LAMTOR2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LAMTOR2
Entrez Gene ID	28956
Full Name	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Synonyms	ENDAP,HSPC003,MAPBPIP,MAPKSP1AP,ROBLD3,Ragulator2,p14
General protein information	Preferred Names late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Names ragulator complex protein LAMTOR2 MAPBP-interacting protein MAPKSP1 adaptor protein endosomal adaptor protein p14 late endosomal/lysosomal Mp1-interacting protein late endosomal/lysosomal adaptor and MAPK and MTOR activator 2 mitogen-activated protein-binding protein-interacting protein (MAPBPIP) roadblock domain containing 3 roadblock domain-containing protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q22
Summary	The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
Disorder MIM:	610389
Disorder Html:	Immunodeficiency due to defect in MAPBP-interacting protein, 610798 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_014017.3	NP_054736.1	ragulator complex protein LAMTOR2 isoform 1
NM_014017.4	NP_054736.1	ragulator complex protein LAMTOR2 isoform 1
NM_001145264.2	NP_001138736.1	ragulator complex protein LAMTOR2 isoform 2
NM_001145264.1	NP_001138736.1	ragulator complex protein LAMTOR2 isoform 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	lamtor2	NP_001003549.2
Xenopus tropicalis (tropical clawed frog)	lamtor2	NP_001005040.1
Pan troglodytes (chimpanzee)	LAMTOR2	XP_001163747.1
Gallus gallus (chicken)	LOC100859842	XP_003642666.2
Homo sapiens (human)	LAMTOR2	NP_054736.1
Canis lupus familiaris (dog)	LAMTOR2	XP_537247.1
Bos taurus (cattle)	LAMTOR2	NP_001029963.1
Mus musculus (house mouse)	Lamtor2	NP_112538.1
Drosophila melanogaster (fruit fly)	CG5189	NP_001137699.1
	LAMTOR2	XP_002801896.1
Rattus norvegicus (Norway rat)	Lamtor2	NP_001099911.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007213	XP_308572.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Rebsamen M, Pochini L, Stasyk T, de Ara?jo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G
Nature519(7544)477-81(2015 Mar)

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM
Science (New York, N.Y.)347(6218)188-94(2015 Jan)

Polymorphisms in the gene regions of the adaptor complex LAMTOR2/LAMTOR3 and their association with breast cancer risk.
De Araujo ME, Erhart G, Buck K, M?ller-Holzner E, Hubalek M, Fiegl H, Campa D, Canzian F, Eilber U, Chang-Claude J, Coassin S, Haun M, Kedenko L, Paulweber B, Reitsamer R, Himmel I, Flesch-Janys D, Lamina C, Kronenberg F, Huber LA, Kloss-Brandst?tter A
PloS one8(1)e53768(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identified polymorphisms in LAMTOR2 and LAMTOR3 do not seem to play a relevant role in breast cancer
Title: Polymorphisms in the gene regions of the adaptor complex LAMTOR2/LAMTOR3 and their association with breast cancer risk.

The ROBLD3 C-A, thorn23 mutation creates a 50SS capable of recruiting an inhibitory U1 snRNP complex leading to a failure of proper 30 end formation and rapid degradation of p14 mRNA.
Title: A complex immunodeficiency is based on U1 snRNP-mediated poly(A) site suppression.

simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1, co-regulated by Cbl-CIN85 and Endophilin A1
Title: Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin.

A complex encoded by the MAPKSP1, ROBLD3, and c11orf59 genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation
Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

The following LAMTOR2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LAMTOR2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22652	NM_014017.4 Latest version!	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10986	NM_001145264.2 Latest version!	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu22652	NM_014017.3	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10986	NM_001145264.1	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LAMTOR2 ( NM_014017.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_054736.1 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22652
Clone ID Related Accession (Same CDS sequence)	NM_014017.3 , NM_014017.4
Accession Version	NM_014017.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Homo sapiens(human)
Product	ragulator complex protein LAMTOR2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355388.30, BC024190.2 and CA438137.1. This sequence is a reference standard in the RefSeqGene project. On Feb 18, 2009 this sequence version replaced NM_014017.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CN360668.1, SRR1163658.484199.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCGCC CCAAGGCTTT GACCCAGGTG CTAAGCCAAG CCAACACTGG AGGCGTCCAG 
AGCACCCTGC TGCTGAATAA CGAGGGATCA CTGCTGGCCT ACTCTGGTTA CGGGGACACT 
GACGCCCGGG TCACCGCTGC CATAGCCAGT AACATCTGGG CCGCCTACGA CCGGAACGGG 
AACCAAGCGT TTAATGAAGA CAATCTCAAA TTCATCCTCA TGGACTGCAT GGAGGGCCGT 
GTAGCCATCA CCCGAGTGGC CAACCTTCTG CTGTGTATGT ATGCCAAGGA GACCGTGGGC 
TTTGGAATGC TCAAGGCCAA GGCCCAGGCT TTGGTGCAGT ACCTGGAGGA GCCCCTCACC 
CAAGTGGCGG CATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054736.1
CDS	165..542
Translation	MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS

Target ORF information:

RefSeq Version	NM_014017.3
Organism	Homo sapiens(human)
Definition	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014017.3

ORF Insert Sequence:

ATGCTGCGCC CCAAGGCTTT GACCCAGGTG CTAAGCCAAG CCAACACTGG AGGCGTCCAG 
AGCACCCTGC TGCTGAATAA CGAGGGATCA CTGCTGGCCT ACTCTGGTTA CGGGGACACT 
GACGCCCGGG TCACCGCTGC CATAGCCAGT AACATCTGGG CCGCCTACGA CCGGAACGGG 
AACCAAGCGT TTAATGAAGA CAATCTCAAA TTCATCCTCA TGGACTGCAT GGAGGGCCGT 
GTAGCCATCA CCCGAGTGGC CAACCTTCTG CTGTGTATGT ATGCCAAGGA GACCGTGGGC 
TTTGGAATGC TCAAGGCCAA GGCCCAGGCT TTGGTGCAGT ACCTGGAGGA GCCCCTCACC 
CAAGTGGCGG CATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAMTOR2 ( NM_014017.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_054736.1 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22652
Clone ID Related Accession (Same CDS sequence)	NM_014017.3 , NM_014017.4
Accession Version	NM_014017.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	ragulator complex protein LAMTOR2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355388.30, BC024190.2 and CA438137.1. On Aug 31, 2019 this sequence version replaced NM_014017.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CN360668.1, BG708390.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCGCC CCAAGGCTTT GACCCAGGTG CTAAGCCAAG CCAACACTGG AGGCGTCCAG 
AGCACCCTGC TGCTGAATAA CGAGGGATCA CTGCTGGCCT ACTCTGGTTA CGGGGACACT 
GACGCCCGGG TCACCGCTGC CATAGCCAGT AACATCTGGG CCGCCTACGA CCGGAACGGG 
AACCAAGCGT TTAATGAAGA CAATCTCAAA TTCATCCTCA TGGACTGCAT GGAGGGCCGT 
GTAGCCATCA CCCGAGTGGC CAACCTTCTG CTGTGTATGT ATGCCAAGGA GACCGTGGGC 
TTTGGAATGC TCAAGGCCAA GGCCCAGGCT TTGGTGCAGT ACCTGGAGGA GCCCCTCACC 
CAAGTGGCGG CATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054736.1
CDS	109..486
Translation	MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS

Target ORF information:

RefSeq Version	NM_014017.4
Organism	Homo sapiens(human)
Definition	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014017.4

ORF Insert Sequence:

ATGCTGCGCC CCAAGGCTTT GACCCAGGTG CTAAGCCAAG CCAACACTGG AGGCGTCCAG 
AGCACCCTGC TGCTGAATAA CGAGGGATCA CTGCTGGCCT ACTCTGGTTA CGGGGACACT 
GACGCCCGGG TCACCGCTGC CATAGCCAGT AACATCTGGG CCGCCTACGA CCGGAACGGG 
AACCAAGCGT TTAATGAAGA CAATCTCAAA TTCATCCTCA TGGACTGCAT GGAGGGCCGT 
GTAGCCATCA CCCGAGTGGC CAACCTTCTG CTGTGTATGT ATGCCAAGGA GACCGTGGGC 
TTTGGAATGC TCAAGGCCAA GGCCCAGGCT TTGGTGCAGT ACCTGGAGGA GCCCCTCACC 
CAAGTGGCGG CATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAMTOR2 ( NM_001145264.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138736.1 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10986
Clone ID Related Accession (Same CDS sequence)	NM_001145264.2 , NM_001145264.1
Accession Version	NM_001145264.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	ragulator complex protein LAMTOR2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355388.30 and BU184679.1. On Jun 2, 2019 this sequence version replaced NM_001145264.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU184679.1, BQ683816.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCGCC CCAAGGCTTT GACCCAGGTG CTAAGCCAAG CCAACACTGG AGGCGTCCAG 
AGCACCCTGC TGCTGAATAA CGAGGGATCA CTGCTGGCCT ACTCTGGTTA CGGGGACACT 
GACGCCCGGG TCACCGCTGC CATAGCCAGT AACATCTGGG CCGCCTACGA CCGGAACGGG 
AACCAAGCGT TTAATGAAGA CAATCTCAAA TTCATCCTCA TGGACTGCAT GGCCCAGGCT 
TTGGTGCAGT ACCTGGAGGA GCCCCTCACC CAAGTGGCGG CATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138736.1
CDS	109..396
Translation	MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMAQALVQYLEEPLTQVAAS

Target ORF information:

RefSeq Version	NM_001145264.2
Organism	Homo sapiens(human)
Definition	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145264.2

ORF Insert Sequence:

ATGCTGCGCC CCAAGGCTTT GACCCAGGTG CTAAGCCAAG CCAACACTGG AGGCGTCCAG 
AGCACCCTGC TGCTGAATAA CGAGGGATCA CTGCTGGCCT ACTCTGGTTA CGGGGACACT 
GACGCCCGGG TCACCGCTGC CATAGCCAGT AACATCTGGG CCGCCTACGA CCGGAACGGG 
AACCAAGCGT TTAATGAAGA CAATCTCAAA TTCATCCTCA TGGACTGCAT GGCCCAGGCT 
TTGGTGCAGT ACCTGGAGGA GCCCCTCACC CAAGTGGCGG CATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAMTOR2 ( NM_001145264.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138736.1 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10986
Clone ID Related Accession (Same CDS sequence)	NM_001145264.2 , NM_001145264.1
Accession Version	NM_001145264.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-27
Organism	Homo sapiens(human)
Product	ragulator complex protein LAMTOR2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355388.30, BU184679.1 and CA438137.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ676838.1, BQ683816.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCGCC CCAAGGCTTT GACCCAGGTG CTAAGCCAAG CCAACACTGG AGGCGTCCAG 
AGCACCCTGC TGCTGAATAA CGAGGGATCA CTGCTGGCCT ACTCTGGTTA CGGGGACACT 
GACGCCCGGG TCACCGCTGC CATAGCCAGT AACATCTGGG CCGCCTACGA CCGGAACGGG 
AACCAAGCGT TTAATGAAGA CAATCTCAAA TTCATCCTCA TGGACTGCAT GGCCCAGGCT 
TTGGTGCAGT ACCTGGAGGA GCCCCTCACC CAAGTGGCGG CATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138736.1
CDS	165..452
Translation	MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMAQALVQYLEEPLTQVAAS

Target ORF information:

RefSeq Version	NM_001145264.1
Organism	Homo sapiens(human)
Definition	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145264.1

ORF Insert Sequence:

ATGCTGCGCC CCAAGGCTTT GACCCAGGTG CTAAGCCAAG CCAACACTGG AGGCGTCCAG 
AGCACCCTGC TGCTGAATAA CGAGGGATCA CTGCTGGCCT ACTCTGGTTA CGGGGACACT 
GACGCCCGGG TCACCGCTGC CATAGCCAGT AACATCTGGG CCGCCTACGA CCGGAACGGG 
AACCAAGCGT TTAATGAAGA CAATCTCAAA TTCATCCTCA TGGACTGCAT GGCCCAGGCT 
TTGGTGCAGT ACCTGGAGGA GCCCCTCACC CAAGTGGCGG CATCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Nature519(7544)477-81(2015 Mar)
Rebsamen M,Pochini L,Stasyk T,de Ara?jo ME,Galluccio M,Kandasamy RK,Snijder B,Fauster A,Rudashevskaya EL,Bruckner M,Scorzoni S,Filipek PA,Huber KV,Bigenzahn JW,Heinz LX,Kraft C,Bennett KL,Indiveri C,Huber LA,Superti-Furga G

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Science (New York, N.Y.)347(6218)188-94(2015 Jan)
Wang S,Tsun ZY,Wolfson RL,Shen K,Wyant GA,Plovanich ME,Yuan ED,Jones TD,Chantranupong L,Comb W,Wang T,Bar-Peled L,Zoncu R,Straub C,Kim C,Park J,Sabatini BL,Sabatini DM

Polymorphisms in the gene regions of the adaptor complex LAMTOR2/LAMTOR3 and their association with breast cancer risk.
PloS one8(1)e53768(2013)
De Araujo ME,Erhart G,Buck K,M?ller-Holzner E,Hubalek M,Fiegl H,Campa D,Canzian F,Eilber U,Chang-Claude J,Coassin S,Haun M,Kedenko L,Paulweber B,Reitsamer R,Himmel I,Flesch-Janys D,Lamina C,Kronenberg F,Huber LA,Kloss-Brandst?tter A

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LAMTOR2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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電話

FAX

オンラインフォーム

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