GPX2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPX2
Entrez Gene ID	2877
Full Name	glutathione peroxidase 2
Synonyms	GI-GPx,GPRP,GPRP-2,GPx-2,GPx-GI,GSHPX-GI,GSHPx-2
General protein information	Preferred Names glutathione peroxidase 2 Names glutathione peroxidase 2 gastrointestinal glutathione peroxidase glutathione peroxidase 2 (gastrointestinal) glutathione peroxidase-related protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q23.3
Summary	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016].
Disorder MIM:	138319

mRNA and Protein(s)

mRNA	Protein	Name
NM_002083.3	NP_002074.2	glutathione peroxidase 2
NM_002083.4	NP_002074.2	glutathione peroxidase 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gpx2	NP_899653.2
Homo sapiens (human)	GPX2	NP_002074.2
Gallus gallus (chicken)	GPX2	NP_001264783.1
Bos taurus (cattle)	GPX2	NP_001156611.1
Xenopus tropicalis (tropical clawed frog)	gpx2	NP_001243244.1
Mus musculus (house mouse)	Gpx2	NP_109602.2
Pan troglodytes (chimpanzee)	GPX2	NP_001108606.1
	GPX2	NP_001108609.1
Canis lupus familiaris (dog)	GPX2	NP_001108607.1

Gene Ontology
Bibliography

Related articles in PubMed

YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation.
Huang H, Zhang W, Pan Y, Gao Y, Deng L, Li F, Li F, Ma X, Hou S, Xu J, Li P, Li X, Hu G, Li C, Chen H, Zhang L, Ji H
Cancer research77(21)5769-5781(2017 Nov)

Clinicopathological and prognostic significance of GPx2 protein expression in nasopharyngeal carcinoma.
Liu C, He X, Wu X, Wang Z, Zuo W, Hu G
Cancer biomarkers : section A of Disease markers19(3)335-340(2017 Jul)

GPX2 overexpression indicates poor prognosis in patients with hepatocellular carcinoma.
Liu T, Kan XF, Ma C, Chen LL, Cheng TT, Zou ZW, Li Y, Cao FJ, Zhang WJ, Yao J, Li PD
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(6)1010428317700410(2017 Jun)

Prognostic significance of glutathione peroxidase 2 in gastric carcinoma.
Liu D, Sun L, Tong J, Chen X, Li H, Zhang Q
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(6)1010428317701443(2017 Jun)

Clinicopathological and prognostic significance of GPX2 protein expression in esophageal squamous cell carcinoma.
Lei Z, Tian D, Zhang C, Zhao S, Su M
BMC cancer16410(2016 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Yes associated protein 1 (YAP) activation led to excessive accumulation of reactive oxygen species (ROS) by downregulating the antioxidant enzyme glutathione peroxidase GPX2 in a manner related to tumor protein p63 blockade.
Title: YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation.

glutathione peroxidase 2 overexpression contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients.
Title: GPX2 overexpression indicates poor prognosis in patients with hepatocellular carcinoma.

Glutathione peroxidase 2 expression is a novel independent prognostic biomarker for gastric carcinoma that may be used to devise personalized therapeutic regimens and precision treatments for this disease
Title: Prognostic significance of glutathione peroxidase 2 in gastric carcinoma.

Results showed that the expression of GPX2 was significantly up-regulated within esophageal squamous cell carcinoma tissues.
Title: Clinicopathological and prognostic significance of GPX2 protein expression in esophageal squamous cell carcinoma.

Cardamonin exposure and selenium availability regulate expression of HO-1, GPX2 and TrxR1 in human intestinal cells.
Title: Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2-regulated antioxidant enzymes in intestinal Caco-2 cells.

The following GPX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55924	NM_002083.4 Latest version!	Homo sapiens glutathione peroxidase 2 (GPX2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu55924	NM_002083.3	Homo sapiens glutathione peroxidase 2 (GPX2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPX2 ( NM_002083.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002074.2 Homo sapiens glutathione peroxidase 2 (GPX2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu55924
Clone ID Related Accession (Same CDS sequence)	NM_002083.3 , NM_002083.4
Accession Version	NM_002083.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	glutathione peroxidase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG429974.1 and BC022820.1. On Feb 10, 2012 this sequence version replaced NM_002083.2. Transcript Variant: This variant (1) represents the protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279839.10372.1, ERR279848.4854.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 2388849 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTTTCA TTGCCAAGTC CTTCTATGAC CTCAGTGCCA TCAGCCTGGA TGGGGAGAAG 
GTAGATTTCA ATACGTTCCG GGGCAGGGCC GTGCTGATTG AGAATGTGGC TTCGCTCTGA 
GGCACAACCA CCCGGGACTT CACCCAGCTC AACGAGCTGC AATGCCGCTT TCCCAGGCGC 
CTGGTGGTCC TTGGCTTCCC TTGCAACCAA TTTGGACATC AGGAGAACTG TCAGAATGAG 
GAGATCCTGA ACAGTCTCAA GTATGTCCGT CCTGGGGGTG GATACCAGCC CACCTTCACC 
CTTGTCCAAA AATGTGAGGT GAATGGGCAG AACGAGCATC CTGTCTTCGC CTACCTGAAG 
GACAAGCTCC CCTACCCTTA TGATGACCCA TTTTCCCTCA TGACCGATCC CAAGCTCATC 
ATTTGGAGCC CTGTGCGCCG CTCAGATGTG GCCTGGAACT TTGAGAAGTT CCTCATAGGG 
CCGGAGGGAG AGCCCTTCCG ACGCTACAGC CGCACCTTCC CAACCATCAA CATTGAGCCT 
GACATCAAGC GCCTCCTTAA AGTTGCCATA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002074.2
CDS	180..752
Translation	MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASL*GTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI

Target ORF information:

RefSeq Version	NM_002083.3
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione peroxidase 2 (GPX2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002083.3

ORF Insert Sequence:

ATGGCTTTCA TTGCCAAGTC CTTCTATGAC CTCAGTGCCA TCAGCCTGGA TGGGGAGAAG 
GTAGATTTCA ATACGTTCCG GGGCAGGGCC GTGCTGATTG AGAATGTGGC TTCGCTCTGA 
GGCACAACCA CCCGGGACTT CACCCAGCTC AACGAGCTGC AATGCCGCTT TCCCAGGCGC 
CTGGTGGTCC TTGGCTTCCC TTGCAACCAA TTTGGACATC AGGAGAACTG TCAGAATGAG 
GAGATCCTGA ACAGTCTCAA GTATGTCCGT CCTGGGGGTG GATACCAGCC CACCTTCACC 
CTTGTCCAAA AATGTGAGGT GAATGGGCAG AACGAGCATC CTGTCTTCGC CTACCTGAAG 
GACAAGCTCC CCTACCCTTA TGATGACCCA TTTTCCCTCA TGACCGATCC CAAGCTCATC 
ATTTGGAGCC CTGTGCGCCG CTCAGATGTG GCCTGGAACT TTGAGAAGTT CCTCATAGGG 
CCGGAGGGAG AGCCCTTCCG ACGCTACAGC CGCACCTTCC CAACCATCAA CATTGAGCCT 
GACATCAAGC GCCTCCTTAA AGTTGCCATA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPX2 ( NM_002083.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002074.2 Homo sapiens glutathione peroxidase 2 (GPX2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu55924
Clone ID Related Accession (Same CDS sequence)	NM_002083.3 , NM_002083.4
Accession Version	NM_002083.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	glutathione peroxidase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG429974.1 and BC022820.1. On Nov 22, 2018 this sequence version replaced NM_002083.3. Transcript Variant: This variant (1) represents the protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005277.1, X53463.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000389614.6/ ENSP00000374265.5 protein contains selenocysteine :: PMID: 2388849 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTTCA TTGCCAAGTC CTTCTATGAC CTCAGTGCCA TCAGCCTGGA TGGGGAGAAG 
GTAGATTTCA ATACGTTCCG GGGCAGGGCC GTGCTGATTG AGAATGTGGC TTCGCTCTGA 
GGCACAACCA CCCGGGACTT CACCCAGCTC AACGAGCTGC AATGCCGCTT TCCCAGGCGC 
CTGGTGGTCC TTGGCTTCCC TTGCAACCAA TTTGGACATC AGGAGAACTG TCAGAATGAG 
GAGATCCTGA ACAGTCTCAA GTATGTCCGT CCTGGGGGTG GATACCAGCC CACCTTCACC 
CTTGTCCAAA AATGTGAGGT GAATGGGCAG AACGAGCATC CTGTCTTCGC CTACCTGAAG 
GACAAGCTCC CCTACCCTTA TGATGACCCA TTTTCCCTCA TGACCGATCC CAAGCTCATC 
ATTTGGAGCC CTGTGCGCCG CTCAGATGTG GCCTGGAACT TTGAGAAGTT CCTCATAGGG 
CCGGAGGGAG AGCCCTTCCG ACGCTACAGC CGCACCTTCC CAACCATCAA CATTGAGCCT 
GACATCAAGC GCCTCCTTAA AGTTGCCATA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002074.2
CDS	20..592
Translation	MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASL*GTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI

Target ORF information:

RefSeq Version	NM_002083.4
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione peroxidase 2 (GPX2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002083.4

ORF Insert Sequence:

ATGGCTTTCA TTGCCAAGTC CTTCTATGAC CTCAGTGCCA TCAGCCTGGA TGGGGAGAAG 
GTAGATTTCA ATACGTTCCG GGGCAGGGCC GTGCTGATTG AGAATGTGGC TTCGCTCTGA 
GGCACAACCA CCCGGGACTT CACCCAGCTC AACGAGCTGC AATGCCGCTT TCCCAGGCGC 
CTGGTGGTCC TTGGCTTCCC TTGCAACCAA TTTGGACATC AGGAGAACTG TCAGAATGAG 
GAGATCCTGA ACAGTCTCAA GTATGTCCGT CCTGGGGGTG GATACCAGCC CACCTTCACC 
CTTGTCCAAA AATGTGAGGT GAATGGGCAG AACGAGCATC CTGTCTTCGC CTACCTGAAG 
GACAAGCTCC CCTACCCTTA TGATGACCCA TTTTCCCTCA TGACCGATCC CAAGCTCATC 
ATTTGGAGCC CTGTGCGCCG CTCAGATGTG GCCTGGAACT TTGAGAAGTT CCTCATAGGG 
CCGGAGGGAG AGCCCTTCCG ACGCTACAGC CGCACCTTCC CAACCATCAA CATTGAGCCT 
GACATCAAGC GCCTCCTTAA AGTTGCCATA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation.
Cancer research77(21)5769-5781(2017 Nov)
Huang H,Zhang W,Pan Y,Gao Y,Deng L,Li F,Li F,Ma X,Hou S,Xu J,Li P,Li X,Hu G,Li C,Chen H,Zhang L,Ji H

Clinicopathological and prognostic significance of GPx2 protein expression in nasopharyngeal carcinoma.
Cancer biomarkers : section A of Disease markers19(3)335-340(2017 Jul)
Liu C,He X,Wu X,Wang Z,Zuo W,Hu G

GPX2 overexpression indicates poor prognosis in patients with hepatocellular carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(6)1010428317700410(2017 Jun)
Liu T,Kan XF,Ma C,Chen LL,Cheng TT,Zou ZW,Li Y,Cao FJ,Zhang WJ,Yao J,Li PD

Prognostic significance of glutathione peroxidase 2 in gastric carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(6)1010428317701443(2017 Jun)
Liu D,Sun L,Tong J,Chen X,Li H,Zhang Q

Clinicopathological and prognostic significance of GPX2 protein expression in esophageal squamous cell carcinoma.
BMC cancer16410(2016 07)
Lei Z,Tian D,Zhang C,Zhao S,Su M

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GPX2 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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