TUSC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TUSC1
Entrez Gene ID	286319
Full Name	tumor suppressor candidate 1
Synonyms	CCDC89B,TSG-9,TSG9
General protein information	Preferred Names tumor suppressor candidate 1 Names tumor suppressor candidate gene 1 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.2
Summary	This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008].
Disorder MIM:	610529

mRNA and Protein(s)

mRNA	Protein	Name
NM_001004125.2	NP_001004125.1	tumor suppressor candidate gene 1 protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	TUSC1	NP_001004125.1
	TUSC1	XP_001106111.1
Mus musculus (house mouse)	Tusc1	NP_081230.1
Bos taurus (cattle)	TUSC1	XP_002689544.1
Pan troglodytes (chimpanzee)	TUSC1	XP_001153427.1

Gene Ontology
Bibliography

Related articles in PubMed

Association of TUSC1 and DPF3 gene polymorphisms with male infertility.
Sato Y, Hasegawa C, Tajima A, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Yamauchi A, Iwamoto T
Journal of assisted reproduction and genetics(2017 Oct)

Tumor Suppressor Candidate 1 Suppresses Cell Growth and Predicts Better Survival in Glioblastoma.
Zhang R, Yu W, Liang G, Jia Z, Chen Z, Zhao L, Yuan Y, Zhou X, Li D, Shen S, Liu N, Zhang A, Wang H, Wang G
Cellular and molecular neurobiology37(1)37-42(2017 Jan)

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis.
Bunyavanich S, Schadt EE, Himes BE, Lasky-Su J, Qiu W, Lazarus R, Ziniti JP, Cohain A, Linderman M, Torgerson DG, Eng CS, Pino-Yanes M, Padhukasahasram B, Yang JJ, Mathias RA, Beaty TH, Li X, Graves P, Romieu I, Navarro Bdel R, Salam MT, Vora H, Nicolae DL, Ober C, Martinez FD, Bleecker ER, Meyers DA, Gauderman WJ, Gilliland F, Burchard EG, Barnes KC, Williams LK, London SJ, Zhang B, Raby BA, Weiss ST
BMC medical genomics748(2014 Aug)

Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer.
Kanda M, Shimizu D, Nomoto S, Hibino S, Oya H, Takami H, Kobayashi D, Yamada S, Inokawa Y, Tanaka C, Fujii T, Sugimoto H, Koike M, Fujiwara M, Kodera Y
Journal of surgical oncology110(2)136-44(2014 Aug)

Identification of intragenic methylation in the TUSC1 gene as a novel prognostic marker of hepatocellular carcinoma.
Shimizu D, Kanda M, Nomoto S, Oya H, Takami H, Hibino S, Suenaga M, Inokawa Y, Hishida M, Takano N, Nishikawa Y, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y
Oncology reports31(3)1305-13(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The expression of TUSC1 is significantly decreased in glioblastoma brain tumor tissues.
Title: Tumor Suppressor Candidate 1 Suppresses Cell Growth and Predicts Better Survival in Glioblastoma.

Results suggested that reduced expression of TUSC1 mRNA was related to poor prognosis and TUSC1 is a putative tumor suppressor gene that is suppressed through intragenic hypermethylation in gastric cancer.
Title: Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer.

TUSC1 is a candidate tumor suppressor gene and intragenic hypermethylation is one of the suppressive mechanisms that regulate TUSC1 transcription in hepatocellular carcinoma.
Title: Identification of intragenic methylation in the TUSC1 gene as a novel prognostic marker of hepatocellular carcinoma.

Results support TUSC1 has tumor suppressor activity as a candidate tumor suppressor gene located on chromosome 9p.
Title: TUSC1, a putative tumor suppressor gene, reduces tumor cell growth in vitro and tumor growth in vivo.

Observational study of gene-disease association. (HuGE Navigator)
Title: Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.

The following TUSC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TUSC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu25918	NM_001004125.2 Latest version!	Homo sapiens tumor suppressor candidate 1 (TUSC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TUSC1 ( NM_001004125.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001004125.1 Homo sapiens tumor suppressor candidate 1 (TUSC1), mRNA.

Price & Availability↑

CloneID	OHu25918
Clone ID Related Accession (Same CDS sequence)	NM_001004125.2
Accession Version	NM_001004125.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Homo sapiens(human)
Product	tumor suppressor candidate gene 1 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL590322.4 and AY168647.2. This sequence is a reference standard in the RefSeqGene project. On Nov 1, 2006 this sequence version replaced NM_001004125.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGACCGA TGTGGCGCAT GCGTGGTGGC GCCACTAGGC GCGGGAGTTG CTGCGGCGGG 
GACGGTGCTG CGGACGGCCG AGGGCCAGGC CGCTCCGGCC GGGCTCGTGG TGGGGGCAGC 
CCCAGCGGCG GCGGCGGCGG CGTGGGCTGG CGAGGCCGCG CGGACGGCGC CCGACAGCAG 
CTGGAGGAGC GGTTTGCCGA CCTGGCGGCG AGCCACTTGG AGGCCATCCG TGCGCGGGAC 
GAGTGGGACC GGCAGAACGC GCGGCTGCGT CAGGAGAACG CCCGGCTGCG GCTCGAGAAC 
CGGCGGCTGA AGCGCGAGAA CCGCAGCCTC TTCCGTCAGG CTTTGCGGCT CCCCGGCGAA 
GGCGGCAACG GGACGCCCGC GGAGGCACGC CGGGTCCCTG AAGAGGCCAG CACGAACCGG 
AGGGCTAGAG ACAGCGGCCG AGAGGACGAG CCGGGCAGCC CCAGGGCCCT GAGGGCCCGA 
CTTGAGAAGC TGGAAGCCAT GTACCGCCGG GCCCTGCTGC AGCTGCACCT CGAGCAGCGG 
GGACCACGTC CGAGCGGGGA CAAGGAGGAG CAGCCTCTAC AGGAACCCGA CTCCGGCCTC 
CGCTCCCGGG ACTCGGAGCC CTCTGGGCCC TGGCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004125.1
CDS	538..1176
Translation	MGPMWRMRGGATRRGSCCGGDGAADGRGPGRSGRARGGGSPSGGGGGVGWRGRADGARQQLEERFADLAASHLEAIRARDEWDRQNARLRQENARLRLENRRLKRENRSLFRQALRLPGEGGNGTPAEARRVPEEASTNRRARDSGREDEPGSPRALRARLEKLEAMYRRALLQLHLEQRGPRPSGDKEEQPLQEPDSGLRSRDSEPSGPWL

Target ORF information:

RefSeq Version	NM_001004125.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tumor suppressor candidate 1 (TUSC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004125.2

ORF Insert Sequence:

ATGGGACCGA TGTGGCGCAT GCGTGGTGGC GCCACTAGGC GCGGGAGTTG CTGCGGCGGG 
GACGGTGCTG CGGACGGCCG AGGGCCAGGC CGCTCCGGCC GGGCTCGTGG TGGGGGCAGC 
CCCAGCGGCG GCGGCGGCGG CGTGGGCTGG CGAGGCCGCG CGGACGGCGC CCGACAGCAG 
CTGGAGGAGC GGTTTGCCGA CCTGGCGGCG AGCCACTTGG AGGCCATCCG TGCGCGGGAC 
GAGTGGGACC GGCAGAACGC GCGGCTGCGT CAGGAGAACG CCCGGCTGCG GCTCGAGAAC 
CGGCGGCTGA AGCGCGAGAA CCGCAGCCTC TTCCGTCAGG CTTTGCGGCT CCCCGGCGAA 
GGCGGCAACG GGACGCCCGC GGAGGCACGC CGGGTCCCTG AAGAGGCCAG CACGAACCGG 
AGGGCTAGAG ACAGCGGCCG AGAGGACGAG CCGGGCAGCC CCAGGGCCCT GAGGGCCCGA 
CTTGAGAAGC TGGAAGCCAT GTACCGCCGG GCCCTGCTGC AGCTGCACCT CGAGCAGCGG 
GGACCACGTC CGAGCGGGGA CAAGGAGGAG CAGCCTCTAC AGGAACCCGA CTCCGGCCTC 
CGCTCCCGGG ACTCGGAGCC CTCTGGGCCC TGGCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of TUSC1 and DPF3 gene polymorphisms with male infertility.
Journal of assisted reproduction and genetics(2017 Oct)
Sato Y,Hasegawa C,Tajima A,Nozawa S,Yoshiike M,Koh E,Kanaya J,Namiki M,Matsumiya K,Tsujimura A,Komatsu K,Itoh N,Eguchi J,Yamauchi A,Iwamoto T

Tumor Suppressor Candidate 1 Suppresses Cell Growth and Predicts Better Survival in Glioblastoma.
Cellular and molecular neurobiology37(1)37-42(2017 Jan)
Zhang R,Yu W,Liang G,Jia Z,Chen Z,Zhao L,Yuan Y,Zhou X,Li D,Shen S,Liu N,Zhang A,Wang H,Wang G

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis.
BMC medical genomics748(2014 Aug)
Bunyavanich S,Schadt EE,Himes BE,Lasky-Su J,Qiu W,Lazarus R,Ziniti JP,Cohain A,Linderman M,Torgerson DG,Eng CS,Pino-Yanes M,Padhukasahasram B,Yang JJ,Mathias RA,Beaty TH,Li X,Graves P,Romieu I,Navarro Bdel R,Salam MT,Vora H,Nicolae DL,Ober C,Martinez FD,Bleecker ER,Meyers DA,Gauderman WJ,Gilliland F,Burchard EG,Barnes KC,Williams LK,London SJ,Zhang B,Raby BA,Weiss ST

Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer.
Journal of surgical oncology110(2)136-44(2014 Aug)
Kanda M,Shimizu D,Nomoto S,Hibino S,Oya H,Takami H,Kobayashi D,Yamada S,Inokawa Y,Tanaka C,Fujii T,Sugimoto H,Koike M,Fujiwara M,Kodera Y

Identification of intragenic methylation in the TUSC1 gene as a novel prognostic marker of hepatocellular carcinoma.
Oncology reports31(3)1305-13(2014 Mar)
Shimizu D,Kanda M,Nomoto S,Oya H,Takami H,Hibino S,Suenaga M,Inokawa Y,Hishida M,Takano N,Nishikawa Y,Yamada S,Fujii T,Nakayama G,Sugimoto H,Koike M,Fujiwara M,Kodera Y

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TUSC1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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FAX

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