GNAO1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GNAO1
Entrez Gene ID	2775
Full Name	G protein subunit alpha o1
Synonyms	EIEE17,G-ALPHA-o,GNAO,HLA-DQB1,NEDIM
General protein information	Preferred Names G protein subunit alpha o1 Names guanine nucleotide-binding protein G(o) subunit alpha GO2-q chimeric G-protein guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O guanine nucleotide-binding regulatory protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q13
Summary	The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
Disorder MIM:	139311
Disorder Html:	Epileptic encephalopathy, early infantile, 17, 615473 (3); Neurodevelopmental disorder with involuntary movements, 617493 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011523003.2	XP_011521305.1	guanine nucleotide-binding protein G(o) subunit alpha isoform X1
NM_020988.2	NP_066268.1	guanine nucleotide-binding protein G(o) subunit alpha isoform a
NM_138736.2	NP_620073.2	guanine nucleotide-binding protein G(o) subunit alpha isoform b
NM_138736.3	NP_620073.2	guanine nucleotide-binding protein G(o) subunit alpha isoform b
NM_020988.3	NP_066268.1	guanine nucleotide-binding protein G(o) subunit alpha isoform a
XM_011523003.3	XP_011521305.1	guanine nucleotide-binding protein G(o) subunit alpha isoform X1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	gnao1	NP_001016995.1
	GNAO1	XP_001096035.2
Pan troglodytes (chimpanzee)	GNAO1	XP_510976.3
Canis lupus familiaris (dog)	GNAO1	XP_005617599.1
Bos taurus (cattle)	GNAO1	NP_776750.1
Gallus gallus (chicken)	GNAO1	NP_001264479.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005773	XP_315788.3
Caenorhabditis elegans (roundworm)	goa-1	NP_492108.1
Homo sapiens (human)	GNAO1	NP_066268.1
Mus musculus (house mouse)	Gnao1	NP_034438.1
Rattus norvegicus (Norway rat)	Gnao1	NP_059023.1
Danio rerio (zebrafish)	gnao1a	NP_957081.1
Drosophila melanogaster (fruit fly)	G-oalpha47A	NP_724934.1

Gene Ontology
Bibliography

Related articles in PubMed

Expanding Phenotype of De Novo Mutations in GNAO1: Four New Cases and Review of Literature.
Schorling DC, Dietel T, Evers C, Hinderhofer K, Korinthenberg R, Ezzo D, B?nnemann CG, Kirschner J
Neuropediatrics48(5)371-377(2017 10)

Movement disorder in
Feng H, Sj?gren B, Karaj B, Shaw V, Gezer A, Neubig RR
Neurology89(8)762-770(2017 Aug)

GNAO1-associated epileptic encephalopathy and movement disorders: c.607G>A variant represents a probable mutation hotspot with a distinct phenotype.
Arya R, Spaeth C, Gilbert DL, Leach JL, Holland KD
Epileptic disorders : international epilepsy journal with videotape19(1)67-75(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study identified distinct biochemical mechanisms of pathogenic human GNAO1 mutations that may improve the understanding of the heterogeneous clinical spectrum of GNAO1-associated epilepsy and movement disorders. Furthermore, these results also carry significant implications for personalized therapeutics in GNAO1 encephalopathies.
Title: Movement disorder in

The neurological phenotypes associated with GNAO1 mutations appear to lie on a spectrum, and it is possible that the c.607G>A (p.Gly203Arg) variant characterizes a phenotype with both severe epilepsy and chorea.
Title: GNAO1-associated epileptic encephalopathy and movement disorders: c.607G>A variant represents a probable mutation hotspot with a distinct phenotype.

Taken together, the data presented here suggest that TLR2 activation in human mast cells promotes the release of inflammatory mediators via distinct signaling pathways that partially depend on the action of Go proteins.
Title: Toll-like receptor 2-mediated MAPKs and NF-?B activation requires the GNAO1-dependent pathway in human mast cells.

Endothelial cells in capillary malformations are enriched for GNAQ mutations and are likely responsible for the pathophysiology underlying capillary malformation.
Title: Endothelial Cells from Capillary Malformations Are Enriched for Somatic GNAQ Mutations.

GNAO1 is a disease-causing gene for the autosomal dominant form of early infantile epileptic encephalopathy. The novel pathogenic variant identified in should contribute to our understanding of the expanding spectrum of infantile-onset epilepsy.
Title: Clinical whole-exome sequencing reveals a novel missense pathogenic variant of GNAO1 in a patient with infantile-onset epilepsy.

The following GNAO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNAO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13586	NM_020988.3 Latest version!	Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu13628	NM_138736.3 Latest version!	Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu58003	XM_011523003.3 Latest version!	Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu13628	NM_138736.2	Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu13586	NM_020988.2	Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu58003	XM_011523003.2	Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GNAO1 ( NM_020988.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_066268.1 Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13586
Clone ID Related Accession (Same CDS sequence)	NM_020988.2 , NM_020988.3
Accession Version	NM_020988.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(o) subunit alpha isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA500625.1, AK056008.1, DA529437.1, BC030027.2 and AC009102.10. This sequence is a reference standard in the RefSeqGene project. On Dec 14, 2007 this sequence version replaced NM_020988.1. Transcript Variant: This variant (1) represents the shorter transcript and encodes isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.168148.1, SRR1660805.22343.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGATGTA CTCTGAGCGC AGAGGAGAGA GCCGCCCTCG AGCGGAGCAA GGCGATTGAG 
AAAAACCTCA AAGAGGATGG CATCAGCGCC GCCAAAGACG TGAAATTACT CCTGCTCGGG 
GCTGGAGAAT CAGGAAAAAG CACCATTGTG AAGCAGATGA AGATCATCCA TGAAGATGGC 
TTCTCCGGAG AAGACGTGAA ACAGTACAAG CCTGTTGTCT ACAGCAACAC TATCCAGTCC 
CTGGCAGCCA TCGTCCGGGC CATGGACACT TTGGGCATCG AATATGGTGA TAAGGAGAGA 
AAGGCTGACG CCAAGATGGT GTGTGATGTG GTGAGTCGGA TGGAAGACAC CGAGCCCTTC 
TCTGCAGAGC TGCTTTCTGC CATGATGCGG CTCTGGGGCG ACTCAGGAAT CCAAGAGTGC 
TTCAACCGGT CCCGGGAGTA TCAGCTCAAC GACTCTGCCA AATACTACCT GGACAGCCTG 
GATCGGATTG GGGCCGCCGA CTACCAGCCC ACCGAGCAGG ACATCCTCCG AACCAGGGTC 
AAAACCACTG GCATCGTAGA AACCCACTTC ACATTCAAGA ACCTCCACTT CAGGCTGTTT 
GACGTCGGAG GCCAGCGATC TGAACGCAAG AAGTGGATCC ATTGCTTCGA GGACGTCACG 
GCCATCATTT TCTGTGTCGC GCTCAGCGGC TATGACCAGG TGCTCCACGA AGACGAAACC 
ACGAACCGCA TGCACGAGTC TCTCATGCTC TTCGACTCCA TCTGTAACAA CAAGTTCTTC 
ATCGATACCT CCATCATTCT CTTCCTCAAC AAGAAAGATC TCTTTGGCGA GAAGATCAAG 
AAGTCACCTT TGACCATCTG CTTTCCTGAA TACACAGGCC CCAATACCTA TGAAGACGCA 
GCCGCCTACA TCCAAGCACA ATTTGAAAGC AAAAACCGCT CACCCAACAA AGAAATATAT 
TGTCACATGA CTTGTGCCAC AGACACGAAT AACATCCAGG TGGTGTTCGA CGCCGTCACC 
GACATCATCA TTGCCAACAA CCTCCGGGGC TGCGGCTTGT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066268.1
CDS	898..1962
Translation	MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY

Target ORF information:

RefSeq Version	NM_020988.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020988.2

ORF Insert Sequence:

ATGGGATGTA CTCTGAGCGC AGAGGAGAGA GCCGCCCTCG AGCGGAGCAA GGCGATTGAG 
AAAAACCTCA AAGAGGATGG CATCAGCGCC GCCAAAGACG TGAAATTACT CCTGCTCGGG 
GCTGGAGAAT CAGGAAAAAG CACCATTGTG AAGCAGATGA AGATCATCCA TGAAGATGGC 
TTCTCCGGAG AAGACGTGAA ACAGTACAAG CCTGTTGTCT ACAGCAACAC TATCCAGTCC 
CTGGCAGCCA TCGTCCGGGC CATGGACACT TTGGGCATCG AATATGGTGA TAAGGAGAGA 
AAGGCTGACG CCAAGATGGT GTGTGATGTG GTGAGTCGGA TGGAAGACAC CGAGCCCTTC 
TCTGCAGAGC TGCTTTCTGC CATGATGCGG CTCTGGGGCG ACTCAGGAAT CCAAGAGTGC 
TTCAACCGGT CCCGGGAGTA TCAGCTCAAC GACTCTGCCA AATACTACCT GGACAGCCTG 
GATCGGATTG GGGCCGCCGA CTACCAGCCC ACCGAGCAGG ACATCCTCCG AACCAGGGTC 
AAAACCACTG GCATCGTAGA AACCCACTTC ACATTCAAGA ACCTCCACTT CAGGCTGTTT 
GACGTCGGAG GCCAGCGATC TGAACGCAAG AAGTGGATCC ATTGCTTCGA GGACGTCACG 
GCCATCATTT TCTGTGTCGC GCTCAGCGGC TATGACCAGG TGCTCCACGA AGACGAAACC 
ACGAACCGCA TGCACGAGTC TCTCATGCTC TTCGACTCCA TCTGTAACAA CAAGTTCTTC 
ATCGATACCT CCATCATTCT CTTCCTCAAC AAGAAAGATC TCTTTGGCGA GAAGATCAAG 
AAGTCACCTT TGACCATCTG CTTTCCTGAA TACACAGGCC CCAATACCTA TGAAGACGCA 
GCCGCCTACA TCCAAGCACA ATTTGAAAGC AAAAACCGCT CACCCAACAA AGAAATATAT 
TGTCACATGA CTTGTGCCAC AGACACGAAT AACATCCAGG TGGTGTTCGA CGCCGTCACC 
GACATCATCA TTGCCAACAA CCTCCGGGGC TGCGGCTTGT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNAO1 ( NM_020988.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066268.1 Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13586
Clone ID Related Accession (Same CDS sequence)	NM_020988.2 , NM_020988.3
Accession Version	NM_020988.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(o) subunit alpha isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK056008.1, DA529437.1, BC030027.2 and AC009102.10. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_020988.2. Transcript Variant: This variant (1) represents the shorter transcript and encodes isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.656273.1, SRR3476690.256248.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262493.12/ ENSP00000262493.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGATGTA CTCTGAGCGC AGAGGAGAGA GCCGCCCTCG AGCGGAGCAA GGCGATTGAG 
AAAAACCTCA AAGAGGATGG CATCAGCGCC GCCAAAGACG TGAAATTACT CCTGCTCGGG 
GCTGGAGAAT CAGGAAAAAG CACCATTGTG AAGCAGATGA AGATCATCCA TGAAGATGGC 
TTCTCCGGAG AAGACGTGAA ACAGTACAAG CCTGTTGTCT ACAGCAACAC TATCCAGTCC 
CTGGCAGCCA TCGTCCGGGC CATGGACACT TTGGGCATCG AATATGGTGA TAAGGAGAGA 
AAGGCTGACG CCAAGATGGT GTGTGATGTG GTGAGTCGGA TGGAAGACAC CGAGCCCTTC 
TCTGCAGAGC TGCTTTCTGC CATGATGCGG CTCTGGGGCG ACTCAGGAAT CCAAGAGTGC 
TTCAACCGGT CCCGGGAGTA TCAGCTCAAC GACTCTGCCA AATACTACCT GGACAGCCTG 
GATCGGATTG GGGCCGCCGA CTACCAGCCC ACCGAGCAGG ACATCCTCCG AACCAGGGTC 
AAAACCACTG GCATCGTAGA AACCCACTTC ACATTCAAGA ACCTCCACTT CAGGCTGTTT 
GACGTCGGAG GCCAGCGATC TGAACGCAAG AAGTGGATCC ATTGCTTCGA GGACGTCACG 
GCCATCATTT TCTGTGTCGC GCTCAGCGGC TATGACCAGG TGCTCCACGA AGACGAAACC 
ACGAACCGCA TGCACGAGTC TCTCATGCTC TTCGACTCCA TCTGTAACAA CAAGTTCTTC 
ATCGATACCT CCATCATTCT CTTCCTCAAC AAGAAAGATC TCTTTGGCGA GAAGATCAAG 
AAGTCACCTT TGACCATCTG CTTTCCTGAA TACACAGGCC CCAATACCTA TGAAGACGCA 
GCCGCCTACA TCCAAGCACA ATTTGAAAGC AAAAACCGCT CACCCAACAA AGAAATATAT 
TGTCACATGA CTTGTGCCAC AGACACGAAT AACATCCAGG TGGTGTTCGA CGCCGTCACC 
GACATCATCA TTGCCAACAA CCTCCGGGGC TGCGGCTTGT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066268.1
CDS	748..1812
Translation	MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY

Target ORF information:

RefSeq Version	NM_020988.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020988.3

ORF Insert Sequence:

ATGGGATGTA CTCTGAGCGC AGAGGAGAGA GCCGCCCTCG AGCGGAGCAA GGCGATTGAG 
AAAAACCTCA AAGAGGATGG CATCAGCGCC GCCAAAGACG TGAAATTACT CCTGCTCGGG 
GCTGGAGAAT CAGGAAAAAG CACCATTGTG AAGCAGATGA AGATCATCCA TGAAGATGGC 
TTCTCCGGAG AAGACGTGAA ACAGTACAAG CCTGTTGTCT ACAGCAACAC TATCCAGTCC 
CTGGCAGCCA TCGTCCGGGC CATGGACACT TTGGGCATCG AATATGGTGA TAAGGAGAGA 
AAGGCTGACG CCAAGATGGT GTGTGATGTG GTGAGTCGGA TGGAAGACAC CGAGCCCTTC 
TCTGCAGAGC TGCTTTCTGC CATGATGCGG CTCTGGGGCG ACTCAGGAAT CCAAGAGTGC 
TTCAACCGGT CCCGGGAGTA TCAGCTCAAC GACTCTGCCA AATACTACCT GGACAGCCTG 
GATCGGATTG GGGCCGCCGA CTACCAGCCC ACCGAGCAGG ACATCCTCCG AACCAGGGTC 
AAAACCACTG GCATCGTAGA AACCCACTTC ACATTCAAGA ACCTCCACTT CAGGCTGTTT 
GACGTCGGAG GCCAGCGATC TGAACGCAAG AAGTGGATCC ATTGCTTCGA GGACGTCACG 
GCCATCATTT TCTGTGTCGC GCTCAGCGGC TATGACCAGG TGCTCCACGA AGACGAAACC 
ACGAACCGCA TGCACGAGTC TCTCATGCTC TTCGACTCCA TCTGTAACAA CAAGTTCTTC 
ATCGATACCT CCATCATTCT CTTCCTCAAC AAGAAAGATC TCTTTGGCGA GAAGATCAAG 
AAGTCACCTT TGACCATCTG CTTTCCTGAA TACACAGGCC CCAATACCTA TGAAGACGCA 
GCCGCCTACA TCCAAGCACA ATTTGAAAGC AAAAACCGCT CACCCAACAA AGAAATATAT 
TGTCACATGA CTTGTGCCAC AGACACGAAT AACATCCAGG TGGTGTTCGA CGCCGTCACC 
GACATCATCA TTGCCAACAA CCTCCGGGGC TGCGGCTTGT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNAO1 ( NM_138736.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_620073.2 Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13628
Clone ID Related Accession (Same CDS sequence)	NM_138736.2 , NM_138736.3
Accession Version	NM_138736.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-15
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(o) subunit alpha isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA500625.1, AK056008.1, DA529437.1, BC030027.2, AF493895.1, DA115582.1, BX647214.1 and AL512686.1. On Dec 14, 2007 this sequence version replaced NM_138736.1. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) is the same length but has a distinct C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CR936770.1, AF493895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGATGTA CTCTGAGCGC AGAGGAGAGA GCCGCCCTCG AGCGGAGCAA GGCGATTGAG 
AAAAACCTCA AAGAGGATGG CATCAGCGCC GCCAAAGACG TGAAATTACT CCTGCTCGGG 
GCTGGAGAAT CAGGAAAAAG CACCATTGTG AAGCAGATGA AGATCATCCA TGAAGATGGC 
TTCTCCGGAG AAGACGTGAA ACAGTACAAG CCTGTTGTCT ACAGCAACAC TATCCAGTCC 
CTGGCAGCCA TCGTCCGGGC CATGGACACT TTGGGCATCG AATATGGTGA TAAGGAGAGA 
AAGGCTGACG CCAAGATGGT GTGTGATGTG GTGAGTCGGA TGGAAGACAC CGAGCCCTTC 
TCTGCAGAGC TGCTTTCTGC CATGATGCGG CTCTGGGGCG ACTCAGGAAT CCAAGAGTGC 
TTCAACCGGT CCCGGGAGTA TCAGCTCAAC GACTCTGCCA AATACTACCT GGACAGCCTG 
GATCGGATTG GGGCCGCCGA CTACCAGCCC ACCGAGCAGG ACATCCTCCG AACCAGGGTC 
AAAACCACTG GCATCGTAGA AACCCACTTC ACATTCAAGA ACCTCCACTT CAGGCTGTTT 
GACGTCGGAG GCCAGCGATC TGAACGCAAG AAGTGGATCC ATTGCTTCGA GGACGTCACG 
GCCATCATTT TCTGTGTCGC GCTCAGCGGC TATGACCAGG TGCTCCACGA AGACGAAACC 
ACGAACCGCA TGCACGAATC CCTGAAGCTT TTTGACAGCA TCTGCAACAA CAAATGGTTC 
ACAGACACGT CCATCATCCT GTTTCTTAAC AAGAAGGACA TATTTGAAGA GAAGATCAAG 
AAGTCCCCGC TCACCATCTG CTTTCCTGAA TATACAGGCC CCAGCGCCTT CACAGAAGCC 
GTGGCTTACA TCCAGGCCCA GTACGAGAGC AAGAACAAGT CAGCCCACAA AGAGATCTAC 
ACCCACGTCA CCTGCGCCAC GGACACCAAC AACATCCAGT TTGTCTTTGA TGCTGTGACG 
GACGTCATCA TCGCCAAAAA CCTGCGGGGC TGTGGACTCT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620073.2
CDS	898..1962
Translation	MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLKLFDSICNNKWFTDTSIILFLNKKDIFEEKIKKSPLTICFPEYTGPSAFTEAVAYIQAQYESKNKSAHKEIYTHVTCATDTNNIQFVFDAVTDVIIAKNLRGCGLY

Target ORF information:

RefSeq Version	NM_138736.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138736.2

ORF Insert Sequence:

ATGGGATGTA CTCTGAGCGC AGAGGAGAGA GCCGCCCTCG AGCGGAGCAA GGCGATTGAG 
AAAAACCTCA AAGAGGATGG CATCAGCGCC GCCAAAGACG TGAAATTACT CCTGCTCGGG 
GCTGGAGAAT CAGGAAAAAG CACCATTGTG AAGCAGATGA AGATCATCCA TGAAGATGGC 
TTCTCCGGAG AAGACGTGAA ACAGTACAAG CCTGTTGTCT ACAGCAACAC TATCCAGTCC 
CTGGCAGCCA TCGTCCGGGC CATGGACACT TTGGGCATCG AATATGGTGA TAAGGAGAGA 
AAGGCTGACG CCAAGATGGT GTGTGATGTG GTGAGTCGGA TGGAAGACAC CGAGCCCTTC 
TCTGCAGAGC TGCTTTCTGC CATGATGCGG CTCTGGGGCG ACTCAGGAAT CCAAGAGTGC 
TTCAACCGGT CCCGGGAGTA TCAGCTCAAC GACTCTGCCA AATACTACCT GGACAGCCTG 
GATCGGATTG GGGCCGCCGA CTACCAGCCC ACCGAGCAGG ACATCCTCCG AACCAGGGTC 
AAAACCACTG GCATCGTAGA AACCCACTTC ACATTCAAGA ACCTCCACTT CAGGCTGTTT 
GACGTCGGAG GCCAGCGATC TGAACGCAAG AAGTGGATCC ATTGCTTCGA GGACGTCACG 
GCCATCATTT TCTGTGTCGC GCTCAGCGGC TATGACCAGG TGCTCCACGA AGACGAAACC 
ACGAACCGCA TGCACGAATC CCTGAAGCTT TTTGACAGCA TCTGCAACAA CAAATGGTTC 
ACAGACACGT CCATCATCCT GTTTCTTAAC AAGAAGGACA TATTTGAAGA GAAGATCAAG 
AAGTCCCCGC TCACCATCTG CTTTCCTGAA TATACAGGCC CCAGCGCCTT CACAGAAGCC 
GTGGCTTACA TCCAGGCCCA GTACGAGAGC AAGAACAAGT CAGCCCACAA AGAGATCTAC 
ACCCACGTCA CCTGCGCCAC GGACACCAAC AACATCCAGT TTGTCTTTGA TGCTGTGACG 
GACGTCATCA TCGCCAAAAA CCTGCGGGGC TGTGGACTCT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNAO1 ( NM_138736.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_620073.2 Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 2, mRNA.

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CloneID	OHu13628
Clone ID Related Accession (Same CDS sequence)	NM_138736.2 , NM_138736.3
Accession Version	NM_138736.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(o) subunit alpha isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK056008.1, DA529437.1, BC030027.2, AF493895.1, DA115582.1, BX647214.1 and AL512686.1. On Jun 1, 2019 this sequence version replaced NM_138736.2. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) is the same length but has a distinct C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CR936770.1, AF493895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGATGTA CTCTGAGCGC AGAGGAGAGA GCCGCCCTCG AGCGGAGCAA GGCGATTGAG 
AAAAACCTCA AAGAGGATGG CATCAGCGCC GCCAAAGACG TGAAATTACT CCTGCTCGGG 
GCTGGAGAAT CAGGAAAAAG CACCATTGTG AAGCAGATGA AGATCATCCA TGAAGATGGC 
TTCTCCGGAG AAGACGTGAA ACAGTACAAG CCTGTTGTCT ACAGCAACAC TATCCAGTCC 
CTGGCAGCCA TCGTCCGGGC CATGGACACT TTGGGCATCG AATATGGTGA TAAGGAGAGA 
AAGGCTGACG CCAAGATGGT GTGTGATGTG GTGAGTCGGA TGGAAGACAC CGAGCCCTTC 
TCTGCAGAGC TGCTTTCTGC CATGATGCGG CTCTGGGGCG ACTCAGGAAT CCAAGAGTGC 
TTCAACCGGT CCCGGGAGTA TCAGCTCAAC GACTCTGCCA AATACTACCT GGACAGCCTG 
GATCGGATTG GGGCCGCCGA CTACCAGCCC ACCGAGCAGG ACATCCTCCG AACCAGGGTC 
AAAACCACTG GCATCGTAGA AACCCACTTC ACATTCAAGA ACCTCCACTT CAGGCTGTTT 
GACGTCGGAG GCCAGCGATC TGAACGCAAG AAGTGGATCC ATTGCTTCGA GGACGTCACG 
GCCATCATTT TCTGTGTCGC GCTCAGCGGC TATGACCAGG TGCTCCACGA AGACGAAACC 
ACGAACCGCA TGCACGAATC CCTGAAGCTT TTTGACAGCA TCTGCAACAA CAAATGGTTC 
ACAGACACGT CCATCATCCT GTTTCTTAAC AAGAAGGACA TATTTGAAGA GAAGATCAAG 
AAGTCCCCGC TCACCATCTG CTTTCCTGAA TATACAGGCC CCAGCGCCTT CACAGAAGCC 
GTGGCTTACA TCCAGGCCCA GTACGAGAGC AAGAACAAGT CAGCCCACAA AGAGATCTAC 
ACCCACGTCA CCTGCGCCAC GGACACCAAC AACATCCAGT TTGTCTTTGA TGCTGTGACG 
GACGTCATCA TCGCCAAAAA CCTGCGGGGC TGTGGACTCT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620073.2
CDS	748..1812
Translation	MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLKLFDSICNNKWFTDTSIILFLNKKDIFEEKIKKSPLTICFPEYTGPSAFTEAVAYIQAQYESKNKSAHKEIYTHVTCATDTNNIQFVFDAVTDVIIAKNLRGCGLY

Target ORF information:

RefSeq Version	NM_138736.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138736.3

ORF Insert Sequence:

ATGGGATGTA CTCTGAGCGC AGAGGAGAGA GCCGCCCTCG AGCGGAGCAA GGCGATTGAG 
AAAAACCTCA AAGAGGATGG CATCAGCGCC GCCAAAGACG TGAAATTACT CCTGCTCGGG 
GCTGGAGAAT CAGGAAAAAG CACCATTGTG AAGCAGATGA AGATCATCCA TGAAGATGGC 
TTCTCCGGAG AAGACGTGAA ACAGTACAAG CCTGTTGTCT ACAGCAACAC TATCCAGTCC 
CTGGCAGCCA TCGTCCGGGC CATGGACACT TTGGGCATCG AATATGGTGA TAAGGAGAGA 
AAGGCTGACG CCAAGATGGT GTGTGATGTG GTGAGTCGGA TGGAAGACAC CGAGCCCTTC 
TCTGCAGAGC TGCTTTCTGC CATGATGCGG CTCTGGGGCG ACTCAGGAAT CCAAGAGTGC 
TTCAACCGGT CCCGGGAGTA TCAGCTCAAC GACTCTGCCA AATACTACCT GGACAGCCTG 
GATCGGATTG GGGCCGCCGA CTACCAGCCC ACCGAGCAGG ACATCCTCCG AACCAGGGTC 
AAAACCACTG GCATCGTAGA AACCCACTTC ACATTCAAGA ACCTCCACTT CAGGCTGTTT 
GACGTCGGAG GCCAGCGATC TGAACGCAAG AAGTGGATCC ATTGCTTCGA GGACGTCACG 
GCCATCATTT TCTGTGTCGC GCTCAGCGGC TATGACCAGG TGCTCCACGA AGACGAAACC 
ACGAACCGCA TGCACGAATC CCTGAAGCTT TTTGACAGCA TCTGCAACAA CAAATGGTTC 
ACAGACACGT CCATCATCCT GTTTCTTAAC AAGAAGGACA TATTTGAAGA GAAGATCAAG 
AAGTCCCCGC TCACCATCTG CTTTCCTGAA TATACAGGCC CCAGCGCCTT CACAGAAGCC 
GTGGCTTACA TCCAGGCCCA GTACGAGAGC AAGAACAAGT CAGCCCACAA AGAGATCTAC 
ACCCACGTCA CCTGCGCCAC GGACACCAAC AACATCCAGT TTGTCTTTGA TGCTGTGACG 
GACGTCATCA TCGCCAAAAA CCTGCGGGGC TGTGGACTCT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNAO1 ( XM_011523003.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011521305.1 Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant X1, mRNA.

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CloneID	OHu58003
Clone ID Related Accession (Same CDS sequence)	XM_011523003.2 , XM_011523003.3
Accession Version	XM_011523003.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(o) subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011523003.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAAGT TGAATCCTGC AGGGACTACA AGGAGGATCA TCCATGAAGA TGGCTTCTCC 
GGAGAAGACG TGAAACAGTA CAAGCCTGTT GTCTACAGCA ACACTATCCA GTCCCTGGCA 
GCCATCGTCC GGGCCATGGA CACTTTGGGC ATCGAATATG GTGATAAGGA GAGAAAGGCT 
GACGCCAAGA TGGTGTGTGA TGTGGTGAGT CGGATGGAAG ACACCGAGCC CTTCTCTGCA 
GAGCTGCTTT CTGCCATGAT GCGGCTCTGG GGCGACTCAG GAATCCAAGA GTGCTTCAAC 
CGGTCCCGGG AGTATCAGCT CAACGACTCT GCCAAATACT ACCTGGACAG CCTGGATCGG 
ATTGGGGCCG CCGACTACCA GCCCACCGAG CAGGACATCC TCCGAACCAG GGTCAAAACC 
ACTGGCATCG TAGAAACCCA CTTCACATTC AAGAACCTCC ACTTCAGGCT GTTTGACGTC 
GGAGGCCAGC GATCTGAACG CAAGAAGTGG ATCCATTGCT TCGAGGACGT CACGGCCATC 
ATTTTCTGTG TCGCGCTCAG CGGCTATGAC CAGGTGCTCC ACGAAGACGA AACCACGAAC 
CGCATGCACG AGTCTCTCAT GCTCTTCGAC TCCATCTGTA ACAACAAGTT CTTCATCGAT 
ACCTCCATCA TTCTCTTCCT CAACAAGAAA GATCTCTTTG GCGAGAAGAT CAAGAAGTCA 
CCTTTGACCA TCTGCTTTCC TGAATACACA GGCCCCAATA CCTATGAAGA CGCAGCCGCC 
TACATCCAAG CACAATTTGA AAGCAAAAAC CGCTCACCCA ACAAAGAAAT ATATTGTCAC 
ATGACTTGTG CCACAGACAC GAATAACATC CAGGTGGTGT TCGACGCCGT CACCGACATC 
ATCATTGCCA ACAACCTCCG GGGCTGCGGC TTGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011521305.1
CDS	382..1320
Translation	MKKLNPAGTTRRIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY

Target ORF information:

RefSeq Version	XM_011523003.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011523003.2

ORF Insert Sequence:

ATGAAGAAGT TGAATCCTGC AGGGACTACA AGGAGGATCA TCCATGAAGA TGGCTTCTCC 
GGAGAAGACG TGAAACAGTA CAAGCCTGTT GTCTACAGCA ACACTATCCA GTCCCTGGCA 
GCCATCGTCC GGGCCATGGA CACTTTGGGC ATCGAATATG GTGATAAGGA GAGAAAGGCT 
GACGCCAAGA TGGTGTGTGA TGTGGTGAGT CGGATGGAAG ACACCGAGCC CTTCTCTGCA 
GAGCTGCTTT CTGCCATGAT GCGGCTCTGG GGCGACTCAG GAATCCAAGA GTGCTTCAAC 
CGGTCCCGGG AGTATCAGCT CAACGACTCT GCCAAATACT ACCTGGACAG CCTGGATCGG 
ATTGGGGCCG CCGACTACCA GCCCACCGAG CAGGACATCC TCCGAACCAG GGTCAAAACC 
ACTGGCATCG TAGAAACCCA CTTCACATTC AAGAACCTCC ACTTCAGGCT GTTTGACGTC 
GGAGGCCAGC GATCTGAACG CAAGAAGTGG ATCCATTGCT TCGAGGACGT CACGGCCATC 
ATTTTCTGTG TCGCGCTCAG CGGCTATGAC CAGGTGCTCC ACGAAGACGA AACCACGAAC 
CGCATGCACG AGTCTCTCAT GCTCTTCGAC TCCATCTGTA ACAACAAGTT CTTCATCGAT 
ACCTCCATCA TTCTCTTCCT CAACAAGAAA GATCTCTTTG GCGAGAAGAT CAAGAAGTCA 
CCTTTGACCA TCTGCTTTCC TGAATACACA GGCCCCAATA CCTATGAAGA CGCAGCCGCC 
TACATCCAAG CACAATTTGA AAGCAAAAAC CGCTCACCCA ACAAAGAAAT ATATTGTCAC 
ATGACTTGTG CCACAGACAC GAATAACATC CAGGTGGTGT TCGACGCCGT CACCGACATC 
ATCATTGCCA ACAACCTCCG GGGCTGCGGC TTGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GNAO1 ( XM_011523003.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011521305.1 Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu58003
Clone ID Related Accession (Same CDS sequence)	XM_011523003.2 , XM_011523003.3
Accession Version	XM_011523003.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	guanine nucleotide-binding protein G(o) subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011523003.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAAGT TGAATCCTGC AGGGACTACA AGGAGGATCA TCCATGAAGA TGGCTTCTCC 
GGAGAAGACG TGAAACAGTA CAAGCCTGTT GTCTACAGCA ACACTATCCA GTCCCTGGCA 
GCCATCGTCC GGGCCATGGA CACTTTGGGC ATCGAATATG GTGATAAGGA GAGAAAGGCT 
GACGCCAAGA TGGTGTGTGA TGTGGTGAGT CGGATGGAAG ACACCGAGCC CTTCTCTGCA 
GAGCTGCTTT CTGCCATGAT GCGGCTCTGG GGCGACTCAG GAATCCAAGA GTGCTTCAAC 
CGGTCCCGGG AGTATCAGCT CAACGACTCT GCCAAATACT ACCTGGACAG CCTGGATCGG 
ATTGGGGCCG CCGACTACCA GCCCACCGAG CAGGACATCC TCCGAACCAG GGTCAAAACC 
ACTGGCATCG TAGAAACCCA CTTCACATTC AAGAACCTCC ACTTCAGGCT GTTTGACGTC 
GGAGGCCAGC GATCTGAACG CAAGAAGTGG ATCCATTGCT TCGAGGACGT CACGGCCATC 
ATTTTCTGTG TCGCGCTCAG CGGCTATGAC CAGGTGCTCC ACGAAGACGA AACCACGAAC 
CGCATGCACG AGTCTCTCAT GCTCTTCGAC TCCATCTGTA ACAACAAGTT CTTCATCGAT 
ACCTCCATCA TTCTCTTCCT CAACAAGAAA GATCTCTTTG GCGAGAAGAT CAAGAAGTCA 
CCTTTGACCA TCTGCTTTCC TGAATACACA GGCCCCAATA CCTATGAAGA CGCAGCCGCC 
TACATCCAAG CACAATTTGA AAGCAAAAAC CGCTCACCCA ACAAAGAAAT ATATTGTCAC 
ATGACTTGTG CCACAGACAC GAATAACATC CAGGTGGTGT TCGACGCCGT CACCGACATC 
ATCATTGCCA ACAACCTCCG GGGCTGCGGC TTGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011521305.1
CDS	372..1310
Translation	MKKLNPAGTTRRIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY

Target ORF information:

RefSeq Version	XM_011523003.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011523003.3

ORF Insert Sequence:

ATGAAGAAGT TGAATCCTGC AGGGACTACA AGGAGGATCA TCCATGAAGA TGGCTTCTCC 
GGAGAAGACG TGAAACAGTA CAAGCCTGTT GTCTACAGCA ACACTATCCA GTCCCTGGCA 
GCCATCGTCC GGGCCATGGA CACTTTGGGC ATCGAATATG GTGATAAGGA GAGAAAGGCT 
GACGCCAAGA TGGTGTGTGA TGTGGTGAGT CGGATGGAAG ACACCGAGCC CTTCTCTGCA 
GAGCTGCTTT CTGCCATGAT GCGGCTCTGG GGCGACTCAG GAATCCAAGA GTGCTTCAAC 
CGGTCCCGGG AGTATCAGCT CAACGACTCT GCCAAATACT ACCTGGACAG CCTGGATCGG 
ATTGGGGCCG CCGACTACCA GCCCACCGAG CAGGACATCC TCCGAACCAG GGTCAAAACC 
ACTGGCATCG TAGAAACCCA CTTCACATTC AAGAACCTCC ACTTCAGGCT GTTTGACGTC 
GGAGGCCAGC GATCTGAACG CAAGAAGTGG ATCCATTGCT TCGAGGACGT CACGGCCATC 
ATTTTCTGTG TCGCGCTCAG CGGCTATGAC CAGGTGCTCC ACGAAGACGA AACCACGAAC 
CGCATGCACG AGTCTCTCAT GCTCTTCGAC TCCATCTGTA ACAACAAGTT CTTCATCGAT 
ACCTCCATCA TTCTCTTCCT CAACAAGAAA GATCTCTTTG GCGAGAAGAT CAAGAAGTCA 
CCTTTGACCA TCTGCTTTCC TGAATACACA GGCCCCAATA CCTATGAAGA CGCAGCCGCC 
TACATCCAAG CACAATTTGA AAGCAAAAAC CGCTCACCCA ACAAAGAAAT ATATTGTCAC 
ATGACTTGTG CCACAGACAC GAATAACATC CAGGTGGTGT TCGACGCCGT CACCGACATC 
ATCATTGCCA ACAACCTCCG GGGCTGCGGC TTGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expanding Phenotype of De Novo Mutations in GNAO1: Four New Cases and Review of Literature.
Neuropediatrics48(5)371-377(2017 10)
Schorling DC,Dietel T,Evers C,Hinderhofer K,Korinthenberg R,Ezzo D,B?nnemann CG,Kirschner J

Movement disorder in
Neurology89(8)762-770(2017 Aug)
Feng H,Sj?gren B,Karaj B,Shaw V,Gezer A,Neubig RR

GNAO1-associated epileptic encephalopathy and movement disorders: c.607G>A variant represents a probable mutation hotspot with a distinct phenotype.
Epileptic disorders : international epilepsy journal with videotape19(1)67-75(2017 Mar)
Arya R,Spaeth C,Gilbert DL,Leach JL,Holland KD

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GNAO1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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