HTRA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HTRA2
Entrez Gene ID	27429
Full Name	HtrA serine peptidase 2
Synonyms	MGCA8,OMI,PARK13,PRSS25
General protein information	Preferred Names HtrA serine peptidase 2 Names serine protease HTRA2, mitochondrial HtrA-like serine protease Omi stress-regulated endoprotease high temperature requirement protein A2 protease, serine, 25 serine protease 25 serine proteinase OMI
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.1
Summary	This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
Disorder MIM:	606441
Disorder Html:	{Parkinson disease 13}, 610297 (3); 3-methylglutaconic aciduria, type VIII, 617248 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_013247.4	NP_037379.1	serine protease HTRA2, mitochondrial isoform 1 preproprotein
NM_001321728.1	NP_001308657.1	serine protease HTRA2, mitochondrial isoform 4 preproprotein
NM_013247.5	NP_037379.1	serine protease HTRA2, mitochondrial isoform 1 preproprotein
NM_145074.2	NP_659540.1	serine protease HTRA2, mitochondrial isoform 2 preproprotein
NM_001321727.1	NP_001308656.1	serine protease HTRA2, mitochondrial isoform 3 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	HTRA2	NP_037379.1
Pan troglodytes (chimpanzee)	HTRA2	XP_003309140.2
Canis lupus familiaris (dog)	HTRA2	XP_532992.3
Danio rerio (zebrafish)	LOC560917	XP_002663637.2
Danio rerio (zebrafish)	zgc:173425	NP_001098612.1
Danio rerio (zebrafish)	si:busm1-sl7.7	XP_003199743.1
Danio rerio (zebrafish)	LOC100003308	NP_001103205.1
Danio rerio (zebrafish)	LOC799006	XP_001339411.5
Danio rerio (zebrafish)	si:dkey-84o3.3	XP_002665896.3
Bos taurus (cattle)	HTRA2	NP_001071424.1
Gallus gallus (chicken)	HTRA2	XP_423666.3
Danio rerio (zebrafish)	LOC100536969	XP_003199752.2
Danio rerio (zebrafish)	si:dkey-84o3.7	XP_001335201.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000240	XP_310886.5
Danio rerio (zebrafish)	zgc:174193	NP_001108178.1
Danio rerio (zebrafish)	si:dkey-33c12.10	XP_003199749.2
Danio rerio (zebrafish)	si:dkey-33c12.2	XP_005172803.1
Danio rerio (zebrafish)	LOC100329860	XP_002664149.3
Danio rerio (zebrafish)	LOC797876	XP_001923767.4
Danio rerio (zebrafish)	LOC100331049	XP_002665901.2
Danio rerio (zebrafish)	LOC799537	NP_001103640.1
Rattus norvegicus (Norway rat)	Htra2	NP_001100069.1
Danio rerio (zebrafish)	LOC100149563	NP_001122292.1
Danio rerio (zebrafish)	LOC797799	NP_001103998.1
Drosophila melanogaster (fruit fly)	HtrA2	NP_001262565.1
	HTRA2	XP_001110803.1
Mus musculus (house mouse)	Htra2	NP_062726.3
Danio rerio (zebrafish)	LOC793110	XP_001332804.5
Danio rerio (zebrafish)	LOC793521	XP_001333305.1
Danio rerio (zebrafish)	LOC100330919	XP_005161042.1

Gene Ontology
Bibliography

Related articles in PubMed

Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes.
Sun ML, Sun LM, Wang YQ
Journal of molecular recognition : JMR(2017 Dec)

Ovarian serous carcinomas acquire cisplatin resistance and increased invasion through downregulation of the high-temperature-required protein A2 (HtrA2), following repeated treatment with cisplatin.
Soyama H, Miyamoto M, Takano M, Aoyama T, Matsuura H, Sakamoto T, Takasaki K, Kuwahara M, Kato K, Yoshikawa T, Iwahashi H, Tsuda H, Furuya K
Medical oncology (Northwood, London, England)34(12)201(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The important functions for HTRA2 in programmed cell death.
Title: Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria.

A pathogenic role of serine protease HtrA2 in Parkinson's and Alzheimer's diseases has been described. (Review)
Title: Pathogenic Role of Serine Protease HtrA2/Omi in Neurodegenerative Diseases.

HTRA2 and ANO3 mutations are not common causes of essential tremor
Title: A step toward essential tremor gene discovery: identification of extreme phenotype and screening of HTRA2 and ANO3.

The first report of recessive deleterious mutations in HTRA2 in human. Absence of HTRA2/Omi is associated with severe neurodegenerative disorder of infancy, abnormal mitochondria, 3-methylglutaconic aciduria and increased sensitivity to apoptosis.
Title: Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria.

The a5 helix of PDZ was involved in both, the intra- and intersubunit changes of interactions and thus seems to play an important role in HtrA2 activation.
Title: Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer.

The following HTRA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HTRA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18013	NM_013247.5 Latest version!	Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu101229	NM_001321727.1 Latest version!	Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu16180	NM_145074.2 Latest version!	Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu35363	NM_001321728.1 Latest version!	Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu18013	NM_013247.4	Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HTRA2 ( NM_013247.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037379.1 Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18013
Clone ID Related Accession (Same CDS sequence)	NM_013247.4 , NM_013247.5
Accession Version	NM_013247.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-01
Organism	Homo sapiens(human)
Product	serine protease HTRA2, mitochondrial isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF141305.1 and BF939362.1. This sequence is a reference standard in the RefSeqGene project. On Aug 24, 2005 this sequence version replaced NM_013247.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF141305.1, SRR1163658.206662.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGC CGAGGGCGGG GCGGGGTGCA GGCTGGAGCC TTCGGGCATG GCGGGCTTTG 
GGGGGCATTC GCTGGGGGAG GAGACCCCGT TTGACCCCTG ACCTCCGGGC CCTGCTGACG 
TCAGGAACTT CTGACCCCCG GGCCCGAGTG ACTTATGGGA CCCCCAGTCT CTGGGCCCGG 
TTGTCTGTTG GGGTCACTGA ACCCCGAGCA TGCCTGACGT CTGGGACCCC GGGTCCCCGG 
GCACAACTGA CTGCGGTGAC CCCAGATACC AGGACCCGGG AGGCCTCAGA GAACTCTGGA 
ACCCGTTCGC GCGCGTGGCT GGCGGTGGCG CTGGGCGCTG GGGGGGCAGT GCTGTTGTTG 
TTGTGGGGCG GGGGTCGGGG TCCTCCGGCC GTCCTCGCCG CCGTCCCTAG CCCGCCGCCC 
GCTTCTCCCC GGAGTCAGTA CAACTTCATC GCAGATGTGG TGGAGAAGAC AGCACCTGCC 
GTGGTCTATA TCGAGATCCT GGACCGGCAC CCTTTCTTGG GCCGCGAGGT CCCTATCTCG 
AACGGCTCAG GATTCGTGGT GGCTGCCGAT GGGCTCATTG TCACCAACGC CCATGTGGTG 
GCTGATCGGC GCAGAGTCCG TGTGAGACTG CTAAGCGGCG ACACGTATGA GGCCGTGGTC 
ACAGCTGTGG ATCCCGTGGC AGACATCGCA ACGCTGAGGA TTCAGACTAA GGAGCCTCTC 
CCCACGCTGC CTCTGGGACG CTCAGCTGAT GTCCGGCAAG GGGAGTTTGT TGTTGCCATG 
GGAAGTCCCT TTGCACTGCA GAACACGATC ACATCCGGCA TTGTTAGCTC TGCTCAGCGT 
CCAGCCAGAG ACCTGGGACT CCCCCAAACC AATGTGGAAT ACATTCAAAC TGATGCAGCT 
ATTGATTTTG GAAACTCTGG AGGTCCCCTG GTTAACCTGG ATGGGGAGGT GATTGGAGTG 
AACACCATGA AGGTCACAGC TGGAATCTCC TTTGCCATCC CTTCTGATCG TCTTCGAGAG 
TTTCTGCATC GTGGGGAAAA GAAGAATTCC TCCTCCGGAA TCAGTGGGTC CCAGCGGCGC 
TACATTGGGG TGATGATGCT GACCCTGAGT CCCAGCATCC TTGCTGAACT ACAGCTTCGA 
GAACCAAGCT TTCCCGATGT TCAGCATGGT GTACTCATCC ATAAAGTCAT CCTGGGCTCC 
CCTGCACACC GGGCTGGTCT GCGGCCTGGT GATGTGATTT TGGCCATTGG GGAGCAGATG 
GTACAAAATG CTGAAGATGT TTATGAAGCT GTTCGAACCC AATCCCAGTT GGCAGTGCAG 
ATCCGGCGGG GACGAGAAAC ACTGACCTTA TATGTGACCC CTGAGGTCAC AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037379.1
CDS	603..1979
Translation	MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE

Target ORF information:

RefSeq Version	NM_013247.4
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013247.4

ORF Insert Sequence:

ATGGCTGCGC CGAGGGCGGG GCGGGGTGCA GGCTGGAGCC TTCGGGCATG GCGGGCTTTG 
GGGGGCATTC GCTGGGGGAG GAGACCCCGT TTGACCCCTG ACCTCCGGGC CCTGCTGACG 
TCAGGAACTT CTGACCCCCG GGCCCGAGTG ACTTATGGGA CCCCCAGTCT CTGGGCCCGG 
TTGTCTGTTG GGGTCACTGA ACCCCGAGCA TGCCTGACGT CTGGGACCCC GGGTCCCCGG 
GCACAACTGA CTGCGGTGAC CCCAGATACC AGGACCCGGG AGGCCTCAGA GAACTCTGGA 
ACCCGTTCGC GCGCGTGGCT GGCGGTGGCG CTGGGCGCTG GGGGGGCAGT GCTGTTGTTG 
TTGTGGGGCG GGGGTCGGGG TCCTCCGGCC GTCCTCGCCG CCGTCCCTAG CCCGCCGCCC 
GCTTCTCCCC GGAGTCAGTA CAACTTCATC GCAGATGTGG TGGAGAAGAC AGCACCTGCC 
GTGGTCTATA TCGAGATCCT GGACCGGCAC CCTTTCTTGG GCCGCGAGGT CCCTATCTCG 
AACGGCTCAG GATTCGTGGT GGCTGCCGAT GGGCTCATTG TCACCAACGC CCATGTGGTG 
GCTGATCGGC GCAGAGTCCG TGTGAGACTG CTAAGCGGCG ACACGTATGA GGCCGTGGTC 
ACAGCTGTGG ATCCCGTGGC AGACATCGCA ACGCTGAGGA TTCAGACTAA GGAGCCTCTC 
CCCACGCTGC CTCTGGGACG CTCAGCTGAT GTCCGGCAAG GGGAGTTTGT TGTTGCCATG 
GGAAGTCCCT TTGCACTGCA GAACACGATC ACATCCGGCA TTGTTAGCTC TGCTCAGCGT 
CCAGCCAGAG ACCTGGGACT CCCCCAAACC AATGTGGAAT ACATTCAAAC TGATGCAGCT 
ATTGATTTTG GAAACTCTGG AGGTCCCCTG GTTAACCTGG ATGGGGAGGT GATTGGAGTG 
AACACCATGA AGGTCACAGC TGGAATCTCC TTTGCCATCC CTTCTGATCG TCTTCGAGAG 
TTTCTGCATC GTGGGGAAAA GAAGAATTCC TCCTCCGGAA TCAGTGGGTC CCAGCGGCGC 
TACATTGGGG TGATGATGCT GACCCTGAGT CCCAGCATCC TTGCTGAACT ACAGCTTCGA 
GAACCAAGCT TTCCCGATGT TCAGCATGGT GTACTCATCC ATAAAGTCAT CCTGGGCTCC 
CCTGCACACC GGGCTGGTCT GCGGCCTGGT GATGTGATTT TGGCCATTGG GGAGCAGATG 
GTACAAAATG CTGAAGATGT TTATGAAGCT GTTCGAACCC AATCCCAGTT GGCAGTGCAG 
ATCCGGCGGG GACGAGAAAC ACTGACCTTA TATGTGACCC CTGAGGTCAC AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA2 ( NM_013247.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_037379.1 Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18013
Clone ID Related Accession (Same CDS sequence)	NM_013247.4 , NM_013247.5
Accession Version	NM_013247.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-02
Organism	Homo sapiens(human)
Product	serine protease HTRA2, mitochondrial isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF141305.1 and BF939362.1. This sequence is a reference standard in the RefSeqGene project. On Dec 23, 2019 this sequence version replaced NM_013247.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000096.2, AF141305.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGC CGAGGGCGGG GCGGGGTGCA GGCTGGAGCC TTCGGGCATG GCGGGCTTTG 
GGGGGCATTC GCTGGGGGAG GAGACCCCGT TTGACCCCTG ACCTCCGGGC CCTGCTGACG 
TCAGGAACTT CTGACCCCCG GGCCCGAGTG ACTTATGGGA CCCCCAGTCT CTGGGCCCGG 
TTGTCTGTTG GGGTCACTGA ACCCCGAGCA TGCCTGACGT CTGGGACCCC GGGTCCCCGG 
GCACAACTGA CTGCGGTGAC CCCAGATACC AGGACCCGGG AGGCCTCAGA GAACTCTGGA 
ACCCGTTCGC GCGCGTGGCT GGCGGTGGCG CTGGGCGCTG GGGGGGCAGT GCTGTTGTTG 
TTGTGGGGCG GGGGTCGGGG TCCTCCGGCC GTCCTCGCCG CCGTCCCTAG CCCGCCGCCC 
GCTTCTCCCC GGAGTCAGTA CAACTTCATC GCAGATGTGG TGGAGAAGAC AGCACCTGCC 
GTGGTCTATA TCGAGATCCT GGACCGGCAC CCTTTCTTGG GCCGCGAGGT CCCTATCTCG 
AACGGCTCAG GATTCGTGGT GGCTGCCGAT GGGCTCATTG TCACCAACGC CCATGTGGTG 
GCTGATCGGC GCAGAGTCCG TGTGAGACTG CTAAGCGGCG ACACGTATGA GGCCGTGGTC 
ACAGCTGTGG ATCCCGTGGC AGACATCGCA ACGCTGAGGA TTCAGACTAA GGAGCCTCTC 
CCCACGCTGC CTCTGGGACG CTCAGCTGAT GTCCGGCAAG GGGAGTTTGT TGTTGCCATG 
GGAAGTCCCT TTGCACTGCA GAACACGATC ACATCCGGCA TTGTTAGCTC TGCTCAGCGT 
CCAGCCAGAG ACCTGGGACT CCCCCAAACC AATGTGGAAT ACATTCAAAC TGATGCAGCT 
ATTGATTTTG GAAACTCTGG AGGTCCCCTG GTTAACCTGG ATGGGGAGGT GATTGGAGTG 
AACACCATGA AGGTCACAGC TGGAATCTCC TTTGCCATCC CTTCTGATCG TCTTCGAGAG 
TTTCTGCATC GTGGGGAAAA GAAGAATTCC TCCTCCGGAA TCAGTGGGTC CCAGCGGCGC 
TACATTGGGG TGATGATGCT GACCCTGAGT CCCAGCATCC TTGCTGAACT ACAGCTTCGA 
GAACCAAGCT TTCCCGATGT TCAGCATGGT GTACTCATCC ATAAAGTCAT CCTGGGCTCC 
CCTGCACACC GGGCTGGTCT GCGGCCTGGT GATGTGATTT TGGCCATTGG GGAGCAGATG 
GTACAAAATG CTGAAGATGT TTATGAAGCT GTTCGAACCC AATCCCAGTT GGCAGTGCAG 
ATCCGGCGGG GACGAGAAAC ACTGACCTTA TATGTGACCC CTGAGGTCAC AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037379.1
CDS	75..1451
Translation	MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE

Target ORF information:

RefSeq Version	NM_013247.5
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013247.5

ORF Insert Sequence:

ATGGCTGCGC CGAGGGCGGG GCGGGGTGCA GGCTGGAGCC TTCGGGCATG GCGGGCTTTG 
GGGGGCATTC GCTGGGGGAG GAGACCCCGT TTGACCCCTG ACCTCCGGGC CCTGCTGACG 
TCAGGAACTT CTGACCCCCG GGCCCGAGTG ACTTATGGGA CCCCCAGTCT CTGGGCCCGG 
TTGTCTGTTG GGGTCACTGA ACCCCGAGCA TGCCTGACGT CTGGGACCCC GGGTCCCCGG 
GCACAACTGA CTGCGGTGAC CCCAGATACC AGGACCCGGG AGGCCTCAGA GAACTCTGGA 
ACCCGTTCGC GCGCGTGGCT GGCGGTGGCG CTGGGCGCTG GGGGGGCAGT GCTGTTGTTG 
TTGTGGGGCG GGGGTCGGGG TCCTCCGGCC GTCCTCGCCG CCGTCCCTAG CCCGCCGCCC 
GCTTCTCCCC GGAGTCAGTA CAACTTCATC GCAGATGTGG TGGAGAAGAC AGCACCTGCC 
GTGGTCTATA TCGAGATCCT GGACCGGCAC CCTTTCTTGG GCCGCGAGGT CCCTATCTCG 
AACGGCTCAG GATTCGTGGT GGCTGCCGAT GGGCTCATTG TCACCAACGC CCATGTGGTG 
GCTGATCGGC GCAGAGTCCG TGTGAGACTG CTAAGCGGCG ACACGTATGA GGCCGTGGTC 
ACAGCTGTGG ATCCCGTGGC AGACATCGCA ACGCTGAGGA TTCAGACTAA GGAGCCTCTC 
CCCACGCTGC CTCTGGGACG CTCAGCTGAT GTCCGGCAAG GGGAGTTTGT TGTTGCCATG 
GGAAGTCCCT TTGCACTGCA GAACACGATC ACATCCGGCA TTGTTAGCTC TGCTCAGCGT 
CCAGCCAGAG ACCTGGGACT CCCCCAAACC AATGTGGAAT ACATTCAAAC TGATGCAGCT 
ATTGATTTTG GAAACTCTGG AGGTCCCCTG GTTAACCTGG ATGGGGAGGT GATTGGAGTG 
AACACCATGA AGGTCACAGC TGGAATCTCC TTTGCCATCC CTTCTGATCG TCTTCGAGAG 
TTTCTGCATC GTGGGGAAAA GAAGAATTCC TCCTCCGGAA TCAGTGGGTC CCAGCGGCGC 
TACATTGGGG TGATGATGCT GACCCTGAGT CCCAGCATCC TTGCTGAACT ACAGCTTCGA 
GAACCAAGCT TTCCCGATGT TCAGCATGGT GTACTCATCC ATAAAGTCAT CCTGGGCTCC 
CCTGCACACC GGGCTGGTCT GCGGCCTGGT GATGTGATTT TGGCCATTGG GGAGCAGATG 
GTACAAAATG CTGAAGATGT TTATGAAGCT GTTCGAACCC AATCCCAGTT GGCAGTGCAG 
ATCCGGCGGG GACGAGAAAC ACTGACCTTA TATGTGACCC CTGAGGTCAC AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA2 ( NM_001321727.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001308656.1 Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu101229
Clone ID Related Accession (Same CDS sequence)	NM_001321727.1
Accession Version	NM_001321727.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1311bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	serine protease HTRA2, mitochondrial isoform 3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005041.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF141306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCTGCGC CGAGGGCGGG GCGGGGTGCA GGCTGGAGCC TTCGGGCATG GCGGGCTTTG 
GGGGGCATTC GCTGGGGGAG GAGACCCCGT TTGACCCCTG ACCTCCGGGC CCTGCTGACG 
TCAGGAACTT CTGACCCCCG GGCCCGAGTG ACTTATGGGA CCCCCAGTCT CTGGGCCCGG 
TTGTCTGTTG GGGTCACTGA ACCCCGAGCA TGCCTGACGT CTGGGACCCC GGGTCCCCGG 
GCACAACTGA CTGCGGTGAC CCCAGATACC AGGACCCGGG AGGCCTCAGA GAACTCTGGA 
ACCCGTTCGC GCGCGTGGCT GGCGGTGGCG CTGGGCGCTG GGGGGGCAGT GCTGTTGTTG 
TTGTGGGGCG GGGGTCGGGG TCCTCCGGCC GTCCTCGCCG CCGTCCCTAG CCCGCCGCCC 
GCTTCTCCCC GGAGTCAGTA CAACTTCATC GCAGATGTGG TGGAGAAGAC AGCACCTGCC 
GTGGTCTATA TCGAGATCCT GGACCGGCAC CCTTTCTTGG GCCGCGAGGT CCCTATCTCG 
AACGGCTCAG GATTCGTGGT GGCTGCCGAT GGGCTCATTG TCACCAACGC CCATGTGGTG 
GCTGATCGGC GCAGAGTCCG TGTGAGACTG CTAAGCGGCG ACACGTATGA GGCCGTGGTC 
ACAGCTGTGG ATCCCGTGGC AGACATCGCA ACGCTGAGGA TTCAGACTAA GGAGCCTCTC 
CCCACGCTGC CTCTGGGACG CTCAGCTGAT GTCCGGCAAG GGGAGTTTGT TGTTGCCATG 
GGAAGTCCCT TTGCACTGCA GAACACGATC ACATCCGGCA TTGTTAGCTC TGCTCAGCGT 
CCAGCCAGAG ACCTGGGACT CCCCCAAACC AATGTGGAAT ACATTCAAAC TGATGCAGCT 
ATTGATTTTG GAAACTCTGG AGGTCCCCTG GTTAACCTGG CTAGGGAACT GGGGGCTGTA 
TCCCTGCAGG ATGGGGAGGT GATTGGAGTG AACACCATGA AGGTCACAGC TGGAATCTCC 
TTTGCCATCC CTTCTGATCG TCTTCGAGAG TTTCTGCATC GTGGGGAAAA GAAGAATTCC 
TCCTCCGGAA TCAGTGGGTC CCAGCGGCGC TACATTGGGG TGATGATGCT GACCCTGAGT 
CCCAGGGCTG GTCTGCGGCC TGGTGATGTG ATTTTGGCCA TTGGGGAGCA GATGGTACAA 
AATGCTGAAG ATGTTTATGA AGCTGTTCGA ACCCAATCCC AGTTGGCAGT GCAGATCCGG 
CGGGGACGAG AAACACTGAC CTTATATGTG ACCCCTGAGG TCACAGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001308656.1
CDS	603..1913
Translation	MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLARELGAVSLQDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE

Target ORF information:

RefSeq Version	NM_001321727.1
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001321727.1

ORF Insert Sequence:

ATGGCTGCGC CGAGGGCGGG GCGGGGTGCA GGCTGGAGCC TTCGGGCATG GCGGGCTTTG 
GGGGGCATTC GCTGGGGGAG GAGACCCCGT TTGACCCCTG ACCTCCGGGC CCTGCTGACG 
TCAGGAACTT CTGACCCCCG GGCCCGAGTG ACTTATGGGA CCCCCAGTCT CTGGGCCCGG 
TTGTCTGTTG GGGTCACTGA ACCCCGAGCA TGCCTGACGT CTGGGACCCC GGGTCCCCGG 
GCACAACTGA CTGCGGTGAC CCCAGATACC AGGACCCGGG AGGCCTCAGA GAACTCTGGA 
ACCCGTTCGC GCGCGTGGCT GGCGGTGGCG CTGGGCGCTG GGGGGGCAGT GCTGTTGTTG 
TTGTGGGGCG GGGGTCGGGG TCCTCCGGCC GTCCTCGCCG CCGTCCCTAG CCCGCCGCCC 
GCTTCTCCCC GGAGTCAGTA CAACTTCATC GCAGATGTGG TGGAGAAGAC AGCACCTGCC 
GTGGTCTATA TCGAGATCCT GGACCGGCAC CCTTTCTTGG GCCGCGAGGT CCCTATCTCG 
AACGGCTCAG GATTCGTGGT GGCTGCCGAT GGGCTCATTG TCACCAACGC CCATGTGGTG 
GCTGATCGGC GCAGAGTCCG TGTGAGACTG CTAAGCGGCG ACACGTATGA GGCCGTGGTC 
ACAGCTGTGG ATCCCGTGGC AGACATCGCA ACGCTGAGGA TTCAGACTAA GGAGCCTCTC 
CCCACGCTGC CTCTGGGACG CTCAGCTGAT GTCCGGCAAG GGGAGTTTGT TGTTGCCATG 
GGAAGTCCCT TTGCACTGCA GAACACGATC ACATCCGGCA TTGTTAGCTC TGCTCAGCGT 
CCAGCCAGAG ACCTGGGACT CCCCCAAACC AATGTGGAAT ACATTCAAAC TGATGCAGCT 
ATTGATTTTG GAAACTCTGG AGGTCCCCTG GTTAACCTGG CTAGGGAACT GGGGGCTGTA 
TCCCTGCAGG ATGGGGAGGT GATTGGAGTG AACACCATGA AGGTCACAGC TGGAATCTCC 
TTTGCCATCC CTTCTGATCG TCTTCGAGAG TTTCTGCATC GTGGGGAAAA GAAGAATTCC 
TCCTCCGGAA TCAGTGGGTC CCAGCGGCGC TACATTGGGG TGATGATGCT GACCCTGAGT 
CCCAGGGCTG GTCTGCGGCC TGGTGATGTG ATTTTGGCCA TTGGGGAGCA GATGGTACAA 
AATGCTGAAG ATGTTTATGA AGCTGTTCGA ACCCAATCCC AGTTGGCAGT GCAGATCCGG 
CGGGGACGAG AAACACTGAC CTTATATGTG ACCCCTGAGG TCACAGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA2 ( NM_145074.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_659540.1 Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 2, mRNA.

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CloneID	OHu16180
Clone ID Related Accession (Same CDS sequence)	NM_145074.2
Accession Version	NM_145074.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1086bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	serine protease HTRA2, mitochondrial isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF141305.1, AF184911.1 and BF939362.1. On Aug 24, 2005 this sequence version replaced NM_145074.1. Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1 and has a modified PDZ domain. Isoform 2 has no detectable protease activity. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF184911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2150385, SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGC CGAGGGCGGG GCGGGGTGCA GGCTGGAGCC TTCGGGCATG GCGGGCTTTG 
GGGGGCATTC GCTGGGGGAG GAGACCCCGT TTGACCCCTG ACCTCCGGGC CCTGCTGACG 
TCAGGAACTT CTGACCCCCG GGCCCGAGTG ACTTATGGGA CCCCCAGTCT CTGGGCCCGG 
TTGTCTGTTG GGGTCACTGA ACCCCGAGCA TGCCTGACGT CTGGGACCCC GGGTCCCCGG 
GCACAACTGA CTGCGGTGAC CCCAGATACC AGGACCCGGG AGGCCTCAGA GAACTCTGGA 
ACCCGTTCGC GCGCGTGGCT GGCGGTGGCG CTGGGCGCTG GGGGGGCAGT GCTGTTGTTG 
TTGTGGGGCG GGGGTCGGGG TCCTCCGGCC GTCCTCGCCG CCGTCCCTAG CCCGCCGCCC 
GCTTCTCCCC GGAGTCAGTA CAACTTCATC GCAGATGTGG TGGAGAAGAC AGCACCTGCC 
GTGGTCTATA TCGAGATCCT GGACCGGCAC CCTTTCTTGG GCCGCGAGGT CCCTATCTCG 
AACGGCTCAG GATTCGTGGT GGCTGCCGAT GGGCTCATTG TCACCAACGC CCATGTGGTG 
GCTGATCGGC GCAGAGTCCG TGTGAGACTG CTAAGCGGCG ACACGTATGA GGCCGTGGTC 
ACAGCTGTGG ATCCCGTGGC AGACATCGCA ACGCTGAGGA TTCAGACTAA GTTTGGAAAC 
TCTGGAGGTC CCCTGGTTAA CCTGGATGGG GAGGTGATTG GAGTGAACAC CATGAAGGTC 
ACAGCTGGAA TCTCCTTTGC CATCCCTTCT GATCGTCTTC GAGAGTTTCT GCATCGTGGG 
GAAAAGAAGA ATTCCTCCTC CGGAATCAGT GGGTCCCAGC GGCGCTACAT TGGGGTGATG 
ATGCTGACCC TGAGTCCCAG GGCTGGTCTG CGGCCTGGTG ATGTGATTTT GGCCATTGGG 
GAGCAGATGG TACAAAATGC TGAAGATGTT TATGAAGCTG TTCGAACCCA ATCCCAGTTG 
GCAGTGCAGA TCCGGCGGGG ACGAGAAACA CTGACCTTAT ATGTGACCCC TGAGGTCACA 
GAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659540.1
CDS	603..1688
Translation	MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE

Target ORF information:

RefSeq Version	NM_145074.2
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145074.2

ORF Insert Sequence:

ATGGCTGCGC CGAGGGCGGG GCGGGGTGCA GGCTGGAGCC TTCGGGCATG GCGGGCTTTG 
GGGGGCATTC GCTGGGGGAG GAGACCCCGT TTGACCCCTG ACCTCCGGGC CCTGCTGACG 
TCAGGAACTT CTGACCCCCG GGCCCGAGTG ACTTATGGGA CCCCCAGTCT CTGGGCCCGG 
TTGTCTGTTG GGGTCACTGA ACCCCGAGCA TGCCTGACGT CTGGGACCCC GGGTCCCCGG 
GCACAACTGA CTGCGGTGAC CCCAGATACC AGGACCCGGG AGGCCTCAGA GAACTCTGGA 
ACCCGTTCGC GCGCGTGGCT GGCGGTGGCG CTGGGCGCTG GGGGGGCAGT GCTGTTGTTG 
TTGTGGGGCG GGGGTCGGGG TCCTCCGGCC GTCCTCGCCG CCGTCCCTAG CCCGCCGCCC 
GCTTCTCCCC GGAGTCAGTA CAACTTCATC GCAGATGTGG TGGAGAAGAC AGCACCTGCC 
GTGGTCTATA TCGAGATCCT GGACCGGCAC CCTTTCTTGG GCCGCGAGGT CCCTATCTCG 
AACGGCTCAG GATTCGTGGT GGCTGCCGAT GGGCTCATTG TCACCAACGC CCATGTGGTG 
GCTGATCGGC GCAGAGTCCG TGTGAGACTG CTAAGCGGCG ACACGTATGA GGCCGTGGTC 
ACAGCTGTGG ATCCCGTGGC AGACATCGCA ACGCTGAGGA TTCAGACTAA GTTTGGAAAC 
TCTGGAGGTC CCCTGGTTAA CCTGGATGGG GAGGTGATTG GAGTGAACAC CATGAAGGTC 
ACAGCTGGAA TCTCCTTTGC CATCCCTTCT GATCGTCTTC GAGAGTTTCT GCATCGTGGG 
GAAAAGAAGA ATTCCTCCTC CGGAATCAGT GGGTCCCAGC GGCGCTACAT TGGGGTGATG 
ATGCTGACCC TGAGTCCCAG GGCTGGTCTG CGGCCTGGTG ATGTGATTTT GGCCATTGGG 
GAGCAGATGG TACAAAATGC TGAAGATGTT TATGAAGCTG TTCGAACCCA ATCCCAGTTG 
GCAGTGCAGA TCCGGCGGGG ACGAGAAACA CTGACCTTAT ATGTGACCCC TGAGGTCACA 
GAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HTRA2 ( NM_001321728.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001308657.1 Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 4, mRNA.

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CloneID	OHu35363
Clone ID Related Accession (Same CDS sequence)	NM_001321728.1
Accession Version	NM_001321728.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1281bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	serine protease HTRA2, mitochondrial isoform 4 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005041.2. On Mar 30, 2016 this sequence version replaced XM_005264266.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225932.1, SRR1163658.359708.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCTGCGC CGAGGGCGGG GCGGGGTGCA GGCTGGAGCC TTCGGGCATG GCGGGCTTTG 
GGGGGCATTC GCTGGGGGAG GAGACCCCGT TTGACCCCTG ACCTCCGGGC CCTGCTGACG 
TCAGGAACTT CTGACCCCCG GGCCCGAGTG ACTTATGGGA CCCCCAGTCT CTGGGCCCGG 
TTGTCTGTTG GGGTCACTGA ACCCCGAGCA TGCCTGACGT CTGGGACCCC GGGTCCCCGG 
GCACAACTGA CTGCGGTGAC CCCAGATACC AGGACCCGGG AGGCCTCAGA GAACTCTGGA 
ACCCGTTCGC GCGCGTGGCT GGCGGTGGCG CTGGGCGCTG GGGGGGCAGT GCTGTTGTTG 
TTGTGGGGCG GGGGTCGGGG TCCTCCGGCC GTCCTCGCCG CCGTCCCTAG CCCGCCGCCC 
GCTTCTCCCC GGAGTCAGTA CAACTTCATC GCAGATGTGG TGGAGAAGAC AGCACCTGCC 
GTGGTCTATA TCGAGATCCT GGACCGGCAC CCTTTCTTGG GCCGCGAGGT CCCTATCTCG 
AACGGCTCAG GATTCGTGGT GGCTGCCGAT GGGCTCATTG TCACCAACGC CCATGTGGTG 
GCTGATCGGC GCAGAGTCCG TGTGAGACTG CTAAGCGGCG ACACGTATGA GGCCGTGGTC 
ACAGCTGTGG ATCCCGTGGC AGACATCGCA ACGCTGAGGA TTCAGACTAA GGAGCCTCTC 
CCCACGCTGC CTCTGGGACG CTCAGCTGAT GTCCGGCAAG GGGAGTTTGT TGTTGCCATG 
GGAAGTCCCT TTGCACTGCA GAACACGATC ACATCCGGCA TTGTTAGCTC TGCTCAGCGT 
CCAGCCAGAG ACCTGGGACT CCCCCAAACC AATGTGGAAT ACATTCAAAC TGATGCAGCT 
ATTGATTTTG GAAACTCTGG AGGTCCCCTG GTTAACCTGG ATGGGGAGGT GATTGGAGTG 
AACACCATGA AGGTCACAGC TGGAATCTCC TTTGCCATCC CTTCTGATCG TCTTCGAGAG 
TTTCTGCATC GTGGGGAAAA GAAGAATTCC TCCTCCGGAA TCAGTGGGTC CCAGCGGCGC 
TACATTGGGG TGATGATGCT GACCCTGAGT CCCAGGGCTG GTCTGCGGCC TGGTGATGTG 
ATTTTGGCCA TTGGGGAGCA GATGGTACAA AATGCTGAAG ATGTTTATGA AGCTGTTCGA 
ACCCAATCCC AGTTGGCAGT GCAGATCCGG CGGGGACGAG AAACACTGAC CTTATATGTG 
ACCCCTGAGG TCACAGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001308657.1
CDS	603..1883
Translation	MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE

Target ORF information:

RefSeq Version	NM_001321728.1
Organism	Homo sapiens(human)
Definition	Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001321728.1

ORF Insert Sequence:

ATGGCTGCGC CGAGGGCGGG GCGGGGTGCA GGCTGGAGCC TTCGGGCATG GCGGGCTTTG 
GGGGGCATTC GCTGGGGGAG GAGACCCCGT TTGACCCCTG ACCTCCGGGC CCTGCTGACG 
TCAGGAACTT CTGACCCCCG GGCCCGAGTG ACTTATGGGA CCCCCAGTCT CTGGGCCCGG 
TTGTCTGTTG GGGTCACTGA ACCCCGAGCA TGCCTGACGT CTGGGACCCC GGGTCCCCGG 
GCACAACTGA CTGCGGTGAC CCCAGATACC AGGACCCGGG AGGCCTCAGA GAACTCTGGA 
ACCCGTTCGC GCGCGTGGCT GGCGGTGGCG CTGGGCGCTG GGGGGGCAGT GCTGTTGTTG 
TTGTGGGGCG GGGGTCGGGG TCCTCCGGCC GTCCTCGCCG CCGTCCCTAG CCCGCCGCCC 
GCTTCTCCCC GGAGTCAGTA CAACTTCATC GCAGATGTGG TGGAGAAGAC AGCACCTGCC 
GTGGTCTATA TCGAGATCCT GGACCGGCAC CCTTTCTTGG GCCGCGAGGT CCCTATCTCG 
AACGGCTCAG GATTCGTGGT GGCTGCCGAT GGGCTCATTG TCACCAACGC CCATGTGGTG 
GCTGATCGGC GCAGAGTCCG TGTGAGACTG CTAAGCGGCG ACACGTATGA GGCCGTGGTC 
ACAGCTGTGG ATCCCGTGGC AGACATCGCA ACGCTGAGGA TTCAGACTAA GGAGCCTCTC 
CCCACGCTGC CTCTGGGACG CTCAGCTGAT GTCCGGCAAG GGGAGTTTGT TGTTGCCATG 
GGAAGTCCCT TTGCACTGCA GAACACGATC ACATCCGGCA TTGTTAGCTC TGCTCAGCGT 
CCAGCCAGAG ACCTGGGACT CCCCCAAACC AATGTGGAAT ACATTCAAAC TGATGCAGCT 
ATTGATTTTG GAAACTCTGG AGGTCCCCTG GTTAACCTGG ATGGGGAGGT GATTGGAGTG 
AACACCATGA AGGTCACAGC TGGAATCTCC TTTGCCATCC CTTCTGATCG TCTTCGAGAG 
TTTCTGCATC GTGGGGAAAA GAAGAATTCC TCCTCCGGAA TCAGTGGGTC CCAGCGGCGC 
TACATTGGGG TGATGATGCT GACCCTGAGT CCCAGGGCTG GTCTGCGGCC TGGTGATGTG 
ATTTTGGCCA TTGGGGAGCA GATGGTACAA AATGCTGAAG ATGTTTATGA AGCTGTTCGA 
ACCCAATCCC AGTTGGCAGT GCAGATCCGG CGGGGACGAG AAACACTGAC CTTATATGTG 
ACCCCTGAGG TCACAGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes.
Journal of molecular recognition : JMR(2017 Dec)
Sun ML,Sun LM,Wang YQ

Ovarian serous carcinomas acquire cisplatin resistance and increased invasion through downregulation of the high-temperature-required protein A2 (HtrA2), following repeated treatment with cisplatin.
Medical oncology (Northwood, London, England)34(12)201(2017 Nov)
Soyama H,Miyamoto M,Takano M,Aoyama T,Matsuura H,Sakamoto T,Takasaki K,Kuwahara M,Kato K,Yoshikawa T,Iwahashi H,Tsuda H,Furuya K

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HTRA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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