RNF11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNF11
Entrez Gene ID	26994
Full Name	ring finger protein 11
Synonyms	CGI-123,SID1669
General protein information	Preferred Names ring finger protein 11 Names RING finger protein 11
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p32.3
Summary	The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008].
Disorder MIM:	612598

mRNA and Protein(s)

mRNA	Protein	Name
NM_014372.5	NP_055187.1	RING finger protein 11
NM_014372.4	NP_055187.1	RING finger protein 11

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RNF11	NP_001238877.1
Danio rerio (zebrafish)	rnf11b	NP_001121880.1
Drosophila melanogaster (fruit fly)	CG32850	NP_001259053.1
Xenopus tropicalis (tropical clawed frog)	rnf11	NP_001016437.1
Homo sapiens (human)	RNF11	NP_055187.1
Caenorhabditis elegans (roundworm)	CELE_C01G6.4	NP_495976.1
Bos taurus (cattle)	RNF11	NP_001071421.1
Mus musculus (house mouse)	Rnf11	NP_038904.1
Rattus norvegicus (Norway rat)	Rnf11l1	NP_001258153.1
	RNF11	XP_001111014.1
Gallus gallus (chicken)	RNF11	NP_001006540.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor ? signaling.
Malonis RJ, Fu W, Jelcic MJ, Thompson M, Canter BS, Tsikitis M, Esteva FJ, S?nchez I
The Journal of biological chemistry292(18)7435-7451(2017 05)

The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.
Scharaw S, Iskar M, Ori A, Boncompain G, Laketa V, Poser I, Lundberg E, Perez F, Beck M, Bork P, Pepperkok R
The Journal of cell biology215(4)543-558(2016 Nov)

RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch.
Santonico E, Mattioni A, Panni S, Belleudi F, Mattei M, Torrisi MR, Cesareni G, Castagnoli L
Oncogene34(26)3377-90(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggest for the first time that the choice of binding partners for SMURF2 can sustain or repress TGFbeta signaling, and RNF11 may promote TGFbeta-induced cell migration.
Title: RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor ? signaling.

Up-regulation of COPII components requires the transcriptional regulator RNF11, which localizes to early endosomes and appears additionally in the cell nucleus upon continuous EGF stimulation.
Title: The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.

RNF11 is at the center of a finally regulated system where it acts both as an adaptor and a modulator of itch-mediated control of ubiquitination events underlying membrane traffic.
Title: RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch.

Our data exemplifies the relevance of RNF11 and persistent NF-kappaB activation in Parkinson's disease
Title: NF-?B activity is inversely correlated to RNF11 expression in Parkinson's disease.

RNF11 functions together with TAX1BP1 to restrict antiviral signaling and IFN-beta production.
Title: RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling.

The following RNF11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNF11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29196	NM_014372.5 Latest version!	Homo sapiens ring finger protein 11 (RNF11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29196	NM_014372.4	Homo sapiens ring finger protein 11 (RNF11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNF11 ( NM_014372.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055187.1 Homo sapiens ring finger protein 11 (RNF11), mRNA.

Price & Availability↑

CloneID	OHu29196
Clone ID Related Accession (Same CDS sequence)	NM_014372.5 , NM_014372.4
Accession Version	NM_014372.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	RING finger protein 11
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB265274.1, BC047654.1, BC036670.1, BC020964.2, DB564333.1 and AA224090.1. On Nov 23, 2018 this sequence version replaced NM_014372.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.213058.1, SRR1660803.151881.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000242719.4/ ENSP00000242719.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGAACT GCCTCAAATC CCCCACCTCG GATGACATCT CCCTGCTTCA CGAGTCTCAG 
TCCGACCGGG CTAGCTTTGG CGAGGGGACG GAGCCGGATC AGGAGCCGCC GCCGCCATAT 
CAGGAACAAG TTCCAGTTCC AGTCTACCAC CCAACACCTA GCCAGACTCG GCTAGCAACT 
CAGCTGACTG AAGAGGAACA AATTAGGATA GCTCAAAGAA TAGGTCTTAT ACAACATCTG 
CCTAAAGGAG TTTATGACCC TGGAAGAGAT GGATCAGAAA AAAAGATCCG GGAGTGTGTG 
ATCTGTATGA TGGACTTTGT TTATGGGGAC CCAATTCGAT TTCTGCCGTG CATGCACATC 
TATCACCTGG ACTGTATAGA TGACTGGTTG ATGAGATCCT TCACGTGCCC CTCCTGCATG 
GAGCCAGTTG ATGCAGCACT GCTTTCATCC TATGAGACTA ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055187.1
CDS	485..949
Translation	MGNCLKSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQVPVPVYHPTPSQTRLATQLTEEEQIRIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN

Target ORF information:

RefSeq Version	NM_014372.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 11 (RNF11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014372.5

ORF Insert Sequence:

ATGGGGAACT GCCTCAAATC CCCCACCTCG GATGACATCT CCCTGCTTCA CGAGTCTCAG 
TCCGACCGGG CTAGCTTTGG CGAGGGGACG GAGCCGGATC AGGAGCCGCC GCCGCCATAT 
CAGGAACAAG TTCCAGTTCC AGTCTACCAC CCAACACCTA GCCAGACTCG GCTAGCAACT 
CAGCTGACTG AAGAGGAACA AATTAGGATA GCTCAAAGAA TAGGTCTTAT ACAACATCTG 
CCTAAAGGAG TTTATGACCC TGGAAGAGAT GGATCAGAAA AAAAGATCCG GGAGTGTGTG 
ATCTGTATGA TGGACTTTGT TTATGGGGAC CCAATTCGAT TTCTGCCGTG CATGCACATC 
TATCACCTGG ACTGTATAGA TGACTGGTTG ATGAGATCCT TCACGTGCCC CTCCTGCATG 
GAGCCAGTTG ATGCAGCACT GCTTTCATCC TATGAGACTA ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNF11 ( NM_014372.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055187.1 Homo sapiens ring finger protein 11 (RNF11), mRNA.

Price & Availability↑

CloneID	OHu29196
Clone ID Related Accession (Same CDS sequence)	NM_014372.5 , NM_014372.4
Accession Version	NM_014372.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-26
Organism	Homo sapiens(human)
Product	RING finger protein 11
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB265274.1, BC047654.1, BC036670.1, BC020964.2, DB564333.1 and AA224090.1. On Aug 31, 2007 this sequence version replaced NM_014372.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.213058.1, SRR1660803.151881.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGAACT GCCTCAAATC CCCCACCTCG GATGACATCT CCCTGCTTCA CGAGTCTCAG 
TCCGACCGGG CTAGCTTTGG CGAGGGGACG GAGCCGGATC AGGAGCCGCC GCCGCCATAT 
CAGGAACAAG TTCCAGTTCC AGTCTACCAC CCAACACCTA GCCAGACTCG GCTAGCAACT 
CAGCTGACTG AAGAGGAACA AATTAGGATA GCTCAAAGAA TAGGTCTTAT ACAACATCTG 
CCTAAAGGAG TTTATGACCC TGGAAGAGAT GGATCAGAAA AAAAGATCCG GGAGTGTGTG 
ATCTGTATGA TGGACTTTGT TTATGGGGAC CCAATTCGAT TTCTGCCGTG CATGCACATC 
TATCACCTGG ACTGTATAGA TGACTGGTTG ATGAGATCCT TCACGTGCCC CTCCTGCATG 
GAGCCAGTTG ATGCAGCACT GCTTTCATCC TATGAGACTA ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055187.1
CDS	485..949
Translation	MGNCLKSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQVPVPVYHPTPSQTRLATQLTEEEQIRIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN

Target ORF information:

RefSeq Version	NM_014372.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ring finger protein 11 (RNF11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014372.4

ORF Insert Sequence:

ATGGGGAACT GCCTCAAATC CCCCACCTCG GATGACATCT CCCTGCTTCA CGAGTCTCAG 
TCCGACCGGG CTAGCTTTGG CGAGGGGACG GAGCCGGATC AGGAGCCGCC GCCGCCATAT 
CAGGAACAAG TTCCAGTTCC AGTCTACCAC CCAACACCTA GCCAGACTCG GCTAGCAACT 
CAGCTGACTG AAGAGGAACA AATTAGGATA GCTCAAAGAA TAGGTCTTAT ACAACATCTG 
CCTAAAGGAG TTTATGACCC TGGAAGAGAT GGATCAGAAA AAAAGATCCG GGAGTGTGTG 
ATCTGTATGA TGGACTTTGT TTATGGGGAC CCAATTCGAT TTCTGCCGTG CATGCACATC 
TATCACCTGG ACTGTATAGA TGACTGGTTG ATGAGATCCT TCACGTGCCC CTCCTGCATG 
GAGCCAGTTG ATGCAGCACT GCTTTCATCC TATGAGACTA ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor ? signaling.
The Journal of biological chemistry292(18)7435-7451(2017 05)
Malonis RJ,Fu W,Jelcic MJ,Thompson M,Canter BS,Tsikitis M,Esteva FJ,S?nchez I

The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.
The Journal of cell biology215(4)543-558(2016 Nov)
Scharaw S,Iskar M,Ori A,Boncompain G,Laketa V,Poser I,Lundberg E,Perez F,Beck M,Bork P,Pepperkok R

RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch.
Oncogene34(26)3377-90(2015 Jun)
Santonico E,Mattioni A,Panni S,Belleudi F,Mattei M,Torrisi MR,Cesareni G,Castagnoli L

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RNF11 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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