RND1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RND1
Entrez Gene ID	27289
Full Name	Rho family GTPase 1
Synonyms	ARHS,RHO6,RHOS
General protein information	Preferred Names Rho family GTPase 1 Names rho-related GTP-binding protein Rho6 ras homolog gene family, member S
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.12
Summary	This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014].
Disorder MIM:	609038

mRNA and Protein(s)

mRNA	Protein	Name
NM_014470.4	NP_055285.1	rho-related GTP-binding protein Rho6 precursor
NM_014470.3	NP_055285.1	rho-related GTP-binding protein Rho6 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RND1	XP_522375.2
Rattus norvegicus (Norway rat)	Rnd1	NP_001013240.1
Danio rerio (zebrafish)	rnd1	NP_998019.3
Bos taurus (cattle)	RND1	NP_001039481.1
Danio rerio (zebrafish)	rnd1l	NP_001037861.1
Xenopus tropicalis (tropical clawed frog)	rnd1	NP_001008073.1
Homo sapiens (human)	RND1	NP_055285.1
Canis lupus familiaris (dog)	RND1	XP_005636950.1
Mus musculus (house mouse)	Rnd1	NP_766200.1

Gene Ontology
Bibliography

Related articles in PubMed

Attenuated RND1 Expression Confers Malignant Phenotype and Predicts Poor Prognosis in Hepatocellular Carcinoma.
Komatsu H, Iguchi T, Masuda T, Hirata H, Ueda M, Kidogami S, Ogawa Y, Sato K, Hu Q, Nambara S, Saito T, Sakimura S, Uchi R, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K
Annals of surgical oncology24(3)850-859(2017 Mar)

Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins.
Wylie T, Garg R, Ridley AJ, Conte MR
PloS one12(10)e0185899(2017)

Modelling GTPase dynamics to understand RhoA-driven cancer cell invasion.
Hetmanski JH, Schwartz JM, Caswell PT
Biochemical Society transactions44(6)1695-1700(2016 12)

RND1 is up-regulated in esophageal squamous cell carcinoma and promotes the growth and migration of cancer cells.
Xiang G, Yi Y, Weiwei H, Weiming W
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(1)773-9(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins shows lack of binding specificity.
Title: Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins.

Studies suggest that Rho GTPase signalling is a complicated mechanism in RhoA-driven cancer cell invasive migration.
Title: Modelling GTPase dynamics to understand RhoA-driven cancer cell invasion.

RND1 plays an important role in the progression of esophageal squamous cell carcinoma
Title: RND1 is up-regulated in esophageal squamous cell carcinoma and promotes the growth and migration of cancer cells.

These results reveal a previously unappreciated mechanism through which Rnd1 restrains activation of Ras-MAPK signalling and breast tumour initiation and progression
Title: The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.

Data indicate that Rnd1 efficiently displaces Rac1 from its complex with Plexin-B1 but not vice versa.
Title: Interaction characteristics of Plexin-B1 with Rho family proteins.

The following RND1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RND1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27141	NM_014470.4 Latest version!	Homo sapiens Rho family GTPase 1 (RND1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu27141	NM_014470.3	Homo sapiens Rho family GTPase 1 (RND1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RND1 ( NM_014470.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055285.1 Homo sapiens Rho family GTPase 1 (RND1), mRNA.

Price & Availability↑

CloneID	OHu27141
Clone ID Related Accession (Same CDS sequence)	NM_014470.4 , NM_014470.3
Accession Version	NM_014470.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein Rho6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC026356.1, AL359573.1 and N79562.1. On Nov 22, 2018 this sequence version replaced NM_014470.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026356.1, SRR3476690.375607.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155984 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000309739.6/ ENSP00000308461.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGGAGA GACGGGCCCC CCAGCCAGTC GTGGCCAGAT GTAAGCTCGT TCTGGTCGGG 
GACGTGCAGT GTGGGAAGAC CGCGATGTTG CAAGTGTTAG CGAAGGATTG CTATCCAGAG 
ACCTATGTGC CCACCGTGTT CGAAAATTAC ACAGCCTGTT TGGAGACAGA GGAACAGAGG 
GTGGAGCTTA GTCTCTGGGA TACCTCAGGA TCTCCCTACT ACGATAATGT CCGTCCACTC 
TGCTACAGCG ACTCGGATGC AGTATTACTA TGTTTTGACA TCAGCCGTCC AGAGACAGTG 
GACAGCGCAC TCAAGAAGTG GAGGACAGAA ATCCTAGATT ATTGTCCCAG CACCCGCGTT 
TTGCTCATTG GCTGCAAGAC AGACCTGCGA ACAGACCTGA GTACTCTGAT GGAGCTGTCC 
CACCAGAAGC AGGCGCCCAT CTCCTATGAG CAGGGTTGTG CAATAGCAAA GCAGCTGGGT 
GCAGAAATCT ACCTGGAAGG CTCAGCTTTC ACCTCAGAAA AGAGCATCCA CAGCATCTTT 
CGGACGGCAT CCATGCTGTG TCTGAACAAG CCTAGCCCAC TGCCCCAGAA GAGCCCTGTC 
CGAAGCCTCT CCAAACGACT GCTCCACCTC CCCAGTCGCT CTGAACTCAT CTCTTCTACC 
TTCAAGAAGG AAAAGGCCAA AAGCTGTTCC ATTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055285.1
CDS	104..802
Translation	MKERRAPQPVVARCKLVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENYTACLETEEQRVELSLWDTSGSPYYDNVRPLCYSDSDAVLLCFDISRPETVDSALKKWRTEILDYCPSTRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLGAEIYLEGSAFTSEKSIHSIFRTASMLCLNKPSPLPQKSPVRSLSKRLLHLPSRSELISSTFKKEKAKSCSIM

Target ORF information:

RefSeq Version	NM_014470.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho family GTPase 1 (RND1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014470.4

ORF Insert Sequence:

ATGAAGGAGA GACGGGCCCC CCAGCCAGTC GTGGCCAGAT GTAAGCTCGT TCTGGTCGGG 
GACGTGCAGT GTGGGAAGAC CGCGATGTTG CAAGTGTTAG CGAAGGATTG CTATCCAGAG 
ACCTATGTGC CCACCGTGTT CGAAAATTAC ACAGCCTGTT TGGAGACAGA GGAACAGAGG 
GTGGAGCTTA GTCTCTGGGA TACCTCAGGA TCTCCCTACT ACGATAATGT CCGTCCACTC 
TGCTACAGCG ACTCGGATGC AGTATTACTA TGTTTTGACA TCAGCCGTCC AGAGACAGTG 
GACAGCGCAC TCAAGAAGTG GAGGACAGAA ATCCTAGATT ATTGTCCCAG CACCCGCGTT 
TTGCTCATTG GCTGCAAGAC AGACCTGCGA ACAGACCTGA GTACTCTGAT GGAGCTGTCC 
CACCAGAAGC AGGCGCCCAT CTCCTATGAG CAGGGTTGTG CAATAGCAAA GCAGCTGGGT 
GCAGAAATCT ACCTGGAAGG CTCAGCTTTC ACCTCAGAAA AGAGCATCCA CAGCATCTTT 
CGGACGGCAT CCATGCTGTG TCTGAACAAG CCTAGCCCAC TGCCCCAGAA GAGCCCTGTC 
CGAAGCCTCT CCAAACGACT GCTCCACCTC CCCAGTCGCT CTGAACTCAT CTCTTCTACC 
TTCAAGAAGG AAAAGGCCAA AAGCTGTTCC ATTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RND1 ( NM_014470.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055285.1 Homo sapiens Rho family GTPase 1 (RND1), mRNA.

Price & Availability↑

CloneID	OHu27141
Clone ID Related Accession (Same CDS sequence)	NM_014470.4 , NM_014470.3
Accession Version	NM_014470.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	rho-related GTP-binding protein Rho6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC026356.1, AL359573.1 and N79562.1. On May 7, 2010 this sequence version replaced NM_014470.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026356.1, U69563.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155984 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGAGA GACGGGCCCC CCAGCCAGTC GTGGCCAGAT GTAAGCTCGT TCTGGTCGGG 
GACGTGCAGT GTGGGAAGAC CGCGATGTTG CAAGTGTTAG CGAAGGATTG CTATCCAGAG 
ACCTATGTGC CCACCGTGTT CGAAAATTAC ACAGCCTGTT TGGAGACAGA GGAACAGAGG 
GTGGAGCTTA GTCTCTGGGA TACCTCAGGA TCTCCCTACT ACGATAATGT CCGTCCACTC 
TGCTACAGCG ACTCGGATGC AGTATTACTA TGTTTTGACA TCAGCCGTCC AGAGACAGTG 
GACAGCGCAC TCAAGAAGTG GAGGACAGAA ATCCTAGATT ATTGTCCCAG CACCCGCGTT 
TTGCTCATTG GCTGCAAGAC AGACCTGCGA ACAGACCTGA GTACTCTGAT GGAGCTGTCC 
CACCAGAAGC AGGCGCCCAT CTCCTATGAG CAGGGTTGTG CAATAGCAAA GCAGCTGGGT 
GCAGAAATCT ACCTGGAAGG CTCAGCTTTC ACCTCAGAAA AGAGCATCCA CAGCATCTTT 
CGGACGGCAT CCATGCTGTG TCTGAACAAG CCTAGCCCAC TGCCCCAGAA GAGCCCTGTC 
CGAAGCCTCT CCAAACGACT GCTCCACCTC CCCAGTCGCT CTGAACTCAT CTCTTCTACC 
TTCAAGAAGG AAAAGGCCAA AAGCTGTTCC ATTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055285.1
CDS	104..802
Translation	MKERRAPQPVVARCKLVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENYTACLETEEQRVELSLWDTSGSPYYDNVRPLCYSDSDAVLLCFDISRPETVDSALKKWRTEILDYCPSTRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLGAEIYLEGSAFTSEKSIHSIFRTASMLCLNKPSPLPQKSPVRSLSKRLLHLPSRSELISSTFKKEKAKSCSIM

Target ORF information:

RefSeq Version	NM_014470.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho family GTPase 1 (RND1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014470.3

ORF Insert Sequence:

ATGAAGGAGA GACGGGCCCC CCAGCCAGTC GTGGCCAGAT GTAAGCTCGT TCTGGTCGGG 
GACGTGCAGT GTGGGAAGAC CGCGATGTTG CAAGTGTTAG CGAAGGATTG CTATCCAGAG 
ACCTATGTGC CCACCGTGTT CGAAAATTAC ACAGCCTGTT TGGAGACAGA GGAACAGAGG 
GTGGAGCTTA GTCTCTGGGA TACCTCAGGA TCTCCCTACT ACGATAATGT CCGTCCACTC 
TGCTACAGCG ACTCGGATGC AGTATTACTA TGTTTTGACA TCAGCCGTCC AGAGACAGTG 
GACAGCGCAC TCAAGAAGTG GAGGACAGAA ATCCTAGATT ATTGTCCCAG CACCCGCGTT 
TTGCTCATTG GCTGCAAGAC AGACCTGCGA ACAGACCTGA GTACTCTGAT GGAGCTGTCC 
CACCAGAAGC AGGCGCCCAT CTCCTATGAG CAGGGTTGTG CAATAGCAAA GCAGCTGGGT 
GCAGAAATCT ACCTGGAAGG CTCAGCTTTC ACCTCAGAAA AGAGCATCCA CAGCATCTTT 
CGGACGGCAT CCATGCTGTG TCTGAACAAG CCTAGCCCAC TGCCCCAGAA GAGCCCTGTC 
CGAAGCCTCT CCAAACGACT GCTCCACCTC CCCAGTCGCT CTGAACTCAT CTCTTCTACC 
TTCAAGAAGG AAAAGGCCAA AAGCTGTTCC ATTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Attenuated RND1 Expression Confers Malignant Phenotype and Predicts Poor Prognosis in Hepatocellular Carcinoma.
Annals of surgical oncology24(3)850-859(2017 Mar)
Komatsu H,Iguchi T,Masuda T,Hirata H,Ueda M,Kidogami S,Ogawa Y,Sato K,Hu Q,Nambara S,Saito T,Sakimura S,Uchi R,Ito S,Eguchi H,Sugimachi K,Eguchi H,Doki Y,Mori M,Mimori K

Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins.
PloS one12(10)e0185899(2017)
Wylie T,Garg R,Ridley AJ,Conte MR

Modelling GTPase dynamics to understand RhoA-driven cancer cell invasion.
Biochemical Society transactions44(6)1695-1700(2016 12)
Hetmanski JH,Schwartz JM,Caswell PT

RND1 is up-regulated in esophageal squamous cell carcinoma and promotes the growth and migration of cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(1)773-9(2016 Jan)
Xiang G,Yi Y,Weiwei H,Weiming W

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RND1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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