HPGDS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HPGDS
Entrez Gene ID	27306
Full Name	hematopoietic prostaglandin D synthase
Synonyms	GSTS,GSTS1,GSTS1-1,PGD2,PGDS
General protein information	Preferred Names hematopoietic prostaglandin D synthase Names hematopoietic prostaglandin D synthase GST class-sigma glutathione S-transferase sigma glutathione-dependent PGD synthase glutathione-dependent PGD synthetase glutathione-requiring prostaglandin D synthase hematopoietic prostaglandin D2 synthase prostaglandin-H2 D-isomerase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q22.3
Summary	Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008].
Disorder MIM:	602598

mRNA and Protein(s)

mRNA	Protein	Name
XM_005262932.2	XP_005262989.1	hematopoietic prostaglandin D synthase isoform X1
NM_014485.2	NP_055300.1	hematopoietic prostaglandin D synthase
XM_005262932.3	XP_005262989.1	hematopoietic prostaglandin D synthase isoform X1
NM_014485.3	NP_055300.1	hematopoietic prostaglandin D synthase

Pathways from BioSystems

Homologies

	HPGDS	XP_001102342.1
Canis lupus familiaris (dog)	HPGDS	NP_001186973.1
Gallus gallus (chicken)	HPGDS	NP_990342.1
Caenorhabditis elegans (roundworm)	gst-37	NP_503532.1
Caenorhabditis elegans (roundworm)	gst-8	NP_494884.1
Caenorhabditis elegans (roundworm)	gst-3	NP_501846.1
Caenorhabditis elegans (roundworm)	gst-20	NP_496858.1
Caenorhabditis elegans (roundworm)	gst-14	NP_496861.1
Caenorhabditis elegans (roundworm)	gst-16	NP_496863.1
Caenorhabditis elegans (roundworm)	gst-31	NP_497121.1
Caenorhabditis elegans (roundworm)	gst-17	NP_496865.1
Caenorhabditis elegans (roundworm)	gst-27	NP_497116.1
Caenorhabditis elegans (roundworm)	gst-21	NP_001256002.1
Xenopus tropicalis (tropical clawed frog)	hpgds	NP_001005090.1
Drosophila melanogaster (fruit fly)	GstS1	NP_001261040.1
Caenorhabditis elegans (roundworm)	gst-19	NP_496864.1
Caenorhabditis elegans (roundworm)	gst-29	NP_497118.1
Caenorhabditis elegans (roundworm)	gst-35	NP_741061.2
Caenorhabditis elegans (roundworm)	gst-22	NP_507095.1
Caenorhabditis elegans (roundworm)	gst-38	NP_506983.1
Rattus norvegicus (Norway rat)	Hpgds	NP_113832.1
Anopheles gambiae (African malaria mosquito)	GST_ANOGA	XP_311546.4
Caenorhabditis elegans (roundworm)	gst-5	NP_001254267.1
Caenorhabditis elegans (roundworm)	gst-4	NP_501848.1
Caenorhabditis elegans (roundworm)	gst-15	NP_496860.1
Caenorhabditis elegans (roundworm)	gst-39	NP_497119.1
Caenorhabditis elegans (roundworm)	gst-24	NP_496859.1
Pan troglodytes (chimpanzee)	HPGDS	XP_001163736.1
Bos taurus (cattle)	HPGDS	XP_005207797.1
Mus musculus (house mouse)	Hpgds	NP_062328.3
Caenorhabditis elegans (roundworm)	gst-9	NP_001022266.1
Caenorhabditis elegans (roundworm)	gst-6	NP_494882.2
Caenorhabditis elegans (roundworm)	gst-7	NP_494883.1
Caenorhabditis elegans (roundworm)	gst-28	NP_497117.1
Caenorhabditis elegans (roundworm)	gst-13	NP_495967.1
Caenorhabditis elegans (roundworm)	gst-32	NP_497123.2
Caenorhabditis elegans (roundworm)	gst-12	NP_496862.1
Caenorhabditis elegans (roundworm)	gst-34	NP_741060.2
Caenorhabditis elegans (roundworm)	gst-36	NP_509652.2
Homo sapiens (human)	HPGDS	NP_055300.1
Caenorhabditis elegans (roundworm)	gst-30	NP_494902.1
Caenorhabditis elegans (roundworm)	gst-2	NP_501847.1
Caenorhabditis elegans (roundworm)	gst-18	NP_496866.1
Caenorhabditis elegans (roundworm)	gst-26	NP_497115.1
Caenorhabditis elegans (roundworm)	gst-33	NP_503968.1
Caenorhabditis elegans (roundworm)	gst-11	NP_508625.1

Gene Ontology
Bibliography

Related articles in PubMed

Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase.
Meleza C, Thomasson B, Ramachandran C, O'Neill JW, Michelsen K, Lo MC
Analytical biochemistry51117-23(2016 Oct)

Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma.
Hamsten C, H?ggmark A, Grundstr?m J, Mikus M, Lindskog C, Konradsen JR, Eklund A, Pershagen G, Wickman M, Grunewald J, Mel?n E, Hedlin G, Nilsson P, van Hage M
Allergy71(9)1357-61(2016 Sep)

Inhibition of hematopoietic prostaglandin D2 synthase (H-PGDS) by an alkaloid extract from Combretum molle.
Moyo R, Chimponda T, Mukanganyama S
BMC complementary and alternative medicine14221(2014 Jul)

Meta-analysis identifies four new loci associated with testicular germ cell tumor.
Chung CC, Kanetsky PA, Wang Z, Hildebrandt MA, Koster R, Skotheim RI, Kratz CP, Turnbull C, Cortessis VK, Bakken AC, Bishop DT, Cook MB, Erickson RL, Foss? SD, Jacobs KB, Korde LA, Kraggerud SM, Lothe RA, Loud JT, Rahman N, Skinner EC, Thomas DC, Wu X, Yeager M, Schumacher FR, Greene MH, Schwartz SM, McGlynn KA, Chanock SJ, Nathanson KL
Nature genetics45(6)680-5(2013 Jun)

Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin-proteasome system in response to intracellular calcium level.
Yazaki M, Kashiwagi K, Aritake K, Urade Y, Fujimori K
Molecular biology of the cell23(1)12-21(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the development of a competition binding assay amenable to high-throughput screening (HTS) in a scintillation proximity assay (SPA) format. This assay was used to screen an in-house compound library of approximately 280,000 compounds for novel H-PGDS inhibitors.
Title: Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase.

we have utilized a broad-scaled affinity proteomics approach to identify three proteins (CCL5, HPGDS, and NPSR1) with altered plasma levels in asthmatic children compared to healthy controls, representing the first evaluation of HPGDS and NPSR1 in plasma.
Title: Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma.

The effect of C. molle alkaloid extract on H-PGDS was studied. The alkaloid extract exhibited a 70% inhibition on H-PGDS with an IC50 of 13.7 mug/ml.
Title: Inhibition of hematopoietic prostaglandin D2 synthase (H-PGDS) by an alkaloid extract from Combretum molle.

COX-1 and H-PGDS were rapidly ubiquitinated and degraded through the ubiquitin-proteasome system in response to the elevation of the intracellular calcium level
Title: Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin-proteasome system in response to intracellular calcium level.

the Val187Ile HPGDS isoenzyme common among African Americans is not associated with colorectal cancer risk
Title: Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer.

The following HPGDS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HPGDS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20529	NM_014485.3 Latest version!	Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu38878	XM_005262932.3 Latest version!	Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu38878	XM_005262932.2	Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu20529	NM_014485.2	Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HPGDS ( NM_014485.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055300.1 Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), mRNA.

Price & Availability↑

CloneID	OHu20529
Clone ID Related Accession (Same CDS sequence)	NM_014485.2 , NM_014485.3
Accession Version	NM_014485.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-08
Organism	Homo sapiens(human)
Product	hematopoietic prostaglandin D synthase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB988786.1, BC020734.1 and AC096746.3. This sequence is a reference standard in the RefSeqGene project. On Apr 8, 2005 this sequence version replaced NM_014485.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290075.1, SRR1803617.205606.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCAAACT ACAAACTCAC TTATTTTAAT ATGAGGGGGA GAGCAGAAAT TATTCGTTAC 
ATATTTGCTT ATTTGGACAT ACAGTATGAA GACCACAGAA TAGAACAAGC TGACTGGCCT 
GAAATCAAAT CAACTCTCCC ATTTGGAAAA ATCCCCATTT TGGAAGTTGA TGGACTTACT 
CTTCACCAGA GCCTAGCAAT AGCAAGATAT TTGACCAAAA ACACAGATTT GGCTGGAAAC 
ACAGAAATGG AACAATGTCA TGTTGATGCT ATTGTGGACA CTCTGGATGA TTTCATGTCA 
TGTTTTCCTT GGGCAGAGAA AAAGCAAGAT GTGAAAGAGC AGATGTTCAA TGAGCTGCTC 
ACGTATAATG CGCCTCATCT TATGCAAGAC TTGGACACAT ATTTAGGGGG GAGAGAATGG 
CTTATTGGTA ACTCTGTAAC TTGGGCAGAC TTCTACTGGG AGATTTGCAG TACCACACTT 
TTGGTCTTTA AGCCTGACCT GTTAGACAAC CATCCAAGGC TGGTGACTTT ACGGAAGAAA 
GTCCAAGCCA TTCCTGCCGT CGCTAACTGG ATAAAACGAA GGCCCCAAAC CAAACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055300.1
CDS	92..691
Translation	MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL

Target ORF information:

RefSeq Version	NM_014485.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014485.2

ORF Insert Sequence:

ATGCCAAACT ACAAACTCAC TTATTTTAAT ATGAGGGGGA GAGCAGAAAT TATTCGTTAC 
ATATTTGCTT ATTTGGACAT ACAGTATGAA GACCACAGAA TAGAACAAGC TGACTGGCCT 
GAAATCAAAT CAACTCTCCC ATTTGGAAAA ATCCCCATTT TGGAAGTTGA TGGACTTACT 
CTTCACCAGA GCCTAGCAAT AGCAAGATAT TTGACCAAAA ACACAGATTT GGCTGGAAAC 
ACAGAAATGG AACAATGTCA TGTTGATGCT ATTGTGGACA CTCTGGATGA TTTCATGTCA 
TGTTTTCCTT GGGCAGAGAA AAAGCAAGAT GTGAAAGAGC AGATGTTCAA TGAGCTGCTC 
ACGTATAATG CGCCTCATCT TATGCAAGAC TTGGACACAT ATTTAGGGGG GAGAGAATGG 
CTTATTGGTA ACTCTGTAAC TTGGGCAGAC TTCTACTGGG AGATTTGCAG TACCACACTT 
TTGGTCTTTA AGCCTGACCT GTTAGACAAC CATCCAAGGC TGGTGACTTT ACGGAAGAAA 
GTCCAAGCCA TTCCTGCCGT CGCTAACTGG ATAAAACGAA GGCCCCAAAC CAAACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPGDS ( NM_014485.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055300.1 Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), mRNA.

Price & Availability↑

CloneID	OHu20529
Clone ID Related Accession (Same CDS sequence)	NM_014485.2 , NM_014485.3
Accession Version	NM_014485.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	hematopoietic prostaglandin D synthase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020734.1 and AC096746.3. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_014485.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: GQ891393.1, SRR1803617.205606.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000295256.10/ ENSP00000295256.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCAAACT ACAAACTCAC TTATTTTAAT ATGAGGGGGA GAGCAGAAAT TATTCGTTAC 
ATATTTGCTT ATTTGGACAT ACAGTATGAA GACCACAGAA TAGAACAAGC TGACTGGCCT 
GAAATCAAAT CAACTCTCCC ATTTGGAAAA ATCCCCATTT TGGAAGTTGA TGGACTTACT 
CTTCACCAGA GCCTAGCAAT AGCAAGATAT TTGACCAAAA ACACAGATTT GGCTGGAAAC 
ACAGAAATGG AACAATGTCA TGTTGATGCT ATTGTGGACA CTCTGGATGA TTTCATGTCA 
TGTTTTCCTT GGGCAGAGAA AAAGCAAGAT GTGAAAGAGC AGATGTTCAA TGAGCTGCTC 
ACGTATAATG CGCCTCATCT TATGCAAGAC TTGGACACAT ATTTAGGGGG GAGAGAATGG 
CTTATTGGTA ACTCTGTAAC TTGGGCAGAC TTCTACTGGG AGATTTGCAG TACCACACTT 
TTGGTCTTTA AGCCTGACCT GTTAGACAAC CATCCAAGGC TGGTGACTTT ACGGAAGAAA 
GTCCAAGCCA TTCCTGCCGT CGCTAACTGG ATAAAACGAA GGCCCCAAAC CAAACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055300.1
CDS	52..651
Translation	MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL

Target ORF information:

RefSeq Version	NM_014485.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014485.3

ORF Insert Sequence:

ATGCCAAACT ACAAACTCAC TTATTTTAAT ATGAGGGGGA GAGCAGAAAT TATTCGTTAC 
ATATTTGCTT ATTTGGACAT ACAGTATGAA GACCACAGAA TAGAACAAGC TGACTGGCCT 
GAAATCAAAT CAACTCTCCC ATTTGGAAAA ATCCCCATTT TGGAAGTTGA TGGACTTACT 
CTTCACCAGA GCCTAGCAAT AGCAAGATAT TTGACCAAAA ACACAGATTT GGCTGGAAAC 
ACAGAAATGG AACAATGTCA TGTTGATGCT ATTGTGGACA CTCTGGATGA TTTCATGTCA 
TGTTTTCCTT GGGCAGAGAA AAAGCAAGAT GTGAAAGAGC AGATGTTCAA TGAGCTGCTC 
ACGTATAATG CGCCTCATCT TATGCAAGAC TTGGACACAT ATTTAGGGGG GAGAGAATGG 
CTTATTGGTA ACTCTGTAAC TTGGGCAGAC TTCTACTGGG AGATTTGCAG TACCACACTT 
TTGGTCTTTA AGCCTGACCT GTTAGACAAC CATCCAAGGC TGGTGACTTT ACGGAAGAAA 
GTCCAAGCCA TTCCTGCCGT CGCTAACTGG ATAAAACGAA GGCCCCAAAC CAAACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPGDS ( XM_005262932.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005262989.1 Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu38878
Clone ID Related Accession (Same CDS sequence)	XM_005262932.2 , XM_005262932.3
Accession Version	XM_005262932.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	hematopoietic prostaglandin D synthase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005262932.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAAACT ACAAACTCAC TTATTTTAAT ATGAGGGGGA GAGCAGAAAT TATTCGTTAC 
ATATTTGCTT ATTTGGACAT ACAGTATGAA GACCACAGAA TAGAACAAGC TGACTGGCCT 
GAAATCAAAT CAAATTTGGC TGGAAACACA GAAATGGAAC AATGTCATGT TGATGCTATT 
GTGGACACTC TGGATGATTT CATGTCATGT TTTCCTTGGG CAGAGAAAAA GCAAGATGTG 
AAAGAGCAGA TGTTCAATGA GCTGCTCACG TATAATGCGC CTCATCTTAT GCAAGACTTG 
GACACATATT TAGGGGGGAG AGAATGGCTT ATTGGTAACT CTGTAACTTG GGCAGACTTC 
TACTGGGAGA TTTGCAGTAC CACACTTTTG GTCTTTAAGC CTGACCTGTT AGACAACCAT 
CCAAGGCTGG TGACTTTACG GAAGAAAGTC CAAGCCATTC CTGCCGTCGC TAACTGGATA 
AAACGAAGGC CCCAAACCAA ACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005262989.1
CDS	92..598
Translation	MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSNLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL

Target ORF information:

RefSeq Version	XM_005262932.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005262932.2

ORF Insert Sequence:

ATGCCAAACT ACAAACTCAC TTATTTTAAT ATGAGGGGGA GAGCAGAAAT TATTCGTTAC 
ATATTTGCTT ATTTGGACAT ACAGTATGAA GACCACAGAA TAGAACAAGC TGACTGGCCT 
GAAATCAAAT CAAATTTGGC TGGAAACACA GAAATGGAAC AATGTCATGT TGATGCTATT 
GTGGACACTC TGGATGATTT CATGTCATGT TTTCCTTGGG CAGAGAAAAA GCAAGATGTG 
AAAGAGCAGA TGTTCAATGA GCTGCTCACG TATAATGCGC CTCATCTTAT GCAAGACTTG 
GACACATATT TAGGGGGGAG AGAATGGCTT ATTGGTAACT CTGTAACTTG GGCAGACTTC 
TACTGGGAGA TTTGCAGTAC CACACTTTTG GTCTTTAAGC CTGACCTGTT AGACAACCAT 
CCAAGGCTGG TGACTTTACG GAAGAAAGTC CAAGCCATTC CTGCCGTCGC TAACTGGATA 
AAACGAAGGC CCCAAACCAA ACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPGDS ( XM_005262932.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005262989.1 Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu38878
Clone ID Related Accession (Same CDS sequence)	XM_005262932.2 , XM_005262932.3
Accession Version	XM_005262932.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	hematopoietic prostaglandin D synthase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005262932.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAAACT ACAAACTCAC TTATTTTAAT ATGAGGGGGA GAGCAGAAAT TATTCGTTAC 
ATATTTGCTT ATTTGGACAT ACAGTATGAA GACCACAGAA TAGAACAAGC TGACTGGCCT 
GAAATCAAAT CAAATTTGGC TGGAAACACA GAAATGGAAC AATGTCATGT TGATGCTATT 
GTGGACACTC TGGATGATTT CATGTCATGT TTTCCTTGGG CAGAGAAAAA GCAAGATGTG 
AAAGAGCAGA TGTTCAATGA GCTGCTCACG TATAATGCGC CTCATCTTAT GCAAGACTTG 
GACACATATT TAGGGGGGAG AGAATGGCTT ATTGGTAACT CTGTAACTTG GGCAGACTTC 
TACTGGGAGA TTTGCAGTAC CACACTTTTG GTCTTTAAGC CTGACCTGTT AGACAACCAT 
CCAAGGCTGG TGACTTTACG GAAGAAAGTC CAAGCCATTC CTGCCGTCGC TAACTGGATA 
AAACGAAGGC CCCAAACCAA ACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005262989.1
CDS	92..598
Translation	MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSNLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL

Target ORF information:

RefSeq Version	XM_005262932.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hematopoietic prostaglandin D synthase (HPGDS), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005262932.3

ORF Insert Sequence:

ATGCCAAACT ACAAACTCAC TTATTTTAAT ATGAGGGGGA GAGCAGAAAT TATTCGTTAC 
ATATTTGCTT ATTTGGACAT ACAGTATGAA GACCACAGAA TAGAACAAGC TGACTGGCCT 
GAAATCAAAT CAAATTTGGC TGGAAACACA GAAATGGAAC AATGTCATGT TGATGCTATT 
GTGGACACTC TGGATGATTT CATGTCATGT TTTCCTTGGG CAGAGAAAAA GCAAGATGTG 
AAAGAGCAGA TGTTCAATGA GCTGCTCACG TATAATGCGC CTCATCTTAT GCAAGACTTG 
GACACATATT TAGGGGGGAG AGAATGGCTT ATTGGTAACT CTGTAACTTG GGCAGACTTC 
TACTGGGAGA TTTGCAGTAC CACACTTTTG GTCTTTAAGC CTGACCTGTT AGACAACCAT 
CCAAGGCTGG TGACTTTACG GAAGAAAGTC CAAGCCATTC CTGCCGTCGC TAACTGGATA 
AAACGAAGGC CCCAAACCAA ACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase.
Analytical biochemistry51117-23(2016 Oct)
Meleza C,Thomasson B,Ramachandran C,O'Neill JW,Michelsen K,Lo MC

Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma.
Allergy71(9)1357-61(2016 Sep)
Hamsten C,H?ggmark A,Grundstr?m J,Mikus M,Lindskog C,Konradsen JR,Eklund A,Pershagen G,Wickman M,Grunewald J,Mel?n E,Hedlin G,Nilsson P,van Hage M

Inhibition of hematopoietic prostaglandin D2 synthase (H-PGDS) by an alkaloid extract from Combretum molle.
BMC complementary and alternative medicine14221(2014 Jul)
Moyo R,Chimponda T,Mukanganyama S

Meta-analysis identifies four new loci associated with testicular germ cell tumor.
Nature genetics45(6)680-5(2013 Jun)
Chung CC,Kanetsky PA,Wang Z,Hildebrandt MA,Koster R,Skotheim RI,Kratz CP,Turnbull C,Cortessis VK,Bakken AC,Bishop DT,Cook MB,Erickson RL,Foss? SD,Jacobs KB,Korde LA,Kraggerud SM,Lothe RA,Loud JT,Rahman N,Skinner EC,Thomas DC,Wu X,Yeager M,Schumacher FR,Greene MH,Schwartz SM,McGlynn KA,Chanock SJ,Nathanson KL

Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin-proteasome system in response to intracellular calcium level.
Molecular biology of the cell23(1)12-21(2012 Jan)
Yazaki M,Kashiwagi K,Aritake K,Urade Y,Fujimori K

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HPGDS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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