PGP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PGP
Entrez Gene ID	283871
Full Name	phosphoglycolate phosphatase
Synonyms	AUM,G3PP,PGPase
General protein information	Preferred Names phosphoglycolate phosphatase Names glycerol-3-phosphate phosphatase aspartate-based ubiquitous Mg(2+)-dependent phosphatase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Disorder MIM:	172280

mRNA and Protein(s)

mRNA	Protein	Name
NM_001042371.3	NP_001035830.1	glycerol-3-phosphate phosphatase
NM_001042371.2	NP_001035830.1	glycerol-3-phosphate phosphatase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PGP	XP_001162359.2
	LOC695591	XP_001084229.2
Canis lupus familiaris (dog)	PGP	XP_005622146.1
Rattus norvegicus (Norway rat)	Pgp	NP_001162623.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011350	XP_309300.4
Caenorhabditis elegans (roundworm)	C53A3.2	NP_504511.1
Caenorhabditis elegans (roundworm)	CELE_K09H11.7	NP_504509.1
Caenorhabditis elegans (roundworm)	C45E5.1	NP_500857.2
Saccharomyces cerevisiae (baker's yeast)	PHO13	NP_010045.1
Kluyveromyces lactis	KLLA0D19382g	XP_453922.1
Schizosaccharomyces pombe (fission yeast)	pho2	NP_596255.1
Neurospora crassa	NCU00088	XP_957212.1
Bos taurus (cattle)	PGP	NP_001033261.1
Caenorhabditis elegans (roundworm)	F44E7.2	NP_504512.1
Magnaporthe oryzae (rice blast fungus)	MGG_10149	XP_003713787.1
Arabidopsis thaliana (thale cress)	PGLP2	NP_199587.1
Gallus gallus (chicken)	PGP	NP_001025809.1
Caenorhabditis elegans (roundworm)	K02D10.1	NP_001122707.1
Oryza sativa (rice)	Os09g0261300	NP_001062708.2
Xenopus tropicalis (tropical clawed frog)	pgp	XP_002932481.1
Homo sapiens (human)	PGP	NP_001035830.1
Mus musculus (house mouse)	Pgp	NP_080230.2
Danio rerio (zebrafish)	pgp	NP_997891.2
Drosophila melanogaster (fruit fly)	CG5567	NP_649015.2
Eremothecium gossypii	AGOS_ABL184W	NP_982763.1

Gene Ontology
Bibliography

Related articles in PubMed

A Guardian Angel Phosphatase for Mainline Carbon Metabolism.
Beaudoin GA, Hanson AD
Trends in biochemical sciences41(11)893-894(2016 Nov)

Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes.
Mugabo Y, Zhao S, Seifried A, Gezzar S, Al-Mass A, Zhang D, Lamontagne J, Attane C, Poursharifi P, Iglesias J, Joly E, Peyot ML, Gohla A, Madiraju SR, Prentki M
Proceedings of the National Academy of Sciences of the United States of America113(4)E430-9(2016 Jan)

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).
Jansson PJ, Yamagishi T, Arvind A, Seebacher N, Gutierrez E, Stacy A, Maleki S, Sharp D, Sahni S, Richardson DR
The Journal of biological chemistry290(15)9588-603(2015 Apr)

Association between P-glycoprotein and lymphoid antigen expression on myeloblasts versus therapy response and survival in de novo acute myeloid leukemia: long-term follow-up results.
Machaczka M, Wahlin BE, Piatkowska-Jakubas B, Rucinska M, Jurczak W, Balana-Nowak A, Klimkowska M, H?gglund H, Skotnicki AB
Medical oncology (Northwood, London, England)29(3)2070-6(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Phosphoglycolate phosphatase rescues central carbon metabolism from toxic secondary metabolites in humans and yeast.
Title: A Guardian Angel Phosphatase for Mainline Carbon Metabolism.

Data indicate that Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance (MDR) via utilization of lysosomal P-glycoprotein (Pgp) transport activity.
Title: Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).

acute myeloid leukemia patients with co-expression of PGP and Ly showed better overall survival compared with PGP(+) patients without Ly expression
Title: Association between P-glycoprotein and lymphoid antigen expression on myeloblasts versus therapy response and survival in de novo acute myeloid leukemia: long-term follow-up results.

expressed in skin lesions from groins and axilla in patients with hidradenitis suppurativa
Title: Cutaneous PGP 9.5 distribution patterns in hidradenitis suppurativa.

the PI3K/Akt pathway is involved in MDR in lymphoma cell lines and PI3K/Akt inhibition correlates down-regulation of NF-kappaB activity and inhibition Pgp function.
Title: PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines.

The following PGP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PGP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14417	NM_001042371.3 Latest version!	Homo sapiens phosphoglycolate phosphatase (PGP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu14417	NM_001042371.2	Homo sapiens phosphoglycolate phosphatase (PGP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PGP ( NM_001042371.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035830.1 Homo sapiens phosphoglycolate phosphatase (PGP), mRNA.

Price & Availability↑

CloneID	OHu14417
Clone ID Related Accession (Same CDS sequence)	NM_001042371.3 , NM_001042371.2
Accession Version	NM_001042371.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	glycerol-3-phosphate phosphatase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009065.8, AW161386.1, BC035985.1, DA336356.1 and AK026146.1. On May 17, 2019 this sequence version replaced NM_001042371.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.10732.1, SRR1803616.239423.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000333503.8/ ENSP00000330918.7 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCGGCGG CGGAGGCCGG TGGCGACGAC GCCCGCTGCG TGCGGCTGAG CGCCGAGCGG 
GCACAGGCGC TGCTGGCCGA CGTGGACACG CTGCTGTTCG ACTGCGACGG CGTGCTGTGG 
CGCGGGGAGA CCGCCGTGCC TGGCGCGCCC GAGGCCCTGC GGGCGCTGCG AGCCCGCGGC 
AAGCGCCTGG GCTTCATCAC CAACAACAGC AGCAAGACCC GCGCTGCCTA CGCCGAGAAG 
CTGCGGCGCC TGGGCTTCGG CGGCCCCGCG GGGCCCGGCG CCAGCCTGGA GGTCTTCGGC 
ACGGCCTACT GCACCGCGCT CTACCTGCGC CAGCGCCTGG CCGGCGCCCC CGCGCCCAAG 
GCCTACGTGC TGGGCAGCCC AGCCCTGGCC GCGGAGCTGG AGGCCGTGGG CGTCGCCAGC 
GTGGGCGTGG GGCCCGAGCC ACTGCAGGGC GAGGGTCCCG GCGACTGGCT GCACGCGCCG 
CTGGAGCCCG ACGTGCGCGC GGTGGTGGTG GGCTTTGACC CGCACTTCAG CTACATGAAG 
CTCACCAAGG CCCTGCGCTA CCTGCAGCAG CCCGGCTGCC TGCTCGTGGG CACCAACATG 
GACAACCGGC TTCCGCTTGA GAACGGCCGC TTCATCGCGG GTACCGGGTG TCTGGTCCGA 
GCCGTGGAGA TGGCCGCCCA GCGCCAGGCC GACATCATCG GGAAGCCCAG CCGCTTCATT 
TTCGACTGCG TGTCCCAGGA ATACGGCATC AACCCCGAGC GCACCGTCAT GGTGGGAGAC 
CGCCTGGACA CAGACATCCT CCTAGGCGCC ACCTGTGGCC TGAAGACCAT CCTGACCCTC 
ACCGGAGTCT CCACTCTAGG GGATGTGAAG AATAATCAGG AAAGTGACTG CGTGTCTAAG 
AAGAAAATGG TCCCTGACTT CTATGTTGAC AGCATAGCCG ACCTTTTGCC TGCCCTTCAA 
GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035830.1
CDS	64..1029
Translation	MAAAEAGGDDARCVRLSAERAQALLADVDTLLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGGPAGPGASLEVFGTAYCTALYLRQRLAGAPAPKAYVLGSPALAAELEAVGVASVGVGPEPLQGEGPGDWLHAPLEPDVRAVVVGFDPHFSYMKLTKALRYLQQPGCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKTILTLTGVSTLGDVKNNQESDCVSKKKMVPDFYVDSIADLLPALQG

Target ORF information:

RefSeq Version	NM_001042371.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoglycolate phosphatase (PGP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042371.3

ORF Insert Sequence:

ATGGCGGCGG CGGAGGCCGG TGGCGACGAC GCCCGCTGCG TGCGGCTGAG CGCCGAGCGG 
GCACAGGCGC TGCTGGCCGA CGTGGACACG CTGCTGTTCG ACTGCGACGG CGTGCTGTGG 
CGCGGGGAGA CCGCCGTGCC TGGCGCGCCC GAGGCCCTGC GGGCGCTGCG AGCCCGCGGC 
AAGCGCCTGG GCTTCATCAC CAACAACAGC AGCAAGACCC GCGCTGCCTA CGCCGAGAAG 
CTGCGGCGCC TGGGCTTCGG CGGCCCCGCG GGGCCCGGCG CCAGCCTGGA GGTCTTCGGC 
ACGGCCTACT GCACCGCGCT CTACCTGCGC CAGCGCCTGG CCGGCGCCCC CGCGCCCAAG 
GCCTACGTGC TGGGCAGCCC AGCCCTGGCC GCGGAGCTGG AGGCCGTGGG CGTCGCCAGC 
GTGGGCGTGG GGCCCGAGCC ACTGCAGGGC GAGGGTCCCG GCGACTGGCT GCACGCGCCG 
CTGGAGCCCG ACGTGCGCGC GGTGGTGGTG GGCTTTGACC CGCACTTCAG CTACATGAAG 
CTCACCAAGG CCCTGCGCTA CCTGCAGCAG CCCGGCTGCC TGCTCGTGGG CACCAACATG 
GACAACCGGC TTCCGCTTGA GAACGGCCGC TTCATCGCGG GTACCGGGTG TCTGGTCCGA 
GCCGTGGAGA TGGCCGCCCA GCGCCAGGCC GACATCATCG GGAAGCCCAG CCGCTTCATT 
TTCGACTGCG TGTCCCAGGA ATACGGCATC AACCCCGAGC GCACCGTCAT GGTGGGAGAC 
CGCCTGGACA CAGACATCCT CCTAGGCGCC ACCTGTGGCC TGAAGACCAT CCTGACCCTC 
ACCGGAGTCT CCACTCTAGG GGATGTGAAG AATAATCAGG AAAGTGACTG CGTGTCTAAG 
AAGAAAATGG TCCCTGACTT CTATGTTGAC AGCATAGCCG ACCTTTTGCC TGCCCTTCAA 
GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PGP ( NM_001042371.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035830.1 Homo sapiens phosphoglycolate phosphatase (PGP), mRNA.

Price & Availability↑

CloneID	OHu14417
Clone ID Related Accession (Same CDS sequence)	NM_001042371.3 , NM_001042371.2
Accession Version	NM_001042371.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	glycerol-3-phosphate phosphatase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AW161386.1, BC035985.1, DA336356.1, AK026146.1 and AC009065.8. On or before Jul 31, 2014 this sequence version replaced NM_024118.1, NM_001042371.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.239423.1, SRR1660809.10732.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGG CGGAGGCCGG TGGCGACGAC GCCCGCTGCG TGCGGCTGAG CGCCGAGCGG 
GCACAGGCGC TGCTGGCCGA CGTGGACACG CTGCTGTTCG ACTGCGACGG CGTGCTGTGG 
CGCGGGGAGA CCGCCGTGCC TGGCGCGCCC GAGGCCCTGC GGGCGCTGCG AGCCCGCGGC 
AAGCGCCTGG GCTTCATCAC CAACAACAGC AGCAAGACCC GCGCTGCCTA CGCCGAGAAG 
CTGCGGCGCC TGGGCTTCGG CGGCCCCGCG GGGCCCGGCG CCAGCCTGGA GGTCTTCGGC 
ACGGCCTACT GCACCGCGCT CTACCTGCGC CAGCGCCTGG CCGGCGCCCC CGCGCCCAAG 
GCCTACGTGC TGGGCAGCCC AGCCCTGGCC GCGGAGCTGG AGGCCGTGGG CGTCGCCAGC 
GTGGGCGTGG GGCCCGAGCC ACTGCAGGGC GAGGGTCCCG GCGACTGGCT GCACGCGCCG 
CTGGAGCCCG ACGTGCGCGC GGTGGTGGTG GGCTTTGACC CGCACTTCAG CTACATGAAG 
CTCACCAAGG CCCTGCGCTA CCTGCAGCAG CCCGGCTGCC TGCTCGTGGG CACCAACATG 
GACAACCGGC TTCCGCTTGA GAACGGCCGC TTCATCGCGG GTACCGGGTG TCTGGTCCGA 
GCCGTGGAGA TGGCCGCCCA GCGCCAGGCC GACATCATCG GGAAGCCCAG CCGCTTCATT 
TTCGACTGCG TGTCCCAGGA ATACGGCATC AACCCCGAGC GCACCGTCAT GGTGGGAGAC 
CGCCTGGACA CAGACATCCT CCTAGGCGCC ACCTGTGGCC TGAAGACCAT CCTGACCCTC 
ACCGGAGTCT CCACTCTAGG GGATGTGAAG AATAATCAGG AAAGTGACTG CGTGTCTAAG 
AAGAAAATGG TCCCTGACTT CTATGTTGAC AGCATAGCCG ACCTTTTGCC TGCCCTTCAA 
GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035830.1
CDS	45..1010
Translation	MAAAEAGGDDARCVRLSAERAQALLADVDTLLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGGPAGPGASLEVFGTAYCTALYLRQRLAGAPAPKAYVLGSPALAAELEAVGVASVGVGPEPLQGEGPGDWLHAPLEPDVRAVVVGFDPHFSYMKLTKALRYLQQPGCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKTILTLTGVSTLGDVKNNQESDCVSKKKMVPDFYVDSIADLLPALQG

Target ORF information:

RefSeq Version	NM_001042371.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoglycolate phosphatase (PGP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042371.2

ORF Insert Sequence:

ATGGCGGCGG CGGAGGCCGG TGGCGACGAC GCCCGCTGCG TGCGGCTGAG CGCCGAGCGG 
GCACAGGCGC TGCTGGCCGA CGTGGACACG CTGCTGTTCG ACTGCGACGG CGTGCTGTGG 
CGCGGGGAGA CCGCCGTGCC TGGCGCGCCC GAGGCCCTGC GGGCGCTGCG AGCCCGCGGC 
AAGCGCCTGG GCTTCATCAC CAACAACAGC AGCAAGACCC GCGCTGCCTA CGCCGAGAAG 
CTGCGGCGCC TGGGCTTCGG CGGCCCCGCG GGGCCCGGCG CCAGCCTGGA GGTCTTCGGC 
ACGGCCTACT GCACCGCGCT CTACCTGCGC CAGCGCCTGG CCGGCGCCCC CGCGCCCAAG 
GCCTACGTGC TGGGCAGCCC AGCCCTGGCC GCGGAGCTGG AGGCCGTGGG CGTCGCCAGC 
GTGGGCGTGG GGCCCGAGCC ACTGCAGGGC GAGGGTCCCG GCGACTGGCT GCACGCGCCG 
CTGGAGCCCG ACGTGCGCGC GGTGGTGGTG GGCTTTGACC CGCACTTCAG CTACATGAAG 
CTCACCAAGG CCCTGCGCTA CCTGCAGCAG CCCGGCTGCC TGCTCGTGGG CACCAACATG 
GACAACCGGC TTCCGCTTGA GAACGGCCGC TTCATCGCGG GTACCGGGTG TCTGGTCCGA 
GCCGTGGAGA TGGCCGCCCA GCGCCAGGCC GACATCATCG GGAAGCCCAG CCGCTTCATT 
TTCGACTGCG TGTCCCAGGA ATACGGCATC AACCCCGAGC GCACCGTCAT GGTGGGAGAC 
CGCCTGGACA CAGACATCCT CCTAGGCGCC ACCTGTGGCC TGAAGACCAT CCTGACCCTC 
ACCGGAGTCT CCACTCTAGG GGATGTGAAG AATAATCAGG AAAGTGACTG CGTGTCTAAG 
AAGAAAATGG TCCCTGACTT CTATGTTGAC AGCATAGCCG ACCTTTTGCC TGCCCTTCAA 
GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Guardian Angel Phosphatase for Mainline Carbon Metabolism.
Trends in biochemical sciences41(11)893-894(2016 Nov)
Beaudoin GA,Hanson AD

Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America113(4)E430-9(2016 Jan)
Mugabo Y,Zhao S,Seifried A,Gezzar S,Al-Mass A,Zhang D,Lamontagne J,Attane C,Poursharifi P,Iglesias J,Joly E,Peyot ML,Gohla A,Madiraju SR,Prentki M

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).
The Journal of biological chemistry290(15)9588-603(2015 Apr)
Jansson PJ,Yamagishi T,Arvind A,Seebacher N,Gutierrez E,Stacy A,Maleki S,Sharp D,Sahni S,Richardson DR

Association between P-glycoprotein and lymphoid antigen expression on myeloblasts versus therapy response and survival in de novo acute myeloid leukemia: long-term follow-up results.
Medical oncology (Northwood, London, England)29(3)2070-6(2012 Sep)
Machaczka M,Wahlin BE,Piatkowska-Jakubas B,Rucinska M,Jurczak W,Balana-Nowak A,Klimkowska M,H?gglund H,Skotnicki AB

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PGP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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