LSM1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LSM1
Entrez Gene ID	27257
Full Name	LSM1 homolog, mRNA degradation associated
Synonyms	CASM,YJL124C
General protein information	Preferred Names LSM1 homolog, mRNA degradation associated Names U6 snRNA-associated Sm-like protein LSm1 LSM1 homolog, U6 small nuclear RNA associated LSM1 mRNA degradation associated LSM1, U6 small nuclear RNA associated LSM1-like protein U6 small nuclear RNA associated cancer-associated Sm protein cancer-associated Sm-like protein small nuclear ribonuclear CaSm
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p11.23
Summary	This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011].
Disorder MIM:	607281

mRNA and Protein(s)

mRNA	Protein	Name
NM_014462.3	NP_055277.1	U6 snRNA-associated Sm-like protein LSm1
NM_014462.2	NP_055277.1	U6 snRNA-associated Sm-like protein LSm1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LSM1	XP_532806.3
Bos taurus (cattle)	LSM1	NP_001017952.1
Eremothecium gossypii	AGOS_AFL212C	NP_985338.1
Schizosaccharomyces pombe (fission yeast)	lsm1	NP_595520.1
Arabidopsis thaliana (thale cress)	AT3G14080	NP_850580.1
Homo sapiens (human)	LSM1	NP_055277.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001686	XP_321407.3
Caenorhabditis elegans (roundworm)	lsm-1	NP_496385.1
Mus musculus (house mouse)	Lsm1	NP_080308.1
Rattus norvegicus (Norway rat)	Lsm1	NP_001102346.1
Danio rerio (zebrafish)	lsm1	NP_001003551.1
Drosophila melanogaster (fruit fly)	LSm1	NP_611559.1
Kluyveromyces lactis	KLLA0E15159g	XP_454633.1
Magnaporthe oryzae (rice blast fungus)	MGG_03195	XP_003716791.1
Xenopus tropicalis (tropical clawed frog)	lsm1	NP_001011191.1
Pan troglodytes (chimpanzee)	LSM1	XP_001170479.1
Saccharomyces cerevisiae (baker's yeast)	LSM1	NP_012411.1
Oryza sativa (rice)	Os04g0445800	NP_001052905.1
Gallus gallus (chicken)	LSM1	XP_424387.4

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

LSm1 binds to the Dengue virus RNA 3' UTR and is a positive regulator of Dengue virus replication.
Dong Y, Yang J, Ye W, Wang Y, Miao Y, Ding T, Xiang C, Lei Y, Xu Z
International journal of molecular medicine35(6)1683-9(2015 Jun)

Further evidence for the association between the LSM1 gene and schizophrenia.
Huang L, Hu F, Zeng X, Gan L, Luo XJ
Schizophrenia research150(2-3)588-9(2013 Nov)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results provide evidence that LSm1 binding to the DENV RNA 3' UTR positively regulates DENV RNA replication.
Title: LSm1 binds to the Dengue virus RNA 3' UTR and is a positive regulator of Dengue virus replication.

The results of this study provided further support for previous genetic findings reporting the association of an intronic SNP (rs16887244) in LSM1 and schizophrenia in a Chinese sample
Title: Further evidence for the association between the LSM1 gene and schizophrenia.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Results suggest that LSm-1/CaSm functions as an oncogene in the promotion of cellular transformation and cancer progression.
Title: CaSm (LSm-1) overexpression in lung cancer and mesothelioma is required for transformed phenotypes.

LSM1 is a breast cancer oncogene from the 8p11-12 amplicon.
Title: Transforming function of the LSM1 oncogene in human breast cancers with the 8p11-12 amplicon.

The following LSM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LSM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06398	NM_014462.3 Latest version!	Homo sapiens LSM1 homolog, mRNA degradation associated (LSM1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu06398	NM_014462.2	Homo sapiens LSM1 homolog, mRNA degradation associated (LSM1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LSM1 ( NM_014462.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055277.1 Homo sapiens LSM1 homolog, mRNA degradation associated (LSM1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06398
Clone ID Related Accession (Same CDS sequence)	NM_014462.3 , NM_014462.2
Accession Version	NM_014462.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP376421.1 and AJ238094.1. On Nov 22, 2018 this sequence version replaced NM_014462.2. Transcript Variant: This variant (1) represents the longest transcript and is protein-coding. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ238094.1, SRR5189655.140371.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000311351.9/ ENSP00000310596.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACTATA TGCCTGGCAC CGCCAGCCTC ATCGAGGACA TTGACAAAAA GCACTTGGTT 
CTGCTTCGAG ATGGAAGGAC ACTTATAGGC TTTTTAAGAA GCATTGATCA ATTTGCAAAC 
TTAGTGCTAC ATCAGACTGT GGAGCGTATT CATGTGGGCA AAAAATACGG TGATATTCCT 
CGAGGGATTT TTGTGGTCAG AGGAGAAAAT GTGGTCCTAC TAGGAGAAAT AGACTTGGAA 
AAGGAGAGTG ACACACCCCT CCAGCAAGTA TCCATTGAAG AAATTCTAGA AGAACAAAGG 
GTGGAACAGC AGACCAAGCT GGAAGCAGAG AAGTTGAAAG TGCAGGCCCT GAAGGACCGA 
GGTCTTTCCA TTCCTCGAGC AGATACTCTT GATGAGTACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055277.1
CDS	174..575
Translation	MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTKLEAEKLKVQALKDRGLSIPRADTLDEY

Target ORF information:

RefSeq Version	NM_014462.3
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM1 homolog, mRNA degradation associated (LSM1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014462.3

ORF Insert Sequence:

ATGAACTATA TGCCTGGCAC CGCCAGCCTC ATCGAGGACA TTGACAAAAA GCACTTGGTT 
CTGCTTCGAG ATGGAAGGAC ACTTATAGGC TTTTTAAGAA GCATTGATCA ATTTGCAAAC 
TTAGTGCTAC ATCAGACTGT GGAGCGTATT CATGTGGGCA AAAAATACGG TGATATTCCT 
CGAGGGATTT TTGTGGTCAG AGGAGAAAAT GTGGTCCTAC TAGGAGAAAT AGACTTGGAA 
AAGGAGAGTG ACACACCCCT CCAGCAAGTA TCCATTGAAG AAATTCTAGA AGAACAAAGG 
GTGGAACAGC AGACCAAGCT GGAAGCAGAG AAGTTGAAAG TGCAGGCCCT GAAGGACCGA 
GGTCTTTCCA TTCCTCGAGC AGATACTCTT GATGAGTACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM1 ( NM_014462.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055277.1 Homo sapiens LSM1 homolog, mRNA degradation associated (LSM1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06398
Clone ID Related Accession (Same CDS sequence)	NM_014462.3 , NM_014462.2
Accession Version	NM_014462.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU941962.1, BP376421.1, AJ238094.1 and BE670269.1. On Nov 4, 2011 this sequence version replaced NM_014462.1. Transcript Variant: This variant (1) represents the longest transcript and is protein-coding. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.149829.1, SRR1163658.195264.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACTATA TGCCTGGCAC CGCCAGCCTC ATCGAGGACA TTGACAAAAA GCACTTGGTT 
CTGCTTCGAG ATGGAAGGAC ACTTATAGGC TTTTTAAGAA GCATTGATCA ATTTGCAAAC 
TTAGTGCTAC ATCAGACTGT GGAGCGTATT CATGTGGGCA AAAAATACGG TGATATTCCT 
CGAGGGATTT TTGTGGTCAG AGGAGAAAAT GTGGTCCTAC TAGGAGAAAT AGACTTGGAA 
AAGGAGAGTG ACACACCCCT CCAGCAAGTA TCCATTGAAG AAATTCTAGA AGAACAAAGG 
GTGGAACAGC AGACCAAGCT GGAAGCAGAG AAGTTGAAAG TGCAGGCCCT GAAGGACCGA 
GGTCTTTCCA TTCCTCGAGC AGATACTCTT GATGAGTACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055277.1
CDS	411..812
Translation	MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTKLEAEKLKVQALKDRGLSIPRADTLDEY

Target ORF information:

RefSeq Version	NM_014462.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM1 homolog, mRNA degradation associated (LSM1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014462.2

ORF Insert Sequence:

ATGAACTATA TGCCTGGCAC CGCCAGCCTC ATCGAGGACA TTGACAAAAA GCACTTGGTT 
CTGCTTCGAG ATGGAAGGAC ACTTATAGGC TTTTTAAGAA GCATTGATCA ATTTGCAAAC 
TTAGTGCTAC ATCAGACTGT GGAGCGTATT CATGTGGGCA AAAAATACGG TGATATTCCT 
CGAGGGATTT TTGTGGTCAG AGGAGAAAAT GTGGTCCTAC TAGGAGAAAT AGACTTGGAA 
AAGGAGAGTG ACACACCCCT CCAGCAAGTA TCCATTGAAG AAATTCTAGA AGAACAAAGG 
GTGGAACAGC AGACCAAGCT GGAAGCAGAG AAGTTGAAAG TGCAGGCCCT GAAGGACCGA 
GGTCTTTCCA TTCCTCGAGC AGATACTCTT GATGAGTACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

LSm1 binds to the Dengue virus RNA 3' UTR and is a positive regulator of Dengue virus replication.
International journal of molecular medicine35(6)1683-9(2015 Jun)
Dong Y,Yang J,Ye W,Wang Y,Miao Y,Ding T,Xiang C,Lei Y,Xu Z

Further evidence for the association between the LSM1 gene and schizophrenia.
Schizophrenia research150(2-3)588-9(2013 Nov)
Huang L,Hu F,Zeng X,Gan L,Luo XJ

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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LSM1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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