KCNH5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNH5
Entrez Gene ID	27133
Full Name	potassium voltage-gated channel subfamily H member 5
Synonyms	EAG2,H-EAG2,Kv10.2,hEAG2
General protein information	Preferred Names potassium voltage-gated channel subfamily H member 5 Names potassium voltage-gated channel subfamily H member 5 ether-a-go-go-related potassium channel 2 potassium channel, voltage gated eag related subfamily H, member 5 potassium voltage-gated channel, subfamily H (eag-related), member 5 voltage-gated potassium channel subunit Kv10.2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q23.2
Summary	This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Disorder MIM:	605716

mRNA and Protein(s)

mRNA	Protein	Name
NM_172375.2	NP_758963.1	potassium voltage-gated channel subfamily H member 5 isoform 3
NM_139318.5	NP_647479.2	potassium voltage-gated channel subfamily H member 5 isoform 1
NM_139318.4	NP_647479.2	potassium voltage-gated channel subfamily H member 5 isoform 1
NM_172375.3	NP_758963.1	potassium voltage-gated channel subfamily H member 5 isoform 3

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	KCNH5	XP_421414.2
Xenopus tropicalis (tropical clawed frog)	kcnh5	NP_001120909.1
Mus musculus (house mouse)	Kcnh5	NP_766393.2
Bos taurus (cattle)	KCNH5	NP_001179918.1
Homo sapiens (human)	KCNH5	NP_647479.2
	KCNH5	XP_001100052.1
Canis lupus familiaris (dog)	KCNH5	XP_547846.2
Rattus norvegicus (Norway rat)	Kcnh5	NP_598294.1
Danio rerio (zebrafish)	kcnh5a	NP_001263209.1

Gene Ontology
Bibliography

Related articles in PubMed

Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.
Li X, Anishkin A, Liu H, van Rossum DB, Chintapalli SV, Sassic JK, Gallegos D, Pivaroff-Ward K, Jegla T
The Journal of general physiology146(5)357-74(2015 Nov)

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY
Nature neuroscience18(9)1236-46(2015 Sep)

A sustained increase in the intracellular Ca?? concentration induces proteolytic cleavage of EAG2 channel.
Shimizu N, Sato N, Kikuchi T, Ishizaki T, Kobayashi K, Kita K, Takimoto K
The international journal of biochemistry & cell biology59126-34(2015 Feb)

The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.
Patel YM, Stram DO, Wilkens LR, Park SS, Henderson BE, Le Marchand L, Haiman CA, Murphy SE
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology24(1)119-27(2015 Jan)

Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene.
Macaulay EC, Roberts HE, Cheng X, Jeffs AR, Baguley BC, Morison IM
PloS one9(4)e95840(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

EAG2 potassium channel has an evolutionarily conserved function for promoting brain tumor growth.
Title: EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.

The observed Ca(2+)-induced proteolytic cleavage of EAG2 channel may act as an adaptive response under physiological and/or pathological conditions.
Title: A sustained increase in the intracellular Ca?? concentration induces proteolytic cleavage of EAG2 channel.

Study propose that hypomethylation of the placental-specific KCNH5 promoter is frequently associated with KCNH5 expression in melanoma cells.
Title: Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene.

Our results demonstrate the critical role of the Arg327 residue in stabilizing the channel closed state and explicate for the first time the structural and functional change of a Kv10.2 channel mutation associated with neurological disease.
Title: Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state.

This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans.
Title: Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.

The following KCNH5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNH5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13011	NM_172375.3 Latest version!	Homo sapiens potassium voltage-gated channel subfamily H member 5 (KCNH5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu22064	NM_139318.5 Latest version!	Homo sapiens potassium voltage-gated channel subfamily H member 5 (KCNH5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
View Old Accession Versions >>
OHu22064	NM_139318.4	Homo sapiens potassium voltage-gated channel subfamily H member 5 (KCNH5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
OHu13011	NM_172375.2	Homo sapiens potassium voltage-gated channel subfamily H member 5 (KCNH5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNH5 ( NM_172375.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_758963.1 Homo sapiens potassium voltage-gated channel subfamily H member 5 (KCNH5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu13011
Clone ID Related Accession (Same CDS sequence)	NM_172375.2 , NM_172375.3
Accession Version	NM_172375.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1836bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily H member 5 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL132666.8, AF493798.1 and AL355101.2. On Jul 16, 2013 this sequence version replaced NM_172375.1. Transcript Variant: This variant (3), also known as HEAG2b, lacks an exon in the coding region, which results in a frameshift and an early stop codon, as compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF493798.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGGGG GCAAGAGAGG GCTGGTGGCA CCGCAGAACA CATTTTTGGA GAACATCGTC 
AGGCGCTCCA GTGAATCAAG TTTCTTACTG GGAAATGCCC AGATTGTGGA TTGGCCTGTA 
GTTTATAGTA ATGACGGTTT TTGTAAACTC TCTGGATATC ATCGAGCTGA CGTCATGCAG 
AAAAGCAGCA CTTGCAGTTT TATGTATGGG GAATTGACTG ACAAGAAGAC CATTGAGAAA 
GTCAGGCAAA CTTTTGACAA CTACGAATCA AACTGCTTTG AAGTTCTTCT GTACAAGAAA 
AACAGAACCC CTGTTTGGTT TTATATGCAA ATTGCACCAA TAAGAAATGA ACATGAAAAG 
GTGGTCTTGT TCCTGTGTAC TTTCAAGGAT ATTACGTTGT TCAAACAGCC AATAGAGGAT 
GATTCAACAA AAGGTTGGAC GAAATTTGCC CGATTGACAC GGGCTTTGAC AAATAGCCGA 
AGTGTTTTGC AGCAGCTCAC GCCAATGAAT AAAACAGAGG TGGTCCATAA ACATTCAAGA 
CTAGCTGAAG TTCTTCAGCT GGGATCAGAT ATCCTTCCTC AGTATAAACA AGAAGCGCCA 
AAGACGCCAC CACACATTAT TTTACATTAT TGTGCTTTTA AAACTACTTG GGATTGGGTG 
ATTTTAATTC TTACCTTCTA CACCGCCATT ATGGTTCCTT ATAATGTTTC CTTCAAAACA 
AAGCAGAACA ACATAGCCTG GCTGGTACTG GATAGTGTGG TGGACGTTAT TTTTCTGGTT 
GACATCGTTT TAAATTTTCA CACGACTTTC GTGGGGCCCG GTGGAGAGGT CATTTCTGAC 
CCTAAGCTCA TAAGGATGAA CTATCTGAAA ACTTGGTTTG TGATCGATCT GCTGTCTTGT 
TTACCTTATG ACATCATCAA TGCCTTTGAA AATGTGGATG AGGGAATCAG CAGTCTCTTC 
AGTTCTTTAA AAGTGGTGCG TCTCTTACGA CTGGGCCGTG TGGCTAGGAA ACTGGACCAT 
TACCTAGAAT ATGGAGCAGC AGTCCTCGTG CTCCTGGTGT GTGTGTTTGG ACTGGTGGCC 
CACTGGCTGG CCTGCATATG GTATAGCATC GGAGACTACG AGGTCATTGA TGAAGTCACT 
AACACCATCC AAATAGACAG TTGGCTCTAC CAGCTGGCTT TGAGCATTGG GACTCCATAT 
CGCTACAATA CCAGTGCTGG GATATGGGAA GGAGGACCCA GCAAGGATTC ATTGTACGTG 
TCCTCTCTCT ACTTTACCAT GACAAGCCTT ACAACCATAG GATTTGGAAA CATAGCTCCT 
ACCACAGATG TGGAGAAGAT GTTTTCGGTG GCTATGATGA TGGTTGGCTC TCTTCTTTAT 
GCAACTATTT TTGGAAATGT TACAACAATT TTCCAGCAAA TGTATGCCAA CACCAACCGA 
TACCATGAGA TGCTGAATAA TGTACGGGAC TTCCTAAAAC TCTATCAGGT CCCAAAAGGC 
CTTAGTGAGC GAGTCATGGA TTATATTGTC TCAACATGGT CCATGTCAAA AGGCATTGAT 
ACAGAAAAGG TCCTCTCCAT CTGTCCCAAG GACATGAGAG CTGATATCTG TGTTCATCTA 
AACCGGAAGG TTTTTAATGA ACATCCTGCT TTTCGATTGG CCAGCGATGG GTGTCTGCGC 
GCCTTGGCGG TAGAGTTCCA AACCATTCAC TGTGCTCCCG GGGACCTCAT TTACCATGCT 
GGAGAAAGTG TGGATGCCCT CTGCTTTGTG GTGTCAGGAT CCTTGGAAGT CATCCAGGAT 
GATGAGGTGG TGGCTATTTT AGATCATCTT TCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758963.1
CDS	53..1888
Translation	MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILDHLS

Target ORF information:

RefSeq Version	NM_172375.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily H member 5 (KCNH5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172375.2

ORF Insert Sequence:

ATGCCGGGGG GCAAGAGAGG GCTGGTGGCA CCGCAGAACA CATTTTTGGA GAACATCGTC 
AGGCGCTCCA GTGAATCAAG TTTCTTACTG GGAAATGCCC AGATTGTGGA TTGGCCTGTA 
GTTTATAGTA ATGACGGTTT TTGTAAACTC TCTGGATATC ATCGAGCTGA CGTCATGCAG 
AAAAGCAGCA CTTGCAGTTT TATGTATGGG GAATTGACTG ACAAGAAGAC CATTGAGAAA 
GTCAGGCAAA CTTTTGACAA CTACGAATCA AACTGCTTTG AAGTTCTTCT GTACAAGAAA 
AACAGAACCC CTGTTTGGTT TTATATGCAA ATTGCACCAA TAAGAAATGA ACATGAAAAG 
GTGGTCTTGT TCCTGTGTAC TTTCAAGGAT ATTACGTTGT TCAAACAGCC AATAGAGGAT 
GATTCAACAA AAGGTTGGAC GAAATTTGCC CGATTGACAC GGGCTTTGAC AAATAGCCGA 
AGTGTTTTGC AGCAGCTCAC GCCAATGAAT AAAACAGAGG TGGTCCATAA ACATTCAAGA 
CTAGCTGAAG TTCTTCAGCT GGGATCAGAT ATCCTTCCTC AGTATAAACA AGAAGCGCCA 
AAGACGCCAC CACACATTAT TTTACATTAT TGTGCTTTTA AAACTACTTG GGATTGGGTG 
ATTTTAATTC TTACCTTCTA CACCGCCATT ATGGTTCCTT ATAATGTTTC CTTCAAAACA 
AAGCAGAACA ACATAGCCTG GCTGGTACTG GATAGTGTGG TGGACGTTAT TTTTCTGGTT 
GACATCGTTT TAAATTTTCA CACGACTTTC GTGGGGCCCG GTGGAGAGGT CATTTCTGAC 
CCTAAGCTCA TAAGGATGAA CTATCTGAAA ACTTGGTTTG TGATCGATCT GCTGTCTTGT 
TTACCTTATG ACATCATCAA TGCCTTTGAA AATGTGGATG AGGGAATCAG CAGTCTCTTC 
AGTTCTTTAA AAGTGGTGCG TCTCTTACGA CTGGGCCGTG TGGCTAGGAA ACTGGACCAT 
TACCTAGAAT ATGGAGCAGC AGTCCTCGTG CTCCTGGTGT GTGTGTTTGG ACTGGTGGCC 
CACTGGCTGG CCTGCATATG GTATAGCATC GGAGACTACG AGGTCATTGA TGAAGTCACT 
AACACCATCC AAATAGACAG TTGGCTCTAC CAGCTGGCTT TGAGCATTGG GACTCCATAT 
CGCTACAATA CCAGTGCTGG GATATGGGAA GGAGGACCCA GCAAGGATTC ATTGTACGTG 
TCCTCTCTCT ACTTTACCAT GACAAGCCTT ACAACCATAG GATTTGGAAA CATAGCTCCT 
ACCACAGATG TGGAGAAGAT GTTTTCGGTG GCTATGATGA TGGTTGGCTC TCTTCTTTAT 
GCAACTATTT TTGGAAATGT TACAACAATT TTCCAGCAAA TGTATGCCAA CACCAACCGA 
TACCATGAGA TGCTGAATAA TGTACGGGAC TTCCTAAAAC TCTATCAGGT CCCAAAAGGC 
CTTAGTGAGC GAGTCATGGA TTATATTGTC TCAACATGGT CCATGTCAAA AGGCATTGAT 
ACAGAAAAGG TCCTCTCCAT CTGTCCCAAG GACATGAGAG CTGATATCTG TGTTCATCTA 
AACCGGAAGG TTTTTAATGA ACATCCTGCT TTTCGATTGG CCAGCGATGG GTGTCTGCGC 
GCCTTGGCGG TAGAGTTCCA AACCATTCAC TGTGCTCCCG GGGACCTCAT TTACCATGCT 
GGAGAAAGTG TGGATGCCCT CTGCTTTGTG GTGTCAGGAT CCTTGGAAGT CATCCAGGAT 
GATGAGGTGG TGGCTATTTT AGATCATCTT TCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNH5 ( NM_172375.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_758963.1 Homo sapiens potassium voltage-gated channel subfamily H member 5 (KCNH5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu13011
Clone ID Related Accession (Same CDS sequence)	NM_172375.2 , NM_172375.3
Accession Version	NM_172375.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1836bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-27
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily H member 5 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL132666.8, AF493798.1 and AL355101.2. On May 31, 2019 this sequence version replaced NM_172375.2. Transcript Variant: This variant (3), also known as HEAG2b, lacks an exon in the coding region, which results in a frameshift and an early stop codon, as compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF493798.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGGGG GCAAGAGAGG GCTGGTGGCA CCGCAGAACA CATTTTTGGA GAACATCGTC 
AGGCGCTCCA GTGAATCAAG TTTCTTACTG GGAAATGCCC AGATTGTGGA TTGGCCTGTA 
GTTTATAGTA ATGACGGTTT TTGTAAACTC TCTGGATATC ATCGAGCTGA CGTCATGCAG 
AAAAGCAGCA CTTGCAGTTT TATGTATGGG GAATTGACTG ACAAGAAGAC CATTGAGAAA 
GTCAGGCAAA CTTTTGACAA CTACGAATCA AACTGCTTTG AAGTTCTTCT GTACAAGAAA 
AACAGAACCC CTGTTTGGTT TTATATGCAA ATTGCACCAA TAAGAAATGA ACATGAAAAG 
GTGGTCTTGT TCCTGTGTAC TTTCAAGGAT ATTACGTTGT TCAAACAGCC AATAGAGGAT 
GATTCAACAA AAGGTTGGAC GAAATTTGCC CGATTGACAC GGGCTTTGAC AAATAGCCGA 
AGTGTTTTGC AGCAGCTCAC GCCAATGAAT AAAACAGAGG TGGTCCATAA ACATTCAAGA 
CTAGCTGAAG TTCTTCAGCT GGGATCAGAT ATCCTTCCTC AGTATAAACA AGAAGCGCCA 
AAGACGCCAC CACACATTAT TTTACATTAT TGTGCTTTTA AAACTACTTG GGATTGGGTG 
ATTTTAATTC TTACCTTCTA CACCGCCATT ATGGTTCCTT ATAATGTTTC CTTCAAAACA 
AAGCAGAACA ACATAGCCTG GCTGGTACTG GATAGTGTGG TGGACGTTAT TTTTCTGGTT 
GACATCGTTT TAAATTTTCA CACGACTTTC GTGGGGCCCG GTGGAGAGGT CATTTCTGAC 
CCTAAGCTCA TAAGGATGAA CTATCTGAAA ACTTGGTTTG TGATCGATCT GCTGTCTTGT 
TTACCTTATG ACATCATCAA TGCCTTTGAA AATGTGGATG AGGGAATCAG CAGTCTCTTC 
AGTTCTTTAA AAGTGGTGCG TCTCTTACGA CTGGGCCGTG TGGCTAGGAA ACTGGACCAT 
TACCTAGAAT ATGGAGCAGC AGTCCTCGTG CTCCTGGTGT GTGTGTTTGG ACTGGTGGCC 
CACTGGCTGG CCTGCATATG GTATAGCATC GGAGACTACG AGGTCATTGA TGAAGTCACT 
AACACCATCC AAATAGACAG TTGGCTCTAC CAGCTGGCTT TGAGCATTGG GACTCCATAT 
CGCTACAATA CCAGTGCTGG GATATGGGAA GGAGGACCCA GCAAGGATTC ATTGTACGTG 
TCCTCTCTCT ACTTTACCAT GACAAGCCTT ACAACCATAG GATTTGGAAA CATAGCTCCT 
ACCACAGATG TGGAGAAGAT GTTTTCGGTG GCTATGATGA TGGTTGGCTC TCTTCTTTAT 
GCAACTATTT TTGGAAATGT TACAACAATT TTCCAGCAAA TGTATGCCAA CACCAACCGA 
TACCATGAGA TGCTGAATAA TGTACGGGAC TTCCTAAAAC TCTATCAGGT CCCAAAAGGC 
CTTAGTGAGC GAGTCATGGA TTATATTGTC TCAACATGGT CCATGTCAAA AGGCATTGAT 
ACAGAAAAGG TCCTCTCCAT CTGTCCCAAG GACATGAGAG CTGATATCTG TGTTCATCTA 
AACCGGAAGG TTTTTAATGA ACATCCTGCT TTTCGATTGG CCAGCGATGG GTGTCTGCGC 
GCCTTGGCGG TAGAGTTCCA AACCATTCAC TGTGCTCCCG GGGACCTCAT TTACCATGCT 
GGAGAAAGTG TGGATGCCCT CTGCTTTGTG GTGTCAGGAT CCTTGGAAGT CATCCAGGAT 
GATGAGGTGG TGGCTATTTT AGATCATCTT TCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758963.1
CDS	273..2108
Translation	MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILDHLS

Target ORF information:

RefSeq Version	NM_172375.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily H member 5 (KCNH5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172375.3

ORF Insert Sequence:

ATGCCGGGGG GCAAGAGAGG GCTGGTGGCA CCGCAGAACA CATTTTTGGA GAACATCGTC 
AGGCGCTCCA GTGAATCAAG TTTCTTACTG GGAAATGCCC AGATTGTGGA TTGGCCTGTA 
GTTTATAGTA ATGACGGTTT TTGTAAACTC TCTGGATATC ATCGAGCTGA CGTCATGCAG 
AAAAGCAGCA CTTGCAGTTT TATGTATGGG GAATTGACTG ACAAGAAGAC CATTGAGAAA 
GTCAGGCAAA CTTTTGACAA CTACGAATCA AACTGCTTTG AAGTTCTTCT GTACAAGAAA 
AACAGAACCC CTGTTTGGTT TTATATGCAA ATTGCACCAA TAAGAAATGA ACATGAAAAG 
GTGGTCTTGT TCCTGTGTAC TTTCAAGGAT ATTACGTTGT TCAAACAGCC AATAGAGGAT 
GATTCAACAA AAGGTTGGAC GAAATTTGCC CGATTGACAC GGGCTTTGAC AAATAGCCGA 
AGTGTTTTGC AGCAGCTCAC GCCAATGAAT AAAACAGAGG TGGTCCATAA ACATTCAAGA 
CTAGCTGAAG TTCTTCAGCT GGGATCAGAT ATCCTTCCTC AGTATAAACA AGAAGCGCCA 
AAGACGCCAC CACACATTAT TTTACATTAT TGTGCTTTTA AAACTACTTG GGATTGGGTG 
ATTTTAATTC TTACCTTCTA CACCGCCATT ATGGTTCCTT ATAATGTTTC CTTCAAAACA 
AAGCAGAACA ACATAGCCTG GCTGGTACTG GATAGTGTGG TGGACGTTAT TTTTCTGGTT 
GACATCGTTT TAAATTTTCA CACGACTTTC GTGGGGCCCG GTGGAGAGGT CATTTCTGAC 
CCTAAGCTCA TAAGGATGAA CTATCTGAAA ACTTGGTTTG TGATCGATCT GCTGTCTTGT 
TTACCTTATG ACATCATCAA TGCCTTTGAA AATGTGGATG AGGGAATCAG CAGTCTCTTC 
AGTTCTTTAA AAGTGGTGCG TCTCTTACGA CTGGGCCGTG TGGCTAGGAA ACTGGACCAT 
TACCTAGAAT ATGGAGCAGC AGTCCTCGTG CTCCTGGTGT GTGTGTTTGG ACTGGTGGCC 
CACTGGCTGG CCTGCATATG GTATAGCATC GGAGACTACG AGGTCATTGA TGAAGTCACT 
AACACCATCC AAATAGACAG TTGGCTCTAC CAGCTGGCTT TGAGCATTGG GACTCCATAT 
CGCTACAATA CCAGTGCTGG GATATGGGAA GGAGGACCCA GCAAGGATTC ATTGTACGTG 
TCCTCTCTCT ACTTTACCAT GACAAGCCTT ACAACCATAG GATTTGGAAA CATAGCTCCT 
ACCACAGATG TGGAGAAGAT GTTTTCGGTG GCTATGATGA TGGTTGGCTC TCTTCTTTAT 
GCAACTATTT TTGGAAATGT TACAACAATT TTCCAGCAAA TGTATGCCAA CACCAACCGA 
TACCATGAGA TGCTGAATAA TGTACGGGAC TTCCTAAAAC TCTATCAGGT CCCAAAAGGC 
CTTAGTGAGC GAGTCATGGA TTATATTGTC TCAACATGGT CCATGTCAAA AGGCATTGAT 
ACAGAAAAGG TCCTCTCCAT CTGTCCCAAG GACATGAGAG CTGATATCTG TGTTCATCTA 
AACCGGAAGG TTTTTAATGA ACATCCTGCT TTTCGATTGG CCAGCGATGG GTGTCTGCGC 
GCCTTGGCGG TAGAGTTCCA AACCATTCAC TGTGCTCCCG GGGACCTCAT TTACCATGCT 
GGAGAAAGTG TGGATGCCCT CTGCTTTGTG GTGTCAGGAT CCTTGGAAGT CATCCAGGAT 
GATGAGGTGG TGGCTATTTT AGATCATCTT TCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNH5 ( NM_139318.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_647479.2 Homo sapiens potassium voltage-gated channel subfamily H member 5 (KCNH5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22064
Clone ID Related Accession (Same CDS sequence)	NM_139318.5 , NM_139318.4
Accession Version	NM_139318.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2967bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-27
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily H member 5 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL132666.8, BC073979.1, AF472412.1 and AL355101.2. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_139318.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC073979.1, SRR1660805.169557.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000322893.12/ ENSP00000321427.7 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGGGGG GCAAGAGAGG GCTGGTGGCA CCGCAGAACA CATTTTTGGA GAACATCGTC 
AGGCGCTCCA GTGAATCAAG TTTCTTACTG GGAAATGCCC AGATTGTGGA TTGGCCTGTA 
GTTTATAGTA ATGACGGTTT TTGTAAACTC TCTGGATATC ATCGAGCTGA CGTCATGCAG 
AAAAGCAGCA CTTGCAGTTT TATGTATGGG GAATTGACTG ACAAGAAGAC CATTGAGAAA 
GTCAGGCAAA CTTTTGACAA CTACGAATCA AACTGCTTTG AAGTTCTTCT GTACAAGAAA 
AACAGAACCC CTGTTTGGTT TTATATGCAA ATTGCACCAA TAAGAAATGA ACATGAAAAG 
GTGGTCTTGT TCCTGTGTAC TTTCAAGGAT ATTACGTTGT TCAAACAGCC AATAGAGGAT 
GATTCAACAA AAGGTTGGAC GAAATTTGCC CGATTGACAC GGGCTTTGAC AAATAGCCGA 
AGTGTTTTGC AGCAGCTCAC GCCAATGAAT AAAACAGAGG TGGTCCATAA ACATTCAAGA 
CTAGCTGAAG TTCTTCAGCT GGGATCAGAT ATCCTTCCTC AGTATAAACA AGAAGCGCCA 
AAGACGCCAC CACACATTAT TTTACATTAT TGTGCTTTTA AAACTACTTG GGATTGGGTG 
ATTTTAATTC TTACCTTCTA CACCGCCATT ATGGTTCCTT ATAATGTTTC CTTCAAAACA 
AAGCAGAACA ACATAGCCTG GCTGGTACTG GATAGTGTGG TGGACGTTAT TTTTCTGGTT 
GACATCGTTT TAAATTTTCA CACGACTTTC GTGGGGCCCG GTGGAGAGGT CATTTCTGAC 
CCTAAGCTCA TAAGGATGAA CTATCTGAAA ACTTGGTTTG TGATCGATCT GCTGTCTTGT 
TTACCTTATG ACATCATCAA TGCCTTTGAA AATGTGGATG AGGGAATCAG CAGTCTCTTC 
AGTTCTTTAA AAGTGGTGCG TCTCTTACGA CTGGGCCGTG TGGCTAGGAA ACTGGACCAT 
TACCTAGAAT ATGGAGCAGC AGTCCTCGTG CTCCTGGTGT GTGTGTTTGG ACTGGTGGCC 
CACTGGCTGG CCTGCATATG GTATAGCATC GGAGACTACG AGGTCATTGA TGAAGTCACT 
AACACCATCC AAATAGACAG TTGGCTCTAC CAGCTGGCTT TGAGCATTGG GACTCCATAT 
CGCTACAATA CCAGTGCTGG GATATGGGAA GGAGGACCCA GCAAGGATTC ATTGTACGTG 
TCCTCTCTCT ACTTTACCAT GACAAGCCTT ACAACCATAG GATTTGGAAA CATAGCTCCT 
ACCACAGATG TGGAGAAGAT GTTTTCGGTG GCTATGATGA TGGTTGGCTC TCTTCTTTAT 
GCAACTATTT TTGGAAATGT TACAACAATT TTCCAGCAAA TGTATGCCAA CACCAACCGA 
TACCATGAGA TGCTGAATAA TGTACGGGAC TTCCTAAAAC TCTATCAGGT CCCAAAAGGC 
CTTAGTGAGC GAGTCATGGA TTATATTGTC TCAACATGGT CCATGTCAAA AGGCATTGAT 
ACAGAAAAGG TCCTCTCCAT CTGTCCCAAG GACATGAGAG CTGATATCTG TGTTCATCTA 
AACCGGAAGG TTTTTAATGA ACATCCTGCT TTTCGATTGG CCAGCGATGG GTGTCTGCGC 
GCCTTGGCGG TAGAGTTCCA AACCATTCAC TGTGCTCCCG GGGACCTCAT TTACCATGCT 
GGAGAAAGTG TGGATGCCCT CTGCTTTGTG GTGTCAGGAT CCTTGGAAGT CATCCAGGAT 
GATGAGGTGG TGGCTATTTT AGGGAAGGGT GATGTATTTG GAGACATCTT CTGGAAGGAA 
ACCACCCTTG CCCATGCATG TGCGAACGTC CGGGCACTGA CGTACTGTGA CCTACACATC 
ATCAAGCGGG AAGCCTTGCT CAAAGTCCTG GACTTTTATA CAGCTTTTGC AAACTCCTTC 
TCAAGGAATC TCACTCTTAC TTGCAATCTG AGGAAACGGA TCATCTTTCG TAAGATCAGT 
GATGTGAAGA AAGAGGAGGA GGAGCGCCTC CGGCAGAAGA ATGAGGTGAC CCTCAGCATT 
CCCGTGGACC ACCCAGTCAG AAAGCTCTTC CAGAAGTTCA AGCAGCAGAA GGAGCTGCGG 
AATCAGGGCT CAACACAGGG TGACCCTGAG AGGAACCAAC TCCAGGTAGA GAGCCGCTCC 
TTACAGAATG GAGCCTCCAT CACCGGAACC AGCGTGGTGA CTGTGTCACA GATTACTCCC 
ATTCAGACGT CTCTGGCCTA TGTGAAAACC AGTGAATCCC TTAAGCAGAA CAACCGTGAT 
GCCATGGAAC TCAAGCCCAA CGGCGGTGCT GACCAAAAAT GTCTCAAAGT CAACAGCCCA 
ATAAGAATGA AGAATGGAAA TGGAAAAGGG TGGCTGCGAC TCAAGAATAA TATGGGAGCC 
CATGAGGAGA AAAAGGAAGA CTGGAATAAT GTCACTAAAG CTGAGTCAAT GGGGCTATTG 
TCTGAGGACC CCAAGAGCAG TGATTCAGAG AACAGTGTGA CCAAAAACCC ACTAAGAAAA 
ACAGATTCTT GTGACAGTGG AATTACAAAA AGTGACCTTC GTTTGGATAA GGCTGGGGAG 
GCCCGAAGTC CGCTAGAGCA CAGTCCCATC CAGGCTGATG CCAAGCACCC CTTTTATCCC 
ATCCCCGAGC AGGCCTTACA GACCACACTG CAGGAAGTCA AACACGAACT CAAAGAGGAC 
ATCCAGCTGC TCAGCTGCAG AATGACTGCC CTAGAAAAGC AGGTGGCAGA AATTTTAAAA 
ATACTGTCGG AAAAAAGCGT ACCCCAGGCC TCATCTCCCA AATCCCAAAT GCCACTCCAA 
GTACCCCCCC AGATACCATG TCAGGATATT TTTAGTGTCT CAAGGCCTGA ATCACCTGAA 
TCTGACAAAG ATGAAATCCA CTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_647479.2
CDS	273..3239
Translation	MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQGDPERNQLQVESRSLQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLLSEDPKSSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQVPPQIPCQDIFSVSRPESPESDKDEIHF

Target ORF information:

RefSeq Version	NM_139318.5
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily H member 5 (KCNH5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139318.5

ORF Insert Sequence:

ATGCCGGGGG GCAAGAGAGG GCTGGTGGCA CCGCAGAACA CATTTTTGGA GAACATCGTC 
AGGCGCTCCA GTGAATCAAG TTTCTTACTG GGAAATGCCC AGATTGTGGA TTGGCCTGTA 
GTTTATAGTA ATGACGGTTT TTGTAAACTC TCTGGATATC ATCGAGCTGA CGTCATGCAG 
AAAAGCAGCA CTTGCAGTTT TATGTATGGG GAATTGACTG ACAAGAAGAC CATTGAGAAA 
GTCAGGCAAA CTTTTGACAA CTACGAATCA AACTGCTTTG AAGTTCTTCT GTACAAGAAA 
AACAGAACCC CTGTTTGGTT TTATATGCAA ATTGCACCAA TAAGAAATGA ACATGAAAAG 
GTGGTCTTGT TCCTGTGTAC TTTCAAGGAT ATTACGTTGT TCAAACAGCC AATAGAGGAT 
GATTCAACAA AAGGTTGGAC GAAATTTGCC CGATTGACAC GGGCTTTGAC AAATAGCCGA 
AGTGTTTTGC AGCAGCTCAC GCCAATGAAT AAAACAGAGG TGGTCCATAA ACATTCAAGA 
CTAGCTGAAG TTCTTCAGCT GGGATCAGAT ATCCTTCCTC AGTATAAACA AGAAGCGCCA 
AAGACGCCAC CACACATTAT TTTACATTAT TGTGCTTTTA AAACTACTTG GGATTGGGTG 
ATTTTAATTC TTACCTTCTA CACCGCCATT ATGGTTCCTT ATAATGTTTC CTTCAAAACA 
AAGCAGAACA ACATAGCCTG GCTGGTACTG GATAGTGTGG TGGACGTTAT TTTTCTGGTT 
GACATCGTTT TAAATTTTCA CACGACTTTC GTGGGGCCCG GTGGAGAGGT CATTTCTGAC 
CCTAAGCTCA TAAGGATGAA CTATCTGAAA ACTTGGTTTG TGATCGATCT GCTGTCTTGT 
TTACCTTATG ACATCATCAA TGCCTTTGAA AATGTGGATG AGGGAATCAG CAGTCTCTTC 
AGTTCTTTAA AAGTGGTGCG TCTCTTACGA CTGGGCCGTG TGGCTAGGAA ACTGGACCAT 
TACCTAGAAT ATGGAGCAGC AGTCCTCGTG CTCCTGGTGT GTGTGTTTGG ACTGGTGGCC 
CACTGGCTGG CCTGCATATG GTATAGCATC GGAGACTACG AGGTCATTGA TGAAGTCACT 
AACACCATCC AAATAGACAG TTGGCTCTAC CAGCTGGCTT TGAGCATTGG GACTCCATAT 
CGCTACAATA CCAGTGCTGG GATATGGGAA GGAGGACCCA GCAAGGATTC ATTGTACGTG 
TCCTCTCTCT ACTTTACCAT GACAAGCCTT ACAACCATAG GATTTGGAAA CATAGCTCCT 
ACCACAGATG TGGAGAAGAT GTTTTCGGTG GCTATGATGA TGGTTGGCTC TCTTCTTTAT 
GCAACTATTT TTGGAAATGT TACAACAATT TTCCAGCAAA TGTATGCCAA CACCAACCGA 
TACCATGAGA TGCTGAATAA TGTACGGGAC TTCCTAAAAC TCTATCAGGT CCCAAAAGGC 
CTTAGTGAGC GAGTCATGGA TTATATTGTC TCAACATGGT CCATGTCAAA AGGCATTGAT 
ACAGAAAAGG TCCTCTCCAT CTGTCCCAAG GACATGAGAG CTGATATCTG TGTTCATCTA 
AACCGGAAGG TTTTTAATGA ACATCCTGCT TTTCGATTGG CCAGCGATGG GTGTCTGCGC 
GCCTTGGCGG TAGAGTTCCA AACCATTCAC TGTGCTCCCG GGGACCTCAT TTACCATGCT 
GGAGAAAGTG TGGATGCCCT CTGCTTTGTG GTGTCAGGAT CCTTGGAAGT CATCCAGGAT 
GATGAGGTGG TGGCTATTTT AGGGAAGGGT GATGTATTTG GAGACATCTT CTGGAAGGAA 
ACCACCCTTG CCCATGCATG TGCGAACGTC CGGGCACTGA CGTACTGTGA CCTACACATC 
ATCAAGCGGG AAGCCTTGCT CAAAGTCCTG GACTTTTATA CAGCTTTTGC AAACTCCTTC 
TCAAGGAATC TCACTCTTAC TTGCAATCTG AGGAAACGGA TCATCTTTCG TAAGATCAGT 
GATGTGAAGA AAGAGGAGGA GGAGCGCCTC CGGCAGAAGA ATGAGGTGAC CCTCAGCATT 
CCCGTGGACC ACCCAGTCAG AAAGCTCTTC CAGAAGTTCA AGCAGCAGAA GGAGCTGCGG 
AATCAGGGCT CAACACAGGG TGACCCTGAG AGGAACCAAC TCCAGGTAGA GAGCCGCTCC 
TTACAGAATG GAGCCTCCAT CACCGGAACC AGCGTGGTGA CTGTGTCACA GATTACTCCC 
ATTCAGACGT CTCTGGCCTA TGTGAAAACC AGTGAATCCC TTAAGCAGAA CAACCGTGAT 
GCCATGGAAC TCAAGCCCAA CGGCGGTGCT GACCAAAAAT GTCTCAAAGT CAACAGCCCA 
ATAAGAATGA AGAATGGAAA TGGAAAAGGG TGGCTGCGAC TCAAGAATAA TATGGGAGCC 
CATGAGGAGA AAAAGGAAGA CTGGAATAAT GTCACTAAAG CTGAGTCAAT GGGGCTATTG 
TCTGAGGACC CCAAGAGCAG TGATTCAGAG AACAGTGTGA CCAAAAACCC ACTAAGAAAA 
ACAGATTCTT GTGACAGTGG AATTACAAAA AGTGACCTTC GTTTGGATAA GGCTGGGGAG 
GCCCGAAGTC CGCTAGAGCA CAGTCCCATC CAGGCTGATG CCAAGCACCC CTTTTATCCC 
ATCCCCGAGC AGGCCTTACA GACCACACTG CAGGAAGTCA AACACGAACT CAAAGAGGAC 
ATCCAGCTGC TCAGCTGCAG AATGACTGCC CTAGAAAAGC AGGTGGCAGA AATTTTAAAA 
ATACTGTCGG AAAAAAGCGT ACCCCAGGCC TCATCTCCCA AATCCCAAAT GCCACTCCAA 
GTACCCCCCC AGATACCATG TCAGGATATT TTTAGTGTCT CAAGGCCTGA ATCACCTGAA 
TCTGACAAAG ATGAAATCCA CTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNH5 ( NM_139318.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_647479.2 Homo sapiens potassium voltage-gated channel subfamily H member 5 (KCNH5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22064
Clone ID Related Accession (Same CDS sequence)	NM_139318.5 , NM_139318.4
Accession Version	NM_139318.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2967bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily H member 5 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC073979.1, AF472412.1 and AL355101.2. This sequence is a reference standard in the RefSeqGene project. On Jul 16, 2013 this sequence version replaced NM_139318.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC073979.1, SRR1660805.169557.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGGGG GCAAGAGAGG GCTGGTGGCA CCGCAGAACA CATTTTTGGA GAACATCGTC 
AGGCGCTCCA GTGAATCAAG TTTCTTACTG GGAAATGCCC AGATTGTGGA TTGGCCTGTA 
GTTTATAGTA ATGACGGTTT TTGTAAACTC TCTGGATATC ATCGAGCTGA CGTCATGCAG 
AAAAGCAGCA CTTGCAGTTT TATGTATGGG GAATTGACTG ACAAGAAGAC CATTGAGAAA 
GTCAGGCAAA CTTTTGACAA CTACGAATCA AACTGCTTTG AAGTTCTTCT GTACAAGAAA 
AACAGAACCC CTGTTTGGTT TTATATGCAA ATTGCACCAA TAAGAAATGA ACATGAAAAG 
GTGGTCTTGT TCCTGTGTAC TTTCAAGGAT ATTACGTTGT TCAAACAGCC AATAGAGGAT 
GATTCAACAA AAGGTTGGAC GAAATTTGCC CGATTGACAC GGGCTTTGAC AAATAGCCGA 
AGTGTTTTGC AGCAGCTCAC GCCAATGAAT AAAACAGAGG TGGTCCATAA ACATTCAAGA 
CTAGCTGAAG TTCTTCAGCT GGGATCAGAT ATCCTTCCTC AGTATAAACA AGAAGCGCCA 
AAGACGCCAC CACACATTAT TTTACATTAT TGTGCTTTTA AAACTACTTG GGATTGGGTG 
ATTTTAATTC TTACCTTCTA CACCGCCATT ATGGTTCCTT ATAATGTTTC CTTCAAAACA 
AAGCAGAACA ACATAGCCTG GCTGGTACTG GATAGTGTGG TGGACGTTAT TTTTCTGGTT 
GACATCGTTT TAAATTTTCA CACGACTTTC GTGGGGCCCG GTGGAGAGGT CATTTCTGAC 
CCTAAGCTCA TAAGGATGAA CTATCTGAAA ACTTGGTTTG TGATCGATCT GCTGTCTTGT 
TTACCTTATG ACATCATCAA TGCCTTTGAA AATGTGGATG AGGGAATCAG CAGTCTCTTC 
AGTTCTTTAA AAGTGGTGCG TCTCTTACGA CTGGGCCGTG TGGCTAGGAA ACTGGACCAT 
TACCTAGAAT ATGGAGCAGC AGTCCTCGTG CTCCTGGTGT GTGTGTTTGG ACTGGTGGCC 
CACTGGCTGG CCTGCATATG GTATAGCATC GGAGACTACG AGGTCATTGA TGAAGTCACT 
AACACCATCC AAATAGACAG TTGGCTCTAC CAGCTGGCTT TGAGCATTGG GACTCCATAT 
CGCTACAATA CCAGTGCTGG GATATGGGAA GGAGGACCCA GCAAGGATTC ATTGTACGTG 
TCCTCTCTCT ACTTTACCAT GACAAGCCTT ACAACCATAG GATTTGGAAA CATAGCTCCT 
ACCACAGATG TGGAGAAGAT GTTTTCGGTG GCTATGATGA TGGTTGGCTC TCTTCTTTAT 
GCAACTATTT TTGGAAATGT TACAACAATT TTCCAGCAAA TGTATGCCAA CACCAACCGA 
TACCATGAGA TGCTGAATAA TGTACGGGAC TTCCTAAAAC TCTATCAGGT CCCAAAAGGC 
CTTAGTGAGC GAGTCATGGA TTATATTGTC TCAACATGGT CCATGTCAAA AGGCATTGAT 
ACAGAAAAGG TCCTCTCCAT CTGTCCCAAG GACATGAGAG CTGATATCTG TGTTCATCTA 
AACCGGAAGG TTTTTAATGA ACATCCTGCT TTTCGATTGG CCAGCGATGG GTGTCTGCGC 
GCCTTGGCGG TAGAGTTCCA AACCATTCAC TGTGCTCCCG GGGACCTCAT TTACCATGCT 
GGAGAAAGTG TGGATGCCCT CTGCTTTGTG GTGTCAGGAT CCTTGGAAGT CATCCAGGAT 
GATGAGGTGG TGGCTATTTT AGGGAAGGGT GATGTATTTG GAGACATCTT CTGGAAGGAA 
ACCACCCTTG CCCATGCATG TGCGAACGTC CGGGCACTGA CGTACTGTGA CCTACACATC 
ATCAAGCGGG AAGCCTTGCT CAAAGTCCTG GACTTTTATA CAGCTTTTGC AAACTCCTTC 
TCAAGGAATC TCACTCTTAC TTGCAATCTG AGGAAACGGA TCATCTTTCG TAAGATCAGT 
GATGTGAAGA AAGAGGAGGA GGAGCGCCTC CGGCAGAAGA ATGAGGTGAC CCTCAGCATT 
CCCGTGGACC ACCCAGTCAG AAAGCTCTTC CAGAAGTTCA AGCAGCAGAA GGAGCTGCGG 
AATCAGGGCT CAACACAGGG TGACCCTGAG AGGAACCAAC TCCAGGTAGA GAGCCGCTCC 
TTACAGAATG GAGCCTCCAT CACCGGAACC AGCGTGGTGA CTGTGTCACA GATTACTCCC 
ATTCAGACGT CTCTGGCCTA TGTGAAAACC AGTGAATCCC TTAAGCAGAA CAACCGTGAT 
GCCATGGAAC TCAAGCCCAA CGGCGGTGCT GACCAAAAAT GTCTCAAAGT CAACAGCCCA 
ATAAGAATGA AGAATGGAAA TGGAAAAGGG TGGCTGCGAC TCAAGAATAA TATGGGAGCC 
CATGAGGAGA AAAAGGAAGA CTGGAATAAT GTCACTAAAG CTGAGTCAAT GGGGCTATTG 
TCTGAGGACC CCAAGAGCAG TGATTCAGAG AACAGTGTGA CCAAAAACCC ACTAAGAAAA 
ACAGATTCTT GTGACAGTGG AATTACAAAA AGTGACCTTC GTTTGGATAA GGCTGGGGAG 
GCCCGAAGTC CGCTAGAGCA CAGTCCCATC CAGGCTGATG CCAAGCACCC CTTTTATCCC 
ATCCCCGAGC AGGCCTTACA GACCACACTG CAGGAAGTCA AACACGAACT CAAAGAGGAC 
ATCCAGCTGC TCAGCTGCAG AATGACTGCC CTAGAAAAGC AGGTGGCAGA AATTTTAAAA 
ATACTGTCGG AAAAAAGCGT ACCCCAGGCC TCATCTCCCA AATCCCAAAT GCCACTCCAA 
GTACCCCCCC AGATACCATG TCAGGATATT TTTAGTGTCT CAAGGCCTGA ATCACCTGAA 
TCTGACAAAG ATGAAATCCA CTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_647479.2
CDS	53..3019
Translation	MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQGDPERNQLQVESRSLQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLLSEDPKSSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQVPPQIPCQDIFSVSRPESPESDKDEIHF

Target ORF information:

RefSeq Version	NM_139318.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily H member 5 (KCNH5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139318.4

ORF Insert Sequence:

ATGCCGGGGG GCAAGAGAGG GCTGGTGGCA CCGCAGAACA CATTTTTGGA GAACATCGTC 
AGGCGCTCCA GTGAATCAAG TTTCTTACTG GGAAATGCCC AGATTGTGGA TTGGCCTGTA 
GTTTATAGTA ATGACGGTTT TTGTAAACTC TCTGGATATC ATCGAGCTGA CGTCATGCAG 
AAAAGCAGCA CTTGCAGTTT TATGTATGGG GAATTGACTG ACAAGAAGAC CATTGAGAAA 
GTCAGGCAAA CTTTTGACAA CTACGAATCA AACTGCTTTG AAGTTCTTCT GTACAAGAAA 
AACAGAACCC CTGTTTGGTT TTATATGCAA ATTGCACCAA TAAGAAATGA ACATGAAAAG 
GTGGTCTTGT TCCTGTGTAC TTTCAAGGAT ATTACGTTGT TCAAACAGCC AATAGAGGAT 
GATTCAACAA AAGGTTGGAC GAAATTTGCC CGATTGACAC GGGCTTTGAC AAATAGCCGA 
AGTGTTTTGC AGCAGCTCAC GCCAATGAAT AAAACAGAGG TGGTCCATAA ACATTCAAGA 
CTAGCTGAAG TTCTTCAGCT GGGATCAGAT ATCCTTCCTC AGTATAAACA AGAAGCGCCA 
AAGACGCCAC CACACATTAT TTTACATTAT TGTGCTTTTA AAACTACTTG GGATTGGGTG 
ATTTTAATTC TTACCTTCTA CACCGCCATT ATGGTTCCTT ATAATGTTTC CTTCAAAACA 
AAGCAGAACA ACATAGCCTG GCTGGTACTG GATAGTGTGG TGGACGTTAT TTTTCTGGTT 
GACATCGTTT TAAATTTTCA CACGACTTTC GTGGGGCCCG GTGGAGAGGT CATTTCTGAC 
CCTAAGCTCA TAAGGATGAA CTATCTGAAA ACTTGGTTTG TGATCGATCT GCTGTCTTGT 
TTACCTTATG ACATCATCAA TGCCTTTGAA AATGTGGATG AGGGAATCAG CAGTCTCTTC 
AGTTCTTTAA AAGTGGTGCG TCTCTTACGA CTGGGCCGTG TGGCTAGGAA ACTGGACCAT 
TACCTAGAAT ATGGAGCAGC AGTCCTCGTG CTCCTGGTGT GTGTGTTTGG ACTGGTGGCC 
CACTGGCTGG CCTGCATATG GTATAGCATC GGAGACTACG AGGTCATTGA TGAAGTCACT 
AACACCATCC AAATAGACAG TTGGCTCTAC CAGCTGGCTT TGAGCATTGG GACTCCATAT 
CGCTACAATA CCAGTGCTGG GATATGGGAA GGAGGACCCA GCAAGGATTC ATTGTACGTG 
TCCTCTCTCT ACTTTACCAT GACAAGCCTT ACAACCATAG GATTTGGAAA CATAGCTCCT 
ACCACAGATG TGGAGAAGAT GTTTTCGGTG GCTATGATGA TGGTTGGCTC TCTTCTTTAT 
GCAACTATTT TTGGAAATGT TACAACAATT TTCCAGCAAA TGTATGCCAA CACCAACCGA 
TACCATGAGA TGCTGAATAA TGTACGGGAC TTCCTAAAAC TCTATCAGGT CCCAAAAGGC 
CTTAGTGAGC GAGTCATGGA TTATATTGTC TCAACATGGT CCATGTCAAA AGGCATTGAT 
ACAGAAAAGG TCCTCTCCAT CTGTCCCAAG GACATGAGAG CTGATATCTG TGTTCATCTA 
AACCGGAAGG TTTTTAATGA ACATCCTGCT TTTCGATTGG CCAGCGATGG GTGTCTGCGC 
GCCTTGGCGG TAGAGTTCCA AACCATTCAC TGTGCTCCCG GGGACCTCAT TTACCATGCT 
GGAGAAAGTG TGGATGCCCT CTGCTTTGTG GTGTCAGGAT CCTTGGAAGT CATCCAGGAT 
GATGAGGTGG TGGCTATTTT AGGGAAGGGT GATGTATTTG GAGACATCTT CTGGAAGGAA 
ACCACCCTTG CCCATGCATG TGCGAACGTC CGGGCACTGA CGTACTGTGA CCTACACATC 
ATCAAGCGGG AAGCCTTGCT CAAAGTCCTG GACTTTTATA CAGCTTTTGC AAACTCCTTC 
TCAAGGAATC TCACTCTTAC TTGCAATCTG AGGAAACGGA TCATCTTTCG TAAGATCAGT 
GATGTGAAGA AAGAGGAGGA GGAGCGCCTC CGGCAGAAGA ATGAGGTGAC CCTCAGCATT 
CCCGTGGACC ACCCAGTCAG AAAGCTCTTC CAGAAGTTCA AGCAGCAGAA GGAGCTGCGG 
AATCAGGGCT CAACACAGGG TGACCCTGAG AGGAACCAAC TCCAGGTAGA GAGCCGCTCC 
TTACAGAATG GAGCCTCCAT CACCGGAACC AGCGTGGTGA CTGTGTCACA GATTACTCCC 
ATTCAGACGT CTCTGGCCTA TGTGAAAACC AGTGAATCCC TTAAGCAGAA CAACCGTGAT 
GCCATGGAAC TCAAGCCCAA CGGCGGTGCT GACCAAAAAT GTCTCAAAGT CAACAGCCCA 
ATAAGAATGA AGAATGGAAA TGGAAAAGGG TGGCTGCGAC TCAAGAATAA TATGGGAGCC 
CATGAGGAGA AAAAGGAAGA CTGGAATAAT GTCACTAAAG CTGAGTCAAT GGGGCTATTG 
TCTGAGGACC CCAAGAGCAG TGATTCAGAG AACAGTGTGA CCAAAAACCC ACTAAGAAAA 
ACAGATTCTT GTGACAGTGG AATTACAAAA AGTGACCTTC GTTTGGATAA GGCTGGGGAG 
GCCCGAAGTC CGCTAGAGCA CAGTCCCATC CAGGCTGATG CCAAGCACCC CTTTTATCCC 
ATCCCCGAGC AGGCCTTACA GACCACACTG CAGGAAGTCA AACACGAACT CAAAGAGGAC 
ATCCAGCTGC TCAGCTGCAG AATGACTGCC CTAGAAAAGC AGGTGGCAGA AATTTTAAAA 
ATACTGTCGG AAAAAAGCGT ACCCCAGGCC TCATCTCCCA AATCCCAAAT GCCACTCCAA 
GTACCCCCCC AGATACCATG TCAGGATATT TTTAGTGTCT CAAGGCCTGA ATCACCTGAA 
TCTGACAAAG ATGAAATCCA CTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.
The Journal of general physiology146(5)357-74(2015 Nov)
Li X,Anishkin A,Liu H,van Rossum DB,Chintapalli SV,Sassic JK,Gallegos D,Pivaroff-Ward K,Jegla T

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
Nature neuroscience18(9)1236-46(2015 Sep)
Huang X,He Y,Dubuc AM,Hashizume R,Zhang W,Reimand J,Yang H,Wang TA,Stehbens SJ,Younger S,Barshow S,Zhu S,Cooper MK,Peacock J,Ramaswamy V,Garzia L,Wu X,Remke M,Forester CM,Kim CC,Weiss WA,James CD,Shuman MA,Bader GD,Mueller S,Taylor MD,Jan YN,Jan LY

A sustained increase in the intracellular Ca?? concentration induces proteolytic cleavage of EAG2 channel.
The international journal of biochemistry & cell biology59126-34(2015 Feb)
Shimizu N,Sato N,Kikuchi T,Ishizaki T,Kobayashi K,Kita K,Takimoto K

The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology24(1)119-27(2015 Jan)
Patel YM,Stram DO,Wilkens LR,Park SS,Henderson BE,Le Marchand L,Haiman CA,Murphy SE

Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene.
PloS one9(4)e95840(2014)
Macaulay EC,Roberts HE,Cheng X,Jeffs AR,Baguley BC,Morison IM

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KCNH5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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