MLNR cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MLNR
Entrez Gene ID	2862
Full Name	motilin receptor
Synonyms	GPR38,MTLR1
General protein information	Preferred Names motilin receptor Names motilin receptor G protein-coupled receptor 38
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q14.2
Summary	Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011].
Disorder MIM:	602885

mRNA and Protein(s)

mRNA	Protein	Name
NM_001507.1	NP_001498.1	motilin receptor

Pathways from BioSystems

Homologies

	MLNR	XP_001101857.1
Danio rerio (zebrafish)	LOC100536406	XP_003200046.1
Canis lupus familiaris (dog)	MLNR	NP_001121536.1
Homo sapiens (human)	MLNR	NP_001498.1
Bos taurus (cattle)	MLNR	XP_002691880.2
Gallus gallus (chicken)	MLNR	NP_001120785.1
Xenopus tropicalis (tropical clawed frog)	mlnr	XP_002935793.1

Gene Ontology
Bibliography

Related articles in PubMed

Critical residues in the transmembrane helical bundle domains of the human motilin receptor for erythromycin binding and activity.
Utsunomiya S, Matsuura B, Ueda T, Miyake T, Furukawa S, Kumagi T, Ikeda Y, Abe M, Hiasa Y, Onji M
Regulatory peptides18017-25(2013 Jan)

A relationship between motilin and growth hormone secretagogue receptors.
Nunoi H, Matsuura B, Utsunomiya S, Ueda T, Miyake T, Furukawa S, Kumagi T, Ikeda Y, Abe M, Hiasa Y, Onji M
Regulatory peptides176(1-3)28-35(2012 Jun)

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T
Nephron. Clinical practice115(4)c237-43(2010)

Desensitization and internalization of the human motilin receptor is independent of the C-terminal tail.
Mitselos A, Peeters TL, Depoortere I
Peptides29(7)1167-75(2008 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data support important roles of new regions in the TM domains of the motilin receptor for erythromycin action, suggesting differential mechanisms of actions by peptidyl and non-peptidyl ligands
Title: Critical residues in the transmembrane helical bundle domains of the human motilin receptor for erythromycin binding and activity.

The data suggested that in species expressing both motilin-MR and ghrelin-GHSR, there is a compensatory relationship in vivo.
Title: A relationship between motilin and growth hormone secretagogue receptors.

Observational study of gene-disease association. (HuGE Navigator)
Title: L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

Desensitization and internalization of MLNR is independent of the C-terminal tail.
Title: Desensitization and internalization of the human motilin receptor is independent of the C-terminal tail.

The motilin receptor is expressed in human colonic and ileal smooth muscle. Further, motilin receptor expression was also shown in the mucosa.
Title: Motilin receptor expression in smooth muscle, myenteric plexus, and mucosa of human inflamed and noninflamed intestine.

The following MLNR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MLNR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18969	NM_001507.1 Latest version!	Homo sapiens motilin receptor (MLNR), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$174.50-$244.30 $349.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MLNR ( NM_001507.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001498.1 Homo sapiens motilin receptor (MLNR), mRNA.

Price & Availability↑

CloneID	OHu18969
Clone ID Related Accession (Same CDS sequence)	NM_001507.1
Accession Version	NM_001507.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	motilin receptor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY603964.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY603964.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145240, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000218721.1/ ENSP00000218721.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGGCAGCC CCTGGAACGG CAGCGACGGC CCCGAGGGGG CGCGGGAGCC GCCGTGGCCC 
GCGCTGCCGC CTTGCGACGA GCGCCGCTGC TCGCCCTTTC CCCTGGGGGC GCTGGTGCCG 
GTGACCGCTG TGTGCCTGTG CCTGTTCGTC GTCGGGGTGA GCGGCAACGT GGTGACCGTG 
ATGCTGATCG GGCGCTACCG GGACATGCGG ACCACCACCA ACTTGTACCT GGGCAGCATG 
GCCGTGTCCG ACCTACTCAT CCTGCTCGGG CTGCCGTTCG ACCTGTACCG CCTCTGGCGC 
TCGCGGCCCT GGGTGTTCGG GCCGCTGCTC TGCCGCCTGT CCCTCTACGT GGGCGAGGGC 
TGCACCTACG CCACGCTGCT GCACATGACC GCGCTCAGCG TCGAGCGCTA CCTGGCCATC 
TGCCGCCCGC TCCGCGCCCG CGTCTTGGTC ACCCGGCGCC GCGTCCGCGC GCTCATCGCT 
GTGCTCTGGG CCGTGGCGCT GCTCTCTGCC GGTCCCTTCT TGTTCCTGGT GGGCGTCGAG 
CAGGACCCCG GCATCTCCGT AGTCCCGGGC CTCAATGGCA CCGCGCGGAT CGCCTCCTCG 
CCTCTCGCCT CGTCGCCGCC TCTCTGGCTC TCGCGGGCGC CACCGCCGTC CCCGCCGTCG 
GGGCCCGAGA CCGCGGAGGC CGCGGCGCTG TTCAGCCGCG AATGCCGGCC GAGCCCCGCG 
CAGCTGGGCG CGCTGCGTGT CATGCTGTGG GTCACCACCG CCTACTTCTT CCTGCCCTTT 
CTGTGCCTCA GCATCCTCTA CGGGCTCATC GGGCGGGAGC TGTGGAGCAG CCGGCGGCCG 
CTGCGAGGCC CGGCCGCCTC GGGGCGGGAG AGAGGCCACC GGCAGACCGT CCGCGTCCTG 
CTGGTGGTGG TTCTGGCATT TATAATTTGC TGGTTGCCCT TCCACGTTGG CAGAATCATT 
TACATAAACA CGGAAGATTC GCGGATGATG TACTTCTCTC AGTACTTTAA CATCGTCGCT 
CTGCAACTTT TCTATCTGAG CGCATCTATC AACCCAATCC TCTACAACCT CATTTCAAAG 
AAGTACAGAG CGGCGGCCTT TAAACTGCTG CTCGCAAGGA AGTCCAGGCC GAGAGGCTTC 
CACAGAAGCA GGGACACTGC GGGGGAAGTT GCAGGGGACA CTGGAGGAGA CACGGTGGGC 
TACACCGAGA CAAGCGCTAA CGTGAAGACG ATGGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001498.1
CDS	1..1239
Translation	MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG

Target ORF information:

RefSeq Version	NM_001507.1
Organism	Homo sapiens(human)
Definition	Homo sapiens motilin receptor (MLNR), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001507.1

ORF Insert Sequence:

ATGGGCAGCC CCTGGAACGG CAGCGACGGC CCCGAGGGGG CGCGGGAGCC GCCGTGGCCC 
GCGCTGCCGC CTTGCGACGA GCGCCGCTGC TCGCCCTTTC CCCTGGGGGC GCTGGTGCCG 
GTGACCGCTG TGTGCCTGTG CCTGTTCGTC GTCGGGGTGA GCGGCAACGT GGTGACCGTG 
ATGCTGATCG GGCGCTACCG GGACATGCGG ACCACCACCA ACTTGTACCT GGGCAGCATG 
GCCGTGTCCG ACCTACTCAT CCTGCTCGGG CTGCCGTTCG ACCTGTACCG CCTCTGGCGC 
TCGCGGCCCT GGGTGTTCGG GCCGCTGCTC TGCCGCCTGT CCCTCTACGT GGGCGAGGGC 
TGCACCTACG CCACGCTGCT GCACATGACC GCGCTCAGCG TCGAGCGCTA CCTGGCCATC 
TGCCGCCCGC TCCGCGCCCG CGTCTTGGTC ACCCGGCGCC GCGTCCGCGC GCTCATCGCT 
GTGCTCTGGG CCGTGGCGCT GCTCTCTGCC GGTCCCTTCT TGTTCCTGGT GGGCGTCGAG 
CAGGACCCCG GCATCTCCGT AGTCCCGGGC CTCAATGGCA CCGCGCGGAT CGCCTCCTCG 
CCTCTCGCCT CGTCGCCGCC TCTCTGGCTC TCGCGGGCGC CACCGCCGTC CCCGCCGTCG 
GGGCCCGAGA CCGCGGAGGC CGCGGCGCTG TTCAGCCGCG AATGCCGGCC GAGCCCCGCG 
CAGCTGGGCG CGCTGCGTGT CATGCTGTGG GTCACCACCG CCTACTTCTT CCTGCCCTTT 
CTGTGCCTCA GCATCCTCTA CGGGCTCATC GGGCGGGAGC TGTGGAGCAG CCGGCGGCCG 
CTGCGAGGCC CGGCCGCCTC GGGGCGGGAG AGAGGCCACC GGCAGACCGT CCGCGTCCTG 
CTGGTGGTGG TTCTGGCATT TATAATTTGC TGGTTGCCCT TCCACGTTGG CAGAATCATT 
TACATAAACA CGGAAGATTC GCGGATGATG TACTTCTCTC AGTACTTTAA CATCGTCGCT 
CTGCAACTTT TCTATCTGAG CGCATCTATC AACCCAATCC TCTACAACCT CATTTCAAAG 
AAGTACAGAG CGGCGGCCTT TAAACTGCTG CTCGCAAGGA AGTCCAGGCC GAGAGGCTTC 
CACAGAAGCA GGGACACTGC GGGGGAAGTT GCAGGGGACA CTGGAGGAGA CACGGTGGGC 
TACACCGAGA CAAGCGCTAA CGTGAAGACG ATGGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Critical residues in the transmembrane helical bundle domains of the human motilin receptor for erythromycin binding and activity.
Regulatory peptides18017-25(2013 Jan)
Utsunomiya S,Matsuura B,Ueda T,Miyake T,Furukawa S,Kumagi T,Ikeda Y,Abe M,Hiasa Y,Onji M

A relationship between motilin and growth hormone secretagogue receptors.
Regulatory peptides176(1-3)28-35(2012 Jun)
Nunoi H,Matsuura B,Utsunomiya S,Ueda T,Miyake T,Furukawa S,Kumagi T,Ikeda Y,Abe M,Hiasa Y,Onji M

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Nephron. Clinical practice115(4)c237-43(2010)
Yokoyama K,Urashima M,Ohkido I,Kono T,Yoshida T,Muramatsu M,Niu T,Hosoya T

Desensitization and internalization of the human motilin receptor is independent of the C-terminal tail.
Peptides29(7)1167-75(2008 Jul)
Mitselos A,Peeters TL,Depoortere I

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

MLNR cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報