GRN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GRN
Entrez Gene ID	2896
Full Name	granulin precursor
Synonyms	CLN11,GEP,GP88,PCDGF,PEPI,PGRN
General protein information	Preferred Names granulin precursor Names granulins PC cell-derived growth factor acrogranin granulin-epithelin proepithelin progranulin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.31
Summary	Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
Disorder MIM:	138945
Disorder Html:	Frontotemporal lobar degeneration with ubiquitin-positive inclusions, 607485 (3); Aphasia, primary progressive, 607485 (3); Ceroid lipofuscinosis, neuronal, 11, 614706 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005257253.1	XP_005257310.1	progranulin isoform X1
XM_024450730.1	XP_024306498.1	progranulin isoform X1
NM_002087.3	NP_002078.1	progranulin precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GRN	XP_511549.2
Danio rerio (zebrafish)	grna	XP_005164021.1
Xenopus tropicalis (tropical clawed frog)	grn	NP_001072169.1
	LOC714851	XP_002808178.1
Mus musculus (house mouse)	Grn	NP_032201.2
Homo sapiens (human)	GRN	NP_002078.1
Bos taurus (cattle)	GRN	NP_001070482.1
Rattus norvegicus (Norway rat)	Grn	NP_058809.2

Gene Ontology
Bibliography

Related articles in PubMed

Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression.
Capell A, Fellerer K, Haass C
The Journal of biological chemistry289(37)25879-89(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study demonstrate that PGRN interacts with the lysosomal protease CTSD and maintains its proper activity in vivo. Therefore, by regulating CTSD activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 aggregation observed in frontotemporal lobar degeneration with GRN mutations.
Title: Regulation of cathepsin D activity by the FTLD protein progranulin.

Missense mutation in GRN gene affecting RNA splicing and plasma progranulin level in a family affected by frontotemporal lobar degeneration.
Title: Missense mutation in GRN gene affecting RNA splicing and plasma progranulin level in a family affected by frontotemporal lobar degeneration.

This Progress article reviews recent advances in progranulin biology emphasizing its roles in lysosomal function and brain innate immunity, and outlines future avenues of investigation that may lead to new therapeutic approaches for neurodegeneration--{REVIEW}
Title: Progranulin, lysosomal regulation and neurodegenerative disease.

GRN gene deletion is genetic etiology of familial frontotemporal dementia.
Title: GRN deletion in familial frontotemporal dementia showing association with clinical variability in 3 familial cases.

The GRN risk SNP (rs5848) was associated with variation in detected levels of CSF proteins previously implicated in CNS inflammation. The same GRN risk allele was also associated with increased CSF tau which may indicate directly related neurodegenerative changes.
Title: CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.

The following GRN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GRN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25975	NM_002087.3 Latest version!	Homo sapiens granulin precursor (GRN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu25975	XM_005257253.1 Latest version!	Homo sapiens granulin precursor (GRN), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu25975	XM_024450730.1 Latest version!	Homo sapiens granulin precursor (GRN), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GRN ( NM_002087.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002078.1 Homo sapiens granulin precursor (GRN), mRNA.

Price & Availability↑

CloneID	OHu25975
Clone ID Related Accession (Same CDS sequence)	XM_005257253.1 , XM_024450730.1 , NM_002087.3
Accession Version	NM_002087.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	progranulin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC336362.1, BC010577.2 and AY124489.1. On Nov 14, 2014 this sequence version replaced NM_002087.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.128737.1, SRR1803611.9705.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein regulatory uORF :: PMID: 25056957 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGGACCC TGGTGAGCTG GGTGGCCTTA ACAGCAGGGC TGGTGGCTGG AACGCGGTGC 
CCAGATGGTC AGTTCTGCCC TGTGGCCTGC TGCCTGGACC CCGGAGGAGC CAGCTACAGC 
TGCTGCCGTC CCCTTCTGGA CAAATGGCCC ACAACACTGA GCAGGCATCT GGGTGGCCCC 
TGCCAGGTTG ATGCCCACTG CTCTGCCGGC CACTCCTGCA TCTTTACCGT CTCAGGGACT 
TCCAGTTGCT GCCCCTTCCC AGAGGCCGTG GCATGCGGGG ATGGCCATCA CTGCTGCCCA 
CGGGGCTTCC ACTGCAGTGC AGACGGGCGA TCCTGCTTCC AAAGATCAGG TAACAACTCC 
GTGGGTGCCA TCCAGTGCCC TGATAGTCAG TTCGAATGCC CGGACTTCTC CACGTGCTGT 
GTTATGGTCG ATGGCTCCTG GGGGTGCTGC CCCATGCCCC AGGCTTCCTG CTGTGAAGAC 
AGGGTGCACT GCTGTCCGCA CGGTGCCTTC TGCGACCTGG TTCACACCCG CTGCATCACA 
CCCACGGGCA CCCACCCCCT GGCAAAGAAG CTCCCTGCCC AGAGGACTAA CAGGGCAGTG 
GCCTTGTCCA GCTCGGTCAT GTGTCCGGAC GCACGGTCCC GGTGCCCTGA TGGTTCTACC 
TGCTGTGAGC TGCCCAGTGG GAAGTATGGC TGCTGCCCAA TGCCCAACGC CACCTGCTGC 
TCCGATCACC TGCACTGCTG CCCCCAAGAC ACTGTGTGTG ACCTGATCCA GAGTAAGTGC 
CTCTCCAAGG AGAACGCTAC CACGGACCTC CTCACTAAGC TGCCTGCGCA CACAGTGGGG 
GATGTGAAAT GTGACATGGA GGTGAGCTGC CCAGATGGCT ATACCTGCTG CCGTCTACAG 
TCGGGGGCCT GGGGCTGCTG CCCTTTTACC CAGGCTGTGT GCTGTGAGGA CCACATACAC 
TGCTGTCCCG CGGGGTTTAC GTGTGACACG CAGAAGGGTA CCTGTGAACA GGGGCCCCAC 
CAGGTGCCCT GGATGGAGAA GGCCCCAGCT CACCTCAGCC TGCCAGACCC ACAAGCCTTG 
AAGAGAGATG TCCCCTGTGA TAATGTCAGC AGCTGTCCCT CCTCCGATAC CTGCTGCCAA 
CTCACGTCTG GGGAGTGGGG CTGCTGTCCA ATCCCAGAGG CTGTCTGCTG CTCGGACCAC 
CAGCACTGCT GCCCCCAGGG CTACACGTGT GTAGCTGAGG GGCAGTGTCA GCGAGGAAGC 
GAGATCGTGG CTGGACTGGA GAAGATGCCT GCCCGCCGGG CTTCCTTATC CCACCCCAGA 
GACATCGGCT GTGACCAGCA CACCAGCTGC CCGGTGGGGC AGACCTGCTG CCCGAGCCTG 
GGTGGGAGCT GGGCCTGCTG CCAGTTGCCC CATGCTGTGT GCTGCGAGGA TCGCCAGCAC 
TGCTGCCCGG CTGGCTACAC CTGCAACGTG AAGGCTCGAT CCTGCGAGAA GGAAGTGGTC 
TCTGCCCAGC CTGCCACCTT CCTGGCCCGT AGCCCTCACG TGGGTGTGAA GGACGTGGAG 
TGTGGGGAAG GACACTTCTG CCATGATAAC CAGACCTGCT GCCGAGACAA CCGACAGGGC 
TGGGCCTGCT GTCCCTACCG CCAGGGCGTC TGTTGTGCTG ATCGGCGCCA CTGCTGTCCT 
GCTGGCTTCC GCTGCGCAGC CAGGGGTACC AAGTGTTTGC GCAGGGAGGC CCCGCGCTGG 
GACGCCCCTT TGAGGGACCC AGCCTTGAGA CAGCTGCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002078.1
CDS	257..2038
Translation	MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL

Target ORF information:

RefSeq Version	NM_002087.3
Organism	Homo sapiens(human)
Definition	Homo sapiens granulin precursor (GRN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002087.3

ORF Insert Sequence:

ATGTGGACCC TGGTGAGCTG GGTGGCCTTA ACAGCAGGGC TGGTGGCTGG AACGCGGTGC 
CCAGATGGTC AGTTCTGCCC TGTGGCCTGC TGCCTGGACC CCGGAGGAGC CAGCTACAGC 
TGCTGCCGTC CCCTTCTGGA CAAATGGCCC ACAACACTGA GCAGGCATCT GGGTGGCCCC 
TGCCAGGTTG ATGCCCACTG CTCTGCCGGC CACTCCTGCA TCTTTACCGT CTCAGGGACT 
TCCAGTTGCT GCCCCTTCCC AGAGGCCGTG GCATGCGGGG ATGGCCATCA CTGCTGCCCA 
CGGGGCTTCC ACTGCAGTGC AGACGGGCGA TCCTGCTTCC AAAGATCAGG TAACAACTCC 
GTGGGTGCCA TCCAGTGCCC TGATAGTCAG TTCGAATGCC CGGACTTCTC CACGTGCTGT 
GTTATGGTCG ATGGCTCCTG GGGGTGCTGC CCCATGCCCC AGGCTTCCTG CTGTGAAGAC 
AGGGTGCACT GCTGTCCGCA CGGTGCCTTC TGCGACCTGG TTCACACCCG CTGCATCACA 
CCCACGGGCA CCCACCCCCT GGCAAAGAAG CTCCCTGCCC AGAGGACTAA CAGGGCAGTG 
GCCTTGTCCA GCTCGGTCAT GTGTCCGGAC GCACGGTCCC GGTGCCCTGA TGGTTCTACC 
TGCTGTGAGC TGCCCAGTGG GAAGTATGGC TGCTGCCCAA TGCCCAACGC CACCTGCTGC 
TCCGATCACC TGCACTGCTG CCCCCAAGAC ACTGTGTGTG ACCTGATCCA GAGTAAGTGC 
CTCTCCAAGG AGAACGCTAC CACGGACCTC CTCACTAAGC TGCCTGCGCA CACAGTGGGG 
GATGTGAAAT GTGACATGGA GGTGAGCTGC CCAGATGGCT ATACCTGCTG CCGTCTACAG 
TCGGGGGCCT GGGGCTGCTG CCCTTTTACC CAGGCTGTGT GCTGTGAGGA CCACATACAC 
TGCTGTCCCG CGGGGTTTAC GTGTGACACG CAGAAGGGTA CCTGTGAACA GGGGCCCCAC 
CAGGTGCCCT GGATGGAGAA GGCCCCAGCT CACCTCAGCC TGCCAGACCC ACAAGCCTTG 
AAGAGAGATG TCCCCTGTGA TAATGTCAGC AGCTGTCCCT CCTCCGATAC CTGCTGCCAA 
CTCACGTCTG GGGAGTGGGG CTGCTGTCCA ATCCCAGAGG CTGTCTGCTG CTCGGACCAC 
CAGCACTGCT GCCCCCAGGG CTACACGTGT GTAGCTGAGG GGCAGTGTCA GCGAGGAAGC 
GAGATCGTGG CTGGACTGGA GAAGATGCCT GCCCGCCGGG CTTCCTTATC CCACCCCAGA 
GACATCGGCT GTGACCAGCA CACCAGCTGC CCGGTGGGGC AGACCTGCTG CCCGAGCCTG 
GGTGGGAGCT GGGCCTGCTG CCAGTTGCCC CATGCTGTGT GCTGCGAGGA TCGCCAGCAC 
TGCTGCCCGG CTGGCTACAC CTGCAACGTG AAGGCTCGAT CCTGCGAGAA GGAAGTGGTC 
TCTGCCCAGC CTGCCACCTT CCTGGCCCGT AGCCCTCACG TGGGTGTGAA GGACGTGGAG 
TGTGGGGAAG GACACTTCTG CCATGATAAC CAGACCTGCT GCCGAGACAA CCGACAGGGC 
TGGGCCTGCT GTCCCTACCG CCAGGGCGTC TGTTGTGCTG ATCGGCGCCA CTGCTGTCCT 
GCTGGCTTCC GCTGCGCAGC CAGGGGTACC AAGTGTTTGC GCAGGGAGGC CCCGCGCTGG 
GACGCCCCTT TGAGGGACCC AGCCTTGAGA CAGCTGCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRN ( XM_005257253.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005257310.1 Homo sapiens granulin precursor (GRN), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu25975
Clone ID Related Accession (Same CDS sequence)	XM_005257253.1 , XM_024450730.1 , NM_002087.3
Accession Version	XM_005257253.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	progranulin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGACCC TGGTGAGCTG GGTGGCCTTA ACAGCAGGGC TGGTGGCTGG AACGCGGTGC 
CCAGATGGTC AGTTCTGCCC TGTGGCCTGC TGCCTGGACC CCGGAGGAGC CAGCTACAGC 
TGCTGCCGTC CCCTTCTGGA CAAATGGCCC ACAACACTGA GCAGGCATCT GGGTGGCCCC 
TGCCAGGTTG ATGCCCACTG CTCTGCCGGC CACTCCTGCA TCTTTACCGT CTCAGGGACT 
TCCAGTTGCT GCCCCTTCCC AGAGGCCGTG GCATGCGGGG ATGGCCATCA CTGCTGCCCA 
CGGGGCTTCC ACTGCAGTGC AGACGGGCGA TCCTGCTTCC AAAGATCAGG TAACAACTCC 
GTGGGTGCCA TCCAGTGCCC TGATAGTCAG TTCGAATGCC CGGACTTCTC CACGTGCTGT 
GTTATGGTCG ATGGCTCCTG GGGGTGCTGC CCCATGCCCC AGGCTTCCTG CTGTGAAGAC 
AGGGTGCACT GCTGTCCGCA CGGTGCCTTC TGCGACCTGG TTCACACCCG CTGCATCACA 
CCCACGGGCA CCCACCCCCT GGCAAAGAAG CTCCCTGCCC AGAGGACTAA CAGGGCAGTG 
GCCTTGTCCA GCTCGGTCAT GTGTCCGGAC GCACGGTCCC GGTGCCCTGA TGGTTCTACC 
TGCTGTGAGC TGCCCAGTGG GAAGTATGGC TGCTGCCCAA TGCCCAACGC CACCTGCTGC 
TCCGATCACC TGCACTGCTG CCCCCAAGAC ACTGTGTGTG ACCTGATCCA GAGTAAGTGC 
CTCTCCAAGG AGAACGCTAC CACGGACCTC CTCACTAAGC TGCCTGCGCA CACAGTGGGG 
GATGTGAAAT GTGACATGGA GGTGAGCTGC CCAGATGGCT ATACCTGCTG CCGTCTACAG 
TCGGGGGCCT GGGGCTGCTG CCCTTTTACC CAGGCTGTGT GCTGTGAGGA CCACATACAC 
TGCTGTCCCG CGGGGTTTAC GTGTGACACG CAGAAGGGTA CCTGTGAACA GGGGCCCCAC 
CAGGTGCCCT GGATGGAGAA GGCCCCAGCT CACCTCAGCC TGCCAGACCC ACAAGCCTTG 
AAGAGAGATG TCCCCTGTGA TAATGTCAGC AGCTGTCCCT CCTCCGATAC CTGCTGCCAA 
CTCACGTCTG GGGAGTGGGG CTGCTGTCCA ATCCCAGAGG CTGTCTGCTG CTCGGACCAC 
CAGCACTGCT GCCCCCAGGG CTACACGTGT GTAGCTGAGG GGCAGTGTCA GCGAGGAAGC 
GAGATCGTGG CTGGACTGGA GAAGATGCCT GCCCGCCGGG CTTCCTTATC CCACCCCAGA 
GACATCGGCT GTGACCAGCA CACCAGCTGC CCGGTGGGGC AGACCTGCTG CCCGAGCCTG 
GGTGGGAGCT GGGCCTGCTG CCAGTTGCCC CATGCTGTGT GCTGCGAGGA TCGCCAGCAC 
TGCTGCCCGG CTGGCTACAC CTGCAACGTG AAGGCTCGAT CCTGCGAGAA GGAAGTGGTC 
TCTGCCCAGC CTGCCACCTT CCTGGCCCGT AGCCCTCACG TGGGTGTGAA GGACGTGGAG 
TGTGGGGAAG GACACTTCTG CCATGATAAC CAGACCTGCT GCCGAGACAA CCGACAGGGC 
TGGGCCTGCT GTCCCTACCG CCAGGGCGTC TGTTGTGCTG ATCGGCGCCA CTGCTGTCCT 
GCTGGCTTCC GCTGCGCAGC CAGGGGTACC AAGTGTTTGC GCAGGGAGGC CCCGCGCTGG 
GACGCCCCTT TGAGGGACCC AGCCTTGAGA CAGCTGCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005257310.1
CDS	302..2083
Translation	MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL

Target ORF information:

RefSeq Version	XM_005257253.1
Organism	Homo sapiens(human)
Definition	Homo sapiens granulin precursor (GRN), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005257253.1

ORF Insert Sequence:

ATGTGGACCC TGGTGAGCTG GGTGGCCTTA ACAGCAGGGC TGGTGGCTGG AACGCGGTGC 
CCAGATGGTC AGTTCTGCCC TGTGGCCTGC TGCCTGGACC CCGGAGGAGC CAGCTACAGC 
TGCTGCCGTC CCCTTCTGGA CAAATGGCCC ACAACACTGA GCAGGCATCT GGGTGGCCCC 
TGCCAGGTTG ATGCCCACTG CTCTGCCGGC CACTCCTGCA TCTTTACCGT CTCAGGGACT 
TCCAGTTGCT GCCCCTTCCC AGAGGCCGTG GCATGCGGGG ATGGCCATCA CTGCTGCCCA 
CGGGGCTTCC ACTGCAGTGC AGACGGGCGA TCCTGCTTCC AAAGATCAGG TAACAACTCC 
GTGGGTGCCA TCCAGTGCCC TGATAGTCAG TTCGAATGCC CGGACTTCTC CACGTGCTGT 
GTTATGGTCG ATGGCTCCTG GGGGTGCTGC CCCATGCCCC AGGCTTCCTG CTGTGAAGAC 
AGGGTGCACT GCTGTCCGCA CGGTGCCTTC TGCGACCTGG TTCACACCCG CTGCATCACA 
CCCACGGGCA CCCACCCCCT GGCAAAGAAG CTCCCTGCCC AGAGGACTAA CAGGGCAGTG 
GCCTTGTCCA GCTCGGTCAT GTGTCCGGAC GCACGGTCCC GGTGCCCTGA TGGTTCTACC 
TGCTGTGAGC TGCCCAGTGG GAAGTATGGC TGCTGCCCAA TGCCCAACGC CACCTGCTGC 
TCCGATCACC TGCACTGCTG CCCCCAAGAC ACTGTGTGTG ACCTGATCCA GAGTAAGTGC 
CTCTCCAAGG AGAACGCTAC CACGGACCTC CTCACTAAGC TGCCTGCGCA CACAGTGGGG 
GATGTGAAAT GTGACATGGA GGTGAGCTGC CCAGATGGCT ATACCTGCTG CCGTCTACAG 
TCGGGGGCCT GGGGCTGCTG CCCTTTTACC CAGGCTGTGT GCTGTGAGGA CCACATACAC 
TGCTGTCCCG CGGGGTTTAC GTGTGACACG CAGAAGGGTA CCTGTGAACA GGGGCCCCAC 
CAGGTGCCCT GGATGGAGAA GGCCCCAGCT CACCTCAGCC TGCCAGACCC ACAAGCCTTG 
AAGAGAGATG TCCCCTGTGA TAATGTCAGC AGCTGTCCCT CCTCCGATAC CTGCTGCCAA 
CTCACGTCTG GGGAGTGGGG CTGCTGTCCA ATCCCAGAGG CTGTCTGCTG CTCGGACCAC 
CAGCACTGCT GCCCCCAGGG CTACACGTGT GTAGCTGAGG GGCAGTGTCA GCGAGGAAGC 
GAGATCGTGG CTGGACTGGA GAAGATGCCT GCCCGCCGGG CTTCCTTATC CCACCCCAGA 
GACATCGGCT GTGACCAGCA CACCAGCTGC CCGGTGGGGC AGACCTGCTG CCCGAGCCTG 
GGTGGGAGCT GGGCCTGCTG CCAGTTGCCC CATGCTGTGT GCTGCGAGGA TCGCCAGCAC 
TGCTGCCCGG CTGGCTACAC CTGCAACGTG AAGGCTCGAT CCTGCGAGAA GGAAGTGGTC 
TCTGCCCAGC CTGCCACCTT CCTGGCCCGT AGCCCTCACG TGGGTGTGAA GGACGTGGAG 
TGTGGGGAAG GACACTTCTG CCATGATAAC CAGACCTGCT GCCGAGACAA CCGACAGGGC 
TGGGCCTGCT GTCCCTACCG CCAGGGCGTC TGTTGTGCTG ATCGGCGCCA CTGCTGTCCT 
GCTGGCTTCC GCTGCGCAGC CAGGGGTACC AAGTGTTTGC GCAGGGAGGC CCCGCGCTGG 
GACGCCCCTT TGAGGGACCC AGCCTTGAGA CAGCTGCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRN ( XM_024450730.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024306498.1 Homo sapiens granulin precursor (GRN), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu25975
Clone ID Related Accession (Same CDS sequence)	XM_005257253.1 , XM_024450730.1 , NM_002087.3
Accession Version	XM_024450730.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	progranulin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGACCC TGGTGAGCTG GGTGGCCTTA ACAGCAGGGC TGGTGGCTGG AACGCGGTGC 
CCAGATGGTC AGTTCTGCCC TGTGGCCTGC TGCCTGGACC CCGGAGGAGC CAGCTACAGC 
TGCTGCCGTC CCCTTCTGGA CAAATGGCCC ACAACACTGA GCAGGCATCT GGGTGGCCCC 
TGCCAGGTTG ATGCCCACTG CTCTGCCGGC CACTCCTGCA TCTTTACCGT CTCAGGGACT 
TCCAGTTGCT GCCCCTTCCC AGAGGCCGTG GCATGCGGGG ATGGCCATCA CTGCTGCCCA 
CGGGGCTTCC ACTGCAGTGC AGACGGGCGA TCCTGCTTCC AAAGATCAGG TAACAACTCC 
GTGGGTGCCA TCCAGTGCCC TGATAGTCAG TTCGAATGCC CGGACTTCTC CACGTGCTGT 
GTTATGGTCG ATGGCTCCTG GGGGTGCTGC CCCATGCCCC AGGCTTCCTG CTGTGAAGAC 
AGGGTGCACT GCTGTCCGCA CGGTGCCTTC TGCGACCTGG TTCACACCCG CTGCATCACA 
CCCACGGGCA CCCACCCCCT GGCAAAGAAG CTCCCTGCCC AGAGGACTAA CAGGGCAGTG 
GCCTTGTCCA GCTCGGTCAT GTGTCCGGAC GCACGGTCCC GGTGCCCTGA TGGTTCTACC 
TGCTGTGAGC TGCCCAGTGG GAAGTATGGC TGCTGCCCAA TGCCCAACGC CACCTGCTGC 
TCCGATCACC TGCACTGCTG CCCCCAAGAC ACTGTGTGTG ACCTGATCCA GAGTAAGTGC 
CTCTCCAAGG AGAACGCTAC CACGGACCTC CTCACTAAGC TGCCTGCGCA CACAGTGGGG 
GATGTGAAAT GTGACATGGA GGTGAGCTGC CCAGATGGCT ATACCTGCTG CCGTCTACAG 
TCGGGGGCCT GGGGCTGCTG CCCTTTTACC CAGGCTGTGT GCTGTGAGGA CCACATACAC 
TGCTGTCCCG CGGGGTTTAC GTGTGACACG CAGAAGGGTA CCTGTGAACA GGGGCCCCAC 
CAGGTGCCCT GGATGGAGAA GGCCCCAGCT CACCTCAGCC TGCCAGACCC ACAAGCCTTG 
AAGAGAGATG TCCCCTGTGA TAATGTCAGC AGCTGTCCCT CCTCCGATAC CTGCTGCCAA 
CTCACGTCTG GGGAGTGGGG CTGCTGTCCA ATCCCAGAGG CTGTCTGCTG CTCGGACCAC 
CAGCACTGCT GCCCCCAGGG CTACACGTGT GTAGCTGAGG GGCAGTGTCA GCGAGGAAGC 
GAGATCGTGG CTGGACTGGA GAAGATGCCT GCCCGCCGGG CTTCCTTATC CCACCCCAGA 
GACATCGGCT GTGACCAGCA CACCAGCTGC CCGGTGGGGC AGACCTGCTG CCCGAGCCTG 
GGTGGGAGCT GGGCCTGCTG CCAGTTGCCC CATGCTGTGT GCTGCGAGGA TCGCCAGCAC 
TGCTGCCCGG CTGGCTACAC CTGCAACGTG AAGGCTCGAT CCTGCGAGAA GGAAGTGGTC 
TCTGCCCAGC CTGCCACCTT CCTGGCCCGT AGCCCTCACG TGGGTGTGAA GGACGTGGAG 
TGTGGGGAAG GACACTTCTG CCATGATAAC CAGACCTGCT GCCGAGACAA CCGACAGGGC 
TGGGCCTGCT GTCCCTACCG CCAGGGCGTC TGTTGTGCTG ATCGGCGCCA CTGCTGTCCT 
GCTGGCTTCC GCTGCGCAGC CAGGGGTACC AAGTGTTTGC GCAGGGAGGC CCCGCGCTGG 
GACGCCCCTT TGAGGGACCC AGCCTTGAGA CAGCTGCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024306498.1
CDS	135..1916
Translation	MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL

Target ORF information:

RefSeq Version	XM_024450730.1
Organism	Homo sapiens(human)
Definition	Homo sapiens granulin precursor (GRN), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024450730.1

ORF Insert Sequence:

ATGTGGACCC TGGTGAGCTG GGTGGCCTTA ACAGCAGGGC TGGTGGCTGG AACGCGGTGC 
CCAGATGGTC AGTTCTGCCC TGTGGCCTGC TGCCTGGACC CCGGAGGAGC CAGCTACAGC 
TGCTGCCGTC CCCTTCTGGA CAAATGGCCC ACAACACTGA GCAGGCATCT GGGTGGCCCC 
TGCCAGGTTG ATGCCCACTG CTCTGCCGGC CACTCCTGCA TCTTTACCGT CTCAGGGACT 
TCCAGTTGCT GCCCCTTCCC AGAGGCCGTG GCATGCGGGG ATGGCCATCA CTGCTGCCCA 
CGGGGCTTCC ACTGCAGTGC AGACGGGCGA TCCTGCTTCC AAAGATCAGG TAACAACTCC 
GTGGGTGCCA TCCAGTGCCC TGATAGTCAG TTCGAATGCC CGGACTTCTC CACGTGCTGT 
GTTATGGTCG ATGGCTCCTG GGGGTGCTGC CCCATGCCCC AGGCTTCCTG CTGTGAAGAC 
AGGGTGCACT GCTGTCCGCA CGGTGCCTTC TGCGACCTGG TTCACACCCG CTGCATCACA 
CCCACGGGCA CCCACCCCCT GGCAAAGAAG CTCCCTGCCC AGAGGACTAA CAGGGCAGTG 
GCCTTGTCCA GCTCGGTCAT GTGTCCGGAC GCACGGTCCC GGTGCCCTGA TGGTTCTACC 
TGCTGTGAGC TGCCCAGTGG GAAGTATGGC TGCTGCCCAA TGCCCAACGC CACCTGCTGC 
TCCGATCACC TGCACTGCTG CCCCCAAGAC ACTGTGTGTG ACCTGATCCA GAGTAAGTGC 
CTCTCCAAGG AGAACGCTAC CACGGACCTC CTCACTAAGC TGCCTGCGCA CACAGTGGGG 
GATGTGAAAT GTGACATGGA GGTGAGCTGC CCAGATGGCT ATACCTGCTG CCGTCTACAG 
TCGGGGGCCT GGGGCTGCTG CCCTTTTACC CAGGCTGTGT GCTGTGAGGA CCACATACAC 
TGCTGTCCCG CGGGGTTTAC GTGTGACACG CAGAAGGGTA CCTGTGAACA GGGGCCCCAC 
CAGGTGCCCT GGATGGAGAA GGCCCCAGCT CACCTCAGCC TGCCAGACCC ACAAGCCTTG 
AAGAGAGATG TCCCCTGTGA TAATGTCAGC AGCTGTCCCT CCTCCGATAC CTGCTGCCAA 
CTCACGTCTG GGGAGTGGGG CTGCTGTCCA ATCCCAGAGG CTGTCTGCTG CTCGGACCAC 
CAGCACTGCT GCCCCCAGGG CTACACGTGT GTAGCTGAGG GGCAGTGTCA GCGAGGAAGC 
GAGATCGTGG CTGGACTGGA GAAGATGCCT GCCCGCCGGG CTTCCTTATC CCACCCCAGA 
GACATCGGCT GTGACCAGCA CACCAGCTGC CCGGTGGGGC AGACCTGCTG CCCGAGCCTG 
GGTGGGAGCT GGGCCTGCTG CCAGTTGCCC CATGCTGTGT GCTGCGAGGA TCGCCAGCAC 
TGCTGCCCGG CTGGCTACAC CTGCAACGTG AAGGCTCGAT CCTGCGAGAA GGAAGTGGTC 
TCTGCCCAGC CTGCCACCTT CCTGGCCCGT AGCCCTCACG TGGGTGTGAA GGACGTGGAG 
TGTGGGGAAG GACACTTCTG CCATGATAAC CAGACCTGCT GCCGAGACAA CCGACAGGGC 
TGGGCCTGCT GTCCCTACCG CCAGGGCGTC TGTTGTGCTG ATCGGCGCCA CTGCTGTCCT 
GCTGGCTTCC GCTGCGCAGC CAGGGGTACC AAGTGTTTGC GCAGGGAGGC CCCGCGCTGG 
GACGCCCCTT TGAGGGACCC AGCCTTGAGA CAGCTGCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression.
The Journal of biological chemistry289(37)25879-89(2014 Sep)
Capell A,Fellerer K,Haass C

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GRN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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