GNG7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GNG7
Entrez Gene ID	2788
Full Name	G protein subunit gamma 7
General protein information	Preferred Names G protein subunit gamma 7 Names guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 guanine nucleotide binding protein (G protein), gamma 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Disorder MIM:	604430

mRNA and Protein(s)

mRNA	Protein	Name
XM_017026606.1	XP_016882095.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1
NM_052847.3	NP_443079.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 precursor
NM_052847.2	NP_443079.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 precursor

Pathways from BioSystems

Homologies

	GNG7	XP_001098800.1
Canis lupus familiaris (dog)	GNG7	XP_003432853.1
Gallus gallus (chicken)	LOC100858976	XP_003643464.1
Homo sapiens (human)	GNG7	NP_443079.1
Bos taurus (cattle)	GNG7	NP_001106785.1
Xenopus tropicalis (tropical clawed frog)	gng7	NP_001017133.1
Rattus norvegicus (Norway rat)	Gng7	NP_077052.1
Pan troglodytes (chimpanzee)	GNG7	XP_001152049.1
Mus musculus (house mouse)	Gng7	NP_001033744.1
Danio rerio (zebrafish)	gng7	NP_001002397.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of guanine nucleotide-binding protein ?-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling.
Demokan S, Chuang AY, Chang X, Khan T, Smith IM, Pattani KM, Dasgupta S, Begum S, Khan Z, Liegeois NJ, Westra WH, Sidransky D, Koch W, Califano JA
International journal of oncology42(4)1427-36(2013 Apr)

Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
Deng X, Sabino EC, Cunha-Neto E, Ribeiro AL, Ianni B, Mady C, Busch MP, Seielstad M,
PloS one8(11)e79629(2013)

Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck.
Hartmann S, Szaumkessel M, Salaverria I, Simon R, Sauter G, Kiwerska K, Gawecki W, Bodnar M, Marszalek A, Richter J, Brauze D, Zemke N, Jarmuz M, Hansmann ML, Siebert R, Szyfter K, Giefing M
Journal of applied genetics53(2)167-74(2012 May)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Human G-protein gamma 7 in extrahepatic cholangiocarcinoma and its clinicopathological significance.
Wang M, Gong B, Li Y, Wang Y
Hematology/oncology and stem cell therapy3(2)66-70(2010)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GNG7 is a highly specific promoter methylated gene associated with head and neck cancer.
Title: Identification of guanine nucleotide-binding protein ?-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling.

Loss of GNG7 protein expression is a frequent event in head and neck cancer with hypermethylation of the promoter region of GNG7 being probably the mechanism for the observed inactivation.
Title: Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Reduced expression of G-gamma 7 is associated with the histological grade of EHCC and may prove to be a useful marker for predicting the prognosis of human EHCC.
Title: Human G-protein gamma 7 in extrahepatic cholangiocarcinoma and its clinicopathological significance.

GNG7 suppression represents a new prognostic indicator in cases of oesophageal cancer.
Title: Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer.

The following GNG7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNG7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25421	NM_052847.3 Latest version!	Homo sapiens G protein subunit gamma 7 (GNG7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu25421	XM_017026606.1 Latest version!	Homo sapiens G protein subunit gamma 7 (GNG7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu25421	NM_052847.2	Homo sapiens G protein subunit gamma 7 (GNG7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GNG7 ( NM_052847.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_443079.1 Homo sapiens G protein subunit gamma 7 (GNG7), mRNA.

Price & Availability↑

CloneID	OHu25421
Clone ID Related Accession (Same CDS sequence)	XM_017026606.1 , NM_052847.3 , NM_052847.2
Accession Version	NM_052847.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC014466.1, DA247608.1, AC005512.1 and BC053630.1. On Nov 23, 2018 this sequence version replaced NM_052847.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.411482.1, SRR1660805.188960.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153031, SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000382159.8/ ENSP00000371594.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCAGCCA CTAACAACAT AGCCCAGGCC CGGAAGCTGG TGGAACAGCT ACGCATAGAA 
GCCGGGATTG AGCGCATCAA GGTCTCCAAA GCGGCGTCTG ACCTCATGAG CTACTGTGAG 
CAACATGCCC GGAACGACCC CCTGCTGGTC GGAGTCCCTG CCTCGGAGAA CCCCTTTAAG 
GACAAGAAAC CTTGTATTAT TTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443079.1
CDS	184..390
Translation	MSATNNIAQARKLVEQLRIEAGIERIKVSKAASDLMSYCEQHARNDPLLVGVPASENPFKDKKPCIIL

Target ORF information:

RefSeq Version	NM_052847.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma 7 (GNG7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052847.3

ORF Insert Sequence:

ATGTCAGCCA CTAACAACAT AGCCCAGGCC CGGAAGCTGG TGGAACAGCT ACGCATAGAA 
GCCGGGATTG AGCGCATCAA GGTCTCCAAA GCGGCGTCTG ACCTCATGAG CTACTGTGAG 
CAACATGCCC GGAACGACCC CCTGCTGGTC GGAGTCCCTG CCTCGGAGAA CCCCTTTAAG 
GACAAGAAAC CTTGTATTAT TTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNG7 ( NM_052847.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_443079.1 Homo sapiens G protein subunit gamma 7 (GNG7), mRNA.

Price & Availability↑

CloneID	OHu25421
Clone ID Related Accession (Same CDS sequence)	XM_017026606.1 , NM_052847.3 , NM_052847.2
Accession Version	NM_052847.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA106844.1, BC014466.1, DA247608.1, AC005512.1 and BC053630.1. On Jun 19, 2007 this sequence version replaced NM_052847.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053630.1, SRR1660803.28462.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153031, SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGCCA CTAACAACAT AGCCCAGGCC CGGAAGCTGG TGGAACAGCT ACGCATAGAA 
GCCGGGATTG AGCGCATCAA GGTCTCCAAA GCGGCGTCTG ACCTCATGAG CTACTGTGAG 
CAACATGCCC GGAACGACCC CCTGCTGGTC GGAGTCCCTG CCTCGGAGAA CCCCTTTAAG 
GACAAGAAAC CTTGTATTAT TTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443079.1
CDS	238..444
Translation	MSATNNIAQARKLVEQLRIEAGIERIKVSKAASDLMSYCEQHARNDPLLVGVPASENPFKDKKPCIIL

Target ORF information:

RefSeq Version	NM_052847.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma 7 (GNG7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052847.2

ORF Insert Sequence:

ATGTCAGCCA CTAACAACAT AGCCCAGGCC CGGAAGCTGG TGGAACAGCT ACGCATAGAA 
GCCGGGATTG AGCGCATCAA GGTCTCCAAA GCGGCGTCTG ACCTCATGAG CTACTGTGAG 
CAACATGCCC GGAACGACCC CCTGCTGGTC GGAGTCCCTG CCTCGGAGAA CCCCTTTAAG 
GACAAGAAAC CTTGTATTAT TTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNG7 ( XM_017026606.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882095.1 Homo sapiens G protein subunit gamma 7 (GNG7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu25421
Clone ID Related Accession (Same CDS sequence)	XM_017026606.1 , NM_052847.3 , NM_052847.2
Accession Version	XM_017026606.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCAGCCA CTAACAACAT AGCCCAGGCC CGGAAGCTGG TGGAACAGCT ACGCATAGAA 
GCCGGGATTG AGCGCATCAA GGTCTCCAAA GCGGCGTCTG ACCTCATGAG CTACTGTGAG 
CAACATGCCC GGAACGACCC CCTGCTGGTC GGAGTCCCTG CCTCGGAGAA CCCCTTTAAG 
GACAAGAAAC CTTGTATTAT TTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882095.1
CDS	347..553
Translation	MSATNNIAQARKLVEQLRIEAGIERIKVSKAASDLMSYCEQHARNDPLLVGVPASENPFKDKKPCIIL

Target ORF information:

RefSeq Version	XM_017026606.1
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit gamma 7 (GNG7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026606.1

ORF Insert Sequence:

ATGTCAGCCA CTAACAACAT AGCCCAGGCC CGGAAGCTGG TGGAACAGCT ACGCATAGAA 
GCCGGGATTG AGCGCATCAA GGTCTCCAAA GCGGCGTCTG ACCTCATGAG CTACTGTGAG 
CAACATGCCC GGAACGACCC CCTGCTGGTC GGAGTCCCTG CCTCGGAGAA CCCCTTTAAG 
GACAAGAAAC CTTGTATTAT TTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of guanine nucleotide-binding protein ?-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling.
International journal of oncology42(4)1427-36(2013 Apr)
Demokan S,Chuang AY,Chang X,Khan T,Smith IM,Pattani KM,Dasgupta S,Begum S,Khan Z,Liegeois NJ,Westra WH,Sidransky D,Koch W,Califano JA

Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
PloS one8(11)e79629(2013)
Deng X,Sabino EC,Cunha-Neto E,Ribeiro AL,Ianni B,Mady C,Busch MP,Seielstad M,

Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck.
Journal of applied genetics53(2)167-74(2012 May)
Hartmann S,Szaumkessel M,Salaverria I,Simon R,Sauter G,Kiwerska K,Gawecki W,Bodnar M,Marszalek A,Richter J,Brauze D,Zemke N,Jarmuz M,Hansmann ML,Siebert R,Szyfter K,Giefing M

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

Human G-protein gamma 7 in extrahepatic cholangiocarcinoma and its clinicopathological significance.
Hematology/oncology and stem cell therapy3(2)66-70(2010)
Wang M,Gong B,Li Y,Wang Y

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GNG7 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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