GH1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GH1
Entrez Gene ID	2688
Full Name	growth hormone 1
Synonyms	GH,GH-N,GHB5,GHN,IGHD1B,hGH-N
General protein information	Preferred Names growth hormone 1 Names somatotropin growth hormone B5 pituitary growth hormone
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q23.3
Summary	The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008].
Disorder MIM:	139250
Disorder Html:	Growth hormone deficiency, isolated, type IA, 262400 (3); Growth hormone deficiency, isolated, type IB, 612781 (3); Growth hormone deficiency, isolated, type II, 173100 (3); Kowarski syndrome, 262650 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000515.5	NP_000506.2	somatotropin isoform 1 precursor
NM_022560.4	NP_072054.1	somatotropin isoform 3 precursor
NM_022559.3	NP_072053.1	somatotropin isoform 2 precursor
NM_022559.4	NP_072053.1	somatotropin isoform 2 precursor
NM_022560.3	NP_072054.1	somatotropin isoform 3 precursor
NM_000515.4	NP_000506.2	somatotropin isoform 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GH1	NP_000506.2
Pan troglodytes (chimpanzee)	GH1	NP_001184093.1
	GH1	NP_001036203.1

Gene Ontology
Bibliography

Related articles in PubMed

Pathogenic and likely pathogenic genetic alterations and polymorphisms in growth hormone gene (GH1) and growth hormone releasing hormone receptor gene (GHRHR) in a cohort of isolated growth hormone deficient (IGHD) children in Sri Lanka.
Sundralingam T, Tennekoon KH, de Silva S, De Silva S, Hewage AS
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society3622-29(2017 Oct)

Growth hormone and insulin-like growth factor 1 secretions in eating disorders: Correlations with psychopathological aspects of the disorders.
Brambilla F, Santonastaso P, Caregaro L, Favaro A
Psychiatry research(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Thus, GHRH analogs of the Miami series powerfully suppress tumor growth, but have only a weak endocrine GH inhibitory activity. The suppression of tumor growth could be induced in part by the downregulation of GHRH receptors levels.
Title: Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth.

To our knowledge, c.-223C>T is the first homozygous point mutation in the GH1 promoter that leads to short stature due to idiopathic growth hormone deficiency.
Title: A homozygous point mutation in the GH1 promoter (c.-223C>T) leads to reduced GH1 expression in siblings with isolated GH deficiency (IGHD).

Our results suggest that the known protective effect of GH signaling deficiency on neoplastic tissue growth is mediated, at least partially, by regulating p53 expression
Title: Growth hormone is permissive for neoplastic colon growth.

evidence that hGH synthesis follows a diurnal rhythm and of dynamic associations of the circadian machinery with a component of a chromosomal structure of the hGH1 locus that is essential for efficient expression.
Title: Evidence for a Circadian Effect on the Reduction of Human Growth Hormone Gene Expression in Response to Excess Caloric Intake.

GH potentially negatively modulates the maturation and accumulation of lipid in adipocytes.
Title: The Effect of Growth Hormone on Lipid Accumulation or Maturation in Adipocytes.

The following GH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25686	NM_022559.4 Latest version!	Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu25687	NM_022560.4 Latest version!	Homo sapiens growth hormone 1 (GH1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu27940	NM_000515.5 Latest version!	Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu25686	NM_022559.3	Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu25687	NM_022560.3	Homo sapiens growth hormone 1 (GH1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu27940	NM_000515.4	Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GH1 ( NM_022559.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_072053.1 Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu25686
Clone ID Related Accession (Same CDS sequence)	NM_022559.3 , NM_022559.4
Accession Version	NM_022559.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 609bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	somatotropin isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV749353.1, BC062475.1 and AV753220.1. On May 21, 2014 this sequence version replaced NM_022559.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD251386.1, CD105630.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2151358, SAMEA2153307 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG 
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCCCCAG 
ACCTCCCTCT GTTTCTCAGA GTCTATTCCG ACACCCTCCA ACAGGGAGGA AACACAACAG 
AAATCCAACC TAGAGCTGCT CCGCATCTCC CTGCTGCTCA TCCAGTCGTG GCTGGAGCCC 
GTGCAGTTCC TCAGGAGTGT CTTCGCCAAC AGCCTGGTGT ACGGCGCCTC TGACAGCAAC 
GTCTATGACC TCCTAAAGGA CCTAGAGGAA GGCATCCAAA CGCTGATGGG GAGGCTGGAA 
GATGGCAGCC CCCGGACTGG GCAGATCTTC AAGCAGACCT ACAGCAAGTT CGACACAAAC 
TCACACAACG ATGACGCACT ACTCAAGAAC TACGGGCTGC TCTACTGCTT CAGGAAGGAC 
ATGGACAAGG TCGAGACATT CCTGCGCATC GTGCAGTGCC GCTCTGTGGA GGGCAGCTGT 
GGCTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072053.1
CDS	77..685
Translation	MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

Target ORF information:

RefSeq Version	NM_022559.3
Organism	Homo sapiens(human)
Definition	Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022559.3

ORF Insert Sequence:

ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG 
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCCCCAG 
ACCTCCCTCT GTTTCTCAGA GTCTATTCCG ACACCCTCCA ACAGGGAGGA AACACAACAG 
AAATCCAACC TAGAGCTGCT CCGCATCTCC CTGCTGCTCA TCCAGTCGTG GCTGGAGCCC 
GTGCAGTTCC TCAGGAGTGT CTTCGCCAAC AGCCTGGTGT ACGGCGCCTC TGACAGCAAC 
GTCTATGACC TCCTAAAGGA CCTAGAGGAA GGCATCCAAA CGCTGATGGG GAGGCTGGAA 
GATGGCAGCC CCCGGACTGG GCAGATCTTC AAGCAGACCT ACAGCAAGTT CGACACAAAC 
TCACACAACG ATGACGCACT ACTCAAGAAC TACGGGCTGC TCTACTGCTT CAGGAAGGAC 
ATGGACAAGG TCGAGACATT CCTGCGCATC GTGCAGTGCC GCTCTGTGGA GGGCAGCTGT 
GGCTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GH1 ( NM_022559.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_072053.1 Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu25686
Clone ID Related Accession (Same CDS sequence)	NM_022559.3 , NM_022559.4
Accession Version	NM_022559.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 609bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	somatotropin isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV749353.1 and BC062475.1. On May 31, 2019 this sequence version replaced NM_022559.3. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062475.1, CD106929.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2151358, SAMEA2153307 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG 
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCCCCAG 
ACCTCCCTCT GTTTCTCAGA GTCTATTCCG ACACCCTCCA ACAGGGAGGA AACACAACAG 
AAATCCAACC TAGAGCTGCT CCGCATCTCC CTGCTGCTCA TCCAGTCGTG GCTGGAGCCC 
GTGCAGTTCC TCAGGAGTGT CTTCGCCAAC AGCCTGGTGT ACGGCGCCTC TGACAGCAAC 
GTCTATGACC TCCTAAAGGA CCTAGAGGAA GGCATCCAAA CGCTGATGGG GAGGCTGGAA 
GATGGCAGCC CCCGGACTGG GCAGATCTTC AAGCAGACCT ACAGCAAGTT CGACACAAAC 
TCACACAACG ATGACGCACT ACTCAAGAAC TACGGGCTGC TCTACTGCTT CAGGAAGGAC 
ATGGACAAGG TCGAGACATT CCTGCGCATC GTGCAGTGCC GCTCTGTGGA GGGCAGCTGT 
GGCTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072053.1
CDS	64..672
Translation	MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

Target ORF information:

RefSeq Version	NM_022559.4
Organism	Homo sapiens(human)
Definition	Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022559.4

ORF Insert Sequence:

ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG 
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCCCCAG 
ACCTCCCTCT GTTTCTCAGA GTCTATTCCG ACACCCTCCA ACAGGGAGGA AACACAACAG 
AAATCCAACC TAGAGCTGCT CCGCATCTCC CTGCTGCTCA TCCAGTCGTG GCTGGAGCCC 
GTGCAGTTCC TCAGGAGTGT CTTCGCCAAC AGCCTGGTGT ACGGCGCCTC TGACAGCAAC 
GTCTATGACC TCCTAAAGGA CCTAGAGGAA GGCATCCAAA CGCTGATGGG GAGGCTGGAA 
GATGGCAGCC CCCGGACTGG GCAGATCTTC AAGCAGACCT ACAGCAAGTT CGACACAAAC 
TCACACAACG ATGACGCACT ACTCAAGAAC TACGGGCTGC TCTACTGCTT CAGGAAGGAC 
ATGGACAAGG TCGAGACATT CCTGCGCATC GTGCAGTGCC GCTCTGTGGA GGGCAGCTGT 
GGCTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GH1 ( NM_022560.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_072054.1 Homo sapiens growth hormone 1 (GH1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu25687
Clone ID Related Accession (Same CDS sequence)	NM_022560.4 , NM_022560.3
Accession Version	NM_022560.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	somatotropin isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV749353.1 and CD108592.1. On May 31, 2019 this sequence version replaced NM_022560.3. Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD106566.1, CD108592.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2151358, SAMEA2162568 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG 
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCTAGAG 
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG 
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA 
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG 
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC 
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG 
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072054.1
CDS	64..597
Translation	MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

Target ORF information:

RefSeq Version	NM_022560.4
Organism	Homo sapiens(human)
Definition	Homo sapiens growth hormone 1 (GH1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022560.4

ORF Insert Sequence:

ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG 
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCTAGAG 
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG 
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA 
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG 
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC 
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG 
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GH1 ( NM_022560.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_072054.1 Homo sapiens growth hormone 1 (GH1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu25687
Clone ID Related Accession (Same CDS sequence)	NM_022560.4 , NM_022560.3
Accession Version	NM_022560.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	somatotropin isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV749353.1, CD108592.1 and AV753220.1. On May 21, 2014 this sequence version replaced NM_022560.2. Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD108592.1, CD106566.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2151358, SAMEA2162568 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG 
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCTAGAG 
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG 
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA 
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG 
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC 
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG 
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072054.1
CDS	77..610
Translation	MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

Target ORF information:

RefSeq Version	NM_022560.3
Organism	Homo sapiens(human)
Definition	Homo sapiens growth hormone 1 (GH1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022560.3

ORF Insert Sequence:

ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG 
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TAACCTAGAG 
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG 
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA 
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG 
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC 
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG 
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GH1 ( NM_000515.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000506.2 Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27940
Clone ID Related Accession (Same CDS sequence)	NM_000515.5 , NM_000515.4
Accession Version	NM_000515.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	somatotropin isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV749353.1 and BC090045.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000515.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY613431.1, SRR5189667.317972.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000323322.10/ ENSP00000312673.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG 
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TGAAGAAGCC 
TATATCCCAA AGGAACAGAA GTATTCATTC CTGCAGAACC CCCAGACCTC CCTCTGTTTC 
TCAGAGTCTA TTCCGACACC CTCCAACAGG GAGGAAACAC AACAGAAATC CAACCTAGAG 
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG 
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA 
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG 
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC 
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG 
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000506.2
CDS	64..717
Translation	MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

Target ORF information:

RefSeq Version	NM_000515.5
Organism	Homo sapiens(human)
Definition	Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000515.5

ORF Insert Sequence:

ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG 
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TGAAGAAGCC 
TATATCCCAA AGGAACAGAA GTATTCATTC CTGCAGAACC CCCAGACCTC CCTCTGTTTC 
TCAGAGTCTA TTCCGACACC CTCCAACAGG GAGGAAACAC AACAGAAATC CAACCTAGAG 
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG 
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA 
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG 
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC 
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG 
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GH1 ( NM_000515.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000506.2 Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA.

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CloneID	OHu27940
Clone ID Related Accession (Same CDS sequence)	NM_000515.5 , NM_000515.4
Accession Version	NM_000515.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	somatotropin isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV749353.1, BC090045.1 and AV753220.1. This sequence is a reference standard in the RefSeqGene project. On May 21, 2014 this sequence version replaced NM_000515.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY613431.1, AY613432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG 
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TGAAGAAGCC 
TATATCCCAA AGGAACAGAA GTATTCATTC CTGCAGAACC CCCAGACCTC CCTCTGTTTC 
TCAGAGTCTA TTCCGACACC CTCCAACAGG GAGGAAACAC AACAGAAATC CAACCTAGAG 
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG 
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA 
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG 
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC 
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG 
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000506.2
CDS	77..730
Translation	MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

Target ORF information:

RefSeq Version	NM_000515.4
Organism	Homo sapiens(human)
Definition	Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000515.4

ORF Insert Sequence:

ATGGCTACAG GCTCCCGGAC GTCCCTGCTC CTGGCTTTTG GCCTGCTCTG CCTGCCCTGG 
CTTCAAGAGG GCAGTGCCTT CCCAACCATT CCCTTATCCA GGCTTTTTGA CAACGCTATG 
CTCCGCGCCC ATCGTCTGCA CCAGCTGGCC TTTGACACCT ACCAGGAGTT TGAAGAAGCC 
TATATCCCAA AGGAACAGAA GTATTCATTC CTGCAGAACC CCCAGACCTC CCTCTGTTTC 
TCAGAGTCTA TTCCGACACC CTCCAACAGG GAGGAAACAC AACAGAAATC CAACCTAGAG 
CTGCTCCGCA TCTCCCTGCT GCTCATCCAG TCGTGGCTGG AGCCCGTGCA GTTCCTCAGG 
AGTGTCTTCG CCAACAGCCT GGTGTACGGC GCCTCTGACA GCAACGTCTA TGACCTCCTA 
AAGGACCTAG AGGAAGGCAT CCAAACGCTG ATGGGGAGGC TGGAAGATGG CAGCCCCCGG 
ACTGGGCAGA TCTTCAAGCA GACCTACAGC AAGTTCGACA CAAACTCACA CAACGATGAC 
GCACTACTCA AGAACTACGG GCTGCTCTAC TGCTTCAGGA AGGACATGGA CAAGGTCGAG 
ACATTCCTGC GCATCGTGCA GTGCCGCTCT GTGGAGGGCA GCTGTGGCTT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pathogenic and likely pathogenic genetic alterations and polymorphisms in growth hormone gene (GH1) and growth hormone releasing hormone receptor gene (GHRHR) in a cohort of isolated growth hormone deficient (IGHD) children in Sri Lanka.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society3622-29(2017 Oct)
Sundralingam T,Tennekoon KH,de Silva S,De Silva S,Hewage AS

Growth hormone and insulin-like growth factor 1 secretions in eating disorders: Correlations with psychopathological aspects of the disorders.
Psychiatry research(2017 Jul)
Brambilla F,Santonastaso P,Caregaro L,Favaro A

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GH1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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