KLK9 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLK9
Entrez Gene ID	284366
Full Name	kallikrein related peptidase 9
Synonyms	KLK-L3,KLKL3
General protein information	Preferred Names kallikrein related peptidase 9 Names kallikrein-9 kallikrein-like protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.41
Summary	The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010].
Disorder MIM:	605504

mRNA and Protein(s)

mRNA	Protein	Name
NM_012315.1	NP_036447.1	kallikrein-9 precursor
NM_012315.2	NP_036447.1	kallikrein-9 precursor

Pathways from BioSystems

Homologies

	KLK9	XP_002801412.1
Homo sapiens (human)	KLK9	NP_036447.1
Mus musculus (house mouse)	Klk9	NP_082936.2
Rattus norvegicus (Norway rat)	Klk9	NP_001099723.1
Canis lupus familiaris (dog)	KLK9	NP_001165244.2
Bos taurus (cattle)	KLK9	NP_001192913.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing.
Adamopoulos PG, Kontos CK, Scorilas A
Scientific reports7(1)17299(2017 Dec)

Biochemical and functional characterization of the human tissue kallikrein 9.
Filippou PS, Farkona S, Brinc D, Yu Y, Prassas I, Diamandis EP
The Biochemical journal474(14)2417-2433(2017 07)

Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.
Geng X, Liu Y, Diersch S, Kotzsch M, Grill S, Weichert W, Kiechle M, Magdolen V, Dorn J
PloS one12(11)e0186847(2017)

Prognostic significance of multiple kallikreins in high-grade astrocytoma.
Drucker KL, Gianinni C, Decker PA, Diamandis EP, Scarisbrick IA
BMC cancer15565(2015 Aug)

Human tissue kallikrein 9 in asthmatic patients.
Nasim FU, Ejaz S, Ashraf M, Ahmad S
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology114(4)347-349.e6(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that mature KLK9 (kallikrein 9) is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at P1 cleavage position; substrate specificity of KLK9 appears to extend to KLK10 and midkine; enzyme activity is enhanced by Mg2+ and Ca2+, but is reversibly attenuated by Zn2+; KLK9 is inhibited in vitro by many naturally occurring or synthetic protease inhibitors.
Title: Biochemical and functional characterization of the human tissue kallikrein 9.

Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases
Title: Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.

Data demonstrate that elevated levels of KLK6, KLK7 and KLK9 proteins are associated with poor glioblastoma patients survival.
Title: Prognostic significance of multiple kallikreins in high-grade astrocytoma.

the serum level has the potential to be used as a biomarker for asthma
Title: Human tissue kallikrein 9 in asthmatic patients.

Observational study of gene-disease association. (HuGE Navigator)
Title: Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.

The following KLK9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLK9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19324	NM_012315.2 Latest version!	Homo sapiens kallikrein related peptidase 9 (KLK9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
View Old Accession Versions >>
OHu19324	NM_012315.1	Homo sapiens kallikrein related peptidase 9 (KLK9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLK9 ( NM_012315.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_036447.1 Homo sapiens kallikrein related peptidase 9 (KLK9), mRNA.

Price & Availability↑

CloneID	OHu19324
Clone ID Related Accession (Same CDS sequence)	NM_012315.1 , NM_012315.2
Accession Version	NM_012315.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-30
Organism	Homo sapiens(human)
Product	kallikrein-9 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF135026.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: DQ267419.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCTGG GACTCCTCTG TGCTCTGCTC TCTCTGCTGG CAGGGCATGG CTGGGCAGAC 
ACCCGTGCCA TCGGGGCCGA GGAATGTCGC CCCAACTCCC AGCCTTGGCA GGCCGGCCTC 
TTCCACCTTA CTCGGCTCTT CTGTGGGGCG ACCCTCATCA GTGACCGCTG GCTGCTCACA 
GCTGCCCACT GCCGCAAGCC GTATCTGTGG GTCCGCCTTG GAGAGCACCA CCTCTGGAAA 
TGGGAGGGTC CGGAGCAGCT GTTCCGGGTT ACGGACTTCT TCCCCCACCC TGGCTTCAAC 
AAGGACCTCA GCGCCAATGA CCACAATGAT GACATCATGC TGATCCGCCT GCCCAGGCAG 
GCACGTCTGA GTCCTGCTGT GCAGCCCCTC AACCTCAGCC AGACCTGTGT CTCCCCAGGC 
ATGCAGTGTC TCATCTCAGG CTGGGGGGCC GTGTCCAGCC CCAAGGCGCT GTTTCCAGTC 
ACACTGCAGT GTGCCAACAT CAGCATCCTG GAGAACAAAC TCTGTCACTG GGCATACCCT 
GGACACATCT CGGACAGCAT GCTCTGTGCG GGCCTGTGGG AGGGGGGCCG AGGTTCCTGC 
CAGGGTGACT CTGGGGGCCC CCTGGTTTGC AATGGAACCT TGGCAGGCGT GGTGTCTGGG 
GGTGCTGAGC CCTGCTCCAG ACCCCGGCGC CCCGCAGTCT ACACCAGCGT ATGCCACTAC 
CTTGACTGGA TCCAAGAAAT CATGGAGAAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036447.1
CDS	88..840
Translation	MKLGLLCALLSLLAGHGWADTRAIGAEECRPNSQPWQAGLFHLTRLFCGATLISDRWLLTAAHCRKPYLWVRLGEHHLWKWEGPEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPRQARLSPAVQPLNLSQTCVSPGMQCLISGWGAVSSPKALFPVTLQCANISILENKLCHWAYPGHISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYTSVCHYLDWIQEIMEN

Target ORF information:

RefSeq Version	NM_012315.1
Organism	Homo sapiens(human)
Definition	Homo sapiens kallikrein related peptidase 9 (KLK9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012315.1

ORF Insert Sequence:

ATGAAGCTGG GACTCCTCTG TGCTCTGCTC TCTCTGCTGG CAGGGCATGG CTGGGCAGAC 
ACCCGTGCCA TCGGGGCCGA GGAATGTCGC CCCAACTCCC AGCCTTGGCA GGCCGGCCTC 
TTCCACCTTA CTCGGCTCTT CTGTGGGGCG ACCCTCATCA GTGACCGCTG GCTGCTCACA 
GCTGCCCACT GCCGCAAGCC GTATCTGTGG GTCCGCCTTG GAGAGCACCA CCTCTGGAAA 
TGGGAGGGTC CGGAGCAGCT GTTCCGGGTT ACGGACTTCT TCCCCCACCC TGGCTTCAAC 
AAGGACCTCA GCGCCAATGA CCACAATGAT GACATCATGC TGATCCGCCT GCCCAGGCAG 
GCACGTCTGA GTCCTGCTGT GCAGCCCCTC AACCTCAGCC AGACCTGTGT CTCCCCAGGC 
ATGCAGTGTC TCATCTCAGG CTGGGGGGCC GTGTCCAGCC CCAAGGCGCT GTTTCCAGTC 
ACACTGCAGT GTGCCAACAT CAGCATCCTG GAGAACAAAC TCTGTCACTG GGCATACCCT 
GGACACATCT CGGACAGCAT GCTCTGTGCG GGCCTGTGGG AGGGGGGCCG AGGTTCCTGC 
CAGGGTGACT CTGGGGGCCC CCTGGTTTGC AATGGAACCT TGGCAGGCGT GGTGTCTGGG 
GGTGCTGAGC CCTGCTCCAG ACCCCGGCGC CCCGCAGTCT ACACCAGCGT ATGCCACTAC 
CTTGACTGGA TCCAAGAAAT CATGGAGAAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLK9 ( NM_012315.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036447.1 Homo sapiens kallikrein related peptidase 9 (KLK9), mRNA.

Price & Availability↑

CloneID	OHu19324
Clone ID Related Accession (Same CDS sequence)	NM_012315.1 , NM_012315.2
Accession Version	NM_012315.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	kallikrein-9 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011473.4. This sequence is a reference standard in the RefSeqGene project. On Nov 26, 2018 this sequence version replaced NM_012315.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: DQ267419.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000594211.2/ ENSP00000469417.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCTGG GACTCCTCTG TGCTCTGCTC TCTCTGCTGG CAGGGCATGG CTGGGCAGAC 
ACCCGTGCCA TCGGGGCCGA GGAATGTCGC CCCAACTCCC AGCCTTGGCA GGCCGGCCTC 
TTCCACCTTA CTCGGCTCTT CTGTGGGGCG ACCCTCATCA GTGACCGCTG GCTGCTCACA 
GCTGCCCACT GCCGCAAGCC GTATCTGTGG GTCCGCCTTG GAGAGCACCA CCTCTGGAAA 
TGGGAGGGTC CGGAGCAGCT GTTCCGGGTT ACGGACTTCT TCCCCCACCC TGGCTTCAAC 
AAGGACCTCA GCGCCAATGA CCACAATGAT GACATCATGC TGATCCGCCT GCCCAGGCAG 
GCACGTCTGA GTCCTGCTGT GCAGCCCCTC AACCTCAGCC AGACCTGTGT CTCCCCAGGC 
ATGCAGTGTC TCATCTCAGG CTGGGGGGCC GTGTCCAGCC CCAAGGCGCT GTTTCCAGTC 
ACACTGCAGT GTGCCAACAT CAGCATCCTG GAGAACAAAC TCTGTCACTG GGCATACCCT 
GGACACATCT CGGACAGCAT GCTCTGTGCG GGCCTGTGGG AGGGGGGCCG AGGTTCCTGC 
CAGGGTGACT CTGGGGGCCC CCTGGTTTGC AATGGAACCT TGGCAGGCGT GGTGTCTGGG 
GGTGCTGAGC CCTGCTCCAG ACCCCGGCGC CCCGCAGTCT ACACCAGCGT ATGCCACTAC 
CTTGACTGGA TCCAAGAAAT CATGGAGAAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036447.1
CDS	46..798
Translation	MKLGLLCALLSLLAGHGWADTRAIGAEECRPNSQPWQAGLFHLTRLFCGATLISDRWLLTAAHCRKPYLWVRLGEHHLWKWEGPEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPRQARLSPAVQPLNLSQTCVSPGMQCLISGWGAVSSPKALFPVTLQCANISILENKLCHWAYPGHISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYTSVCHYLDWIQEIMEN

Target ORF information:

RefSeq Version	NM_012315.2
Organism	Homo sapiens(human)
Definition	Homo sapiens kallikrein related peptidase 9 (KLK9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012315.2

ORF Insert Sequence:

ATGAAGCTGG GACTCCTCTG TGCTCTGCTC TCTCTGCTGG CAGGGCATGG CTGGGCAGAC 
ACCCGTGCCA TCGGGGCCGA GGAATGTCGC CCCAACTCCC AGCCTTGGCA GGCCGGCCTC 
TTCCACCTTA CTCGGCTCTT CTGTGGGGCG ACCCTCATCA GTGACCGCTG GCTGCTCACA 
GCTGCCCACT GCCGCAAGCC GTATCTGTGG GTCCGCCTTG GAGAGCACCA CCTCTGGAAA 
TGGGAGGGTC CGGAGCAGCT GTTCCGGGTT ACGGACTTCT TCCCCCACCC TGGCTTCAAC 
AAGGACCTCA GCGCCAATGA CCACAATGAT GACATCATGC TGATCCGCCT GCCCAGGCAG 
GCACGTCTGA GTCCTGCTGT GCAGCCCCTC AACCTCAGCC AGACCTGTGT CTCCCCAGGC 
ATGCAGTGTC TCATCTCAGG CTGGGGGGCC GTGTCCAGCC CCAAGGCGCT GTTTCCAGTC 
ACACTGCAGT GTGCCAACAT CAGCATCCTG GAGAACAAAC TCTGTCACTG GGCATACCCT 
GGACACATCT CGGACAGCAT GCTCTGTGCG GGCCTGTGGG AGGGGGGCCG AGGTTCCTGC 
CAGGGTGACT CTGGGGGCCC CCTGGTTTGC AATGGAACCT TGGCAGGCGT GGTGTCTGGG 
GGTGCTGAGC CCTGCTCCAG ACCCCGGCGC CCCGCAGTCT ACACCAGCGT ATGCCACTAC 
CTTGACTGGA TCCAAGAAAT CATGGAGAAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing.
Scientific reports7(1)17299(2017 Dec)
Adamopoulos PG,Kontos CK,Scorilas A

Biochemical and functional characterization of the human tissue kallikrein 9.
The Biochemical journal474(14)2417-2433(2017 07)
Filippou PS,Farkona S,Brinc D,Yu Y,Prassas I,Diamandis EP

Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.
PloS one12(11)e0186847(2017)
Geng X,Liu Y,Diersch S,Kotzsch M,Grill S,Weichert W,Kiechle M,Magdolen V,Dorn J

Prognostic significance of multiple kallikreins in high-grade astrocytoma.
BMC cancer15565(2015 Aug)
Drucker KL,Gianinni C,Decker PA,Diamandis EP,Scarisbrick IA

Human tissue kallikrein 9 in asthmatic patients.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology114(4)347-349.e6(2015 Apr)
Nasim FU,Ejaz S,Ashraf M,Ahmad S

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KLK9 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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