IFNL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNL2
Entrez Gene ID	282616
Full Name	interferon lambda 2
Synonyms	IL-28A,IL28A
General protein information	Preferred Names interferon lambda 2 Names interferon lambda-2 IFN-lambda-2 cytokine Zcyto20 interleukin 28A (interferon, lambda 2) interleukin-28A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008].
Disorder MIM:	607401

mRNA and Protein(s)

mRNA	Protein	Name
XM_011526756.1	XP_011525058.1	interferon lambda-2 isoform X1
NM_172138.1	NP_742150.1	interferon lambda-2
NM_172138.2	NP_742150.1	interferon lambda-2 precursor

Pathways from BioSystems

Homologies

	IL28B	XP_002801274.1
Homo sapiens (human)	IFNL2	NP_742150.1

Gene Ontology
Bibliography

Related articles in PubMed

Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation.
Chaudhary V, Zhang S, Yuen KS, Li C, Lui PY, Fung SY, Wang PH, Chan CP, Li D, Kok KH, Liang M, Jin DY
The Journal of general virology96(11)3204-11(2015 Nov)

Guarding the frontiers: the biology of type III interferons.
Wack A, Terczy?ska-Dyla E, Hartmann R
Nature immunology16(8)802-9(2015 Aug)

Impact and regulation of lambda interferon response in human metapneumovirus infection.
Ba?os-Lara Mdel R, Harvey L, Mendoza A, Simms D, Chouljenko VN, Wakamatsu N, Kousoulas KG, Guerrero-Plata A
Journal of virology89(1)730-42(2015 Jan)

Interleukin-28A promotes IFN-? production by peripheral blood mononuclear cells from patients with Beh?et's disease.
Li B, Xie C, Lin X, Su SB
Cellular immunology290(1)116-9(2014 Jul)

Transcriptional regulation of IFN-? genes in hepatitis C virus-infected hepatocytes via IRF-3?IRF-7?NF-?B complex.
Lee HC, Narayanan S, Park SJ, Seong SY, Hahn YS
The Journal of biological chemistry289(8)5310-9(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NS of severe fever with thrombocytopenia syndrome virus inhibited the activity of IFN-alpha1, IFN-beta, IFN-lambda1 and IFN-lambda2 through inhibition of STAT1 phosphorylation.
Title: Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation.

Studies indicate that the type III interferons (IFNs) or IFN-lambdas consists of four members: IFN-lambda1 (IL-29), IFN-lambda2 (IL28A), IFN-lambda3 (IL-28B) and IFN-lambda4.
Title: Guarding the frontiers: the biology of type III interferons.

These results show that type III interferons (IFN-lambdas) play a critical protective role in human metapneumovirus infection.
Title: Impact and regulation of lambda interferon response in human metapneumovirus infection.

this study provides evidence for potential IL-28A participation in Behcet's diseaseand its value as a therapeutic agent.
Title: Interleukin-28A promotes IFN-? production by peripheral blood mononuclear cells from patients with Beh?et's disease.

Interferon regulatory factor (IRF)-3 and -7 are the key transcriptional factors for the induction of IL-28A and IL-28B genes, whereas NF-kappaB is an additional requirement for the induction of the IL-29 gene.
Title: Transcriptional regulation of IFN-? genes in hepatitis C virus-infected hepatocytes via IRF-3?IRF-7?NF-?B complex.

The following IFNL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17422	NM_172138.2 Latest version!	Homo sapiens interferon lambda 2 (IFNL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu17422	XM_011526756.1 Latest version!	Homo sapiens interferon, lambda 2 (IFNL2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu17422	NM_172138.1	Homo sapiens interferon lambda 2 (IFNL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNL2 ( NM_172138.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_742150.1 Homo sapiens interferon lambda 2 (IFNL2), mRNA.

Price & Availability↑

CloneID	OHu17422
Clone ID Related Accession (Same CDS sequence)	XM_011526756.1 , NM_172138.1 , NM_172138.2
Accession Version	NM_172138.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	interferon lambda-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY129148.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY129148.1, DQ126337.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAAACTAG ACATGACTGG GGACTGCACG CCAGTGCTGG TGCTGATGGC CGCAGTGCTG 
ACCGTGACTG GAGCAGTTCC TGTCGCCAGG CTCCACGGGG CTCTCCCGGA TGCAAGGGGC 
TGCCACATAG CCCAGTTCAA GTCCCTGTCT CCACAGGAGC TGCAGGCCTT TAAGAGGGCC 
AAAGATGCCT TAGAAGAGTC GCTTCTGCTG AAGGACTGCA GGTGCCACTC CCGCCTCTTC 
CCCAGGACCT GGGACCTGAG GCAGCTGCAG GTGAGGGAGC GCCCCATGGC TTTGGAGGCT 
GAGCTGGCCC TGACGCTGAA GGTTCTGGAG GCCACCGCTG ACACTGACCC AGCCCTGGTG 
GACGTCTTGG ACCAGCCCCT TCACACCCTG CACCATATCC TCTCCCAGTT CCGGGCCTGT 
ATCCAGCCTC AGCCCACGGC AGGGCCCAGG ACCCGGGGCC GCCTCCACCA TTGGCTGTAC 
CGGCTCCAGG AGGCCCCAAA AAAGGAGTCC CCTGGCTGCC TCGAGGCCTC TGTCACCTTC 
AACCTCTTCC GCCTCCTCAC GCGAGACCTG AATTGTGTTG CCAGTGGGGA CCTGTGTGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_742150.1
CDS	53..655
Translation	MKLDMTGDCTPVLVLMAAVLTVTGAVPVARLHGALPDARGCHIAQFKSLSPQELQAFKRAKDALEESLLLKDCRCHSRLFPRTWDLRQLQVRERPMALEAELALTLKVLEATADTDPALVDVLDQPLHTLHHILSQFRACIQPQPTAGPRTRGRLHHWLYRLQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV

Target ORF information:

RefSeq Version	NM_172138.1
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon lambda 2 (IFNL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172138.1

ORF Insert Sequence:

ATGAAACTAG ACATGACTGG GGACTGCACG CCAGTGCTGG TGCTGATGGC CGCAGTGCTG 
ACCGTGACTG GAGCAGTTCC TGTCGCCAGG CTCCACGGGG CTCTCCCGGA TGCAAGGGGC 
TGCCACATAG CCCAGTTCAA GTCCCTGTCT CCACAGGAGC TGCAGGCCTT TAAGAGGGCC 
AAAGATGCCT TAGAAGAGTC GCTTCTGCTG AAGGACTGCA GGTGCCACTC CCGCCTCTTC 
CCCAGGACCT GGGACCTGAG GCAGCTGCAG GTGAGGGAGC GCCCCATGGC TTTGGAGGCT 
GAGCTGGCCC TGACGCTGAA GGTTCTGGAG GCCACCGCTG ACACTGACCC AGCCCTGGTG 
GACGTCTTGG ACCAGCCCCT TCACACCCTG CACCATATCC TCTCCCAGTT CCGGGCCTGT 
ATCCAGCCTC AGCCCACGGC AGGGCCCAGG ACCCGGGGCC GCCTCCACCA TTGGCTGTAC 
CGGCTCCAGG AGGCCCCAAA AAAGGAGTCC CCTGGCTGCC TCGAGGCCTC TGTCACCTTC 
AACCTCTTCC GCCTCCTCAC GCGAGACCTG AATTGTGTTG CCAGTGGGGA CCTGTGTGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IFNL2 ( NM_172138.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_742150.1 Homo sapiens interferon lambda 2 (IFNL2), mRNA.

Price & Availability↑

CloneID	OHu17422
Clone ID Related Accession (Same CDS sequence)	XM_011526756.1 , NM_172138.1 , NM_172138.2
Accession Version	NM_172138.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-29
Organism	Homo sapiens(human)
Product	interferon lambda-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC011445.6, AY129148.1 and AA774195.1. On Aug 7, 2019 this sequence version replaced NM_172138.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ126337.1, AY129148.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAAACTAG ACATGACTGG GGACTGCACG CCAGTGCTGG TGCTGATGGC CGCAGTGCTG 
ACCGTGACTG GAGCAGTTCC TGTCGCCAGG CTCCACGGGG CTCTCCCGGA TGCAAGGGGC 
TGCCACATAG CCCAGTTCAA GTCCCTGTCT CCACAGGAGC TGCAGGCCTT TAAGAGGGCC 
AAAGATGCCT TAGAAGAGTC GCTTCTGCTG AAGGACTGCA GGTGCCACTC CCGCCTCTTC 
CCCAGGACCT GGGACCTGAG GCAGCTGCAG GTGAGGGAGC GCCCCATGGC TTTGGAGGCT 
GAGCTGGCCC TGACGCTGAA GGTTCTGGAG GCCACCGCTG ACACTGACCC AGCCCTGGTG 
GACGTCTTGG ACCAGCCCCT TCACACCCTG CACCATATCC TCTCCCAGTT CCGGGCCTGT 
ATCCAGCCTC AGCCCACGGC AGGGCCCAGG ACCCGGGGCC GCCTCCACCA TTGGCTGTAC 
CGGCTCCAGG AGGCCCCAAA AAAGGAGTCC CCTGGCTGCC TCGAGGCCTC TGTCACCTTC 
AACCTCTTCC GCCTCCTCAC GCGAGACCTG AATTGTGTTG CCAGTGGGGA CCTGTGTGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_742150.1
CDS	174..776
Translation	MKLDMTGDCTPVLVLMAAVLTVTGAVPVARLHGALPDARGCHIAQFKSLSPQELQAFKRAKDALEESLLLKDCRCHSRLFPRTWDLRQLQVRERPMALEAELALTLKVLEATADTDPALVDVLDQPLHTLHHILSQFRACIQPQPTAGPRTRGRLHHWLYRLQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV

Target ORF information:

RefSeq Version	NM_172138.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon lambda 2 (IFNL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172138.2

ORF Insert Sequence:

ATGAAACTAG ACATGACTGG GGACTGCACG CCAGTGCTGG TGCTGATGGC CGCAGTGCTG 
ACCGTGACTG GAGCAGTTCC TGTCGCCAGG CTCCACGGGG CTCTCCCGGA TGCAAGGGGC 
TGCCACATAG CCCAGTTCAA GTCCCTGTCT CCACAGGAGC TGCAGGCCTT TAAGAGGGCC 
AAAGATGCCT TAGAAGAGTC GCTTCTGCTG AAGGACTGCA GGTGCCACTC CCGCCTCTTC 
CCCAGGACCT GGGACCTGAG GCAGCTGCAG GTGAGGGAGC GCCCCATGGC TTTGGAGGCT 
GAGCTGGCCC TGACGCTGAA GGTTCTGGAG GCCACCGCTG ACACTGACCC AGCCCTGGTG 
GACGTCTTGG ACCAGCCCCT TCACACCCTG CACCATATCC TCTCCCAGTT CCGGGCCTGT 
ATCCAGCCTC AGCCCACGGC AGGGCCCAGG ACCCGGGGCC GCCTCCACCA TTGGCTGTAC 
CGGCTCCAGG AGGCCCCAAA AAAGGAGTCC CCTGGCTGCC TCGAGGCCTC TGTCACCTTC 
AACCTCTTCC GCCTCCTCAC GCGAGACCTG AATTGTGTTG CCAGTGGGGA CCTGTGTGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IFNL2 ( XM_011526756.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525058.1 Homo sapiens interferon, lambda 2 (IFNL2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu17422
Clone ID Related Accession (Same CDS sequence)	XM_011526756.1 , NM_172138.1 , NM_172138.2
Accession Version	XM_011526756.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	interferon lambda-2 isoform X1
Comment

ATGAAACTAG ACATGACTGG GGACTGCACG CCAGTGCTGG TGCTGATGGC CGCAGTGCTG 
ACCGTGACTG GAGCAGTTCC TGTCGCCAGG CTCCACGGGG CTCTCCCGGA TGCAAGGGGC 
TGCCACATAG CCCAGTTCAA GTCCCTGTCT CCACAGGAGC TGCAGGCCTT TAAGAGGGCC 
AAAGATGCCT TAGAAGAGTC GCTTCTGCTG AAGGACTGCA GGTGCCACTC CCGCCTCTTC 
CCCAGGACCT GGGACCTGAG GCAGCTGCAG GTGAGGGAGC GCCCCATGGC TTTGGAGGCT 
GAGCTGGCCC TGACGCTGAA GGTTCTGGAG GCCACCGCTG ACACTGACCC AGCCCTGGTG 
GACGTCTTGG ACCAGCCCCT TCACACCCTG CACCATATCC TCTCCCAGTT CCGGGCCTGT 
ATCCAGCCTC AGCCCACGGC AGGGCCCAGG ACCCGGGGCC GCCTCCACCA TTGGCTGTAC 
CGGCTCCAGG AGGCCCCAAA AAAGGAGTCC CCTGGCTGCC TCGAGGCCTC TGTCACCTTC 
AACCTCTTCC GCCTCCTCAC GCGAGACCTG AATTGTGTTG CCAGTGGGGA CCTGTGTGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525058.1
Translation	MKLDMTGDCTPVLVLMAAVLTVTGAVPVARLHGALPDARGCHIAQFKSLSPQELQAFKRAKDALEESLLLKDCRCHSRLFPRTWDLRQLQVRERPMALEAELALTLKVLEATADTDPALVDVLDQPLHTLHHILSQFRACIQPQPTAGPRTRGRLHHWLYRLQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV

Target ORF information:

RefSeq Version	XM_011526756.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens interferon, lambda 2 (IFNL2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526756.1

ORF Insert Sequence:

ATGAAACTAG ACATGACTGG GGACTGCACG CCAGTGCTGG TGCTGATGGC CGCAGTGCTG 
ACCGTGACTG GAGCAGTTCC TGTCGCCAGG CTCCACGGGG CTCTCCCGGA TGCAAGGGGC 
TGCCACATAG CCCAGTTCAA GTCCCTGTCT CCACAGGAGC TGCAGGCCTT TAAGAGGGCC 
AAAGATGCCT TAGAAGAGTC GCTTCTGCTG AAGGACTGCA GGTGCCACTC CCGCCTCTTC 
CCCAGGACCT GGGACCTGAG GCAGCTGCAG GTGAGGGAGC GCCCCATGGC TTTGGAGGCT 
GAGCTGGCCC TGACGCTGAA GGTTCTGGAG GCCACCGCTG ACACTGACCC AGCCCTGGTG 
GACGTCTTGG ACCAGCCCCT TCACACCCTG CACCATATCC TCTCCCAGTT CCGGGCCTGT 
ATCCAGCCTC AGCCCACGGC AGGGCCCAGG ACCCGGGGCC GCCTCCACCA TTGGCTGTAC 
CGGCTCCAGG AGGCCCCAAA AAAGGAGTCC CCTGGCTGCC TCGAGGCCTC TGTCACCTTC 
AACCTCTTCC GCCTCCTCAC GCGAGACCTG AATTGTGTTG CCAGTGGGGA CCTGTGTGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation.
The Journal of general virology96(11)3204-11(2015 Nov)
Chaudhary V,Zhang S,Yuen KS,Li C,Lui PY,Fung SY,Wang PH,Chan CP,Li D,Kok KH,Liang M,Jin DY

Guarding the frontiers: the biology of type III interferons.
Nature immunology16(8)802-9(2015 Aug)
Wack A,Terczy?ska-Dyla E,Hartmann R

Impact and regulation of lambda interferon response in human metapneumovirus infection.
Journal of virology89(1)730-42(2015 Jan)
Ba?os-Lara Mdel R,Harvey L,Mendoza A,Simms D,Chouljenko VN,Wakamatsu N,Kousoulas KG,Guerrero-Plata A

Interleukin-28A promotes IFN-? production by peripheral blood mononuclear cells from patients with Beh?et's disease.
Cellular immunology290(1)116-9(2014 Jul)
Li B,Xie C,Lin X,Su SB

Transcriptional regulation of IFN-? genes in hepatitis C virus-infected hepatocytes via IRF-3?IRF-7?NF-?B complex.
The Journal of biological chemistry289(8)5310-9(2014 Feb)
Lee HC,Narayanan S,Park SJ,Seong SY,Hahn YS

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IFNL2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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