MRPL13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPL13
Entrez Gene ID	28998
Full Name	mitochondrial ribosomal protein L13
Synonyms	L13,L13A,L13mt,RPL13,RPML13
General protein information	Preferred Names mitochondrial ribosomal protein L13 Names 39S ribosomal protein L13, mitochondrial MRP-L13 mitochondrial large ribosomal subunit protein uL13m
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.12
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	610200

mRNA and Protein(s)

mRNA	Protein	Name
NM_014078.5	NP_054797.2	39S ribosomal protein L13, mitochondrial
NM_014078.6	NP_054797.2	39S ribosomal protein L13, mitochondrial

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Mrpl13	NP_001006986.1
Pan troglodytes (chimpanzee)	MRPL13	XP_003951387.1
Danio rerio (zebrafish)	mrpl13	NP_001018370.1
Oryza sativa (rice)	Os01g0749200	NP_001044246.1
Homo sapiens (human)	MRPL13	NP_054797.2
	MRPL13	XP_001097952.1
Canis lupus familiaris (dog)	MRPL13	XP_005627956.1
Bos taurus (cattle)	MRPL13	NP_001029977.1
Mus musculus (house mouse)	Mrpl13	NP_081035.1
Gallus gallus (chicken)	MRPL13	NP_001264400.1
Caenorhabditis elegans (roundworm)	mrpl-13	NP_492067.1
Drosophila melanogaster (fruit fly)	mRpL13	NP_523598.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009908	XP_319028.4
Saccharomyces cerevisiae (baker's yeast)	MRPL23	NP_014793.1
Eremothecium gossypii	AGOS_AFR403W	NP_985950.1
Arabidopsis thaliana (thale cress)	emb1473	NP_177984.1
Xenopus tropicalis (tropical clawed frog)	mrpl13	NP_001016796.2
Kluyveromyces lactis	KLLA0D02508g	XP_453180.1
Schizosaccharomyces pombe (fission yeast)	mrpl23	NP_596753.1
Magnaporthe oryzae (rice blast fungus)	MGG_05282	XP_003712842.1
Neurospora crassa	NCU07852	XP_963113.1

Gene Ontology
Bibliography

Related articles in PubMed

Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness.
Lee YK, Lim JJ, Jeoun UW, Min S, Lee EB, Kwon SM, Lee C, Yoon G
The Journal of biological chemistry292(49)20208-20217(2017 12)

Structures of the human mitochondrial ribosome in native states of assembly.
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nature structural & molecular biology24(10)866-869(2017 Oct)

Structure of the large ribosomal subunit from human mitochondria.
Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)346(6210)718-722(2014 Nov)

Epidemiological and genome-wide association study of gastritis or gastric ulcer in korean populations.
Oh S, Oh S
Genomics & informatics12(3)127-33(2014 Sep)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the combination of elevated glycolysis and deficient MRPL13 activity was closely linked to CLN1-mediated tumor activity in human hepatoma cells
Title: Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

DAPK-ZIPK-L13a axis forms a unique regulatory module that first represses, then repermits inflammatory gene expression.
Title: DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression.

The following MRPL13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPL13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09378	NM_014078.6 Latest version!	Homo sapiens mitochondrial ribosomal protein L13 (MRPL13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09378	NM_014078.5	Homo sapiens mitochondrial ribosomal protein L13 (MRPL13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPL13 ( NM_014078.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_054797.2 Homo sapiens mitochondrial ribosomal protein L13 (MRPL13), mRNA.

Price & Availability↑

CloneID	OHu09378
Clone ID Related Accession (Same CDS sequence)	NM_014078.5 , NM_014078.6
Accession Version	NM_014078.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	39S ribosomal protein L13, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF243677.1, BC021744.2 and CN362173.1. On Nov 19, 2010 this sequence version replaced NM_014078.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.323260.1, SRR1163657.322773.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCGAGTT TCTCTAGGGC GCCCCAGCAA TGGGCCACTT TTGCTAGAAT ATGGTATCTC 
TTAGATGGGA AAATGCAGCC ACCTGGCAAA CTTGCTGCTA TGGCATCTAT AAGACTTCAG 
GGATTACATA AACCTGTGTA CCATGCACTG AGTGACTGTG GGGATCATGT TGTTATAATG 
AACACAAGAC ACATTGCATT TTCTGGAAAC AAATGGGAAC AAAAAGTATA CTCTTCGCAT 
ACTGGCTACC CAGGTGGATT TAGACAAGTA ACAGCTGCTC AGCTTCACCT GAGGGATCCA 
GTGGCAATTG TAAAACTAGC TATTTATGGC ATGCTGCCAA AAAACCTTCA CAGAAGAACA 
ATGATGGAAA GGTTGCATCT TTTTCCAGAT GAGTATATTC CAGAAGATAT TCTTAAGAAT 
TTAGTAGAGG AGCTTCCTCA ACCACGAAAA ATACCTAAAC GTCTAGATGA GTACACACAA 
GAAGAAATAG ACGCCTTCCC AAGATTGTGG ACTCCACCTG AAGATTATCG GCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054797.2
CDS	314..850
Translation	MSSFSRAPQQWATFARIWYLLDGKMQPPGKLAAMASIRLQGLHKPVYHALSDCGDHVVIMNTRHIAFSGNKWEQKVYSSHTGYPGGFRQVTAAQLHLRDPVAIVKLAIYGMLPKNLHRRTMMERLHLFPDEYIPEDILKNLVEELPQPRKIPKRLDEYTQEEIDAFPRLWTPPEDYRL

Target ORF information:

RefSeq Version	NM_014078.5
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L13 (MRPL13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014078.5

ORF Insert Sequence:

ATGTCGAGTT TCTCTAGGGC GCCCCAGCAA TGGGCCACTT TTGCTAGAAT ATGGTATCTC 
TTAGATGGGA AAATGCAGCC ACCTGGCAAA CTTGCTGCTA TGGCATCTAT AAGACTTCAG 
GGATTACATA AACCTGTGTA CCATGCACTG AGTGACTGTG GGGATCATGT TGTTATAATG 
AACACAAGAC ACATTGCATT TTCTGGAAAC AAATGGGAAC AAAAAGTATA CTCTTCGCAT 
ACTGGCTACC CAGGTGGATT TAGACAAGTA ACAGCTGCTC AGCTTCACCT GAGGGATCCA 
GTGGCAATTG TAAAACTAGC TATTTATGGC ATGCTGCCAA AAAACCTTCA CAGAAGAACA 
ATGATGGAAA GGTTGCATCT TTTTCCAGAT GAGTATATTC CAGAAGATAT TCTTAAGAAT 
TTAGTAGAGG AGCTTCCTCA ACCACGAAAA ATACCTAAAC GTCTAGATGA GTACACACAA 
GAAGAAATAG ACGCCTTCCC AAGATTGTGG ACTCCACCTG AAGATTATCG GCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL13 ( NM_014078.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_054797.2 Homo sapiens mitochondrial ribosomal protein L13 (MRPL13), mRNA.

Price & Availability↑

CloneID	OHu09378
Clone ID Related Accession (Same CDS sequence)	NM_014078.5 , NM_014078.6
Accession Version	NM_014078.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	39S ribosomal protein L13, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC021744.2, CN362173.1 and AC107877.4. On May 17, 2019 this sequence version replaced NM_014078.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.222976.1, SRR1803613.42532.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000306185.8/ ENSP00000306548.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCGAGTT TCTCTAGGGC GCCCCAGCAA TGGGCCACTT TTGCTAGAAT ATGGTATCTC 
TTAGATGGGA AAATGCAGCC ACCTGGCAAA CTTGCTGCTA TGGCATCTAT AAGACTTCAG 
GGATTACATA AACCTGTGTA CCATGCACTG AGTGACTGTG GGGATCATGT TGTTATAATG 
AACACAAGAC ACATTGCATT TTCTGGAAAC AAATGGGAAC AAAAAGTATA CTCTTCGCAT 
ACTGGCTACC CAGGTGGATT TAGACAAGTA ACAGCTGCTC AGCTTCACCT GAGGGATCCA 
GTGGCAATTG TAAAACTAGC TATTTATGGC ATGCTGCCAA AAAACCTTCA CAGAAGAACA 
ATGATGGAAA GGTTGCATCT TTTTCCAGAT GAGTATATTC CAGAAGATAT TCTTAAGAAT 
TTAGTAGAGG AGCTTCCTCA ACCACGAAAA ATACCTAAAC GTCTAGATGA GTACACACAA 
GAAGAAATAG ACGCCTTCCC AAGATTGTGG ACTCCACCTG AAGATTATCG GCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054797.2
CDS	57..593
Translation	MSSFSRAPQQWATFARIWYLLDGKMQPPGKLAAMASIRLQGLHKPVYHALSDCGDHVVIMNTRHIAFSGNKWEQKVYSSHTGYPGGFRQVTAAQLHLRDPVAIVKLAIYGMLPKNLHRRTMMERLHLFPDEYIPEDILKNLVEELPQPRKIPKRLDEYTQEEIDAFPRLWTPPEDYRL

Target ORF information:

RefSeq Version	NM_014078.6
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L13 (MRPL13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014078.6

ORF Insert Sequence:

ATGTCGAGTT TCTCTAGGGC GCCCCAGCAA TGGGCCACTT TTGCTAGAAT ATGGTATCTC 
TTAGATGGGA AAATGCAGCC ACCTGGCAAA CTTGCTGCTA TGGCATCTAT AAGACTTCAG 
GGATTACATA AACCTGTGTA CCATGCACTG AGTGACTGTG GGGATCATGT TGTTATAATG 
AACACAAGAC ACATTGCATT TTCTGGAAAC AAATGGGAAC AAAAAGTATA CTCTTCGCAT 
ACTGGCTACC CAGGTGGATT TAGACAAGTA ACAGCTGCTC AGCTTCACCT GAGGGATCCA 
GTGGCAATTG TAAAACTAGC TATTTATGGC ATGCTGCCAA AAAACCTTCA CAGAAGAACA 
ATGATGGAAA GGTTGCATCT TTTTCCAGAT GAGTATATTC CAGAAGATAT TCTTAAGAAT 
TTAGTAGAGG AGCTTCCTCA ACCACGAAAA ATACCTAAAC GTCTAGATGA GTACACACAA 
GAAGAAATAG ACGCCTTCCC AAGATTGTGG ACTCCACCTG AAGATTATCG GCTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness.
The Journal of biological chemistry292(49)20208-20217(2017 12)
Lee YK,Lim JJ,Jeoun UW,Min S,Lee EB,Kwon SM,Lee C,Yoon G

Structures of the human mitochondrial ribosome in native states of assembly.
Nature structural & molecular biology24(10)866-869(2017 Oct)
Brown A,Rathore S,Kimanius D,Aibara S,Bai XC,Rorbach J,Amunts A,Ramakrishnan V

Structure of the large ribosomal subunit from human mitochondria.
Science (New York, N.Y.)346(6210)718-722(2014 Nov)
Brown A,Amunts A,Bai XC,Sugimoto Y,Edwards PC,Murshudov G,Scheres SHW,Ramakrishnan V

Epidemiological and genome-wide association study of gastritis or gastric ulcer in korean populations.
Genomics & informatics12(3)127-33(2014 Sep)
Oh S,Oh S

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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MRPL13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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