GRIN2D cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GRIN2D
Entrez Gene ID	2906
Full Name	glutamate ionotropic receptor NMDA type subunit 2D
Synonyms	EB11,EIEE46,GluN2D,NMDAR2D,NR2D
General protein information	Preferred Names glutamate ionotropic receptor NMDA type subunit 2D Names glutamate receptor ionotropic, NMDA 2D N-methyl D-aspartate receptor subtype 2D N-methyl-d-aspartate receptor subunit 2D estrogen receptor binding CpG island glutamate [NMDA] receptor subunit epsilon-4 glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010].
Disorder MIM:	602717
Disorder Html:	Epileptic encephalopathy, early infantile, 46, 617162 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011526872.1	XP_011525174.1	glutamate receptor ionotropic, NMDA 2D isoform X1
NM_000836.2	NP_000827.2	glutamate receptor ionotropic, NMDA 2D precursor

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012429	XP_314428.4
Xenopus tropicalis (tropical clawed frog)	grin2d	XP_002935032.1
Homo sapiens (human)	GRIN2D	NP_000827.2
Drosophila melanogaster (fruit fly)	Nmdar2	NP_001162637.1
Canis lupus familiaris (dog)	GRIN2D	XP_005616409.1
Mus musculus (house mouse)	Grin2d	NP_032198.2
Rattus norvegicus (Norway rat)	Grin2d	NP_073634.1
Bos taurus (cattle)	GRIN2D	XP_002695241.2
Caenorhabditis elegans (roundworm)	nmr-2	NP_001256640.1

Gene Ontology
Bibliography

Related articles in PubMed

The excitotoxity of NMDA receptor NR2D subtype mediates human fetal lung fibroblasts proliferation and collagen production.
Wang M, Luo Z, Yue Y, Wang Y, Wu S, Cao C, Liao Z, Yu X, Yue S
Toxicology in vitro : an international journal published in association with BIBRA4647-57(2018 Feb)

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.
Yu Y, Lin Y, Takasaki Y, Wang C, Kimura H, Xing J, Ishizuka K, Toyama M, Kushima I, Mori D, Arioka Y, Uno Y, Shiino T, Nakamura Y, Okada T, Morikawa M, Ikeda M, Iwata N, Okahisa Y, Takaki M, Sakamoto S, Someya T, Egawa J, Usami M, Kodaira M, Yoshimi A, Oya-Ito T, Aleksic B, Ohno K, Ozaki N
Translational psychiatry8(1)12(2018 Jan)

AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women.
Bhandage AK, Jin Z, Hellgren C, Korol SV, Nowak K, Williamsson L, Sundstr?m-Poromaa I, Birnir B
Journal of neuroimmunology30551-58(2017 Apr)

GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.
Li D, Yuan H, Ortiz-Gonzalez XR, Marsh ED, Tian L, McCormick EM, Kosobucki GJ, Chen W, Schulien AJ, Chiavacci R, Tankovic A, Naase C, Brueckner F, von St?lpnagel-Steinbeis C, Hu C, Kusumoto H, Hedrich UB, Elsen G, H?rtnagel K, Aizenman E, Lemke JR, Hakonarson H, Traynelis SF, Falk MJ
American journal of human genetics99(4)802-816(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study showed that the higher GluN2D mRNA level in healthy but not in depressed pregnant women as compared to non-pregnant individuals.
Title: AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women.

GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers
Title: GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.

After 7 days of chronic alcohol exposure, there are significant increases in mRNA expression of GRIN2D in cultured neurons derived from alcoholic subjects, but not in cultures from nonalcoholics.
Title: Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro.

Absence of truncating mutation in GRIN1 and GRIN2D genes in patients with autism spectrum disorder and schizophrenia and controls.
Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.

In microsatellite instable and microsatellite and chromosomally stable cancers, CIMP and BRAF/KRAS mutations are similarly distributed indicating common mechanisms of tumor initiation or progression in the molecular pathogenesis.
Title: [Chromosomal instability, microsatellite instability and CpG island methylator phenotype: roles in small intestinal carcinogenesis].

The following GRIN2D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GRIN2D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30647	NM_000836.2 Latest version!	Homo sapiens glutamate ionotropic receptor NMDA type subunit 2D (GRIN2D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$727.30 $1039.00
OHu30647	XM_011526872.1 Latest version!	Homo sapiens glutamate ionotropic receptor NMDA type subunit 2D (GRIN2D), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$727.30 $1039.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GRIN2D ( NM_000836.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000827.2 Homo sapiens glutamate ionotropic receptor NMDA type subunit 2D (GRIN2D), mRNA.

Price & Availability↑

CloneID	OHu30647
Clone ID Related Accession (Same CDS sequence)	XM_011526872.1 , NM_000836.2
Accession Version	NM_000836.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4011bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	glutamate receptor ionotropic, NMDA 2D precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U77783.1, AB209292.1 and AW139866.1. This sequence is a reference standard in the RefSeqGene project. On Jul 26, 2007 this sequence version replaced NM_000836.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U77783.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGCGGCG CCGGTGGCCC CCGCGGCCCT CGGGGCCCCG CTAAGATGCT GCTGCTGCTG 
GCGCTGGCCT GCGCCAGCCC GTTCCCGGAG GAGGCGCCGG GGCCGGGCGG GGCCGGTGGG 
CCCGGCGGCG GCCTCGGCGG GGCGCGGCCG CTCAACGTGG CGCTCGTGTT CTCGGGGCCC 
GCGTACGCGG CCGAGGCGGC ACGCCTGGGC CCGGCCGTGG CGGCGGCGGT GCGCAGCCCG 
GGCCTAGACG TGCGGCCCGT GGCGCTGGTG CTCAACGGCT CGGACCCGCG CAGCCTCGTG 
CTGCAGCTCT GCGACCTGCT GTCGGGGTTG CGCGTGCACG GCGTGGTCTT CGAAGACGAC 
TCGCGCGCGC CCGCCGTCGC GCCCATCCTC GACTTCCTGT CGGCGCAGAC CTCGCTGCCC 
ATCGTGGCCG TGCACGGCGG CGCCGCGCTC GTGCTCACGC CCAAGGAGAA GGGCTCCACC 
TTCCTGCAGC TGGGCTCTTC CACCGAGCAA CAGCTTCAGG TCATCTTTGA GGTGCTGGAG 
GAGTATGACT GGACGTCCTT TGTAGCCGTG ACCACTCGTG CCCCTGGCCA CCGGGCCTTC 
CTGTCCTACA TTGAGGTGCT GACTGACGGT AGTCTGGTGG GCTGGGAGCA CCGCGGAGCG 
CTGACGCTGG ACCCTGGGGC GGGCGAGGCC GTGCTCAGTG CCCAGCTCCG CAGTGTCAGC 
GCGCAGATCC GCCTGCTCTT CTGCGCCCGA GAGGAGGCCG AGCCCGTGTT CCGCGCAGCT 
GAGGAGGCTG GCCTCACTGG ATCTGGCTAC GTCTGGTTCA TGGTGGGGCC CCAGCTGGCT 
GGAGGCGGGG GCTCTGGGGC CCCTGGTGAG CCCCCTCTTC TGCCAGGAGG CGCCCCCCTG 
CCTGCCGGGC TGTTTGCAGT GCGCTCGGCT GGCTGGCGGG ATGACCTGGC TCGGCGAGTG 
GCAGCTGGCG TGGCCGTAGT GGCCAGAGGT GCCCAGGCCC TGCTGCGTGA TTATGGTTTC 
CTTCCTGAGC TCGGCCACGA CTGTCGCGCC CAGAACCGCA CCCACCGCGG CGAGAGTCTG 
CATAGGTACT TCATGAACAT CACGTGGGAT AACCGGGATT ACTCCTTCAA TGAGGACGGC 
TTCCTAGTGA ACCCCTCCCT GGTGGTCATC TCCCTCACCA GAGACAGGAC GTGGGAGGTG 
GTGGGCAGCT GGGAGCAGCA GACGCTCCGC CTCAAGTACC CGCTGTGGTC CCGCTATGGT 
CGCTTCCTGC AGCCAGTGGA CGACACGCAG CACCTCACGG TGGCCACGCT GGAGGAAAGG 
CCGTTTGTCA TCGTGGAGCC TGCAGACCCT ATCAGCGGCA CCTGCATCCG AGACTCCGTC 
CCCTGCCGGA GCCAGCTCAA CCGAACCCAC AGCCCTCCAC CGGATGCCCC CCGCCCGGAA 
AAGCGCTGCT GCAAGGGTTT CTGCATCGAC ATTCTGAAGC GGCTGGCGCA TACCATCGGC 
TTCAGCTACG ACCTCTACCT GGTCACCAAT GGCAAGCACG GAAAGAAGAT CGATGGCGTC 
TGGAACGGCA TGATCGGGGA GGTGTTCTAC CAGCGCGCAG ACATGGCCAT CGGCTCCCTC 
ACCATCAACG AGGAGCGCTC CGAGATCGTG GACTTCTCCG TCCCCTTCGT GGAGACCGGC 
ATCAGCGTCA TGGTGGCGCG CAGCAATGGC ACGGTGTCCC CCTCGGCCTT CCTCGAGCCC 
TACAGCCCCG CCGTGTGGGT GATGATGTTC GTCATGTGCC TCACTGTGGT CGCCGTCACT 
GTTTTCATCT TCGAGTACCT CAGTCCTGTT GGTTACAACC GCAGCCTGGC CACGGGCAAG 
CGCCCTGGCG GTTCAACCTT CACCATTGGG AAATCCATCT GGCTGCTCTG GGCCCTGGTG 
TTCAATAATT CGGTGCCCGT GGAGAACCCC CGGGGAACCA CCAGCAAAAT CATGGTGCTG 
GTGTGGGCCT TCTTCGCCGT CATCTTCCTC GCCAGCTACA CAGCCAACCT GGCCGCCTTC 
ATGATCCAGG AGGAGTACGT GGATACTGTG TCTGGGCTCA GTGACCGCAA GTTCCAGAGG 
CCCCAGGAGC AGTACCCGCC CCTGAAGTTT GGGACCGTGC CCAACGGCTC CACGGAGAAG 
AACATCCGCA GCAACTATCC CGACATGCAC AGCTACATGG TGCGCTACAA CCAGCCCCGC 
GTAGAGGAAG CGCTCACTCA GCTCAAGGCA GGGAAGCTGG ACGCCTTCAT CTACGATGCT 
GCAGTGCTCA ATTACATGGC CCGCAAGGAC GAGGGCTGCA AGCTTGTCAC CATCGGCTCC 
GGCAAGGTCT TCGCCACGAC AGGCTATGGC ATCGCCCTGC ACAAGGGCTC CCGCTGGAAG 
CGGCCCATCG ACCTGGCGTT GCTGCAGTTC CTGGGGGATG ATGAGATCGA GATGCTGGAG 
CGGCTGTGGC TCTCTGGGAT CTGCCACAAT GACAAAATCG AGGTGATGAG CAGCAAGCTG 
GACATCGACA ACATGGCGGG CGTCTTCTAC ATGCTCCTGG TGGCCATGGG CCTGTCCCTG 
CTGGTCTTCG CCTGGGAGCA CCTGGTGTAC TGGCGCCTGC GGCACTGCCT GGGGCCCACC 
CACCGCATGG ACTTCCTGCT GGCCTTCTCC AGGGGCATGT ACAGCTGCTG CAGCGCTGAG 
GCCGCCCCAC CGCCCGCCAA GCCCCCGCCG CCGCCACAGC CCCTGCCCAG CCCCGCGTAC 
CCCGCGCCGC GGCCGGCTCC CGGGCCCGCA CCTTTCGTGC CCCGCGAGCG CGCCTCAGTG 
GACCGCTGGC GCCGGACCAA GGGCGCGGGG CCGCCGGGGG GCGCGGGCCT GGCCGACGGC 
TTCCACCGCT ACTACGGCCC CATCGAGCCG CAGGGCCTAG GCCTCGGCCT GGGCGAAGCG 
CGCGCGGCAC CGCGGGGCGC AGCCGGGCGC CCGCTGTCCC CGCCGGCCGC TCAGCCCCCG 
CAGAAGCCGC CGCCCTCCTA TTTCGCCATC GTACGCGACA AGGAGCCAGC CGAGCCCCCC 
GCCGGCGCCT TCCCCGGCTT CCCGTCGCCG CCCGCGCCCC CCGCCGCCGC GGCCACCGCC 
GTCGGGCCGC CACTCTGCCG CTTGGCCTTC GAGGACGAGA GCCCGCCGGC GCCCGCGCGG 
TGGCCGCGCT CGGACCCCGA GAGCCAACCC CTGCTGGGGC CAGGCGCGGG CGGCGCGGGG 
GGCACGGGGG GCGCAGGCGG AGGAGCCCCG GCCGCTCCGC CCCCGTGCCG CGCCGCGCCG 
CCCCCGTGCC CTTACCTCGA TCTCGAGCCG TCGCCGTCGG ACTCGGAGGA CTCGGAGAGC 
CTGGGCGGCG CGTCGCTGGG CGGCCTGGAG CCCTGGTGGT TCGCCGACTT CCCTTACCCG 
TATGCCGAGC GCCTCGGGCC GCCGCCCGGC CGCTACTGGT CGGTCGACAA GCTCGGGGGC 
TGGCGCGCCG GGAGCTGGGA CTACCTGCCC CCGCGCAGCG GTCCGGCCGC CTGGCACTGT 
CGGCACTGCG CCAGCCTGGA GCTGCTGCCG CCGCCGCGCC ATCTCAGCTG CTCGCACGAT 
GGCCTGGACG GCGGCTGGTG GGCGCCACCG CCTCCACCCT GGGCCGCCGG GCCCCTGCCC 
CGACGCCGGG CCCGCTGCGG GTGCCCGCGG TCGCACCCGC ACCGCCCGCG GGCCTCGCAC 
CGCACGCCCG CCGCCGCCGC GCCCCACCAC CACAGGCACC GGCGCGCCGC TGGGGGCTGG 
GACCTCCCGC CGCCCGCGCC CACCTCGCGC TCGCTCGAGG ACCTCAGCTC GTGCCCTCGC 
GCCGCCCCTG CGCGCAGGCT TACCGGGCCC TCCCGCCACG CTCGCAGGTG TCCGCACGCC 
GCGCACTGGG GGCCGCCGCT GCCCACAGCT TCCCACCGGA GACACCGGGG CGGGGACCTG 
GGCACCCGCA GGGGCTCGGC GCACTTCTCT AGCCTCGAGT CCGAGGTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000827.2
CDS	89..4099
Translation	MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFSSLESEV

Target ORF information:

RefSeq Version	NM_000836.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate ionotropic receptor NMDA type subunit 2D (GRIN2D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000836.2

ORF Insert Sequence:

ATGCGCGGCG CCGGTGGCCC CCGCGGCCCT CGGGGCCCCG CTAAGATGCT GCTGCTGCTG 
GCGCTGGCCT GCGCCAGCCC GTTCCCGGAG GAGGCGCCGG GGCCGGGCGG GGCCGGTGGG 
CCCGGCGGCG GCCTCGGCGG GGCGCGGCCG CTCAACGTGG CGCTCGTGTT CTCGGGGCCC 
GCGTACGCGG CCGAGGCGGC ACGCCTGGGC CCGGCCGTGG CGGCGGCGGT GCGCAGCCCG 
GGCCTAGACG TGCGGCCCGT GGCGCTGGTG CTCAACGGCT CGGACCCGCG CAGCCTCGTG 
CTGCAGCTCT GCGACCTGCT GTCGGGGTTG CGCGTGCACG GCGTGGTCTT CGAAGACGAC 
TCGCGCGCGC CCGCCGTCGC GCCCATCCTC GACTTCCTGT CGGCGCAGAC CTCGCTGCCC 
ATCGTGGCCG TGCACGGCGG CGCCGCGCTC GTGCTCACGC CCAAGGAGAA GGGCTCCACC 
TTCCTGCAGC TGGGCTCTTC CACCGAGCAA CAGCTTCAGG TCATCTTTGA GGTGCTGGAG 
GAGTATGACT GGACGTCCTT TGTAGCCGTG ACCACTCGTG CCCCTGGCCA CCGGGCCTTC 
CTGTCCTACA TTGAGGTGCT GACTGACGGT AGTCTGGTGG GCTGGGAGCA CCGCGGAGCG 
CTGACGCTGG ACCCTGGGGC GGGCGAGGCC GTGCTCAGTG CCCAGCTCCG CAGTGTCAGC 
GCGCAGATCC GCCTGCTCTT CTGCGCCCGA GAGGAGGCCG AGCCCGTGTT CCGCGCAGCT 
GAGGAGGCTG GCCTCACTGG ATCTGGCTAC GTCTGGTTCA TGGTGGGGCC CCAGCTGGCT 
GGAGGCGGGG GCTCTGGGGC CCCTGGTGAG CCCCCTCTTC TGCCAGGAGG CGCCCCCCTG 
CCTGCCGGGC TGTTTGCAGT GCGCTCGGCT GGCTGGCGGG ATGACCTGGC TCGGCGAGTG 
GCAGCTGGCG TGGCCGTAGT GGCCAGAGGT GCCCAGGCCC TGCTGCGTGA TTATGGTTTC 
CTTCCTGAGC TCGGCCACGA CTGTCGCGCC CAGAACCGCA CCCACCGCGG CGAGAGTCTG 
CATAGGTACT TCATGAACAT CACGTGGGAT AACCGGGATT ACTCCTTCAA TGAGGACGGC 
TTCCTAGTGA ACCCCTCCCT GGTGGTCATC TCCCTCACCA GAGACAGGAC GTGGGAGGTG 
GTGGGCAGCT GGGAGCAGCA GACGCTCCGC CTCAAGTACC CGCTGTGGTC CCGCTATGGT 
CGCTTCCTGC AGCCAGTGGA CGACACGCAG CACCTCACGG TGGCCACGCT GGAGGAAAGG 
CCGTTTGTCA TCGTGGAGCC TGCAGACCCT ATCAGCGGCA CCTGCATCCG AGACTCCGTC 
CCCTGCCGGA GCCAGCTCAA CCGAACCCAC AGCCCTCCAC CGGATGCCCC CCGCCCGGAA 
AAGCGCTGCT GCAAGGGTTT CTGCATCGAC ATTCTGAAGC GGCTGGCGCA TACCATCGGC 
TTCAGCTACG ACCTCTACCT GGTCACCAAT GGCAAGCACG GAAAGAAGAT CGATGGCGTC 
TGGAACGGCA TGATCGGGGA GGTGTTCTAC CAGCGCGCAG ACATGGCCAT CGGCTCCCTC 
ACCATCAACG AGGAGCGCTC CGAGATCGTG GACTTCTCCG TCCCCTTCGT GGAGACCGGC 
ATCAGCGTCA TGGTGGCGCG CAGCAATGGC ACGGTGTCCC CCTCGGCCTT CCTCGAGCCC 
TACAGCCCCG CCGTGTGGGT GATGATGTTC GTCATGTGCC TCACTGTGGT CGCCGTCACT 
GTTTTCATCT TCGAGTACCT CAGTCCTGTT GGTTACAACC GCAGCCTGGC CACGGGCAAG 
CGCCCTGGCG GTTCAACCTT CACCATTGGG AAATCCATCT GGCTGCTCTG GGCCCTGGTG 
TTCAATAATT CGGTGCCCGT GGAGAACCCC CGGGGAACCA CCAGCAAAAT CATGGTGCTG 
GTGTGGGCCT TCTTCGCCGT CATCTTCCTC GCCAGCTACA CAGCCAACCT GGCCGCCTTC 
ATGATCCAGG AGGAGTACGT GGATACTGTG TCTGGGCTCA GTGACCGCAA GTTCCAGAGG 
CCCCAGGAGC AGTACCCGCC CCTGAAGTTT GGGACCGTGC CCAACGGCTC CACGGAGAAG 
AACATCCGCA GCAACTATCC CGACATGCAC AGCTACATGG TGCGCTACAA CCAGCCCCGC 
GTAGAGGAAG CGCTCACTCA GCTCAAGGCA GGGAAGCTGG ACGCCTTCAT CTACGATGCT 
GCAGTGCTCA ATTACATGGC CCGCAAGGAC GAGGGCTGCA AGCTTGTCAC CATCGGCTCC 
GGCAAGGTCT TCGCCACGAC AGGCTATGGC ATCGCCCTGC ACAAGGGCTC CCGCTGGAAG 
CGGCCCATCG ACCTGGCGTT GCTGCAGTTC CTGGGGGATG ATGAGATCGA GATGCTGGAG 
CGGCTGTGGC TCTCTGGGAT CTGCCACAAT GACAAAATCG AGGTGATGAG CAGCAAGCTG 
GACATCGACA ACATGGCGGG CGTCTTCTAC ATGCTCCTGG TGGCCATGGG CCTGTCCCTG 
CTGGTCTTCG CCTGGGAGCA CCTGGTGTAC TGGCGCCTGC GGCACTGCCT GGGGCCCACC 
CACCGCATGG ACTTCCTGCT GGCCTTCTCC AGGGGCATGT ACAGCTGCTG CAGCGCTGAG 
GCCGCCCCAC CGCCCGCCAA GCCCCCGCCG CCGCCACAGC CCCTGCCCAG CCCCGCGTAC 
CCCGCGCCGC GGCCGGCTCC CGGGCCCGCA CCTTTCGTGC CCCGCGAGCG CGCCTCAGTG 
GACCGCTGGC GCCGGACCAA GGGCGCGGGG CCGCCGGGGG GCGCGGGCCT GGCCGACGGC 
TTCCACCGCT ACTACGGCCC CATCGAGCCG CAGGGCCTAG GCCTCGGCCT GGGCGAAGCG 
CGCGCGGCAC CGCGGGGCGC AGCCGGGCGC CCGCTGTCCC CGCCGGCCGC TCAGCCCCCG 
CAGAAGCCGC CGCCCTCCTA TTTCGCCATC GTACGCGACA AGGAGCCAGC CGAGCCCCCC 
GCCGGCGCCT TCCCCGGCTT CCCGTCGCCG CCCGCGCCCC CCGCCGCCGC GGCCACCGCC 
GTCGGGCCGC CACTCTGCCG CTTGGCCTTC GAGGACGAGA GCCCGCCGGC GCCCGCGCGG 
TGGCCGCGCT CGGACCCCGA GAGCCAACCC CTGCTGGGGC CAGGCGCGGG CGGCGCGGGG 
GGCACGGGGG GCGCAGGCGG AGGAGCCCCG GCCGCTCCGC CCCCGTGCCG CGCCGCGCCG 
CCCCCGTGCC CTTACCTCGA TCTCGAGCCG TCGCCGTCGG ACTCGGAGGA CTCGGAGAGC 
CTGGGCGGCG CGTCGCTGGG CGGCCTGGAG CCCTGGTGGT TCGCCGACTT CCCTTACCCG 
TATGCCGAGC GCCTCGGGCC GCCGCCCGGC CGCTACTGGT CGGTCGACAA GCTCGGGGGC 
TGGCGCGCCG GGAGCTGGGA CTACCTGCCC CCGCGCAGCG GTCCGGCCGC CTGGCACTGT 
CGGCACTGCG CCAGCCTGGA GCTGCTGCCG CCGCCGCGCC ATCTCAGCTG CTCGCACGAT 
GGCCTGGACG GCGGCTGGTG GGCGCCACCG CCTCCACCCT GGGCCGCCGG GCCCCTGCCC 
CGACGCCGGG CCCGCTGCGG GTGCCCGCGG TCGCACCCGC ACCGCCCGCG GGCCTCGCAC 
CGCACGCCCG CCGCCGCCGC GCCCCACCAC CACAGGCACC GGCGCGCCGC TGGGGGCTGG 
GACCTCCCGC CGCCCGCGCC CACCTCGCGC TCGCTCGAGG ACCTCAGCTC GTGCCCTCGC 
GCCGCCCCTG CGCGCAGGCT TACCGGGCCC TCCCGCCACG CTCGCAGGTG TCCGCACGCC 
GCGCACTGGG GGCCGCCGCT GCCCACAGCT TCCCACCGGA GACACCGGGG CGGGGACCTG 
GGCACCCGCA GGGGCTCGGC GCACTTCTCT AGCCTCGAGT CCGAGGTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRIN2D ( XM_011526872.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525174.1 Homo sapiens glutamate ionotropic receptor NMDA type subunit 2D (GRIN2D), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu30647
Clone ID Related Accession (Same CDS sequence)	XM_011526872.1 , NM_000836.2
Accession Version	XM_011526872.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4011bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	glutamate receptor ionotropic, NMDA 2D isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCGGCG CCGGTGGCCC CCGCGGCCCT CGGGGCCCCG CTAAGATGCT GCTGCTGCTG 
GCGCTGGCCT GCGCCAGCCC GTTCCCGGAG GAGGCGCCGG GGCCGGGCGG GGCCGGTGGG 
CCCGGCGGCG GCCTCGGCGG GGCGCGGCCG CTCAACGTGG CGCTCGTGTT CTCGGGGCCC 
GCGTACGCGG CCGAGGCGGC ACGCCTGGGC CCGGCCGTGG CGGCGGCGGT GCGCAGCCCG 
GGCCTAGACG TGCGGCCCGT GGCGCTGGTG CTCAACGGCT CGGACCCGCG CAGCCTCGTG 
CTGCAGCTCT GCGACCTGCT GTCGGGGTTG CGCGTGCACG GCGTGGTCTT CGAAGACGAC 
TCGCGCGCGC CCGCCGTCGC GCCCATCCTC GACTTCCTGT CGGCGCAGAC CTCGCTGCCC 
ATCGTGGCCG TGCACGGCGG CGCCGCGCTC GTGCTCACGC CCAAGGAGAA GGGCTCCACC 
TTCCTGCAGC TGGGCTCTTC CACCGAGCAA CAGCTTCAGG TCATCTTTGA GGTGCTGGAG 
GAGTATGACT GGACGTCCTT TGTAGCCGTG ACCACTCGTG CCCCTGGCCA CCGGGCCTTC 
CTGTCCTACA TTGAGGTGCT GACTGACGGT AGTCTGGTGG GCTGGGAGCA CCGCGGAGCG 
CTGACGCTGG ACCCTGGGGC GGGCGAGGCC GTGCTCAGTG CCCAGCTCCG CAGTGTCAGC 
GCGCAGATCC GCCTGCTCTT CTGCGCCCGA GAGGAGGCCG AGCCCGTGTT CCGCGCAGCT 
GAGGAGGCTG GCCTCACTGG ATCTGGCTAC GTCTGGTTCA TGGTGGGGCC CCAGCTGGCT 
GGAGGCGGGG GCTCTGGGGC CCCTGGTGAG CCCCCTCTTC TGCCAGGAGG CGCCCCCCTG 
CCTGCCGGGC TGTTTGCAGT GCGCTCGGCT GGCTGGCGGG ATGACCTGGC TCGGCGAGTG 
GCAGCTGGCG TGGCCGTAGT GGCCAGAGGT GCCCAGGCCC TGCTGCGTGA TTATGGTTTC 
CTTCCTGAGC TCGGCCACGA CTGTCGCGCC CAGAACCGCA CCCACCGCGG CGAGAGTCTG 
CATAGGTACT TCATGAACAT CACGTGGGAT AACCGGGATT ACTCCTTCAA TGAGGACGGC 
TTCCTAGTGA ACCCCTCCCT GGTGGTCATC TCCCTCACCA GAGACAGGAC GTGGGAGGTG 
GTGGGCAGCT GGGAGCAGCA GACGCTCCGC CTCAAGTACC CGCTGTGGTC CCGCTATGGT 
CGCTTCCTGC AGCCAGTGGA CGACACGCAG CACCTCACGG TGGCCACGCT GGAGGAAAGG 
CCGTTTGTCA TCGTGGAGCC TGCAGACCCT ATCAGCGGCA CCTGCATCCG AGACTCCGTC 
CCCTGCCGGA GCCAGCTCAA CCGAACCCAC AGCCCTCCAC CGGATGCCCC CCGCCCGGAA 
AAGCGCTGCT GCAAGGGTTT CTGCATCGAC ATTCTGAAGC GGCTGGCGCA TACCATCGGC 
TTCAGCTACG ACCTCTACCT GGTCACCAAT GGCAAGCACG GAAAGAAGAT CGATGGCGTC 
TGGAACGGCA TGATCGGGGA GGTGTTCTAC CAGCGCGCAG ACATGGCCAT CGGCTCCCTC 
ACCATCAACG AGGAGCGCTC CGAGATCGTG GACTTCTCCG TCCCCTTCGT GGAGACCGGC 
ATCAGCGTCA TGGTGGCGCG CAGCAATGGC ACGGTGTCCC CCTCGGCCTT CCTCGAGCCC 
TACAGCCCCG CCGTGTGGGT GATGATGTTC GTCATGTGCC TCACTGTGGT CGCCGTCACT 
GTTTTCATCT TCGAGTACCT CAGTCCTGTT GGTTACAACC GCAGCCTGGC CACGGGCAAG 
CGCCCTGGCG GTTCAACCTT CACCATTGGG AAATCCATCT GGCTGCTCTG GGCCCTGGTG 
TTCAATAATT CGGTGCCCGT GGAGAACCCC CGGGGAACCA CCAGCAAAAT CATGGTGCTG 
GTGTGGGCCT TCTTCGCCGT CATCTTCCTC GCCAGCTACA CAGCCAACCT GGCCGCCTTC 
ATGATCCAGG AGGAGTACGT GGATACTGTG TCTGGGCTCA GTGACCGCAA GTTCCAGAGG 
CCCCAGGAGC AGTACCCGCC CCTGAAGTTT GGGACCGTGC CCAACGGCTC CACGGAGAAG 
AACATCCGCA GCAACTATCC CGACATGCAC AGCTACATGG TGCGCTACAA CCAGCCCCGC 
GTAGAGGAAG CGCTCACTCA GCTCAAGGCA GGGAAGCTGG ACGCCTTCAT CTACGATGCT 
GCAGTGCTCA ATTACATGGC CCGCAAGGAC GAGGGCTGCA AGCTTGTCAC CATCGGCTCC 
GGCAAGGTCT TCGCCACGAC AGGCTATGGC ATCGCCCTGC ACAAGGGCTC CCGCTGGAAG 
CGGCCCATCG ACCTGGCGTT GCTGCAGTTC CTGGGGGATG ATGAGATCGA GATGCTGGAG 
CGGCTGTGGC TCTCTGGGAT CTGCCACAAT GACAAAATCG AGGTGATGAG CAGCAAGCTG 
GACATCGACA ACATGGCGGG CGTCTTCTAC ATGCTCCTGG TGGCCATGGG CCTGTCCCTG 
CTGGTCTTCG CCTGGGAGCA CCTGGTGTAC TGGCGCCTGC GGCACTGCCT GGGGCCCACC 
CACCGCATGG ACTTCCTGCT GGCCTTCTCC AGGGGCATGT ACAGCTGCTG CAGCGCTGAG 
GCCGCCCCAC CGCCCGCCAA GCCCCCGCCG CCGCCACAGC CCCTGCCCAG CCCCGCGTAC 
CCCGCGCCGC GGCCGGCTCC CGGGCCCGCA CCTTTCGTGC CCCGCGAGCG CGCCTCAGTG 
GACCGCTGGC GCCGGACCAA GGGCGCGGGG CCGCCGGGGG GCGCGGGCCT GGCCGACGGC 
TTCCACCGCT ACTACGGCCC CATCGAGCCG CAGGGCCTAG GCCTCGGCCT GGGCGAAGCG 
CGCGCGGCAC CGCGGGGCGC AGCCGGGCGC CCGCTGTCCC CGCCGGCCGC TCAGCCCCCG 
CAGAAGCCGC CGCCCTCCTA TTTCGCCATC GTACGCGACA AGGAGCCAGC CGAGCCCCCC 
GCCGGCGCCT TCCCCGGCTT CCCGTCGCCG CCCGCGCCCC CCGCCGCCGC GGCCACCGCC 
GTCGGGCCGC CACTCTGCCG CTTGGCCTTC GAGGACGAGA GCCCGCCGGC GCCCGCGCGG 
TGGCCGCGCT CGGACCCCGA GAGCCAACCC CTGCTGGGGC CAGGCGCGGG CGGCGCGGGG 
GGCACGGGGG GCGCAGGCGG AGGAGCCCCG GCCGCTCCGC CCCCGTGCCG CGCCGCGCCG 
CCCCCGTGCC CTTACCTCGA TCTCGAGCCG TCGCCGTCGG ACTCGGAGGA CTCGGAGAGC 
CTGGGCGGCG CGTCGCTGGG CGGCCTGGAG CCCTGGTGGT TCGCCGACTT CCCTTACCCG 
TATGCCGAGC GCCTCGGGCC GCCGCCCGGC CGCTACTGGT CGGTCGACAA GCTCGGGGGC 
TGGCGCGCCG GGAGCTGGGA CTACCTGCCC CCGCGCAGCG GTCCGGCCGC CTGGCACTGT 
CGGCACTGCG CCAGCCTGGA GCTGCTGCCG CCGCCGCGCC ATCTCAGCTG CTCGCACGAT 
GGCCTGGACG GCGGCTGGTG GGCGCCACCG CCTCCACCCT GGGCCGCCGG GCCCCTGCCC 
CGACGCCGGG CCCGCTGCGG GTGCCCGCGG TCGCACCCGC ACCGCCCGCG GGCCTCGCAC 
CGCACGCCCG CCGCCGCCGC GCCCCACCAC CACAGGCACC GGCGCGCCGC TGGGGGCTGG 
GACCTCCCGC CGCCCGCGCC CACCTCGCGC TCGCTCGAGG ACCTCAGCTC GTGCCCTCGC 
GCCGCCCCTG CGCGCAGGCT TACCGGGCCC TCCCGCCACG CTCGCAGGTG TCCGCACGCC 
GCGCACTGGG GGCCGCCGCT GCCCACAGCT TCCCACCGGA GACACCGGGG CGGGGACCTG 
GGCACCCGCA GGGGCTCGGC GCACTTCTCT AGCCTCGAGT CCGAGGTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525174.1
CDS	257..4267
Translation	MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFSSLESEV

Target ORF information:

RefSeq Version	XM_011526872.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate ionotropic receptor NMDA type subunit 2D (GRIN2D), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526872.1

ORF Insert Sequence:

ATGCGCGGCG CCGGTGGCCC CCGCGGCCCT CGGGGCCCCG CTAAGATGCT GCTGCTGCTG 
GCGCTGGCCT GCGCCAGCCC GTTCCCGGAG GAGGCGCCGG GGCCGGGCGG GGCCGGTGGG 
CCCGGCGGCG GCCTCGGCGG GGCGCGGCCG CTCAACGTGG CGCTCGTGTT CTCGGGGCCC 
GCGTACGCGG CCGAGGCGGC ACGCCTGGGC CCGGCCGTGG CGGCGGCGGT GCGCAGCCCG 
GGCCTAGACG TGCGGCCCGT GGCGCTGGTG CTCAACGGCT CGGACCCGCG CAGCCTCGTG 
CTGCAGCTCT GCGACCTGCT GTCGGGGTTG CGCGTGCACG GCGTGGTCTT CGAAGACGAC 
TCGCGCGCGC CCGCCGTCGC GCCCATCCTC GACTTCCTGT CGGCGCAGAC CTCGCTGCCC 
ATCGTGGCCG TGCACGGCGG CGCCGCGCTC GTGCTCACGC CCAAGGAGAA GGGCTCCACC 
TTCCTGCAGC TGGGCTCTTC CACCGAGCAA CAGCTTCAGG TCATCTTTGA GGTGCTGGAG 
GAGTATGACT GGACGTCCTT TGTAGCCGTG ACCACTCGTG CCCCTGGCCA CCGGGCCTTC 
CTGTCCTACA TTGAGGTGCT GACTGACGGT AGTCTGGTGG GCTGGGAGCA CCGCGGAGCG 
CTGACGCTGG ACCCTGGGGC GGGCGAGGCC GTGCTCAGTG CCCAGCTCCG CAGTGTCAGC 
GCGCAGATCC GCCTGCTCTT CTGCGCCCGA GAGGAGGCCG AGCCCGTGTT CCGCGCAGCT 
GAGGAGGCTG GCCTCACTGG ATCTGGCTAC GTCTGGTTCA TGGTGGGGCC CCAGCTGGCT 
GGAGGCGGGG GCTCTGGGGC CCCTGGTGAG CCCCCTCTTC TGCCAGGAGG CGCCCCCCTG 
CCTGCCGGGC TGTTTGCAGT GCGCTCGGCT GGCTGGCGGG ATGACCTGGC TCGGCGAGTG 
GCAGCTGGCG TGGCCGTAGT GGCCAGAGGT GCCCAGGCCC TGCTGCGTGA TTATGGTTTC 
CTTCCTGAGC TCGGCCACGA CTGTCGCGCC CAGAACCGCA CCCACCGCGG CGAGAGTCTG 
CATAGGTACT TCATGAACAT CACGTGGGAT AACCGGGATT ACTCCTTCAA TGAGGACGGC 
TTCCTAGTGA ACCCCTCCCT GGTGGTCATC TCCCTCACCA GAGACAGGAC GTGGGAGGTG 
GTGGGCAGCT GGGAGCAGCA GACGCTCCGC CTCAAGTACC CGCTGTGGTC CCGCTATGGT 
CGCTTCCTGC AGCCAGTGGA CGACACGCAG CACCTCACGG TGGCCACGCT GGAGGAAAGG 
CCGTTTGTCA TCGTGGAGCC TGCAGACCCT ATCAGCGGCA CCTGCATCCG AGACTCCGTC 
CCCTGCCGGA GCCAGCTCAA CCGAACCCAC AGCCCTCCAC CGGATGCCCC CCGCCCGGAA 
AAGCGCTGCT GCAAGGGTTT CTGCATCGAC ATTCTGAAGC GGCTGGCGCA TACCATCGGC 
TTCAGCTACG ACCTCTACCT GGTCACCAAT GGCAAGCACG GAAAGAAGAT CGATGGCGTC 
TGGAACGGCA TGATCGGGGA GGTGTTCTAC CAGCGCGCAG ACATGGCCAT CGGCTCCCTC 
ACCATCAACG AGGAGCGCTC CGAGATCGTG GACTTCTCCG TCCCCTTCGT GGAGACCGGC 
ATCAGCGTCA TGGTGGCGCG CAGCAATGGC ACGGTGTCCC CCTCGGCCTT CCTCGAGCCC 
TACAGCCCCG CCGTGTGGGT GATGATGTTC GTCATGTGCC TCACTGTGGT CGCCGTCACT 
GTTTTCATCT TCGAGTACCT CAGTCCTGTT GGTTACAACC GCAGCCTGGC CACGGGCAAG 
CGCCCTGGCG GTTCAACCTT CACCATTGGG AAATCCATCT GGCTGCTCTG GGCCCTGGTG 
TTCAATAATT CGGTGCCCGT GGAGAACCCC CGGGGAACCA CCAGCAAAAT CATGGTGCTG 
GTGTGGGCCT TCTTCGCCGT CATCTTCCTC GCCAGCTACA CAGCCAACCT GGCCGCCTTC 
ATGATCCAGG AGGAGTACGT GGATACTGTG TCTGGGCTCA GTGACCGCAA GTTCCAGAGG 
CCCCAGGAGC AGTACCCGCC CCTGAAGTTT GGGACCGTGC CCAACGGCTC CACGGAGAAG 
AACATCCGCA GCAACTATCC CGACATGCAC AGCTACATGG TGCGCTACAA CCAGCCCCGC 
GTAGAGGAAG CGCTCACTCA GCTCAAGGCA GGGAAGCTGG ACGCCTTCAT CTACGATGCT 
GCAGTGCTCA ATTACATGGC CCGCAAGGAC GAGGGCTGCA AGCTTGTCAC CATCGGCTCC 
GGCAAGGTCT TCGCCACGAC AGGCTATGGC ATCGCCCTGC ACAAGGGCTC CCGCTGGAAG 
CGGCCCATCG ACCTGGCGTT GCTGCAGTTC CTGGGGGATG ATGAGATCGA GATGCTGGAG 
CGGCTGTGGC TCTCTGGGAT CTGCCACAAT GACAAAATCG AGGTGATGAG CAGCAAGCTG 
GACATCGACA ACATGGCGGG CGTCTTCTAC ATGCTCCTGG TGGCCATGGG CCTGTCCCTG 
CTGGTCTTCG CCTGGGAGCA CCTGGTGTAC TGGCGCCTGC GGCACTGCCT GGGGCCCACC 
CACCGCATGG ACTTCCTGCT GGCCTTCTCC AGGGGCATGT ACAGCTGCTG CAGCGCTGAG 
GCCGCCCCAC CGCCCGCCAA GCCCCCGCCG CCGCCACAGC CCCTGCCCAG CCCCGCGTAC 
CCCGCGCCGC GGCCGGCTCC CGGGCCCGCA CCTTTCGTGC CCCGCGAGCG CGCCTCAGTG 
GACCGCTGGC GCCGGACCAA GGGCGCGGGG CCGCCGGGGG GCGCGGGCCT GGCCGACGGC 
TTCCACCGCT ACTACGGCCC CATCGAGCCG CAGGGCCTAG GCCTCGGCCT GGGCGAAGCG 
CGCGCGGCAC CGCGGGGCGC AGCCGGGCGC CCGCTGTCCC CGCCGGCCGC TCAGCCCCCG 
CAGAAGCCGC CGCCCTCCTA TTTCGCCATC GTACGCGACA AGGAGCCAGC CGAGCCCCCC 
GCCGGCGCCT TCCCCGGCTT CCCGTCGCCG CCCGCGCCCC CCGCCGCCGC GGCCACCGCC 
GTCGGGCCGC CACTCTGCCG CTTGGCCTTC GAGGACGAGA GCCCGCCGGC GCCCGCGCGG 
TGGCCGCGCT CGGACCCCGA GAGCCAACCC CTGCTGGGGC CAGGCGCGGG CGGCGCGGGG 
GGCACGGGGG GCGCAGGCGG AGGAGCCCCG GCCGCTCCGC CCCCGTGCCG CGCCGCGCCG 
CCCCCGTGCC CTTACCTCGA TCTCGAGCCG TCGCCGTCGG ACTCGGAGGA CTCGGAGAGC 
CTGGGCGGCG CGTCGCTGGG CGGCCTGGAG CCCTGGTGGT TCGCCGACTT CCCTTACCCG 
TATGCCGAGC GCCTCGGGCC GCCGCCCGGC CGCTACTGGT CGGTCGACAA GCTCGGGGGC 
TGGCGCGCCG GGAGCTGGGA CTACCTGCCC CCGCGCAGCG GTCCGGCCGC CTGGCACTGT 
CGGCACTGCG CCAGCCTGGA GCTGCTGCCG CCGCCGCGCC ATCTCAGCTG CTCGCACGAT 
GGCCTGGACG GCGGCTGGTG GGCGCCACCG CCTCCACCCT GGGCCGCCGG GCCCCTGCCC 
CGACGCCGGG CCCGCTGCGG GTGCCCGCGG TCGCACCCGC ACCGCCCGCG GGCCTCGCAC 
CGCACGCCCG CCGCCGCCGC GCCCCACCAC CACAGGCACC GGCGCGCCGC TGGGGGCTGG 
GACCTCCCGC CGCCCGCGCC CACCTCGCGC TCGCTCGAGG ACCTCAGCTC GTGCCCTCGC 
GCCGCCCCTG CGCGCAGGCT TACCGGGCCC TCCCGCCACG CTCGCAGGTG TCCGCACGCC 
GCGCACTGGG GGCCGCCGCT GCCCACAGCT TCCCACCGGA GACACCGGGG CGGGGACCTG 
GGCACCCGCA GGGGCTCGGC GCACTTCTCT AGCCTCGAGT CCGAGGTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The excitotoxity of NMDA receptor NR2D subtype mediates human fetal lung fibroblasts proliferation and collagen production.
Toxicology in vitro : an international journal published in association with BIBRA4647-57(2018 Feb)
Wang M,Luo Z,Yue Y,Wang Y,Wu S,Cao C,Liao Z,Yu X,Yue S

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.
Translational psychiatry8(1)12(2018 Jan)
Yu Y,Lin Y,Takasaki Y,Wang C,Kimura H,Xing J,Ishizuka K,Toyama M,Kushima I,Mori D,Arioka Y,Uno Y,Shiino T,Nakamura Y,Okada T,Morikawa M,Ikeda M,Iwata N,Okahisa Y,Takaki M,Sakamoto S,Someya T,Egawa J,Usami M,Kodaira M,Yoshimi A,Oya-Ito T,Aleksic B,Ohno K,Ozaki N

AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women.
Journal of neuroimmunology30551-58(2017 Apr)
Bhandage AK,Jin Z,Hellgren C,Korol SV,Nowak K,Williamsson L,Sundstr?m-Poromaa I,Birnir B

GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.
American journal of human genetics99(4)802-816(2016 Oct)
Li D,Yuan H,Ortiz-Gonzalez XR,Marsh ED,Tian L,McCormick EM,Kosobucki GJ,Chen W,Schulien AJ,Chiavacci R,Tankovic A,Naase C,Brueckner F,von St?lpnagel-Steinbeis C,Hu C,Kusumoto H,Hedrich UB,Elsen G,H?rtnagel K,Aizenman E,Lemke JR,Hakonarson H,Traynelis SF,Falk MJ

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GRIN2D cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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