CACNG4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CACNG4
Entrez Gene ID	27092
Full Name	calcium voltage-gated channel auxiliary subunit gamma 4
General protein information	Preferred Names calcium voltage-gated channel auxiliary subunit gamma 4 Names voltage-dependent calcium channel gamma-4 subunit TARP gamma-4 calcium channel, voltage-dependent, gamma subunit 4 neuronal voltage-gated calcium channel gamma-4 subunit transmembrane AMPAR regulatory protein gamma-4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q24.2
Summary	The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010].
Disorder MIM:	606404

mRNA and Protein(s)

mRNA	Protein	Name
NM_014405.4	NP_055220.1	voltage-dependent calcium channel gamma-4 subunit
NM_014405.3	NP_055220.1	voltage-dependent calcium channel gamma-4 subunit

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CACNG4	XP_002696273.1
Pan troglodytes (chimpanzee)	CACNG4	XP_001143986.2
Rattus norvegicus (Norway rat)	Cacng4	NP_542423.1
Canis lupus familiaris (dog)	CACNG4	XP_537582.3
Gallus gallus (chicken)	CACNG4	NP_989463.1
Xenopus tropicalis (tropical clawed frog)	LOC100486554	XP_002943388.2
Homo sapiens (human)	CACNG4	NP_055220.1
Mus musculus (house mouse)	Cacng4	NP_062304.1
Gallus gallus (chicken)	LOC100859571	XP_003642390.1
Danio rerio (zebrafish)	LOC794222	XP_001334133.2

Gene Ontology
Bibliography

Related articles in PubMed

Evaluation of voltage-dependent calcium channel ? gene families identified several novel potential susceptible genes to schizophrenia.
Guan F, Zhang T, Liu X, Han W, Lin H, Li L, Chen G, Li T
Scientific reports624914(2016 04)

Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits.
Yang L, Katchman A, Morrow JP, Doshi D, Marx SO
FASEB journal : official publication of the Federation of American Societies for Experimental Biology25(3)928-36(2011 Mar)

Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.
Kato AS, Gill MB, Ho MT, Yu H, Tu Y, Siuda ER, Wang H, Qian YW, Nisenbaum ES, Tomita S, Bredt DS
Neuron68(6)1082-96(2010 Dec)

Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins.
Sager C, Tapken D, Kott S, Hollmann M
Neuroscience158(1)45-54(2009 Jan)

Calcium channel gamma subunits: a functionally diverse protein family.
Chen RS, Deng TC, Garcia T, Sellers ZM, Best PM
Cell biochemistry and biophysics47(2)178-86(2007)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that CACNG4, CACNG5, CACNG6 and CACNG8 may contribute to the risk of SCZ. The statistical epistasis identified between CACNG5 and CACNG6 suggests that there may be an underlying biological interaction between the two genes.
Title: Evaluation of voltage-dependent calcium channel ? gene families identified several novel potential susceptible genes to schizophrenia.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

examined distribution of the stargazin-like proteins gamma2, gamma3, and gamma4 in human CNS: gamma2 is expressed in cerebellum, cerebral cortex, hippocampus and thalamus, whereas gamma3 abounds in cerebral cortex & amygdala and gamma4 in basal ganglia
Title: Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.

The following CACNG4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CACNG4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00711	NM_014405.4 Latest version!	Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 4 (CACNG4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu00711	NM_014405.3	Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 4 (CACNG4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CACNG4 ( NM_014405.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055220.1 Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 4 (CACNG4), mRNA.

Price & Availability↑

CloneID	OHu00711
Clone ID Related Accession (Same CDS sequence)	NM_014405.4 , NM_014405.3
Accession Version	NM_014405.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	voltage-dependent calcium channel gamma-4 subunit
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005988.1, BC034532.1 and AC005544.1. On Nov 22, 2018 this sequence version replaced NM_014405.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC034532.1, AF162692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262138.4/ ENSP00000262138.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGCGAT GCGACCGCGG GCTGCAGATG CTGCTGACCA CGGCCGGAGC CTTCGCCGCC 
TTCTCGCTCA TGGCCATCGC CATCGGCACC GACTACTGGC TGTACTCCAG CGCGCACATC 
TGCAACGGCA CCAACCTGAC CATGGACGAC GGGCCCCCGC CCCGCCGCGC CCGCGGCGAC 
CTCACCCACT CTGGTCTGTG GCGGGTGTGC TGCATCGAAG GGATCTATAA AGGGCACTGC 
TTCCGGATCA ATCACTTCCC AGAGGACAAT GACTACGACC ACGACAGCTC GGAGTACCTC 
CTCCGCATCG TGCGAGCCTC CAGCGTCTTC CCCATCCTCA GCACCATCCT GCTCCTGCTG 
GGTGGCCTGT GCATCGGTGC TGGCAGGATC TACAGCCGCA AGAACAACAT CGTCCTCAGT 
GCCGGCATCC TCTTCGTGGC TGCAGGCCTC AGTAACATCA TCGGTATCAT CGTCTACATT 
TCCAGCAACA CAGGTGACCC GAGTGACAAG CGGGACGAAG ACAAAAAGAA CCATTACAAC 
TACGGCTGGT CTTTTTACTT TGGAGCTCTG TCTTTCATTG TGGCTGAGAC CGTGGGCGTC 
CTGGCTGTAA ACATTTACAT TGAGAAAAAT AAAGAGTTGA GGTTTAAGAC CAAACGGGAA 
TTCCTTAAGG CGTCTTCCTC TTCTCCTTAT GCCAGGATGC CGAGCTACAG GTACCGGCGA 
CGGCGCTCGA GGTCCAGCTC AAGGTCCACC GAGGCCTCGC CCTCCAGGGA CGTGTCGCCC 
ATGGGCCTGA AGATCACAGG GGCCATCCCC ATGGGGGAGC TGTCCATGTA CACGCTGTCC 
AGGGAGCCCC TCAAGGTGAC CACCGCAGCC AGCTACAGCC CCGACCAGGA GGCCAGCTTC 
CTGCAGGTGC ATGACTTTTT CCAGCAGGAC CTGAAGGAAG GTTTCCACGT CAGCATGCTG 
AACCGACGGA CGACCCCTGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055220.1
CDS	206..1189
Translation	MVRCDRGLQMLLTTAGAFAAFSLMAIAIGTDYWLYSSAHICNGTNLTMDDGPPPRRARGDLTHSGLWRVCCIEGIYKGHCFRINHFPEDNDYDHDSSEYLLRIVRASSVFPILSTILLLLGGLCIGAGRIYSRKNNIVLSAGILFVAAGLSNIIGIIVYISSNTGDPSDKRDEDKKNHYNYGWSFYFGALSFIVAETVGVLAVNIYIEKNKELRFKTKREFLKASSSSPYARMPSYRYRRRRSRSSSRSTEASPSRDVSPMGLKITGAIPMGELSMYTLSREPLKVTTAASYSPDQEASFLQVHDFFQQDLKEGFHVSMLNRRTTPV

Target ORF information:

RefSeq Version	NM_014405.4
Organism	Homo sapiens(human)
Definition	Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 4 (CACNG4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014405.4

ORF Insert Sequence:

ATGGTGCGAT GCGACCGCGG GCTGCAGATG CTGCTGACCA CGGCCGGAGC CTTCGCCGCC 
TTCTCGCTCA TGGCCATCGC CATCGGCACC GACTACTGGC TGTACTCCAG CGCGCACATC 
TGCAACGGCA CCAACCTGAC CATGGACGAC GGGCCCCCGC CCCGCCGCGC CCGCGGCGAC 
CTCACCCACT CTGGTCTGTG GCGGGTGTGC TGCATCGAAG GGATCTATAA AGGGCACTGC 
TTCCGGATCA ATCACTTCCC AGAGGACAAT GACTACGACC ACGACAGCTC GGAGTACCTC 
CTCCGCATCG TGCGAGCCTC CAGCGTCTTC CCCATCCTCA GCACCATCCT GCTCCTGCTG 
GGTGGCCTGT GCATCGGTGC TGGCAGGATC TACAGCCGCA AGAACAACAT CGTCCTCAGT 
GCCGGCATCC TCTTCGTGGC TGCAGGCCTC AGTAACATCA TCGGTATCAT CGTCTACATT 
TCCAGCAACA CAGGTGACCC GAGTGACAAG CGGGACGAAG ACAAAAAGAA CCATTACAAC 
TACGGCTGGT CTTTTTACTT TGGAGCTCTG TCTTTCATTG TGGCTGAGAC CGTGGGCGTC 
CTGGCTGTAA ACATTTACAT TGAGAAAAAT AAAGAGTTGA GGTTTAAGAC CAAACGGGAA 
TTCCTTAAGG CGTCTTCCTC TTCTCCTTAT GCCAGGATGC CGAGCTACAG GTACCGGCGA 
CGGCGCTCGA GGTCCAGCTC AAGGTCCACC GAGGCCTCGC CCTCCAGGGA CGTGTCGCCC 
ATGGGCCTGA AGATCACAGG GGCCATCCCC ATGGGGGAGC TGTCCATGTA CACGCTGTCC 
AGGGAGCCCC TCAAGGTGAC CACCGCAGCC AGCTACAGCC CCGACCAGGA GGCCAGCTTC 
CTGCAGGTGC ATGACTTTTT CCAGCAGGAC CTGAAGGAAG GTTTCCACGT CAGCATGCTG 
AACCGACGGA CGACCCCTGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CACNG4 ( NM_014405.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055220.1 Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 4 (CACNG4), mRNA.

Price & Availability↑

CloneID	OHu00711
Clone ID Related Accession (Same CDS sequence)	NM_014405.4 , NM_014405.3
Accession Version	NM_014405.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	voltage-dependent calcium channel gamma-4 subunit
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005988.1, BC034532.1 and AC005544.1. On Dec 3, 2010 this sequence version replaced NM_014405.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: CD625647.1, BC034532.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGCGAT GCGACCGCGG GCTGCAGATG CTGCTGACCA CGGCCGGAGC CTTCGCCGCC 
TTCTCGCTCA TGGCCATCGC CATCGGCACC GACTACTGGC TGTACTCCAG CGCGCACATC 
TGCAACGGCA CCAACCTGAC CATGGACGAC GGGCCCCCGC CCCGCCGCGC CCGCGGCGAC 
CTCACCCACT CTGGTCTGTG GCGGGTGTGC TGCATCGAAG GGATCTATAA AGGGCACTGC 
TTCCGGATCA ATCACTTCCC AGAGGACAAT GACTACGACC ACGACAGCTC GGAGTACCTC 
CTCCGCATCG TGCGAGCCTC CAGCGTCTTC CCCATCCTCA GCACCATCCT GCTCCTGCTG 
GGTGGCCTGT GCATCGGTGC TGGCAGGATC TACAGCCGCA AGAACAACAT CGTCCTCAGT 
GCCGGCATCC TCTTCGTGGC TGCAGGCCTC AGTAACATCA TCGGTATCAT CGTCTACATT 
TCCAGCAACA CAGGTGACCC GAGTGACAAG CGGGACGAAG ACAAAAAGAA CCATTACAAC 
TACGGCTGGT CTTTTTACTT TGGAGCTCTG TCTTTCATTG TGGCTGAGAC CGTGGGCGTC 
CTGGCTGTAA ACATTTACAT TGAGAAAAAT AAAGAGTTGA GGTTTAAGAC CAAACGGGAA 
TTCCTTAAGG CGTCTTCCTC TTCTCCTTAT GCCAGGATGC CGAGCTACAG GTACCGGCGA 
CGGCGCTCGA GGTCCAGCTC AAGGTCCACC GAGGCCTCGC CCTCCAGGGA CGTGTCGCCC 
ATGGGCCTGA AGATCACAGG GGCCATCCCC ATGGGGGAGC TGTCCATGTA CACGCTGTCC 
AGGGAGCCCC TCAAGGTGAC CACCGCAGCC AGCTACAGCC CCGACCAGGA GGCCAGCTTC 
CTGCAGGTGC ATGACTTTTT CCAGCAGGAC CTGAAGGAAG GTTTCCACGT CAGCATGCTG 
AACCGACGGA CGACCCCTGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055220.1
CDS	49..1032
Translation	MVRCDRGLQMLLTTAGAFAAFSLMAIAIGTDYWLYSSAHICNGTNLTMDDGPPPRRARGDLTHSGLWRVCCIEGIYKGHCFRINHFPEDNDYDHDSSEYLLRIVRASSVFPILSTILLLLGGLCIGAGRIYSRKNNIVLSAGILFVAAGLSNIIGIIVYISSNTGDPSDKRDEDKKNHYNYGWSFYFGALSFIVAETVGVLAVNIYIEKNKELRFKTKREFLKASSSSPYARMPSYRYRRRRSRSSSRSTEASPSRDVSPMGLKITGAIPMGELSMYTLSREPLKVTTAASYSPDQEASFLQVHDFFQQDLKEGFHVSMLNRRTTPV

Target ORF information:

RefSeq Version	NM_014405.3
Organism	Homo sapiens(human)
Definition	Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 4 (CACNG4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014405.3

ORF Insert Sequence:

ATGGTGCGAT GCGACCGCGG GCTGCAGATG CTGCTGACCA CGGCCGGAGC CTTCGCCGCC 
TTCTCGCTCA TGGCCATCGC CATCGGCACC GACTACTGGC TGTACTCCAG CGCGCACATC 
TGCAACGGCA CCAACCTGAC CATGGACGAC GGGCCCCCGC CCCGCCGCGC CCGCGGCGAC 
CTCACCCACT CTGGTCTGTG GCGGGTGTGC TGCATCGAAG GGATCTATAA AGGGCACTGC 
TTCCGGATCA ATCACTTCCC AGAGGACAAT GACTACGACC ACGACAGCTC GGAGTACCTC 
CTCCGCATCG TGCGAGCCTC CAGCGTCTTC CCCATCCTCA GCACCATCCT GCTCCTGCTG 
GGTGGCCTGT GCATCGGTGC TGGCAGGATC TACAGCCGCA AGAACAACAT CGTCCTCAGT 
GCCGGCATCC TCTTCGTGGC TGCAGGCCTC AGTAACATCA TCGGTATCAT CGTCTACATT 
TCCAGCAACA CAGGTGACCC GAGTGACAAG CGGGACGAAG ACAAAAAGAA CCATTACAAC 
TACGGCTGGT CTTTTTACTT TGGAGCTCTG TCTTTCATTG TGGCTGAGAC CGTGGGCGTC 
CTGGCTGTAA ACATTTACAT TGAGAAAAAT AAAGAGTTGA GGTTTAAGAC CAAACGGGAA 
TTCCTTAAGG CGTCTTCCTC TTCTCCTTAT GCCAGGATGC CGAGCTACAG GTACCGGCGA 
CGGCGCTCGA GGTCCAGCTC AAGGTCCACC GAGGCCTCGC CCTCCAGGGA CGTGTCGCCC 
ATGGGCCTGA AGATCACAGG GGCCATCCCC ATGGGGGAGC TGTCCATGTA CACGCTGTCC 
AGGGAGCCCC TCAAGGTGAC CACCGCAGCC AGCTACAGCC CCGACCAGGA GGCCAGCTTC 
CTGCAGGTGC ATGACTTTTT CCAGCAGGAC CTGAAGGAAG GTTTCCACGT CAGCATGCTG 
AACCGACGGA CGACCCCTGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evaluation of voltage-dependent calcium channel ? gene families identified several novel potential susceptible genes to schizophrenia.
Scientific reports624914(2016 04)
Guan F,Zhang T,Liu X,Han W,Lin H,Li L,Chen G,Li T

Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology25(3)928-36(2011 Mar)
Yang L,Katchman A,Morrow JP,Doshi D,Marx SO

Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.
Neuron68(6)1082-96(2010 Dec)
Kato AS,Gill MB,Ho MT,Yu H,Tu Y,Siuda ER,Wang H,Qian YW,Nisenbaum ES,Tomita S,Bredt DS

Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins.
Neuroscience158(1)45-54(2009 Jan)
Sager C,Tapken D,Kott S,Hollmann M

Calcium channel gamma subunits: a functionally diverse protein family.
Cell biochemistry and biophysics47(2)178-86(2007)
Chen RS,Deng TC,Garcia T,Sellers ZM,Best PM

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CACNG4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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