GRIA3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GRIA3
Entrez Gene ID	2892
Full Name	glutamate ionotropic receptor AMPA type subunit 3
Synonyms	GLUR-C,GLUR-K3,GLUR3,GLURC,GluA3,MRX94
General protein information	Preferred Names glutamate ionotropic receptor AMPA type subunit 3 Names glutamate receptor 3 AMPA-selective glutamate receptor 3 dJ1171F9.1 gluR-3 glutamate receptor C glutamate receptor subunit 3 glutamate receptor, ionotrophic, AMPA 3 glutamate receptor, ionotropic, AMPA 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq25
Summary	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008].
Disorder MIM:	305915
Disorder Html:	Mental retardation, X-linked 94, 300699 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_007325.4	NP_015564.4	glutamate receptor 3 isoform 1 precursor
NM_007325.5	NP_015564.5	glutamate receptor 3 isoform 1 precursor
NM_001256743.1	NP_001243672.1	glutamate receptor 3 isoform 3 precursor
NM_001256743.2	NP_001243672.1	glutamate receptor 3 isoform 3 precursor
NM_000828.4	NP_000819.3	glutamate receptor 3 isoform 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GRIA3	XP_003317712.1
Danio rerio (zebrafish)	gria3b	NP_938174.1
Bos taurus (cattle)	GRIA3	NP_001192988.1
Gallus gallus (chicken)	GRIA3	NP_990546.2
Xenopus tropicalis (tropical clawed frog)	gria3	NP_001106494.1
Canis lupus familiaris (dog)	GRIA3	XP_005641824.1
Drosophila melanogaster (fruit fly)	Glu-RI	NP_476855.1
Homo sapiens (human)	GRIA3	NP_015564.4
	GRIA3	XP_001088327.1
Drosophila melanogaster (fruit fly)	Glu-RIB	NP_001261622.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006027	XP_316066.4
Caenorhabditis elegans (roundworm)	glr-2	NP_001021114.1
Mus musculus (house mouse)	Gria3	NP_001268858.1
Rattus norvegicus (Norway rat)	Gria3	NP_116785.2
Danio rerio (zebrafish)	gria3a	NP_938153.1
Caenorhabditis elegans (roundworm)	glr-1	NP_498887.2

Gene Ontology
Bibliography

Related articles in PubMed

Genetic variation of GRIA3 gene is associated with vulnerability to methamphetamine dependence and its associated psychosis.
Iamjan SA, Thanoi S, Watiktinkorn P, Reynolds GP, Nudmamud-Thanoi S
Journal of psychopharmacology (Oxford, England)269881117750153(2018 Jan)

A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.
Davies B, Brown LA, Cais O, Watson J, Clayton AJ, Chang VT, Biggs D, Preece C, Hernandez-Pliego P, Krohn J, Bhomra A, Twigg SRF, Rimmer A, Kanapin A, , Sen A, Zaiwalla Z, McVean G, Foster R, Donnelly P, Taylor JC, Blair E, Nutt D, Aricescu AR, Greger IH, Peirson SN, Flint J, Martin HC
Human molecular genetics26(20)3869-3882(2017 Oct)

Anti-AMPA GluA3 antibodies in Frontotemporal dementia: a new molecular target.
Borroni B, Stanic J, Verpelli C, Mellone M, Bonomi E, Alberici A, Bernasconi P, Culotta L, Zianni E, Archetti S, Manes M, Gazzina S, Ghidoni R, Benussi L, Stuani C, Di Luca M, Sala C, Buratti E, Padovani A, Gardoni F
Scientific reports7(1)6723(2017 Jul)

MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway.
Wei CH, Wu G, Cai Q, Gao XC, Tong F, Zhou R, Zhang RG, Dong JH, Hu Y, Dong XR
Journal of hematology & oncology10(1)125(2017 Jun)

AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women.
Bhandage AK, Jin Z, Hellgren C, Korol SV, Nowak K, Williamsson L, Sundstr?m-Poromaa I, Birnir B
Journal of neuroimmunology30551-58(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-330-3p up-regulated the total DNA methylation in non-small cell lung cancer cells, and co-IP-demonstrated GRIA3 was directly related with DNMT1 and DNMT3A. GRIA3 is a direct target of miR-330-3p.
Title: MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway.

This study showed the lower GluA3 mRNA levels in pregnant women.
Title: AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women.

the impaired surface expression of homomeric GluA3 receptors is caused by nonproductive assembly and aggregation to which LBD residues Tyr-454 and Arg-461 strongly contribute.
Title: Aggregation Limits Surface Expression of Homomeric GluA3 Receptors.

This study demonstrated that the GRIA3 protein was altered in auditory cortex patient with schizophreia.
Title: Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.

The N-terminal domain modulates alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization.
Title: The N-terminal domain modulates ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization.

The following GRIA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GRIA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26723	NM_007325.4 Latest version!	Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
OHu26990	NM_001256743.2 Latest version!	Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu26937	NM_000828.4 Latest version!	Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu108592	NM_007325.5 Latest version!	Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
View Old Accession Versions >>
OHu26990	NM_001256743.1	Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GRIA3 ( NM_007325.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_015564.4 Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26723
Clone ID Related Accession (Same CDS sequence)	NM_007325.4
Accession Version	NM_007325.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2685bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	glutamate receptor 3 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA191279.1, BC117464.1, DA180344.1, U10301.1, DA158269.1, DA179917.1, BY799542.2, DB505790.1, AW166130.1 and BE504553.1. This sequence is a reference standard in the RefSeqGene project. On Dec 20, 2007 this sequence version replaced NM_007325.3. Transcript Variant: This variant (1) encodes isoform 1 (also known as flip isoform). RNA editing (AGA->GGA) changes Arg775Gly. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.137683.1, SRR1803611.238104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## undergoes RNA editing :: PMID: 10688364, 7992055 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGGC AGAAGAAAAT GGGGCAAAGC GTGCTCCGGG CGGTCTTCTT TTTAGTCCTG 
GGGCTTTTGG GTCATTCTCA CGGAGGATTC CCCAACACCA TCAGCATAGG TGGACTTTTC 
ATGAGAAACA CAGTGCAGGA GCACAGCGCT TTCCGCTTTG CCGTGCAGTT ATACAACACC 
AACCAGAACA CCACCGAGAA GCCCTTCCAT TTGAATTACC ACGTAGATCA CTTGGATTCC 
TCCAATAGTT TTTCCGTGAC AAATGCTTTC TGCTCCCAGT TCTCGAGAGG GGTGTATGCC 
ATCTTTGGAT TCTATGACCA GATGTCAATG AACACCCTGA CCTCCTTCTG TGGGGCCCTG 
CACACATCCT TTGTTACGCC TAGCTTCCCC ACTGACGCAG ATGTGCAGTT TGTCATCCAG 
ATGCGCCCAG CCTTGAAGGG CGCTATTCTG AGTCTTCTGG GTCATTACAA GTGGGAGAAG 
TTTGTGTACC TCTATGACAC AGAACGAGGA TTTTCCATCC TCCAAGCGAT TATGGAAGCA 
GCAGTGCAAA ACAACTGGCA AGTAACAGCA AGGTCTGTGG GAAACATAAA GGACGTCCAA 
GAATTCAGGC GCATCATTGA AGAAATGGAC AGGAGGCAGG AAAAGCGATA CTTGATTGAC 
TGCGAAGTCG AAAGGATTAA CACAATTTTG GAACAGGTTG TGATCCTAGG GAAACACTCA 
AGAGGTTATC ACTACATGCT CGCTAACCTG GGTTTTACTG ATATTTTACT GGAAAGAGTC 
ATGCATGGGG GAGCCAACAT TACAGGTTTC CAGATTGTCA ACAATGAAAA CCCTATGGTT 
CAGCAGTTCA TACAGCGCTG GGTGAGGCTG GATGAAAGGG AATTCCCTGA AGCCAAGAAT 
GCACCACTAA AGTATACATC TGCATTGACA CACGACGCAA TACTGGTCAT AGCAGAAGCT 
TTCCGCTACC TGAGGAGGCA GCGAGTAGAT GTGTCCCGGA GAGGAAGTGC TGGAGACTGC 
TTAGCAAATC CTGCTGTGCC CTGGAGTCAA GGAATTGATA TTGAGAGAGC TCTGAAAATG 
GTGCAAGTAC AAGGAATGAC TGGAAATATT CAATTTGACA CTTATGGACG TAGGACAAAT 
TATACCATCG ATGTGTATGA AATGAAAGTC AGTGGCTCTC GAAAAGCTGG CTACTGGAAT 
GAGTATGAAA GGTTTGTGCC TTTCTCAGAT CAGCAAATCA GCAATGACAG TGCATCCTCA 
GAGAATCGGA CCATAGTAGT GACTACCATT CTGGAATCAC CATATGTAAT GTACAAGAAG 
AACCATGAGC AACTGGAAGG AAATGAACGA TATGAAGGCT ATTGTGTAGA CCTAGCCTAT 
GAAATAGCCA AACATGTAAG GATCAAATAC AAATTGTCCA TCGTTGGTGA CGGGAAATAT 
GGTGCAAGGG ATCCAGAGAC TAAAATATGG AACGGCATGG TTGGGGAACT TGTCTATGGG 
AGAGCTGATA TAGCTGTTGC TCCACTCACT ATAACATTGG TCCGTGAAGA AGTCATAGAT 
TTTTCAAAGC CATTCATGAG CCTGGGCATC TCCATCATGA TAAAGAAGCC TCAGAAATCA 
AAACCAGGCG TATTCTCATT TCTGGATCCC CTGGCTTATG AAATCTGGAT GTGCATTGTC 
TTTGCTTACA TTGGAGTCAG CGTAGTTCTT TTCCTAGTCA GCAGGTTCAG TCCTTATGAA 
TGGCACTTGG AAGACAACAA TGAAGAACCT CGTGACCCAC AAAGTCCTCC TGATCCTCCA 
AATGAATTTG GAATATTTAA CAGTCTTTGG TTTTCCTTGG GTGCCTTTAT GCAGCAAGGA 
TGTGATATTT CTCCAAGATC ACTCTCCGGG CGCATTGTTG GAGGGGTTTG GTGGTTCTTC 
ACCCTGATCA TAATTTCTTC CTATACTGCC AATCTCGCTG CTTTCCTGAC TGTGGAGAGG 
ATGGTTTCTC CCATAGAGAG TGCTGAAGAC TTAGCTAAAC AGACTGAAAT TGCATATGGG 
ACCCTGGACT CCGGTTCAAC AAAAGAATTT TTCAGAAGAT CCAAAATTGC TGTGTACGAG 
AAAATGTGGT CTTACATGAA ATCAGCGGAG CCATCTGTGT TTACCAAAAC AACAGCAGAC 
GGAGTGGCCC GAGTGCGAAA GTCCAAGGGA AAGTTCGCCT TCCTGCTGGA GTCAACCATG 
AATGAGTACA TTGAGCAGAG AAAACCATGT GATACGATGA AAGTTGGTGG AAATCTGGAT 
TCCAAAGGCT ATGGTGTGGC AACCCCTAAA GGCTCAGCAT TAGGAACGCC TGTAAACCTT 
GCAGTATTGA AACTCAGTGA ACAAGGCATC TTAGACAAGC TGAAAAACAA ATGGTGGTAC 
GATAAGGGGG AATGTGGAGC CAAGGACTCC GGGAGTAAGG ACAAGACCAG CGCTCTGAGC 
CTGAGCAATG TGGCAGGCGT TTTCTATATA CTTGTCGGAG GTCTGGGGCT GGCCATGATG 
GTGGCTTTGA TAGAATTCTG TTACAAATCA CGGGCAGAGT CCAAACGCAT GAAACTCACA 
AAGAACACCC AAAACTTTAA GCCTGCTCCT GCCACCAACA CTCAGAATTA TGCTACATAC 
AGAGAAGGCT ACAACGTGTA TGGAACAGAG AGTGTTAAGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_015564.4
CDS	294..2978
Translation	MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI

Target ORF information:

RefSeq Version	NM_007325.4
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007325.4

ORF Insert Sequence:

ATGGCCAGGC AGAAGAAAAT GGGGCAAAGC GTGCTCCGGG CGGTCTTCTT TTTAGTCCTG 
GGGCTTTTGG GTCATTCTCA CGGAGGATTC CCCAACACCA TCAGCATAGG TGGACTTTTC 
ATGAGAAACA CAGTGCAGGA GCACAGCGCT TTCCGCTTTG CCGTGCAGTT ATACAACACC 
AACCAGAACA CCACCGAGAA GCCCTTCCAT TTGAATTACC ACGTAGATCA CTTGGATTCC 
TCCAATAGTT TTTCCGTGAC AAATGCTTTC TGCTCCCAGT TCTCGAGAGG GGTGTATGCC 
ATCTTTGGAT TCTATGACCA GATGTCAATG AACACCCTGA CCTCCTTCTG TGGGGCCCTG 
CACACATCCT TTGTTACGCC TAGCTTCCCC ACTGACGCAG ATGTGCAGTT TGTCATCCAG 
ATGCGCCCAG CCTTGAAGGG CGCTATTCTG AGTCTTCTGG GTCATTACAA GTGGGAGAAG 
TTTGTGTACC TCTATGACAC AGAACGAGGA TTTTCCATCC TCCAAGCGAT TATGGAAGCA 
GCAGTGCAAA ACAACTGGCA AGTAACAGCA AGGTCTGTGG GAAACATAAA GGACGTCCAA 
GAATTCAGGC GCATCATTGA AGAAATGGAC AGGAGGCAGG AAAAGCGATA CTTGATTGAC 
TGCGAAGTCG AAAGGATTAA CACAATTTTG GAACAGGTTG TGATCCTAGG GAAACACTCA 
AGAGGTTATC ACTACATGCT CGCTAACCTG GGTTTTACTG ATATTTTACT GGAAAGAGTC 
ATGCATGGGG GAGCCAACAT TACAGGTTTC CAGATTGTCA ACAATGAAAA CCCTATGGTT 
CAGCAGTTCA TACAGCGCTG GGTGAGGCTG GATGAAAGGG AATTCCCTGA AGCCAAGAAT 
GCACCACTAA AGTATACATC TGCATTGACA CACGACGCAA TACTGGTCAT AGCAGAAGCT 
TTCCGCTACC TGAGGAGGCA GCGAGTAGAT GTGTCCCGGA GAGGAAGTGC TGGAGACTGC 
TTAGCAAATC CTGCTGTGCC CTGGAGTCAA GGAATTGATA TTGAGAGAGC TCTGAAAATG 
GTGCAAGTAC AAGGAATGAC TGGAAATATT CAATTTGACA CTTATGGACG TAGGACAAAT 
TATACCATCG ATGTGTATGA AATGAAAGTC AGTGGCTCTC GAAAAGCTGG CTACTGGAAT 
GAGTATGAAA GGTTTGTGCC TTTCTCAGAT CAGCAAATCA GCAATGACAG TGCATCCTCA 
GAGAATCGGA CCATAGTAGT GACTACCATT CTGGAATCAC CATATGTAAT GTACAAGAAG 
AACCATGAGC AACTGGAAGG AAATGAACGA TATGAAGGCT ATTGTGTAGA CCTAGCCTAT 
GAAATAGCCA AACATGTAAG GATCAAATAC AAATTGTCCA TCGTTGGTGA CGGGAAATAT 
GGTGCAAGGG ATCCAGAGAC TAAAATATGG AACGGCATGG TTGGGGAACT TGTCTATGGG 
AGAGCTGATA TAGCTGTTGC TCCACTCACT ATAACATTGG TCCGTGAAGA AGTCATAGAT 
TTTTCAAAGC CATTCATGAG CCTGGGCATC TCCATCATGA TAAAGAAGCC TCAGAAATCA 
AAACCAGGCG TATTCTCATT TCTGGATCCC CTGGCTTATG AAATCTGGAT GTGCATTGTC 
TTTGCTTACA TTGGAGTCAG CGTAGTTCTT TTCCTAGTCA GCAGGTTCAG TCCTTATGAA 
TGGCACTTGG AAGACAACAA TGAAGAACCT CGTGACCCAC AAAGTCCTCC TGATCCTCCA 
AATGAATTTG GAATATTTAA CAGTCTTTGG TTTTCCTTGG GTGCCTTTAT GCAGCAAGGA 
TGTGATATTT CTCCAAGATC ACTCTCCGGG CGCATTGTTG GAGGGGTTTG GTGGTTCTTC 
ACCCTGATCA TAATTTCTTC CTATACTGCC AATCTCGCTG CTTTCCTGAC TGTGGAGAGG 
ATGGTTTCTC CCATAGAGAG TGCTGAAGAC TTAGCTAAAC AGACTGAAAT TGCATATGGG 
ACCCTGGACT CCGGTTCAAC AAAAGAATTT TTCAGAAGAT CCAAAATTGC TGTGTACGAG 
AAAATGTGGT CTTACATGAA ATCAGCGGAG CCATCTGTGT TTACCAAAAC AACAGCAGAC 
GGAGTGGCCC GAGTGCGAAA GTCCAAGGGA AAGTTCGCCT TCCTGCTGGA GTCAACCATG 
AATGAGTACA TTGAGCAGAG AAAACCATGT GATACGATGA AAGTTGGTGG AAATCTGGAT 
TCCAAAGGCT ATGGTGTGGC AACCCCTAAA GGCTCAGCAT TAGGAACGCC TGTAAACCTT 
GCAGTATTGA AACTCAGTGA ACAAGGCATC TTAGACAAGC TGAAAAACAA ATGGTGGTAC 
GATAAGGGGG AATGTGGAGC CAAGGACTCC GGGAGTAAGG ACAAGACCAG CGCTCTGAGC 
CTGAGCAATG TGGCAGGCGT TTTCTATATA CTTGTCGGAG GTCTGGGGCT GGCCATGATG 
GTGGCTTTGA TAGAATTCTG TTACAAATCA CGGGCAGAGT CCAAACGCAT GAAACTCACA 
AAGAACACCC AAAACTTTAA GCCTGCTCCT GCCACCAACA CTCAGAATTA TGCTACATAC 
AGAGAAGGCT ACAACGTGTA TGGAACAGAG AGTGTTAAGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRIA3 ( NM_001256743.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243672.1 Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu26990
Clone ID Related Accession (Same CDS sequence)	NM_001256743.1 , NM_001256743.2
Accession Version	NM_001256743.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	glutamate receptor 3 isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA191279.1 and BC032004.1. Transcript Variant: This variant (3) lacks several exons and includes alternate 3' exons compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032004.1, BG680842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## undergoes RNA editing :: PMID: 10688364, 7992055 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGGC AGAAGAAAAT GGGGCAAAGC GTGCTCCGGG CGGTCTTCTT TTTAGTCCTG 
GGGCTTTTGG GTCATTCTCA CGGAGGATTC CCCAACACCA TCAGCATAGG TGGACTTTTC 
ATGAGAAACA CAGTGCAGGA GCACAGCGCT TTCCGCTTTG CCGTGCAGTT ATACAACACC 
AACCAGAACA CCACCGAGAA GCCCTTCCAT TTGAATTACC ACGTAGATCA CTTGGATTCC 
TCCAATAGTT TTTCCGTGAC AAATGCTTGT CCTGCTGAAA GGGACTACCT GCCTTGGCCA 
GGAAGCATCA GGGAAAACAA TTGGACAGCT CTGCCGTGCT GCAAAGATCA TGGGCTGCTG 
CACCTAAAAT GTTCACCAGG TGGGGCCCGC CAAAACTGGG CCTATTGTAT CTGGGGCGTT 
ACAGGTGAAC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243672.1
CDS	294..728
Translation	MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNACPAERDYLPWPGSIRENNWTALPCCKDHGLLHLKCSPGGARQNWAYCIWGVTGEL

Target ORF information:

RefSeq Version	NM_001256743.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256743.1

ORF Insert Sequence:

ATGGCCAGGC AGAAGAAAAT GGGGCAAAGC GTGCTCCGGG CGGTCTTCTT TTTAGTCCTG 
GGGCTTTTGG GTCATTCTCA CGGAGGATTC CCCAACACCA TCAGCATAGG TGGACTTTTC 
ATGAGAAACA CAGTGCAGGA GCACAGCGCT TTCCGCTTTG CCGTGCAGTT ATACAACACC 
AACCAGAACA CCACCGAGAA GCCCTTCCAT TTGAATTACC ACGTAGATCA CTTGGATTCC 
TCCAATAGTT TTTCCGTGAC AAATGCTTGT CCTGCTGAAA GGGACTACCT GCCTTGGCCA 
GGAAGCATCA GGGAAAACAA TTGGACAGCT CTGCCGTGCT GCAAAGATCA TGGGCTGCTG 
CACCTAAAAT GTTCACCAGG TGGGGCCCGC CAAAACTGGG CCTATTGTAT CTGGGGCGTT 
ACAGGTGAAC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRIA3 ( NM_001256743.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243672.1 Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu26990
Clone ID Related Accession (Same CDS sequence)	NM_001256743.1 , NM_001256743.2
Accession Version	NM_001256743.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	glutamate receptor 3 isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA191279.1 and BC032004.1. On May 31, 2019 this sequence version replaced NM_001256743.1. Transcript Variant: This variant (3) lacks several exons and includes alternate 3' exons compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032004.1, CA948553.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## undergoes RNA editing :: PMID: 10688364, 7992055 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGGC AGAAGAAAAT GGGGCAAAGC GTGCTCCGGG CGGTCTTCTT TTTAGTCCTG 
GGGCTTTTGG GTCATTCTCA CGGAGGATTC CCCAACACCA TCAGCATAGG TGGACTTTTC 
ATGAGAAACA CAGTGCAGGA GCACAGCGCT TTCCGCTTTG CCGTGCAGTT ATACAACACC 
AACCAGAACA CCACCGAGAA GCCCTTCCAT TTGAATTACC ACGTAGATCA CTTGGATTCC 
TCCAATAGTT TTTCCGTGAC AAATGCTTGT CCTGCTGAAA GGGACTACCT GCCTTGGCCA 
GGAAGCATCA GGGAAAACAA TTGGACAGCT CTGCCGTGCT GCAAAGATCA TGGGCTGCTG 
CACCTAAAAT GTTCACCAGG TGGGGCCCGC CAAAACTGGG CCTATTGTAT CTGGGGCGTT 
ACAGGTGAAC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243672.1
CDS	259..693
Translation	MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNACPAERDYLPWPGSIRENNWTALPCCKDHGLLHLKCSPGGARQNWAYCIWGVTGEL

Target ORF information:

RefSeq Version	NM_001256743.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256743.2

ORF Insert Sequence:

ATGGCCAGGC AGAAGAAAAT GGGGCAAAGC GTGCTCCGGG CGGTCTTCTT TTTAGTCCTG 
GGGCTTTTGG GTCATTCTCA CGGAGGATTC CCCAACACCA TCAGCATAGG TGGACTTTTC 
ATGAGAAACA CAGTGCAGGA GCACAGCGCT TTCCGCTTTG CCGTGCAGTT ATACAACACC 
AACCAGAACA CCACCGAGAA GCCCTTCCAT TTGAATTACC ACGTAGATCA CTTGGATTCC 
TCCAATAGTT TTTCCGTGAC AAATGCTTGT CCTGCTGAAA GGGACTACCT GCCTTGGCCA 
GGAAGCATCA GGGAAAACAA TTGGACAGCT CTGCCGTGCT GCAAAGATCA TGGGCTGCTG 
CACCTAAAAT GTTCACCAGG TGGGGCCCGC CAAAACTGGG CCTATTGTAT CTGGGGCGTT 
ACAGGTGAAC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRIA3 ( NM_000828.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000819.3 Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26937
Clone ID Related Accession (Same CDS sequence)	NM_000828.4
Accession Version	NM_000828.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2685bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	glutamate receptor 3 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA191279.1, BC117464.1, DA180344.1, U10302.1, DA158269.1, DA179917.1, BY799542.2, DB505790.1, AW166130.1 and BE504553.1. On Dec 20, 2007 this sequence version replaced NM_000828.3. Transcript Variant: This variant (2) uses an alternate internal coding exon compared to transcript variant 1, and encodes an isoform (2, also known as flop isoform) that is the same length, but with a few amino acid differences from isoform 1. RNA editing (AGA->GGA) changes Arg775Gly. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.135713.1, SRR1660805.17665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## undergoes RNA editing :: PMID: 10688364, 7992055 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGGC AGAAGAAAAT GGGGCAAAGC GTGCTCCGGG CGGTCTTCTT TTTAGTCCTG 
GGGCTTTTGG GTCATTCTCA CGGAGGATTC CCCAACACCA TCAGCATAGG TGGACTTTTC 
ATGAGAAACA CAGTGCAGGA GCACAGCGCT TTCCGCTTTG CCGTGCAGTT ATACAACACC 
AACCAGAACA CCACCGAGAA GCCCTTCCAT TTGAATTACC ACGTAGATCA CTTGGATTCC 
TCCAATAGTT TTTCCGTGAC AAATGCTTTC TGCTCCCAGT TCTCGAGAGG GGTGTATGCC 
ATCTTTGGAT TCTATGACCA GATGTCAATG AACACCCTGA CCTCCTTCTG TGGGGCCCTG 
CACACATCCT TTGTTACGCC TAGCTTCCCC ACTGACGCAG ATGTGCAGTT TGTCATCCAG 
ATGCGCCCAG CCTTGAAGGG CGCTATTCTG AGTCTTCTGG GTCATTACAA GTGGGAGAAG 
TTTGTGTACC TCTATGACAC AGAACGAGGA TTTTCCATCC TCCAAGCGAT TATGGAAGCA 
GCAGTGCAAA ACAACTGGCA AGTAACAGCA AGGTCTGTGG GAAACATAAA GGACGTCCAA 
GAATTCAGGC GCATCATTGA AGAAATGGAC AGGAGGCAGG AAAAGCGATA CTTGATTGAC 
TGCGAAGTCG AAAGGATTAA CACAATTTTG GAACAGGTTG TGATCCTAGG GAAACACTCA 
AGAGGTTATC ACTACATGCT CGCTAACCTG GGTTTTACTG ATATTTTACT GGAAAGAGTC 
ATGCATGGGG GAGCCAACAT TACAGGTTTC CAGATTGTCA ACAATGAAAA CCCTATGGTT 
CAGCAGTTCA TACAGCGCTG GGTGAGGCTG GATGAAAGGG AATTCCCTGA AGCCAAGAAT 
GCACCACTAA AGTATACATC TGCATTGACA CACGACGCAA TACTGGTCAT AGCAGAAGCT 
TTCCGCTACC TGAGGAGGCA GCGAGTAGAT GTGTCCCGGA GAGGAAGTGC TGGAGACTGC 
TTAGCAAATC CTGCTGTGCC CTGGAGTCAA GGAATTGATA TTGAGAGAGC TCTGAAAATG 
GTGCAAGTAC AAGGAATGAC TGGAAATATT CAATTTGACA CTTATGGACG TAGGACAAAT 
TATACCATCG ATGTGTATGA AATGAAAGTC AGTGGCTCTC GAAAAGCTGG CTACTGGAAT 
GAGTATGAAA GGTTTGTGCC TTTCTCAGAT CAGCAAATCA GCAATGACAG TGCATCCTCA 
GAGAATCGGA CCATAGTAGT GACTACCATT CTGGAATCAC CATATGTAAT GTACAAGAAG 
AACCATGAGC AACTGGAAGG AAATGAACGA TATGAAGGCT ATTGTGTAGA CCTAGCCTAT 
GAAATAGCCA AACATGTAAG GATCAAATAC AAATTGTCCA TCGTTGGTGA CGGGAAATAT 
GGTGCAAGGG ATCCAGAGAC TAAAATATGG AACGGCATGG TTGGGGAACT TGTCTATGGG 
AGAGCTGATA TAGCTGTTGC TCCACTCACT ATAACATTGG TCCGTGAAGA AGTCATAGAT 
TTTTCAAAGC CATTCATGAG CCTGGGCATC TCCATCATGA TAAAGAAGCC TCAGAAATCA 
AAACCAGGCG TATTCTCATT TCTGGATCCC CTGGCTTATG AAATCTGGAT GTGCATTGTC 
TTTGCTTACA TTGGAGTCAG CGTAGTTCTT TTCCTAGTCA GCAGGTTCAG TCCTTATGAA 
TGGCACTTGG AAGACAACAA TGAAGAACCT CGTGACCCAC AAAGTCCTCC TGATCCTCCA 
AATGAATTTG GAATATTTAA CAGTCTTTGG TTTTCCTTGG GTGCCTTTAT GCAGCAAGGA 
TGTGATATTT CTCCAAGATC ACTCTCCGGG CGCATTGTTG GAGGGGTTTG GTGGTTCTTC 
ACCCTGATCA TAATTTCTTC CTATACTGCC AATCTCGCTG CTTTCCTGAC TGTGGAGAGG 
ATGGTTTCTC CCATAGAGAG TGCTGAAGAC TTAGCTAAAC AGACTGAAAT TGCATATGGG 
ACCCTGGACT CCGGTTCAAC AAAAGAATTT TTCAGAAGAT CCAAAATTGC TGTGTACGAG 
AAAATGTGGT CTTACATGAA ATCAGCGGAG CCATCTGTGT TTACCAAAAC AACAGCAGAC 
GGAGTGGCCC GAGTGCGAAA GTCCAAGGGA AAGTTCGCCT TCCTGCTGGA GTCAACCATG 
AATGAGTACA TTGAGCAGAG AAAACCATGT GATACGATGA AAGTTGGTGG AAATCTGGAT 
TCCAAAGGCT ATGGTGTGGC AACCCCTAAA GGCTCAGCAT TAGGAAATGC TGTTAACCTG 
GCAGTATTAA AACTGAATGA GCAAGGCCTC TTGGACAAAT TGAAAAACAA ATGGTGGTAC 
GACAAAGGAG AGTGCGGCAG CGGGGGCGGT GACTCCAAGG ACAAGACCAG CGCTCTGAGC 
CTGAGCAATG TGGCAGGCGT TTTCTATATA CTTGTCGGAG GTCTGGGGCT GGCCATGATG 
GTGGCTTTGA TAGAATTCTG TTACAAATCA CGGGCAGAGT CCAAACGCAT GAAACTCACA 
AAGAACACCC AAAACTTTAA GCCTGCTCCT GCCACCAACA CTCAGAATTA TGCTACATAC 
AGAGAAGGCT ACAACGTGTA TGGAACAGAG AGTGTTAAGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000819.3
CDS	294..2978
Translation	MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI

Target ORF information:

RefSeq Version	NM_000828.4
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000828.4

ORF Insert Sequence:

ATGGCCAGGC AGAAGAAAAT GGGGCAAAGC GTGCTCCGGG CGGTCTTCTT TTTAGTCCTG 
GGGCTTTTGG GTCATTCTCA CGGAGGATTC CCCAACACCA TCAGCATAGG TGGACTTTTC 
ATGAGAAACA CAGTGCAGGA GCACAGCGCT TTCCGCTTTG CCGTGCAGTT ATACAACACC 
AACCAGAACA CCACCGAGAA GCCCTTCCAT TTGAATTACC ACGTAGATCA CTTGGATTCC 
TCCAATAGTT TTTCCGTGAC AAATGCTTTC TGCTCCCAGT TCTCGAGAGG GGTGTATGCC 
ATCTTTGGAT TCTATGACCA GATGTCAATG AACACCCTGA CCTCCTTCTG TGGGGCCCTG 
CACACATCCT TTGTTACGCC TAGCTTCCCC ACTGACGCAG ATGTGCAGTT TGTCATCCAG 
ATGCGCCCAG CCTTGAAGGG CGCTATTCTG AGTCTTCTGG GTCATTACAA GTGGGAGAAG 
TTTGTGTACC TCTATGACAC AGAACGAGGA TTTTCCATCC TCCAAGCGAT TATGGAAGCA 
GCAGTGCAAA ACAACTGGCA AGTAACAGCA AGGTCTGTGG GAAACATAAA GGACGTCCAA 
GAATTCAGGC GCATCATTGA AGAAATGGAC AGGAGGCAGG AAAAGCGATA CTTGATTGAC 
TGCGAAGTCG AAAGGATTAA CACAATTTTG GAACAGGTTG TGATCCTAGG GAAACACTCA 
AGAGGTTATC ACTACATGCT CGCTAACCTG GGTTTTACTG ATATTTTACT GGAAAGAGTC 
ATGCATGGGG GAGCCAACAT TACAGGTTTC CAGATTGTCA ACAATGAAAA CCCTATGGTT 
CAGCAGTTCA TACAGCGCTG GGTGAGGCTG GATGAAAGGG AATTCCCTGA AGCCAAGAAT 
GCACCACTAA AGTATACATC TGCATTGACA CACGACGCAA TACTGGTCAT AGCAGAAGCT 
TTCCGCTACC TGAGGAGGCA GCGAGTAGAT GTGTCCCGGA GAGGAAGTGC TGGAGACTGC 
TTAGCAAATC CTGCTGTGCC CTGGAGTCAA GGAATTGATA TTGAGAGAGC TCTGAAAATG 
GTGCAAGTAC AAGGAATGAC TGGAAATATT CAATTTGACA CTTATGGACG TAGGACAAAT 
TATACCATCG ATGTGTATGA AATGAAAGTC AGTGGCTCTC GAAAAGCTGG CTACTGGAAT 
GAGTATGAAA GGTTTGTGCC TTTCTCAGAT CAGCAAATCA GCAATGACAG TGCATCCTCA 
GAGAATCGGA CCATAGTAGT GACTACCATT CTGGAATCAC CATATGTAAT GTACAAGAAG 
AACCATGAGC AACTGGAAGG AAATGAACGA TATGAAGGCT ATTGTGTAGA CCTAGCCTAT 
GAAATAGCCA AACATGTAAG GATCAAATAC AAATTGTCCA TCGTTGGTGA CGGGAAATAT 
GGTGCAAGGG ATCCAGAGAC TAAAATATGG AACGGCATGG TTGGGGAACT TGTCTATGGG 
AGAGCTGATA TAGCTGTTGC TCCACTCACT ATAACATTGG TCCGTGAAGA AGTCATAGAT 
TTTTCAAAGC CATTCATGAG CCTGGGCATC TCCATCATGA TAAAGAAGCC TCAGAAATCA 
AAACCAGGCG TATTCTCATT TCTGGATCCC CTGGCTTATG AAATCTGGAT GTGCATTGTC 
TTTGCTTACA TTGGAGTCAG CGTAGTTCTT TTCCTAGTCA GCAGGTTCAG TCCTTATGAA 
TGGCACTTGG AAGACAACAA TGAAGAACCT CGTGACCCAC AAAGTCCTCC TGATCCTCCA 
AATGAATTTG GAATATTTAA CAGTCTTTGG TTTTCCTTGG GTGCCTTTAT GCAGCAAGGA 
TGTGATATTT CTCCAAGATC ACTCTCCGGG CGCATTGTTG GAGGGGTTTG GTGGTTCTTC 
ACCCTGATCA TAATTTCTTC CTATACTGCC AATCTCGCTG CTTTCCTGAC TGTGGAGAGG 
ATGGTTTCTC CCATAGAGAG TGCTGAAGAC TTAGCTAAAC AGACTGAAAT TGCATATGGG 
ACCCTGGACT CCGGTTCAAC AAAAGAATTT TTCAGAAGAT CCAAAATTGC TGTGTACGAG 
AAAATGTGGT CTTACATGAA ATCAGCGGAG CCATCTGTGT TTACCAAAAC AACAGCAGAC 
GGAGTGGCCC GAGTGCGAAA GTCCAAGGGA AAGTTCGCCT TCCTGCTGGA GTCAACCATG 
AATGAGTACA TTGAGCAGAG AAAACCATGT GATACGATGA AAGTTGGTGG AAATCTGGAT 
TCCAAAGGCT ATGGTGTGGC AACCCCTAAA GGCTCAGCAT TAGGAAATGC TGTTAACCTG 
GCAGTATTAA AACTGAATGA GCAAGGCCTC TTGGACAAAT TGAAAAACAA ATGGTGGTAC 
GACAAAGGAG AGTGCGGCAG CGGGGGCGGT GACTCCAAGG ACAAGACCAG CGCTCTGAGC 
CTGAGCAATG TGGCAGGCGT TTTCTATATA CTTGTCGGAG GTCTGGGGCT GGCCATGATG 
GTGGCTTTGA TAGAATTCTG TTACAAATCA CGGGCAGAGT CCAAACGCAT GAAACTCACA 
AAGAACACCC AAAACTTTAA GCCTGCTCCT GCCACCAACA CTCAGAATTA TGCTACATAC 
AGAGAAGGCT ACAACGTGTA TGGAACAGAG AGTGTTAAGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRIA3 ( NM_007325.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_015564.5 Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu108592
Clone ID Related Accession (Same CDS sequence)	NM_007325.5
Accession Version	NM_007325.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2685bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	glutamate receptor 3 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z83848.3, AL035426.2, Z82899.2, AL356213.10 and AL590139.11. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_007325.4. Transcript Variant: This variant (1) encodes isoform 1 (also known as flip isoform). RNA editing (AGA->GGA) changes Arg775Gly. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.37697.1, SRR1803612.141623.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000620443.2/ ENSP00000478489.1 RefSeq Select criteria :: based on conservation, expression, longest protein undergoes RNA editing :: PMID: 10688364, 7992055 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGGC AGAAGAAAAT GGGGCAAAGC GTGCTCCGGG CGGTCTTCTT TTTAGTCCTG 
GGGCTTTTGG GTCATTCTCA CGGAGGATTC CCCAACACCA TCAGCATAGG TGGACTTTTC 
ATGAGAAACA CAGTGCAGGA GCACAGCGCT TTCCGCTTTG CCGTGCAGTT ATACAACACC 
AACCAGAACA CCACCGAGAA GCCCTTCCAT TTGAATTACC ACGTAGATCA CTTGGATTCC 
TCCAATAGTT TTTCCGTGAC AAATGCTTTC TGCTCCCAGT TCTCGAGAGG GGTGTATGCC 
ATCTTTGGAT TCTATGACCA GATGTCAATG AACACCCTGA CCTCCTTCTG TGGGGCCCTG 
CACACATCCT TTGTTACGCC TAGCTTCCCC ACTGACGCAG ATGTGCAGTT TGTCATCCAG 
ATGCGCCCAG CCTTGAAGGG CGCTATTCTG AGTCTTCTGG GTCATTACAA GTGGGAGAAG 
TTTGTGTACC TCTATGACAC AGAACGAGGA TTTTCCATCC TCCAAGCGAT TATGGAAGCA 
GCAGTGCAAA ACAACTGGCA AGTAACAGCA AGGTCTGTGG GAAACATAAA GGACGTCCAA 
GAATTCAGGC GCATCATTGA AGAAATGGAC AGGAGGCAGG AAAAGCGATA CTTGATTGAC 
TGCGAAGTCG AAAGGATTAA CACAATTTTG GAACAGGTTG TGATCCTAGG GAAACACTCA 
AGAGGTTATC ACTACATGCT CGCTAACCTG GGTTTTACTG ATATTTTACT GGAAAGAGTC 
ATGCATGGGG GAGCCAACAT TACAGGTTTC CAGATTGTCA ACAATGAAAA CCCTATGGTT 
CAGCAGTTCA TACAGCGCTG GGTGAGGCTG GATGAAAGGG AATTCCCTGA AGCCAAGAAT 
GCACCACTAA AGTATACATC TGCATTGACA CACGACGCAA TACTGGTCAT AGCAGAAGCT 
TTCCGCTACC TGAGGAGGCA GCGAGTAGAT GTGTCCCGGA GAGGAAGTGC TGGAGACTGC 
TTAGCAAATC CTGCTGTGCC CTGGAGTCAA GGAATTGATA TTGAGAGAGC TCTGAAAATG 
GTGCAAGTAC AAGGAATGAC TGGAAATATT CAATTTGACA CTTATGGACG TAGGACAAAT 
TATACCATCG ATGTGTATGA AATGAAAGTC AGTGGCTCTC GAAAAGCTGG CTACTGGAAT 
GAGTATGAAA GGTTTGTGCC TTTCTCAGAT CAGCAAATCA GCAATGACAG TGCATCCTCA 
GAGAATCGGA CCATAGTAGT GACTACCATT CTGGAATCAC CATATGTAAT GTACAAGAAG 
AACCATGAGC AACTGGAAGG AAATGAACGA TATGAAGGCT ATTGTGTAGA CCTAGCCTAT 
GAAATAGCCA AACATGTAAG GATCAAATAC AAATTGTCCA TCGTTGGTGA CGGGAAATAT 
GGTGCAAGGG ATCCAGAGAC TAAAATATGG AACGGCATGG TTGGGGAACT TGTCTATGGG 
AGAGCTGATA TAGCTGTTGC TCCACTCACT ATAACATTGG TCCGTGAAGA AGTCATAGAT 
TTTTCAAAGC CATTCATGAG CCTGGGCATC TCCATCATGA TAAAGAAGCC TCAGAAATCA 
AAACCAGGCG TATTCTCATT TCTGGATCCC CTGGCTTATG AAATCTGGAT GTGCATTGTC 
TTTGCTTACA TTGGAGTCAG CGTAGTTCTT TTCCTAGTCA GCAGGTTCAG TCCTTATGAA 
TGGCACTTGG AAGACAACAA TGAAGAACCT CGTGACCCAC AAAGTCCTCC TGATCCTCCA 
AATGAATTTG GAATATTTAA CAGTCTTTGG TTTTCCTTGG GTGCCTTTAT GCAGCAAGGA 
TGTGATATTT CTCCAAGATC ACTCTCCGGG CGCATTGTTG GAGGGGTTTG GTGGTTCTTC 
ACCCTGATCA TAATTTCTTC CTATACTGCC AATCTCGCTG CTTTCCTGAC TGTGGAGAGG 
ATGGTTTCTC CCATAGAGAG TGCTGAAGAC TTAGCTAAAC AGACTGAAAT TGCATATGGG 
ACCCTGGACT CCGGTTCAAC AAAAGAATTT TTCAGAAGAT CCAAAATTGC TGTGTACGAG 
AAAATGTGGT CTTACATGAA ATCAGCGGAG CCATCTGTGT TTACCAAAAC AACAGCAGAC 
GGAGTGGCCC GAGTGCGAAA GTCCAAGGGA AAGTTCGCCT TCCTGCTGGA GTCAACCATG 
AATGAGTACA TTGAGCAGAG AAAACCATGT GATACGATGA AAGTTGGTGG AAATCTGGAT 
TCCAAAGGCT ATGGTGTGGC AACCCCTAAA GGCTCAGCAT TAAGAACGCC TGTAAACCTT 
GCAGTATTGA AACTCAGTGA ACAAGGCATC TTAGACAAGC TGAAAAACAA ATGGTGGTAC 
GATAAGGGGG AATGTGGAGC CAAGGACTCC GGGAGTAAGG ACAAGACCAG CGCTCTGAGC 
CTGAGCAATG TGGCAGGCGT TTTCTATATA CTTGTCGGAG GTCTGGGGCT GGCCATGATG 
GTGGCTTTGA TAGAATTCTG TTACAAATCA CGGGCAGAGT CCAAACGCAT GAAACTCACA 
AAGAACACCC AAAACTTTAA GCCTGCTCCT GCCACCAACA CTCAGAATTA TGCTACATAC 
AGAGAAGGCT ACAACGTGTA TGGAACAGAG AGTGTTAAGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_015564.5
CDS	259..2943
Translation	MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI

Target ORF information:

RefSeq Version	NM_007325.5
Organism	Homo sapiens(human)
Definition	Homo sapiens glutamate ionotropic receptor AMPA type subunit 3 (GRIA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007325.5

ORF Insert Sequence:

ATGGCCAGGC AGAAGAAAAT GGGGCAAAGC GTGCTCCGGG CGGTCTTCTT TTTAGTCCTG 
GGGCTTTTGG GTCATTCTCA CGGAGGATTC CCCAACACCA TCAGCATAGG TGGACTTTTC 
ATGAGAAACA CAGTGCAGGA GCACAGCGCT TTCCGCTTTG CCGTGCAGTT ATACAACACC 
AACCAGAACA CCACCGAGAA GCCCTTCCAT TTGAATTACC ACGTAGATCA CTTGGATTCC 
TCCAATAGTT TTTCCGTGAC AAATGCTTTC TGCTCCCAGT TCTCGAGAGG GGTGTATGCC 
ATCTTTGGAT TCTATGACCA GATGTCAATG AACACCCTGA CCTCCTTCTG TGGGGCCCTG 
CACACATCCT TTGTTACGCC TAGCTTCCCC ACTGACGCAG ATGTGCAGTT TGTCATCCAG 
ATGCGCCCAG CCTTGAAGGG CGCTATTCTG AGTCTTCTGG GTCATTACAA GTGGGAGAAG 
TTTGTGTACC TCTATGACAC AGAACGAGGA TTTTCCATCC TCCAAGCGAT TATGGAAGCA 
GCAGTGCAAA ACAACTGGCA AGTAACAGCA AGGTCTGTGG GAAACATAAA GGACGTCCAA 
GAATTCAGGC GCATCATTGA AGAAATGGAC AGGAGGCAGG AAAAGCGATA CTTGATTGAC 
TGCGAAGTCG AAAGGATTAA CACAATTTTG GAACAGGTTG TGATCCTAGG GAAACACTCA 
AGAGGTTATC ACTACATGCT CGCTAACCTG GGTTTTACTG ATATTTTACT GGAAAGAGTC 
ATGCATGGGG GAGCCAACAT TACAGGTTTC CAGATTGTCA ACAATGAAAA CCCTATGGTT 
CAGCAGTTCA TACAGCGCTG GGTGAGGCTG GATGAAAGGG AATTCCCTGA AGCCAAGAAT 
GCACCACTAA AGTATACATC TGCATTGACA CACGACGCAA TACTGGTCAT AGCAGAAGCT 
TTCCGCTACC TGAGGAGGCA GCGAGTAGAT GTGTCCCGGA GAGGAAGTGC TGGAGACTGC 
TTAGCAAATC CTGCTGTGCC CTGGAGTCAA GGAATTGATA TTGAGAGAGC TCTGAAAATG 
GTGCAAGTAC AAGGAATGAC TGGAAATATT CAATTTGACA CTTATGGACG TAGGACAAAT 
TATACCATCG ATGTGTATGA AATGAAAGTC AGTGGCTCTC GAAAAGCTGG CTACTGGAAT 
GAGTATGAAA GGTTTGTGCC TTTCTCAGAT CAGCAAATCA GCAATGACAG TGCATCCTCA 
GAGAATCGGA CCATAGTAGT GACTACCATT CTGGAATCAC CATATGTAAT GTACAAGAAG 
AACCATGAGC AACTGGAAGG AAATGAACGA TATGAAGGCT ATTGTGTAGA CCTAGCCTAT 
GAAATAGCCA AACATGTAAG GATCAAATAC AAATTGTCCA TCGTTGGTGA CGGGAAATAT 
GGTGCAAGGG ATCCAGAGAC TAAAATATGG AACGGCATGG TTGGGGAACT TGTCTATGGG 
AGAGCTGATA TAGCTGTTGC TCCACTCACT ATAACATTGG TCCGTGAAGA AGTCATAGAT 
TTTTCAAAGC CATTCATGAG CCTGGGCATC TCCATCATGA TAAAGAAGCC TCAGAAATCA 
AAACCAGGCG TATTCTCATT TCTGGATCCC CTGGCTTATG AAATCTGGAT GTGCATTGTC 
TTTGCTTACA TTGGAGTCAG CGTAGTTCTT TTCCTAGTCA GCAGGTTCAG TCCTTATGAA 
TGGCACTTGG AAGACAACAA TGAAGAACCT CGTGACCCAC AAAGTCCTCC TGATCCTCCA 
AATGAATTTG GAATATTTAA CAGTCTTTGG TTTTCCTTGG GTGCCTTTAT GCAGCAAGGA 
TGTGATATTT CTCCAAGATC ACTCTCCGGG CGCATTGTTG GAGGGGTTTG GTGGTTCTTC 
ACCCTGATCA TAATTTCTTC CTATACTGCC AATCTCGCTG CTTTCCTGAC TGTGGAGAGG 
ATGGTTTCTC CCATAGAGAG TGCTGAAGAC TTAGCTAAAC AGACTGAAAT TGCATATGGG 
ACCCTGGACT CCGGTTCAAC AAAAGAATTT TTCAGAAGAT CCAAAATTGC TGTGTACGAG 
AAAATGTGGT CTTACATGAA ATCAGCGGAG CCATCTGTGT TTACCAAAAC AACAGCAGAC 
GGAGTGGCCC GAGTGCGAAA GTCCAAGGGA AAGTTCGCCT TCCTGCTGGA GTCAACCATG 
AATGAGTACA TTGAGCAGAG AAAACCATGT GATACGATGA AAGTTGGTGG AAATCTGGAT 
TCCAAAGGCT ATGGTGTGGC AACCCCTAAA GGCTCAGCAT TAAGAACGCC TGTAAACCTT 
GCAGTATTGA AACTCAGTGA ACAAGGCATC TTAGACAAGC TGAAAAACAA ATGGTGGTAC 
GATAAGGGGG AATGTGGAGC CAAGGACTCC GGGAGTAAGG ACAAGACCAG CGCTCTGAGC 
CTGAGCAATG TGGCAGGCGT TTTCTATATA CTTGTCGGAG GTCTGGGGCT GGCCATGATG 
GTGGCTTTGA TAGAATTCTG TTACAAATCA CGGGCAGAGT CCAAACGCAT GAAACTCACA 
AAGAACACCC AAAACTTTAA GCCTGCTCCT GCCACCAACA CTCAGAATTA TGCTACATAC 
AGAGAAGGCT ACAACGTGTA TGGAACAGAG AGTGTTAAGA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic variation of GRIA3 gene is associated with vulnerability to methamphetamine dependence and its associated psychosis.
Journal of psychopharmacology (Oxford, England)269881117750153(2018 Jan)
Iamjan SA,Thanoi S,Watiktinkorn P,Reynolds GP,Nudmamud-Thanoi S

A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.
Human molecular genetics26(20)3869-3882(2017 Oct)
Davies B,Brown LA,Cais O,Watson J,Clayton AJ,Chang VT,Biggs D,Preece C,Hernandez-Pliego P,Krohn J,Bhomra A,Twigg SRF,Rimmer A,Kanapin A,,Sen A,Zaiwalla Z,McVean G,Foster R,Donnelly P,Taylor JC,Blair E,Nutt D,Aricescu AR,Greger IH,Peirson SN,Flint J,Martin HC

Anti-AMPA GluA3 antibodies in Frontotemporal dementia: a new molecular target.
Scientific reports7(1)6723(2017 Jul)
Borroni B,Stanic J,Verpelli C,Mellone M,Bonomi E,Alberici A,Bernasconi P,Culotta L,Zianni E,Archetti S,Manes M,Gazzina S,Ghidoni R,Benussi L,Stuani C,Di Luca M,Sala C,Buratti E,Padovani A,Gardoni F

MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway.
Journal of hematology & oncology10(1)125(2017 Jun)
Wei CH,Wu G,Cai Q,Gao XC,Tong F,Zhou R,Zhang RG,Dong JH,Hu Y,Dong XR

AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women.
Journal of neuroimmunology30551-58(2017 Apr)
Bhandage AK,Jin Z,Hellgren C,Korol SV,Nowak K,Williamsson L,Sundstr?m-Poromaa I,Birnir B

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GRIA3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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