PGBD3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PGBD3
Entrez Gene ID	267004
Full Name	piggyBac transposable element derived 3
General protein information	Preferred Names piggyBac transposable element derived 3 Names piggyBac transposable element-derived protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q11.23
Summary	This gene is a member of a small family of genes derived from piggyBac transposable elements. The encoded protein contains a zinc-ribbon domain characteristic of transposon-derived proteins and may function as a regulator of transcription. Alternative splicing occurs between a splice site from exon 5 of the adjacent upstream gene 'excision repair cross-complementation group 6' (ERCC6, GeneID: 2074) and the 3' splice site upstream of the open reading frame (ORF) of this gene, which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. Pseudogenes for this gene are defined on chromosomes 4, 5 and 12. [provided by RefSeq, Mar 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_170753.3	NP_736609.2	piggyBac transposable element-derived protein 3

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

What role (if any) does the highly conserved CSB-PGBD3 fusion protein play in Cockayne syndrome?
Weiner AM, Gray LT
Mechanisms of ageing and development134(5-6)225-33(2013 May-Jun)

Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans.
Gray LT, Fong KK, Pavelitz T, Weiner AM
PLoS genetics8(9)e1002972(2012 Sep)

The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.
Bailey AD, Gray LT, Pavelitz T, Newman JC, Horibata K, Tanaka K, Weiner AM
DNA repair11(5)488-501(2012 May)

Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex.
Horibata K, Saijo M, Bay MN, Lan L, Kuraoka I, Brooks PJ, Honma M, Nohmi T, Yasui A, Tanaka K
Genes to cells : devoted to molecular & cellular mechanisms16(1)101-14(2011 Jan)

An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.
Newman JC, Bailey AD, Fan HY, Pavelitz T, Weiner AM
PLoS genetics4(3)e1000031(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CSB-PGBD3 fusion protein is important in both health and disease, and could play a role in Cockayne syndrome.
Title: The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

a domesticated PiggyBac-like transposon PGBD3, residing within intron 5 of the CSB gene, functions as an alternative 3' terminal exon
Title: An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.

Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

The following PGBD3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PGBD3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu20776	NM_170753.3 Latest version!	Homo sapiens piggyBac transposable element derived 3 (PGBD3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PGBD3 ( NM_170753.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_736609.2 Homo sapiens piggyBac transposable element derived 3 (PGBD3), mRNA.

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CloneID	OHu20776
Clone ID Related Accession (Same CDS sequence)	NM_170753.3
Accession Version	NM_170753.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	piggyBac transposable element-derived protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Hugh Robertson. The reference sequence was derived from BC063690.1 and AL138760.14. This sequence is a reference standard in the RefSeqGene project. On Mar 4, 2013 this sequence version replaced NM_170753.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC063690.1, SRR1660809.197215.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTCGAA CACTAAGTTT ACATGAAATA ACTGACCTTT TAGAGACAGA TGACAGCATA 
GAAGCAAGTG CTATAGTGAT ACAACCACCT GAAAATGCTA CAGCACCTGT TTCTGATGAG 
GAATCAGGAG ATGAAGAAGG TGGAACAATA AATAATCTGC CAGGTTCTTT GTTGCACACA 
GCTGCGTATC TTATTCAAGA TGGCTCTGAT GCTGAGTCTG ACTCAGATGA TCCCTCATAC 
GCACCTAAAG ATGACTCTCC TGATGAAGTT CCATCTACGT TTACTGTGCA GCAACCTCCA 
CCATCAAGGA GGAGGAAAAT GACAAAAATT CTTTGCAAAT GGAAAAAAGC CGACCTAACT 
GTACAACCCG TAGCAGGTAG AGTTACAGCA CCACCAAACG ATTTCTTCAC CGTAATGAGA 
ACTCCCACAG AAATTCTTGA ACTTTTTCTT GATGACGAGG TCATTGAACT CATTGTCAAG 
TACTCCAACT TATATGCTTG CAGTAAAGGT GTACATCTTG GCTTGACTAG CTCTGAATTC 
AAATGTTTTC TGGGAATTAT TTTTCTGAGT GGTTATGTCT CAGTTCCTAG AAGGCGTATG 
TTTTGGGAAC AAAGAACAGA TGTGCATAAT GTACTGGTTA GTGCTGCCAT GAGACGTGAC 
CGGTTTGAAA CTATATTTTC TAATTTGCAT GTTGCTGACA ATGCAAATTT GGATCCAGTG 
GACAAATTTT CCAAATTGCG ACCTCTCATA AGCAAACTTA ATGAGAGATG CATGAAATTT 
GTTCCAAATG AAACATATTT CAGCTTTGAT GAATTCATGG TTCCTTATTT TGGTCGTCAC 
GGGTGCAAAC AATTTATTCG GGGAAAGCCC ATTCGGTTTG GCTATAAGTT TTGGTGTGGT 
GCCACCTGTC TGGGCTACAT TTGCTGGTTT CAGCCGTATC AGGGTAAAAA CCCAAATACT 
AAACATGAGG AATATGGTGT CGGTGCGTCA CTTGTCCTTC AGTTTAGTGA GGCACTTACA 
GAGGCACACC CTGGACAATA CCATTTTGTA TTCAATAACT TTTTCACCAG TATTGCACTT 
CTTGATAAGC TCAGTTCAAT GGGACATCAG GCAACAGGTA CAGTGAGAAA GGATCACATT 
GACAGAGTTC CACTGGAATC AGATGTAGCT TTAAAGAAAA AAGAAAGAGG CACATTTGAT 
TATCGAATTG ATGGCAAAGG CAATATTGTC TGCAGATGGA ATGATAACAG TGTTGTCACT 
GTTGCCTCAT CTGGTGCTGG TATCCATCCC CTGTGTCTTG TCAGTCGTTA CTCCCAGAAA 
CTGAAAAAGA AGATACAAGT TCAGCAGCCA AACATGATCA AAGTGTATAA CCAGTTCATG 
GGAGGCGTAG ACAGAGCTGA TGAAAACATT GATAAGTATC GGGCATCAAT CCGTGGAAAG 
AAATGGTATT CAAGCCCTCT TTTGTTCTGT TTCGAACTGG TCTTACAAAA TGCTTGGCAA 
TTGCATAAAA CATATGATGA GAAACCAGTG GATTTTCTGG AGTTTCGTCG ACGTGTGGTA 
TGCCATTATC TGGAGACCCA TGGTCATCCT CCAGAACCTG GCCAAAAAGG AAGACCTCAG 
AAGCGTAACA TTGACTCACG TTATGATGGC ATAAATCATG TGATAGTCAA ACAGGGAAAG 
CAAACGCGAT GCGCTGAATG TCATAAGAAC ACAACTTTTC GATGTGAAAA ATGTGATGTT 
GCCTTACATG TGAAGTGTTC CGTTGAATAT CACACTGAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_736609.2
CDS	257..2038
Translation	MPRTLSLHEITDLLETDDSIEASAIVIQPPENATAPVSDEESGDEEGGTINNLPGSLLHTAAYLIQDGSDAESDSDDPSYAPKDDSPDEVPSTFTVQQPPPSRRRKMTKILCKWKKADLTVQPVAGRVTAPPNDFFTVMRTPTEILELFLDDEVIELIVKYSNLYACSKGVHLGLTSSEFKCFLGIIFLSGYVSVPRRRMFWEQRTDVHNVLVSAAMRRDRFETIFSNLHVADNANLDPVDKFSKLRPLISKLNERCMKFVPNETYFSFDEFMVPYFGRHGCKQFIRGKPIRFGYKFWCGATCLGYICWFQPYQGKNPNTKHEEYGVGASLVLQFSEALTEAHPGQYHFVFNNFFTSIALLDKLSSMGHQATGTVRKDHIDRVPLESDVALKKKERGTFDYRIDGKGNIVCRWNDNSVVTVASSGAGIHPLCLVSRYSQKLKKKIQVQQPNMIKVYNQFMGGVDRADENIDKYRASIRGKKWYSSPLLFCFELVLQNAWQLHKTYDEKPVDFLEFRRRVVCHYLETHGHPPEPGQKGRPQKRNIDSRYDGINHVIVKQGKQTRCAECHKNTTFRCEKCDVALHVKCSVEYHTE

Target ORF information:

RefSeq Version	NM_170753.3
Organism	Homo sapiens(human)
Definition	Homo sapiens piggyBac transposable element derived 3 (PGBD3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_170753.3

ORF Insert Sequence:

ATGCCTCGAA CACTAAGTTT ACATGAAATA ACTGACCTTT TAGAGACAGA TGACAGCATA 
GAAGCAAGTG CTATAGTGAT ACAACCACCT GAAAATGCTA CAGCACCTGT TTCTGATGAG 
GAATCAGGAG ATGAAGAAGG TGGAACAATA AATAATCTGC CAGGTTCTTT GTTGCACACA 
GCTGCGTATC TTATTCAAGA TGGCTCTGAT GCTGAGTCTG ACTCAGATGA TCCCTCATAC 
GCACCTAAAG ATGACTCTCC TGATGAAGTT CCATCTACGT TTACTGTGCA GCAACCTCCA 
CCATCAAGGA GGAGGAAAAT GACAAAAATT CTTTGCAAAT GGAAAAAAGC CGACCTAACT 
GTACAACCCG TAGCAGGTAG AGTTACAGCA CCACCAAACG ATTTCTTCAC CGTAATGAGA 
ACTCCCACAG AAATTCTTGA ACTTTTTCTT GATGACGAGG TCATTGAACT CATTGTCAAG 
TACTCCAACT TATATGCTTG CAGTAAAGGT GTACATCTTG GCTTGACTAG CTCTGAATTC 
AAATGTTTTC TGGGAATTAT TTTTCTGAGT GGTTATGTCT CAGTTCCTAG AAGGCGTATG 
TTTTGGGAAC AAAGAACAGA TGTGCATAAT GTACTGGTTA GTGCTGCCAT GAGACGTGAC 
CGGTTTGAAA CTATATTTTC TAATTTGCAT GTTGCTGACA ATGCAAATTT GGATCCAGTG 
GACAAATTTT CCAAATTGCG ACCTCTCATA AGCAAACTTA ATGAGAGATG CATGAAATTT 
GTTCCAAATG AAACATATTT CAGCTTTGAT GAATTCATGG TTCCTTATTT TGGTCGTCAC 
GGGTGCAAAC AATTTATTCG GGGAAAGCCC ATTCGGTTTG GCTATAAGTT TTGGTGTGGT 
GCCACCTGTC TGGGCTACAT TTGCTGGTTT CAGCCGTATC AGGGTAAAAA CCCAAATACT 
AAACATGAGG AATATGGTGT CGGTGCGTCA CTTGTCCTTC AGTTTAGTGA GGCACTTACA 
GAGGCACACC CTGGACAATA CCATTTTGTA TTCAATAACT TTTTCACCAG TATTGCACTT 
CTTGATAAGC TCAGTTCAAT GGGACATCAG GCAACAGGTA CAGTGAGAAA GGATCACATT 
GACAGAGTTC CACTGGAATC AGATGTAGCT TTAAAGAAAA AAGAAAGAGG CACATTTGAT 
TATCGAATTG ATGGCAAAGG CAATATTGTC TGCAGATGGA ATGATAACAG TGTTGTCACT 
GTTGCCTCAT CTGGTGCTGG TATCCATCCC CTGTGTCTTG TCAGTCGTTA CTCCCAGAAA 
CTGAAAAAGA AGATACAAGT TCAGCAGCCA AACATGATCA AAGTGTATAA CCAGTTCATG 
GGAGGCGTAG ACAGAGCTGA TGAAAACATT GATAAGTATC GGGCATCAAT CCGTGGAAAG 
AAATGGTATT CAAGCCCTCT TTTGTTCTGT TTCGAACTGG TCTTACAAAA TGCTTGGCAA 
TTGCATAAAA CATATGATGA GAAACCAGTG GATTTTCTGG AGTTTCGTCG ACGTGTGGTA 
TGCCATTATC TGGAGACCCA TGGTCATCCT CCAGAACCTG GCCAAAAAGG AAGACCTCAG 
AAGCGTAACA TTGACTCACG TTATGATGGC ATAAATCATG TGATAGTCAA ACAGGGAAAG 
CAAACGCGAT GCGCTGAATG TCATAAGAAC ACAACTTTTC GATGTGAAAA ATGTGATGTT 
GCCTTACATG TGAAGTGTTC CGTTGAATAT CACACTGAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

What role (if any) does the highly conserved CSB-PGBD3 fusion protein play in Cockayne syndrome?
Mechanisms of ageing and development134(5-6)225-33(2013 May-Jun)
Weiner AM,Gray LT

Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans.
PLoS genetics8(9)e1002972(2012 Sep)
Gray LT,Fong KK,Pavelitz T,Weiner AM

The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.
DNA repair11(5)488-501(2012 May)
Bailey AD,Gray LT,Pavelitz T,Newman JC,Horibata K,Tanaka K,Weiner AM

Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex.
Genes to cells : devoted to molecular & cellular mechanisms16(1)101-14(2011 Jan)
Horibata K,Saijo M,Bay MN,Lan L,Kuraoka I,Brooks PJ,Honma M,Nohmi T,Yasui A,Tanaka K

An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.
PLoS genetics4(3)e1000031(2008 Mar)
Newman JC,Bailey AD,Fan HY,Pavelitz T,Weiner AM

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PGBD3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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