

Target ORF information:

RefSeq Version	XM_017010789.1
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin regulatory light chain interacting protein (MYLIP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017010789.1

ORF Insert Sequence:

ATGCTGTGTT ATGTGACGAG GCCGGACGCG GTGCTGATGG AGGTGGAGGT GGAGGCGAAA 
GCCAACGGCG AGGACTGCCT CAACCAGGTG TGCAGGCGAC TGGGAATCAT AGAAGTTGAC 
TATTTTGGAC TGCAGTTTAC GGGTAGCAAA GGTGAAAGTT TATGGCTAAA CCTGAGAAAC 
CGGATCTCCC AGCAGATGGA TGGGCTAGCC CCTTACAGGC TTAAACTTAG AGTCAAGTTC 
TTCGTGGAGC CTCATCTCAT CTTACAGGAG CAGACTAGGC ATATCTTTTT CTTGCACATC 
AAGGAGGCCC TCTTGGCAGG CCACCTCTTG TGTTCCCCAG AGCAGGCAGT GGAACTCAGT 
GCCCTCCTGG CCCAGACCAA GTTTGGAGAC TACAACCAGA ACACTGCCAA GTATAACTAT 
GAGGAGCTCT GTGCCAAGGA GCTCTCCTCT GCCACCTTGA ACAGCATTGT TGCAAAACAT 
AAGGAGTTGG AGGGGACCAG CCAGGCTTCA GCTGAATACC AAGTTTTGCA GATTGTGTCG 
GCAATGGAAA ACTATGGCAT AGAATGGCAT TCTGTGCGGG ATAGCGAAGG GCAGAAACTG 
CTCATTGGGG TTGGACCTGA AGGAATCTCA ATTTGTAAAG ATGACTTTAG CCCAATTAAT 
AGGATAGCTT ATCCTGTGGT GCAGATGGCC ACCCAGTCAG GAAAGAATGT ATATTTGACG 
GTCACCAAGG AATCTGGGAA CAGCATCGTG CTCTTGTTTA AAATGATCAG CACCAGGGCG 
GCCAGCGGGC TCTACCGAGC GATAACAGAG ACGCACGCAT TCTACAGGTG TGACACAGTG 
ACCAGCGCCG TGATGATGCA GTATAGCCGT GACTTGAAGG GCCACTTGGC ATCTCTGTTT 
CTGAATGAAA ACATTAACCT TGGCAAGAAA TATGTCTTTG ATATTAAAAG AACATCAAAG 
GAGGTGTATG ACCATGCCAG GAGGGCTCTG TACAATGCTG GCGTTGTGGA CCTCGTTTCA 
AGAAACAACC AGAGCCCTTC ACACTCGCCT CTGAAGTCCT CAGAAAGCAG CATGAACTGC 
AGCAGCTGCG AGGGCCTCAG CTGCCAGCAG ACCCGGGTGC TGCAGGAGAA GCTACGCAAG 
CTGAAGGAAG CCATGCTGTG CATGGTGTGC TGCGAGGAGG AGATCAACTC CACCTTCTGT 
CCCTGTGGCC ACACTGTGTG CTGTGAGAGC TGCGCCGCCC AGCTACAGGA TGAGCTCGAA 
TGCAACGCTG GGAAGTTCTG GGGGGAAGTG TCCCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol.
Circulation. Cardiovascular genetics9(3)223-30(2016 Jun)
Mitchel K,Theusch E,Cubitt C,Dos? AC,Stevens K,Naidoo D,Medina MW

Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol.
Cardiovascular research110(1)23-9(2016 May)
Ibrahim S,Somanathan S,Billheimer J,Wilson JM,Rader DJ

The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.
Circulation research118(3)410-9(2016 Feb)
Nelson JK,Sorrentino V,Avagliano Trezza R,Heride C,Urbe S,Distel B,Zelcer N

Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.
The Journal of biological chemistry291(9)4813-25(2016 Feb)
Nelson JK,Cook EC,Loregger A,Hoeksema MA,Scheij S,Kovacevic I,Hordijk PL,Ovaa H,Zelcer N

IDOL, inducible degrader of low-density lipoprotein receptor, serves as a potential therapeutic target for dyslipidemia.
Medical hypotheses86138-42(2016 Jan)
Zhang CP,Tian Y,Zhang M,Tuo QH,Chen JX,Liao DF

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MYLIP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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FAX

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