B4GALT1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	B4GALT1
Entrez Gene ID	2683
Full Name	beta-1,4-galactosyltransferase 1
Synonyms	B4GAL-T1,CDG2D,GGTB2,GT1,GTB,beta4Gal-T1
General protein information	Preferred Names beta-1,4-galactosyltransferase 1 Names beta-1,4-galactosyltransferase 1 UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1 beta-1,4-GalTase 1 glycoprotein-4-beta-galactosyltransferase 2 lactose synthase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.1
Summary	This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008].
Disorder MIM:	137060
Disorder Html:	Congenital disorder of glycosylation, type IId, 607091 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005251440.5	XP_005251497.1	beta-1,4-galactosyltransferase 1 isoform X1
XM_005251440.4	XP_005251497.1	beta-1,4-galactosyltransferase 1 isoform X1
NM_001497.3	NP_001488.2	beta-1,4-galactosyltransferase 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	B4GALT1	XP_003312085.1
Bos taurus (cattle)	B4GALT1	NP_803478.1
Rattus norvegicus (Norway rat)	B4galt1	NP_445739.1
Gallus gallus (chicken)	B4GALT1	NP_990533.1
Mus musculus (house mouse)	B4galt1	NP_071641.1
Danio rerio (zebrafish)	zgc:154116	NP_001070727.2
Xenopus tropicalis (tropical clawed frog)	b4galt1.2	NP_001016664.1
Homo sapiens (human)	B4GALT1	NP_001488.2
	B4GALT1	XP_001100938.1
Canis lupus familiaris (dog)	B4GALT1	XP_538701.3
Xenopus tropicalis (tropical clawed frog)	b4galt1.1	NP_001120432.1

Gene Ontology
Bibliography

Related articles in PubMed

?1,4-galactosyltransferase 1 is a novel receptor for IgA in human mesangial cells.
Molyneux K, Wimbury D, Pawluczyk I, Muto M, Bhachu J, Mertens PR, Feehally J, Barratt J
Kidney international92(6)1458-1468(2017 Dec)

ZFX modulates the growth of human leukemic cells via B4GALT1.
Wu J, Xiao L, Zhou H, Liu H, Ge Y, Yang J, Li Y, Wu D, Zhao Y, Zhang X
Acta biochimica et biophysica Sinica48(12)1120-1127(2016 Dec)

Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.
Xie H, Zhu Y, An H, Wang H, Zhu Y, Fu H, Wang Z, Fu Q, Xu J, Ye D
Oncotarget7(22)32723-30(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

demonstrated that ZFX is aberrantly expressed in multiple human leukemic cells and it modulates the growth and drug response of leukemic cells partially via B4GALT1, which suggests that ZFX is a new regulator of leukemic cells and warrants intensive investigations on this 'stemness' regulator in these deadly diseases
Title: ZFX modulates the growth of human leukemic cells via B4GALT1.

Increased B4GALT1 expression is a potential independent adverse prognostic factor for overall survival in patients with non-metastatic clear cell renal cell carcinoma.
Title: Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.

High B4GALT1 expression is associated with aging.
Title: Identification of novel plasma glycosylation-associated markers of aging.

We suggest that the unique expression patterns for the B4GALT1 in normal and malignant tissues are controlled by a differential usage of 5'-B4GALT1 regulatory units along with a post-transcriptional regulation by the antisense RNA
Title: Multifaceted roles of 5'-regulatory region of the cancer associated gene B4GALT1 and its comparison with the gene family.

Human chorionic gonadotropin provides a mechanism to bridge embryo to endometrium through beta1,4-GalT.
Title: HCG induces ?1,4-GalT I expression and promotes embryo implantation.

The following B4GALT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the B4GALT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19629	NM_001497.3 Latest version!	Homo sapiens beta-1,4-galactosyltransferase 1 (B4GALT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu42707	XM_005251440.5 Latest version!	Homo sapiens beta-1,4-galactosyltransferase 1 (B4GALT1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu42707	XM_005251440.4	Homo sapiens beta-1,4-galactosyltransferase 1 (B4GALT1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

B4GALT1 ( NM_001497.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001488.2 Homo sapiens beta-1,4-galactosyltransferase 1 (B4GALT1), mRNA.

Price & Availability↑

CloneID	OHu19629
Clone ID Related Accession (Same CDS sequence)	NM_001497.3
Accession Version	NM_001497.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	beta-1,4-galactosyltransferase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL161445.10, X55415.1, M13701.1 and BU624063.1. This sequence is a reference standard in the RefSeqGene project. On Jun 29, 2008 this sequence version replaced NM_001497.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D29805.1, SRR1660803.241465.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGCTTC GGGAGCCGCT CCTGAGCGGC AGCGCCGCGA TGCCAGGCGC GTCCCTACAG 
CGGGCCTGCC GCCTGCTCGT GGCCGTCTGC GCTCTGCACC TTGGCGTCAC CCTCGTTTAC 
TACCTGGCTG GCCGCGACCT GAGCCGCCTG CCCCAACTGG TCGGAGTCTC CACACCGCTG 
CAGGGCGGCT CGAACAGTGC CGCCGCCATC GGGCAGTCCT CCGGGGAGCT CCGGACCGGA 
GGGGCCCGGC CGCCGCCTCC TCTAGGCGCC TCCTCCCAGC CGCGCCCGGG TGGCGACTCC 
AGCCCAGTCG TGGATTCTGG CCCTGGCCCC GCTAGCAACT TGACCTCGGT CCCAGTGCCC 
CACACCACCG CACTGTCGCT GCCCGCCTGC CCTGAGGAGT CCCCGCTGCT TGTGGGCCCC 
ATGCTGATTG AGTTTAACAT GCCTGTGGAC CTGGAGCTCG TGGCAAAGCA GAACCCAAAT 
GTGAAGATGG GCGGCCGCTA TGCCCCCAGG GACTGCGTCT CTCCTCACAA GGTGGCCATC 
ATCATTCCAT TCCGCAACCG GCAGGAGCAC CTCAAGTACT GGCTATATTA TTTGCACCCA 
GTCCTGCAGC GCCAGCAGCT GGACTATGGC ATCTATGTTA TCAACCAGGC GGGAGACACT 
ATATTCAATC GTGCTAAGCT CCTCAATGTT GGCTTTCAAG AAGCCTTGAA GGACTATGAC 
TACACCTGCT TTGTGTTTAG TGACGTGGAC CTCATTCCAA TGAATGACCA TAATGCGTAC 
AGGTGTTTTT CACAGCCACG GCACATTTCC GTTGCAATGG ATAAGTTTGG ATTCAGCCTA 
CCTTATGTTC AGTATTTTGG AGGTGTCTCT GCTCTAAGTA AACAACAGTT TCTAACCATC 
AATGGATTTC CTAATAATTA TTGGGGCTGG GGAGGAGAAG ATGATGACAT TTTTAACAGA 
TTAGTTTTTA GAGGCATGTC TATATCTCGC CCAAATGCTG TGGTCGGGAG GTGTCGCATG 
ATCCGCCACT CAAGAGACAA GAAAAATGAA CCCAATCCTC AGAGGTTTGA CCGAATTGCA 
CACACAAAGG AGACAATGCT CTCTGATGGT TTGAACTCAC TCACCTACCA GGTGCTGGAT 
GTACAGAGAT ACCCATTGTA TACCCAAATC ACAGTGGACA TCGGGACACC GAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001488.2
CDS	190..1386
Translation	MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPLQGGSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYDYTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLTINGFPNNYWGWGGEDDDIFNRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS

Target ORF information:

RefSeq Version	NM_001497.3
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-1,4-galactosyltransferase 1 (B4GALT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001497.3

ORF Insert Sequence:

ATGAGGCTTC GGGAGCCGCT CCTGAGCGGC AGCGCCGCGA TGCCAGGCGC GTCCCTACAG 
CGGGCCTGCC GCCTGCTCGT GGCCGTCTGC GCTCTGCACC TTGGCGTCAC CCTCGTTTAC 
TACCTGGCTG GCCGCGACCT GAGCCGCCTG CCCCAACTGG TCGGAGTCTC CACACCGCTG 
CAGGGCGGCT CGAACAGTGC CGCCGCCATC GGGCAGTCCT CCGGGGAGCT CCGGACCGGA 
GGGGCCCGGC CGCCGCCTCC TCTAGGCGCC TCCTCCCAGC CGCGCCCGGG TGGCGACTCC 
AGCCCAGTCG TGGATTCTGG CCCTGGCCCC GCTAGCAACT TGACCTCGGT CCCAGTGCCC 
CACACCACCG CACTGTCGCT GCCCGCCTGC CCTGAGGAGT CCCCGCTGCT TGTGGGCCCC 
ATGCTGATTG AGTTTAACAT GCCTGTGGAC CTGGAGCTCG TGGCAAAGCA GAACCCAAAT 
GTGAAGATGG GCGGCCGCTA TGCCCCCAGG GACTGCGTCT CTCCTCACAA GGTGGCCATC 
ATCATTCCAT TCCGCAACCG GCAGGAGCAC CTCAAGTACT GGCTATATTA TTTGCACCCA 
GTCCTGCAGC GCCAGCAGCT GGACTATGGC ATCTATGTTA TCAACCAGGC GGGAGACACT 
ATATTCAATC GTGCTAAGCT CCTCAATGTT GGCTTTCAAG AAGCCTTGAA GGACTATGAC 
TACACCTGCT TTGTGTTTAG TGACGTGGAC CTCATTCCAA TGAATGACCA TAATGCGTAC 
AGGTGTTTTT CACAGCCACG GCACATTTCC GTTGCAATGG ATAAGTTTGG ATTCAGCCTA 
CCTTATGTTC AGTATTTTGG AGGTGTCTCT GCTCTAAGTA AACAACAGTT TCTAACCATC 
AATGGATTTC CTAATAATTA TTGGGGCTGG GGAGGAGAAG ATGATGACAT TTTTAACAGA 
TTAGTTTTTA GAGGCATGTC TATATCTCGC CCAAATGCTG TGGTCGGGAG GTGTCGCATG 
ATCCGCCACT CAAGAGACAA GAAAAATGAA CCCAATCCTC AGAGGTTTGA CCGAATTGCA 
CACACAAAGG AGACAATGCT CTCTGATGGT TTGAACTCAC TCACCTACCA GGTGCTGGAT 
GTACAGAGAT ACCCATTGTA TACCCAAATC ACAGTGGACA TCGGGACACC GAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

B4GALT1 ( XM_005251440.5 ) cDNA ORF clone, Homo sapiens(human) -> XP_005251497.1 Homo sapiens beta-1,4-galactosyltransferase 1 (B4GALT1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu42707
Clone ID Related Accession (Same CDS sequence)	XM_005251440.5 , XM_005251440.4
Accession Version	XM_005251440.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	beta-1,4-galactosyltransferase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005251440.4. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGCTTC GGGAGCCGCT CCTGAGCGGC AGCGCCGCGA TGCCAGGCGC GTCCCTACAG 
CGGGCCTGCC GCCTGCTCGT GGCCGTCTGC GCTCTGCACC TTGGCGTCAC CCTCGTTTAC 
TACCTGGCTG GCCGCGACCT GAGCCGCCTG CCCCAACTGG TCGGAGTCTC CACACCGCTG 
CAGGGCGGCT CGAACAGTGC CGCCGCCATC GGGCAGTCCT CCGGGGAGCT CCGGACCGGA 
GGGGCCCGGC CGCCGCCTCC TCTAGGCGCC TCCTCCCAGC CGCGCCCGGG TGGCGACTCC 
AGCCCAGTCG TGGATTCTGG CCCTGGCCCC GCTAGCAACT TGACCTCGGT CCCAGTGCCC 
CACACCACCG CACTGTCGCT GCCCGCCTGC CCTGAGGAGT CCCCGCTGCT TGTGGGCCCC 
ATGCTGATTG AGTTTAACAT GCCTGTGGAC CTGGAGCTCG TGGCAAAGCA GAACCCAAAT 
GTGAAGATGG GCGGCCGCTA TGCCCCCAGG GACTGCGTCT CTCCTCACAA GGTGGCCATC 
ATCATTCCAT TCCGCAACCG GCAGGAGCAC CTCAAGTACT GGCTATATTA TTTGCACCCA 
GTCCTGCAGC GCCAGCAGCT GGACTATGGC ATCTATGTTA TCAACCAGGC GGGAGACACT 
ATATTCAATC GTGCTAAGCT CCTCAATGTT GGCTTTCAAG AAGCCTTGAA GGACTATGAC 
TACACCTGCT TTGTGTTTAG TGACGTGGAC CTCATTCCAA TGAATGACCA TAATGCGTAC 
AGGTGTTTTT CACAGCCACG GCACATTTCC GTTGCAATGG ATAAGTTTGG ATTCAGATTA 
GTTTTTAGAG GCATGTCTAT ATCTCGCCCA AATGCTGTGG TCGGGAGGTG TCGCATGATC 
CGCCACTCAA GAGACAAGAA AAATGAACCC AATCCTCAGA GGTTTGACCG AATTGCACAC 
ACAAAGGAGA CAATGCTCTC TGATGGTTTG AACTCACTCA CCTACCAGGT GCTGGATGTA 
CAGAGATACC CATTGTATAC CCAAATCACA GTGGACATCG GGACACCGAG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005251497.1
CDS	29..1102
Translation	MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPLQGGSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYDYTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS

Target ORF information:

RefSeq Version	XM_005251440.5
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-1,4-galactosyltransferase 1 (B4GALT1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005251440.5

ORF Insert Sequence:

ATGAGGCTTC GGGAGCCGCT CCTGAGCGGC AGCGCCGCGA TGCCAGGCGC GTCCCTACAG 
CGGGCCTGCC GCCTGCTCGT GGCCGTCTGC GCTCTGCACC TTGGCGTCAC CCTCGTTTAC 
TACCTGGCTG GCCGCGACCT GAGCCGCCTG CCCCAACTGG TCGGAGTCTC CACACCGCTG 
CAGGGCGGCT CGAACAGTGC CGCCGCCATC GGGCAGTCCT CCGGGGAGCT CCGGACCGGA 
GGGGCCCGGC CGCCGCCTCC TCTAGGCGCC TCCTCCCAGC CGCGCCCGGG TGGCGACTCC 
AGCCCAGTCG TGGATTCTGG CCCTGGCCCC GCTAGCAACT TGACCTCGGT CCCAGTGCCC 
CACACCACCG CACTGTCGCT GCCCGCCTGC CCTGAGGAGT CCCCGCTGCT TGTGGGCCCC 
ATGCTGATTG AGTTTAACAT GCCTGTGGAC CTGGAGCTCG TGGCAAAGCA GAACCCAAAT 
GTGAAGATGG GCGGCCGCTA TGCCCCCAGG GACTGCGTCT CTCCTCACAA GGTGGCCATC 
ATCATTCCAT TCCGCAACCG GCAGGAGCAC CTCAAGTACT GGCTATATTA TTTGCACCCA 
GTCCTGCAGC GCCAGCAGCT GGACTATGGC ATCTATGTTA TCAACCAGGC GGGAGACACT 
ATATTCAATC GTGCTAAGCT CCTCAATGTT GGCTTTCAAG AAGCCTTGAA GGACTATGAC 
TACACCTGCT TTGTGTTTAG TGACGTGGAC CTCATTCCAA TGAATGACCA TAATGCGTAC 
AGGTGTTTTT CACAGCCACG GCACATTTCC GTTGCAATGG ATAAGTTTGG ATTCAGATTA 
GTTTTTAGAG GCATGTCTAT ATCTCGCCCA AATGCTGTGG TCGGGAGGTG TCGCATGATC 
CGCCACTCAA GAGACAAGAA AAATGAACCC AATCCTCAGA GGTTTGACCG AATTGCACAC 
ACAAAGGAGA CAATGCTCTC TGATGGTTTG AACTCACTCA CCTACCAGGT GCTGGATGTA 
CAGAGATACC CATTGTATAC CCAAATCACA GTGGACATCG GGACACCGAG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

B4GALT1 ( XM_005251440.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005251497.1 Homo sapiens beta-1,4-galactosyltransferase 1 (B4GALT1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu42707
Clone ID Related Accession (Same CDS sequence)	XM_005251440.5 , XM_005251440.4
Accession Version	XM_005251440.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	beta-1,4-galactosyltransferase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005251440.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGCTTC GGGAGCCGCT CCTGAGCGGC AGCGCCGCGA TGCCAGGCGC GTCCCTACAG 
CGGGCCTGCC GCCTGCTCGT GGCCGTCTGC GCTCTGCACC TTGGCGTCAC CCTCGTTTAC 
TACCTGGCTG GCCGCGACCT GAGCCGCCTG CCCCAACTGG TCGGAGTCTC CACACCGCTG 
CAGGGCGGCT CGAACAGTGC CGCCGCCATC GGGCAGTCCT CCGGGGAGCT CCGGACCGGA 
GGGGCCCGGC CGCCGCCTCC TCTAGGCGCC TCCTCCCAGC CGCGCCCGGG TGGCGACTCC 
AGCCCAGTCG TGGATTCTGG CCCTGGCCCC GCTAGCAACT TGACCTCGGT CCCAGTGCCC 
CACACCACCG CACTGTCGCT GCCCGCCTGC CCTGAGGAGT CCCCGCTGCT TGTGGGCCCC 
ATGCTGATTG AGTTTAACAT GCCTGTGGAC CTGGAGCTCG TGGCAAAGCA GAACCCAAAT 
GTGAAGATGG GCGGCCGCTA TGCCCCCAGG GACTGCGTCT CTCCTCACAA GGTGGCCATC 
ATCATTCCAT TCCGCAACCG GCAGGAGCAC CTCAAGTACT GGCTATATTA TTTGCACCCA 
GTCCTGCAGC GCCAGCAGCT GGACTATGGC ATCTATGTTA TCAACCAGGC GGGAGACACT 
ATATTCAATC GTGCTAAGCT CCTCAATGTT GGCTTTCAAG AAGCCTTGAA GGACTATGAC 
TACACCTGCT TTGTGTTTAG TGACGTGGAC CTCATTCCAA TGAATGACCA TAATGCGTAC 
AGGTGTTTTT CACAGCCACG GCACATTTCC GTTGCAATGG ATAAGTTTGG ATTCAGATTA 
GTTTTTAGAG GCATGTCTAT ATCTCGCCCA AATGCTGTGG TCGGGAGGTG TCGCATGATC 
CGCCACTCAA GAGACAAGAA AAATGAACCC AATCCTCAGA GGTTTGACCG AATTGCACAC 
ACAAAGGAGA CAATGCTCTC TGATGGTTTG AACTCACTCA CCTACCAGGT GCTGGATGTA 
CAGAGATACC CATTGTATAC CCAAATCACA GTGGACATCG GGACACCGAG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005251497.1
CDS	223..1296
Translation	MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPLQGGSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYDYTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS

Target ORF information:

RefSeq Version	XM_005251440.4
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-1,4-galactosyltransferase 1 (B4GALT1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005251440.4

ORF Insert Sequence:

ATGAGGCTTC GGGAGCCGCT CCTGAGCGGC AGCGCCGCGA TGCCAGGCGC GTCCCTACAG 
CGGGCCTGCC GCCTGCTCGT GGCCGTCTGC GCTCTGCACC TTGGCGTCAC CCTCGTTTAC 
TACCTGGCTG GCCGCGACCT GAGCCGCCTG CCCCAACTGG TCGGAGTCTC CACACCGCTG 
CAGGGCGGCT CGAACAGTGC CGCCGCCATC GGGCAGTCCT CCGGGGAGCT CCGGACCGGA 
GGGGCCCGGC CGCCGCCTCC TCTAGGCGCC TCCTCCCAGC CGCGCCCGGG TGGCGACTCC 
AGCCCAGTCG TGGATTCTGG CCCTGGCCCC GCTAGCAACT TGACCTCGGT CCCAGTGCCC 
CACACCACCG CACTGTCGCT GCCCGCCTGC CCTGAGGAGT CCCCGCTGCT TGTGGGCCCC 
ATGCTGATTG AGTTTAACAT GCCTGTGGAC CTGGAGCTCG TGGCAAAGCA GAACCCAAAT 
GTGAAGATGG GCGGCCGCTA TGCCCCCAGG GACTGCGTCT CTCCTCACAA GGTGGCCATC 
ATCATTCCAT TCCGCAACCG GCAGGAGCAC CTCAAGTACT GGCTATATTA TTTGCACCCA 
GTCCTGCAGC GCCAGCAGCT GGACTATGGC ATCTATGTTA TCAACCAGGC GGGAGACACT 
ATATTCAATC GTGCTAAGCT CCTCAATGTT GGCTTTCAAG AAGCCTTGAA GGACTATGAC 
TACACCTGCT TTGTGTTTAG TGACGTGGAC CTCATTCCAA TGAATGACCA TAATGCGTAC 
AGGTGTTTTT CACAGCCACG GCACATTTCC GTTGCAATGG ATAAGTTTGG ATTCAGATTA 
GTTTTTAGAG GCATGTCTAT ATCTCGCCCA AATGCTGTGG TCGGGAGGTG TCGCATGATC 
CGCCACTCAA GAGACAAGAA AAATGAACCC AATCCTCAGA GGTTTGACCG AATTGCACAC 
ACAAAGGAGA CAATGCTCTC TGATGGTTTG AACTCACTCA CCTACCAGGT GCTGGATGTA 
CAGAGATACC CATTGTATAC CCAAATCACA GTGGACATCG GGACACCGAG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

?1,4-galactosyltransferase 1 is a novel receptor for IgA in human mesangial cells.
Kidney international92(6)1458-1468(2017 Dec)
Molyneux K,Wimbury D,Pawluczyk I,Muto M,Bhachu J,Mertens PR,Feehally J,Barratt J

ZFX modulates the growth of human leukemic cells via B4GALT1.
Acta biochimica et biophysica Sinica48(12)1120-1127(2016 Dec)
Wu J,Xiao L,Zhou H,Liu H,Ge Y,Yang J,Li Y,Wu D,Zhao Y,Zhang X

Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.
Oncotarget7(22)32723-30(2016 May)
Xie H,Zhu Y,An H,Wang H,Zhu Y,Fu H,Wang Z,Fu Q,Xu J,Ye D

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B4GALT1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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