VPS4A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VPS4A
Entrez Gene ID	27183
Full Name	vacuolar protein sorting 4 homolog A
Synonyms	SKD1,SKD1A,SKD2,VPS4,VPS4-1
General protein information	Preferred Names vacuolar protein sorting 4 homolog A Names vacuolar protein sorting-associated protein 4A SKD1-homolog hVPS4 vacuolar protein sorting factor 4A vacuolar sorting protein 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q22.1
Summary	The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008].
Disorder MIM:	609982

mRNA and Protein(s)

mRNA	Protein	Name
NM_013245.3	NP_037377.1	vacuolar protein sorting-associated protein 4A
NM_013245.2	NP_037377.1	vacuolar protein sorting-associated protein 4A

Pathways from BioSystems

Homologies

	VPS4A	XP_001093648.2
Canis lupus familiaris (dog)	VPS4A	XP_536805.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000625	XP_310453.2
Rattus norvegicus (Norway rat)	Vps4a	NP_663711.1
Homo sapiens (human)	VPS4A	NP_037377.1
Mus musculus (house mouse)	Vps4a	NP_569053.1
Xenopus tropicalis (tropical clawed frog)	vps4a	XP_004915415.1
Gallus gallus (chicken)	VPS4A	XP_423372.4
Danio rerio (zebrafish)	vps4a	NP_001070077.1
Pan troglodytes (chimpanzee)	VPS4A	XP_001147558.3
Drosophila melanogaster (fruit fly)	Vps4	NP_573258.1

Gene Ontology
Bibliography

Related articles in PubMed

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis.
Mierzwa BE, Chiaruttini N, Redondo-Morata L, von Filseck JM, K?nig J, Larios J, Poser I, M?ller-Reichert T, Scheuring S, Roux A, Gerlich DW
Nature cell biology19(7)787-798(2017 Jul)

The VPS4 component of the ESCRT machinery plays an essential role in HPV infectious entry and capsid disassembly.
Broniarczyk J, Pim D, Massimi P, Bergant M, Go?dzicka-J?zefiak A, Crump C, Banks L
Scientific reports745159(2017 Mar)

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.
Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A
Proceedings of the National Academy of Sciences of the United States of America114(11)E2166-E2175(2017 Mar)

Neural basis of reward anticipation and its genetic determinants.
Jia T, Macare C, Desrivi?res S, Gonzalez DA, Tao C, Ji X, Ruggeri B, Nees F, Banaschewski T, Barker GJ, Bokde AL, Bromberg U, B?chel C, Conrod PJ, Dove R, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lemaitre H, Martinot JL, Paus T, Pausova Z, Poline JB, Rietschel M, Robbins T, Smolka MN, M?ller CP, Feng J, Rothenfluh A, Flor H, Schumann G,
Proceedings of the National Academy of Sciences of the United States of America113(14)3879-84(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Continuous ESCRT-III remodelling by dynamic subunit turnover is regulated by Vps4 to mediate membrane remodelling during cytokinesis.
Title: Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis.

associations were noted between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila
Title: Neural basis of reward anticipation and its genetic determinants.

These results point to the existence of previously undetected biological functions of the FTase alpha subunit that includes control of intracellular membrane trafficking.
Title: Mammalian farnesyltransferase ? subunit regulates vacuolar protein sorting-associated protein 4A (Vps4A)--dependent intracellular trafficking through recycling endosomes.

Vps4A may function as a tumor suppressor, which utilizes exosomes as mediators to regulate the secretion and uptake of miRNAs in hepatoma cells; these observations provide new insights into the development of HCC.
Title: Vps4A functions as a tumor suppressor by regulating the secretion and uptake of exosomal microRNAs in human hepatoma cells.

Ca2+-dependent accumulation of ESCRT III-Vps4 complex following large focal injury to the cell membrane and identify the role of ALG-2 as the initiator of sequential ESCRT III-Vps4A/B complex assembly.
Title: Mechanism of Ca??-triggered ESCRT assembly and regulation of cell membrane repair.

The following VPS4A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VPS4A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29840	NM_013245.3 Latest version!	Homo sapiens vacuolar protein sorting 4 homolog A (VPS4A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu29840	NM_013245.2	Homo sapiens vacuolar protein sorting 4 homolog A (VPS4A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VPS4A ( NM_013245.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037377.1 Homo sapiens vacuolar protein sorting 4 homolog A (VPS4A), mRNA.

Price & Availability↑

CloneID	OHu29840
Clone ID Related Accession (Same CDS sequence)	NM_013245.3 , NM_013245.2
Accession Version	NM_013245.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1314bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	vacuolar protein sorting-associated protein 4A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC026464.7 and AF255952.1. On Nov 22, 2018 this sequence version replaced NM_013245.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.66661.1, SRR1803617.226430.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000254950.13/ ENSP00000254950.11 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACAACGT CAACCCTCCA GAAAGCCATT GATCTGGTGA CGAAAGCCAC AGAGGAGGAC 
AAAGCCAAGA ACTACGAGGA GGCGCTGCGG CTGTACCAGC ATGCGGTGGA GTACTTCCTC 
CACGCTATCA AGTATGAGGC CCACAGCGAC AAGGCCAAGG AGAGCATTCG AGCCAAGTGC 
GTGCAGTACC TAGACCGGGC CGAGAAGCTG AAGGATTATT TACGAAGCAA AGAGAAACAC 
GGCAAGAAGC CAGTCAAAGA GAACCAGAGT GAGGGCAAGG GCAGTGACAG TGACAGTGAA 
GGGGATAATC CGGAGAAAAA GAAACTGCAA GAACAGCTGA TGGGTGCCGT CGTGATGGAG 
AAGCCCAACA TACGGTGGAA CGACGTGGCC GGGCTGGAGG GGGCCAAGGA GGCCCTCAAA 
GAAGCTGTCA TTTTGCCAAT CAAATTCCCA CACTTGTTCA CAGGCAAGCG CACCCCCTGG 
CGGGGGATTC TGCTGTTCGG ACCCCCTGGC ACAGGGAAAT CCTACCTGGC CAAAGCCGTG 
GCAACAGAGG CCAACAACTC CACCTTCTTC TCTGTGTCCT CCTCAGATCT GATGTCCAAG 
TGGCTGGGGG AGAGTGAAAA GCTGGTCAAG AACCTGTTTG AGCTGGCCAG GCAGCACAAG 
CCCTCCATCA TCTTCATCGA TGAGGTGGAT TCCCTCTGCG GGTCCCGAAA TGAAAATGAG 
AGTGAGGCCG CCCGGAGGAT CAAAACGGAG TTCTTGGTCC AGATGCAGGG GGTGGGGAAT 
AACAATGATG GGACTCTGGT TCTTGGAGCC ACAAACATCC CATGGGTGTT GGATTCGGCC 
ATCAGGAGGA GGTTTGAAAA ACGAATTTAT ATCCCCTTGC CGGAGGAAGC TGCCCGCGCC 
CAGATGTTCC GGTTGCATCT CGGGAGCACT CCCCACAACC TCACGGATGC AAACATCCAC 
GAGCTGGCCC GGAAGACGGA AGGCTACTCG GGCGCGGACA TCAGCATCAT CGTGCGGGAC 
TCTCTCATGC AGCCCGTGAG GAAGGTGCAG TCGGCCACAC ACTTCAAAAA GGTCTGTGGC 
CCCTCTCGCA CCAACCCCAG CATGATGATT GATGACCTCC TGACTCCATG CTCACCAGGG 
GACCCAGGAG CCATGGAGAT GACTTGGATG GATGTCCCTG GGGACAAACT CTTAGAGCCT 
GTGGTTTGCA TGTCGGACAT GCTGCGGTCT CTGGCCACCA CCCGGCCCAC GGTGAATGCA 
GACGACCTCC TGAAAGTGAA GAAATTCTCA GAGGACTTTG GGCAAGAGAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037377.1
CDS	163..1476
Translation	MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCVQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES

Target ORF information:

RefSeq Version	NM_013245.3
Organism	Homo sapiens(human)
Definition	Homo sapiens vacuolar protein sorting 4 homolog A (VPS4A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013245.3

ORF Insert Sequence:

ATGACAACGT CAACCCTCCA GAAAGCCATT GATCTGGTGA CGAAAGCCAC AGAGGAGGAC 
AAAGCCAAGA ACTACGAGGA GGCGCTGCGG CTGTACCAGC ATGCGGTGGA GTACTTCCTC 
CACGCTATCA AGTATGAGGC CCACAGCGAC AAGGCCAAGG AGAGCATTCG AGCCAAGTGC 
GTGCAGTACC TAGACCGGGC CGAGAAGCTG AAGGATTATT TACGAAGCAA AGAGAAACAC 
GGCAAGAAGC CAGTCAAAGA GAACCAGAGT GAGGGCAAGG GCAGTGACAG TGACAGTGAA 
GGGGATAATC CGGAGAAAAA GAAACTGCAA GAACAGCTGA TGGGTGCCGT CGTGATGGAG 
AAGCCCAACA TACGGTGGAA CGACGTGGCC GGGCTGGAGG GGGCCAAGGA GGCCCTCAAA 
GAAGCTGTCA TTTTGCCAAT CAAATTCCCA CACTTGTTCA CAGGCAAGCG CACCCCCTGG 
CGGGGGATTC TGCTGTTCGG ACCCCCTGGC ACAGGGAAAT CCTACCTGGC CAAAGCCGTG 
GCAACAGAGG CCAACAACTC CACCTTCTTC TCTGTGTCCT CCTCAGATCT GATGTCCAAG 
TGGCTGGGGG AGAGTGAAAA GCTGGTCAAG AACCTGTTTG AGCTGGCCAG GCAGCACAAG 
CCCTCCATCA TCTTCATCGA TGAGGTGGAT TCCCTCTGCG GGTCCCGAAA TGAAAATGAG 
AGTGAGGCCG CCCGGAGGAT CAAAACGGAG TTCTTGGTCC AGATGCAGGG GGTGGGGAAT 
AACAATGATG GGACTCTGGT TCTTGGAGCC ACAAACATCC CATGGGTGTT GGATTCGGCC 
ATCAGGAGGA GGTTTGAAAA ACGAATTTAT ATCCCCTTGC CGGAGGAAGC TGCCCGCGCC 
CAGATGTTCC GGTTGCATCT CGGGAGCACT CCCCACAACC TCACGGATGC AAACATCCAC 
GAGCTGGCCC GGAAGACGGA AGGCTACTCG GGCGCGGACA TCAGCATCAT CGTGCGGGAC 
TCTCTCATGC AGCCCGTGAG GAAGGTGCAG TCGGCCACAC ACTTCAAAAA GGTCTGTGGC 
CCCTCTCGCA CCAACCCCAG CATGATGATT GATGACCTCC TGACTCCATG CTCACCAGGG 
GACCCAGGAG CCATGGAGAT GACTTGGATG GATGTCCCTG GGGACAAACT CTTAGAGCCT 
GTGGTTTGCA TGTCGGACAT GCTGCGGTCT CTGGCCACCA CCCGGCCCAC GGTGAATGCA 
GACGACCTCC TGAAAGTGAA GAAATTCTCA GAGGACTTTG GGCAAGAGAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VPS4A ( NM_013245.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_037377.1 Homo sapiens vacuolar protein sorting 4 homolog A (VPS4A), mRNA.

Price & Availability↑

CloneID	OHu29840
Clone ID Related Accession (Same CDS sequence)	NM_013245.3 , NM_013245.2
Accession Version	NM_013245.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1314bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	vacuolar protein sorting-associated protein 4A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF255952.1. On Dec 17, 2001 this sequence version replaced NM_013245.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF255952.1, SRR1660803.57424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAACGT CAACCCTCCA GAAAGCCATT GATCTGGTGA CGAAAGCCAC AGAGGAGGAC 
AAAGCCAAGA ACTACGAGGA GGCGCTGCGG CTGTACCAGC ATGCGGTGGA GTACTTCCTC 
CACGCTATCA AGTATGAGGC CCACAGCGAC AAGGCCAAGG AGAGCATTCG AGCCAAGTGC 
GTGCAGTACC TAGACCGGGC CGAGAAGCTG AAGGATTATT TACGAAGCAA AGAGAAACAC 
GGCAAGAAGC CAGTCAAAGA GAACCAGAGT GAGGGCAAGG GCAGTGACAG TGACAGTGAA 
GGGGATAATC CGGAGAAAAA GAAACTGCAA GAACAGCTGA TGGGTGCCGT CGTGATGGAG 
AAGCCCAACA TACGGTGGAA CGACGTGGCC GGGCTGGAGG GGGCCAAGGA GGCCCTCAAA 
GAAGCTGTCA TTTTGCCAAT CAAATTCCCA CACTTGTTCA CAGGCAAGCG CACCCCCTGG 
CGGGGGATTC TGCTGTTCGG ACCCCCTGGC ACAGGGAAAT CCTACCTGGC CAAAGCCGTG 
GCAACAGAGG CCAACAACTC CACCTTCTTC TCTGTGTCCT CCTCAGATCT GATGTCCAAG 
TGGCTGGGGG AGAGTGAAAA GCTGGTCAAG AACCTGTTTG AGCTGGCCAG GCAGCACAAG 
CCCTCCATCA TCTTCATCGA TGAGGTGGAT TCCCTCTGCG GGTCCCGAAA TGAAAATGAG 
AGTGAGGCCG CCCGGAGGAT CAAAACGGAG TTCTTGGTCC AGATGCAGGG GGTGGGGAAT 
AACAATGATG GGACTCTGGT TCTTGGAGCC ACAAACATCC CATGGGTGTT GGATTCGGCC 
ATCAGGAGGA GGTTTGAAAA ACGAATTTAT ATCCCCTTGC CGGAGGAAGC TGCCCGCGCC 
CAGATGTTCC GGTTGCATCT CGGGAGCACT CCCCACAACC TCACGGATGC AAACATCCAC 
GAGCTGGCCC GGAAGACGGA AGGCTACTCG GGCGCGGACA TCAGCATCAT CGTGCGGGAC 
TCTCTCATGC AGCCCGTGAG GAAGGTGCAG TCGGCCACAC ACTTCAAAAA GGTCTGTGGC 
CCCTCTCGCA CCAACCCCAG CATGATGATT GATGACCTCC TGACTCCATG CTCACCAGGG 
GACCCAGGAG CCATGGAGAT GACTTGGATG GATGTCCCTG GGGACAAACT CTTAGAGCCT 
GTGGTTTGCA TGTCGGACAT GCTGCGGTCT CTGGCCACCA CCCGGCCCAC GGTGAATGCA 
GACGACCTCC TGAAAGTGAA GAAATTCTCA GAGGACTTTG GGCAAGAGAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037377.1
CDS	129..1442
Translation	MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCVQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES

Target ORF information:

RefSeq Version	NM_013245.2
Organism	Homo sapiens(human)
Definition	Homo sapiens vacuolar protein sorting 4 homolog A (VPS4A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013245.2

ORF Insert Sequence:

ATGACAACGT CAACCCTCCA GAAAGCCATT GATCTGGTGA CGAAAGCCAC AGAGGAGGAC 
AAAGCCAAGA ACTACGAGGA GGCGCTGCGG CTGTACCAGC ATGCGGTGGA GTACTTCCTC 
CACGCTATCA AGTATGAGGC CCACAGCGAC AAGGCCAAGG AGAGCATTCG AGCCAAGTGC 
GTGCAGTACC TAGACCGGGC CGAGAAGCTG AAGGATTATT TACGAAGCAA AGAGAAACAC 
GGCAAGAAGC CAGTCAAAGA GAACCAGAGT GAGGGCAAGG GCAGTGACAG TGACAGTGAA 
GGGGATAATC CGGAGAAAAA GAAACTGCAA GAACAGCTGA TGGGTGCCGT CGTGATGGAG 
AAGCCCAACA TACGGTGGAA CGACGTGGCC GGGCTGGAGG GGGCCAAGGA GGCCCTCAAA 
GAAGCTGTCA TTTTGCCAAT CAAATTCCCA CACTTGTTCA CAGGCAAGCG CACCCCCTGG 
CGGGGGATTC TGCTGTTCGG ACCCCCTGGC ACAGGGAAAT CCTACCTGGC CAAAGCCGTG 
GCAACAGAGG CCAACAACTC CACCTTCTTC TCTGTGTCCT CCTCAGATCT GATGTCCAAG 
TGGCTGGGGG AGAGTGAAAA GCTGGTCAAG AACCTGTTTG AGCTGGCCAG GCAGCACAAG 
CCCTCCATCA TCTTCATCGA TGAGGTGGAT TCCCTCTGCG GGTCCCGAAA TGAAAATGAG 
AGTGAGGCCG CCCGGAGGAT CAAAACGGAG TTCTTGGTCC AGATGCAGGG GGTGGGGAAT 
AACAATGATG GGACTCTGGT TCTTGGAGCC ACAAACATCC CATGGGTGTT GGATTCGGCC 
ATCAGGAGGA GGTTTGAAAA ACGAATTTAT ATCCCCTTGC CGGAGGAAGC TGCCCGCGCC 
CAGATGTTCC GGTTGCATCT CGGGAGCACT CCCCACAACC TCACGGATGC AAACATCCAC 
GAGCTGGCCC GGAAGACGGA AGGCTACTCG GGCGCGGACA TCAGCATCAT CGTGCGGGAC 
TCTCTCATGC AGCCCGTGAG GAAGGTGCAG TCGGCCACAC ACTTCAAAAA GGTCTGTGGC 
CCCTCTCGCA CCAACCCCAG CATGATGATT GATGACCTCC TGACTCCATG CTCACCAGGG 
GACCCAGGAG CCATGGAGAT GACTTGGATG GATGTCCCTG GGGACAAACT CTTAGAGCCT 
GTGGTTTGCA TGTCGGACAT GCTGCGGTCT CTGGCCACCA CCCGGCCCAC GGTGAATGCA 
GACGACCTCC TGAAAGTGAA GAAATTCTCA GAGGACTTTG GGCAAGAGAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis.
Nature cell biology19(7)787-798(2017 Jul)
Mierzwa BE,Chiaruttini N,Redondo-Morata L,von Filseck JM,K?nig J,Larios J,Poser I,M?ller-Reichert T,Scheuring S,Roux A,Gerlich DW

The VPS4 component of the ESCRT machinery plays an essential role in HPV infectious entry and capsid disassembly.
Scientific reports745159(2017 Mar)
Broniarczyk J,Pim D,Massimi P,Bergant M,Go?dzicka-J?zefiak A,Crump C,Banks L

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.
Proceedings of the National Academy of Sciences of the United States of America114(11)E2166-E2175(2017 Mar)
Gu M,LaJoie D,Chen OS,von Appen A,Ladinsky MS,Redd MJ,Nikolova L,Bjorkman PJ,Sundquist WI,Ullman KS,Frost A

Neural basis of reward anticipation and its genetic determinants.
Proceedings of the National Academy of Sciences of the United States of America113(14)3879-84(2016 Apr)
Jia T,Macare C,Desrivi?res S,Gonzalez DA,Tao C,Ji X,Ruggeri B,Nees F,Banaschewski T,Barker GJ,Bokde AL,Bromberg U,B?chel C,Conrod PJ,Dove R,Frouin V,Gallinat J,Garavan H,Gowland PA,Heinz A,Ittermann B,Lathrop M,Lemaitre H,Martinot JL,Paus T,Pausova Z,Poline JB,Rietschel M,Robbins T,Smolka MN,M?ller CP,Feng J,Rothenfluh A,Flor H,Schumann G,

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VPS4A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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