Gene Symbol | ABL2 |
Entrez Gene ID | 27 |
Full Name | ABL proto-oncogene 2, non-receptor tyrosine kinase |
Synonyms | ABLL,ARG |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]. |
Disorder MIM: | |
Disorder Html: | Leukemia, acute myeloid, with eosinophilia (1) |