NPHP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NPHP3
Entrez Gene ID	27031
Full Name	nephrocystin 3
Synonyms	CFAP31,MKS7,NPH3,RHPD,RHPD1,SLSN3
General protein information	Preferred Names nephrocystin 3 Names nephrocystin-3 Meckel syndrome, type 7 cilia and flagella associated protein 31 nephronophthisis 3 (adolescent)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q22.1
Summary	This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin, it is required for normal ciliary development, and it functions in renal tubular development. Mutations in this gene are associated with nephronophthisis type 3, and also with renal-hepatic-pancreatic dysplasia, and Meckel syndrome type 7. Naturally occurring read-through transcripts exist between this gene and the downstream ACAD11 (acyl-CoA dehydrogenase family, member 11) gene. [provided by RefSeq, Feb 2011].
Disorder MIM:	608002
Disorder Html:	Nephronophthisis 3, 604387 (3); Renal-hepatic-pancreatic dysplasia 1, 208540 (3); Meckel syndrome 7, 267010 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_153240.5	NP_694972.3	nephrocystin-3
NM_153240.4	NP_694972.3	nephrocystin-3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Nphp3	NP_001178811.1
Homo sapiens (human)	NPHP3	NP_694972.3
Canis lupus familiaris (dog)	NPHP3	XP_003639875.1
Mus musculus (house mouse)	Nphp3	NP_082997.3
Pan troglodytes (chimpanzee)	NPHP3	XP_516758.4
Gallus gallus (chicken)	NPHP3	XP_418790.2
Xenopus tropicalis (tropical clawed frog)	nphp3	NP_001072733.2
Bos taurus (cattle)	NPHP3	NP_001179081.1
Danio rerio (zebrafish)	nphp3	NP_001189370.1

Gene Ontology
Bibliography

Related articles in PubMed

Homozygous mutation in the NPHP3 gene causing foetal nephronophthisis.
Abdullah U, Farooq M, Fatima A, Tauseef W, Sarwar Y, Nuri M, Tommerup N, Baig SM
Nephrology (Carlton, Vic.)22(10)818-820(2017 Oct)

A familial case of severe infantile nephronophthisis explained by oligogenic inheritance.
Penchev V, Boueva A, Kamenarova K, Roussinov D, Tzveova R, Ivanova M, Dimitrova V, Kremensky I, Mitev V, Kaneva R, Beltcheva O
European journal of medical genetics60(6)321-325(2017 Jun)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

High mutation rate of NPHP3 in 18 Chinese infantile nephronophthisis patients.
Sun L, Tong H, Wang H, Yue Z, Liu T, Lin H, Li J, Wang C
Nephrology (Carlton, Vic.)21(3)209-16(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inherited 3 deleterious mutations in two nephronophthisis genes, NPHP3 and NPHP4 cause unusually severe form of infantile nephronophthisis.
Title: A familial case of severe infantile nephronophthisis explained by oligogenic inheritance.

NPHP3 mutations were prevalent in Chinese infantile nephronophthisis patients. All patients with NPHP3 mutations showed renal-hepatic phenotype.
Title: High mutation rate of NPHP3 in 18 Chinese infantile nephronophthisis patients.

a rare neonatal ciliopathy presentation of NPHP3 mutations leading to severe multiorgan failure in two siblings.
Title: NPHP3 mutations are associated with neonatal onset multiorgan polycystic disease in two siblings.

ANKS6 as a new NPHP family member that assembles a distinct module of nephronophthisis-associated proteins, encompassing NEK8, INVS and NPHP3.
Title: ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3.

The known phenotype of NPHP3 mutation caused renal-hepatic-pancreatic dysplasia has been extended to include skeletal and CNS anomalies.
Title: Renal-hepatic-pancreatic dysplasia: a sibship with skeletal and central nervous system anomalies and NPHP3 mutation.

The following NPHP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NPHP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20735	NM_153240.5 Latest version!	Homo sapiens nephrocystin 3 (NPHP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$923.30 $1319.00
View Old Accession Versions >>
OHu20735	NM_153240.4	Homo sapiens nephrocystin 3 (NPHP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$923.30 $1319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NPHP3 ( NM_153240.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_694972.3 Homo sapiens nephrocystin 3 (NPHP3), mRNA.

Price & Availability↑

CloneID	OHu20735
Clone ID Related Accession (Same CDS sequence)	NM_153240.5 , NM_153240.4
Accession Version	NM_153240.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	nephrocystin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB114822.1, AY257864.1, AC055732.16 and EB387619.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_153240.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.95967.1, AY257864.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000337331.10/ ENSP00000338766.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGACCG CCTCGTCGCT CGTGAGCCCC GCGGGCGGGG AAGTGATCGA GGACACGTAC 
GGGGCGGGCG GCGGCGAGGC CTGCGAGATC CCGGTGGAGG TGAAGCCCAA GGCCCGCCTG 
CTGCGCAACT CGTTCCGCCG AGGCGCGGGG GCGGCAGCAG GGGCCGGGCC CGGGTCGCTG 
CCCCGCGGGG TGGGCGCGGG CGGGCTGCTG GGGGCCAGCT TCAAGTCCAC TGGCTCGTCG 
GTGCCAGAGC TGGAGTACGC GGCGGCCGAG TACGAGCGGC TCAGGAAGGA GTACGAGATC 
TTTCGCGTCA GCAAGAACCA GGAGTTGTTG TCCATGGGCC GCCGCGAGGC CAAGCTGGAC 
ACGGAGAACA AGCGGCTGCG GGCCGAACTG CAGGCACTTC AAAAAACGTA TCAGAAGATA 
CTTCGAGAAA AAGAAAGTGC TTTAGAAGCG AAATACCAAG CAATGGAGAG AGCAGCAACA 
TTTGAACATG ACAGAGATAA AGTTAAAAGG CAATTCAAGA TTTTTAGGGA GACCAAAGAA 
AATGAAATTC AGGACTTACT GAGGGCCAAG AGGGAGTTGG AGAGCAAACT TCAGAGGCTA 
CAGGCTCAGG GTATCCAAGT ATTTGATCCT GGGGAGTCTG ATTCAGATGA CAACTGTACA 
GATGTCACTG CTGCTGGAAC CCAATGTGAA TATTGGACTG GCGGAGCCTT GGGAAGTGAA 
CCTTCCATAG GAAGCATGAT CCAGCTTCAG CAGTCCTTCA GAGGCCCTGA GTTTGCCCAT 
AGTTCTATAG ATGTGGAAGG ACCCTTTGCA AATGTTAATA GAGATGACTG GGATATTGCT 
GTAGCTAGTT TATTACAAGT TACTCCTCTG TTTTCACATT CTCTGTGGAG TAACACTGTC 
AGATGTTACC TCATTTATAC AGATGAAACC CAGCCTGAGA TGGATCTTTT CCTTAAGGAC 
TATTCACCTA AACTTAAGAG AATGTGCGAG ACAATGGGAT ATTTTTTCCA TGCTGTTTAT 
TTTCCAATAG ATGTTGAAAA TCAATACCTC ACTGTAAGAA AATGGGAAAT TGAGAAAAGT 
TCTTTAGTTA TTTTATTTAT TCACTTAACA TTACCAAGCC TTTTATTGGA AGACTGTGAA 
GAAGCTTTTC TGAAAAACCC TGAAGGAAAA CCTCGATTAA TCTTTCATCG TTTGGAAGAT 
GGAAAAGTCA GTTCTGACTC TGTCCAGCAA TTGATTGATC AAGTTTCTAA TCTAAACAAG 
ACCAGCAAAG CCAAGATCAT TGATCACTCA GGAGATCCTG CAGAAGGAGT ATATAAAACT 
TATATTTGTG TAGAAAAGAT TATTAAACAG GACATACTGG GTTTTGAGAA CACAGACTTG 
GAGACTAAGG ATTTGGGCAG TGAGGATTCC ATTCCAGAAG AAGATGATTT TGGTGATGTT 
CTGTGGGACA TACATGATGA ACAAGAGCAA ATGGAAACTT TTCAGCAGGC TTCTAATTCA 
GCCCATGAGT TGGGATTTGA GAAATATTAC CAACGCCTTA ATGATCTAGT GGCAGCACCA 
GCCCCGATTC CACCTCTTCT CGTGTCTGGA GGACCAGGTT CTGGGAAGTC TCTTCTTTTA 
TCAAAGTGGA TTCAATTACA ACAGAAGAAT TCCCCCAACA CACTGATTCT TTCCCATTTT 
GTGGGAAGGC CCATGTCAAC CAGCTCAGAG TCCTCCTTGA TTATTAAACG ACTAACTCTA 
AAGTTGATGC AGCACTCTTG GTCAGTCTCT GCTCTGACAC TGGATCCTGC TAAGCTTCTG 
GAAGAATTTC CACGTTGGCT GGAAAAACTC TCTGCTCGTC ATCAAGGCAG CATCATCATC 
GTTATTGATT CTATAGATCA AGTTCAGCAA GTTGAAAAAC ACATGAAATG GCTGATAGAT 
CCACTGCCAG TGAATGTAAG AGTAATTGTT TCTGTGAATG TAGAAACATG CCCTCCAGCA 
TGGAGGTTGT GGCCTACACT TCATCTTGAT CCCTTAAGTC CAAAAGATGC AAAATCTATT 
ATAATTGCAG AATGCCACTC TGTAGACATT AAATTGAGTA AAGAGCAGGA GAAGAAGCTA 
GAACGACACT GTCGTTCTGC TACAACCTGC AATGCCCTTT ATGTCACCCT TTTCGGCAAA 
ATGATCGCGC GTGCTGGGAG AGCAGGCAAT TTAGATAAAA TCCTTCATCA GTGTTTCCAG 
TGTCAAGATA CTCTTTCATT ATATAGACTT GTTCTGCACT CTATCCGGGA GTCCATGGCA 
AATGATGTGG ATAAAGAGCT AATGAAGCAG ATCCTCTGCC TTGTCAATGT TAGTCACAAT 
GGTGTGAGTG AATCAGAACT GATGGAACTC TATCCTGAGA TGTCCTGGAC TTTCTTGACC 
TCCCTTATTC ACAGTTTATA CAAAATGTGT TTGTTGACTT ATGGATGTGG CTTGCTTAGG 
TTTCAACATC TGCAGGCTTG GGAAACAGTG AGATTGGAGT ACCTGGAAGG CCCCACTGTT 
ACTTCTTCAT ACAGGCAAAA GCTAATCAAC TATTTCACCT TGCAGCTAAG TCAGGACAGA 
GTGACTTGGA GAAGTGCAGA TGAACTCCCG TGGCTTTTTC AGCAGCAGGG AAGTAAACAG 
AAGCTGCATG ATTGCCTTCT TAATCTCTTT GTGTCTCAAA ACCTTTATAA AAGGGGACAC 
TTTGCTGAGT TGCTGAGTTA TTGGCAGTTT GTTGGCAAAG ACAAAAGTGC AATGGCAACA 
GAATACTTCG ATTCATTGAA GCAGTATGAG AAAAACTGCG AAGGCGAGGA CAACATGAGT 
TGCTTAGCTG ATCTTTATGA AACCTTGGGG CGATTTCTCA AGGATCTAGG CCTTCTCAGT 
CAGGCCATAG TACCTTTGCA GAGGTCTTTA GAGATTCGAG AAACAGCTTT AGATCCCGAT 
CACCCAAGAG TAGCCCAGTC CCTCCACCAA CTAGCAAGTG TATACGTGCA GTGGAAGAAG 
TTTGGCAATG CAGAACAACT GTATAAACAG GCGTTGGAAA TCTCAGAAAA TGCTTATGGT 
GCGGACCATC CATATACTGC TCGTGAACTT GAAGCACTTG CAACTTTGTA CCAGAAACAA 
AATAAATATG AACAAGCTGA ACATTTTAGG AAAAAATCCT TTAAAATTCA TCAGAAAGCT 
ATAAAGAAAA AAGGCAACTT GTACGGATTT GCCCTTTTAC GTAGACGGGC TTTACAGTTA 
GAAGAGCTTA CATTAGGTAA GGACACACCT GATAATGCTC GGACCCTCAA TGAACTGGGT 
GTTCTCTACT ATCTTCAAAA TAACCTGGAA ACAGCTGACC AGTTTCTGAA GCGTTCCTTA 
GAAATGAGGG AGCGAGTTCT AGGACCAGAT CACCCTGACT GTGCTCAGTC TTTGAATAAT 
CTGGCAGCTC TATGCAATGA AAAGAAACAG TATGATAAAG CAGAAGAACT TTATGAAAGA 
GCTTTAGATA TTCGGAGACG TGCATTAGCT CCTGATCACC CTTCTTTGGC ATATACGGTG 
AAGCATCTTG CCATCTTGTA TAAGAAAATG GGGAAACTTG ACAAAGCTGT ACCTTTGTAT 
GAATTGGCTG TTGAAATTCG ACAGAAATCT TTTGGCCCAA AGCACCCTAG TGTAGCTACT 
GCCTTGGTGA ACTTAGCTGT TCTTTATAGC CAAATGAAAA AACACGTTGA AGCTTTGCCA 
TTATATGAAA GAGCATTAAA GATTTATGAA GATAGCCTGG GTCGGATGCA TCCTCGAGTT 
GGAGAAACAC TGAAAAATTT AGCTGTGCTT AGCTATGAAG GAGGAGATTT TGAAAAAGCT 
GCTGAATTAT ACAAAAGGGC AATGGAAATA AAAGAAGCAG AAACATCACT CTTGGGTGGA 
AAAGCTCCTT CACGCCATTC ATCAAGTGGA GACACGTTTA GCTTAAAAAC AGCTCATTCT 
CCTAATGTTT TCCTTCAGCA AGGACAAAGG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694972.3
CDS	55..4047
Translation	MGTASSLVSPAGGEVIEDTYGAGGGEACEIPVEVKPKARLLRNSFRRGAGAAAGAGPGSLPRGVGAGGLLGASFKSTGSSVPELEYAAAEYERLRKEYEIFRVSKNQELLSMGRREAKLDTENKRLRAELQALQKTYQKILREKESALEAKYQAMERAATFEHDRDKVKRQFKIFRETKENEIQDLLRAKRELESKLQRLQAQGIQVFDPGESDSDDNCTDVTAAGTQCEYWTGGALGSEPSIGSMIQLQQSFRGPEFAHSSIDVEGPFANVNRDDWDIAVASLLQVTPLFSHSLWSNTVRCYLIYTDETQPEMDLFLKDYSPKLKRMCETMGYFFHAVYFPIDVENQYLTVRKWEIEKSSLVILFIHLTLPSLLLEDCEEAFLKNPEGKPRLIFHRLEDGKVSSDSVQQLIDQVSNLNKTSKAKIIDHSGDPAEGVYKTYICVEKIIKQDILGFENTDLETKDLGSEDSIPEEDDFGDVLWDIHDEQEQMETFQQASNSAHELGFEKYYQRLNDLVAAPAPIPPLLVSGGPGSGKSLLLSKWIQLQQKNSPNTLILSHFVGRPMSTSSESSLIIKRLTLKLMQHSWSVSALTLDPAKLLEEFPRWLEKLSARHQGSIIIVIDSIDQVQQVEKHMKWLIDPLPVNVRVIVSVNVETCPPAWRLWPTLHLDPLSPKDAKSIIIAECHSVDIKLSKEQEKKLERHCRSATTCNALYVTLFGKMIARAGRAGNLDKILHQCFQCQDTLSLYRLVLHSIRESMANDVDKELMKQILCLVNVSHNGVSESELMELYPEMSWTFLTSLIHSLYKMCLLTYGCGLLRFQHLQAWETVRLEYLEGPTVTSSYRQKLINYFTLQLSQDRVTWRSADELPWLFQQQGSKQKLHDCLLNLFVSQNLYKRGHFAELLSYWQFVGKDKSAMATEYFDSLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETSLLGGKAPSRHSSSGDTFSLKTAHSPNVFLQQGQR

Target ORF information:

RefSeq Version	NM_153240.5
Organism	Homo sapiens(human)
Definition	Homo sapiens nephrocystin 3 (NPHP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153240.5

ORF Insert Sequence:

ATGGGGACCG CCTCGTCGCT CGTGAGCCCC GCGGGCGGGG AAGTGATCGA GGACACGTAC 
GGGGCGGGCG GCGGCGAGGC CTGCGAGATC CCGGTGGAGG TGAAGCCCAA GGCCCGCCTG 
CTGCGCAACT CGTTCCGCCG AGGCGCGGGG GCGGCAGCAG GGGCCGGGCC CGGGTCGCTG 
CCCCGCGGGG TGGGCGCGGG CGGGCTGCTG GGGGCCAGCT TCAAGTCCAC TGGCTCGTCG 
GTGCCAGAGC TGGAGTACGC GGCGGCCGAG TACGAGCGGC TCAGGAAGGA GTACGAGATC 
TTTCGCGTCA GCAAGAACCA GGAGTTGTTG TCCATGGGCC GCCGCGAGGC CAAGCTGGAC 
ACGGAGAACA AGCGGCTGCG GGCCGAACTG CAGGCACTTC AAAAAACGTA TCAGAAGATA 
CTTCGAGAAA AAGAAAGTGC TTTAGAAGCG AAATACCAAG CAATGGAGAG AGCAGCAACA 
TTTGAACATG ACAGAGATAA AGTTAAAAGG CAATTCAAGA TTTTTAGGGA GACCAAAGAA 
AATGAAATTC AGGACTTACT GAGGGCCAAG AGGGAGTTGG AGAGCAAACT TCAGAGGCTA 
CAGGCTCAGG GTATCCAAGT ATTTGATCCT GGGGAGTCTG ATTCAGATGA CAACTGTACA 
GATGTCACTG CTGCTGGAAC CCAATGTGAA TATTGGACTG GCGGAGCCTT GGGAAGTGAA 
CCTTCCATAG GAAGCATGAT CCAGCTTCAG CAGTCCTTCA GAGGCCCTGA GTTTGCCCAT 
AGTTCTATAG ATGTGGAAGG ACCCTTTGCA AATGTTAATA GAGATGACTG GGATATTGCT 
GTAGCTAGTT TATTACAAGT TACTCCTCTG TTTTCACATT CTCTGTGGAG TAACACTGTC 
AGATGTTACC TCATTTATAC AGATGAAACC CAGCCTGAGA TGGATCTTTT CCTTAAGGAC 
TATTCACCTA AACTTAAGAG AATGTGCGAG ACAATGGGAT ATTTTTTCCA TGCTGTTTAT 
TTTCCAATAG ATGTTGAAAA TCAATACCTC ACTGTAAGAA AATGGGAAAT TGAGAAAAGT 
TCTTTAGTTA TTTTATTTAT TCACTTAACA TTACCAAGCC TTTTATTGGA AGACTGTGAA 
GAAGCTTTTC TGAAAAACCC TGAAGGAAAA CCTCGATTAA TCTTTCATCG TTTGGAAGAT 
GGAAAAGTCA GTTCTGACTC TGTCCAGCAA TTGATTGATC AAGTTTCTAA TCTAAACAAG 
ACCAGCAAAG CCAAGATCAT TGATCACTCA GGAGATCCTG CAGAAGGAGT ATATAAAACT 
TATATTTGTG TAGAAAAGAT TATTAAACAG GACATACTGG GTTTTGAGAA CACAGACTTG 
GAGACTAAGG ATTTGGGCAG TGAGGATTCC ATTCCAGAAG AAGATGATTT TGGTGATGTT 
CTGTGGGACA TACATGATGA ACAAGAGCAA ATGGAAACTT TTCAGCAGGC TTCTAATTCA 
GCCCATGAGT TGGGATTTGA GAAATATTAC CAACGCCTTA ATGATCTAGT GGCAGCACCA 
GCCCCGATTC CACCTCTTCT CGTGTCTGGA GGACCAGGTT CTGGGAAGTC TCTTCTTTTA 
TCAAAGTGGA TTCAATTACA ACAGAAGAAT TCCCCCAACA CACTGATTCT TTCCCATTTT 
GTGGGAAGGC CCATGTCAAC CAGCTCAGAG TCCTCCTTGA TTATTAAACG ACTAACTCTA 
AAGTTGATGC AGCACTCTTG GTCAGTCTCT GCTCTGACAC TGGATCCTGC TAAGCTTCTG 
GAAGAATTTC CACGTTGGCT GGAAAAACTC TCTGCTCGTC ATCAAGGCAG CATCATCATC 
GTTATTGATT CTATAGATCA AGTTCAGCAA GTTGAAAAAC ACATGAAATG GCTGATAGAT 
CCACTGCCAG TGAATGTAAG AGTAATTGTT TCTGTGAATG TAGAAACATG CCCTCCAGCA 
TGGAGGTTGT GGCCTACACT TCATCTTGAT CCCTTAAGTC CAAAAGATGC AAAATCTATT 
ATAATTGCAG AATGCCACTC TGTAGACATT AAATTGAGTA AAGAGCAGGA GAAGAAGCTA 
GAACGACACT GTCGTTCTGC TACAACCTGC AATGCCCTTT ATGTCACCCT TTTCGGCAAA 
ATGATCGCGC GTGCTGGGAG AGCAGGCAAT TTAGATAAAA TCCTTCATCA GTGTTTCCAG 
TGTCAAGATA CTCTTTCATT ATATAGACTT GTTCTGCACT CTATCCGGGA GTCCATGGCA 
AATGATGTGG ATAAAGAGCT AATGAAGCAG ATCCTCTGCC TTGTCAATGT TAGTCACAAT 
GGTGTGAGTG AATCAGAACT GATGGAACTC TATCCTGAGA TGTCCTGGAC TTTCTTGACC 
TCCCTTATTC ACAGTTTATA CAAAATGTGT TTGTTGACTT ATGGATGTGG CTTGCTTAGG 
TTTCAACATC TGCAGGCTTG GGAAACAGTG AGATTGGAGT ACCTGGAAGG CCCCACTGTT 
ACTTCTTCAT ACAGGCAAAA GCTAATCAAC TATTTCACCT TGCAGCTAAG TCAGGACAGA 
GTGACTTGGA GAAGTGCAGA TGAACTCCCG TGGCTTTTTC AGCAGCAGGG AAGTAAACAG 
AAGCTGCATG ATTGCCTTCT TAATCTCTTT GTGTCTCAAA ACCTTTATAA AAGGGGACAC 
TTTGCTGAGT TGCTGAGTTA TTGGCAGTTT GTTGGCAAAG ACAAAAGTGC AATGGCAACA 
GAATACTTCG ATTCATTGAA GCAGTATGAG AAAAACTGCG AAGGCGAGGA CAACATGAGT 
TGCTTAGCTG ATCTTTATGA AACCTTGGGG CGATTTCTCA AGGATCTAGG CCTTCTCAGT 
CAGGCCATAG TACCTTTGCA GAGGTCTTTA GAGATTCGAG AAACAGCTTT AGATCCCGAT 
CACCCAAGAG TAGCCCAGTC CCTCCACCAA CTAGCAAGTG TATACGTGCA GTGGAAGAAG 
TTTGGCAATG CAGAACAACT GTATAAACAG GCGTTGGAAA TCTCAGAAAA TGCTTATGGT 
GCGGACCATC CATATACTGC TCGTGAACTT GAAGCACTTG CAACTTTGTA CCAGAAACAA 
AATAAATATG AACAAGCTGA ACATTTTAGG AAAAAATCCT TTAAAATTCA TCAGAAAGCT 
ATAAAGAAAA AAGGCAACTT GTACGGATTT GCCCTTTTAC GTAGACGGGC TTTACAGTTA 
GAAGAGCTTA CATTAGGTAA GGACACACCT GATAATGCTC GGACCCTCAA TGAACTGGGT 
GTTCTCTACT ATCTTCAAAA TAACCTGGAA ACAGCTGACC AGTTTCTGAA GCGTTCCTTA 
GAAATGAGGG AGCGAGTTCT AGGACCAGAT CACCCTGACT GTGCTCAGTC TTTGAATAAT 
CTGGCAGCTC TATGCAATGA AAAGAAACAG TATGATAAAG CAGAAGAACT TTATGAAAGA 
GCTTTAGATA TTCGGAGACG TGCATTAGCT CCTGATCACC CTTCTTTGGC ATATACGGTG 
AAGCATCTTG CCATCTTGTA TAAGAAAATG GGGAAACTTG ACAAAGCTGT ACCTTTGTAT 
GAATTGGCTG TTGAAATTCG ACAGAAATCT TTTGGCCCAA AGCACCCTAG TGTAGCTACT 
GCCTTGGTGA ACTTAGCTGT TCTTTATAGC CAAATGAAAA AACACGTTGA AGCTTTGCCA 
TTATATGAAA GAGCATTAAA GATTTATGAA GATAGCCTGG GTCGGATGCA TCCTCGAGTT 
GGAGAAACAC TGAAAAATTT AGCTGTGCTT AGCTATGAAG GAGGAGATTT TGAAAAAGCT 
GCTGAATTAT ACAAAAGGGC AATGGAAATA AAAGAAGCAG AAACATCACT CTTGGGTGGA 
AAAGCTCCTT CACGCCATTC ATCAAGTGGA GACACGTTTA GCTTAAAAAC AGCTCATTCT 
CCTAATGTTT TCCTTCAGCA AGGACAAAGG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NPHP3 ( NM_153240.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_694972.3 Homo sapiens nephrocystin 3 (NPHP3), mRNA.

Price & Availability↑

CloneID	OHu20735
Clone ID Related Accession (Same CDS sequence)	NM_153240.5 , NM_153240.4
Accession Version	NM_153240.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	nephrocystin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC055732.16, DB114822.1, AY257864.1 and EB387619.1. This sequence is a reference standard in the RefSeqGene project. On Feb 8, 2011 this sequence version replaced NM_153240.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.95967.1, AY257864.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGACCG CCTCGTCGCT CGTGAGCCCC GCGGGCGGGG AAGTGATCGA GGACACGTAC 
GGGGCGGGCG GCGGCGAGGC CTGCGAGATC CCGGTGGAGG TGAAGCCCAA GGCCCGCCTG 
CTGCGCAACT CGTTCCGCCG AGGCGCGGGG GCGGCAGCAG GGGCCGGGCC CGGGTCGCTG 
CCCCGCGGGG TGGGCGCGGG CGGGCTGCTG GGGGCCAGCT TCAAGTCCAC TGGCTCGTCG 
GTGCCAGAGC TGGAGTACGC GGCGGCCGAG TACGAGCGGC TCAGGAAGGA GTACGAGATC 
TTTCGCGTCA GCAAGAACCA GGAGTTGTTG TCCATGGGCC GCCGCGAGGC CAAGCTGGAC 
ACGGAGAACA AGCGGCTGCG GGCCGAACTG CAGGCACTTC AAAAAACGTA TCAGAAGATA 
CTTCGAGAAA AAGAAAGTGC TTTAGAAGCG AAATACCAAG CAATGGAGAG AGCAGCAACA 
TTTGAACATG ACAGAGATAA AGTTAAAAGG CAATTCAAGA TTTTTAGGGA GACCAAAGAA 
AATGAAATTC AGGACTTACT GAGGGCCAAG AGGGAGTTGG AGAGCAAACT TCAGAGGCTA 
CAGGCTCAGG GTATCCAAGT ATTTGATCCT GGGGAGTCTG ATTCAGATGA CAACTGTACA 
GATGTCACTG CTGCTGGAAC CCAATGTGAA TATTGGACTG GCGGAGCCTT GGGAAGTGAA 
CCTTCCATAG GAAGCATGAT CCAGCTTCAG CAGTCCTTCA GAGGCCCTGA GTTTGCCCAT 
AGTTCTATAG ATGTGGAAGG ACCCTTTGCA AATGTTAATA GAGATGACTG GGATATTGCT 
GTAGCTAGTT TATTACAAGT TACTCCTCTG TTTTCACATT CTCTGTGGAG TAACACTGTC 
AGATGTTACC TCATTTATAC AGATGAAACC CAGCCTGAGA TGGATCTTTT CCTTAAGGAC 
TATTCACCTA AACTTAAGAG AATGTGCGAG ACAATGGGAT ATTTTTTCCA TGCTGTTTAT 
TTTCCAATAG ATGTTGAAAA TCAATACCTC ACTGTAAGAA AATGGGAAAT TGAGAAAAGT 
TCTTTAGTTA TTTTATTTAT TCACTTAACA TTACCAAGCC TTTTATTGGA AGACTGTGAA 
GAAGCTTTTC TGAAAAACCC TGAAGGAAAA CCTCGATTAA TCTTTCATCG TTTGGAAGAT 
GGAAAAGTCA GTTCTGACTC TGTCCAGCAA TTGATTGATC AAGTTTCTAA TCTAAACAAG 
ACCAGCAAAG CCAAGATCAT TGATCACTCA GGAGATCCTG CAGAAGGAGT ATATAAAACT 
TATATTTGTG TAGAAAAGAT TATTAAACAG GACATACTGG GTTTTGAGAA CACAGACTTG 
GAGACTAAGG ATTTGGGCAG TGAGGATTCC ATTCCAGAAG AAGATGATTT TGGTGATGTT 
CTGTGGGACA TACATGATGA ACAAGAGCAA ATGGAAACTT TTCAGCAGGC TTCTAATTCA 
GCCCATGAGT TGGGATTTGA GAAATATTAC CAACGCCTTA ATGATCTAGT GGCAGCACCA 
GCCCCGATTC CACCTCTTCT CGTGTCTGGA GGACCAGGTT CTGGGAAGTC TCTTCTTTTA 
TCAAAGTGGA TTCAATTACA ACAGAAGAAT TCCCCCAACA CACTGATTCT TTCCCATTTT 
GTGGGAAGGC CCATGTCAAC CAGCTCAGAG TCCTCCTTGA TTATTAAACG ACTAACTCTA 
AAGTTGATGC AGCACTCTTG GTCAGTCTCT GCTCTGACAC TGGATCCTGC TAAGCTTCTG 
GAAGAATTTC CACGTTGGCT GGAAAAACTC TCTGCTCGTC ATCAAGGCAG CATCATCATC 
GTTATTGATT CTATAGATCA AGTTCAGCAA GTTGAAAAAC ACATGAAATG GCTGATAGAT 
CCACTGCCAG TGAATGTAAG AGTAATTGTT TCTGTGAATG TAGAAACATG CCCTCCAGCA 
TGGAGGTTGT GGCCTACACT TCATCTTGAT CCCTTAAGTC CAAAAGATGC AAAATCTATT 
ATAATTGCAG AATGCCACTC TGTAGACATT AAATTGAGTA AAGAGCAGGA GAAGAAGCTA 
GAACGACACT GTCGTTCTGC TACAACCTGC AATGCCCTTT ATGTCACCCT TTTCGGCAAA 
ATGATCGCGC GTGCTGGGAG AGCAGGCAAT TTAGATAAAA TCCTTCATCA GTGTTTCCAG 
TGTCAAGATA CTCTTTCATT ATATAGACTT GTTCTGCACT CTATCCGGGA GTCCATGGCA 
AATGATGTGG ATAAAGAGCT AATGAAGCAG ATCCTCTGCC TTGTCAATGT TAGTCACAAT 
GGTGTGAGTG AATCAGAACT GATGGAACTC TATCCTGAGA TGTCCTGGAC TTTCTTGACC 
TCCCTTATTC ACAGTTTATA CAAAATGTGT TTGTTGACTT ATGGATGTGG CTTGCTTAGG 
TTTCAACATC TGCAGGCTTG GGAAACAGTG AGATTGGAGT ACCTGGAAGG CCCCACTGTT 
ACTTCTTCAT ACAGGCAAAA GCTAATCAAC TATTTCACCT TGCAGCTAAG TCAGGACAGA 
GTGACTTGGA GAAGTGCAGA TGAACTCCCG TGGCTTTTTC AGCAGCAGGG AAGTAAACAG 
AAGCTGCATG ATTGCCTTCT TAATCTCTTT GTGTCTCAAA ACCTTTATAA AAGGGGACAC 
TTTGCTGAGT TGCTGAGTTA TTGGCAGTTT GTTGGCAAAG ACAAAAGTGC AATGGCAACA 
GAATACTTCG ATTCATTGAA GCAGTATGAG AAAAACTGCG AAGGCGAGGA CAACATGAGT 
TGCTTAGCTG ATCTTTATGA AACCTTGGGG CGATTTCTCA AGGATCTAGG CCTTCTCAGT 
CAGGCCATAG TACCTTTGCA GAGGTCTTTA GAGATTCGAG AAACAGCTTT AGATCCCGAT 
CACCCAAGAG TAGCCCAGTC CCTCCACCAA CTAGCAAGTG TATACGTGCA GTGGAAGAAG 
TTTGGCAATG CAGAACAACT GTATAAACAG GCGTTGGAAA TCTCAGAAAA TGCTTATGGT 
GCGGACCATC CATATACTGC TCGTGAACTT GAAGCACTTG CAACTTTGTA CCAGAAACAA 
AATAAATATG AACAAGCTGA ACATTTTAGG AAAAAATCCT TTAAAATTCA TCAGAAAGCT 
ATAAAGAAAA AAGGCAACTT GTACGGATTT GCCCTTTTAC GTAGACGGGC TTTACAGTTA 
GAAGAGCTTA CATTAGGTAA GGACACACCT GATAATGCTC GGACCCTCAA TGAACTGGGT 
GTTCTCTACT ATCTTCAAAA TAACCTGGAA ACAGCTGACC AGTTTCTGAA GCGTTCCTTA 
GAAATGAGGG AGCGAGTTCT AGGACCAGAT CACCCTGACT GTGCTCAGTC TTTGAATAAT 
CTGGCAGCTC TATGCAATGA AAAGAAACAG TATGATAAAG CAGAAGAACT TTATGAAAGA 
GCTTTAGATA TTCGGAGACG TGCATTAGCT CCTGATCACC CTTCTTTGGC ATATACGGTG 
AAGCATCTTG CCATCTTGTA TAAGAAAATG GGGAAACTTG ACAAAGCTGT ACCTTTGTAT 
GAATTGGCTG TTGAAATTCG ACAGAAATCT TTTGGCCCAA AGCACCCTAG TGTAGCTACT 
GCCTTGGTGA ACTTAGCTGT TCTTTATAGC CAAATGAAAA AACACGTTGA AGCTTTGCCA 
TTATATGAAA GAGCATTAAA GATTTATGAA GATAGCCTGG GTCGGATGCA TCCTCGAGTT 
GGAGAAACAC TGAAAAATTT AGCTGTGCTT AGCTATGAAG GAGGAGATTT TGAAAAAGCT 
GCTGAATTAT ACAAAAGGGC AATGGAAATA AAAGAAGCAG AAACATCACT CTTGGGTGGA 
AAAGCTCCTT CACGCCATTC ATCAAGTGGA GACACGTTTA GCTTAAAAAC AGCTCATTCT 
CCTAATGTTT TCCTTCAGCA AGGACAAAGG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694972.3
CDS	105..4097
Translation	MGTASSLVSPAGGEVIEDTYGAGGGEACEIPVEVKPKARLLRNSFRRGAGAAAGAGPGSLPRGVGAGGLLGASFKSTGSSVPELEYAAAEYERLRKEYEIFRVSKNQELLSMGRREAKLDTENKRLRAELQALQKTYQKILREKESALEAKYQAMERAATFEHDRDKVKRQFKIFRETKENEIQDLLRAKRELESKLQRLQAQGIQVFDPGESDSDDNCTDVTAAGTQCEYWTGGALGSEPSIGSMIQLQQSFRGPEFAHSSIDVEGPFANVNRDDWDIAVASLLQVTPLFSHSLWSNTVRCYLIYTDETQPEMDLFLKDYSPKLKRMCETMGYFFHAVYFPIDVENQYLTVRKWEIEKSSLVILFIHLTLPSLLLEDCEEAFLKNPEGKPRLIFHRLEDGKVSSDSVQQLIDQVSNLNKTSKAKIIDHSGDPAEGVYKTYICVEKIIKQDILGFENTDLETKDLGSEDSIPEEDDFGDVLWDIHDEQEQMETFQQASNSAHELGFEKYYQRLNDLVAAPAPIPPLLVSGGPGSGKSLLLSKWIQLQQKNSPNTLILSHFVGRPMSTSSESSLIIKRLTLKLMQHSWSVSALTLDPAKLLEEFPRWLEKLSARHQGSIIIVIDSIDQVQQVEKHMKWLIDPLPVNVRVIVSVNVETCPPAWRLWPTLHLDPLSPKDAKSIIIAECHSVDIKLSKEQEKKLERHCRSATTCNALYVTLFGKMIARAGRAGNLDKILHQCFQCQDTLSLYRLVLHSIRESMANDVDKELMKQILCLVNVSHNGVSESELMELYPEMSWTFLTSLIHSLYKMCLLTYGCGLLRFQHLQAWETVRLEYLEGPTVTSSYRQKLINYFTLQLSQDRVTWRSADELPWLFQQQGSKQKLHDCLLNLFVSQNLYKRGHFAELLSYWQFVGKDKSAMATEYFDSLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETSLLGGKAPSRHSSSGDTFSLKTAHSPNVFLQQGQR

Target ORF information:

RefSeq Version	NM_153240.4
Organism	Homo sapiens(human)
Definition	Homo sapiens nephrocystin 3 (NPHP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153240.4

ORF Insert Sequence:

ATGGGGACCG CCTCGTCGCT CGTGAGCCCC GCGGGCGGGG AAGTGATCGA GGACACGTAC 
GGGGCGGGCG GCGGCGAGGC CTGCGAGATC CCGGTGGAGG TGAAGCCCAA GGCCCGCCTG 
CTGCGCAACT CGTTCCGCCG AGGCGCGGGG GCGGCAGCAG GGGCCGGGCC CGGGTCGCTG 
CCCCGCGGGG TGGGCGCGGG CGGGCTGCTG GGGGCCAGCT TCAAGTCCAC TGGCTCGTCG 
GTGCCAGAGC TGGAGTACGC GGCGGCCGAG TACGAGCGGC TCAGGAAGGA GTACGAGATC 
TTTCGCGTCA GCAAGAACCA GGAGTTGTTG TCCATGGGCC GCCGCGAGGC CAAGCTGGAC 
ACGGAGAACA AGCGGCTGCG GGCCGAACTG CAGGCACTTC AAAAAACGTA TCAGAAGATA 
CTTCGAGAAA AAGAAAGTGC TTTAGAAGCG AAATACCAAG CAATGGAGAG AGCAGCAACA 
TTTGAACATG ACAGAGATAA AGTTAAAAGG CAATTCAAGA TTTTTAGGGA GACCAAAGAA 
AATGAAATTC AGGACTTACT GAGGGCCAAG AGGGAGTTGG AGAGCAAACT TCAGAGGCTA 
CAGGCTCAGG GTATCCAAGT ATTTGATCCT GGGGAGTCTG ATTCAGATGA CAACTGTACA 
GATGTCACTG CTGCTGGAAC CCAATGTGAA TATTGGACTG GCGGAGCCTT GGGAAGTGAA 
CCTTCCATAG GAAGCATGAT CCAGCTTCAG CAGTCCTTCA GAGGCCCTGA GTTTGCCCAT 
AGTTCTATAG ATGTGGAAGG ACCCTTTGCA AATGTTAATA GAGATGACTG GGATATTGCT 
GTAGCTAGTT TATTACAAGT TACTCCTCTG TTTTCACATT CTCTGTGGAG TAACACTGTC 
AGATGTTACC TCATTTATAC AGATGAAACC CAGCCTGAGA TGGATCTTTT CCTTAAGGAC 
TATTCACCTA AACTTAAGAG AATGTGCGAG ACAATGGGAT ATTTTTTCCA TGCTGTTTAT 
TTTCCAATAG ATGTTGAAAA TCAATACCTC ACTGTAAGAA AATGGGAAAT TGAGAAAAGT 
TCTTTAGTTA TTTTATTTAT TCACTTAACA TTACCAAGCC TTTTATTGGA AGACTGTGAA 
GAAGCTTTTC TGAAAAACCC TGAAGGAAAA CCTCGATTAA TCTTTCATCG TTTGGAAGAT 
GGAAAAGTCA GTTCTGACTC TGTCCAGCAA TTGATTGATC AAGTTTCTAA TCTAAACAAG 
ACCAGCAAAG CCAAGATCAT TGATCACTCA GGAGATCCTG CAGAAGGAGT ATATAAAACT 
TATATTTGTG TAGAAAAGAT TATTAAACAG GACATACTGG GTTTTGAGAA CACAGACTTG 
GAGACTAAGG ATTTGGGCAG TGAGGATTCC ATTCCAGAAG AAGATGATTT TGGTGATGTT 
CTGTGGGACA TACATGATGA ACAAGAGCAA ATGGAAACTT TTCAGCAGGC TTCTAATTCA 
GCCCATGAGT TGGGATTTGA GAAATATTAC CAACGCCTTA ATGATCTAGT GGCAGCACCA 
GCCCCGATTC CACCTCTTCT CGTGTCTGGA GGACCAGGTT CTGGGAAGTC TCTTCTTTTA 
TCAAAGTGGA TTCAATTACA ACAGAAGAAT TCCCCCAACA CACTGATTCT TTCCCATTTT 
GTGGGAAGGC CCATGTCAAC CAGCTCAGAG TCCTCCTTGA TTATTAAACG ACTAACTCTA 
AAGTTGATGC AGCACTCTTG GTCAGTCTCT GCTCTGACAC TGGATCCTGC TAAGCTTCTG 
GAAGAATTTC CACGTTGGCT GGAAAAACTC TCTGCTCGTC ATCAAGGCAG CATCATCATC 
GTTATTGATT CTATAGATCA AGTTCAGCAA GTTGAAAAAC ACATGAAATG GCTGATAGAT 
CCACTGCCAG TGAATGTAAG AGTAATTGTT TCTGTGAATG TAGAAACATG CCCTCCAGCA 
TGGAGGTTGT GGCCTACACT TCATCTTGAT CCCTTAAGTC CAAAAGATGC AAAATCTATT 
ATAATTGCAG AATGCCACTC TGTAGACATT AAATTGAGTA AAGAGCAGGA GAAGAAGCTA 
GAACGACACT GTCGTTCTGC TACAACCTGC AATGCCCTTT ATGTCACCCT TTTCGGCAAA 
ATGATCGCGC GTGCTGGGAG AGCAGGCAAT TTAGATAAAA TCCTTCATCA GTGTTTCCAG 
TGTCAAGATA CTCTTTCATT ATATAGACTT GTTCTGCACT CTATCCGGGA GTCCATGGCA 
AATGATGTGG ATAAAGAGCT AATGAAGCAG ATCCTCTGCC TTGTCAATGT TAGTCACAAT 
GGTGTGAGTG AATCAGAACT GATGGAACTC TATCCTGAGA TGTCCTGGAC TTTCTTGACC 
TCCCTTATTC ACAGTTTATA CAAAATGTGT TTGTTGACTT ATGGATGTGG CTTGCTTAGG 
TTTCAACATC TGCAGGCTTG GGAAACAGTG AGATTGGAGT ACCTGGAAGG CCCCACTGTT 
ACTTCTTCAT ACAGGCAAAA GCTAATCAAC TATTTCACCT TGCAGCTAAG TCAGGACAGA 
GTGACTTGGA GAAGTGCAGA TGAACTCCCG TGGCTTTTTC AGCAGCAGGG AAGTAAACAG 
AAGCTGCATG ATTGCCTTCT TAATCTCTTT GTGTCTCAAA ACCTTTATAA AAGGGGACAC 
TTTGCTGAGT TGCTGAGTTA TTGGCAGTTT GTTGGCAAAG ACAAAAGTGC AATGGCAACA 
GAATACTTCG ATTCATTGAA GCAGTATGAG AAAAACTGCG AAGGCGAGGA CAACATGAGT 
TGCTTAGCTG ATCTTTATGA AACCTTGGGG CGATTTCTCA AGGATCTAGG CCTTCTCAGT 
CAGGCCATAG TACCTTTGCA GAGGTCTTTA GAGATTCGAG AAACAGCTTT AGATCCCGAT 
CACCCAAGAG TAGCCCAGTC CCTCCACCAA CTAGCAAGTG TATACGTGCA GTGGAAGAAG 
TTTGGCAATG CAGAACAACT GTATAAACAG GCGTTGGAAA TCTCAGAAAA TGCTTATGGT 
GCGGACCATC CATATACTGC TCGTGAACTT GAAGCACTTG CAACTTTGTA CCAGAAACAA 
AATAAATATG AACAAGCTGA ACATTTTAGG AAAAAATCCT TTAAAATTCA TCAGAAAGCT 
ATAAAGAAAA AAGGCAACTT GTACGGATTT GCCCTTTTAC GTAGACGGGC TTTACAGTTA 
GAAGAGCTTA CATTAGGTAA GGACACACCT GATAATGCTC GGACCCTCAA TGAACTGGGT 
GTTCTCTACT ATCTTCAAAA TAACCTGGAA ACAGCTGACC AGTTTCTGAA GCGTTCCTTA 
GAAATGAGGG AGCGAGTTCT AGGACCAGAT CACCCTGACT GTGCTCAGTC TTTGAATAAT 
CTGGCAGCTC TATGCAATGA AAAGAAACAG TATGATAAAG CAGAAGAACT TTATGAAAGA 
GCTTTAGATA TTCGGAGACG TGCATTAGCT CCTGATCACC CTTCTTTGGC ATATACGGTG 
AAGCATCTTG CCATCTTGTA TAAGAAAATG GGGAAACTTG ACAAAGCTGT ACCTTTGTAT 
GAATTGGCTG TTGAAATTCG ACAGAAATCT TTTGGCCCAA AGCACCCTAG TGTAGCTACT 
GCCTTGGTGA ACTTAGCTGT TCTTTATAGC CAAATGAAAA AACACGTTGA AGCTTTGCCA 
TTATATGAAA GAGCATTAAA GATTTATGAA GATAGCCTGG GTCGGATGCA TCCTCGAGTT 
GGAGAAACAC TGAAAAATTT AGCTGTGCTT AGCTATGAAG GAGGAGATTT TGAAAAAGCT 
GCTGAATTAT ACAAAAGGGC AATGGAAATA AAAGAAGCAG AAACATCACT CTTGGGTGGA 
AAAGCTCCTT CACGCCATTC ATCAAGTGGA GACACGTTTA GCTTAAAAAC AGCTCATTCT 
CCTAATGTTT TCCTTCAGCA AGGACAAAGG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Homozygous mutation in the NPHP3 gene causing foetal nephronophthisis.
Nephrology (Carlton, Vic.)22(10)818-820(2017 Oct)
Abdullah U,Farooq M,Fatima A,Tauseef W,Sarwar Y,Nuri M,Tommerup N,Baig SM

A familial case of severe infantile nephronophthisis explained by oligogenic inheritance.
European journal of medical genetics60(6)321-325(2017 Jun)
Penchev V,Boueva A,Kamenarova K,Roussinov D,Tzveova R,Ivanova M,Dimitrova V,Kremensky I,Mitev V,Kaneva R,Beltcheva O

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

High mutation rate of NPHP3 in 18 Chinese infantile nephronophthisis patients.
Nephrology (Carlton, Vic.)21(3)209-16(2016 Mar)
Sun L,Tong H,Wang H,Yue Z,Liu T,Lin H,Li J,Wang C

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NPHP3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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