OPLAH cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OPLAH
Entrez Gene ID	26873
Full Name	5-oxoprolinase, ATP-hydrolysing
Synonyms	5-Opase,OPLA,OPLAHD
General protein information	Preferred Names 5-oxoprolinase, ATP-hydrolysing Names 5-oxoprolinase 5-oxo-L-prolinase pyroglutamase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.3
Summary	The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012].
Disorder MIM:	614243
Disorder Html:	5-oxoprolinase deficiency, 260005 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011516960.1	XP_011515262.1	5-oxoprolinase isoform X1
NM_017570.4	NP_060040.1	5-oxoprolinase
NM_017570.5	NP_060040.1	5-oxoprolinase

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	oplah	NP_001072883.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001606	XP_321495.3
Eremothecium gossypii	AGOS_ABR114C	NP_983061.1
Mus musculus (house mouse)	Oplah	NP_694762.1
Danio rerio (zebrafish)	si:dkey-9l5.2	NP_001186988.1
Magnaporthe oryzae (rice blast fungus)	MGG_00771	XP_003718224.1
Pan troglodytes (chimpanzee)	OPLAH	XP_003951428.1
Rattus norvegicus (Norway rat)	Oplah	NP_446356.1
Drosophila melanogaster (fruit fly)	CG4752	NP_611675.2
Caenorhabditis elegans (roundworm)	Y38F2AR.12	NP_001076725.1
Saccharomyces cerevisiae (baker's yeast)	OXP1	NP_012707.1
Kluyveromyces lactis	KLLA0C18975g	XP_453046.1
Arabidopsis thaliana (thale cress)	OXP1	NP_198599.1
Homo sapiens (human)	OPLAH	NP_060040.1
Canis lupus familiaris (dog)	OPLAH	XP_005628367.1
Bos taurus (cattle)	OPLAH	NP_001001173.1
Schizosaccharomyces pombe (fission yeast)	SPAC11D3.15	NP_592810.1
Neurospora crassa	NCU04569	XP_958668.2

Gene Ontology
Bibliography

Related articles in PubMed

Unravelling 5-oxoprolinuria (pyroglutamic aciduria) due to bi-allelic OPLAH mutations: 20 new mutations in 14 families.
Sass JO, Gemperle-Britschgi C, Tarailo-Graovac M, Patel N, Walter M, Jordanova A, Alfadhel M, Bari? I, ?oker M, Damli-Huber A, Faqeih EA, Garc?a Segarra N, Geraghty MT, J?tun BM, Kalkan U?ar S, Kriewitz M, Rauchenzauner M, Bili? K, Tournev I, Till C, Sayson B, Beumer D, Ye CX, Zhang LH, Vallance H, Alkuraya FS, van Karnebeek CD
Molecular genetics and metabolism119(1-2)44-9(2016 09)

Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies.
Li X, Ding Y, Liu Y, Ma Y, Song J, Wang Q, Yang Y
Brain & development37(10)952-9(2015 Nov)

An atlas of genetic influences on human blood metabolites.
Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, , Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenm?ller G, Spector TD, Soranzo N
Nature genetics46(6)543-550(2014 Jun)

5-Oxoprolinuria in Heterozygous Patients for 5-Oxoprolinase (OPLAH) Missense Changes.
Calpena E, Casado M, Mart?nez-Rubio D, Nascimento A, Colomer J, Gargallo E, Garc?a-Cazorla A, Palau F, Artuch R, Espin?s C
JIMD reports7123-8(2013)

Human metabolic individuality in biomedical and pharmaceutical research.
Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, W?gele B, Altmaier E, , Deloukas P, Erdmann J, Grundberg E, Hammond CJ, de Angelis MH, Kastenm?ller G, K?ttgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes HW, Milburn MV, Prehn C, Raffler J, Ried JS, R?misch-Margl W, Samani NJ, Small KS, Wichmann HE, Zhai G, Illig T, Spector TD, Adamski J, Soranzo N, Gieger C
Nature477(7362)54-60(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

An autosomal recessive mode of inheritance for 5-oxoprolinase deficiency is further supported by the identification of a single mutation in all 9/14 parent sample sets investigated (except for the father of one patient whose result suggests homozygosity), and the absence of 5-oxoprolinuria in all tested heterozygotes
Title: Unravelling 5-oxoprolinuria (pyroglutamic aciduria) due to bi-allelic OPLAH mutations: 20 new mutations in 14 families.

In this study, clinical, biochemical, and genetic aspects of five Chinese 5-oxoprolinuria patients with OPLAH or GSS gene mutations were investigated.
Title: Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies.

the cause of cellular ATP depletion in nephrotic cystinosis may be the futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase
Title: A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?

The following OPLAH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OPLAH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28255	NM_017570.5 Latest version!	Homo sapiens 5-oxoprolinase, ATP-hydrolysing (OPLAH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$384.30 $549.00
OHu66981	XM_011516960.1 Latest version!	Homo sapiens 5-oxoprolinase, ATP-hydrolysing (OPLAH), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$727.30 $1039.00
View Old Accession Versions >>
OHu28255	NM_017570.4	Homo sapiens 5-oxoprolinase, ATP-hydrolysing (OPLAH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$384.30 $549.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OPLAH ( NM_017570.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060040.1 Homo sapiens 5-oxoprolinase, ATP-hydrolysing (OPLAH), mRNA.

Price & Availability↑

CloneID	OHu28255
Clone ID Related Accession (Same CDS sequence)	NM_017570.4 , NM_017570.5
Accession Version	NM_017570.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	5-oxoprolinase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC142672.1 and AC109322.16. This sequence is a reference standard in the RefSeqGene project. On Mar 3, 2014 this sequence version replaced NM_017570.3. ##Evidence-Data-START## Transcript exon combination :: BC142672.1, BC150206.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAGCC CCGAGGGCCG CTTCCACTTT GCCATCGACC GTGGGGGTAC CTTCACAGAC 
GTCTTTGCCC AGTGCCCAGG GGGGCACGTG CGGGTCTTAA AACTGCTCTC AGAGGACCCT 
GCCAACTATG CGGACGCGCC AACCGAAGGC ATCCGCCGCA TCCTGGAGCA GGAGGCCGGC 
ATGCTCCTGC CCCGGGACCA GCCGCTGGAC TCCAGTCATA TCGCCAGCAT CCGCATGGGC 
ACCACAGTGG CCACCAACGC ACTGCTGGAG CGGAAGGGGG AGCGGGTGGC GCTGCTGGTG 
ACACGTGGCT TCCGAGACCT GCTGCACATT GGCACCCAAG CCCGTGGGGA CCTCTTTGAC 
CTGGCCGTGC CCATGCCTGA GGTGCTGTAT GAAGAGGTGC TGGAGGTGGA CGAACGCGTG 
GTGCTGCACC GTGGAGAGGC GGGCACCGGG ACGCCTGTGA AAGGCCGCAC GGGGGACCTG 
CTGGAAGTGC AGCAGCCTGT GGACCTGGGG GCCCTGCGTG GGAAGCTGGA GGGGCTGCTA 
TCTCGAGGCA TCCGCAGCCT GGCTGTGGTG CTCATGCACT CGTACACGTG GGCCCAGCAT 
GAGCAGCAGG TGGGTGTGCT GGCCCGGGAG CTGGGCTTCA CGCACGTGTC ACTGTCCTCG 
GAGGCCATGC CCATGGTGCG CATCGTCCCT CGGGGGCACA CGGCCTGTGC CGACGCCTAC 
CTCACGCCCG CCATCCAGCG CTACGTGCAG GGCTTCTGCC GTGGCTTCCA GGGCCAACTC 
AAGGATGTGC AGGTGTTGTT CATGCGCTCC GATGGCGGCC TGGCGCCCAT GGACACCTTC 
AGCGGCTCCA GTGCTGTGCT CTCGGGCCCG GCCGGCGGCG TGGTGGGCTA CTCAGCCACC 
ACCTACCAGC AGGAGGGTGG CCAGCCTGTC ATCGGCTTTG ACATGGGAGG CACGTCCACG 
GATGTGAGCC GCTATGCTGG GGAATTCGAG CACGTCTTCG AGGCCAGCAC AGCTGGCGTC 
ACCCTCCAGG CCCCGCAGCT GGACATCAAC ACCGTGGCAG CGGGAGGGGG TTCCCGCCTC 
TTCTTCAGGT CTGGCCTCTT TGTGGTTGGG CCCGAGTCAG CAGGAGCCCA CCCAGGACCC 
GCCTGCTACC GCAAAGGGGG CCCTGTGACA GTGACGGATG CTAATCTGGT CCTGGGTCGC 
CTGCTGCCTG CCTCCTTCCC CTGCATTTTT GGGCCGGGAG AGAACCAACC ACTTTCCCCT 
GAGGCCTCCC GCAAAGCCCT GGAGGCTGTG GCCACTGAGG TCAACAGCTT CCTGACCAAC 
GGGCCCTGCC CGGCCTCCCC GCTGAGCCTG GAGGAGGTGG CCATGGGGTT CGTGCGCGTG 
GCCAACGAGG CCATGTGCCG GCCCATCCGT GCACTCACGC AGGCAAGAGG CCATGACCCC 
TCAGCCCATG TGCTGGCCTG CTTTGGGGGA GCTGGTGGGC AGCATGCATG TGCCATCGCC 
CGGGCCCTGG GCATGGACAC GGTGCACATC CACAGGCACA GTGGGCTGCT GTCGGCCCTG 
GGGCTGGCCC TGGCTGACGT GGTGCATGAG GCACAGGAAC CCTGCTCCCT GCTCTACGCG 
CCTGAGACCT TCGTGCAGCT GGACCAGAGG CTGAGCCGCC TGGAGGAGCA GTGTGTGGAT 
GCTCTGCAGG CCCAGGGCTT CCCCAGGTCC CAGATCAGCA CTGAGAGCTT CCTGCACCTG 
CGCTACCAGG GCACGGACTG TGCTCTGATG GTGTCTGCCC ACCAGCACCC AGCCACAGCC 
CGCTCGCCCC GTGCGGGGGA CTTCGGGGCA GCCTTTGTGG AGCGGTACAT GAGGGAGTTT 
GGCTTTGTCA TACCTGAGCG GCCGGTGGTC GTGGACGATG TGCGAGTGCG GGGCACCGGC 
CGCAGTGGTC TTCGCCTCGA GGATGCCCCC AAAGCCCAGA CCGGGCCTCC CCGGGTGGAC 
AAGATGACCC AGTGCTACTT TGAGGGGGGC TACCAGGAGA CCCCTGTGTA CCTGCTGGCA 
GAGCTGGGCT ATGGGCACAA GCTCCATGGG CCCTGCCTCA TCATCGACAG TAACAGCACC 
ATCCTGGTGG AGCCAGGTTG CCAGGCAGAG GTGACCAAGA CAGGGGACAT CTGCATCTCC 
GTGGGGGCCG AAGTCCCCGG CACAGTGGGC CCCCAGCTGG ACCCTATCCA GCTGTCCATC 
TTCTCACACC GCTTCATGAG CATTGCTGAG CAGATGGGCC GCATCCTGCA GCGCACAGCC 
ATCTCCACCA ACATCAAGGA GCGTCTGGAC TTCTCCTGTG CCCTCTTTGG GCCCGATGGG 
GGGCTGGTGT CCAATGCCCC CCACATCCCT GTGCACCTGG GTGCCATGCA GGAGACGGTG 
CAGTTCCAGA TTCAGCACCT GGGGGCCGAT CTCCACCCTG GCGACGTGCT ACTGAGCAAC 
CATCCCAGTG CCGGGGGCAG CCACCTGCCA GACCTGACTG TTATCACACC GGTGTTTTGG 
CCGGGTCAGA CGCGGCCTGT GTTCTATGTG GCCAGCCGAG GGCACCACGC AGACATCGGG 
GGCATCACAC CAGGCTCCAT GCCCCCCCAC TCCACCATGC TGCAACAGGA GGGTGCCGTC 
TTTCTGTCCT TCAAACTTGT CCAGGGGGGC GTCTTCCAGG AGGAGGCGGT GACGGAGGCC 
CTGCGGGCGC CAGGCAAGGT CCCCAACTGC AGCGGAACCA GAAACCTGCA CGACAACCTG 
TCGGACCTCC GTGCCCAGGT GGCAGCCAAC CAGAAGGGCA TCCAGCTGGT GGGGGAGCTC 
ATTGGGCAGT ACGGCCTGGA CGTGGTGCAG GCCTACATGG GCCATATTCA GGCAAACGCT 
GAGCTGGCCG TGCGAGACAT GTTGCGTGCC TTTGGAACCT CCCGGCAGGC CCGGGGCCTG 
CCCCTGGAGG TGTCCTCGGA AGACCACATG GACGACGGTT CCCCCATCCG CCTCCGTGTG 
CAGATCAGCC TGAGTCAGGG CAGCGCCGTG TTTGACTTCA GCGGCACTGG GCCGGAGGTG 
TTTGGTAATC TCAACGCACC GCGGGCCGTA ACCCTGTCCG CCCTCATCTA CTGCCTGCGC 
TGTCTGGTGG GCCGCGACAT CCCACTCAAC CAGGGCTGCC TGGCGCCAGT GCGCGTGGTC 
ATTCCCCGAG GCTCCATCCT GGACCCGTCG CCCGAGGCGG CGGTGGTGGG CGGCAACGTG 
CTCACGTCGC AGCGCGTGGT GGATGTCATC CTGGGGGCCT TTGGGGCCTG CGCCGCCTCC 
CAGGGCTGCA TGAACAACGT GACCCTGGGC AACGCCCACA TGGGCTACTA CGAGACGGTG 
GCGGGCGGCG CGGGCGCGGG TCCCAGCTGG CACGGGCGCA GCGGTGTGCA CAGCCACATG 
ACCAACACAC GCATCACCGA CCCTGAGATC CTGGAGAGCC GGTACCCGGT CATCCTGCGC 
CGCTTCGAGC TGCGGCGGGG CTCGGGGGGC AGAGGCCGCT TCCGAGGCGG CGACGGCGTC 
ACCCGCGAGC TGCTCTTTCG TGAGGAGGCG CTGCTGTCAG TGCTGACCGA GCGCCGCGCC 
TTCCGGCCAT ACGGGCTCCA CGGGGGCGAG CCTGGCGCCC GCGGCCTAAA CCTGCTGATC 
CGCAAAAACG GCCGGACGGT GAATCTGGGC GGCAAGACGT CGGTGACCGT GTACCCCGGG 
GATGTGTTCT GTCTCCACAC GCCCGGCGGC GGTGGCTATG GGGACCCGGA GGACCCCGCC 
CCACCGCCGG GGTCGCCCCC GCAAGCACTG GCCTTTCCCG AGCACGGCAG CGTCTATGAG 
TATCGCCGGG CCCAGGAGGC CGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060040.1
CDS	105..3971
Translation	MGSPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYADAPTEGIRRILEQEAGMLLPRDQPLDSSHIASIRMGTTVATNALLERKGERVALLVTRGFRDLLHIGTQARGDLFDLAVPMPEVLYEEVLEVDERVVLHRGEAGTGTPVKGRTGDLLEVQQPVDLGALRGKLEGLLSRGIRSLAVVLMHSYTWAQHEQQVGVLARELGFTHVSLSSEAMPMVRIVPRGHTACADAYLTPAIQRYVQGFCRGFQGQLKDVQVLFMRSDGGLAPMDTFSGSSAVLSGPAGGVVGYSATTYQQEGGQPVIGFDMGGTSTDVSRYAGEFEHVFEASTAGVTLQAPQLDINTVAAGGGSRLFFRSGLFVVGPESAGAHPGPACYRKGGPVTVTDANLVLGRLLPASFPCIFGPGENQPLSPEASRKALEAVATEVNSFLTNGPCPASPLSLEEVAMGFVRVANEAMCRPIRALTQARGHDPSAHVLACFGGAGGQHACAIARALGMDTVHIHRHSGLLSALGLALADVVHEAQEPCSLLYAPETFVQLDQRLSRLEEQCVDALQAQGFPRSQISTESFLHLRYQGTDCALMVSAHQHPATARSPRAGDFGAAFVERYMREFGFVIPERPVVVDDVRVRGTGRSGLRLEDAPKAQTGPPRVDKMTQCYFEGGYQETPVYLLAELGYGHKLHGPCLIIDSNSTILVEPGCQAEVTKTGDICISVGAEVPGTVGPQLDPIQLSIFSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQFQIQHLGADLHPGDVLLSNHPSAGGSHLPDLTVITPVFWPGQTRPVFYVASRGHHADIGGITPGSMPPHSTMLQQEGAVFLSFKLVQGGVFQEEAVTEALRAPGKVPNCSGTRNLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYMGHIQANAELAVRDMLRAFGTSRQARGLPLEVSSEDHMDDGSPIRLRVQISLSQGSAVFDFSGTGPEVFGNLNAPRAVTLSALIYCLRCLVGRDIPLNQGCLAPVRVVIPRGSILDPSPEAAVVGGNVLTSQRVVDVILGAFGACAASQGCMNNVTLGNAHMGYYETVAGGAGAGPSWHGRSGVHSHMTNTRITDPEILESRYPVILRRFELRRGSGGRGRFRGGDGVTRELLFREEALLSVLTERRAFRPYGLHGGEPGARGLNLLIRKNGRTVNLGGKTSVTVYPGDVFCLHTPGGGGYGDPEDPAPPPGSPPQALAFPEHGSVYEYRRAQEAV

Target ORF information:

RefSeq Version	NM_017570.4
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-oxoprolinase, ATP-hydrolysing (OPLAH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017570.4

ORF Insert Sequence:

ATGGGCAGCC CCGAGGGCCG CTTCCACTTT GCCATCGACC GTGGGGGTAC CTTCACAGAC 
GTCTTTGCCC AGTGCCCAGG GGGGCACGTG CGGGTCTTAA AACTGCTCTC AGAGGACCCT 
GCCAACTATG CGGACGCGCC AACCGAAGGC ATCCGCCGCA TCCTGGAGCA GGAGGCCGGC 
ATGCTCCTGC CCCGGGACCA GCCGCTGGAC TCCAGTCATA TCGCCAGCAT CCGCATGGGC 
ACCACAGTGG CCACCAACGC ACTGCTGGAG CGGAAGGGGG AGCGGGTGGC GCTGCTGGTG 
ACACGTGGCT TCCGAGACCT GCTGCACATT GGCACCCAAG CCCGTGGGGA CCTCTTTGAC 
CTGGCCGTGC CCATGCCTGA GGTGCTGTAT GAAGAGGTGC TGGAGGTGGA CGAACGCGTG 
GTGCTGCACC GTGGAGAGGC GGGCACCGGG ACGCCTGTGA AAGGCCGCAC GGGGGACCTG 
CTGGAAGTGC AGCAGCCTGT GGACCTGGGG GCCCTGCGTG GGAAGCTGGA GGGGCTGCTA 
TCTCGAGGCA TCCGCAGCCT GGCTGTGGTG CTCATGCACT CGTACACGTG GGCCCAGCAT 
GAGCAGCAGG TGGGTGTGCT GGCCCGGGAG CTGGGCTTCA CGCACGTGTC ACTGTCCTCG 
GAGGCCATGC CCATGGTGCG CATCGTCCCT CGGGGGCACA CGGCCTGTGC CGACGCCTAC 
CTCACGCCCG CCATCCAGCG CTACGTGCAG GGCTTCTGCC GTGGCTTCCA GGGCCAACTC 
AAGGATGTGC AGGTGTTGTT CATGCGCTCC GATGGCGGCC TGGCGCCCAT GGACACCTTC 
AGCGGCTCCA GTGCTGTGCT CTCGGGCCCG GCCGGCGGCG TGGTGGGCTA CTCAGCCACC 
ACCTACCAGC AGGAGGGTGG CCAGCCTGTC ATCGGCTTTG ACATGGGAGG CACGTCCACG 
GATGTGAGCC GCTATGCTGG GGAATTCGAG CACGTCTTCG AGGCCAGCAC AGCTGGCGTC 
ACCCTCCAGG CCCCGCAGCT GGACATCAAC ACCGTGGCAG CGGGAGGGGG TTCCCGCCTC 
TTCTTCAGGT CTGGCCTCTT TGTGGTTGGG CCCGAGTCAG CAGGAGCCCA CCCAGGACCC 
GCCTGCTACC GCAAAGGGGG CCCTGTGACA GTGACGGATG CTAATCTGGT CCTGGGTCGC 
CTGCTGCCTG CCTCCTTCCC CTGCATTTTT GGGCCGGGAG AGAACCAACC ACTTTCCCCT 
GAGGCCTCCC GCAAAGCCCT GGAGGCTGTG GCCACTGAGG TCAACAGCTT CCTGACCAAC 
GGGCCCTGCC CGGCCTCCCC GCTGAGCCTG GAGGAGGTGG CCATGGGGTT CGTGCGCGTG 
GCCAACGAGG CCATGTGCCG GCCCATCCGT GCACTCACGC AGGCAAGAGG CCATGACCCC 
TCAGCCCATG TGCTGGCCTG CTTTGGGGGA GCTGGTGGGC AGCATGCATG TGCCATCGCC 
CGGGCCCTGG GCATGGACAC GGTGCACATC CACAGGCACA GTGGGCTGCT GTCGGCCCTG 
GGGCTGGCCC TGGCTGACGT GGTGCATGAG GCACAGGAAC CCTGCTCCCT GCTCTACGCG 
CCTGAGACCT TCGTGCAGCT GGACCAGAGG CTGAGCCGCC TGGAGGAGCA GTGTGTGGAT 
GCTCTGCAGG CCCAGGGCTT CCCCAGGTCC CAGATCAGCA CTGAGAGCTT CCTGCACCTG 
CGCTACCAGG GCACGGACTG TGCTCTGATG GTGTCTGCCC ACCAGCACCC AGCCACAGCC 
CGCTCGCCCC GTGCGGGGGA CTTCGGGGCA GCCTTTGTGG AGCGGTACAT GAGGGAGTTT 
GGCTTTGTCA TACCTGAGCG GCCGGTGGTC GTGGACGATG TGCGAGTGCG GGGCACCGGC 
CGCAGTGGTC TTCGCCTCGA GGATGCCCCC AAAGCCCAGA CCGGGCCTCC CCGGGTGGAC 
AAGATGACCC AGTGCTACTT TGAGGGGGGC TACCAGGAGA CCCCTGTGTA CCTGCTGGCA 
GAGCTGGGCT ATGGGCACAA GCTCCATGGG CCCTGCCTCA TCATCGACAG TAACAGCACC 
ATCCTGGTGG AGCCAGGTTG CCAGGCAGAG GTGACCAAGA CAGGGGACAT CTGCATCTCC 
GTGGGGGCCG AAGTCCCCGG CACAGTGGGC CCCCAGCTGG ACCCTATCCA GCTGTCCATC 
TTCTCACACC GCTTCATGAG CATTGCTGAG CAGATGGGCC GCATCCTGCA GCGCACAGCC 
ATCTCCACCA ACATCAAGGA GCGTCTGGAC TTCTCCTGTG CCCTCTTTGG GCCCGATGGG 
GGGCTGGTGT CCAATGCCCC CCACATCCCT GTGCACCTGG GTGCCATGCA GGAGACGGTG 
CAGTTCCAGA TTCAGCACCT GGGGGCCGAT CTCCACCCTG GCGACGTGCT ACTGAGCAAC 
CATCCCAGTG CCGGGGGCAG CCACCTGCCA GACCTGACTG TTATCACACC GGTGTTTTGG 
CCGGGTCAGA CGCGGCCTGT GTTCTATGTG GCCAGCCGAG GGCACCACGC AGACATCGGG 
GGCATCACAC CAGGCTCCAT GCCCCCCCAC TCCACCATGC TGCAACAGGA GGGTGCCGTC 
TTTCTGTCCT TCAAACTTGT CCAGGGGGGC GTCTTCCAGG AGGAGGCGGT GACGGAGGCC 
CTGCGGGCGC CAGGCAAGGT CCCCAACTGC AGCGGAACCA GAAACCTGCA CGACAACCTG 
TCGGACCTCC GTGCCCAGGT GGCAGCCAAC CAGAAGGGCA TCCAGCTGGT GGGGGAGCTC 
ATTGGGCAGT ACGGCCTGGA CGTGGTGCAG GCCTACATGG GCCATATTCA GGCAAACGCT 
GAGCTGGCCG TGCGAGACAT GTTGCGTGCC TTTGGAACCT CCCGGCAGGC CCGGGGCCTG 
CCCCTGGAGG TGTCCTCGGA AGACCACATG GACGACGGTT CCCCCATCCG CCTCCGTGTG 
CAGATCAGCC TGAGTCAGGG CAGCGCCGTG TTTGACTTCA GCGGCACTGG GCCGGAGGTG 
TTTGGTAATC TCAACGCACC GCGGGCCGTA ACCCTGTCCG CCCTCATCTA CTGCCTGCGC 
TGTCTGGTGG GCCGCGACAT CCCACTCAAC CAGGGCTGCC TGGCGCCAGT GCGCGTGGTC 
ATTCCCCGAG GCTCCATCCT GGACCCGTCG CCCGAGGCGG CGGTGGTGGG CGGCAACGTG 
CTCACGTCGC AGCGCGTGGT GGATGTCATC CTGGGGGCCT TTGGGGCCTG CGCCGCCTCC 
CAGGGCTGCA TGAACAACGT GACCCTGGGC AACGCCCACA TGGGCTACTA CGAGACGGTG 
GCGGGCGGCG CGGGCGCGGG TCCCAGCTGG CACGGGCGCA GCGGTGTGCA CAGCCACATG 
ACCAACACAC GCATCACCGA CCCTGAGATC CTGGAGAGCC GGTACCCGGT CATCCTGCGC 
CGCTTCGAGC TGCGGCGGGG CTCGGGGGGC AGAGGCCGCT TCCGAGGCGG CGACGGCGTC 
ACCCGCGAGC TGCTCTTTCG TGAGGAGGCG CTGCTGTCAG TGCTGACCGA GCGCCGCGCC 
TTCCGGCCAT ACGGGCTCCA CGGGGGCGAG CCTGGCGCCC GCGGCCTAAA CCTGCTGATC 
CGCAAAAACG GCCGGACGGT GAATCTGGGC GGCAAGACGT CGGTGACCGT GTACCCCGGG 
GATGTGTTCT GTCTCCACAC GCCCGGCGGC GGTGGCTATG GGGACCCGGA GGACCCCGCC 
CCACCGCCGG GGTCGCCCCC GCAAGCACTG GCCTTTCCCG AGCACGGCAG CGTCTATGAG 
TATCGCCGGG CCCAGGAGGC CGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPLAH ( NM_017570.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_060040.1 Homo sapiens 5-oxoprolinase, ATP-hydrolysing (OPLAH), mRNA.

Price & Availability↑

CloneID	OHu28255
Clone ID Related Accession (Same CDS sequence)	NM_017570.4 , NM_017570.5
Accession Version	NM_017570.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	5-oxoprolinase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC142672.1 and AC109322.16. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_017570.4. ##Evidence-Data-START## Transcript exon combination :: BC142672.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000618853.5/ ENSP00000480476.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCAGCC CCGAGGGCCG CTTCCACTTT GCCATCGACC GTGGGGGTAC CTTCACAGAC 
GTCTTTGCCC AGTGCCCAGG GGGGCACGTG CGGGTCTTAA AACTGCTCTC AGAGGACCCT 
GCCAACTATG CGGACGCGCC AACCGAAGGC ATCCGCCGCA TCCTGGAGCA GGAGGCCGGC 
ATGCTCCTGC CCCGGGACCA GCCGCTGGAC TCCAGTCATA TCGCCAGCAT CCGCATGGGC 
ACCACAGTGG CCACCAACGC ACTGCTGGAG CGGAAGGGGG AGCGGGTGGC GCTGCTGGTG 
ACACGTGGCT TCCGAGACCT GCTGCACATT GGCACCCAAG CCCGTGGGGA CCTCTTTGAC 
CTGGCCGTGC CCATGCCTGA GGTGCTGTAT GAAGAGGTGC TGGAGGTGGA CGAACGCGTG 
GTGCTGCACC GTGGAGAGGC GGGCACCGGG ACGCCTGTGA AAGGCCGCAC GGGGGACCTG 
CTGGAAGTGC AGCAGCCTGT GGACCTGGGG GCCCTGCGTG GGAAGCTGGA GGGGCTGCTA 
TCTCGAGGCA TCCGCAGCCT GGCTGTGGTG CTCATGCACT CGTACACGTG GGCCCAGCAT 
GAGCAGCAGG TGGGTGTGCT GGCCCGGGAG CTGGGCTTCA CGCACGTGTC ACTGTCCTCG 
GAGGCCATGC CCATGGTGCG CATCGTCCCT CGGGGGCACA CGGCCTGTGC CGACGCCTAC 
CTCACGCCCG CCATCCAGCG CTACGTGCAG GGCTTCTGCC GTGGCTTCCA GGGCCAACTC 
AAGGATGTGC AGGTGTTGTT CATGCGCTCC GATGGCGGCC TGGCGCCCAT GGACACCTTC 
AGCGGCTCCA GTGCTGTGCT CTCGGGCCCG GCCGGCGGCG TGGTGGGCTA CTCAGCCACC 
ACCTACCAGC AGGAGGGTGG CCAGCCTGTC ATCGGCTTTG ACATGGGAGG CACGTCCACG 
GATGTGAGCC GCTATGCTGG GGAATTCGAG CACGTCTTCG AGGCCAGCAC AGCTGGCGTC 
ACCCTCCAGG CCCCGCAGCT GGACATCAAC ACCGTGGCAG CGGGAGGGGG TTCCCGCCTC 
TTCTTCAGGT CTGGCCTCTT TGTGGTTGGG CCCGAGTCAG CAGGAGCCCA CCCAGGACCC 
GCCTGCTACC GCAAAGGGGG CCCTGTGACA GTGACGGATG CTAATCTGGT CCTGGGTCGC 
CTGCTGCCTG CCTCCTTCCC CTGCATTTTT GGGCCGGGAG AGAACCAACC ACTTTCCCCT 
GAGGCCTCCC GCAAAGCCCT GGAGGCTGTG GCCACTGAGG TCAACAGCTT CCTGACCAAC 
GGGCCCTGCC CGGCCTCCCC GCTGAGCCTG GAGGAGGTGG CCATGGGGTT CGTGCGCGTG 
GCCAACGAGG CCATGTGCCG GCCCATCCGT GCACTCACGC AGGCAAGAGG CCATGACCCC 
TCAGCCCATG TGCTGGCCTG CTTTGGGGGA GCTGGTGGGC AGCATGCATG TGCCATCGCC 
CGGGCCCTGG GCATGGACAC GGTGCACATC CACAGGCACA GTGGGCTGCT GTCGGCCCTG 
GGGCTGGCCC TGGCTGACGT GGTGCATGAG GCACAGGAAC CCTGCTCCCT GCTCTACGCG 
CCTGAGACCT TCGTGCAGCT GGACCAGAGG CTGAGCCGCC TGGAGGAGCA GTGTGTGGAT 
GCTCTGCAGG CCCAGGGCTT CCCCAGGTCC CAGATCAGCA CTGAGAGCTT CCTGCACCTG 
CGCTACCAGG GCACGGACTG TGCTCTGATG GTGTCTGCCC ACCAGCACCC AGCCACAGCC 
CGCTCGCCCC GTGCGGGGGA CTTCGGGGCA GCCTTTGTGG AGCGGTACAT GAGGGAGTTT 
GGCTTTGTCA TACCTGAGCG GCCGGTGGTC GTGGACGATG TGCGAGTGCG GGGCACCGGC 
CGCAGTGGTC TTCGCCTCGA GGATGCCCCC AAAGCCCAGA CCGGGCCTCC CCGGGTGGAC 
AAGATGACCC AGTGCTACTT TGAGGGGGGC TACCAGGAGA CCCCTGTGTA CCTGCTGGCA 
GAGCTGGGCT ATGGGCACAA GCTCCATGGG CCCTGCCTCA TCATCGACAG TAACAGCACC 
ATCCTGGTGG AGCCAGGTTG CCAGGCAGAG GTGACCAAGA CAGGGGACAT CTGCATCTCC 
GTGGGGGCCG AAGTCCCCGG CACAGTGGGC CCCCAGCTGG ACCCTATCCA GCTGTCCATC 
TTCTCACACC GCTTCATGAG CATTGCTGAG CAGATGGGCC GCATCCTGCA GCGCACAGCC 
ATCTCCACCA ACATCAAGGA GCGTCTGGAC TTCTCCTGTG CCCTCTTTGG GCCCGATGGG 
GGGCTGGTGT CCAATGCCCC CCACATCCCT GTGCACCTGG GTGCCATGCA GGAGACGGTG 
CAGTTCCAGA TTCAGCACCT GGGGGCCGAT CTCCACCCTG GCGACGTGCT ACTGAGCAAC 
CATCCCAGTG CCGGGGGCAG CCACCTGCCA GACCTGACTG TTATCACACC GGTGTTTTGG 
CCGGGTCAGA CGCGGCCTGT GTTCTATGTG GCCAGCCGAG GGCACCACGC AGACATCGGG 
GGCATCACAC CAGGCTCCAT GCCCCCCCAC TCCACCATGC TGCAACAGGA GGGTGCCGTC 
TTTCTGTCCT TCAAACTTGT CCAGGGGGGC GTCTTCCAGG AGGAGGCGGT GACGGAGGCC 
CTGCGGGCGC CAGGCAAGGT CCCCAACTGC AGCGGAACCA GAAACCTGCA CGACAACCTG 
TCGGACCTCC GTGCCCAGGT GGCAGCCAAC CAGAAGGGCA TCCAGCTGGT GGGGGAGCTC 
ATTGGGCAGT ACGGCCTGGA CGTGGTGCAG GCCTACATGG GCCATATTCA GGCAAACGCT 
GAGCTGGCCG TGCGAGACAT GTTGCGTGCC TTTGGAACCT CCCGGCAGGC CCGGGGCCTG 
CCCCTGGAGG TGTCCTCGGA AGACCACATG GACGACGGTT CCCCCATCCG CCTCCGTGTG 
CAGATCAGCC TGAGTCAGGG CAGCGCCGTG TTTGACTTCA GCGGCACTGG GCCGGAGGTG 
TTTGGTAATC TCAACGCACC GCGGGCCGTA ACCCTGTCCG CCCTCATCTA CTGCCTGCGC 
TGTCTGGTGG GCCGCGACAT CCCACTCAAC CAGGGCTGCC TGGCGCCAGT GCGCGTGGTC 
ATTCCCCGAG GCTCCATCCT GGACCCGTCG CCCGAGGCGG CGGTGGTGGG CGGCAACGTG 
CTCACGTCGC AGCGCGTGGT GGATGTCATC CTGGGGGCCT TTGGGGCCTG CGCCGCCTCC 
CAGGGCTGCA TGAACAACGT GACCCTGGGC AACGCCCACA TGGGCTACTA CGAGACGGTG 
GCGGGCGGCG CGGGCGCGGG TCCCAGCTGG CACGGGCGCA GCGGTGTGCA CAGCCACATG 
ACCAACACAC GCATCACCGA CCCTGAGATC CTGGAGAGCC GGTACCCGGT CATCCTGCGC 
CGCTTCGAGC TGCGGCGGGG CTCGGGGGGC AGAGGCCGCT TCCGAGGCGG CGACGGCGTC 
ACCCGCGAGC TGCTCTTTCG TGAGGAGGCG CTGCTGTCAG TGCTGACCGA GCGCCGCGCC 
TTCCGGCCAT ACGGGCTCCA CGGGGGCGAG CCTGGCGCCC GCGGCCTAAA CCTGCTGATC 
CGCAAAAACG GCCGGACGGT GAATCTGGGC GGCAAGACGT CGGTGACCGT GTACCCCGGG 
GATGTGTTCT GTCTCCACAC GCCCGGCGGC GGTGGCTATG GGGACCCGGA GGACCCCGCC 
CCACCGCCGG GGTCGCCCCC GCAAGCACTG GCCTTTCCCG AGCACGGCAG CGTCTATGAG 
TATCGCCGGG CCCAGGAGGC CGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060040.1
CDS	94..3960
Translation	MGSPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYADAPTEGIRRILEQEAGMLLPRDQPLDSSHIASIRMGTTVATNALLERKGERVALLVTRGFRDLLHIGTQARGDLFDLAVPMPEVLYEEVLEVDERVVLHRGEAGTGTPVKGRTGDLLEVQQPVDLGALRGKLEGLLSRGIRSLAVVLMHSYTWAQHEQQVGVLARELGFTHVSLSSEAMPMVRIVPRGHTACADAYLTPAIQRYVQGFCRGFQGQLKDVQVLFMRSDGGLAPMDTFSGSSAVLSGPAGGVVGYSATTYQQEGGQPVIGFDMGGTSTDVSRYAGEFEHVFEASTAGVTLQAPQLDINTVAAGGGSRLFFRSGLFVVGPESAGAHPGPACYRKGGPVTVTDANLVLGRLLPASFPCIFGPGENQPLSPEASRKALEAVATEVNSFLTNGPCPASPLSLEEVAMGFVRVANEAMCRPIRALTQARGHDPSAHVLACFGGAGGQHACAIARALGMDTVHIHRHSGLLSALGLALADVVHEAQEPCSLLYAPETFVQLDQRLSRLEEQCVDALQAQGFPRSQISTESFLHLRYQGTDCALMVSAHQHPATARSPRAGDFGAAFVERYMREFGFVIPERPVVVDDVRVRGTGRSGLRLEDAPKAQTGPPRVDKMTQCYFEGGYQETPVYLLAELGYGHKLHGPCLIIDSNSTILVEPGCQAEVTKTGDICISVGAEVPGTVGPQLDPIQLSIFSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQFQIQHLGADLHPGDVLLSNHPSAGGSHLPDLTVITPVFWPGQTRPVFYVASRGHHADIGGITPGSMPPHSTMLQQEGAVFLSFKLVQGGVFQEEAVTEALRAPGKVPNCSGTRNLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYMGHIQANAELAVRDMLRAFGTSRQARGLPLEVSSEDHMDDGSPIRLRVQISLSQGSAVFDFSGTGPEVFGNLNAPRAVTLSALIYCLRCLVGRDIPLNQGCLAPVRVVIPRGSILDPSPEAAVVGGNVLTSQRVVDVILGAFGACAASQGCMNNVTLGNAHMGYYETVAGGAGAGPSWHGRSGVHSHMTNTRITDPEILESRYPVILRRFELRRGSGGRGRFRGGDGVTRELLFREEALLSVLTERRAFRPYGLHGGEPGARGLNLLIRKNGRTVNLGGKTSVTVYPGDVFCLHTPGGGGYGDPEDPAPPPGSPPQALAFPEHGSVYEYRRAQEAV

Target ORF information:

RefSeq Version	NM_017570.5
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-oxoprolinase, ATP-hydrolysing (OPLAH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017570.5

ORF Insert Sequence:

ATGGGCAGCC CCGAGGGCCG CTTCCACTTT GCCATCGACC GTGGGGGTAC CTTCACAGAC 
GTCTTTGCCC AGTGCCCAGG GGGGCACGTG CGGGTCTTAA AACTGCTCTC AGAGGACCCT 
GCCAACTATG CGGACGCGCC AACCGAAGGC ATCCGCCGCA TCCTGGAGCA GGAGGCCGGC 
ATGCTCCTGC CCCGGGACCA GCCGCTGGAC TCCAGTCATA TCGCCAGCAT CCGCATGGGC 
ACCACAGTGG CCACCAACGC ACTGCTGGAG CGGAAGGGGG AGCGGGTGGC GCTGCTGGTG 
ACACGTGGCT TCCGAGACCT GCTGCACATT GGCACCCAAG CCCGTGGGGA CCTCTTTGAC 
CTGGCCGTGC CCATGCCTGA GGTGCTGTAT GAAGAGGTGC TGGAGGTGGA CGAACGCGTG 
GTGCTGCACC GTGGAGAGGC GGGCACCGGG ACGCCTGTGA AAGGCCGCAC GGGGGACCTG 
CTGGAAGTGC AGCAGCCTGT GGACCTGGGG GCCCTGCGTG GGAAGCTGGA GGGGCTGCTA 
TCTCGAGGCA TCCGCAGCCT GGCTGTGGTG CTCATGCACT CGTACACGTG GGCCCAGCAT 
GAGCAGCAGG TGGGTGTGCT GGCCCGGGAG CTGGGCTTCA CGCACGTGTC ACTGTCCTCG 
GAGGCCATGC CCATGGTGCG CATCGTCCCT CGGGGGCACA CGGCCTGTGC CGACGCCTAC 
CTCACGCCCG CCATCCAGCG CTACGTGCAG GGCTTCTGCC GTGGCTTCCA GGGCCAACTC 
AAGGATGTGC AGGTGTTGTT CATGCGCTCC GATGGCGGCC TGGCGCCCAT GGACACCTTC 
AGCGGCTCCA GTGCTGTGCT CTCGGGCCCG GCCGGCGGCG TGGTGGGCTA CTCAGCCACC 
ACCTACCAGC AGGAGGGTGG CCAGCCTGTC ATCGGCTTTG ACATGGGAGG CACGTCCACG 
GATGTGAGCC GCTATGCTGG GGAATTCGAG CACGTCTTCG AGGCCAGCAC AGCTGGCGTC 
ACCCTCCAGG CCCCGCAGCT GGACATCAAC ACCGTGGCAG CGGGAGGGGG TTCCCGCCTC 
TTCTTCAGGT CTGGCCTCTT TGTGGTTGGG CCCGAGTCAG CAGGAGCCCA CCCAGGACCC 
GCCTGCTACC GCAAAGGGGG CCCTGTGACA GTGACGGATG CTAATCTGGT CCTGGGTCGC 
CTGCTGCCTG CCTCCTTCCC CTGCATTTTT GGGCCGGGAG AGAACCAACC ACTTTCCCCT 
GAGGCCTCCC GCAAAGCCCT GGAGGCTGTG GCCACTGAGG TCAACAGCTT CCTGACCAAC 
GGGCCCTGCC CGGCCTCCCC GCTGAGCCTG GAGGAGGTGG CCATGGGGTT CGTGCGCGTG 
GCCAACGAGG CCATGTGCCG GCCCATCCGT GCACTCACGC AGGCAAGAGG CCATGACCCC 
TCAGCCCATG TGCTGGCCTG CTTTGGGGGA GCTGGTGGGC AGCATGCATG TGCCATCGCC 
CGGGCCCTGG GCATGGACAC GGTGCACATC CACAGGCACA GTGGGCTGCT GTCGGCCCTG 
GGGCTGGCCC TGGCTGACGT GGTGCATGAG GCACAGGAAC CCTGCTCCCT GCTCTACGCG 
CCTGAGACCT TCGTGCAGCT GGACCAGAGG CTGAGCCGCC TGGAGGAGCA GTGTGTGGAT 
GCTCTGCAGG CCCAGGGCTT CCCCAGGTCC CAGATCAGCA CTGAGAGCTT CCTGCACCTG 
CGCTACCAGG GCACGGACTG TGCTCTGATG GTGTCTGCCC ACCAGCACCC AGCCACAGCC 
CGCTCGCCCC GTGCGGGGGA CTTCGGGGCA GCCTTTGTGG AGCGGTACAT GAGGGAGTTT 
GGCTTTGTCA TACCTGAGCG GCCGGTGGTC GTGGACGATG TGCGAGTGCG GGGCACCGGC 
CGCAGTGGTC TTCGCCTCGA GGATGCCCCC AAAGCCCAGA CCGGGCCTCC CCGGGTGGAC 
AAGATGACCC AGTGCTACTT TGAGGGGGGC TACCAGGAGA CCCCTGTGTA CCTGCTGGCA 
GAGCTGGGCT ATGGGCACAA GCTCCATGGG CCCTGCCTCA TCATCGACAG TAACAGCACC 
ATCCTGGTGG AGCCAGGTTG CCAGGCAGAG GTGACCAAGA CAGGGGACAT CTGCATCTCC 
GTGGGGGCCG AAGTCCCCGG CACAGTGGGC CCCCAGCTGG ACCCTATCCA GCTGTCCATC 
TTCTCACACC GCTTCATGAG CATTGCTGAG CAGATGGGCC GCATCCTGCA GCGCACAGCC 
ATCTCCACCA ACATCAAGGA GCGTCTGGAC TTCTCCTGTG CCCTCTTTGG GCCCGATGGG 
GGGCTGGTGT CCAATGCCCC CCACATCCCT GTGCACCTGG GTGCCATGCA GGAGACGGTG 
CAGTTCCAGA TTCAGCACCT GGGGGCCGAT CTCCACCCTG GCGACGTGCT ACTGAGCAAC 
CATCCCAGTG CCGGGGGCAG CCACCTGCCA GACCTGACTG TTATCACACC GGTGTTTTGG 
CCGGGTCAGA CGCGGCCTGT GTTCTATGTG GCCAGCCGAG GGCACCACGC AGACATCGGG 
GGCATCACAC CAGGCTCCAT GCCCCCCCAC TCCACCATGC TGCAACAGGA GGGTGCCGTC 
TTTCTGTCCT TCAAACTTGT CCAGGGGGGC GTCTTCCAGG AGGAGGCGGT GACGGAGGCC 
CTGCGGGCGC CAGGCAAGGT CCCCAACTGC AGCGGAACCA GAAACCTGCA CGACAACCTG 
TCGGACCTCC GTGCCCAGGT GGCAGCCAAC CAGAAGGGCA TCCAGCTGGT GGGGGAGCTC 
ATTGGGCAGT ACGGCCTGGA CGTGGTGCAG GCCTACATGG GCCATATTCA GGCAAACGCT 
GAGCTGGCCG TGCGAGACAT GTTGCGTGCC TTTGGAACCT CCCGGCAGGC CCGGGGCCTG 
CCCCTGGAGG TGTCCTCGGA AGACCACATG GACGACGGTT CCCCCATCCG CCTCCGTGTG 
CAGATCAGCC TGAGTCAGGG CAGCGCCGTG TTTGACTTCA GCGGCACTGG GCCGGAGGTG 
TTTGGTAATC TCAACGCACC GCGGGCCGTA ACCCTGTCCG CCCTCATCTA CTGCCTGCGC 
TGTCTGGTGG GCCGCGACAT CCCACTCAAC CAGGGCTGCC TGGCGCCAGT GCGCGTGGTC 
ATTCCCCGAG GCTCCATCCT GGACCCGTCG CCCGAGGCGG CGGTGGTGGG CGGCAACGTG 
CTCACGTCGC AGCGCGTGGT GGATGTCATC CTGGGGGCCT TTGGGGCCTG CGCCGCCTCC 
CAGGGCTGCA TGAACAACGT GACCCTGGGC AACGCCCACA TGGGCTACTA CGAGACGGTG 
GCGGGCGGCG CGGGCGCGGG TCCCAGCTGG CACGGGCGCA GCGGTGTGCA CAGCCACATG 
ACCAACACAC GCATCACCGA CCCTGAGATC CTGGAGAGCC GGTACCCGGT CATCCTGCGC 
CGCTTCGAGC TGCGGCGGGG CTCGGGGGGC AGAGGCCGCT TCCGAGGCGG CGACGGCGTC 
ACCCGCGAGC TGCTCTTTCG TGAGGAGGCG CTGCTGTCAG TGCTGACCGA GCGCCGCGCC 
TTCCGGCCAT ACGGGCTCCA CGGGGGCGAG CCTGGCGCCC GCGGCCTAAA CCTGCTGATC 
CGCAAAAACG GCCGGACGGT GAATCTGGGC GGCAAGACGT CGGTGACCGT GTACCCCGGG 
GATGTGTTCT GTCTCCACAC GCCCGGCGGC GGTGGCTATG GGGACCCGGA GGACCCCGCC 
CCACCGCCGG GGTCGCCCCC GCAAGCACTG GCCTTTCCCG AGCACGGCAG CGTCTATGAG 
TATCGCCGGG CCCAGGAGGC CGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPLAH ( XM_011516960.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011515262.1 Homo sapiens 5-oxoprolinase, ATP-hydrolysing (OPLAH), transcript variant X1, mRNA.

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CloneID	OHu66981
Clone ID Related Accession (Same CDS sequence)	XM_011516960.1
Accession Version	XM_011516960.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	5-oxoprolinase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCTCC TCAGCAGCTA TGAGGGCCTG CGGCAGGAGA TCCAGCGGCT GGCACAGGAG 
AACGAAGAGC TGCGGCGGCT GGTGCAGCTC ATCCAGGAGA ACCAGGAGCT GAAGCTGGTG 
CTCAGGAACC GCGGCAGCAG CCTGGGCTTC TGCAGCTCCG GGTTCCTGGC TGAGGTGGCT 
GCCAGTCCCT GGCTACCCAG GCGGAGAACG ATCAAATTCA AGAATGCTGA GAGAGTTTTT 
CCAGGGCTAC CAGCTGAAGA GCTCCTGTGG GACTCCAGCC CCACCACCAT GGGCAGCCCC 
GAGGGCCGCT TCCACTTTGC CATCGACCGT GGGGGTACCT TCACAGACGT CTTTGCCCAG 
TGCCCAGGGG GGCACGTGCG GGTCTTAAAA CTGCTCTCAG AGGACCCTGC CAACTATGCG 
GACGCGCCAA CCGAAGGCAT CCGCCGCATC CTGGAGCAGG AGGCCGGCAT GCTCCTGCCC 
CGGGACCAGC CGCTGGACTC CAGTCATATC GCCAGCATCC GCATGGGCAC CACAGTGGCC 
ACCAACGCAC TGCTGGAGCG GAAGGGGGAG CGGGTGGCGC TGCTGGTGAC ACGTGGCTTC 
CGAGACCTGC TGCACATTGG CACCCAAGCC CGTGGGGACC TCTTTGACCT GGCCGTGCCC 
ATGCCTGAGG TGCTGTATGA AGAGGTGCTG GAGGTGGACG AACGCGTGGT GCTGCACCGT 
GGAGAGGCGG GCACCGGGAC GCCTGTGAAA GGCCGCACGG GGGACCTGCT GGAAGTGCAG 
CAGCCTGTGG ACCTGGGGGC CCTGCGTGGG AAGCTGGAGG GGCTGCTATC TCGAGGCATC 
CGCAGCCTGG CTGTGGTGCT CATGCACTCG TACACGTGGG CCCAGCATGA GCAGCAGGTG 
GGTGTGCTGG CCCGGGAGCT GGGCTTCACG CACGTGTCAC TGTCCTCGGA GGCCATGCCC 
ATGGTGCGCA TCGTCCCTCG GGGGCACACG GCCTGTGCCG ACGCCTACCT CACGCCCGCC 
ATCCAGCGCT ACGTGCAGGG CTTCTGCCGT GGCTTCCAGG GCCAACTCAA GGATGTGCAG 
GTGTTGTTCA TGCGCTCCGA TGGCGGCCTG GCGCCCATGG ACACCTTCAG CGGCTCCAGT 
GCTGTGCTCT CGGGCCCGGC CGGCGGCGTG GTGGGCTACT CAGCCACCAC CTACCAGCAG 
GAGGGTGGCC AGCCTGTCAT CGGCTTTGAC ATGGGAGGCA CGTCCACGGA TGTGAGCCGC 
TATGCTGGGG AATTCGAGCA CGTCTTCGAG GCCAGCACAG CTGGCGTCAC CCTCCAGGCC 
CCGCAGCTGG ACATCAACAC CGTGGCAGCG GGAGGGGGTT CCCGCCTCTT CTTCAGGTCT 
GGCCTCTTTG TGGTTGGGCC CGAGTCAGCA GGAGCCCACC CAGGACCCGC CTGCTACCGC 
AAAGGGGGCC CTGTGACAGT GACGGATGCT AATCTGGTCC TGGGTCGCCT GCTGCCTGCC 
TCCTTCCCCT GCATTTTTGG GCCGGGAGAG AACCAACCAC TTTCCCCTGA GGCCTCCCGC 
AAAGCCCTGG AGGCTGTGGC CACTGAGGTC AACAGCTTCC TGACCAACGG GCCCTGCCCG 
GCCTCCCCGC TGAGCCTGGA GGAGGTGGCC ATGGGGTTCG TGCGCGTGGC CAACGAGGCC 
ATGTGCCGGC CCATCCGTGC ACTCACGCAG GCAAGAGGCC ATGACCCCTC AGCCCATGTG 
CTGGCCTGCT TTGGGGGAGC TGGTGGGCAG CATGCATGTG CCATCGCCCG GGCCCTGGGC 
ATGGACACGG TGCACATCCA CAGGCACAGT GGGCTGCTGT CGGCCCTGGG GCTGGCCCTG 
GCTGACGTGG TGCATGAGGC ACAGGAACCC TGCTCCCTGC TCTACGCGCC TGAGACCTTC 
GTGCAGCTGG ACCAGAGGCT GAGCCGCCTG GAGGAGCAGT GTGTGGATGC TCTGCAGGCC 
CAGGGCTTCC CCAGGTCCCA GATCAGCACT GAGAGCTTCC TGCACCTGCG CTACCAGGGC 
ACGGACTGTG CTCTGATGGT GTCTGCCCAC CAGCACCCAG CCACAGCCCG CTCGCCCCGT 
GCGGGGGACT TCGGGGCAGC CTTTGTGGAG CGGTACATGA GGGAGTTTGG CTTTGTCATA 
CCTGAGCGGC CGGTGGTCGT GGACGATGTG CGAGTGCGGG GCACCGGCCG CAGTGGTCTT 
CGCCTCGAGG ATGCCCCCAA AGCCCAGACC GGGCCTCCCC GGGTGGACAA GATGACCCAG 
TGCTACTTTG AGGGGGGCTA CCAGGAGACC CCTGTGTACC TGCTGGCAGA GCTGGGCTAT 
GGGCACAAGC TCCATGGGCC CTGCCTCATC ATCGACAGTA ACAGCACCAT CCTGGTGGAG 
CCAGGTTGCC AGGCAGAGGT GACCAAGACA GGGGACATCT GCATCTCCGT GGGGGCCGAA 
GTCCCCGGCA CAGTGGGCCC CCAGCTGGAC CCTATCCAGC TGTCCATCTT CTCACACCGC 
TTCATGAGCA TTGCTGAGCA GATGGGCCGC ATCCTGCAGC GCACAGCCAT CTCCACCAAC 
ATCAAGGAGC GTCTGGACTT CTCCTGTGCC CTCTTTGGGC CCGATGGGGG GCTGGTGTCC 
AATGCCCCCC ACATCCCTGT GCACCTGGGT GCCATGCAGG AGACGGTGCA GTTCCAGATT 
CAGCACCTGG GGGCCGATCT CCACCCTGGC GACGTGCTAC TGAGCAACCA TCCCAGTGCC 
GGGGGCAGCC ACCTGCCAGA CCTGACTGTT ATCACACCGG TGTTTTGGCC GGGTCAGACG 
CGGCCTGTGT TCTATGTGGC CAGCCGAGGG CACCACGCAG ACATCGGGGG CATCACACCA 
GGCTCCATGC CCCCCCACTC CACCATGCTG CAACAGGAGG GTGCCGTCTT TCTGTCCTTC 
AAACTTGTCC AGGGGGGCGT CTTCCAGGAG GAGGCGGTGA CGGAGGCCCT GCGGGCGCCA 
GGCAAGGTCC CCAACTGCAG CGGAACCAGA AACCTGCACG ACAACCTGTC GGACCTCCGT 
GCCCAGGTGG CAGCCAACCA GAAGGGCATC CAGCTGGTGG GGGAGCTCAT TGGGCAGTAC 
GGCCTGGACG TGGTGCAGGC CTACATGGGC CATATTCAGG CAAACGCTGA GCTGGCCGTG 
CGAGACATGT TGCGTGCCTT TGGAACCTCC CGGCAGGCCC GGGGCCTGCC CCTGGAGGTG 
TCCTCGGAAG ACCACATGGA CGACGGTTCC CCCATCCGCC TCCGTGTGCA GATCAGCCTG 
AGTCAGGGCA GCGCCGTGTT TGACTTCAGC GGCACTGGGC CGGAGGTGTT TGGTAATCTC 
AACGCACCGC GGGCCGTAAC CCTGTCCGCC CTCATCTACT GCCTGCGCTG TCTGGTGGGC 
CGCGACATCC CACTCAACCA GGGCTGCCTG GCGCCAGTGC GCGTGGTCAT TCCCCGAGGC 
TCCATCCTGG ACCCGTCGCC CGAGGCGGCG GTGGTGGGCG GCAACGTGCT CACGTCGCAG 
CGCGTGGTGG ATGTCATCCT GGGGGCCTTT GGGGCCTGCG CCGCCTCCCA GGGCTGCATG 
AACAACGTGA CCCTGGGCAA CGCCCACATG GGCTACTACG AGACGGTGGC GGGCGGCGCG 
GGCGCGGGTC CCAGCTGGCA CGGGCGCAGC GGTGTGCACA GCCACATGAC CAACACACGC 
ATCACCGACC CTGAGATCCT GGAGAGCCGG TACCCGGTCA TCCTGCGCCG CTTCGAGCTG 
CGGCGGGGCT CGGGGGGCAG AGGCCGCTTC CGAGGCGGCG ACGGCGTCAC CCGCGAGCTG 
CTCTTTCGTG AGGAGGCGCT GCTGTCAGTG CTGACCGAGC GCCGCGCCTT CCGGCCATAC 
GGGCTCCACG GGGGCGAGCC TGGCGCCCGC GGCCTAAACC TGCTGATCCG CAAAAACGGC 
CGGACGGTGA ATCTGGGCGG CAAGACGTCG GTGACCGTGT ACCCCGGGGA TGTGTTCTGT 
CTCCACACGC CCGGCGGCGG TGGCTATGGG GACCCGGAGG ACCCCGCCCC ACCGCCGGGG 
TCGCCCCCGC AAGCACTGGC CTTTCCCGAG CACGGCAGCG TCTATGAGTA TCGCCGGGCC 
CAGGAGGCCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011515262.1
CDS	93..4247
Translation	MSLLSSYEGLRQEIQRLAQENEELRRLVQLIQENQELKLVLRNRGSSLGFCSSGFLAEVAASPWLPRRRTIKFKNAERVFPGLPAEELLWDSSPTTMGSPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYADAPTEGIRRILEQEAGMLLPRDQPLDSSHIASIRMGTTVATNALLERKGERVALLVTRGFRDLLHIGTQARGDLFDLAVPMPEVLYEEVLEVDERVVLHRGEAGTGTPVKGRTGDLLEVQQPVDLGALRGKLEGLLSRGIRSLAVVLMHSYTWAQHEQQVGVLARELGFTHVSLSSEAMPMVRIVPRGHTACADAYLTPAIQRYVQGFCRGFQGQLKDVQVLFMRSDGGLAPMDTFSGSSAVLSGPAGGVVGYSATTYQQEGGQPVIGFDMGGTSTDVSRYAGEFEHVFEASTAGVTLQAPQLDINTVAAGGGSRLFFRSGLFVVGPESAGAHPGPACYRKGGPVTVTDANLVLGRLLPASFPCIFGPGENQPLSPEASRKALEAVATEVNSFLTNGPCPASPLSLEEVAMGFVRVANEAMCRPIRALTQARGHDPSAHVLACFGGAGGQHACAIARALGMDTVHIHRHSGLLSALGLALADVVHEAQEPCSLLYAPETFVQLDQRLSRLEEQCVDALQAQGFPRSQISTESFLHLRYQGTDCALMVSAHQHPATARSPRAGDFGAAFVERYMREFGFVIPERPVVVDDVRVRGTGRSGLRLEDAPKAQTGPPRVDKMTQCYFEGGYQETPVYLLAELGYGHKLHGPCLIIDSNSTILVEPGCQAEVTKTGDICISVGAEVPGTVGPQLDPIQLSIFSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQFQIQHLGADLHPGDVLLSNHPSAGGSHLPDLTVITPVFWPGQTRPVFYVASRGHHADIGGITPGSMPPHSTMLQQEGAVFLSFKLVQGGVFQEEAVTEALRAPGKVPNCSGTRNLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYMGHIQANAELAVRDMLRAFGTSRQARGLPLEVSSEDHMDDGSPIRLRVQISLSQGSAVFDFSGTGPEVFGNLNAPRAVTLSALIYCLRCLVGRDIPLNQGCLAPVRVVIPRGSILDPSPEAAVVGGNVLTSQRVVDVILGAFGACAASQGCMNNVTLGNAHMGYYETVAGGAGAGPSWHGRSGVHSHMTNTRITDPEILESRYPVILRRFELRRGSGGRGRFRGGDGVTRELLFREEALLSVLTERRAFRPYGLHGGEPGARGLNLLIRKNGRTVNLGGKTSVTVYPGDVFCLHTPGGGGYGDPEDPAPPPGSPPQALAFPEHGSVYEYRRAQEAV

Target ORF information:

RefSeq Version	XM_011516960.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-oxoprolinase, ATP-hydrolysing (OPLAH), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516960.1

ORF Insert Sequence:

ATGTCCCTCC TCAGCAGCTA TGAGGGCCTG CGGCAGGAGA TCCAGCGGCT GGCACAGGAG 
AACGAAGAGC TGCGGCGGCT GGTGCAGCTC ATCCAGGAGA ACCAGGAGCT GAAGCTGGTG 
CTCAGGAACC GCGGCAGCAG CCTGGGCTTC TGCAGCTCCG GGTTCCTGGC TGAGGTGGCT 
GCCAGTCCCT GGCTACCCAG GCGGAGAACG ATCAAATTCA AGAATGCTGA GAGAGTTTTT 
CCAGGGCTAC CAGCTGAAGA GCTCCTGTGG GACTCCAGCC CCACCACCAT GGGCAGCCCC 
GAGGGCCGCT TCCACTTTGC CATCGACCGT GGGGGTACCT TCACAGACGT CTTTGCCCAG 
TGCCCAGGGG GGCACGTGCG GGTCTTAAAA CTGCTCTCAG AGGACCCTGC CAACTATGCG 
GACGCGCCAA CCGAAGGCAT CCGCCGCATC CTGGAGCAGG AGGCCGGCAT GCTCCTGCCC 
CGGGACCAGC CGCTGGACTC CAGTCATATC GCCAGCATCC GCATGGGCAC CACAGTGGCC 
ACCAACGCAC TGCTGGAGCG GAAGGGGGAG CGGGTGGCGC TGCTGGTGAC ACGTGGCTTC 
CGAGACCTGC TGCACATTGG CACCCAAGCC CGTGGGGACC TCTTTGACCT GGCCGTGCCC 
ATGCCTGAGG TGCTGTATGA AGAGGTGCTG GAGGTGGACG AACGCGTGGT GCTGCACCGT 
GGAGAGGCGG GCACCGGGAC GCCTGTGAAA GGCCGCACGG GGGACCTGCT GGAAGTGCAG 
CAGCCTGTGG ACCTGGGGGC CCTGCGTGGG AAGCTGGAGG GGCTGCTATC TCGAGGCATC 
CGCAGCCTGG CTGTGGTGCT CATGCACTCG TACACGTGGG CCCAGCATGA GCAGCAGGTG 
GGTGTGCTGG CCCGGGAGCT GGGCTTCACG CACGTGTCAC TGTCCTCGGA GGCCATGCCC 
ATGGTGCGCA TCGTCCCTCG GGGGCACACG GCCTGTGCCG ACGCCTACCT CACGCCCGCC 
ATCCAGCGCT ACGTGCAGGG CTTCTGCCGT GGCTTCCAGG GCCAACTCAA GGATGTGCAG 
GTGTTGTTCA TGCGCTCCGA TGGCGGCCTG GCGCCCATGG ACACCTTCAG CGGCTCCAGT 
GCTGTGCTCT CGGGCCCGGC CGGCGGCGTG GTGGGCTACT CAGCCACCAC CTACCAGCAG 
GAGGGTGGCC AGCCTGTCAT CGGCTTTGAC ATGGGAGGCA CGTCCACGGA TGTGAGCCGC 
TATGCTGGGG AATTCGAGCA CGTCTTCGAG GCCAGCACAG CTGGCGTCAC CCTCCAGGCC 
CCGCAGCTGG ACATCAACAC CGTGGCAGCG GGAGGGGGTT CCCGCCTCTT CTTCAGGTCT 
GGCCTCTTTG TGGTTGGGCC CGAGTCAGCA GGAGCCCACC CAGGACCCGC CTGCTACCGC 
AAAGGGGGCC CTGTGACAGT GACGGATGCT AATCTGGTCC TGGGTCGCCT GCTGCCTGCC 
TCCTTCCCCT GCATTTTTGG GCCGGGAGAG AACCAACCAC TTTCCCCTGA GGCCTCCCGC 
AAAGCCCTGG AGGCTGTGGC CACTGAGGTC AACAGCTTCC TGACCAACGG GCCCTGCCCG 
GCCTCCCCGC TGAGCCTGGA GGAGGTGGCC ATGGGGTTCG TGCGCGTGGC CAACGAGGCC 
ATGTGCCGGC CCATCCGTGC ACTCACGCAG GCAAGAGGCC ATGACCCCTC AGCCCATGTG 
CTGGCCTGCT TTGGGGGAGC TGGTGGGCAG CATGCATGTG CCATCGCCCG GGCCCTGGGC 
ATGGACACGG TGCACATCCA CAGGCACAGT GGGCTGCTGT CGGCCCTGGG GCTGGCCCTG 
GCTGACGTGG TGCATGAGGC ACAGGAACCC TGCTCCCTGC TCTACGCGCC TGAGACCTTC 
GTGCAGCTGG ACCAGAGGCT GAGCCGCCTG GAGGAGCAGT GTGTGGATGC TCTGCAGGCC 
CAGGGCTTCC CCAGGTCCCA GATCAGCACT GAGAGCTTCC TGCACCTGCG CTACCAGGGC 
ACGGACTGTG CTCTGATGGT GTCTGCCCAC CAGCACCCAG CCACAGCCCG CTCGCCCCGT 
GCGGGGGACT TCGGGGCAGC CTTTGTGGAG CGGTACATGA GGGAGTTTGG CTTTGTCATA 
CCTGAGCGGC CGGTGGTCGT GGACGATGTG CGAGTGCGGG GCACCGGCCG CAGTGGTCTT 
CGCCTCGAGG ATGCCCCCAA AGCCCAGACC GGGCCTCCCC GGGTGGACAA GATGACCCAG 
TGCTACTTTG AGGGGGGCTA CCAGGAGACC CCTGTGTACC TGCTGGCAGA GCTGGGCTAT 
GGGCACAAGC TCCATGGGCC CTGCCTCATC ATCGACAGTA ACAGCACCAT CCTGGTGGAG 
CCAGGTTGCC AGGCAGAGGT GACCAAGACA GGGGACATCT GCATCTCCGT GGGGGCCGAA 
GTCCCCGGCA CAGTGGGCCC CCAGCTGGAC CCTATCCAGC TGTCCATCTT CTCACACCGC 
TTCATGAGCA TTGCTGAGCA GATGGGCCGC ATCCTGCAGC GCACAGCCAT CTCCACCAAC 
ATCAAGGAGC GTCTGGACTT CTCCTGTGCC CTCTTTGGGC CCGATGGGGG GCTGGTGTCC 
AATGCCCCCC ACATCCCTGT GCACCTGGGT GCCATGCAGG AGACGGTGCA GTTCCAGATT 
CAGCACCTGG GGGCCGATCT CCACCCTGGC GACGTGCTAC TGAGCAACCA TCCCAGTGCC 
GGGGGCAGCC ACCTGCCAGA CCTGACTGTT ATCACACCGG TGTTTTGGCC GGGTCAGACG 
CGGCCTGTGT TCTATGTGGC CAGCCGAGGG CACCACGCAG ACATCGGGGG CATCACACCA 
GGCTCCATGC CCCCCCACTC CACCATGCTG CAACAGGAGG GTGCCGTCTT TCTGTCCTTC 
AAACTTGTCC AGGGGGGCGT CTTCCAGGAG GAGGCGGTGA CGGAGGCCCT GCGGGCGCCA 
GGCAAGGTCC CCAACTGCAG CGGAACCAGA AACCTGCACG ACAACCTGTC GGACCTCCGT 
GCCCAGGTGG CAGCCAACCA GAAGGGCATC CAGCTGGTGG GGGAGCTCAT TGGGCAGTAC 
GGCCTGGACG TGGTGCAGGC CTACATGGGC CATATTCAGG CAAACGCTGA GCTGGCCGTG 
CGAGACATGT TGCGTGCCTT TGGAACCTCC CGGCAGGCCC GGGGCCTGCC CCTGGAGGTG 
TCCTCGGAAG ACCACATGGA CGACGGTTCC CCCATCCGCC TCCGTGTGCA GATCAGCCTG 
AGTCAGGGCA GCGCCGTGTT TGACTTCAGC GGCACTGGGC CGGAGGTGTT TGGTAATCTC 
AACGCACCGC GGGCCGTAAC CCTGTCCGCC CTCATCTACT GCCTGCGCTG TCTGGTGGGC 
CGCGACATCC CACTCAACCA GGGCTGCCTG GCGCCAGTGC GCGTGGTCAT TCCCCGAGGC 
TCCATCCTGG ACCCGTCGCC CGAGGCGGCG GTGGTGGGCG GCAACGTGCT CACGTCGCAG 
CGCGTGGTGG ATGTCATCCT GGGGGCCTTT GGGGCCTGCG CCGCCTCCCA GGGCTGCATG 
AACAACGTGA CCCTGGGCAA CGCCCACATG GGCTACTACG AGACGGTGGC GGGCGGCGCG 
GGCGCGGGTC CCAGCTGGCA CGGGCGCAGC GGTGTGCACA GCCACATGAC CAACACACGC 
ATCACCGACC CTGAGATCCT GGAGAGCCGG TACCCGGTCA TCCTGCGCCG CTTCGAGCTG 
CGGCGGGGCT CGGGGGGCAG AGGCCGCTTC CGAGGCGGCG ACGGCGTCAC CCGCGAGCTG 
CTCTTTCGTG AGGAGGCGCT GCTGTCAGTG CTGACCGAGC GCCGCGCCTT CCGGCCATAC 
GGGCTCCACG GGGGCGAGCC TGGCGCCCGC GGCCTAAACC TGCTGATCCG CAAAAACGGC 
CGGACGGTGA ATCTGGGCGG CAAGACGTCG GTGACCGTGT ACCCCGGGGA TGTGTTCTGT 
CTCCACACGC CCGGCGGCGG TGGCTATGGG GACCCGGAGG ACCCCGCCCC ACCGCCGGGG 
TCGCCCCCGC AAGCACTGGC CTTTCCCGAG CACGGCAGCG TCTATGAGTA TCGCCGGGCC 
CAGGAGGCCG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Unravelling 5-oxoprolinuria (pyroglutamic aciduria) due to bi-allelic OPLAH mutations: 20 new mutations in 14 families.
Molecular genetics and metabolism119(1-2)44-9(2016 09)
Sass JO,Gemperle-Britschgi C,Tarailo-Graovac M,Patel N,Walter M,Jordanova A,Alfadhel M,Bari? I,?oker M,Damli-Huber A,Faqeih EA,Garc?a Segarra N,Geraghty MT,J?tun BM,Kalkan U?ar S,Kriewitz M,Rauchenzauner M,Bili? K,Tournev I,Till C,Sayson B,Beumer D,Ye CX,Zhang LH,Vallance H,Alkuraya FS,van Karnebeek CD

Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies.
Brain & development37(10)952-9(2015 Nov)
Li X,Ding Y,Liu Y,Ma Y,Song J,Wang Q,Yang Y

An atlas of genetic influences on human blood metabolites.
Nature genetics46(6)543-550(2014 Jun)
Shin SY,Fauman EB,Petersen AK,Krumsiek J,Santos R,Huang J,Arnold M,Erte I,Forgetta V,Yang TP,Walter K,Menni C,Chen L,Vasquez L,Valdes AM,Hyde CL,Wang V,Ziemek D,Roberts P,Xi L,Grundberg E,,Waldenberger M,Richards JB,Mohney RP,Milburn MV,John SL,Trimmer J,Theis FJ,Overington JP,Suhre K,Brosnan MJ,Gieger C,Kastenm?ller G,Spector TD,Soranzo N

5-Oxoprolinuria in Heterozygous Patients for 5-Oxoprolinase (OPLAH) Missense Changes.
JIMD reports7123-8(2013)
Calpena E,Casado M,Mart?nez-Rubio D,Nascimento A,Colomer J,Gargallo E,Garc?a-Cazorla A,Palau F,Artuch R,Espin?s C

Human metabolic individuality in biomedical and pharmaceutical research.
Nature477(7362)54-60(2011 Aug)
Suhre K,Shin SY,Petersen AK,Mohney RP,Meredith D,W?gele B,Altmaier E,,Deloukas P,Erdmann J,Grundberg E,Hammond CJ,de Angelis MH,Kastenm?ller G,K?ttgen A,Kronenberg F,Mangino M,Meisinger C,Meitinger T,Mewes HW,Milburn MV,Prehn C,Raffler J,Ried JS,R?misch-Margl W,Samani NJ,Small KS,Wichmann HE,Zhai G,Illig T,Spector TD,Adamski J,Soranzo N,Gieger C

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OPLAH cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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