Gene Symbol | CHMP4A |
Entrez Gene ID | 29082 |
Full Name | charged multivesicular body protein 4A |
Synonyms | C14orf123,CHMP4,CHMP4B,HSPC134,SHAX2,SNF7,SNF7-1,VPS32-1,VPS32A |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]. |
Disorder MIM: |