MOCS3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MOCS3
Entrez Gene ID	27304
Full Name	molybdenum cofactor synthesis 3
Synonyms	UBA4
General protein information	Preferred Names molybdenum cofactor synthesis 3 Names adenylyltransferase and sulfurtransferase MOCS3 MPT synthase sulfurylase UBA4, ubiquitin-activating enzyme E1 homolog molybdenum cofactor synthesis protein 3 molybdopterin synthase sulfurylase ubiquitin-like modifier activating enzyme 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.13
Summary	Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012].
Disorder MIM:	609277

mRNA and Protein(s)

mRNA	Protein	Name
NM_014484.4	NP_055299.1	adenylyltransferase and sulfurtransferase MOCS3
NM_014484.5	NP_055299.1	adenylyltransferase and sulfurtransferase MOCS3

Pathways from BioSystems

Homologies

Saccharomyces cerevisiae (baker's yeast)	UBA4	NP_011979.1
Kluyveromyces lactis	KLLA0E21363g	XP_454917.1
Xenopus tropicalis (tropical clawed frog)	LOC100491723	XP_002935865.2
Mus musculus (house mouse)	Mocs3	NP_001153802.1
Danio rerio (zebrafish)	mocs3	NP_956421.1
Drosophila melanogaster (fruit fly)	CG13090	NP_001260255.1
Caenorhabditis elegans (roundworm)	moc-3	NP_501359.1
Magnaporthe oryzae (rice blast fungus)	MGG_05569	XP_003710444.1
Neurospora crassa	NCU00736	XP_964389.1
Arabidopsis thaliana (thale cress)	CNX5	NP_200324.1
Oryza sativa (rice)	Os02g0525400	NP_001046992.1
Homo sapiens (human)	MOCS3	NP_055299.1
Gallus gallus (chicken)	MOCS3	XP_001232656.1
Pan troglodytes (chimpanzee)	MOCS3	XP_514724.2
Rattus norvegicus (Norway rat)	Mocs3	NP_001101274.1
Eremothecium gossypii	AGOS_AER248W	NP_985105.1
Schizosaccharomyces pombe (fission yeast)	SPAC2G11.10c	NP_593090.1
	MOCS3	XP_001093903.1
Canis lupus familiaris (dog)	MOCS3	XP_543052.2
Anopheles gambiae (African malaria mosquito)	MOCS3_ANOGA	XP_321349.4

Gene Ontology
Bibliography

Related articles in PubMed

Molybdenum cofactor deficiency: Identification of a patient with homozygote mutation in the MOCS3 gene.
Huijmans JGM, Schot R, de Klerk JBC, Williams M, de Coo RFM, Duran M, Verheijen FW, van Slegtenhorst M, Mancini GMS
American journal of medical genetics. Part A173(6)1601-1606(2017 Jun)

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.
Jackson VE, Ntalla I, Sayers I, Morris R, Whincup P, Casas JP, Amuzu A, Choi M, Dale C, Kumari M, Engmann J, Kalsheker N, Chappell S, Guetta-Baranes T, McKeever TM, Palmer CN, Tavendale R, Holloway JW, Sayer AA, Dennison EM, Cooper C, Bafadhel M, Barker B, Brightling C, Bolton CE, John ME, Parker SG, Moffat MF, Wardlaw AJ, Connolly MJ, Porteous DJ, Smith BH, Padmanabhan S, Hocking L, Stirrups KE, Deloukas P, Strachan DP, Hall IP, Tobin MD, Wain LV
Thorax71(6)501-9(2016 06)

Urmylation and tRNA thiolation functions of ubiquitin-like Uba4?Urm1 systems are conserved from yeast to man.
J?des A, Ebert F, B?r C, Th?ring KL, Harrer A, Klassen R, Helm M, Stark MJ, Schaffrath R
FEBS letters589(8)904-9(2015 Apr)

Dual role of the molybdenum cofactor biosynthesis protein MOCS3 in tRNA thiolation and molybdenum cofactor biosynthesis in humans.
Chowdhury MM, Dosche C, L?hmannsr?ben HG, Leimk?hler S
The Journal of biological chemistry287(21)17297-307(2012 May)

Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.
Van der Veen AG, Schorpp K, Schlieker C, Buti L, Damon JR, Spooner E, Ploegh HL, Jentsch S
Proceedings of the National Academy of Sciences of the United States of America108(5)1763-70(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This observation should encourage testing of additional intellectual disability patients with mild abnormalities of sulfite metabolism for MOCS3 mutations.
Title: Molybdenum cofactor deficiency: Identification of a patient with homozygote mutation in the MOCS3 gene.

Among the associated variants were two in regions previously unreported for COPD; a low frequency non-synonymous SNP in MOCS3 (rs7269297, pdiscovery=3.08x10(-6), preplication=0.019) and a rare SNP in IFIT3, which emerged in the meta-analysis (rs140549288, pmeta=8.56x10(-6)).
Title: Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

ubiquitin-like Urm1.Uba4 systems are conserved and exchangeable between human and yeast cells
Title: Urmylation and tRNA thiolation functions of ubiquitin-like Uba4?Urm1 systems are conserved from yeast to man.

extension of the C terminus with an additional glycine of MOCS2A and URM1 altered the localization of MOCS3 from the cytosol to the nucleus.
Title: Dual role of the molybdenum cofactor biosynthesis protein MOCS3 in tRNA thiolation and molybdenum cofactor biosynthesis in humans.

Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis
Title: A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis.

The following MOCS3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MOCS3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00422	NM_014484.5 Latest version!	Homo sapiens molybdenum cofactor synthesis 3 (MOCS3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu00422	NM_014484.4	Homo sapiens molybdenum cofactor synthesis 3 (MOCS3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MOCS3 ( NM_014484.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055299.1 Homo sapiens molybdenum cofactor synthesis 3 (MOCS3), mRNA.

Price & Availability↑

CloneID	OHu00422
Clone ID Related Accession (Same CDS sequence)	NM_014484.4 , NM_014484.5
Accession Version	NM_014484.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	adenylyltransferase and sulfurtransferase MOCS3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB452633.1, AF102544.1, BC015939.2, HY215239.1, BY995583.1, BQ188547.1 and AI942426.1. On Nov 14, 2012 this sequence version replaced NM_014484.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGCTTCCC GGGAGGAGGT ACTCGCCTTA CAAGCTGAAG TTGCCCAACG TGAGGAGGAA 
TTGAATTCGC TGAAGCAGAA GCTGGCGTCG GCTCTTTTGG CTGAGCAGGA ACCGCAGCCA 
GAACGGCTGG TTCCGGTGTC GCCGCTGCCG CCGAAGGCCG CTCTGTCCCG AGATGAGATT 
CTGCGCTATA GCCGGCAGCT AGTGCTGCCC GAGCTGGGCG TGCACGGACA GCTGCGCCTG 
GGGACCGCGT GCGTGCTAAT CGTGGGCTGC GGTGGGCTCG GCTGTCCACT AGCGCAGTAC 
TTGGCAGCGG CCGGCGTGGG CCGCCTTGGC CTTGTGGACT ATGACGTGGT AGAGATGAGC 
AACCTGGCCC GCCAAGTGCT GCATGGCGAG GCACTGGCTG GCCAGGCCAA GGCCTTTTCG 
GCCGCCGCCT CGCTGCGCCG CCTCAATTCG GCAGTGGAAT GCGTGCCGTA CACTCAGGCC 
CTTACGCCAG CCACTGCCCT AGACCTGGTC CGCCGATATG ATGTGGTGGC TGACTGCTCG 
GACAACGTGC CCACTCGCTA CCTGGTTAAT GACGCATGTG TGCTGGCGGG TCGGCCCCTC 
GTGTCTGCCA GTGCCTTGCG CTTCGAGGGC CAAATCACAG TCTACCATTA TGACGGTGGC 
CCTTGCTATC GCTGCATATT CCCCCAACCA CCCCCAGCGG AGACAGTGAC CAACTGCGCG 
GACGGCGGGG TGCTCGGTGT CGTTACCGGG GTCCTGGGCT GCCTGCAGGC CTTGGAAGTG 
CTGAAAATCG CTGCGGGTCT GGGCCCCTCT TACAGTGGCA GCTTGTTGCT CTTTGATGCC 
CTGAGAGGGC ATTTCCGCTC TATTCGGCTG CGGAGCCGCA GGCTCGACTG TGCAGCTTGC 
GGGGAACGGC CCACTGTGAC TGATCTGCTG GACTATGAAG CCTTCTGTGG CTCCTCAGCC 
ACTGATAAAT GCCGCTCCCT GCAACTACTG AGCCCAGAGG AGCGTGTTTC TGTCACCGAC 
TATAAGCGAC TGCTGGATTC TGGGGCATTC CACCTGTTGC TGGACGTCAG GCCTCAGGTG 
GAGGTGGACA TTTGTCGTTT GCCTCATGCC CTACACATCC CTCTGAAACA TTTGGAACGC 
AGGGATGCGG AGAGCCTGAA ACTCTTAAAA GAAGCAATCT GGGAAGAGAA GCAGGGCACA 
CAAGAAGGGG CTGCTGTCCC CATTTATGTG ATTTGCAAAC TGGGAAATGA CTCACAGAAA 
GCCGTGAAGA TCCTCCAGTC CTTATCAGCA GCTCAAGAGT TAGACCCTTT AACAGTTCGG 
GATGTTGTGG GGGGCCTCAT GGCCTGGGCT GCCAAAATCG ATGGAACATT TCCACAGTAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055299.1
CDS	30..1412
Translation	MASREEVLALQAEVAQREEELNSLKQKLASALLAEQEPQPERLVPVSPLPPKAALSRDEILRYSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGLVDYDVVEMSNLARQVLHGEALAGQAKAFSAAASLRRLNSAVECVPYTQALTPATALDLVRRYDVVADCSDNVPTRYLVNDACVLAGRPLVSASALRFEGQITVYHYDGGPCYRCIFPQPPPAETVTNCADGGVLGVVTGVLGCLQALEVLKIAAGLGPSYSGSLLLFDALRGHFRSIRLRSRRLDCAACGERPTVTDLLDYEAFCGSSATDKCRSLQLLSPEERVSVTDYKRLLDSGAFHLLLDVRPQVEVDICRLPHALHIPLKHLERRDAESLKLLKEAIWEEKQGTQEGAAVPIYVICKLGNDSQKAVKILQSLSAAQELDPLTVRDVVGGLMAWAAKIDGTFPQY

Target ORF information:

RefSeq Version	NM_014484.4
Organism	Homo sapiens(human)
Definition	Homo sapiens molybdenum cofactor synthesis 3 (MOCS3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014484.4

ORF Insert Sequence:

ATGGCTTCCC GGGAGGAGGT ACTCGCCTTA CAAGCTGAAG TTGCCCAACG TGAGGAGGAA 
TTGAATTCGC TGAAGCAGAA GCTGGCGTCG GCTCTTTTGG CTGAGCAGGA ACCGCAGCCA 
GAACGGCTGG TTCCGGTGTC GCCGCTGCCG CCGAAGGCCG CTCTGTCCCG AGATGAGATT 
CTGCGCTATA GCCGGCAGCT AGTGCTGCCC GAGCTGGGCG TGCACGGACA GCTGCGCCTG 
GGGACCGCGT GCGTGCTAAT CGTGGGCTGC GGTGGGCTCG GCTGTCCACT AGCGCAGTAC 
TTGGCAGCGG CCGGCGTGGG CCGCCTTGGC CTTGTGGACT ATGACGTGGT AGAGATGAGC 
AACCTGGCCC GCCAAGTGCT GCATGGCGAG GCACTGGCTG GCCAGGCCAA GGCCTTTTCG 
GCCGCCGCCT CGCTGCGCCG CCTCAATTCG GCAGTGGAAT GCGTGCCGTA CACTCAGGCC 
CTTACGCCAG CCACTGCCCT AGACCTGGTC CGCCGATATG ATGTGGTGGC TGACTGCTCG 
GACAACGTGC CCACTCGCTA CCTGGTTAAT GACGCATGTG TGCTGGCGGG TCGGCCCCTC 
GTGTCTGCCA GTGCCTTGCG CTTCGAGGGC CAAATCACAG TCTACCATTA TGACGGTGGC 
CCTTGCTATC GCTGCATATT CCCCCAACCA CCCCCAGCGG AGACAGTGAC CAACTGCGCG 
GACGGCGGGG TGCTCGGTGT CGTTACCGGG GTCCTGGGCT GCCTGCAGGC CTTGGAAGTG 
CTGAAAATCG CTGCGGGTCT GGGCCCCTCT TACAGTGGCA GCTTGTTGCT CTTTGATGCC 
CTGAGAGGGC ATTTCCGCTC TATTCGGCTG CGGAGCCGCA GGCTCGACTG TGCAGCTTGC 
GGGGAACGGC CCACTGTGAC TGATCTGCTG GACTATGAAG CCTTCTGTGG CTCCTCAGCC 
ACTGATAAAT GCCGCTCCCT GCAACTACTG AGCCCAGAGG AGCGTGTTTC TGTCACCGAC 
TATAAGCGAC TGCTGGATTC TGGGGCATTC CACCTGTTGC TGGACGTCAG GCCTCAGGTG 
GAGGTGGACA TTTGTCGTTT GCCTCATGCC CTACACATCC CTCTGAAACA TTTGGAACGC 
AGGGATGCGG AGAGCCTGAA ACTCTTAAAA GAAGCAATCT GGGAAGAGAA GCAGGGCACA 
CAAGAAGGGG CTGCTGTCCC CATTTATGTG ATTTGCAAAC TGGGAAATGA CTCACAGAAA 
GCCGTGAAGA TCCTCCAGTC CTTATCAGCA GCTCAAGAGT TAGACCCTTT AACAGTTCGG 
GATGTTGTGG GGGGCCTCAT GGCCTGGGCT GCCAAAATCG ATGGAACATT TCCACAGTAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MOCS3 ( NM_014484.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055299.1 Homo sapiens molybdenum cofactor synthesis 3 (MOCS3), mRNA.

Price & Availability↑

CloneID	OHu00422
Clone ID Related Accession (Same CDS sequence)	NM_014484.4 , NM_014484.5
Accession Version	NM_014484.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	adenylyltransferase and sulfurtransferase MOCS3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB452633.1, AF102544.1, BC015939.2, HY215239.1, BY995583.1, BQ188547.1, AI942426.1 and AL034553.12. On May 17, 2019 this sequence version replaced NM_014484.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR1803617.267477.1, SRR1803613.28578.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244051.3/ ENSP00000244051.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCCC GGGAGGAGGT ACTCGCCTTA CAAGCTGAAG TTGCCCAACG TGAGGAGGAA 
TTGAATTCGC TGAAGCAGAA GCTGGCGTCG GCTCTTTTGG CTGAGCAGGA ACCGCAGCCA 
GAACGGCTGG TTCCGGTGTC GCCGCTGCCG CCGAAGGCCG CTCTGTCCCG AGATGAGATT 
CTGCGCTATA GCCGGCAGCT AGTGCTGCCC GAGCTGGGCG TGCACGGACA GCTGCGCCTG 
GGGACCGCGT GCGTGCTAAT CGTGGGCTGC GGTGGGCTCG GCTGTCCACT AGCGCAGTAC 
TTGGCAGCGG CCGGCGTGGG CCGCCTTGGC CTTGTGGACT ATGACGTGGT AGAGATGAGC 
AACCTGGCCC GCCAAGTGCT GCATGGCGAG GCACTGGCTG GCCAGGCCAA GGCCTTTTCG 
GCCGCCGCCT CGCTGCGCCG CCTCAATTCG GCAGTGGAAT GCGTGCCGTA CACTCAGGCC 
CTTACGCCAG CCACTGCCCT AGACCTGGTC CGCCGATATG ATGTGGTGGC TGACTGCTCG 
GACAACGTGC CCACTCGCTA CCTGGTTAAT GACGCATGTG TGCTGGCGGG TCGGCCCCTC 
GTGTCTGCCA GTGCCTTGCG CTTCGAGGGC CAAATCACAG TCTACCATTA TGACGGTGGC 
CCTTGCTATC GCTGCATATT CCCCCAACCA CCCCCAGCGG AGACAGTGAC CAACTGCGCG 
GACGGCGGGG TGCTCGGTGT CGTTACCGGG GTCCTGGGCT GCCTGCAGGC CTTGGAAGTG 
CTGAAAATCG CTGCGGGTCT GGGCCCCTCT TACAGTGGCA GCTTGTTGCT CTTTGATGCC 
CTGAGAGGGC ATTTCCGCTC TATTCGGCTG CGGAGCCGCA GGCTCGACTG TGCAGCTTGC 
GGGGAACGGC CCACTGTGAC TGATCTGCTG GACTATGAAG CCTTCTGTGG CTCCTCAGCC 
ACTGATAAAT GCCGCTCCCT GCAACTACTG AGCCCAGAGG AGCGTGTTTC TGTCACCGAC 
TATAAGCGAC TGCTGGATTC TGGGGCATTC CACCTGTTGC TGGACGTCAG GCCTCAGGTG 
GAGGTGGACA TTTGTCGTTT GCCTCATGCC CTACACATCC CTCTGAAACA TTTGGAACGC 
AGGGATGCGG AGAGCCTGAA ACTCTTAAAA GAAGCAATCT GGGAAGAGAA GCAGGGCACA 
CAAGAAGGGG CTGCTGTCCC CATTTATGTG ATTTGCAAAC TGGGAAATGA CTCACAGAAA 
GCCGTGAAGA TCCTCCAGTC CTTATCAGCA GCTCAAGAGT TAGACCCTTT AACAGTTCGG 
GATGTTGTGG GGGGCCTCAT GGCCTGGGCT GCCAAAATCG ATGGAACATT TCCACAGTAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055299.1
CDS	26..1408
Translation	MASREEVLALQAEVAQREEELNSLKQKLASALLAEQEPQPERLVPVSPLPPKAALSRDEILRYSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGLVDYDVVEMSNLARQVLHGEALAGQAKAFSAAASLRRLNSAVECVPYTQALTPATALDLVRRYDVVADCSDNVPTRYLVNDACVLAGRPLVSASALRFEGQITVYHYDGGPCYRCIFPQPPPAETVTNCADGGVLGVVTGVLGCLQALEVLKIAAGLGPSYSGSLLLFDALRGHFRSIRLRSRRLDCAACGERPTVTDLLDYEAFCGSSATDKCRSLQLLSPEERVSVTDYKRLLDSGAFHLLLDVRPQVEVDICRLPHALHIPLKHLERRDAESLKLLKEAIWEEKQGTQEGAAVPIYVICKLGNDSQKAVKILQSLSAAQELDPLTVRDVVGGLMAWAAKIDGTFPQY

Target ORF information:

RefSeq Version	NM_014484.5
Organism	Homo sapiens(human)
Definition	Homo sapiens molybdenum cofactor synthesis 3 (MOCS3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014484.5

ORF Insert Sequence:

ATGGCTTCCC GGGAGGAGGT ACTCGCCTTA CAAGCTGAAG TTGCCCAACG TGAGGAGGAA 
TTGAATTCGC TGAAGCAGAA GCTGGCGTCG GCTCTTTTGG CTGAGCAGGA ACCGCAGCCA 
GAACGGCTGG TTCCGGTGTC GCCGCTGCCG CCGAAGGCCG CTCTGTCCCG AGATGAGATT 
CTGCGCTATA GCCGGCAGCT AGTGCTGCCC GAGCTGGGCG TGCACGGACA GCTGCGCCTG 
GGGACCGCGT GCGTGCTAAT CGTGGGCTGC GGTGGGCTCG GCTGTCCACT AGCGCAGTAC 
TTGGCAGCGG CCGGCGTGGG CCGCCTTGGC CTTGTGGACT ATGACGTGGT AGAGATGAGC 
AACCTGGCCC GCCAAGTGCT GCATGGCGAG GCACTGGCTG GCCAGGCCAA GGCCTTTTCG 
GCCGCCGCCT CGCTGCGCCG CCTCAATTCG GCAGTGGAAT GCGTGCCGTA CACTCAGGCC 
CTTACGCCAG CCACTGCCCT AGACCTGGTC CGCCGATATG ATGTGGTGGC TGACTGCTCG 
GACAACGTGC CCACTCGCTA CCTGGTTAAT GACGCATGTG TGCTGGCGGG TCGGCCCCTC 
GTGTCTGCCA GTGCCTTGCG CTTCGAGGGC CAAATCACAG TCTACCATTA TGACGGTGGC 
CCTTGCTATC GCTGCATATT CCCCCAACCA CCCCCAGCGG AGACAGTGAC CAACTGCGCG 
GACGGCGGGG TGCTCGGTGT CGTTACCGGG GTCCTGGGCT GCCTGCAGGC CTTGGAAGTG 
CTGAAAATCG CTGCGGGTCT GGGCCCCTCT TACAGTGGCA GCTTGTTGCT CTTTGATGCC 
CTGAGAGGGC ATTTCCGCTC TATTCGGCTG CGGAGCCGCA GGCTCGACTG TGCAGCTTGC 
GGGGAACGGC CCACTGTGAC TGATCTGCTG GACTATGAAG CCTTCTGTGG CTCCTCAGCC 
ACTGATAAAT GCCGCTCCCT GCAACTACTG AGCCCAGAGG AGCGTGTTTC TGTCACCGAC 
TATAAGCGAC TGCTGGATTC TGGGGCATTC CACCTGTTGC TGGACGTCAG GCCTCAGGTG 
GAGGTGGACA TTTGTCGTTT GCCTCATGCC CTACACATCC CTCTGAAACA TTTGGAACGC 
AGGGATGCGG AGAGCCTGAA ACTCTTAAAA GAAGCAATCT GGGAAGAGAA GCAGGGCACA 
CAAGAAGGGG CTGCTGTCCC CATTTATGTG ATTTGCAAAC TGGGAAATGA CTCACAGAAA 
GCCGTGAAGA TCCTCCAGTC CTTATCAGCA GCTCAAGAGT TAGACCCTTT AACAGTTCGG 
GATGTTGTGG GGGGCCTCAT GGCCTGGGCT GCCAAAATCG ATGGAACATT TCCACAGTAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molybdenum cofactor deficiency: Identification of a patient with homozygote mutation in the MOCS3 gene.
American journal of medical genetics. Part A173(6)1601-1606(2017 Jun)
Huijmans JGM,Schot R,de Klerk JBC,Williams M,de Coo RFM,Duran M,Verheijen FW,van Slegtenhorst M,Mancini GMS

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.
Thorax71(6)501-9(2016 06)
Jackson VE,Ntalla I,Sayers I,Morris R,Whincup P,Casas JP,Amuzu A,Choi M,Dale C,Kumari M,Engmann J,Kalsheker N,Chappell S,Guetta-Baranes T,McKeever TM,Palmer CN,Tavendale R,Holloway JW,Sayer AA,Dennison EM,Cooper C,Bafadhel M,Barker B,Brightling C,Bolton CE,John ME,Parker SG,Moffat MF,Wardlaw AJ,Connolly MJ,Porteous DJ,Smith BH,Padmanabhan S,Hocking L,Stirrups KE,Deloukas P,Strachan DP,Hall IP,Tobin MD,Wain LV

Urmylation and tRNA thiolation functions of ubiquitin-like Uba4?Urm1 systems are conserved from yeast to man.
FEBS letters589(8)904-9(2015 Apr)
J?des A,Ebert F,B?r C,Th?ring KL,Harrer A,Klassen R,Helm M,Stark MJ,Schaffrath R

Dual role of the molybdenum cofactor biosynthesis protein MOCS3 in tRNA thiolation and molybdenum cofactor biosynthesis in humans.
The Journal of biological chemistry287(21)17297-307(2012 May)
Chowdhury MM,Dosche C,L?hmannsr?ben HG,Leimk?hler S

Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.
Proceedings of the National Academy of Sciences of the United States of America108(5)1763-70(2011 Feb)
Van der Veen AG,Schorpp K,Schlieker C,Buti L,Damon JR,Spooner E,Ploegh HL,Jentsch S

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MOCS3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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