GPS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPS2
Entrez Gene ID	2874
Full Name	G protein pathway suppressor 2
Synonyms	AMF-1
General protein information	Preferred Names G protein pathway suppressor 2 Names G protein pathway suppressor 2 GPS-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.1
Summary	This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008].
Disorder MIM:	601935

mRNA and Protein(s)

mRNA	Protein	Name
NM_004489.5	NP_004480.1	G protein pathway suppressor 2
NM_004489.4	NP_004480.1	G protein pathway suppressor 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GPS2	XP_511971.3
Canis lupus familiaris (dog)	GPS2	XP_003639092.1
Homo sapiens (human)	GPS2	NP_004480.1
	LOC721816	XP_002800321.1
Bos taurus (cattle)	GPS2	NP_001069242.1
Mus musculus (house mouse)	Gps2	NP_062700.2
Danio rerio (zebrafish)	gps2	NP_957267.1
Xenopus tropicalis (tropical clawed frog)	gps2	NP_001107718.1
Rattus norvegicus (Norway rat)	Gps2	NP_001017477.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma.
Huang XD, Xiao FJ, Wang SX, Yin RH, Lu CR, Li QF, Liu N, Zhang Y, Wang LS, Li PY
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(10)13333-13343(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our studies identify GPS2 functions as a tumor suppressor in LPS and its downregulation is correlated to prognosis of LPS.
Title: G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma.

The study of adipose tissue from humans with and without obesity revealed correlations between reduced GPS2 expression in macrophages, elevated systemic and adipose tissue inflammation, and diabetic status.
Title: Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.

regulation of GPS2 by posttranslational modifications provides an effective strategy for modulating its molecular function within the nuclear compartment.
Title: Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation.

Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 and GPS2 genes, resulting in fusion gene MLL4-GPS2, the expression of which promotes independent growth.
Title: Identification of an MLL4-GPS2 fusion as an oncogenic driver of undifferentiated spindle cell sarcoma in a child.

Posttranslational modification of GPS2 by SUMOylation may serve as a key factor that regulates the function of GPS2 in vivo.
Title: SUMOylation of GPS2 protein regulates its transcription-suppressing function.

The following GPS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04401	NM_004489.5 Latest version!	Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu04401	NM_004489.4	Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPS2 ( NM_004489.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004480.1 Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA.

Price & Availability↑

CloneID	OHu04401
Clone ID Related Accession (Same CDS sequence)	NM_004489.5 , NM_004489.4
Accession Version	NM_004489.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	G protein pathway suppressor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC026954.14 and BC013652.1. On Nov 23, 2018 this sequence version replaced NM_004489.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.68963.1, SRR1803612.98914.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380728.7/ ENSP00000370104.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCGCAC TCCTGGAGCG CCCCAAGCTT TCCAACGCCA TGGCCAGGGC GCTGCACCGG 
CACATTATGA TGGAGCGGGA GCGCAAGCGG CAGGAGGAAG AAGAGGTGGA TAAGATGATG 
GAACAGAAGA TGAAGGAAGA ACAGGAGAGA AGGAAGAAAA AGGAGATGGA AGAGAGAATG 
TCATTAGAGG AGACCAAGGA ACAAATTCTG AAGTTGGAGG AGAAGCTTTT GGCTCTACAG 
GAAGAGAAGC ACCAGCTTTT CCTGCAGCTC AAGAAAGTTT TACATGAGGA AGAAAAACGG 
AGGCGAAAGG AACAGAGTGA CCTGACCACC CTAACATCAG CTGCATACCA GCAGAGCCTG 
ACTGTTCACA CAGGAACTCA TCTCCTCAGC ATGCAGGGGA GCCCTGGAGG ACACAATCGC 
CCAGGCACCC TCATGGCAGC TGACAGAGCC AAACAAATGT TTGGACCCCA AGTGCTTACG 
ACCCGGCACT ACGTGGGCTC AGCAGCTGCT TTTGCAGGGA CACCAGAGCA TGGACAATTC 
CAAGGCAGTC CTGGTGGTGC CTATGGGACT GCTCAGCCCC CACCTCACTA TGGGCCCACA 
CAGCCAGCTT ATAGTCCTAG TCAGCAGCTC AGAGCTCCTT CGGCATTCCC TGCAGTGCAG 
TACCTATCTC AGCCACAGCC ACAGCCCTAT GCTGTGCATG GCCACTTTCA GCCCACTCAG 
ACAGGTTTCC TCCAGCCTGG TGGTGCCCTG TCCTTGCAAA AGCAGATGGA ACATGCTAAC 
CAGCAGACTG GCTTCTCCGA CTCATCCTCT CTGCGCCCCA TGCACCCCCA GGCTCTGCAT 
CCAGCCCCTG GACTCCTTGC TTCCCCCCAG CTCCCTGTGC AGATGCAGCC AGCAGGAAAG 
TCGGGCTTTG CAGCTACCAG CCAACCTGGC CCTCGGCTCC CCTTCATCCA ACACAGCCAG 
AACCCGCGAT TCTACCACAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004480.1
CDS	98..1081
Translation	MPALLERPKLSNAMARALHRHIMMERERKRQEEEEVDKMMEQKMKEEQERRKKKEMEERMSLEETKEQILKLEEKLLALQEEKHQLFLQLKKVLHEEEKRRRKEQSDLTTLTSAAYQQSLTVHTGTHLLSMQGSPGGHNRPGTLMAADRAKQMFGPQVLTTRHYVGSAAAFAGTPEHGQFQGSPGGAYGTAQPPPHYGPTQPAYSPSQQLRAPSAFPAVQYLSQPQPQPYAVHGHFQPTQTGFLQPGGALSLQKQMEHANQQTGFSDSSSLRPMHPQALHPAPGLLASPQLPVQMQPAGKSGFAATSQPGPRLPFIQHSQNPRFYHK

Target ORF information:

RefSeq Version	NM_004489.5
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004489.5

ORF Insert Sequence:

ATGCCCGCAC TCCTGGAGCG CCCCAAGCTT TCCAACGCCA TGGCCAGGGC GCTGCACCGG 
CACATTATGA TGGAGCGGGA GCGCAAGCGG CAGGAGGAAG AAGAGGTGGA TAAGATGATG 
GAACAGAAGA TGAAGGAAGA ACAGGAGAGA AGGAAGAAAA AGGAGATGGA AGAGAGAATG 
TCATTAGAGG AGACCAAGGA ACAAATTCTG AAGTTGGAGG AGAAGCTTTT GGCTCTACAG 
GAAGAGAAGC ACCAGCTTTT CCTGCAGCTC AAGAAAGTTT TACATGAGGA AGAAAAACGG 
AGGCGAAAGG AACAGAGTGA CCTGACCACC CTAACATCAG CTGCATACCA GCAGAGCCTG 
ACTGTTCACA CAGGAACTCA TCTCCTCAGC ATGCAGGGGA GCCCTGGAGG ACACAATCGC 
CCAGGCACCC TCATGGCAGC TGACAGAGCC AAACAAATGT TTGGACCCCA AGTGCTTACG 
ACCCGGCACT ACGTGGGCTC AGCAGCTGCT TTTGCAGGGA CACCAGAGCA TGGACAATTC 
CAAGGCAGTC CTGGTGGTGC CTATGGGACT GCTCAGCCCC CACCTCACTA TGGGCCCACA 
CAGCCAGCTT ATAGTCCTAG TCAGCAGCTC AGAGCTCCTT CGGCATTCCC TGCAGTGCAG 
TACCTATCTC AGCCACAGCC ACAGCCCTAT GCTGTGCATG GCCACTTTCA GCCCACTCAG 
ACAGGTTTCC TCCAGCCTGG TGGTGCCCTG TCCTTGCAAA AGCAGATGGA ACATGCTAAC 
CAGCAGACTG GCTTCTCCGA CTCATCCTCT CTGCGCCCCA TGCACCCCCA GGCTCTGCAT 
CCAGCCCCTG GACTCCTTGC TTCCCCCCAG CTCCCTGTGC AGATGCAGCC AGCAGGAAAG 
TCGGGCTTTG CAGCTACCAG CCAACCTGGC CCTCGGCTCC CCTTCATCCA ACACAGCCAG 
AACCCGCGAT TCTACCACAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPS2 ( NM_004489.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004480.1 Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA.

Price & Availability↑

CloneID	OHu04401
Clone ID Related Accession (Same CDS sequence)	NM_004489.5 , NM_004489.4
Accession Version	NM_004489.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	G protein pathway suppressor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC013652.1 and BC014192.2. On or before Oct 6, 2004 this sequence version replaced NM_032938.1, NM_004489.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013652.1, BC107738.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCGCAC TCCTGGAGCG CCCCAAGCTT TCCAACGCCA TGGCCAGGGC GCTGCACCGG 
CACATTATGA TGGAGCGGGA GCGCAAGCGG CAGGAGGAAG AAGAGGTGGA TAAGATGATG 
GAACAGAAGA TGAAGGAAGA ACAGGAGAGA AGGAAGAAAA AGGAGATGGA AGAGAGAATG 
TCATTAGAGG AGACCAAGGA ACAAATTCTG AAGTTGGAGG AGAAGCTTTT GGCTCTACAG 
GAAGAGAAGC ACCAGCTTTT CCTGCAGCTC AAGAAAGTTT TACATGAGGA AGAAAAACGG 
AGGCGAAAGG AACAGAGTGA CCTGACCACC CTAACATCAG CTGCATACCA GCAGAGCCTG 
ACTGTTCACA CAGGAACTCA TCTCCTCAGC ATGCAGGGGA GCCCTGGAGG ACACAATCGC 
CCAGGCACCC TCATGGCAGC TGACAGAGCC AAACAAATGT TTGGACCCCA AGTGCTTACG 
ACCCGGCACT ACGTGGGCTC AGCAGCTGCT TTTGCAGGGA CACCAGAGCA TGGACAATTC 
CAAGGCAGTC CTGGTGGTGC CTATGGGACT GCTCAGCCCC CACCTCACTA TGGGCCCACA 
CAGCCAGCTT ATAGTCCTAG TCAGCAGCTC AGAGCTCCTT CGGCATTCCC TGCAGTGCAG 
TACCTATCTC AGCCACAGCC ACAGCCCTAT GCTGTGCATG GCCACTTTCA GCCCACTCAG 
ACAGGTTTCC TCCAGCCTGG TGGTGCCCTG TCCTTGCAAA AGCAGATGGA ACATGCTAAC 
CAGCAGACTG GCTTCTCCGA CTCATCCTCT CTGCGCCCCA TGCACCCCCA GGCTCTGCAT 
CCAGCCCCTG GACTCCTTGC TTCCCCCCAG CTCCCTGTGC AGATGCAGCC AGCAGGAAAG 
TCGGGCTTTG CAGCTACCAG CCAACCTGGC CCTCGGCTCC CCTTCATCCA ACACAGCCAG 
AACCCGCGAT TCTACCACAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004480.1
CDS	77..1060
Translation	MPALLERPKLSNAMARALHRHIMMERERKRQEEEEVDKMMEQKMKEEQERRKKKEMEERMSLEETKEQILKLEEKLLALQEEKHQLFLQLKKVLHEEEKRRRKEQSDLTTLTSAAYQQSLTVHTGTHLLSMQGSPGGHNRPGTLMAADRAKQMFGPQVLTTRHYVGSAAAFAGTPEHGQFQGSPGGAYGTAQPPPHYGPTQPAYSPSQQLRAPSAFPAVQYLSQPQPQPYAVHGHFQPTQTGFLQPGGALSLQKQMEHANQQTGFSDSSSLRPMHPQALHPAPGLLASPQLPVQMQPAGKSGFAATSQPGPRLPFIQHSQNPRFYHK

Target ORF information:

RefSeq Version	NM_004489.4
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein pathway suppressor 2 (GPS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004489.4

ORF Insert Sequence:

ATGCCCGCAC TCCTGGAGCG CCCCAAGCTT TCCAACGCCA TGGCCAGGGC GCTGCACCGG 
CACATTATGA TGGAGCGGGA GCGCAAGCGG CAGGAGGAAG AAGAGGTGGA TAAGATGATG 
GAACAGAAGA TGAAGGAAGA ACAGGAGAGA AGGAAGAAAA AGGAGATGGA AGAGAGAATG 
TCATTAGAGG AGACCAAGGA ACAAATTCTG AAGTTGGAGG AGAAGCTTTT GGCTCTACAG 
GAAGAGAAGC ACCAGCTTTT CCTGCAGCTC AAGAAAGTTT TACATGAGGA AGAAAAACGG 
AGGCGAAAGG AACAGAGTGA CCTGACCACC CTAACATCAG CTGCATACCA GCAGAGCCTG 
ACTGTTCACA CAGGAACTCA TCTCCTCAGC ATGCAGGGGA GCCCTGGAGG ACACAATCGC 
CCAGGCACCC TCATGGCAGC TGACAGAGCC AAACAAATGT TTGGACCCCA AGTGCTTACG 
ACCCGGCACT ACGTGGGCTC AGCAGCTGCT TTTGCAGGGA CACCAGAGCA TGGACAATTC 
CAAGGCAGTC CTGGTGGTGC CTATGGGACT GCTCAGCCCC CACCTCACTA TGGGCCCACA 
CAGCCAGCTT ATAGTCCTAG TCAGCAGCTC AGAGCTCCTT CGGCATTCCC TGCAGTGCAG 
TACCTATCTC AGCCACAGCC ACAGCCCTAT GCTGTGCATG GCCACTTTCA GCCCACTCAG 
ACAGGTTTCC TCCAGCCTGG TGGTGCCCTG TCCTTGCAAA AGCAGATGGA ACATGCTAAC 
CAGCAGACTG GCTTCTCCGA CTCATCCTCT CTGCGCCCCA TGCACCCCCA GGCTCTGCAT 
CCAGCCCCTG GACTCCTTGC TTCCCCCCAG CTCCCTGTGC AGATGCAGCC AGCAGGAAAG 
TCGGGCTTTG CAGCTACCAG CCAACCTGGC CCTCGGCTCC CCTTCATCCA ACACAGCCAG 
AACCCGCGAT TCTACCACAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(10)13333-13343(2016 Oct)
Huang XD,Xiao FJ,Wang SX,Yin RH,Lu CR,Li QF,Liu N,Zhang Y,Wang LS,Li PY

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GPS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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