UQCRQ cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UQCRQ
Entrez Gene ID	27089
Full Name	ubiquinol-cytochrome c reductase complex III subunit VII
Synonyms	MC3DN4,QCR8,QP-C,QPC,UQCR7
General protein information	Preferred Names ubiquinol-cytochrome c reductase complex III subunit VII Names cytochrome b-c1 complex subunit 8 complex III subunit 8 complex III subunit VIII low molecular mass ubiquinone-binding protein (9.5kD) ubiquinol-cytochrome c reductase complex 9.5 kDa protein ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.1
Summary	This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008].
Disorder MIM:	612080
Disorder Html:	Mitochondrial complex III deficiency, nuclear type 4, 615159 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_014402.5	NP_055217.2	cytochrome b-c1 complex subunit 8
NM_014402.4	NP_055217.2	cytochrome b-c1 complex subunit 8

Pathways from BioSystems

Homologies

Homo sapiens (human)	UQCRQ	NP_055217.2
Pan troglodytes (chimpanzee)	UQCRQ	XP_527009.2
	LOC695665	XP_001085732.1
Canis lupus familiaris (dog)	UQCRQ	XP_852164.1
Gallus gallus (chicken)	LOC100858114	XP_003642138.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010337	XP_311607.2
Rattus norvegicus (Norway rat)	Uqcrq	NP_001020305.1
Danio rerio (zebrafish)	uqcrq	NP_001002495.2
Xenopus tropicalis (tropical clawed frog)	uqcrq	NP_001016654.1
Drosophila melanogaster (fruit fly)	CG7580	NP_001189125.1
Bos taurus (cattle)	UQCRQ	NP_777230.1
Mus musculus (house mouse)	Uqcrq	NP_079628.1
Gallus gallus (chicken)	UQCRQ	XP_414651.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of Genes Expressed in Hyperpigmented Skin Using Meta-Analysis of Microarray Data Sets.
Yin L, Coelho SG, Valencia JC, Ebsen D, Mahns A, Smuda C, Miller SA, Beer JZ, Kolbe L, Hearing VJ
The Journal of investigative dermatology135(10)2455-2463(2015 Oct)

Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis.
Sifroni KG, Damiani CR, Stoffel C, Cardoso MR, Ferreira GK, Jeremias IC, Rezin GT, Scaini G, Schuck PF, Dal-Pizzol F, Streck EL
Molecular and cellular biochemistry342(1-2)111-5(2010 Sep)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Mitochondrial complex III deficiency associated with a homozygous mutation in UQCRQ.
Barel O, Shorer Z, Flusser H, Ofir R, Narkis G, Finer G, Shalev H, Nasasra A, Saada A, Birk OS
American journal of human genetics82(5)1211-6(2008 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

QP-C protein gene expression involved in the development of hyperpigmentation.
Title: Identification of Genes Expressed in Hyperpigmented Skin Using Meta-Analysis of Microarray Data Sets.

Decreased electron Transport Complex III activity is associated with ulcerative colitis.
Title: Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

We thus suggest that a homozygous mutation in UQCRQ is associated with defective function of mitochondrial complex III, leading to a severe autosomal-recessive neurological phenotype.
Title: Mitochondrial complex III deficiency associated with a homozygous mutation in UQCRQ.

The following UQCRQ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UQCRQ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27789	NM_014402.5 Latest version!	Homo sapiens ubiquinol-cytochrome c reductase complex III subunit VII (UQCRQ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27789	NM_014402.4	Homo sapiens ubiquinol-cytochrome c reductase complex III subunit VII (UQCRQ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UQCRQ ( NM_014402.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055217.2 Homo sapiens ubiquinol-cytochrome c reductase complex III subunit VII (UQCRQ), mRNA.

Price & Availability↑

CloneID	OHu27789
Clone ID Related Accession (Same CDS sequence)	NM_014402.5 , NM_014402.4
Accession Version	NM_014402.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 249bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	cytochrome b-c1 complex subunit 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU953465.1, CR743513.1, BU190580.1 and AC004500.1. This sequence is a reference standard in the RefSeqGene project. On Nov 24, 2018 this sequence version replaced NM_014402.4. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.63876.1, SRR1803611.53820.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000378670.8/ ENSP00000367939.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCCGCG AGTTTGGGAA TCTGACGCGG ATGCGGCATG TGATCAGCTA CAGCTTGTCA 
CCGTTCGAGC AGCGCGCCTA TCCGCACGTC TTCACTAAAG GAATCCCCAA TGTTCTGCGC 
CGCATTCGGG AGTCTTTCTT TCGCGTGGTG CCGCAGTTTG TAGTGTTTTA TCTTATCTAC 
ACATGGGGGA CTGAAGAGTT CGAGAGATCC AAGAGGAAGA ATCCAGCTGC CTATGAAAAT 
GACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055217.2
CDS	60..308
Translation	MGREFGNLTRMRHVISYSLSPFEQRAYPHVFTKGIPNVLRRIRESFFRVVPQFVVFYLIYTWGTEEFERSKRKNPAAYENDK

Target ORF information:

RefSeq Version	NM_014402.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquinol-cytochrome c reductase complex III subunit VII (UQCRQ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014402.5

ORF Insert Sequence:

ATGGGCCGCG AGTTTGGGAA TCTGACGCGG ATGCGGCATG TGATCAGCTA CAGCTTGTCA 
CCGTTCGAGC AGCGCGCCTA TCCGCACGTC TTCACTAAAG GAATCCCCAA TGTTCTGCGC 
CGCATTCGGG AGTCTTTCTT TCGCGTGGTG CCGCAGTTTG TAGTGTTTTA TCTTATCTAC 
ACATGGGGGA CTGAAGAGTT CGAGAGATCC AAGAGGAAGA ATCCAGCTGC CTATGAAAAT 
GACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UQCRQ ( NM_014402.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055217.2 Homo sapiens ubiquinol-cytochrome c reductase complex III subunit VII (UQCRQ), mRNA.

Price & Availability↑

CloneID	OHu27789
Clone ID Related Accession (Same CDS sequence)	NM_014402.5 , NM_014402.4
Accession Version	NM_014402.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 249bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	cytochrome b-c1 complex subunit 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU953465.1, CR743513.1, BU190580.1 and AC004500.1. This sequence is a reference standard in the RefSeqGene project. On May 19, 2006 this sequence version replaced NM_014402.3. ##Evidence-Data-START## Transcript exon combination :: BP294955.1, SRR1803611.53820.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCCGCG AGTTTGGGAA TCTGACGCGG ATGCGGCATG TGATCAGCTA CAGCTTGTCA 
CCGTTCGAGC AGCGCGCCTA TCCGCACGTC TTCACTAAAG GAATCCCCAA TGTTCTGCGC 
CGCATTCGGG AGTCTTTCTT TCGCGTGGTG CCGCAGTTTG TAGTGTTTTA TCTTATCTAC 
ACATGGGGGA CTGAAGAGTT CGAGAGATCC AAGAGGAAGA ATCCAGCTGC CTATGAAAAT 
GACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055217.2
CDS	75..323
Translation	MGREFGNLTRMRHVISYSLSPFEQRAYPHVFTKGIPNVLRRIRESFFRVVPQFVVFYLIYTWGTEEFERSKRKNPAAYENDK

Target ORF information:

RefSeq Version	NM_014402.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquinol-cytochrome c reductase complex III subunit VII (UQCRQ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014402.4

ORF Insert Sequence:

ATGGGCCGCG AGTTTGGGAA TCTGACGCGG ATGCGGCATG TGATCAGCTA CAGCTTGTCA 
CCGTTCGAGC AGCGCGCCTA TCCGCACGTC TTCACTAAAG GAATCCCCAA TGTTCTGCGC 
CGCATTCGGG AGTCTTTCTT TCGCGTGGTG CCGCAGTTTG TAGTGTTTTA TCTTATCTAC 
ACATGGGGGA CTGAAGAGTT CGAGAGATCC AAGAGGAAGA ATCCAGCTGC CTATGAAAAT 
GACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of Genes Expressed in Hyperpigmented Skin Using Meta-Analysis of Microarray Data Sets.
The Journal of investigative dermatology135(10)2455-2463(2015 Oct)
Yin L,Coelho SG,Valencia JC,Ebsen D,Mahns A,Smuda C,Miller SA,Beer JZ,Kolbe L,Hearing VJ

Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis.
Molecular and cellular biochemistry342(1-2)111-5(2010 Sep)
Sifroni KG,Damiani CR,Stoffel C,Cardoso MR,Ferreira GK,Jeremias IC,Rezin GT,Scaini G,Schuck PF,Dal-Pizzol F,Streck EL

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Mitochondrial complex III deficiency associated with a homozygous mutation in UQCRQ.
American journal of human genetics82(5)1211-6(2008 May)
Barel O,Shorer Z,Flusser H,Ofir R,Narkis G,Finer G,Shalev H,Nasasra A,Saada A,Birk OS

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UQCRQ cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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