GIP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GIP
Entrez Gene ID	2695
Full Name	gastric inhibitory polypeptide
General protein information	Preferred Names gastric inhibitory polypeptide Names gastric inhibitory polypeptide glucose-dependent insulinotropic polypeptide incretin hormone
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.32
Summary	This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008].
Disorder MIM:	137240

mRNA and Protein(s)

mRNA	Protein	Name
NM_004123.2	NP_004114.1	gastric inhibitory polypeptide preproprotein
NM_004123.3	NP_004114.1	gastric inhibitory polypeptide preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	GIP	NP_004114.1
	GIP	XP_001091383.1
Canis lupus familiaris (dog)	GIP	XP_003639320.2
Bos taurus (cattle)	GIP	NP_001160077.1
Pan troglodytes (chimpanzee)	GIP	XP_001172671.1
Mus musculus (house mouse)	Gip	NP_032145.2
Rattus norvegicus (Norway rat)	Gip	NP_062604.1

Gene Ontology
Bibliography

Related articles in PubMed

The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor.
Asmar M, Asmar A, Simonsen L, Gasbjerg LS, Sparre-Ulrich AH, Rosenkilde MM, Hartmann B, Dela F, Holst JJ, B?low J
Diabetes66(9)2363-2371(2017 09)

Incretin secretion in humans is under the influence of cannabinoid receptors.
Chia CW, Carlson OD, Liu DD, Gonz?lez-Mariscal I, Santa-Cruz Calvo S, Egan JM
American journal of physiology. Endocrinology and metabolism313(3)E359-E366(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GIP and PP plasma concentrations are lower in pancreatic cancer irrespective of the degree of glucose intolerance as compared to Type 2 diabetic patients and healthy controls.
Title: Lower plasma levels of glucose-dependent insulinotropic peptide (GIP) and pancreatic polypeptide (PP) in patients with ductal adenocarcinoma of the pancreas and their relation to the presence of impaired glucoregulation and weight loss.

The ability of a truncated form of GIP, GIP(3-30)NH2, to antagonize the physiological actions of GIP in glucose metabolism, subcutaneous abdominal adipose tissue blood flow, and lipid metabolism in humans.
Title: The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor.

Compared with the lean group, the obese group had significantly higher fasting and post-OGTT GIP levels, but similar fasting GLP-1 and significantly lower post-OGTT GLP-1 levels.
Title: Incretin secretion in humans is under the influence of cannabinoid receptors.

the stimulatory effect of IGF-1 on GIP promoter support the hypothesis of a functional growth hormone-igf-1-GIP axis
Title: The GIP/GIPR axis is functionally linked to GH-secretion increase in a significant proportion of

Evening postprandial insulin and GIP responses and insulin resistance declined by over 30% after three meals that limited daily carbohydrate intake to 30% compared to no such changes after three 60%-carbohydrate meals, an effect that was independent of pre-meal exercise.
Title: Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance.

The following GIP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GIP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10094	NM_004123.3 Latest version!	Homo sapiens gastric inhibitory polypeptide (GIP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu10094	NM_004123.2	Homo sapiens gastric inhibitory polypeptide (GIP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GIP ( NM_004123.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004114.1 Homo sapiens gastric inhibitory polypeptide (GIP), mRNA.

Price & Availability↑

CloneID	OHu10094
Clone ID Related Accession (Same CDS sequence)	NM_004123.2 , NM_004123.3
Accession Version	NM_004123.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	gastric inhibitory polypeptide preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M18185.1 and BC069100.1. On Apr 6, 2005 this sequence version replaced NM_004123.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC069100.1, M18185.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGCCA CGAAGACCTT TGCTCTGCTG CTGCTGTCCC TGTTCCTGGC AGTGGGACTA 
GGAGAGAAGA AAGAGGGTCA CTTCAGCGCT CTCCCCTCCC TGCCTGTTGG ATCTCATGCT 
AAGGTGAGCA GCCCTCAACC TCGAGGCCCC AGGTACGCGG AAGGGACTTT CATCAGTGAC 
TACAGTATTG CCATGGACAA GATTCACCAA CAAGACTTTG TGAACTGGCT GCTGGCCCAA 
AAGGGGAAGA AGAATGACTG GAAACACAAC ATCACCCAGA GGGAGGCTCG GGCGCTGGAG 
CTGGCCAGTC AAGCTAATAG GAAGGAGGAG GAGGCAGTGG AGCCACAGAG CTCCCCAGCC 
AAGAACCCCA GCGATGAAGA TTTGCTGCGG GACTTGCTGA TTCAAGAGCT GTTGGCCTGC 
TTGCTGGATC AGACAAACCT CTGCAGGCTC AGGTCTCGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004114.1
CDS	99..560
Translation	MVATKTFALLLLSLFLAVGLGEKKEGHFSALPSLPVGSHAKVSSPQPRGPRYAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQREARALELASQANRKEEEAVEPQSSPAKNPSDEDLLRDLLIQELLACLLDQTNLCRLRSR

Target ORF information:

RefSeq Version	NM_004123.2
Organism	Homo sapiens(human)
Definition	Homo sapiens gastric inhibitory polypeptide (GIP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004123.2

ORF Insert Sequence:

ATGGTGGCCA CGAAGACCTT TGCTCTGCTG CTGCTGTCCC TGTTCCTGGC AGTGGGACTA 
GGAGAGAAGA AAGAGGGTCA CTTCAGCGCT CTCCCCTCCC TGCCTGTTGG ATCTCATGCT 
AAGGTGAGCA GCCCTCAACC TCGAGGCCCC AGGTACGCGG AAGGGACTTT CATCAGTGAC 
TACAGTATTG CCATGGACAA GATTCACCAA CAAGACTTTG TGAACTGGCT GCTGGCCCAA 
AAGGGGAAGA AGAATGACTG GAAACACAAC ATCACCCAGA GGGAGGCTCG GGCGCTGGAG 
CTGGCCAGTC AAGCTAATAG GAAGGAGGAG GAGGCAGTGG AGCCACAGAG CTCCCCAGCC 
AAGAACCCCA GCGATGAAGA TTTGCTGCGG GACTTGCTGA TTCAAGAGCT GTTGGCCTGC 
TTGCTGGATC AGACAAACCT CTGCAGGCTC AGGTCTCGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GIP ( NM_004123.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004114.1 Homo sapiens gastric inhibitory polypeptide (GIP), mRNA.

Price & Availability↑

CloneID	OHu10094
Clone ID Related Accession (Same CDS sequence)	NM_004123.2 , NM_004123.3
Accession Version	NM_004123.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	gastric inhibitory polypeptide preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091133.11, M18185.1 and BC069100.1. On Nov 23, 2018 this sequence version replaced NM_004123.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279836.3413.1, BC069100.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000357424.2/ ENSP00000350005.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGGCCA CGAAGACCTT TGCTCTGCTG CTGCTGTCCC TGTTCCTGGC AGTGGGACTA 
GGAGAGAAGA AAGAGGGTCA CTTCAGCGCT CTCCCCTCCC TGCCTGTTGG ATCTCATGCT 
AAGGTGAGCA GCCCTCAACC TCGAGGCCCC AGGTACGCGG AAGGGACTTT CATCAGTGAC 
TACAGTATTG CCATGGACAA GATTCACCAA CAAGACTTTG TGAACTGGCT GCTGGCCCAA 
AAGGGGAAGA AGAATGACTG GAAACACAAC ATCACCCAGA GGGAGGCTCG GGCGCTGGAG 
CTGGCCAGTC AAGCTAATAG GAAGGAGGAG GAGGCAGTGG AGCCACAGAG CTCCCCAGCC 
AAGAACCCCA GCGATGAAGA TTTGCTGCGG GACTTGCTGA TTCAAGAGCT GTTGGCCTGC 
TTGCTGGATC AGACAAACCT CTGCAGGCTC AGGTCTCGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004114.1
CDS	102..563
Translation	MVATKTFALLLLSLFLAVGLGEKKEGHFSALPSLPVGSHAKVSSPQPRGPRYAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQREARALELASQANRKEEEAVEPQSSPAKNPSDEDLLRDLLIQELLACLLDQTNLCRLRSR

Target ORF information:

RefSeq Version	NM_004123.3
Organism	Homo sapiens(human)
Definition	Homo sapiens gastric inhibitory polypeptide (GIP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004123.3

ORF Insert Sequence:

ATGGTGGCCA CGAAGACCTT TGCTCTGCTG CTGCTGTCCC TGTTCCTGGC AGTGGGACTA 
GGAGAGAAGA AAGAGGGTCA CTTCAGCGCT CTCCCCTCCC TGCCTGTTGG ATCTCATGCT 
AAGGTGAGCA GCCCTCAACC TCGAGGCCCC AGGTACGCGG AAGGGACTTT CATCAGTGAC 
TACAGTATTG CCATGGACAA GATTCACCAA CAAGACTTTG TGAACTGGCT GCTGGCCCAA 
AAGGGGAAGA AGAATGACTG GAAACACAAC ATCACCCAGA GGGAGGCTCG GGCGCTGGAG 
CTGGCCAGTC AAGCTAATAG GAAGGAGGAG GAGGCAGTGG AGCCACAGAG CTCCCCAGCC 
AAGAACCCCA GCGATGAAGA TTTGCTGCGG GACTTGCTGA TTCAAGAGCT GTTGGCCTGC 
TTGCTGGATC AGACAAACCT CTGCAGGCTC AGGTCTCGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor.
Diabetes66(9)2363-2371(2017 09)
Asmar M,Asmar A,Simonsen L,Gasbjerg LS,Sparre-Ulrich AH,Rosenkilde MM,Hartmann B,Dela F,Holst JJ,B?low J

Incretin secretion in humans is under the influence of cannabinoid receptors.
American journal of physiology. Endocrinology and metabolism313(3)E359-E366(2017 Sep)
Chia CW,Carlson OD,Liu DD,Gonz?lez-Mariscal I,Santa-Cruz Calvo S,Egan JM

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GIP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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