TBK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TBK1
Entrez Gene ID	29110
Full Name	TANK binding kinase 1
Synonyms	FTDALS4,NAK,T2K
General protein information	Preferred Names TANK binding kinase 1 Names serine/threonine-protein kinase TBK1 NF-kB-activating kinase NF-kappa-B-activating kinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q14.2
Summary	The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010].
Disorder MIM:	604834
Disorder Html:	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4, 616439 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005268810.1	XP_005268867.1	serine/threonine-protein kinase TBK1 isoform X1
NM_013254.3	NP_037386.1	serine/threonine-protein kinase TBK1
XM_005268809.1	XP_005268866.1	serine/threonine-protein kinase TBK1 isoform X1
NM_013254.4	NP_037386.1	serine/threonine-protein kinase TBK1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TBK1	XP_538266.3
Mus musculus (house mouse)	Tbk1	NP_062760.3
Drosophila melanogaster (fruit fly)	ik2	NP_610048.2
Bos taurus (cattle)	TBK1	NP_001179684.1
Rattus norvegicus (Norway rat)	Tbk1	NP_001100256.1
Xenopus tropicalis (tropical clawed frog)	tbk1	NP_001135652.1
Pan troglodytes (chimpanzee)	TBK1	XP_509194.2
	TBK1	XP_001116924.1
Gallus gallus (chicken)	TBK1	NP_001186487.1
Danio rerio (zebrafish)	tbk1	NP_001038213.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009565	XP_318573.3
Homo sapiens (human)	TBK1	NP_037386.1

Gene Ontology
Bibliography

Related articles in PubMed

Genomic Organization of TBK1 Copy Number Variations in Glaucoma Patients.
DeLuca AP, Alward WLM, Liebmann J, Ritch R, Kawase K, Kwon YH, Robin AL, Stone EM, Scheetz TE, Fingert JH
Journal of glaucoma26(12)1063-1067(2017 Dec)

USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.
Yu Z, Song H, Jia M, Zhang J, Wang W, Li Q, Zhang L, Zhao W
The Journal of experimental medicine214(12)3553-3563(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we detected no statistical difference in age at diagnosis or maximum IOP when we compared patients with a TBK1 gene duplication and patients with a TBK1 gene triplication.
Title: Genomic Organization of TBK1 Copy Number Variations in Glaucoma Patients.

These results outline a novel mechanism for the control of TBK1 activity and suggest USP1-UAF1 complex as a potential target for the prevention of viral diseases.
Title: USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.

HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress
Title: HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress.

these data suggest that HNSs, an antagonist of host innate immunity, interacts with TBK1 and thereby hinders the association of TBK1 with its substrate IRF3, thus blocking IRF3 activation and transcriptional induction of the cellular antiviral responses.
Title: Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction.

We identified novel genomic TBK1 variants including two loss-of-function (LoF) (p.Leu59Phefs*16 and c.358+5G>A), two missense (p.Asp118Asn and p.Ile397Thr) and one intronic variant (c.1644-5_1644-2delAATA).

The following TBK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TBK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15095	NM_013254.4 Latest version!	Homo sapiens TANK binding kinase 1 (TBK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu15095	XM_005268810.1 Latest version!	Homo sapiens TANK binding kinase 1 (TBK1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu15095	XM_005268809.1 Latest version!	Homo sapiens TANK binding kinase 1 (TBK1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu15095	NM_013254.3	Homo sapiens TANK binding kinase 1 (TBK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TBK1 ( NM_013254.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037386.1 Homo sapiens TANK binding kinase 1 (TBK1), mRNA.

Price & Availability↑

CloneID	OHu15095
Clone ID Related Accession (Same CDS sequence)	XM_005268810.1 , NM_013254.3 , XM_005268809.1 , NM_013254.4
Accession Version	NM_013254.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase TBK1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA788357.1, BC034950.2, AC135279.3, AC136977.4 and AA970899.1. This sequence is a reference standard in the RefSeqGene project. On Oct 22, 2010 this sequence version replaced NM_013254.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.166692.1, SRR1660809.181724.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCAGAGCA CTTCTAATCA TCTGTGGCTT TTATCTGATA TTTTAGGCCA AGGAGCTACT 
GCAAATGTCT TTCGTGGAAG ACATAAGAAA ACTGGTGATT TATTTGCTAT CAAAGTATTT 
AATAACATAA GCTTCCTTCG TCCAGTGGAT GTTCAAATGA GAGAATTTGA AGTGTTGAAA 
AAACTCAATC ACAAAAATAT TGTCAAATTA TTTGCTATTG AAGAGGAGAC AACAACAAGA 
CATAAAGTAC TTATTATGGA ATTTTGTCCA TGTGGGAGTT TATACACTGT TTTAGAAGAA 
CCTTCTAATG CCTATGGACT ACCAGAATCT GAATTCTTAA TTGTTTTGCG AGATGTGGTG 
GGTGGAATGA ATCATCTACG AGAGAATGGT ATAGTGCACC GTGATATCAA GCCAGGAAAT 
ATCATGCGTG TTATAGGGGA AGATGGACAG TCTGTGTACA AACTCACAGA TTTTGGTGCA 
GCTAGAGAAT TAGAAGATGA TGAGCAGTTT GTTTCTCTGT ATGGCACAGA AGAATATTTG 
CACCCTGATA TGTATGAGAG AGCAGTGCTA AGAAAAGATC ATCAGAAGAA ATATGGAGCA 
ACAGTTGATC TTTGGAGCAT TGGGGTAACA TTTTACCATG CAGCTACTGG ATCACTGCCA 
TTTAGACCCT TTGAAGGGCC TCGTAGGAAT AAAGAAGTGA TGTATAAAAT AATTACAGGA 
AAGCCTTCTG GTGCAATATC TGGAGTACAG AAAGCAGAAA ATGGACCAAT TGACTGGAGT 
GGAGACATGC CTGTTTCTTG CAGTCTTTCT CGGGGTCTTC AGGTTCTACT TACCCCTGTT 
CTTGCAAACA TCCTTGAAGC AGATCAGGAA AAGTGTTGGG GTTTTGACCA GTTTTTTGCA 
GAAACTAGTG ATATACTTCA CCGAATGGTA ATTCATGTTT TTTCGCTACA ACAAATGACA 
GCTCATAAGA TTTATATTCA TAGCTATAAT ACTGCTACTA TATTTCATGA ACTGGTATAT 
AAACAAACCA AAATTATTTC TTCAAATCAA GAACTTATCT ACGAAGGGCG ACGCTTAGTC 
TTAGAACCTG GAAGGCTGGC ACAACATTTC CCTAAAACTA CTGAGGAAAA CCCTATATTT 
GTAGTAAGCC GGGAACCTCT GAATACCATA GGATTAATAT ATGAAAAAAT TTCCCTCCCT 
AAAGTACATC CACGTTATGA TTTAGACGGG GATGCTAGCA TGGCTAAGGC AATAACAGGG 
GTTGTGTGTT ATGCCTGCAG AATTGCCAGT ACCTTACTGC TTTATCAGGA ATTAATGCGA 
AAGGGGATAC GATGGCTGAT TGAATTAATT AAAGATGATT ACAATGAAAC TGTTCACAAA 
AAGACAGAAG TTGTGATCAC ATTGGATTTC TGTATCAGAA ACATTGAAAA AACTGTGAAA 
GTATATGAAA AGTTGATGAA GATCAACCTG GAAGCGGCAG AGTTAGGTGA AATTTCAGAC 
ATACACACCA AATTGTTGAG ACTTTCCAGT TCTCAGGGAA CAATAGAAAC CAGTCTTCAG 
GATATCGACA GCAGATTATC TCCAGGTGGA TCACTGGCAG ACGCATGGGC ACATCAAGAA 
GGCACTCATC CGAAAGACAG AAATGTAGAA AAACTACAAG TCCTGTTAAA TTGCATGACA 
GAGATTTACT ATCAGTTCAA AAAAGACAAA GCAGAACGTA GATTAGCTTA TAATGAAGAA 
CAAATCCACA AATTTGATAA GCAAAAACTG TATTACCATG CCACAAAAGC TATGACGCAC 
TTTACAGATG AATGTGTTAA AAAGTATGAG GCATTTTTGA ATAAGTCAGA AGAATGGATA 
AGAAAGATGC TTCATCTTAG GAAACAGTTA TTATCGCTGA CTAATCAGTG TTTTGATATT 
GAAGAAGAAG TATCAAAATA TCAAGAATAT ACTAATGAGT TACAAGAAAC TCTGCCTCAG 
AAAATGTTTA CAGCTTCCAG TGGAATCAAA CATACCATGA CCCCAATTTA TCCAAGTTCT 
AACACATTAG TAGAAATGAC TCTTGGTATG AAGAAATTAA AGGAAGAGAT GGAAGGGGTG 
GTTAAAGAAC TTGCTGAAAA TAACCACATT TTAGAAAGGT TTGGCTCTTT AACCATGGAT 
GGTGGCCTTC GCAACGTTGA CTGTCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037386.1
CDS	160..2349
Translation	MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL

Target ORF information:

RefSeq Version	NM_013254.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TANK binding kinase 1 (TBK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013254.3

ORF Insert Sequence:

ATGCAGAGCA CTTCTAATCA TCTGTGGCTT TTATCTGATA TTTTAGGCCA AGGAGCTACT 
GCAAATGTCT TTCGTGGAAG ACATAAGAAA ACTGGTGATT TATTTGCTAT CAAAGTATTT 
AATAACATAA GCTTCCTTCG TCCAGTGGAT GTTCAAATGA GAGAATTTGA AGTGTTGAAA 
AAACTCAATC ACAAAAATAT TGTCAAATTA TTTGCTATTG AAGAGGAGAC AACAACAAGA 
CATAAAGTAC TTATTATGGA ATTTTGTCCA TGTGGGAGTT TATACACTGT TTTAGAAGAA 
CCTTCTAATG CCTATGGACT ACCAGAATCT GAATTCTTAA TTGTTTTGCG AGATGTGGTG 
GGTGGAATGA ATCATCTACG AGAGAATGGT ATAGTGCACC GTGATATCAA GCCAGGAAAT 
ATCATGCGTG TTATAGGGGA AGATGGACAG TCTGTGTACA AACTCACAGA TTTTGGTGCA 
GCTAGAGAAT TAGAAGATGA TGAGCAGTTT GTTTCTCTGT ATGGCACAGA AGAATATTTG 
CACCCTGATA TGTATGAGAG AGCAGTGCTA AGAAAAGATC ATCAGAAGAA ATATGGAGCA 
ACAGTTGATC TTTGGAGCAT TGGGGTAACA TTTTACCATG CAGCTACTGG ATCACTGCCA 
TTTAGACCCT TTGAAGGGCC TCGTAGGAAT AAAGAAGTGA TGTATAAAAT AATTACAGGA 
AAGCCTTCTG GTGCAATATC TGGAGTACAG AAAGCAGAAA ATGGACCAAT TGACTGGAGT 
GGAGACATGC CTGTTTCTTG CAGTCTTTCT CGGGGTCTTC AGGTTCTACT TACCCCTGTT 
CTTGCAAACA TCCTTGAAGC AGATCAGGAA AAGTGTTGGG GTTTTGACCA GTTTTTTGCA 
GAAACTAGTG ATATACTTCA CCGAATGGTA ATTCATGTTT TTTCGCTACA ACAAATGACA 
GCTCATAAGA TTTATATTCA TAGCTATAAT ACTGCTACTA TATTTCATGA ACTGGTATAT 
AAACAAACCA AAATTATTTC TTCAAATCAA GAACTTATCT ACGAAGGGCG ACGCTTAGTC 
TTAGAACCTG GAAGGCTGGC ACAACATTTC CCTAAAACTA CTGAGGAAAA CCCTATATTT 
GTAGTAAGCC GGGAACCTCT GAATACCATA GGATTAATAT ATGAAAAAAT TTCCCTCCCT 
AAAGTACATC CACGTTATGA TTTAGACGGG GATGCTAGCA TGGCTAAGGC AATAACAGGG 
GTTGTGTGTT ATGCCTGCAG AATTGCCAGT ACCTTACTGC TTTATCAGGA ATTAATGCGA 
AAGGGGATAC GATGGCTGAT TGAATTAATT AAAGATGATT ACAATGAAAC TGTTCACAAA 
AAGACAGAAG TTGTGATCAC ATTGGATTTC TGTATCAGAA ACATTGAAAA AACTGTGAAA 
GTATATGAAA AGTTGATGAA GATCAACCTG GAAGCGGCAG AGTTAGGTGA AATTTCAGAC 
ATACACACCA AATTGTTGAG ACTTTCCAGT TCTCAGGGAA CAATAGAAAC CAGTCTTCAG 
GATATCGACA GCAGATTATC TCCAGGTGGA TCACTGGCAG ACGCATGGGC ACATCAAGAA 
GGCACTCATC CGAAAGACAG AAATGTAGAA AAACTACAAG TCCTGTTAAA TTGCATGACA 
GAGATTTACT ATCAGTTCAA AAAAGACAAA GCAGAACGTA GATTAGCTTA TAATGAAGAA 
CAAATCCACA AATTTGATAA GCAAAAACTG TATTACCATG CCACAAAAGC TATGACGCAC 
TTTACAGATG AATGTGTTAA AAAGTATGAG GCATTTTTGA ATAAGTCAGA AGAATGGATA 
AGAAAGATGC TTCATCTTAG GAAACAGTTA TTATCGCTGA CTAATCAGTG TTTTGATATT 
GAAGAAGAAG TATCAAAATA TCAAGAATAT ACTAATGAGT TACAAGAAAC TCTGCCTCAG 
AAAATGTTTA CAGCTTCCAG TGGAATCAAA CATACCATGA CCCCAATTTA TCCAAGTTCT 
AACACATTAG TAGAAATGAC TCTTGGTATG AAGAAATTAA AGGAAGAGAT GGAAGGGGTG 
GTTAAAGAAC TTGCTGAAAA TAACCACATT TTAGAAAGGT TTGGCTCTTT AACCATGGAT 
GGTGGCCTTC GCAACGTTGA CTGTCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBK1 ( NM_013254.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037386.1 Homo sapiens TANK binding kinase 1 (TBK1), mRNA.

Price & Availability↑

CloneID	OHu15095
Clone ID Related Accession (Same CDS sequence)	XM_005268810.1 , NM_013254.3 , XM_005268809.1 , NM_013254.4
Accession Version	NM_013254.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-23
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase TBK1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC034950.2, AC135279.3, AC136977.4 and AA970899.1. This sequence is a reference standard in the RefSeqGene project. On Nov 6, 2018 this sequence version replaced NM_013254.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.267405.1, SRR1803615.195354.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000331710.10/ ENSP00000329967.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGAGCA CTTCTAATCA TCTGTGGCTT TTATCTGATA TTTTAGGCCA AGGAGCTACT 
GCAAATGTCT TTCGTGGAAG ACATAAGAAA ACTGGTGATT TATTTGCTAT CAAAGTATTT 
AATAACATAA GCTTCCTTCG TCCAGTGGAT GTTCAAATGA GAGAATTTGA AGTGTTGAAA 
AAACTCAATC ACAAAAATAT TGTCAAATTA TTTGCTATTG AAGAGGAGAC AACAACAAGA 
CATAAAGTAC TTATTATGGA ATTTTGTCCA TGTGGGAGTT TATACACTGT TTTAGAAGAA 
CCTTCTAATG CCTATGGACT ACCAGAATCT GAATTCTTAA TTGTTTTGCG AGATGTGGTG 
GGTGGAATGA ATCATCTACG AGAGAATGGT ATAGTGCACC GTGATATCAA GCCAGGAAAT 
ATCATGCGTG TTATAGGGGA AGATGGACAG TCTGTGTACA AACTCACAGA TTTTGGTGCA 
GCTAGAGAAT TAGAAGATGA TGAGCAGTTT GTTTCTCTGT ATGGCACAGA AGAATATTTG 
CACCCTGATA TGTATGAGAG AGCAGTGCTA AGAAAAGATC ATCAGAAGAA ATATGGAGCA 
ACAGTTGATC TTTGGAGCAT TGGGGTAACA TTTTACCATG CAGCTACTGG ATCACTGCCA 
TTTAGACCCT TTGAAGGGCC TCGTAGGAAT AAAGAAGTGA TGTATAAAAT AATTACAGGA 
AAGCCTTCTG GTGCAATATC TGGAGTACAG AAAGCAGAAA ATGGACCAAT TGACTGGAGT 
GGAGACATGC CTGTTTCTTG CAGTCTTTCT CGGGGTCTTC AGGTTCTACT TACCCCTGTT 
CTTGCAAACA TCCTTGAAGC AGATCAGGAA AAGTGTTGGG GTTTTGACCA GTTTTTTGCA 
GAAACTAGTG ATATACTTCA CCGAATGGTA ATTCATGTTT TTTCGCTACA ACAAATGACA 
GCTCATAAGA TTTATATTCA TAGCTATAAT ACTGCTACTA TATTTCATGA ACTGGTATAT 
AAACAAACCA AAATTATTTC TTCAAATCAA GAACTTATCT ACGAAGGGCG ACGCTTAGTC 
TTAGAACCTG GAAGGCTGGC ACAACATTTC CCTAAAACTA CTGAGGAAAA CCCTATATTT 
GTAGTAAGCC GGGAACCTCT GAATACCATA GGATTAATAT ATGAAAAAAT TTCCCTCCCT 
AAAGTACATC CACGTTATGA TTTAGACGGG GATGCTAGCA TGGCTAAGGC AATAACAGGG 
GTTGTGTGTT ATGCCTGCAG AATTGCCAGT ACCTTACTGC TTTATCAGGA ATTAATGCGA 
AAGGGGATAC GATGGCTGAT TGAATTAATT AAAGATGATT ACAATGAAAC TGTTCACAAA 
AAGACAGAAG TTGTGATCAC ATTGGATTTC TGTATCAGAA ACATTGAAAA AACTGTGAAA 
GTATATGAAA AGTTGATGAA GATCAACCTG GAAGCGGCAG AGTTAGGTGA AATTTCAGAC 
ATACACACCA AATTGTTGAG ACTTTCCAGT TCTCAGGGAA CAATAGAAAC CAGTCTTCAG 
GATATCGACA GCAGATTATC TCCAGGTGGA TCACTGGCAG ACGCATGGGC ACATCAAGAA 
GGCACTCATC CGAAAGACAG AAATGTAGAA AAACTACAAG TCCTGTTAAA TTGCATGACA 
GAGATTTACT ATCAGTTCAA AAAAGACAAA GCAGAACGTA GATTAGCTTA TAATGAAGAA 
CAAATCCACA AATTTGATAA GCAAAAACTG TATTACCATG CCACAAAAGC TATGACGCAC 
TTTACAGATG AATGTGTTAA AAAGTATGAG GCATTTTTGA ATAAGTCAGA AGAATGGATA 
AGAAAGATGC TTCATCTTAG GAAACAGTTA TTATCGCTGA CTAATCAGTG TTTTGATATT 
GAAGAAGAAG TATCAAAATA TCAAGAATAT ACTAATGAGT TACAAGAAAC TCTGCCTCAG 
AAAATGTTTA CAGCTTCCAG TGGAATCAAA CATACCATGA CCCCAATTTA TCCAAGTTCT 
AACACATTAG TAGAAATGAC TCTTGGTATG AAGAAATTAA AGGAAGAGAT GGAAGGGGTG 
GTTAAAGAAC TTGCTGAAAA TAACCACATT TTAGAAAGGT TTGGCTCTTT AACCATGGAT 
GGTGGCCTTC GCAACGTTGA CTGTCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037386.1
CDS	100..2289
Translation	MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL

Target ORF information:

RefSeq Version	NM_013254.4
Organism	Homo sapiens(human)
Definition	Homo sapiens TANK binding kinase 1 (TBK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013254.4

ORF Insert Sequence:

ATGCAGAGCA CTTCTAATCA TCTGTGGCTT TTATCTGATA TTTTAGGCCA AGGAGCTACT 
GCAAATGTCT TTCGTGGAAG ACATAAGAAA ACTGGTGATT TATTTGCTAT CAAAGTATTT 
AATAACATAA GCTTCCTTCG TCCAGTGGAT GTTCAAATGA GAGAATTTGA AGTGTTGAAA 
AAACTCAATC ACAAAAATAT TGTCAAATTA TTTGCTATTG AAGAGGAGAC AACAACAAGA 
CATAAAGTAC TTATTATGGA ATTTTGTCCA TGTGGGAGTT TATACACTGT TTTAGAAGAA 
CCTTCTAATG CCTATGGACT ACCAGAATCT GAATTCTTAA TTGTTTTGCG AGATGTGGTG 
GGTGGAATGA ATCATCTACG AGAGAATGGT ATAGTGCACC GTGATATCAA GCCAGGAAAT 
ATCATGCGTG TTATAGGGGA AGATGGACAG TCTGTGTACA AACTCACAGA TTTTGGTGCA 
GCTAGAGAAT TAGAAGATGA TGAGCAGTTT GTTTCTCTGT ATGGCACAGA AGAATATTTG 
CACCCTGATA TGTATGAGAG AGCAGTGCTA AGAAAAGATC ATCAGAAGAA ATATGGAGCA 
ACAGTTGATC TTTGGAGCAT TGGGGTAACA TTTTACCATG CAGCTACTGG ATCACTGCCA 
TTTAGACCCT TTGAAGGGCC TCGTAGGAAT AAAGAAGTGA TGTATAAAAT AATTACAGGA 
AAGCCTTCTG GTGCAATATC TGGAGTACAG AAAGCAGAAA ATGGACCAAT TGACTGGAGT 
GGAGACATGC CTGTTTCTTG CAGTCTTTCT CGGGGTCTTC AGGTTCTACT TACCCCTGTT 
CTTGCAAACA TCCTTGAAGC AGATCAGGAA AAGTGTTGGG GTTTTGACCA GTTTTTTGCA 
GAAACTAGTG ATATACTTCA CCGAATGGTA ATTCATGTTT TTTCGCTACA ACAAATGACA 
GCTCATAAGA TTTATATTCA TAGCTATAAT ACTGCTACTA TATTTCATGA ACTGGTATAT 
AAACAAACCA AAATTATTTC TTCAAATCAA GAACTTATCT ACGAAGGGCG ACGCTTAGTC 
TTAGAACCTG GAAGGCTGGC ACAACATTTC CCTAAAACTA CTGAGGAAAA CCCTATATTT 
GTAGTAAGCC GGGAACCTCT GAATACCATA GGATTAATAT ATGAAAAAAT TTCCCTCCCT 
AAAGTACATC CACGTTATGA TTTAGACGGG GATGCTAGCA TGGCTAAGGC AATAACAGGG 
GTTGTGTGTT ATGCCTGCAG AATTGCCAGT ACCTTACTGC TTTATCAGGA ATTAATGCGA 
AAGGGGATAC GATGGCTGAT TGAATTAATT AAAGATGATT ACAATGAAAC TGTTCACAAA 
AAGACAGAAG TTGTGATCAC ATTGGATTTC TGTATCAGAA ACATTGAAAA AACTGTGAAA 
GTATATGAAA AGTTGATGAA GATCAACCTG GAAGCGGCAG AGTTAGGTGA AATTTCAGAC 
ATACACACCA AATTGTTGAG ACTTTCCAGT TCTCAGGGAA CAATAGAAAC CAGTCTTCAG 
GATATCGACA GCAGATTATC TCCAGGTGGA TCACTGGCAG ACGCATGGGC ACATCAAGAA 
GGCACTCATC CGAAAGACAG AAATGTAGAA AAACTACAAG TCCTGTTAAA TTGCATGACA 
GAGATTTACT ATCAGTTCAA AAAAGACAAA GCAGAACGTA GATTAGCTTA TAATGAAGAA 
CAAATCCACA AATTTGATAA GCAAAAACTG TATTACCATG CCACAAAAGC TATGACGCAC 
TTTACAGATG AATGTGTTAA AAAGTATGAG GCATTTTTGA ATAAGTCAGA AGAATGGATA 
AGAAAGATGC TTCATCTTAG GAAACAGTTA TTATCGCTGA CTAATCAGTG TTTTGATATT 
GAAGAAGAAG TATCAAAATA TCAAGAATAT ACTAATGAGT TACAAGAAAC TCTGCCTCAG 
AAAATGTTTA CAGCTTCCAG TGGAATCAAA CATACCATGA CCCCAATTTA TCCAAGTTCT 
AACACATTAG TAGAAATGAC TCTTGGTATG AAGAAATTAA AGGAAGAGAT GGAAGGGGTG 
GTTAAAGAAC TTGCTGAAAA TAACCACATT TTAGAAAGGT TTGGCTCTTT AACCATGGAT 
GGTGGCCTTC GCAACGTTGA CTGTCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBK1 ( XM_005268810.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005268867.1 Homo sapiens TANK binding kinase 1 (TBK1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu15095
Clone ID Related Accession (Same CDS sequence)	XM_005268810.1 , NM_013254.3 , XM_005268809.1 , NM_013254.4
Accession Version	XM_005268810.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase TBK1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGAGCA CTTCTAATCA TCTGTGGCTT TTATCTGATA TTTTAGGCCA AGGAGCTACT 
GCAAATGTCT TTCGTGGAAG ACATAAGAAA ACTGGTGATT TATTTGCTAT CAAAGTATTT 
AATAACATAA GCTTCCTTCG TCCAGTGGAT GTTCAAATGA GAGAATTTGA AGTGTTGAAA 
AAACTCAATC ACAAAAATAT TGTCAAATTA TTTGCTATTG AAGAGGAGAC AACAACAAGA 
CATAAAGTAC TTATTATGGA ATTTTGTCCA TGTGGGAGTT TATACACTGT TTTAGAAGAA 
CCTTCTAATG CCTATGGACT ACCAGAATCT GAATTCTTAA TTGTTTTGCG AGATGTGGTG 
GGTGGAATGA ATCATCTACG AGAGAATGGT ATAGTGCACC GTGATATCAA GCCAGGAAAT 
ATCATGCGTG TTATAGGGGA AGATGGACAG TCTGTGTACA AACTCACAGA TTTTGGTGCA 
GCTAGAGAAT TAGAAGATGA TGAGCAGTTT GTTTCTCTGT ATGGCACAGA AGAATATTTG 
CACCCTGATA TGTATGAGAG AGCAGTGCTA AGAAAAGATC ATCAGAAGAA ATATGGAGCA 
ACAGTTGATC TTTGGAGCAT TGGGGTAACA TTTTACCATG CAGCTACTGG ATCACTGCCA 
TTTAGACCCT TTGAAGGGCC TCGTAGGAAT AAAGAAGTGA TGTATAAAAT AATTACAGGA 
AAGCCTTCTG GTGCAATATC TGGAGTACAG AAAGCAGAAA ATGGACCAAT TGACTGGAGT 
GGAGACATGC CTGTTTCTTG CAGTCTTTCT CGGGGTCTTC AGGTTCTACT TACCCCTGTT 
CTTGCAAACA TCCTTGAAGC AGATCAGGAA AAGTGTTGGG GTTTTGACCA GTTTTTTGCA 
GAAACTAGTG ATATACTTCA CCGAATGGTA ATTCATGTTT TTTCGCTACA ACAAATGACA 
GCTCATAAGA TTTATATTCA TAGCTATAAT ACTGCTACTA TATTTCATGA ACTGGTATAT 
AAACAAACCA AAATTATTTC TTCAAATCAA GAACTTATCT ACGAAGGGCG ACGCTTAGTC 
TTAGAACCTG GAAGGCTGGC ACAACATTTC CCTAAAACTA CTGAGGAAAA CCCTATATTT 
GTAGTAAGCC GGGAACCTCT GAATACCATA GGATTAATAT ATGAAAAAAT TTCCCTCCCT 
AAAGTACATC CACGTTATGA TTTAGACGGG GATGCTAGCA TGGCTAAGGC AATAACAGGG 
GTTGTGTGTT ATGCCTGCAG AATTGCCAGT ACCTTACTGC TTTATCAGGA ATTAATGCGA 
AAGGGGATAC GATGGCTGAT TGAATTAATT AAAGATGATT ACAATGAAAC TGTTCACAAA 
AAGACAGAAG TTGTGATCAC ATTGGATTTC TGTATCAGAA ACATTGAAAA AACTGTGAAA 
GTATATGAAA AGTTGATGAA GATCAACCTG GAAGCGGCAG AGTTAGGTGA AATTTCAGAC 
ATACACACCA AATTGTTGAG ACTTTCCAGT TCTCAGGGAA CAATAGAAAC CAGTCTTCAG 
GATATCGACA GCAGATTATC TCCAGGTGGA TCACTGGCAG ACGCATGGGC ACATCAAGAA 
GGCACTCATC CGAAAGACAG AAATGTAGAA AAACTACAAG TCCTGTTAAA TTGCATGACA 
GAGATTTACT ATCAGTTCAA AAAAGACAAA GCAGAACGTA GATTAGCTTA TAATGAAGAA 
CAAATCCACA AATTTGATAA GCAAAAACTG TATTACCATG CCACAAAAGC TATGACGCAC 
TTTACAGATG AATGTGTTAA AAAGTATGAG GCATTTTTGA ATAAGTCAGA AGAATGGATA 
AGAAAGATGC TTCATCTTAG GAAACAGTTA TTATCGCTGA CTAATCAGTG TTTTGATATT 
GAAGAAGAAG TATCAAAATA TCAAGAATAT ACTAATGAGT TACAAGAAAC TCTGCCTCAG 
AAAATGTTTA CAGCTTCCAG TGGAATCAAA CATACCATGA CCCCAATTTA TCCAAGTTCT 
AACACATTAG TAGAAATGAC TCTTGGTATG AAGAAATTAA AGGAAGAGAT GGAAGGGGTG 
GTTAAAGAAC TTGCTGAAAA TAACCACATT TTAGAAAGGT TTGGCTCTTT AACCATGGAT 
GGTGGCCTTC GCAACGTTGA CTGTCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005268867.1
CDS	220..2409
Translation	MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL

Target ORF information:

RefSeq Version	XM_005268810.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TANK binding kinase 1 (TBK1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005268810.1

ORF Insert Sequence:

ATGCAGAGCA CTTCTAATCA TCTGTGGCTT TTATCTGATA TTTTAGGCCA AGGAGCTACT 
GCAAATGTCT TTCGTGGAAG ACATAAGAAA ACTGGTGATT TATTTGCTAT CAAAGTATTT 
AATAACATAA GCTTCCTTCG TCCAGTGGAT GTTCAAATGA GAGAATTTGA AGTGTTGAAA 
AAACTCAATC ACAAAAATAT TGTCAAATTA TTTGCTATTG AAGAGGAGAC AACAACAAGA 
CATAAAGTAC TTATTATGGA ATTTTGTCCA TGTGGGAGTT TATACACTGT TTTAGAAGAA 
CCTTCTAATG CCTATGGACT ACCAGAATCT GAATTCTTAA TTGTTTTGCG AGATGTGGTG 
GGTGGAATGA ATCATCTACG AGAGAATGGT ATAGTGCACC GTGATATCAA GCCAGGAAAT 
ATCATGCGTG TTATAGGGGA AGATGGACAG TCTGTGTACA AACTCACAGA TTTTGGTGCA 
GCTAGAGAAT TAGAAGATGA TGAGCAGTTT GTTTCTCTGT ATGGCACAGA AGAATATTTG 
CACCCTGATA TGTATGAGAG AGCAGTGCTA AGAAAAGATC ATCAGAAGAA ATATGGAGCA 
ACAGTTGATC TTTGGAGCAT TGGGGTAACA TTTTACCATG CAGCTACTGG ATCACTGCCA 
TTTAGACCCT TTGAAGGGCC TCGTAGGAAT AAAGAAGTGA TGTATAAAAT AATTACAGGA 
AAGCCTTCTG GTGCAATATC TGGAGTACAG AAAGCAGAAA ATGGACCAAT TGACTGGAGT 
GGAGACATGC CTGTTTCTTG CAGTCTTTCT CGGGGTCTTC AGGTTCTACT TACCCCTGTT 
CTTGCAAACA TCCTTGAAGC AGATCAGGAA AAGTGTTGGG GTTTTGACCA GTTTTTTGCA 
GAAACTAGTG ATATACTTCA CCGAATGGTA ATTCATGTTT TTTCGCTACA ACAAATGACA 
GCTCATAAGA TTTATATTCA TAGCTATAAT ACTGCTACTA TATTTCATGA ACTGGTATAT 
AAACAAACCA AAATTATTTC TTCAAATCAA GAACTTATCT ACGAAGGGCG ACGCTTAGTC 
TTAGAACCTG GAAGGCTGGC ACAACATTTC CCTAAAACTA CTGAGGAAAA CCCTATATTT 
GTAGTAAGCC GGGAACCTCT GAATACCATA GGATTAATAT ATGAAAAAAT TTCCCTCCCT 
AAAGTACATC CACGTTATGA TTTAGACGGG GATGCTAGCA TGGCTAAGGC AATAACAGGG 
GTTGTGTGTT ATGCCTGCAG AATTGCCAGT ACCTTACTGC TTTATCAGGA ATTAATGCGA 
AAGGGGATAC GATGGCTGAT TGAATTAATT AAAGATGATT ACAATGAAAC TGTTCACAAA 
AAGACAGAAG TTGTGATCAC ATTGGATTTC TGTATCAGAA ACATTGAAAA AACTGTGAAA 
GTATATGAAA AGTTGATGAA GATCAACCTG GAAGCGGCAG AGTTAGGTGA AATTTCAGAC 
ATACACACCA AATTGTTGAG ACTTTCCAGT TCTCAGGGAA CAATAGAAAC CAGTCTTCAG 
GATATCGACA GCAGATTATC TCCAGGTGGA TCACTGGCAG ACGCATGGGC ACATCAAGAA 
GGCACTCATC CGAAAGACAG AAATGTAGAA AAACTACAAG TCCTGTTAAA TTGCATGACA 
GAGATTTACT ATCAGTTCAA AAAAGACAAA GCAGAACGTA GATTAGCTTA TAATGAAGAA 
CAAATCCACA AATTTGATAA GCAAAAACTG TATTACCATG CCACAAAAGC TATGACGCAC 
TTTACAGATG AATGTGTTAA AAAGTATGAG GCATTTTTGA ATAAGTCAGA AGAATGGATA 
AGAAAGATGC TTCATCTTAG GAAACAGTTA TTATCGCTGA CTAATCAGTG TTTTGATATT 
GAAGAAGAAG TATCAAAATA TCAAGAATAT ACTAATGAGT TACAAGAAAC TCTGCCTCAG 
AAAATGTTTA CAGCTTCCAG TGGAATCAAA CATACCATGA CCCCAATTTA TCCAAGTTCT 
AACACATTAG TAGAAATGAC TCTTGGTATG AAGAAATTAA AGGAAGAGAT GGAAGGGGTG 
GTTAAAGAAC TTGCTGAAAA TAACCACATT TTAGAAAGGT TTGGCTCTTT AACCATGGAT 
GGTGGCCTTC GCAACGTTGA CTGTCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TBK1 ( XM_005268809.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005268866.1 Homo sapiens TANK binding kinase 1 (TBK1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu15095
Clone ID Related Accession (Same CDS sequence)	XM_005268810.1 , NM_013254.3 , XM_005268809.1 , NM_013254.4
Accession Version	XM_005268809.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase TBK1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGAGCA CTTCTAATCA TCTGTGGCTT TTATCTGATA TTTTAGGCCA AGGAGCTACT 
GCAAATGTCT TTCGTGGAAG ACATAAGAAA ACTGGTGATT TATTTGCTAT CAAAGTATTT 
AATAACATAA GCTTCCTTCG TCCAGTGGAT GTTCAAATGA GAGAATTTGA AGTGTTGAAA 
AAACTCAATC ACAAAAATAT TGTCAAATTA TTTGCTATTG AAGAGGAGAC AACAACAAGA 
CATAAAGTAC TTATTATGGA ATTTTGTCCA TGTGGGAGTT TATACACTGT TTTAGAAGAA 
CCTTCTAATG CCTATGGACT ACCAGAATCT GAATTCTTAA TTGTTTTGCG AGATGTGGTG 
GGTGGAATGA ATCATCTACG AGAGAATGGT ATAGTGCACC GTGATATCAA GCCAGGAAAT 
ATCATGCGTG TTATAGGGGA AGATGGACAG TCTGTGTACA AACTCACAGA TTTTGGTGCA 
GCTAGAGAAT TAGAAGATGA TGAGCAGTTT GTTTCTCTGT ATGGCACAGA AGAATATTTG 
CACCCTGATA TGTATGAGAG AGCAGTGCTA AGAAAAGATC ATCAGAAGAA ATATGGAGCA 
ACAGTTGATC TTTGGAGCAT TGGGGTAACA TTTTACCATG CAGCTACTGG ATCACTGCCA 
TTTAGACCCT TTGAAGGGCC TCGTAGGAAT AAAGAAGTGA TGTATAAAAT AATTACAGGA 
AAGCCTTCTG GTGCAATATC TGGAGTACAG AAAGCAGAAA ATGGACCAAT TGACTGGAGT 
GGAGACATGC CTGTTTCTTG CAGTCTTTCT CGGGGTCTTC AGGTTCTACT TACCCCTGTT 
CTTGCAAACA TCCTTGAAGC AGATCAGGAA AAGTGTTGGG GTTTTGACCA GTTTTTTGCA 
GAAACTAGTG ATATACTTCA CCGAATGGTA ATTCATGTTT TTTCGCTACA ACAAATGACA 
GCTCATAAGA TTTATATTCA TAGCTATAAT ACTGCTACTA TATTTCATGA ACTGGTATAT 
AAACAAACCA AAATTATTTC TTCAAATCAA GAACTTATCT ACGAAGGGCG ACGCTTAGTC 
TTAGAACCTG GAAGGCTGGC ACAACATTTC CCTAAAACTA CTGAGGAAAA CCCTATATTT 
GTAGTAAGCC GGGAACCTCT GAATACCATA GGATTAATAT ATGAAAAAAT TTCCCTCCCT 
AAAGTACATC CACGTTATGA TTTAGACGGG GATGCTAGCA TGGCTAAGGC AATAACAGGG 
GTTGTGTGTT ATGCCTGCAG AATTGCCAGT ACCTTACTGC TTTATCAGGA ATTAATGCGA 
AAGGGGATAC GATGGCTGAT TGAATTAATT AAAGATGATT ACAATGAAAC TGTTCACAAA 
AAGACAGAAG TTGTGATCAC ATTGGATTTC TGTATCAGAA ACATTGAAAA AACTGTGAAA 
GTATATGAAA AGTTGATGAA GATCAACCTG GAAGCGGCAG AGTTAGGTGA AATTTCAGAC 
ATACACACCA AATTGTTGAG ACTTTCCAGT TCTCAGGGAA CAATAGAAAC CAGTCTTCAG 
GATATCGACA GCAGATTATC TCCAGGTGGA TCACTGGCAG ACGCATGGGC ACATCAAGAA 
GGCACTCATC CGAAAGACAG AAATGTAGAA AAACTACAAG TCCTGTTAAA TTGCATGACA 
GAGATTTACT ATCAGTTCAA AAAAGACAAA GCAGAACGTA GATTAGCTTA TAATGAAGAA 
CAAATCCACA AATTTGATAA GCAAAAACTG TATTACCATG CCACAAAAGC TATGACGCAC 
TTTACAGATG AATGTGTTAA AAAGTATGAG GCATTTTTGA ATAAGTCAGA AGAATGGATA 
AGAAAGATGC TTCATCTTAG GAAACAGTTA TTATCGCTGA CTAATCAGTG TTTTGATATT 
GAAGAAGAAG TATCAAAATA TCAAGAATAT ACTAATGAGT TACAAGAAAC TCTGCCTCAG 
AAAATGTTTA CAGCTTCCAG TGGAATCAAA CATACCATGA CCCCAATTTA TCCAAGTTCT 
AACACATTAG TAGAAATGAC TCTTGGTATG AAGAAATTAA AGGAAGAGAT GGAAGGGGTG 
GTTAAAGAAC TTGCTGAAAA TAACCACATT TTAGAAAGGT TTGGCTCTTT AACCATGGAT 
GGTGGCCTTC GCAACGTTGA CTGTCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005268866.1
CDS	238..2427
Translation	MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL

Target ORF information:

RefSeq Version	XM_005268809.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TANK binding kinase 1 (TBK1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005268809.1

ORF Insert Sequence:

ATGCAGAGCA CTTCTAATCA TCTGTGGCTT TTATCTGATA TTTTAGGCCA AGGAGCTACT 
GCAAATGTCT TTCGTGGAAG ACATAAGAAA ACTGGTGATT TATTTGCTAT CAAAGTATTT 
AATAACATAA GCTTCCTTCG TCCAGTGGAT GTTCAAATGA GAGAATTTGA AGTGTTGAAA 
AAACTCAATC ACAAAAATAT TGTCAAATTA TTTGCTATTG AAGAGGAGAC AACAACAAGA 
CATAAAGTAC TTATTATGGA ATTTTGTCCA TGTGGGAGTT TATACACTGT TTTAGAAGAA 
CCTTCTAATG CCTATGGACT ACCAGAATCT GAATTCTTAA TTGTTTTGCG AGATGTGGTG 
GGTGGAATGA ATCATCTACG AGAGAATGGT ATAGTGCACC GTGATATCAA GCCAGGAAAT 
ATCATGCGTG TTATAGGGGA AGATGGACAG TCTGTGTACA AACTCACAGA TTTTGGTGCA 
GCTAGAGAAT TAGAAGATGA TGAGCAGTTT GTTTCTCTGT ATGGCACAGA AGAATATTTG 
CACCCTGATA TGTATGAGAG AGCAGTGCTA AGAAAAGATC ATCAGAAGAA ATATGGAGCA 
ACAGTTGATC TTTGGAGCAT TGGGGTAACA TTTTACCATG CAGCTACTGG ATCACTGCCA 
TTTAGACCCT TTGAAGGGCC TCGTAGGAAT AAAGAAGTGA TGTATAAAAT AATTACAGGA 
AAGCCTTCTG GTGCAATATC TGGAGTACAG AAAGCAGAAA ATGGACCAAT TGACTGGAGT 
GGAGACATGC CTGTTTCTTG CAGTCTTTCT CGGGGTCTTC AGGTTCTACT TACCCCTGTT 
CTTGCAAACA TCCTTGAAGC AGATCAGGAA AAGTGTTGGG GTTTTGACCA GTTTTTTGCA 
GAAACTAGTG ATATACTTCA CCGAATGGTA ATTCATGTTT TTTCGCTACA ACAAATGACA 
GCTCATAAGA TTTATATTCA TAGCTATAAT ACTGCTACTA TATTTCATGA ACTGGTATAT 
AAACAAACCA AAATTATTTC TTCAAATCAA GAACTTATCT ACGAAGGGCG ACGCTTAGTC 
TTAGAACCTG GAAGGCTGGC ACAACATTTC CCTAAAACTA CTGAGGAAAA CCCTATATTT 
GTAGTAAGCC GGGAACCTCT GAATACCATA GGATTAATAT ATGAAAAAAT TTCCCTCCCT 
AAAGTACATC CACGTTATGA TTTAGACGGG GATGCTAGCA TGGCTAAGGC AATAACAGGG 
GTTGTGTGTT ATGCCTGCAG AATTGCCAGT ACCTTACTGC TTTATCAGGA ATTAATGCGA 
AAGGGGATAC GATGGCTGAT TGAATTAATT AAAGATGATT ACAATGAAAC TGTTCACAAA 
AAGACAGAAG TTGTGATCAC ATTGGATTTC TGTATCAGAA ACATTGAAAA AACTGTGAAA 
GTATATGAAA AGTTGATGAA GATCAACCTG GAAGCGGCAG AGTTAGGTGA AATTTCAGAC 
ATACACACCA AATTGTTGAG ACTTTCCAGT TCTCAGGGAA CAATAGAAAC CAGTCTTCAG 
GATATCGACA GCAGATTATC TCCAGGTGGA TCACTGGCAG ACGCATGGGC ACATCAAGAA 
GGCACTCATC CGAAAGACAG AAATGTAGAA AAACTACAAG TCCTGTTAAA TTGCATGACA 
GAGATTTACT ATCAGTTCAA AAAAGACAAA GCAGAACGTA GATTAGCTTA TAATGAAGAA 
CAAATCCACA AATTTGATAA GCAAAAACTG TATTACCATG CCACAAAAGC TATGACGCAC 
TTTACAGATG AATGTGTTAA AAAGTATGAG GCATTTTTGA ATAAGTCAGA AGAATGGATA 
AGAAAGATGC TTCATCTTAG GAAACAGTTA TTATCGCTGA CTAATCAGTG TTTTGATATT 
GAAGAAGAAG TATCAAAATA TCAAGAATAT ACTAATGAGT TACAAGAAAC TCTGCCTCAG 
AAAATGTTTA CAGCTTCCAG TGGAATCAAA CATACCATGA CCCCAATTTA TCCAAGTTCT 
AACACATTAG TAGAAATGAC TCTTGGTATG AAGAAATTAA AGGAAGAGAT GGAAGGGGTG 
GTTAAAGAAC TTGCTGAAAA TAACCACATT TTAGAAAGGT TTGGCTCTTT AACCATGGAT 
GGTGGCCTTC GCAACGTTGA CTGTCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genomic Organization of TBK1 Copy Number Variations in Glaucoma Patients.
Journal of glaucoma26(12)1063-1067(2017 Dec)
DeLuca AP,Alward WLM,Liebmann J,Ritch R,Kawase K,Kwon YH,Robin AL,Stone EM,Scheetz TE,Fingert JH

USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.
The Journal of experimental medicine214(12)3553-3563(2017 Dec)
Yu Z,Song H,Jia M,Zhang J,Wang W,Li Q,Zhang L,Zhao W

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TBK1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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