NPBWR2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NPBWR2
Entrez Gene ID	2832
Full Name	neuropeptides B and W receptor 2
Synonyms	GPR8
General protein information	Preferred Names neuropeptides B and W receptor 2 Names neuropeptides B/W receptor type 2 G-protein coupled receptor 8 neuropeptides B/W receptor 2 opioid-somatostatin-like receptor 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.33
Summary	The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008].
Disorder MIM:	600731

mRNA and Protein(s)

mRNA	Protein	Name
NM_005286.4	NP_005277.2	neuropeptides B/W receptor type 2
NM_005286.2	NP_005277.2	neuropeptides B/W receptor type 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LOC771598	XP_003642533.1
Danio rerio (zebrafish)	LOC571123	NP_001025429.1
Xenopus tropicalis (tropical clawed frog)	LOC100487226	XP_004920173.1
Homo sapiens (human)	NPBWR2	NP_005277.2
Pan troglodytes (chimpanzee)	NPBWR2	XP_003953857.1
	NPBWR2	XP_001113051.2
Bos taurus (cattle)	NPBWR2	NP_776500.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of Neuropeptide B (NPB), Neuropeptide W (NPW), and Their Receptors in Chickens: Evidence for NPW Being a Novel Inhibitor of Pituitary GH and Prolactin Secretion.
Bu G, Lin D, Cui L, Huang L, Lv C, Huang S, Wan Y, Fang C, Li J, Wang Y
Endocrinology157(9)3562-76(2016 Sep)

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
Luttrell LM
Molecular biotechnology39(3)239-64(2008 Jul)

Dissociation of heterotrimeric g proteins in cells.
Lambert NA
Science signaling1(25)re5(2008 Jun)

G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.
Mazzocchi G, Rebuffat P, Ziolkowska A, Rossi GP, Malendowicz LK, Nussdorfer GG
The Journal of clinical endocrinology and metabolism90(6)3466-71(2005 Jun)

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.
Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M
Proceedings of the National Academy of Sciences of the United States of America100(10)6251-6(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mainly expressed in brain or pituitary
Title: Characterization of Neuropeptide B (NPB), Neuropeptide W (NPW), and Their Receptors in Chickens: Evidence for NPW Being a Novel Inhibitor of Pituitary GH and Prolactin Secretion.

Expressed in the zona glomerulosa and zona fasciculata-reticularis ( cells of the human adrenal cortex.
Title: G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.

characterization of a family of endogenous neuropeptide ligands for this G protein-coupled receptor
Title: Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.

distribution in central nervous system and peripheral tissues with precursor peptides
Title: Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.

The following NPBWR2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NPBWR2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29558	NM_005286.4 Latest version!	Homo sapiens neuropeptides B and W receptor 2 (NPBWR2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$139.50-$195.30 $279.00
View Old Accession Versions >>
OHu29558	NM_005286.2	Homo sapiens neuropeptides B and W receptor 2 (NPBWR2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$139.50-$195.30 $279.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NPBWR2 ( NM_005286.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005277.2 Homo sapiens neuropeptides B and W receptor 2 (NPBWR2), mRNA.

Price & Availability↑

CloneID	OHu29558
Clone ID Related Accession (Same CDS sequence)	NM_005286.4 , NM_005286.2
Accession Version	NM_005286.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	neuropeptides B/W receptor type 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121581.41. On Dec 30, 2019 this sequence version replaced NM_005286.3. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCAGGCCG CTGGGCACCC AGAGCCCCTT GACAGCAGGG GCTCCTTCTC CCTCCCCACG 
ATGGGTGCCA ACGTCTCTCA GGACAATGGC ACTGGCCACA ATGCCACCTT CTCCGAGCCA 
CTGCCGTTCC TCTATGTGCT CCTGCCCGCC GTGTACTCCG GGATCTGTGC TGTGGGGCTG 
ACTGGCAACA CGGCCGTCAT CCTTGTAATC CTAAGGGCGC CCAAGATGAA GACGGTGACC 
AACGTGTTCA TCCTGAACCT GGCCGTCGCC GACGGGCTCT TCACGCTGGT ACTGCCCGTC 
AACATCGCGG AGCACCTGCT GCAGTACTGG CCCTTCGGGG AGCTGCTCTG CAAGCTGGTG 
CTGGCCGTCG ACCACTACAA CATCTTCTCC AGCATCTACT TCCTAGCCGT GATGAGCGTG 
GACCGATACC TGGTGGTGCT GGCCACCGTG AGGTCCCGCC ACATGCCCTG GCGCACCTAC 
CGGGGGGCGA AGGTCGCCAG CCTGTGTGTC TGGCTGGGCG TCACGGTCCT GGTTCTGCCC 
TTCTTCTCTT TCGCTGGCGT CTACAGCAAC GAGCTGCAGG TCCCAAGCTG TGGGCTGAGC 
TTCCCGTGGC CCGAGCAGGT CTGGTTCAAG GCCAGCCGTG TCTACACGTT GGTCCTGGGC 
TTCGTGCTGC CCGTGTGCAC CATCTGTGTG CTCTACACAG ACCTCCTGCG CAGGCTGCGG 
GCCGTGCGGC TCCGCTCTGG AGCCAAGGCT CTAGGCAAGG CCAGGCGGAA GGTGACCGTC 
CTGGTCCTCG TCGTGCTGGC CGTGTGCCTC CTCTGCTGGA CGCCCTTCCA CCTGGCCTCT 
GTCGTGGCCC TGACCACGGA CCTGCCCCAG ACCCCACTGG TCATCAGTAT GTCCTACGTC 
ATCACCAGCC TCAGCTACGC CAACTCGTGC CTGAACCCCT TCCTCTACGC CTTTCTAGAT 
GACAACTTCC GGAAGAACTT CCGCAGCATA TTGCGGTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005277.2
CDS	294..1295
Translation	MQAAGHPEPLDSRGSFSLPTMGANVSQDNGTGHNATFSEPLPFLYVLLPAVYSGICAVGLTGNTAVILVILRAPKMKTVTNVFILNLAVADGLFTLVLPVNIAEHLLQYWPFGELLCKLVLAVDHYNIFSSIYFLAVMSVDRYLVVLATVRSRHMPWRTYRGAKVASLCVWLGVTVLVLPFFSFAGVYSNELQVPSCGLSFPWPEQVWFKASRVYTLVLGFVLPVCTICVLYTDLLRRLRAVRLRSGAKALGKARRKVTVLVLVVLAVCLLCWTPFHLASVVALTTDLPQTPLVISMSYVITSLSYANSCLNPFLYAFLDDNFRKNFRSILRC

Target ORF information:

RefSeq Version	NM_005286.4
Organism	Homo sapiens(human)
Definition	Homo sapiens neuropeptides B and W receptor 2 (NPBWR2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005286.4

ORF Insert Sequence:

ATGCAGGCCG CTGGGCACCC AGAGCCCCTT GACAGCAGGG GCTCCTTCTC CCTCCCCACG 
ATGGGTGCCA ACGTCTCTCA GGACAATGGC ACTGGCCACA ATGCCACCTT CTCCGAGCCA 
CTGCCGTTCC TCTATGTGCT CCTGCCCGCC GTGTACTCCG GGATCTGTGC TGTGGGGCTG 
ACTGGCAACA CGGCCGTCAT CCTTGTAATC CTAAGGGCGC CCAAGATGAA GACGGTGACC 
AACGTGTTCA TCCTGAACCT GGCCGTCGCC GACGGGCTCT TCACGCTGGT ACTGCCCGTC 
AACATCGCGG AGCACCTGCT GCAGTACTGG CCCTTCGGGG AGCTGCTCTG CAAGCTGGTG 
CTGGCCGTCG ACCACTACAA CATCTTCTCC AGCATCTACT TCCTAGCCGT GATGAGCGTG 
GACCGATACC TGGTGGTGCT GGCCACCGTG AGGTCCCGCC ACATGCCCTG GCGCACCTAC 
CGGGGGGCGA AGGTCGCCAG CCTGTGTGTC TGGCTGGGCG TCACGGTCCT GGTTCTGCCC 
TTCTTCTCTT TCGCTGGCGT CTACAGCAAC GAGCTGCAGG TCCCAAGCTG TGGGCTGAGC 
TTCCCGTGGC CCGAGCAGGT CTGGTTCAAG GCCAGCCGTG TCTACACGTT GGTCCTGGGC 
TTCGTGCTGC CCGTGTGCAC CATCTGTGTG CTCTACACAG ACCTCCTGCG CAGGCTGCGG 
GCCGTGCGGC TCCGCTCTGG AGCCAAGGCT CTAGGCAAGG CCAGGCGGAA GGTGACCGTC 
CTGGTCCTCG TCGTGCTGGC CGTGTGCCTC CTCTGCTGGA CGCCCTTCCA CCTGGCCTCT 
GTCGTGGCCC TGACCACGGA CCTGCCCCAG ACCCCACTGG TCATCAGTAT GTCCTACGTC 
ATCACCAGCC TCAGCTACGC CAACTCGTGC CTGAACCCCT TCCTCTACGC CTTTCTAGAT 
GACAACTTCC GGAAGAACTT CCGCAGCATA TTGCGGTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NPBWR2 ( NM_005286.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005277.2 Homo sapiens neuropeptides B and W receptor 2 (NPBWR2), mRNA.

Price & Availability↑

CloneID	OHu29558
Clone ID Related Accession (Same CDS sequence)	NM_005286.4 , NM_005286.2
Accession Version	NM_005286.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	neuropeptides B/W receptor type 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC067481.1 and BC067482.1. On May 13, 2003 this sequence version replaced NM_005286.1. ##Evidence-Data-START## Transcript is intronless :: BC067483.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCAGGCCG CTGGGCACCC AGAGCCCCTT GACAGCAGGG GCTCCTTCTC CCTCCCCACG 
ATGGGTGCCA ACGTCTCTCA GGACAATGGC ACTGGCCACA ATGCCACCTT CTCCGAGCCA 
CTGCCGTTCC TCTATGTGCT CCTGCCCGCC GTGTACTCCG GGATCTGTGC TGTGGGGCTG 
ACTGGCAACA CGGCCGTCAT CCTTGTAATC CTAAGGGCGC CCAAGATGAA GACGGTGACC 
AACGTGTTCA TCCTGAACCT GGCCGTCGCC GACGGGCTCT TCACGCTGGT ACTGCCCGTC 
AACATCGCGG AGCACCTGCT GCAGTACTGG CCCTTCGGGG AGCTGCTCTG CAAGCTGGTG 
CTGGCCGTCG ACCACTACAA CATCTTCTCC AGCATCTACT TCCTAGCCGT GATGAGCGTG 
GACCGATACC TGGTGGTGCT GGCCACCGTG AGGTCCCGCC ACATGCCCTG GCGCACCTAC 
CGGGGGGCGA AGGTCGCCAG CCTGTGTGTC TGGCTGGGCG TCACGGTCCT GGTTCTGCCC 
TTCTTCTCTT TCGCTGGCGT CTACAGCAAC GAGCTGCAGG TCCCAAGCTG TGGGCTGAGC 
TTCCCGTGGC CCGAGCAGGT CTGGTTCAAG GCCAGCCGTG TCTACACGTT GGTCCTGGGC 
TTCGTGCTGC CCGTGTGCAC CATCTGTGTG CTCTACACAG ACCTCCTGCG CAGGCTGCGG 
GCCGTGCGGC TCCGCTCTGG AGCCAAGGCT CTAGGCAAGG CCAGGCGGAA GGTGACCGTC 
CTGGTCCTCG TCGTGCTGGC CGTGTGCCTC CTCTGCTGGA CGCCCTTCCA CCTGGCCTCT 
GTCGTGGCCC TGACCACGGA CCTGCCCCAG ACCCCACTGG TCATCAGTAT GTCCTACGTC 
ATCACCAGCC TCAGCTACGC CAACTCGTGC CTGAACCCCT TCCTCTACGC CTTTCTAGAT 
GACAACTTCC GGAAGAACTT CCGCAGCATA TTGCGGTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005277.2
CDS	1..1002
Translation	MQAAGHPEPLDSRGSFSLPTMGANVSQDNGTGHNATFSEPLPFLYVLLPAVYSGICAVGLTGNTAVILVILRAPKMKTVTNVFILNLAVADGLFTLVLPVNIAEHLLQYWPFGELLCKLVLAVDHYNIFSSIYFLAVMSVDRYLVVLATVRSRHMPWRTYRGAKVASLCVWLGVTVLVLPFFSFAGVYSNELQVPSCGLSFPWPEQVWFKASRVYTLVLGFVLPVCTICVLYTDLLRRLRAVRLRSGAKALGKARRKVTVLVLVVLAVCLLCWTPFHLASVVALTTDLPQTPLVISMSYVITSLSYANSCLNPFLYAFLDDNFRKNFRSILRC

Target ORF information:

RefSeq Version	NM_005286.2
Organism	Homo sapiens(human)
Definition	Homo sapiens neuropeptides B and W receptor 2 (NPBWR2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005286.2

ORF Insert Sequence:

ATGCAGGCCG CTGGGCACCC AGAGCCCCTT GACAGCAGGG GCTCCTTCTC CCTCCCCACG 
ATGGGTGCCA ACGTCTCTCA GGACAATGGC ACTGGCCACA ATGCCACCTT CTCCGAGCCA 
CTGCCGTTCC TCTATGTGCT CCTGCCCGCC GTGTACTCCG GGATCTGTGC TGTGGGGCTG 
ACTGGCAACA CGGCCGTCAT CCTTGTAATC CTAAGGGCGC CCAAGATGAA GACGGTGACC 
AACGTGTTCA TCCTGAACCT GGCCGTCGCC GACGGGCTCT TCACGCTGGT ACTGCCCGTC 
AACATCGCGG AGCACCTGCT GCAGTACTGG CCCTTCGGGG AGCTGCTCTG CAAGCTGGTG 
CTGGCCGTCG ACCACTACAA CATCTTCTCC AGCATCTACT TCCTAGCCGT GATGAGCGTG 
GACCGATACC TGGTGGTGCT GGCCACCGTG AGGTCCCGCC ACATGCCCTG GCGCACCTAC 
CGGGGGGCGA AGGTCGCCAG CCTGTGTGTC TGGCTGGGCG TCACGGTCCT GGTTCTGCCC 
TTCTTCTCTT TCGCTGGCGT CTACAGCAAC GAGCTGCAGG TCCCAAGCTG TGGGCTGAGC 
TTCCCGTGGC CCGAGCAGGT CTGGTTCAAG GCCAGCCGTG TCTACACGTT GGTCCTGGGC 
TTCGTGCTGC CCGTGTGCAC CATCTGTGTG CTCTACACAG ACCTCCTGCG CAGGCTGCGG 
GCCGTGCGGC TCCGCTCTGG AGCCAAGGCT CTAGGCAAGG CCAGGCGGAA GGTGACCGTC 
CTGGTCCTCG TCGTGCTGGC CGTGTGCCTC CTCTGCTGGA CGCCCTTCCA CCTGGCCTCT 
GTCGTGGCCC TGACCACGGA CCTGCCCCAG ACCCCACTGG TCATCAGTAT GTCCTACGTC 
ATCACCAGCC TCAGCTACGC CAACTCGTGC CTGAACCCCT TCCTCTACGC CTTTCTAGAT 
GACAACTTCC GGAAGAACTT CCGCAGCATA TTGCGGTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of Neuropeptide B (NPB), Neuropeptide W (NPW), and Their Receptors in Chickens: Evidence for NPW Being a Novel Inhibitor of Pituitary GH and Prolactin Secretion.
Endocrinology157(9)3562-76(2016 Sep)
Bu G,Lin D,Cui L,Huang L,Lv C,Huang S,Wan Y,Fang C,Li J,Wang Y

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
Molecular biotechnology39(3)239-64(2008 Jul)
Luttrell LM

Dissociation of heterotrimeric g proteins in cells.
Science signaling1(25)re5(2008 Jun)
Lambert NA

G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.
The Journal of clinical endocrinology and metabolism90(6)3466-71(2005 Jun)
Mazzocchi G,Rebuffat P,Ziolkowska A,Rossi GP,Malendowicz LK,Nussdorfer GG

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.
Proceedings of the National Academy of Sciences of the United States of America100(10)6251-6(2003 May)
Tanaka H,Yoshida T,Miyamoto N,Motoike T,Kurosu H,Shibata K,Yamanaka A,Williams SC,Richardson JA,Tsujino N,Garry MG,Lerner MR,King DS,O'Dowd BF,Sakurai T,Yanagisawa M

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NPBWR2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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