GP1BA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GP1BA
Entrez Gene ID	2811
Full Name	glycoprotein Ib platelet alpha subunit
Synonyms	BDPLT1,BDPLT3,BSS,CD42B,CD42b-alpha,DBPLT3,GP1B,GPIbA,GPIbalpha,VWDP
General protein information	Preferred Names glycoprotein Ib platelet alpha subunit Names platelet glycoprotein Ib alpha chain GP-Ib alpha antigen CD42b-alpha glycoprotein Ib (platelet), alpha polypeptide mutant platelet membrane glycoprotein Ib-alpha platelet membrane glycoprotein 1b-alpha subunit platelet membrane glycoprotein Ib-alpha
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.2
Summary	Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013].
Disorder MIM:	606672
Disorder Html:	Bernard-Soulier syndrome, type A1 (recessive), 231200 (3); {Nonarteritic anterior ischemic optic neuropathy, susceptibility to}, 258660 (3); Bernard-Soulier syndrome, type A2 (dominant), 153670 (3); von Willebrand disease, platelet-type, 177820 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000173.6	NP_000164.5	platelet glycoprotein Ib alpha chain precursor
NM_000173.7	NP_000164.5	platelet glycoprotein Ib alpha chain precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GP1BA	NP_000164.5
Rattus norvegicus (Norway rat)	Gp1ba	NP_001103124.1
Pan troglodytes (chimpanzee)	GP1BA	XP_523557.4
	LOC721584	XP_001117767.2
Mus musculus (house mouse)	Gp1ba	NP_034456.2

Gene Ontology
Bibliography

Related articles in PubMed

Specific electrostatic interactions between charged amino acid residues regulate binding of von Willebrand factor to blood platelets.
Interlandi G, Yakovenko O, Tu AY, Harris J, Le J, Chen J, L?pez JA, Thomas WE
The Journal of biological chemistry292(45)18608-18617(2017 11)

The BEACH-domain containing protein, Nbeal2, interacts with Dock7, Sec16a and Vac14.
Mayer L, Jasztal M, Pardo M, Aguera de Haro S, Collins J, Bariana TK, Smethurst PA, Grassi L, Petersen R, Nurden P, Favier R, Yu L, Meacham S, Astle WJ, Choudhary J, Yue WW, Ouwehand WH, Guerrero JA
Blood(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that an aspartate at position 1261 is the most critical residue of VWF N-terminal linker for inhibiting binding of VWF A1 domain to GP1BA on platelets in a model simulating blood flow velocity; network of salt bridges between Asp1261 and rest of VWF A1 domain lock N-terminal linker in place such that binding to GP1BA is reduced.
Title: Specific electrostatic interactions between charged amino acid residues regulate binding of von Willebrand factor to blood platelets.

Data show that von Willebrand factor (VWF) is first converted from a compact to linear form by flow, and is subsequently activated to bind platelet glycoprotein Ib alpha polypeptide (GPIbalpha) in a tension-dependent manner.
Title: Flow-induced elongation of von Willebrand factor precedes tension-dependent activation.

Meta-analysis found that glycoprotein Ia C807T T allele or the TT genotype, the Ser-allele of HPA-3 and B allele of glycoprotein Ibalpha variable number tandem repeat polymorphisms were associated with increased risk for ischemic stroke.
Title: Platelet glycoprotein gene Ia C807T, HPA-3, and Ib? VNTR polymorphisms are associated with increased ischemic stroke risk: Evidence from a comprehensive meta-analysis.

Our results suggest that the -5CC genotype in Kozak sequence of GPIb-alpha may be associated with a higher risk of developing arterial ischemia of lower limbs in type 2 diabetes mellitus patients.
Title: Influence of genetic variations in platelet glycoproteins and eNOS in the development of arterial ischaemia of lower limbs in type 2 diabetes mellitus patients.

miR-10a and miR10b regulate the expression of human platelet GP1BA and GP1bb for normal megakaryopoiesis.
Title: MicroRNAs 10a and 10b Regulate the Expression of Human Platelet Glycoprotein Ib? for Normal Megakaryopoiesis.

The following GP1BA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GP1BA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21772	NM_000173.7 Latest version!	Homo sapiens glycoprotein Ib platelet subunit alpha (GP1BA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21772	NM_000173.6	Homo sapiens glycoprotein Ib platelet alpha subunit (GP1BA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GP1BA ( NM_000173.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000164.5 Homo sapiens glycoprotein Ib platelet alpha subunit (GP1BA), mRNA.

Price & Availability↑

CloneID	OHu21772
Clone ID Related Accession (Same CDS sequence)	NM_000173.6 , NM_000173.7
Accession Version	NM_000173.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1959bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	platelet glycoprotein Ib alpha chain precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY099146.1, KC120774.1, BC027955.1 and AI357061.1. On Jan 15, 2015 this sequence version replaced NM_000173.5. CCDS Note: The coding region has been updated to include an additional segment in the coding region. This region corresponds to a tandem repeat encoding a 13 aa segment, which is present 3 times in the reference genome sequence. These tandem repeats are described in PMID:1577776. It should be noted that the majority of available transcript data represent an allele lacking one or more of these repeats, whereas this update represents the number of repeats found in the reference genome sequence. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HY099146.1, KC120774.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:3497398) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTCTCC TCCTCTTGCT GCTCCTGCTG CCAAGCCCCT TACACCCCCA CCCCATCTGT 
GAGGTCTCCA AAGTGGCCAG CCACCTAGAA GTGAACTGTG ACAAGAGGAA TCTGACAGCG 
CTGCCTCCAG ACCTGCCGAA AGACACAACC ATCCTCCACC TGAGTGAGAA CCTCCTGTAC 
ACCTTCTCCC TGGCAACCCT GATGCCTTAC ACTCGCCTCA CTCAGCTGAA CCTAGATAGG 
TGCGAGCTCA CCAAGCTCCA GGTCGATGGG ACGCTGCCAG TGCTGGGGAC CCTGGATCTA 
TCCCACAATC AGCTGCAAAG CCTGCCCTTG CTAGGGCAGA CACTGCCTGC TCTCACCGTC 
CTGGACGTCT CCTTCAACCG GCTGACCTCG CTGCCTCTTG GTGCCCTGCG TGGTCTTGGC 
GAACTCCAAG AGCTCTACCT GAAAGGCAAT GAGCTGAAGA CCCTGCCCCC AGGGCTCCTG 
ACGCCCACAC CCAAGCTGGA GAAGCTCAGT CTGGCTAACA ACAACTTGAC TGAGCTCCCC 
GCTGGGCTCC TGAATGGGCT GGAGAATCTC GACACCCTTC TCCTCCAAGA GAACTCGCTG 
TATACAATAC CAAAGGGCTT TTTTGGGTCC CACCTCCTGC CTTTTGCTTT TCTCCACGGG 
AACCCCTGGT TATGCAACTG TGAGATCCTC TATTTTCGTC GCTGGCTGCA GGACAATGCT 
GAAAATGTCT ACGTATGGAA GCAAGGTGTG GACGTCAAGG CCATGACCTC TAACGTGGCC 
AGTGTGCAGT GTGACAATTC AGACAAGTTT CCCGTCTACA AATACCCAGG AAAGGGGTGC 
CCCACCCTTG GTGATGAAGG TGACACAGAC CTATATGATT ACTACCCAGA AGAGGACACT 
GAGGGCGATA AGGTGCGTGC CACAAGGACT GTGGTCAAGT TCCCCACCAA AGCCCATACA 
ACCCCCTGGG GTCTATTCTA CTCATGGTCC ACTGCTTCTC TAGACAGCCA AATGCCCTCC 
TCCTTGCATC CAACACAAGA ATCCACTAAG GAGCAGACCA CATTCCCACC TAGATGGACC 
CCAAATTTCA CACTTCACAT GGAATCCATC ACATTCTCCA AAACTCCAAA ATCCACTACT 
GAACCAACCC CAAGCCCGAC CACCTCAGAG CCCGTCCCGG AGCCCGCCCC AAACATGACC 
ACCCTGGAGC CCACTCCAAG CCCGACCACC CCAGAGCCCA CCTCAGAGCC CGCCCCCAGC 
CCGACCACCC CGGAGCCCAC CTCAGAGCCC GCCCCCAGCC CGACCACCCC AGAGCCCACC 
TCAGAGCCCG CCCCCAGCCC GACCACCCCG GAGCCCACCC CAATCCCGAC CATCGCCACA 
AGCCCGACCA TCCTGGTGTC TGCCACAAGC CTGATCACTC CAAAAAGCAC ATTTTTAACT 
ACCACAAAAC CCGTATCACT CTTAGAATCC ACCAAAAAAA CCATCCCTGA ACTTGATCAG 
CCACCAAAGC TCCGTGGGGT GCTCCAAGGG CATTTGGAGA GCTCCAGAAA TGACCCTTTT 
CTCCACCCCG ACTTTTGCTG CCTCCTCCCC CTGGGCTTCT ATGTCTTGGG TCTCTTCTGG 
CTGCTCTTTG CCTCTGTGGT CCTCATCCTG CTGCTGAGCT GGGTTGGGCA TGTGAAACCA 
CAGGCCCTGG ACTCTGGCCA AGGTGCTGCT CTGACCACAG CCACACAAAC CACACACCTG 
GAGCTGCAGA GGGGACGGCA AGTGACAGTG CCCCGGGCCT GGCTGCTCTT CCTTCGAGGT 
TCGCTTCCCA CTTTCCGCTC CAGCCTCTTC CTGTGGGTAC GGCCTAATGG CCGTGTGGGG 
CCTCTAGTGG CAGGAAGGAG GCCCTCAGCT CTGAGTCAGG GTCGTGGTCA GGACCTGCTG 
AGCACAGTGA GCATTAGGTA CTCTGGCCAC AGCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000164.5
CDS	98..2056
Translation	MPLLLLLLLLPSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPLGFYVLGLFWLLFASVVLILLLSWVGHVKPQALDSGQGAALTTATQTTHLELQRGRQVTVPRAWLLFLRGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLSTVSIRYSGHSL

Target ORF information:

RefSeq Version	NM_000173.6
Organism	Homo sapiens(human)
Definition	Homo sapiens glycoprotein Ib platelet alpha subunit (GP1BA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000173.6

ORF Insert Sequence:

ATGCCTCTCC TCCTCTTGCT GCTCCTGCTG CCAAGCCCCT TACACCCCCA CCCCATCTGT 
GAGGTCTCCA AAGTGGCCAG CCACCTAGAA GTGAACTGTG ACAAGAGGAA TCTGACAGCG 
CTGCCTCCAG ACCTGCCGAA AGACACAACC ATCCTCCACC TGAGTGAGAA CCTCCTGTAC 
ACCTTCTCCC TGGCAACCCT GATGCCTTAC ACTCGCCTCA CTCAGCTGAA CCTAGATAGG 
TGCGAGCTCA CCAAGCTCCA GGTCGATGGG ACGCTGCCAG TGCTGGGGAC CCTGGATCTA 
TCCCACAATC AGCTGCAAAG CCTGCCCTTG CTAGGGCAGA CACTGCCTGC TCTCACCGTC 
CTGGACGTCT CCTTCAACCG GCTGACCTCG CTGCCTCTTG GTGCCCTGCG TGGTCTTGGC 
GAACTCCAAG AGCTCTACCT GAAAGGCAAT GAGCTGAAGA CCCTGCCCCC AGGGCTCCTG 
ACGCCCACAC CCAAGCTGGA GAAGCTCAGT CTGGCTAACA ACAACTTGAC TGAGCTCCCC 
GCTGGGCTCC TGAATGGGCT GGAGAATCTC GACACCCTTC TCCTCCAAGA GAACTCGCTG 
TATACAATAC CAAAGGGCTT TTTTGGGTCC CACCTCCTGC CTTTTGCTTT TCTCCACGGG 
AACCCCTGGT TATGCAACTG TGAGATCCTC TATTTTCGTC GCTGGCTGCA GGACAATGCT 
GAAAATGTCT ACGTATGGAA GCAAGGTGTG GACGTCAAGG CCATGACCTC TAACGTGGCC 
AGTGTGCAGT GTGACAATTC AGACAAGTTT CCCGTCTACA AATACCCAGG AAAGGGGTGC 
CCCACCCTTG GTGATGAAGG TGACACAGAC CTATATGATT ACTACCCAGA AGAGGACACT 
GAGGGCGATA AGGTGCGTGC CACAAGGACT GTGGTCAAGT TCCCCACCAA AGCCCATACA 
ACCCCCTGGG GTCTATTCTA CTCATGGTCC ACTGCTTCTC TAGACAGCCA AATGCCCTCC 
TCCTTGCATC CAACACAAGA ATCCACTAAG GAGCAGACCA CATTCCCACC TAGATGGACC 
CCAAATTTCA CACTTCACAT GGAATCCATC ACATTCTCCA AAACTCCAAA ATCCACTACT 
GAACCAACCC CAAGCCCGAC CACCTCAGAG CCCGTCCCGG AGCCCGCCCC AAACATGACC 
ACCCTGGAGC CCACTCCAAG CCCGACCACC CCAGAGCCCA CCTCAGAGCC CGCCCCCAGC 
CCGACCACCC CGGAGCCCAC CTCAGAGCCC GCCCCCAGCC CGACCACCCC AGAGCCCACC 
TCAGAGCCCG CCCCCAGCCC GACCACCCCG GAGCCCACCC CAATCCCGAC CATCGCCACA 
AGCCCGACCA TCCTGGTGTC TGCCACAAGC CTGATCACTC CAAAAAGCAC ATTTTTAACT 
ACCACAAAAC CCGTATCACT CTTAGAATCC ACCAAAAAAA CCATCCCTGA ACTTGATCAG 
CCACCAAAGC TCCGTGGGGT GCTCCAAGGG CATTTGGAGA GCTCCAGAAA TGACCCTTTT 
CTCCACCCCG ACTTTTGCTG CCTCCTCCCC CTGGGCTTCT ATGTCTTGGG TCTCTTCTGG 
CTGCTCTTTG CCTCTGTGGT CCTCATCCTG CTGCTGAGCT GGGTTGGGCA TGTGAAACCA 
CAGGCCCTGG ACTCTGGCCA AGGTGCTGCT CTGACCACAG CCACACAAAC CACACACCTG 
GAGCTGCAGA GGGGACGGCA AGTGACAGTG CCCCGGGCCT GGCTGCTCTT CCTTCGAGGT 
TCGCTTCCCA CTTTCCGCTC CAGCCTCTTC CTGTGGGTAC GGCCTAATGG CCGTGTGGGG 
CCTCTAGTGG CAGGAAGGAG GCCCTCAGCT CTGAGTCAGG GTCGTGGTCA GGACCTGCTG 
AGCACAGTGA GCATTAGGTA CTCTGGCCAC AGCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GP1BA ( NM_000173.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_000164.5 Homo sapiens glycoprotein Ib platelet subunit alpha (GP1BA), mRNA.

Price & Availability↑

CloneID	OHu21772
Clone ID Related Accession (Same CDS sequence)	NM_000173.6 , NM_000173.7
Accession Version	NM_000173.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1959bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	platelet glycoprotein Ib alpha chain precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY099146.1, KC120774.1 and BC027955.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000173.6. CCDS Note: The coding region has been updated to include an additional segment in the coding region. This region corresponds to a tandem repeat encoding a 13 aa segment, which is present 3 times in the reference genome sequence. These tandem repeats are described in PMID:1577776. It should be noted that the majority of available transcript data represent an allele lacking one or more of these repeats, whereas this update represents the number of repeats found in the reference genome sequence. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KC120774.1, KC120776.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:3497398) MANE Ensembl match :: ENST00000329125.6/ ENSP00000329380.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTCTCC TCCTCTTGCT GCTCCTGCTG CCAAGCCCCT TACACCCCCA CCCCATCTGT 
GAGGTCTCCA AAGTGGCCAG CCACCTAGAA GTGAACTGTG ACAAGAGGAA TCTGACAGCG 
CTGCCTCCAG ACCTGCCGAA AGACACAACC ATCCTCCACC TGAGTGAGAA CCTCCTGTAC 
ACCTTCTCCC TGGCAACCCT GATGCCTTAC ACTCGCCTCA CTCAGCTGAA CCTAGATAGG 
TGCGAGCTCA CCAAGCTCCA GGTCGATGGG ACGCTGCCAG TGCTGGGGAC CCTGGATCTA 
TCCCACAATC AGCTGCAAAG CCTGCCCTTG CTAGGGCAGA CACTGCCTGC TCTCACCGTC 
CTGGACGTCT CCTTCAACCG GCTGACCTCG CTGCCTCTTG GTGCCCTGCG TGGTCTTGGC 
GAACTCCAAG AGCTCTACCT GAAAGGCAAT GAGCTGAAGA CCCTGCCCCC AGGGCTCCTG 
ACGCCCACAC CCAAGCTGGA GAAGCTCAGT CTGGCTAACA ACAACTTGAC TGAGCTCCCC 
GCTGGGCTCC TGAATGGGCT GGAGAATCTC GACACCCTTC TCCTCCAAGA GAACTCGCTG 
TATACAATAC CAAAGGGCTT TTTTGGGTCC CACCTCCTGC CTTTTGCTTT TCTCCACGGG 
AACCCCTGGT TATGCAACTG TGAGATCCTC TATTTTCGTC GCTGGCTGCA GGACAATGCT 
GAAAATGTCT ACGTATGGAA GCAAGGTGTG GACGTCAAGG CCATGACCTC TAACGTGGCC 
AGTGTGCAGT GTGACAATTC AGACAAGTTT CCCGTCTACA AATACCCAGG AAAGGGGTGC 
CCCACCCTTG GTGATGAAGG TGACACAGAC CTATATGATT ACTACCCAGA AGAGGACACT 
GAGGGCGATA AGGTGCGTGC CACAAGGACT GTGGTCAAGT TCCCCACCAA AGCCCATACA 
ACCCCCTGGG GTCTATTCTA CTCATGGTCC ACTGCTTCTC TAGACAGCCA AATGCCCTCC 
TCCTTGCATC CAACACAAGA ATCCACTAAG GAGCAGACCA CATTCCCACC TAGATGGACC 
CCAAATTTCA CACTTCACAT GGAATCCATC ACATTCTCCA AAACTCCAAA ATCCACTACT 
GAACCAACCC CAAGCCCGAC CACCTCAGAG CCCGTCCCGG AGCCCGCCCC AAACATGACC 
ACCCTGGAGC CCACTCCAAG CCCGACCACC CCAGAGCCCA CCTCAGAGCC CGCCCCCAGC 
CCGACCACCC CGGAGCCCAC CTCAGAGCCC GCCCCCAGCC CGACCACCCC AGAGCCCACC 
TCAGAGCCCG CCCCCAGCCC GACCACCCCG GAGCCCACCC CAATCCCGAC CATCGCCACA 
AGCCCGACCA TCCTGGTGTC TGCCACAAGC CTGATCACTC CAAAAAGCAC ATTTTTAACT 
ACCACAAAAC CCGTATCACT CTTAGAATCC ACCAAAAAAA CCATCCCTGA ACTTGATCAG 
CCACCAAAGC TCCGTGGGGT GCTCCAAGGG CATTTGGAGA GCTCCAGAAA TGACCCTTTT 
CTCCACCCCG ACTTTTGCTG CCTCCTCCCC CTGGGCTTCT ATGTCTTGGG TCTCTTCTGG 
CTGCTCTTTG CCTCTGTGGT CCTCATCCTG CTGCTGAGCT GGGTTGGGCA TGTGAAACCA 
CAGGCCCTGG ACTCTGGCCA AGGTGCTGCT CTGACCACAG CCACACAAAC CACACACCTG 
GAGCTGCAGA GGGGACGGCA AGTGACAGTG CCCCGGGCCT GGCTGCTCTT CCTTCGAGGT 
TCGCTTCCCA CTTTCCGCTC CAGCCTCTTC CTGTGGGTAC GGCCTAATGG CCGTGTGGGG 
CCTCTAGTGG CAGGAAGGAG GCCCTCAGCT CTGAGTCAGG GTCGTGGTCA GGACCTGCTG 
AGCACAGTGA GCATTAGGTA CTCTGGCCAC AGCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000164.5
CDS	96..2054
Translation	MPLLLLLLLLPSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPLGFYVLGLFWLLFASVVLILLLSWVGHVKPQALDSGQGAALTTATQTTHLELQRGRQVTVPRAWLLFLRGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLSTVSIRYSGHSL

Target ORF information:

RefSeq Version	NM_000173.7
Organism	Homo sapiens(human)
Definition	Homo sapiens glycoprotein Ib platelet subunit alpha (GP1BA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000173.7

ORF Insert Sequence:

ATGCCTCTCC TCCTCTTGCT GCTCCTGCTG CCAAGCCCCT TACACCCCCA CCCCATCTGT 
GAGGTCTCCA AAGTGGCCAG CCACCTAGAA GTGAACTGTG ACAAGAGGAA TCTGACAGCG 
CTGCCTCCAG ACCTGCCGAA AGACACAACC ATCCTCCACC TGAGTGAGAA CCTCCTGTAC 
ACCTTCTCCC TGGCAACCCT GATGCCTTAC ACTCGCCTCA CTCAGCTGAA CCTAGATAGG 
TGCGAGCTCA CCAAGCTCCA GGTCGATGGG ACGCTGCCAG TGCTGGGGAC CCTGGATCTA 
TCCCACAATC AGCTGCAAAG CCTGCCCTTG CTAGGGCAGA CACTGCCTGC TCTCACCGTC 
CTGGACGTCT CCTTCAACCG GCTGACCTCG CTGCCTCTTG GTGCCCTGCG TGGTCTTGGC 
GAACTCCAAG AGCTCTACCT GAAAGGCAAT GAGCTGAAGA CCCTGCCCCC AGGGCTCCTG 
ACGCCCACAC CCAAGCTGGA GAAGCTCAGT CTGGCTAACA ACAACTTGAC TGAGCTCCCC 
GCTGGGCTCC TGAATGGGCT GGAGAATCTC GACACCCTTC TCCTCCAAGA GAACTCGCTG 
TATACAATAC CAAAGGGCTT TTTTGGGTCC CACCTCCTGC CTTTTGCTTT TCTCCACGGG 
AACCCCTGGT TATGCAACTG TGAGATCCTC TATTTTCGTC GCTGGCTGCA GGACAATGCT 
GAAAATGTCT ACGTATGGAA GCAAGGTGTG GACGTCAAGG CCATGACCTC TAACGTGGCC 
AGTGTGCAGT GTGACAATTC AGACAAGTTT CCCGTCTACA AATACCCAGG AAAGGGGTGC 
CCCACCCTTG GTGATGAAGG TGACACAGAC CTATATGATT ACTACCCAGA AGAGGACACT 
GAGGGCGATA AGGTGCGTGC CACAAGGACT GTGGTCAAGT TCCCCACCAA AGCCCATACA 
ACCCCCTGGG GTCTATTCTA CTCATGGTCC ACTGCTTCTC TAGACAGCCA AATGCCCTCC 
TCCTTGCATC CAACACAAGA ATCCACTAAG GAGCAGACCA CATTCCCACC TAGATGGACC 
CCAAATTTCA CACTTCACAT GGAATCCATC ACATTCTCCA AAACTCCAAA ATCCACTACT 
GAACCAACCC CAAGCCCGAC CACCTCAGAG CCCGTCCCGG AGCCCGCCCC AAACATGACC 
ACCCTGGAGC CCACTCCAAG CCCGACCACC CCAGAGCCCA CCTCAGAGCC CGCCCCCAGC 
CCGACCACCC CGGAGCCCAC CTCAGAGCCC GCCCCCAGCC CGACCACCCC AGAGCCCACC 
TCAGAGCCCG CCCCCAGCCC GACCACCCCG GAGCCCACCC CAATCCCGAC CATCGCCACA 
AGCCCGACCA TCCTGGTGTC TGCCACAAGC CTGATCACTC CAAAAAGCAC ATTTTTAACT 
ACCACAAAAC CCGTATCACT CTTAGAATCC ACCAAAAAAA CCATCCCTGA ACTTGATCAG 
CCACCAAAGC TCCGTGGGGT GCTCCAAGGG CATTTGGAGA GCTCCAGAAA TGACCCTTTT 
CTCCACCCCG ACTTTTGCTG CCTCCTCCCC CTGGGCTTCT ATGTCTTGGG TCTCTTCTGG 
CTGCTCTTTG CCTCTGTGGT CCTCATCCTG CTGCTGAGCT GGGTTGGGCA TGTGAAACCA 
CAGGCCCTGG ACTCTGGCCA AGGTGCTGCT CTGACCACAG CCACACAAAC CACACACCTG 
GAGCTGCAGA GGGGACGGCA AGTGACAGTG CCCCGGGCCT GGCTGCTCTT CCTTCGAGGT 
TCGCTTCCCA CTTTCCGCTC CAGCCTCTTC CTGTGGGTAC GGCCTAATGG CCGTGTGGGG 
CCTCTAGTGG CAGGAAGGAG GCCCTCAGCT CTGAGTCAGG GTCGTGGTCA GGACCTGCTG 
AGCACAGTGA GCATTAGGTA CTCTGGCCAC AGCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Specific electrostatic interactions between charged amino acid residues regulate binding of von Willebrand factor to blood platelets.
The Journal of biological chemistry292(45)18608-18617(2017 11)
Interlandi G,Yakovenko O,Tu AY,Harris J,Le J,Chen J,L?pez JA,Thomas WE

The BEACH-domain containing protein, Nbeal2, interacts with Dock7, Sec16a and Vac14.
Blood(2017 Nov)
Mayer L,Jasztal M,Pardo M,Aguera de Haro S,Collins J,Bariana TK,Smethurst PA,Grassi L,Petersen R,Nurden P,Favier R,Yu L,Meacham S,Astle WJ,Choudhary J,Yue WW,Ouwehand WH,Guerrero JA

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GP1BA cDNA ORF clone, Homo sapiens(human)

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