GLRX cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GLRX
Entrez Gene ID	2745
Full Name	glutaredoxin
Synonyms	GRX,GRX1
General protein information	Preferred Names glutaredoxin Names glutaredoxin-1 TTase-1 thioltransferase thioltransferase-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q15
Summary	This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011].
Disorder MIM:	600443

mRNA and Protein(s)

mRNA	Protein	Name
NM_001243659.1	NP_001230588.1	glutaredoxin-1
NM_002064.3	NP_002055.1	glutaredoxin-1
NM_001243658.2	NP_001230587.1	glutaredoxin-1
NM_001118890.1	NP_001112362.1	glutaredoxin-1
NM_002064.2	NP_002055.1	glutaredoxin-1
NM_001243658.1	NP_001230587.1	glutaredoxin-1
NM_001118890.2	NP_001112362.1	glutaredoxin-1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GLRX	XP_851559.1
	GLRX	XP_001093482.1
Bos taurus (cattle)	LOC101902340	XP_005217293.1
Rattus norvegicus (Norway rat)	Glrx	NP_071614.1
Homo sapiens (human)	GLRX	NP_001230588.1
Pan troglodytes (chimpanzee)	GLRX	NP_001182153.1
Bos taurus (cattle)	LOC101904049	XP_005219631.1
Danio rerio (zebrafish)	glrx	NP_001005942.1
Xenopus tropicalis (tropical clawed frog)	glrx	NP_001016597.1
Bos taurus (cattle)	GLRX	NP_001032693.1
Bos taurus (cattle)	LOC101904371	XP_005219633.1
Mus musculus (house mouse)	Glrx	NP_444338.2
Gallus gallus (chicken)	GLRX	NP_990491.1
Caenorhabditis elegans (roundworm)	glrx-10	NP_490812.1

Gene Ontology
Bibliography

Related articles in PubMed

Glutaredoxin-1 silencing induces cell senescence via p53/p21/p16 signaling axis.
Yang F, Yi M, Liu Y, Wang Q, Hu Y, Deng H
Journal of proteome research(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes
Title: Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes.

GRX1 overexpression constrains oxidative stress and apoptosis in osteoarthritis chondrocytes by regulating CREB/HO-1, providing a novel insight into the molecular mechanism and potential treatment of osteoarthritis.
Title: Glutaredoxin 1 (GRX1) inhibits oxidative stress and apoptosis of chondrocytes by regulating CREB/HO-1 in osteoarthritis.

Based on the roGFP2-hGrx1 signals, glutathione-dependent redox potentials of -267mV and -328mV, respectively, were obtained. Employing these novel tools, initial studies on the effects of redox-active agents and clinically employed antimalarial drugs were carried out on both organelles.
Title: Determination of glutathione redox potential and pH value in subcellular compartments of malaria parasites.

Glutaredoxin desensitizes lens to oxidative stress by connecting and integrating specific signaling and transcriptional regulation for antioxidant response.
Title: Glutaredoxin Desensitizes Lens to Oxidative Stress by Connecting and Integrating Specific Signaling and Transcriptional Regulation for Antioxidant Response.

Overexpression of NOS3 increased the levels and activities of proteins of the redoxin systems, Trx1, Grx1, TrxR1 and TxnIP, and the levels of signaling proteins (Akt1, pAkt1(-)Ser473, MapK, pMapK, Stat3, Fas).
Title: Redox Regulation Of Metabolic And Signaling Pathways By Thioredoxin And Glutaredoxin In Nitric Oxide Treated Hepatoblastoma Cells.

The following GLRX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GLRX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01109	NM_001243659.1 Latest version!	Homo sapiens glutaredoxin (GLRX), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01109	NM_002064.3 Latest version!	Homo sapiens glutaredoxin (GLRX), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01109	NM_001243658.2 Latest version!	Homo sapiens glutaredoxin (GLRX), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01109	NM_001118890.2 Latest version!	Homo sapiens glutaredoxin (GLRX), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu01109	NM_002064.2	Homo sapiens glutaredoxin (GLRX), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01109	NM_001243658.1	Homo sapiens glutaredoxin (GLRX), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01109	NM_001118890.1	Homo sapiens glutaredoxin (GLRX), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GLRX ( NM_001243659.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230588.1 Homo sapiens glutaredoxin (GLRX), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu01109
Clone ID Related Accession (Same CDS sequence)	NM_001243659.1 , NM_002064.3 , NM_001243658.2 , NM_001118890.1 , NM_002064.2 , NM_001243658.1 , NM_001118890.2
Accession Version	NM_001243659.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	glutaredoxin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP196332.1, BU949348.1, AA485178.1 and AC008821.6. Transcript Variant: This variant (4) differs in the 3' UTR, compared to variant 1. Variants 1-4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.366893.1, SRR1163657.261846.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230588.1
CDS	212..532
Translation	MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ

Target ORF information:

RefSeq Version	NM_001243659.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glutaredoxin (GLRX), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243659.1

ORF Insert Sequence:

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRX ( NM_002064.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002055.1 Homo sapiens glutaredoxin (GLRX), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01109
Clone ID Related Accession (Same CDS sequence)	NM_001243659.1 , NM_002064.3 , NM_001243658.2 , NM_001118890.1 , NM_002064.2 , NM_001243658.1 , NM_001118890.2
Accession Version	NM_002064.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	glutaredoxin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP196332.1, BC010965.1, BX106369.1, BE738446.1, D21238.1, AW792936.1 and AW128930.1. This sequence is a reference standard in the RefSeqGene project. On May 31, 2019 this sequence version replaced NM_002064.2. Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.371559.1, SRR1163657.290471.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002055.1
CDS	65..385
Translation	MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ

Target ORF information:

RefSeq Version	NM_002064.3
Organism	Homo sapiens(human)
Definition	Homo sapiens glutaredoxin (GLRX), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002064.3

ORF Insert Sequence:

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRX ( NM_001243658.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230587.1 Homo sapiens glutaredoxin (GLRX), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu01109
Clone ID Related Accession (Same CDS sequence)	NM_001243659.1 , NM_002064.3 , NM_001243658.2 , NM_001118890.1 , NM_002064.2 , NM_001243658.1 , NM_001118890.2
Accession Version	NM_001243658.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	glutaredoxin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG547098.1 and AC008821.6. On May 31, 2019 this sequence version replaced NM_001243658.1. Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1. Variants 1-4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG547098.1, BP360349.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230587.1
CDS	65..385
Translation	MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ

Target ORF information:

RefSeq Version	NM_001243658.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glutaredoxin (GLRX), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243658.2

ORF Insert Sequence:

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRX ( NM_001118890.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001112362.1 Homo sapiens glutaredoxin (GLRX), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01109
Clone ID Related Accession (Same CDS sequence)	NM_001243659.1 , NM_002064.3 , NM_001243658.2 , NM_001118890.1 , NM_002064.2 , NM_001243658.1 , NM_001118890.2
Accession Version	NM_001118890.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	glutaredoxin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP196332.1, BC010965.1, D21238.1, AW792936.1 and AW128930.1. Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1-4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.179506.1, SRR1163658.350451.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001112362.1
CDS	212..532
Translation	MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ

Target ORF information:

RefSeq Version	NM_001118890.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glutaredoxin (GLRX), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001118890.1

ORF Insert Sequence:

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRX ( NM_002064.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002055.1 Homo sapiens glutaredoxin (GLRX), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01109
Clone ID Related Accession (Same CDS sequence)	NM_001243659.1 , NM_002064.3 , NM_001243658.2 , NM_001118890.1 , NM_002064.2 , NM_001243658.1 , NM_001118890.2
Accession Version	NM_002064.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Homo sapiens(human)
Product	glutaredoxin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP196332.1, BC010965.1, BX106369.1, BE738446.1, D21238.1, AW792936.1 and AW128930.1. This sequence is a reference standard in the RefSeqGene project. On Mar 7, 2008 this sequence version replaced NM_002064.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.371559.1, SRR1163657.290471.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002055.1
CDS	212..532
Translation	MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ

Target ORF information:

RefSeq Version	NM_002064.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glutaredoxin (GLRX), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002064.2

ORF Insert Sequence:

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRX ( NM_001243658.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230587.1 Homo sapiens glutaredoxin (GLRX), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu01109
Clone ID Related Accession (Same CDS sequence)	NM_001243659.1 , NM_002064.3 , NM_001243658.2 , NM_001118890.1 , NM_002064.2 , NM_001243658.1 , NM_001118890.2
Accession Version	NM_001243658.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Homo sapiens(human)
Product	glutaredoxin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP196332.1, BG547098.1 and AC008821.6. Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1. Variants 1-4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279830.7049.1, ERR279869.3510.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230587.1
CDS	212..532
Translation	MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ

Target ORF information:

RefSeq Version	NM_001243658.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glutaredoxin (GLRX), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243658.1

ORF Insert Sequence:

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLRX ( NM_001118890.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001112362.1 Homo sapiens glutaredoxin (GLRX), transcript variant 2, mRNA.

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CloneID	OHu01109
Clone ID Related Accession (Same CDS sequence)	NM_001243659.1 , NM_002064.3 , NM_001243658.2 , NM_001118890.1 , NM_002064.2 , NM_001243658.1 , NM_001118890.2
Accession Version	NM_001118890.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	glutaredoxin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP196332.1, BC010965.1, D21238.1, AW792936.1 and AW128930.1. On Nov 22, 2018 this sequence version replaced NM_001118890.1. Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1-4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.64138.1, SRR5189667.252130.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000237858.11/ ENSP00000237858.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001112362.1
CDS	65..385
Translation	MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ

Target ORF information:

RefSeq Version	NM_001118890.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glutaredoxin (GLRX), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001118890.2

ORF Insert Sequence:

ATGGCTCAAG AGTTTGTGAA CTGCAAAATC CAGCCTGGGA AGGTGGTTGT GTTCATCAAG 
CCCACCTGCC CGTACTGCAG GAGGGCCCAA GAGATCCTCA GTCAATTGCC CATCAAACAA 
GGGCTTCTGG AATTTGTCGA TATCACAGCC ACCAACCACA CTAACGAGAT TCAAGATTAT 
TTGCAACAGC TCACGGGAGC AAGAACGGTG CCTCGAGTCT TTATTGGTAA AGATTGTATA 
GGCGGATGCA GTGATCTAGT CTCTTTGCAA CAGAGTGGGG AACTGCTGAC GCGGCTAAAG 
CAGATTGGAG CTCTGCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glutaredoxin-1 silencing induces cell senescence via p53/p21/p16 signaling axis.
Journal of proteome research(2018 Jan)
Yang F,Yi M,Liu Y,Wang Q,Hu Y,Deng H

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GLRX cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

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ORF Insert Sequence:

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ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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