RGCC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RGCC
Entrez Gene ID	28984
Full Name	regulator of cell cycle
Synonyms	C13orf15,RGC-32,RGC32,bA157L14.2
General protein information	Preferred Names regulator of cell cycle Names regulator of cell cycle RGCC response gene to complement 32 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q14.11
Summary	This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008].
Disorder MIM:	610077

mRNA and Protein(s)

mRNA	Protein	Name
NM_014059.2	NP_054778.2	regulator of cell cycle RGCC
NM_014059.3	NP_054778.2	regulator of cell cycle RGCC

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RGCC	NP_001095746.1
Xenopus tropicalis (tropical clawed frog)	rgcc	NP_001096268.1
Gallus gallus (chicken)	C1H13ORF15	XP_417029.1
Danio rerio (zebrafish)	rgcc	NP_001002190.1
Mus musculus (house mouse)	Rgcc	NP_079703.2
Homo sapiens (human)	RGCC	NP_054778.2
Pan troglodytes (chimpanzee)	RGCC	XP_001170481.2
	C13orf15	XP_001091614.1
Rattus norvegicus (Norway rat)	LOC683573	XP_003750007.1
Rattus norvegicus (Norway rat)	Rgcc	NP_446460.1

Gene Ontology
Bibliography

Related articles in PubMed

RGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC.
Wang XY, Li SN, Zhu HF, Hu ZY, Zhong Y, Gu CS, Chen SY, Liu TF, Li ZG
Scientific reports746078(2017 May)

Regulator of Cell Cycle (RGCC) Expression During the Progression of Alzheimer's Disease.
Counts SE, Mufson EJ
Cell transplantation26(4)693-702(2017 Apr)

Response Gene to Complement-32 Promotes the Imbalance of Treg/Th17 in Patients with Dilated Cardiomyopathy.
Li B, Zhou W, Tang X, Wang W, Pan J, Tan M
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology43(4)1515-1525(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RGCC may be a candidate cell cycle target for neuroprotection during the onset of Alzheimer's disease.
Title: Regulator of Cell Cycle (RGCC) Expression During the Progression of Alzheimer's Disease.

This study demonstrated the up-regulation of RGC-32 contributed to the imbalance of Treg/Th17 cells in patients with Dilated Cardiomyopathy. [RGC-32]
Title: Response Gene to Complement-32 Promotes the Imbalance of Treg/Th17 in Patients with Dilated Cardiomyopathy.

RGC-32 mediates human aortic endothelial cell migration through the regulation of RhoA and ROCK1 expression.
Title: RGC-32 is expressed in the human atherosclerotic arterial wall: Role in C5b-9-induced cell proliferation and migration.

RGC-32 expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4.
Title: Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4.

Data suggest that expression of RGC32 is down-regulated in placental trophoblasts in women with pre-eclampsia as compared to women with normal term pregnancies; silencing RGC32 expression by RNA interference inhibits trophoblast migration/invasion.
Title: Expression of RGC32 in human normal and preeclamptic placentas and its role in trophoblast cell invasion and migration.

The following RGCC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RGCC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13900	NM_014059.3 Latest version!	Homo sapiens regulator of cell cycle (RGCC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu13900	NM_014059.2	Homo sapiens regulator of cell cycle (RGCC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RGCC ( NM_014059.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_054778.2 Homo sapiens regulator of cell cycle (RGCC), mRNA.

Price & Availability↑

CloneID	OHu13900
Clone ID Related Accession (Same CDS sequence)	NM_014059.2 , NM_014059.3
Accession Version	NM_014059.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	regulator of cell cycle RGCC
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB451897.1, BC066334.1 and BU679672.1. On or before Mar 16, 2007 this sequence version replaced XM_001132553.1, NM_014059.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.425620.1, ERR279873.1070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCGC CCGCGGCGCA GGGCAGCCCC GCGGCCGCCG CGGCCGCAGC CCCGGCCCTG 
GACTCGGCGG CCGCGGAGGA CCTGTCGGAC GCGCTGTGCG AGTTTGACGC GGTGCTGGCC 
GACTTCGCGT CGCCCTTCCA CGAGCGCCAC TTCCACTACG AGGAGCACCT GGAGCGCATG 
AAGCGGCGCA GCAGCGCCAG TGTCAGCGAC AGCAGCGGCT TCAGCGACTC GGAGAGTGCA 
GATTCACTTT ATAGGAACAG CTTCAGCTTC AGTGATGAAA AACTGAATTC TCCAACAGAC 
TCTACCCCAG CTCTTCTCTC TGCCACTGTC ACTCCTCAGA AAGCTAAATT AGGAGACACA 
AAAGAGCTAG AAGCCTTCAT TGCTGATCTT GACAAAACTT TAGCAAGTAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054778.2
CDS	303..716
Translation	MKPPAAQGSPAAAAAAAPALDSAAAEDLSDALCEFDAVLADFASPFHERHFHYEEHLERMKRRSSASVSDSSGFSDSESADSLYRNSFSFSDEKLNSPTDSTPALLSATVTPQKAKLGDTKELEAFIADLDKTLASM

Target ORF information:

RefSeq Version	NM_014059.2
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of cell cycle (RGCC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014059.2

ORF Insert Sequence:

ATGAAGCCGC CCGCGGCGCA GGGCAGCCCC GCGGCCGCCG CGGCCGCAGC CCCGGCCCTG 
GACTCGGCGG CCGCGGAGGA CCTGTCGGAC GCGCTGTGCG AGTTTGACGC GGTGCTGGCC 
GACTTCGCGT CGCCCTTCCA CGAGCGCCAC TTCCACTACG AGGAGCACCT GGAGCGCATG 
AAGCGGCGCA GCAGCGCCAG TGTCAGCGAC AGCAGCGGCT TCAGCGACTC GGAGAGTGCA 
GATTCACTTT ATAGGAACAG CTTCAGCTTC AGTGATGAAA AACTGAATTC TCCAACAGAC 
TCTACCCCAG CTCTTCTCTC TGCCACTGTC ACTCCTCAGA AAGCTAAATT AGGAGACACA 
AAAGAGCTAG AAGCCTTCAT TGCTGATCTT GACAAAACTT TAGCAAGTAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGCC ( NM_014059.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_054778.2 Homo sapiens regulator of cell cycle (RGCC), mRNA.

Price & Availability↑

CloneID	OHu13900
Clone ID Related Accession (Same CDS sequence)	NM_014059.2 , NM_014059.3
Accession Version	NM_014059.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-20
Organism	Homo sapiens(human)
Product	regulator of cell cycle RGCC
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB451897.1 and BC066334.1. On Nov 22, 2018 this sequence version replaced NM_014059.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066334.1, ERR279873.1070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000379359.4/ ENSP00000368664.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCCGC CCGCGGCGCA GGGCAGCCCC GCGGCCGCCG CGGCCGCAGC CCCGGCCCTG 
GACTCGGCGG CCGCGGAGGA CCTGTCGGAC GCGCTGTGCG AGTTTGACGC GGTGCTGGCC 
GACTTCGCGT CGCCCTTCCA CGAGCGCCAC TTCCACTACG AGGAGCACCT GGAGCGCATG 
AAGCGGCGCA GCAGCGCCAG TGTCAGCGAC AGCAGCGGCT TCAGCGACTC GGAGAGTGCA 
GATTCACTTT ATAGGAACAG CTTCAGCTTC AGTGATGAAA AACTGAATTC TCCAACAGAC 
TCTACCCCAG CTCTTCTCTC TGCCACTGTC ACTCCTCAGA AAGCTAAATT AGGAGACACA 
AAAGAGCTAG AAGCCTTCAT TGCTGATCTT GACAAAACTT TAGCAAGTAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054778.2
CDS	159..572
Translation	MKPPAAQGSPAAAAAAAPALDSAAAEDLSDALCEFDAVLADFASPFHERHFHYEEHLERMKRRSSASVSDSSGFSDSESADSLYRNSFSFSDEKLNSPTDSTPALLSATVTPQKAKLGDTKELEAFIADLDKTLASM

Target ORF information:

RefSeq Version	NM_014059.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of cell cycle (RGCC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014059.3

ORF Insert Sequence:

ATGAAGCCGC CCGCGGCGCA GGGCAGCCCC GCGGCCGCCG CGGCCGCAGC CCCGGCCCTG 
GACTCGGCGG CCGCGGAGGA CCTGTCGGAC GCGCTGTGCG AGTTTGACGC GGTGCTGGCC 
GACTTCGCGT CGCCCTTCCA CGAGCGCCAC TTCCACTACG AGGAGCACCT GGAGCGCATG 
AAGCGGCGCA GCAGCGCCAG TGTCAGCGAC AGCAGCGGCT TCAGCGACTC GGAGAGTGCA 
GATTCACTTT ATAGGAACAG CTTCAGCTTC AGTGATGAAA AACTGAATTC TCCAACAGAC 
TCTACCCCAG CTCTTCTCTC TGCCACTGTC ACTCCTCAGA AAGCTAAATT AGGAGACACA 
AAAGAGCTAG AAGCCTTCAT TGCTGATCTT GACAAAACTT TAGCAAGTAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC.
Scientific reports746078(2017 May)
Wang XY,Li SN,Zhu HF,Hu ZY,Zhong Y,Gu CS,Chen SY,Liu TF,Li ZG

Regulator of Cell Cycle (RGCC) Expression During the Progression of Alzheimer's Disease.
Cell transplantation26(4)693-702(2017 Apr)
Counts SE,Mufson EJ

Response Gene to Complement-32 Promotes the Imbalance of Treg/Th17 in Patients with Dilated Cardiomyopathy.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology43(4)1515-1525(2017)
Li B,Zhou W,Tang X,Wang W,Pan J,Tan M

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RGCC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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