IL17C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL17C
Entrez Gene ID	27189
Full Name	interleukin 17C
Synonyms	CX2,IL-17C
General protein information	Preferred Names interleukin 17C Names interleukin-17C cytokine CX2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q24.2
Summary	The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008].
Disorder MIM:	604628

mRNA and Protein(s)

mRNA	Protein	Name
NM_013278.4	NP_037410.1	interleukin-17C precursor
NM_013278.3	NP_037410.1	interleukin-17C precursor

Pathways from BioSystems

Homologies

	LOC710618	XP_001099282.2
Pan troglodytes (chimpanzee)	IL17C	XP_523458.2
Homo sapiens (human)	IL17C	NP_037410.1
Xenopus tropicalis (tropical clawed frog)	il17c	XP_002942041.2
Mus musculus (house mouse)	Il17c	NP_665833.3
Rattus norvegicus (Norway rat)	Il17c	NP_001178044.1

Gene Ontology
Bibliography

Related articles in PubMed

Interleukin-17C in Human Helicobacter pylori Gastritis.
Tanaka S, Nagashima H, Cruz M, Uchida T, Uotani T, Jim?nez Abreu JA, Mahachai V, Vilaichone RK, Ratanachu-Ek T, Tshering L, Graham DY, Yamaoka Y
Infection and immunity85(10)(2017 Oct)

IL-17C mediates the recruitment of tumor-associated neutrophils and lung tumor growth.
Jungnickel C, Schmidt LH, Bittigkoffer L, Wolf L, Wolf A, Ritzmann F, Kamyschnikow A, Herr C, Menger MD, Spieker T, Wiewrodt R, Bals R, Beisswenger C
Oncogene36(29)4182-4190(2017 Jul)

Interleukin-9 and interleukin-17C in chronic rhinosinusitis.
Olcott CM, Han JK, Cunningham TD, Franzese CB
International forum of allergy & rhinology6(8)841-7(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Helicobacter pylori infection was associated with a significant increase in IL-17C expression in gastric mucosa. The role of IL-17C in the pathogenesis of H. pylori-induced diseases remains to be determined.
Title: Interleukin-17C in Human Helicobacter pylori Gastritis.

Data indicate that epithelial IL-17C promotes neutrophilic inflammation in the tumor microenvironment and suggest that IL-17C links a pathologic microbiota, as present in COPD patients, with enhanced tumor growth.
Title: IL-17C mediates the recruitment of tumor-associated neutrophils and lung tumor growth.

Inflammatory cell expression of IL-9 and IL-17C were increased in chronic rhinosinusitis, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of chronic rhinosinusitis with nasal polyps as well as atopy and may serve as therapeutic targets for disease management
Title: Interleukin-9 and interleukin-17C in chronic rhinosinusitis.

CpG methylation is reduced in gingival biopsies of patients with periodontitis
Title: Epigenetic characteristics in inflammatory candidate genes in aggressive periodontitis.

Those carrying rs3748067 CC genotype and C allele had a significantly increased risk for the development of gastric cancer
Title: IL-17 gene polymorphism is associated with susceptibility to gastric cancer.

The following IL17C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL17C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17305	NM_013278.4 Latest version!	Homo sapiens interleukin 17C (IL17C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17305	NM_013278.3	Homo sapiens interleukin 17C (IL17C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL17C ( NM_013278.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037410.1 Homo sapiens interleukin 17C (IL17C), mRNA.

Price & Availability↑

CloneID	OHu17305
Clone ID Related Accession (Same CDS sequence)	NM_013278.4 , NM_013278.3
Accession Version	NM_013278.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	interleukin-17C precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC116552.2. On May 17, 2019 this sequence version replaced NM_013278.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358471.1, AF152099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2163459 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244241.5/ ENSP00000244241.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACGCTCC TCCCCGGCCT CCTGTTTCTG ACCTGGCTGC ACACATGCCT GGCCCACCAT 
GACCCCTCCC TCAGGGGGCA CCCCCACAGT CACGGTACCC CACACTGCTA CTCGGCTGAG 
GAACTGCCCC TCGGCCAGGC CCCCCCACAC CTGCTGGCTC GAGGTGCCAA GTGGGGGCAG 
GCTTTGCCTG TAGCCCTGGT GTCCAGCCTG GAGGCAGCAA GCCACAGGGG GAGGCACGAG 
AGGCCCTCAG CTACGACCCA GTGCCCGGTG CTGCGGCCGG AGGAGGTGTT GGAGGCAGAC 
ACCCACCAGC GCTCCATCTC ACCCTGGAGA TACCGTGTGG ACACGGATGA GGACCGCTAT 
CCACAGAAGC TGGCCTTCGC CGAGTGCCTG TGCAGAGGCT GTATCGATGC ACGGACGGGC 
CGCGAGACAG CTGCGCTCAA CTCCGTGCGG CTGCTCCAGA GCCTGCTGGT GCTGCGCCGC 
CGGCCCTGCT CCCGCGACGG CTCGGGGCTC CCCACACCTG GGGCCTTTGC CTTCCACACC 
GAGTTCATCC ACGTCCCCGT CGGCTGCACC TGCGTGCTGC CCCGTTCAGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037410.1
CDS	71..664
Translation	MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRYPQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIHVPVGCTCVLPRSV

Target ORF information:

RefSeq Version	NM_013278.4
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 17C (IL17C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013278.4

ORF Insert Sequence:

ATGACGCTCC TCCCCGGCCT CCTGTTTCTG ACCTGGCTGC ACACATGCCT GGCCCACCAT 
GACCCCTCCC TCAGGGGGCA CCCCCACAGT CACGGTACCC CACACTGCTA CTCGGCTGAG 
GAACTGCCCC TCGGCCAGGC CCCCCCACAC CTGCTGGCTC GAGGTGCCAA GTGGGGGCAG 
GCTTTGCCTG TAGCCCTGGT GTCCAGCCTG GAGGCAGCAA GCCACAGGGG GAGGCACGAG 
AGGCCCTCAG CTACGACCCA GTGCCCGGTG CTGCGGCCGG AGGAGGTGTT GGAGGCAGAC 
ACCCACCAGC GCTCCATCTC ACCCTGGAGA TACCGTGTGG ACACGGATGA GGACCGCTAT 
CCACAGAAGC TGGCCTTCGC CGAGTGCCTG TGCAGAGGCT GTATCGATGC ACGGACGGGC 
CGCGAGACAG CTGCGCTCAA CTCCGTGCGG CTGCTCCAGA GCCTGCTGGT GCTGCGCCGC 
CGGCCCTGCT CCCGCGACGG CTCGGGGCTC CCCACACCTG GGGCCTTTGC CTTCCACACC 
GAGTTCATCC ACGTCCCCGT CGGCTGCACC TGCGTGCTGC CCCGTTCAGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL17C ( NM_013278.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037410.1 Homo sapiens interleukin 17C (IL17C), mRNA.

Price & Availability↑

CloneID	OHu17305
Clone ID Related Accession (Same CDS sequence)	NM_013278.4 , NM_013278.3
Accession Version	NM_013278.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-18
Organism	Homo sapiens(human)
Product	interleukin-17C precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF152099.1. On Jan 3, 2003 this sequence version replaced NM_013278.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF152099.1, BC101835.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2163459 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGCTCC TCCCCGGCCT CCTGTTTCTG ACCTGGCTGC ACACATGCCT GGCCCACCAT 
GACCCCTCCC TCAGGGGGCA CCCCCACAGT CACGGTACCC CACACTGCTA CTCGGCTGAG 
GAACTGCCCC TCGGCCAGGC CCCCCCACAC CTGCTGGCTC GAGGTGCCAA GTGGGGGCAG 
GCTTTGCCTG TAGCCCTGGT GTCCAGCCTG GAGGCAGCAA GCCACAGGGG GAGGCACGAG 
AGGCCCTCAG CTACGACCCA GTGCCCGGTG CTGCGGCCGG AGGAGGTGTT GGAGGCAGAC 
ACCCACCAGC GCTCCATCTC ACCCTGGAGA TACCGTGTGG ACACGGATGA GGACCGCTAT 
CCACAGAAGC TGGCCTTCGC CGAGTGCCTG TGCAGAGGCT GTATCGATGC ACGGACGGGC 
CGCGAGACAG CTGCGCTCAA CTCCGTGCGG CTGCTCCAGA GCCTGCTGGT GCTGCGCCGC 
CGGCCCTGCT CCCGCGACGG CTCGGGGCTC CCCACACCTG GGGCCTTTGC CTTCCACACC 
GAGTTCATCC ACGTCCCCGT CGGCTGCACC TGCGTGCTGC CCCGTTCAGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037410.1
CDS	50..643
Translation	MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRYPQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIHVPVGCTCVLPRSV

Target ORF information:

RefSeq Version	NM_013278.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 17C (IL17C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013278.3

ORF Insert Sequence:

ATGACGCTCC TCCCCGGCCT CCTGTTTCTG ACCTGGCTGC ACACATGCCT GGCCCACCAT 
GACCCCTCCC TCAGGGGGCA CCCCCACAGT CACGGTACCC CACACTGCTA CTCGGCTGAG 
GAACTGCCCC TCGGCCAGGC CCCCCCACAC CTGCTGGCTC GAGGTGCCAA GTGGGGGCAG 
GCTTTGCCTG TAGCCCTGGT GTCCAGCCTG GAGGCAGCAA GCCACAGGGG GAGGCACGAG 
AGGCCCTCAG CTACGACCCA GTGCCCGGTG CTGCGGCCGG AGGAGGTGTT GGAGGCAGAC 
ACCCACCAGC GCTCCATCTC ACCCTGGAGA TACCGTGTGG ACACGGATGA GGACCGCTAT 
CCACAGAAGC TGGCCTTCGC CGAGTGCCTG TGCAGAGGCT GTATCGATGC ACGGACGGGC 
CGCGAGACAG CTGCGCTCAA CTCCGTGCGG CTGCTCCAGA GCCTGCTGGT GCTGCGCCGC 
CGGCCCTGCT CCCGCGACGG CTCGGGGCTC CCCACACCTG GGGCCTTTGC CTTCCACACC 
GAGTTCATCC ACGTCCCCGT CGGCTGCACC TGCGTGCTGC CCCGTTCAGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interleukin-17C in Human Helicobacter pylori Gastritis.
Infection and immunity85(10)(2017 Oct)
Tanaka S,Nagashima H,Cruz M,Uchida T,Uotani T,Jim?nez Abreu JA,Mahachai V,Vilaichone RK,Ratanachu-Ek T,Tshering L,Graham DY,Yamaoka Y

IL-17C mediates the recruitment of tumor-associated neutrophils and lung tumor growth.
Oncogene36(29)4182-4190(2017 Jul)
Jungnickel C,Schmidt LH,Bittigkoffer L,Wolf L,Wolf A,Ritzmann F,Kamyschnikow A,Herr C,Menger MD,Spieker T,Wiewrodt R,Bals R,Beisswenger C

Interleukin-9 and interleukin-17C in chronic rhinosinusitis.
International forum of allergy & rhinology6(8)841-7(2016 08)
Olcott CM,Han JK,Cunningham TD,Franzese CB

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IL17C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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