PCSK1N cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PCSK1N
Entrez Gene ID	27344
Full Name	proprotein convertase subtilisin/kexin type 1 inhibitor
Synonyms	BigLEN,PEN,PROSAAS,SAAS,SCG8,SgVIII
General protein information	Preferred Names proprotein convertase subtilisin/kexin type 1 inhibitor Names proSAAS granin-like neuroendocrine peptide pro-SAAS proprotein convertase 1 inhibitor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.23
Summary	The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013].
Disorder MIM:	300399

mRNA and Protein(s)

mRNA	Protein	Name
NM_013271.4	NP_037403.1	proSAAS preproprotein
NM_013271.5	NP_037403.1	proSAAS preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PCSK1N	XP_003954036.1
Bos taurus (cattle)	PCSK1N	NP_001077149.1
Rattus norvegicus (Norway rat)	Pcsk1n	NP_062152.1
Rattus norvegicus (Norway rat)	LOC100911286	XP_003752060.1
Homo sapiens (human)	PCSK1N	NP_037403.1
Canis lupus familiaris (dog)	PCSK1N	XP_548989.3
	LOC714789	XP_001104714.1
Mus musculus (house mouse)	Pcsk1n	NP_038920.2

Gene Ontology
Bibliography

Related articles in PubMed

The neural chaperone proSAAS blocks ?-synuclein fibrillation and neurotoxicity.
Jarvela TS, Lam HA, Helwig M, Lorenzen N, Otzen DE, McLean PJ, Maidment NT, Lindberg I
Proceedings of the National Academy of Sciences of the United States of America113(32)E4708-15(2016 08)

Frequencies of obesity susceptibility alleles among ethnically and racially diverse bariatric patient populations.
Parikh M, Hetherington J, Sheth S, Seiler J, Ostrer H, Gerhard G, Wood C, Still C
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery9(3)436-41(2013 May-Jun)

Functional consequences of a novel variant of PCSK1.
Pickett LA, Yourshaw M, Albornoz V, Chen Z, Solorzano-Vargas RS, Nelson SF, Mart?n MG, Lindberg I
PloS one8(1)e55065(2013)

Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.
Liu T, Zhao Y, Tang N, Feng R, Yang X, Lu N, Wen J, Li L
PloS one7(10)e46934(2012)

Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers.
Jahn H, Wittke S, Z?rbig P, Raedler TJ, Arlt S, Kellmann M, Mullen W, Eichenlaub M, Mischak H, Wiedemann K
PloS one6(10)e26540(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show significant differences in distribution of single nucleotide polymorphism in this gene amongst whites and hispanics
Title: Frequencies of obesity susceptibility alleles among ethnically and racially diverse bariatric patient populations.

Cloning of proSAAS homologs in Danio and Xenopus identifies conserved, putatively functional areas.
Title: Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences.

ProSAAS or proSAAS-like molecules are trapped within tau fibrils and accumulate in tau inclusions in patients with Alzheimer's disease and parkinsonism-dementia complex.
Title: A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam.

although both proSAAS and 7B2 potently inhibit PC enzymes via a C-terminal peptide, their intracellular interactions with PCs appear to differ significantly, with each binding protein exhibiting unique properties
Title: Functional characterization of ProSAAS: similarities and differences with 7B2.

The following PCSK1N gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PCSK1N cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00831	NM_013271.5 Latest version!	Homo sapiens proprotein convertase subtilisin/kexin type 1 inhibitor (PCSK1N), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu00831	NM_013271.4	Homo sapiens proprotein convertase subtilisin/kexin type 1 inhibitor (PCSK1N), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PCSK1N ( NM_013271.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037403.1 Homo sapiens proprotein convertase subtilisin/kexin type 1 inhibitor (PCSK1N), mRNA.

Price & Availability↑

CloneID	OHu00831
Clone ID Related Accession (Same CDS sequence)	NM_013271.4 , NM_013271.5
Accession Version	NM_013271.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	proSAAS preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC231533.2, BX459856.2, BC002851.2 and HY348068.1. On Aug 22, 2013 this sequence version replaced NM_013271.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX459856.2, BC094731.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGGT CGCCGCTGCT CTGGGGGCCG CGGGCCGGGG GCGTCGGCCT TTTGGTGCTG 
CTGCTGCTCG GCCTGTTTCG GCCGCCCCCC GCGCTCTGCG CGCGGCCGGT AAAGGAGCCC 
CGCGGCCTAA GCGCAGCGTC TCCGCCCTTG GCTGAGACTG GCGCTCCTCG CCGCTTCCGG 
CGGTCAGTGC CCCGAGGTGA GGCGGCGGGG GCGGTGCAGG AGCTGGCGCG GGCGCTGGCG 
CATCTGCTGG AGGCCGAACG TCAGGAGCGG GCGCGGGCCG AGGCGCAGGA GGCTGAGGAT 
CAGCAGGCGC GCGTCCTGGC GCAGCTGCTG CGCGTCTGGG GCGCCCCCCG CAACTCTGAT 
CCGGCTCTGG GCCTGGACGA CGACCCCGAC GCGCCTGCAG CGCAGCTCGC TCGCGCTCTG 
CTCCGCGCCC GCCTTGACCC TGCCGCCCTA GCAGCCCAGC TTGTCCCCGC GCCCGTCCCC 
GCCGCGGCGC TCCGACCCCG GCCCCCGGTC TACGACGACG GCCCCGCGGG CCCGGATGCT 
GAGGAGGCAG GCGACGAGAC ACCCGACGTG GACCCCGAGC TGTTGAGGTA CTTGCTGGGA 
CGGATTCTTG CGGGAAGCGC GGACTCCGAG GGGGTGGCAG CCCCGCGCCG CCTCCGCCGT 
GCCGCCGACC ACGATGTGGG CTCTGAGCTG CCCCCTGAGG GCGTGCTGGG GGCGCTGCTG 
CGTGTGAAAC GCCTAGAGAC CCCGGCGCCC CAGGTGCCTG CACGCCGCCT CTTGCCACCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037403.1
CDS	107..889
Translation	MAGSPLLWGPRAGGVGLLVLLLLGLFRPPPALCARPVKEPRGLSAASPPLAETGAPRRFRRSVPRGEAAGAVQELARALAHLLEAERQERARAEAQEAEDQQARVLAQLLRVWGAPRNSDPALGLDDDPDAPAAQLARALLRARLDPAALAAQLVPAPVPAAALRPRPPVYDDGPAGPDAEEAGDETPDVDPELLRYLLGRILAGSADSEGVAAPRRLRRAADHDVGSELPPEGVLGALLRVKRLETPAPQVPARRLLPP

Target ORF information:

RefSeq Version	NM_013271.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 1 inhibitor (PCSK1N), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013271.4

ORF Insert Sequence:

ATGGCGGGGT CGCCGCTGCT CTGGGGGCCG CGGGCCGGGG GCGTCGGCCT TTTGGTGCTG 
CTGCTGCTCG GCCTGTTTCG GCCGCCCCCC GCGCTCTGCG CGCGGCCGGT AAAGGAGCCC 
CGCGGCCTAA GCGCAGCGTC TCCGCCCTTG GCTGAGACTG GCGCTCCTCG CCGCTTCCGG 
CGGTCAGTGC CCCGAGGTGA GGCGGCGGGG GCGGTGCAGG AGCTGGCGCG GGCGCTGGCG 
CATCTGCTGG AGGCCGAACG TCAGGAGCGG GCGCGGGCCG AGGCGCAGGA GGCTGAGGAT 
CAGCAGGCGC GCGTCCTGGC GCAGCTGCTG CGCGTCTGGG GCGCCCCCCG CAACTCTGAT 
CCGGCTCTGG GCCTGGACGA CGACCCCGAC GCGCCTGCAG CGCAGCTCGC TCGCGCTCTG 
CTCCGCGCCC GCCTTGACCC TGCCGCCCTA GCAGCCCAGC TTGTCCCCGC GCCCGTCCCC 
GCCGCGGCGC TCCGACCCCG GCCCCCGGTC TACGACGACG GCCCCGCGGG CCCGGATGCT 
GAGGAGGCAG GCGACGAGAC ACCCGACGTG GACCCCGAGC TGTTGAGGTA CTTGCTGGGA 
CGGATTCTTG CGGGAAGCGC GGACTCCGAG GGGGTGGCAG CCCCGCGCCG CCTCCGCCGT 
GCCGCCGACC ACGATGTGGG CTCTGAGCTG CCCCCTGAGG GCGTGCTGGG GGCGCTGCTG 
CGTGTGAAAC GCCTAGAGAC CCCGGCGCCC CAGGTGCCTG CACGCCGCCT CTTGCCACCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCSK1N ( NM_013271.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_037403.1 Homo sapiens proprotein convertase subtilisin/kexin type 1 inhibitor (PCSK1N), mRNA.

Price & Availability↑

CloneID	OHu00831
Clone ID Related Accession (Same CDS sequence)	NM_013271.4 , NM_013271.5
Accession Version	NM_013271.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	proSAAS preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX459856.2 and BC002851.2. On Nov 22, 2018 this sequence version replaced NM_013271.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC094731.1, BX459856.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000218230.6/ ENSP00000218230.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGGGT CGCCGCTGCT CTGGGGGCCG CGGGCCGGGG GCGTCGGCCT TTTGGTGCTG 
CTGCTGCTCG GCCTGTTTCG GCCGCCCCCC GCGCTCTGCG CGCGGCCGGT AAAGGAGCCC 
CGCGGCCTAA GCGCAGCGTC TCCGCCCTTG GCTGAGACTG GCGCTCCTCG CCGCTTCCGG 
CGGTCAGTGC CCCGAGGTGA GGCGGCGGGG GCGGTGCAGG AGCTGGCGCG GGCGCTGGCG 
CATCTGCTGG AGGCCGAACG TCAGGAGCGG GCGCGGGCCG AGGCGCAGGA GGCTGAGGAT 
CAGCAGGCGC GCGTCCTGGC GCAGCTGCTG CGCGTCTGGG GCGCCCCCCG CAACTCTGAT 
CCGGCTCTGG GCCTGGACGA CGACCCCGAC GCGCCTGCAG CGCAGCTCGC TCGCGCTCTG 
CTCCGCGCCC GCCTTGACCC TGCCGCCCTA GCAGCCCAGC TTGTCCCCGC GCCCGTCCCC 
GCCGCGGCGC TCCGACCCCG GCCCCCGGTC TACGACGACG GCCCCGCGGG CCCGGATGCT 
GAGGAGGCAG GCGACGAGAC ACCCGACGTG GACCCCGAGC TGTTGAGGTA CTTGCTGGGA 
CGGATTCTTG CGGGAAGCGC GGACTCCGAG GGGGTGGCAG CCCCGCGCCG CCTCCGCCGT 
GCCGCCGACC ACGATGTGGG CTCTGAGCTG CCCCCTGAGG GCGTGCTGGG GGCGCTGCTG 
CGTGTGAAAC GCCTAGAGAC CCCGGCGCCC CAGGTGCCTG CACGCCGCCT CTTGCCACCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037403.1
CDS	79..861
Translation	MAGSPLLWGPRAGGVGLLVLLLLGLFRPPPALCARPVKEPRGLSAASPPLAETGAPRRFRRSVPRGEAAGAVQELARALAHLLEAERQERARAEAQEAEDQQARVLAQLLRVWGAPRNSDPALGLDDDPDAPAAQLARALLRARLDPAALAAQLVPAPVPAAALRPRPPVYDDGPAGPDAEEAGDETPDVDPELLRYLLGRILAGSADSEGVAAPRRLRRAADHDVGSELPPEGVLGALLRVKRLETPAPQVPARRLLPP

Target ORF information:

RefSeq Version	NM_013271.5
Organism	Homo sapiens(human)
Definition	Homo sapiens proprotein convertase subtilisin/kexin type 1 inhibitor (PCSK1N), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013271.5

ORF Insert Sequence:

ATGGCGGGGT CGCCGCTGCT CTGGGGGCCG CGGGCCGGGG GCGTCGGCCT TTTGGTGCTG 
CTGCTGCTCG GCCTGTTTCG GCCGCCCCCC GCGCTCTGCG CGCGGCCGGT AAAGGAGCCC 
CGCGGCCTAA GCGCAGCGTC TCCGCCCTTG GCTGAGACTG GCGCTCCTCG CCGCTTCCGG 
CGGTCAGTGC CCCGAGGTGA GGCGGCGGGG GCGGTGCAGG AGCTGGCGCG GGCGCTGGCG 
CATCTGCTGG AGGCCGAACG TCAGGAGCGG GCGCGGGCCG AGGCGCAGGA GGCTGAGGAT 
CAGCAGGCGC GCGTCCTGGC GCAGCTGCTG CGCGTCTGGG GCGCCCCCCG CAACTCTGAT 
CCGGCTCTGG GCCTGGACGA CGACCCCGAC GCGCCTGCAG CGCAGCTCGC TCGCGCTCTG 
CTCCGCGCCC GCCTTGACCC TGCCGCCCTA GCAGCCCAGC TTGTCCCCGC GCCCGTCCCC 
GCCGCGGCGC TCCGACCCCG GCCCCCGGTC TACGACGACG GCCCCGCGGG CCCGGATGCT 
GAGGAGGCAG GCGACGAGAC ACCCGACGTG GACCCCGAGC TGTTGAGGTA CTTGCTGGGA 
CGGATTCTTG CGGGAAGCGC GGACTCCGAG GGGGTGGCAG CCCCGCGCCG CCTCCGCCGT 
GCCGCCGACC ACGATGTGGG CTCTGAGCTG CCCCCTGAGG GCGTGCTGGG GGCGCTGCTG 
CGTGTGAAAC GCCTAGAGAC CCCGGCGCCC CAGGTGCCTG CACGCCGCCT CTTGCCACCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The neural chaperone proSAAS blocks ?-synuclein fibrillation and neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America113(32)E4708-15(2016 08)
Jarvela TS,Lam HA,Helwig M,Lorenzen N,Otzen DE,McLean PJ,Maidment NT,Lindberg I

Frequencies of obesity susceptibility alleles among ethnically and racially diverse bariatric patient populations.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery9(3)436-41(2013 May-Jun)
Parikh M,Hetherington J,Sheth S,Seiler J,Ostrer H,Gerhard G,Wood C,Still C

Functional consequences of a novel variant of PCSK1.
PloS one8(1)e55065(2013)
Pickett LA,Yourshaw M,Albornoz V,Chen Z,Solorzano-Vargas RS,Nelson SF,Mart?n MG,Lindberg I

Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.
PloS one7(10)e46934(2012)
Liu T,Zhao Y,Tang N,Feng R,Yang X,Lu N,Wen J,Li L

Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers.
PloS one6(10)e26540(2011)
Jahn H,Wittke S,Z?rbig P,Raedler TJ,Arlt S,Kellmann M,Mullen W,Eichenlaub M,Mischak H,Wiedemann K

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PCSK1N cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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