GP5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GP5
Entrez Gene ID	2814
Full Name	glycoprotein V platelet
Synonyms	CD42d,GPV
General protein information	Preferred Names glycoprotein V platelet Names platelet glycoprotein V glycoprotein 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q29
Summary	Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010].
Disorder MIM:	173511

mRNA and Protein(s)

mRNA	Protein	Name
NM_004488.2	NP_004479.1	platelet glycoprotein V precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GP5	XP_005201616.1
Mus musculus (house mouse)	Gp5	NP_032174.2
Xenopus tropicalis (tropical clawed frog)	gp5	XP_002937891.1
Pan troglodytes (chimpanzee)	GP5	XP_001162759.1
	GP5	XP_001096206.1
Homo sapiens (human)	GP5	NP_004479.1
Gallus gallus (chicken)	LOC100857508	XP_004943385.1
Danio rerio (zebrafish)	LOC101884430	XP_005161800.1

Gene Ontology
Bibliography

Related articles in PubMed

Bernard-Soulier syndrome: an update.
Andrews RK, Berndt MC
Seminars in thrombosis and hemostasis39(6)656-62(2013 Sep)

Delineating the roles of the GPIIb/IIIa and GP-Ib-IX-V platelet receptors in mediating platelet adhesion to adsorbed fibrinogen and albumin.
Sivaraman B, Latour RA
Biomaterials32(23)5365-70(2011 Aug)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

The platelet glycoprotein Ib-IX-V complex anchors lipid rafts to the membrane skeleton: implications for activation-dependent cytoskeletal translocation of signaling molecules.
Munday AD, Gaus K, L?pez JA
Journal of thrombosis and haemostasis : JTH8(1)163-72(2010 Jan)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Studies indicate that platelets from Bernard-Soulier syndrome (BSS) are defective in glycoprotein (GP)Ib-IX-V, a platelet-specific adhesion-signaling complex, composed of GPIbalpha disulfide linked to GPIbbeta, and noncovalently associated with GPIX and GPV.
Title: Bernard-Soulier syndrome: an update.

GPIIb/IIIa is the primary receptor set involved in platelet adhesion to adsorbed fibrinogen and serum albumin irrespective of their degree of adsorption-induced unfolding, while the GPIb-IX-V receptor complex plays an insignificant role.
Title: Delineating the roles of the GPIIb/IIIa and GP-Ib-IX-V platelet receptors in mediating platelet adhesion to adsorbed fibrinogen and albumin.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following GP5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GP5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu13449	NM_004488.2 Latest version!	Homo sapiens glycoprotein V platelet (GP5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GP5 ( NM_004488.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004479.1 Homo sapiens glycoprotein V platelet (GP5), mRNA.

Price & Availability↑

CloneID	OHu13449
Clone ID Related Accession (Same CDS sequence)	NM_004488.2
Accession Version	NM_004488.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1683bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	platelet glycoprotein V precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC125362.6. On Jul 20, 2006 this sequence version replaced NM_004488.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: L11238.1, BM145911.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2152798, SAMN03465405 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCTGAGGG GGACTCTACT GTGCGCGGTG CTCGGGCTTC TGCGCGCCCA GCCCTTCCCC 
TGTCCGCCAG CTTGCAAGTG TGTCTTCCGG GACGCCGCGC AGTGCTCGGG GGGCGACGTG 
GCGCGCATCT CCGCGCTAGG CCTGCCCACC AACCTCACGC ACATCCTGCT CTTCGGAATG 
GGCCGCGGCG TCCTGCAGAG CCAGAGCTTC AGCGGCATGA CCGTCCTGCA GCGCCTCATG 
ATCTCCGACA GCCACATTTC CGCCGTTGCC CCCGGCACCT TCAGTGACCT GATAAAACTG 
AAAACCCTGA GGCTGTCGCG CAACAAAATC ACGCATCTTC CAGGTGCGCT GCTGGATAAG 
ATGGTGCTCC TGGAGCAGTT GTTTTTGGAC CACAATGCGC TAAGGGGCAT TGACCAAAAC 
ATGTTTCAGA AACTGGTTAA CCTGCAGGAG CTCGCTCTGA ACCAGAATCA GCTCGATTTC 
CTTCCTGCCA GTCTCTTCAC GAATCTGGAG AACCTGAAGT TGTTGGATTT ATCGGGAAAC 
AACCTGACCC ACCTGCCCAA GGGGTTGCTT GGAGCACAGG CTAAGCTCGA GAGACTTCTG 
CTCCACTCGA ACCGCCTTGT GTCTCTGGAT TCGGGGCTGT TGAACAGCCT GGGCGCCCTG 
ACGGAGCTGC AGTTCCACCG AAATCACATC CGTTCCATCG CACCCGGGGC CTTCGACCGG 
CTCCCAAACC TCAGTTCTTT GACGCTTTCG AGAAACCACC TTGCGTTTCT CCCCTCTGCG 
CTCTTTCTTC ATTCGCACAA TCTGACTCTG TTGACTCTGT TCGAGAACCC GCTGGCAGAG 
CTCCCGGGGG TGCTCTTCGG GGAGATGGGG GGCCTGCAGG AGCTGTGGCT GAACCGCACC 
CAGCTGCGCA CCCTGCCCGC CGCCGCCTTC CGCAACCTGA GCCGCCTGCG GTACTTAGGG 
GTGACTCTGA GCCCGCGGCT GAGCGCGCTT CCGCAGGGCG CCTTCCAGGG CCTTGGCGAG 
CTCCAGGTGC TCGCCCTGCA CTCCAACGGC CTGACCGCCC TCCCCGACGG CTTGCTGCGC 
GGCCTCGGCA AGCTGCGCCA GGTGTCCCTG CGCCGCAACA GGCTGCGCGC CCTGCCCCGT 
GCCCTCTTCC GCAATCTCAG CAGCCTGGAG AGCGTCCAGC TCGACCACAA CCAGCTGGAG 
ACCCTGCCTG GCGACGTGTT TGGGGCTCTG CCCCGGCTGA CGGAGGTCCT GTTGGGGCAC 
AACTCCTGGC GCTGCGACTG TGGCCTGGGG CCCTTCCTGG GGTGGCTGCG GCAGCACCTA 
GGCCTCGTGG GCGGGGAAGA GCCCCCACGG TGCGCAGGCC CTGGGGCGCA CGCCGGCCTG 
CCGCTCTGGG CCCTGCCGGG GGGTGACGCG GAGTGCCCGG GCCCCCGGGG CCCGCCTCCC 
CGCCCCGCTG CGGACAGCTC CTCGGAAGCC CCTGTCCACC CAGCCTTGGC TCCCAACAGC 
TCAGAACCCT GGGTGTGGGC CCAGCCGGTG ACCACGGGCA AAGGTCAAGA TCATAGTCCG 
TTCTGGGGGT TTTATTTTCT GCTTTTAGCT GTTCAGGCCA TGATCACCGT GATCATCGTG 
TTTGCTATGA TTAAAATTGG CCAACTCTTT CGAAAATTAA TCAGAGAGAG AGCCCTTGGG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004479.1
CDS	32..1714
Translation	MLRGTLLCAVLGLLRAQPFPCPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGPRGPPPRPAADSSSEAPVHPALAPNSSEPWVWAQPVTTGKGQDHSPFWGFYFLLLAVQAMITVIIVFAMIKIGQLFRKLIRERALG

Target ORF information:

RefSeq Version	NM_004488.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glycoprotein V platelet (GP5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004488.2

ORF Insert Sequence:

ATGCTGAGGG GGACTCTACT GTGCGCGGTG CTCGGGCTTC TGCGCGCCCA GCCCTTCCCC 
TGTCCGCCAG CTTGCAAGTG TGTCTTCCGG GACGCCGCGC AGTGCTCGGG GGGCGACGTG 
GCGCGCATCT CCGCGCTAGG CCTGCCCACC AACCTCACGC ACATCCTGCT CTTCGGAATG 
GGCCGCGGCG TCCTGCAGAG CCAGAGCTTC AGCGGCATGA CCGTCCTGCA GCGCCTCATG 
ATCTCCGACA GCCACATTTC CGCCGTTGCC CCCGGCACCT TCAGTGACCT GATAAAACTG 
AAAACCCTGA GGCTGTCGCG CAACAAAATC ACGCATCTTC CAGGTGCGCT GCTGGATAAG 
ATGGTGCTCC TGGAGCAGTT GTTTTTGGAC CACAATGCGC TAAGGGGCAT TGACCAAAAC 
ATGTTTCAGA AACTGGTTAA CCTGCAGGAG CTCGCTCTGA ACCAGAATCA GCTCGATTTC 
CTTCCTGCCA GTCTCTTCAC GAATCTGGAG AACCTGAAGT TGTTGGATTT ATCGGGAAAC 
AACCTGACCC ACCTGCCCAA GGGGTTGCTT GGAGCACAGG CTAAGCTCGA GAGACTTCTG 
CTCCACTCGA ACCGCCTTGT GTCTCTGGAT TCGGGGCTGT TGAACAGCCT GGGCGCCCTG 
ACGGAGCTGC AGTTCCACCG AAATCACATC CGTTCCATCG CACCCGGGGC CTTCGACCGG 
CTCCCAAACC TCAGTTCTTT GACGCTTTCG AGAAACCACC TTGCGTTTCT CCCCTCTGCG 
CTCTTTCTTC ATTCGCACAA TCTGACTCTG TTGACTCTGT TCGAGAACCC GCTGGCAGAG 
CTCCCGGGGG TGCTCTTCGG GGAGATGGGG GGCCTGCAGG AGCTGTGGCT GAACCGCACC 
CAGCTGCGCA CCCTGCCCGC CGCCGCCTTC CGCAACCTGA GCCGCCTGCG GTACTTAGGG 
GTGACTCTGA GCCCGCGGCT GAGCGCGCTT CCGCAGGGCG CCTTCCAGGG CCTTGGCGAG 
CTCCAGGTGC TCGCCCTGCA CTCCAACGGC CTGACCGCCC TCCCCGACGG CTTGCTGCGC 
GGCCTCGGCA AGCTGCGCCA GGTGTCCCTG CGCCGCAACA GGCTGCGCGC CCTGCCCCGT 
GCCCTCTTCC GCAATCTCAG CAGCCTGGAG AGCGTCCAGC TCGACCACAA CCAGCTGGAG 
ACCCTGCCTG GCGACGTGTT TGGGGCTCTG CCCCGGCTGA CGGAGGTCCT GTTGGGGCAC 
AACTCCTGGC GCTGCGACTG TGGCCTGGGG CCCTTCCTGG GGTGGCTGCG GCAGCACCTA 
GGCCTCGTGG GCGGGGAAGA GCCCCCACGG TGCGCAGGCC CTGGGGCGCA CGCCGGCCTG 
CCGCTCTGGG CCCTGCCGGG GGGTGACGCG GAGTGCCCGG GCCCCCGGGG CCCGCCTCCC 
CGCCCCGCTG CGGACAGCTC CTCGGAAGCC CCTGTCCACC CAGCCTTGGC TCCCAACAGC 
TCAGAACCCT GGGTGTGGGC CCAGCCGGTG ACCACGGGCA AAGGTCAAGA TCATAGTCCG 
TTCTGGGGGT TTTATTTTCT GCTTTTAGCT GTTCAGGCCA TGATCACCGT GATCATCGTG 
TTTGCTATGA TTAAAATTGG CCAACTCTTT CGAAAATTAA TCAGAGAGAG AGCCCTTGGG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bernard-Soulier syndrome: an update.
Seminars in thrombosis and hemostasis39(6)656-62(2013 Sep)
Andrews RK,Berndt MC

Delineating the roles of the GPIIb/IIIa and GP-Ib-IX-V platelet receptors in mediating platelet adhesion to adsorbed fibrinogen and albumin.
Biomaterials32(23)5365-70(2011 Aug)
Sivaraman B,Latour RA

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

The platelet glycoprotein Ib-IX-V complex anchors lipid rafts to the membrane skeleton: implications for activation-dependent cytoskeletal translocation of signaling molecules.
Journal of thrombosis and haemostasis : JTH8(1)163-72(2010 Jan)
Munday AD,Gaus K,L?pez JA

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

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GP5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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